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Готові списки джерел за темами / Triazole-3-thiol

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Добірка наукової літератури з теми "Triazole-3-thiol"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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Статті в журналах з теми "Triazole-3-thiol"

1

Zozulynets, D. М., A. G. Kaplaushenko, and A. S. Korzhova. "The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes." Journal of Organic and Pharmaceutical Chemistry 19, no. 1(73) (2021): 48–52. http://dx.doi.org/10.24959/ophcj.21.188137.

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Анотація:

Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reactionwith aldehydes.Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds s

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2

Safonov, A. A. "Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 98–101. http://dx.doi.org/10.32352/0367-3057.2.16.06.

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Анотація:

Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring. The purpose was to study acute toxicity of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols and identify possible patterns acute toxicity of the chemical structure of indicators derivatives. In the study of acute contact toxicity was used spreadsheet rapid method for Prozorovsky V. B. Analysis of the results of studies acute toxicity of 1,2,4-triazole derivatives showed that all substanc

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3

Ciesielski, Witold, and Anna Krenc. "Potentiometric Titration of Triazolethiols and Tetrazolethiols with Iodine in Alkaline Medium." Collection of Czechoslovak Chemical Communications 67, no. 8 (2002): 1193–99. http://dx.doi.org/10.1135/cccc20021193.

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Анотація:

The iodimetric determination of triazolethiols and tetrazolethiols in alkaline medium is presented. The volumetric titration with potentiometric end-point detection was applied. The range of determination, in which the error is lower than 1%, is 20-2 000 μmol for 1H-1,2,4-triazole-3-thiol (1), 25-1 000 μmol for 3-phenyl-1H-1,2,4-triazole-5-thiol (2), 25-500 μmol for 4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiol (3), 50-500 μmol for 3-amino-1H-1,2,4-triazole-5-thiol (4), 10-1 000 μmol for sodium (5-mercapto-1H-tetrazol-1-yl)acetate (5), 125-500 μmol for 1-phenyl-1H-tetrazole-5-thiol (6

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4

Khilkovets, A. V. "Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 152–56. http://dx.doi.org/10.14739/2409-2932.2021.2.232334.

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Анотація:

Heterocyclic compounds are one of the most important branches of modern organic chemistry and are widely used in medicine, pharmacy, agriculture, and in the production of new materials. One of these compounds is 1,2,4-triazole, which has attracted the attention of scientists around the world for many years. The aim of the work is to synthesize new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols and study their physical-chemical properties, conducting primary pharmacological screening. Materials and methods. Organic synthesis classical methods were used in the study, as well

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5

Karpenko, Yu V., and O. I. Panasenko. "Search for antibacterial activity in a number of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 173–78. http://dx.doi.org/10.14739/2409-2932.2021.2.234565.

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Анотація:

The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors of their structure, important for establishing patterns “structure – biological activity”. The aim of the work is a computer search for the antibacterial action of new hybrids of 1,2,4-triazole-3(2H)-thiol with a pyrimidine fragment in relation to 5 test cultures, to establish the dependence of “structure – action”. Materials and methods. For

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6

Safonov, A. A., and I. S. Nosulenko. "Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 162–66. http://dx.doi.org/10.14739/2409-2932.2021.2.230129.

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The process of studying free radicals began in the middle of the last century (the free radical theory of aging in 1956). Multiple studies have revealed the effect of free radicals on the cells of the body and the development of various diseases, such as diabetes, autoimmune diseases, diseases of the nervous system, and others. As a result, the term antioxidant has emerged, compounds that reduce and prevent the effects of free radicals. Most of the newly synthesized substances are studied for their antiradical properties. 1,2,4-Triazole derivatives are no exception, which has already proven th

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7

Singh, Ashok Kumar, and Khem Raj Kandel. "Synthesis of Triazole derivative: [4-(benzylideneamino)-5-phenyl -4H-1,2,4 – triazole-3-thiol]." Journal of Nepal Chemical Society 30 (December 19, 2013): 174–77. http://dx.doi.org/10.3126/jncs.v30i0.9391.

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Анотація:

The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol has been synthesized by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound which has been synthesized successfully was subjected to condensation with benzaldehyde to synthesize 4-(benzylideneamino)-5-phenyl -4H-1,2,4 – triazole-3-thiol (Schiff base). The compounds were confirmed by physical parameters (melting point), chromatographic methods (TLC) and spectroscopic methods (IR and NMR).DOI: http://dx.doi.org/10.3126/jncs.v30i0.9391Journal of Nepa

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8

Fedotov, S. O., A. S. Hotsulia, and Yu V. Karpenko. "Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol." Current issues in pharmacy and medicine: science and practice 16, no. 3 (2023): 205–12. http://dx.doi.org/10.14739/2409-2932.2023.3.288364.

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Анотація:

Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming normal physical and social activities. However, several existing analgesics may carry unwanted side effects, such as ulcers, blood clotting issues, drowsiness, and more. The development of new analgesics is focused on creating drugs that are both effective and associated with fewer adverse effects. Considering the continuous rise in the number of

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9

Kravchenko, T. V., O. I. Panasenko, and Ye G. Knysh. "Synthesis and physicochemical properties 4-((R))amino)-5-methyl-4H-1,2,4-triazole-3-thiols." Farmatsevtychnyi zhurnal, no. 6 (August 14, 2018): 55–59. http://dx.doi.org/10.32352/0367-3057.6.16.02.

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Анотація:

Purposeful synthesis of derivatives of 1,2,4-triazole is one of the most important branches of modern pharmaceutical science Modern pharmaceutical market of domestic medicines requires constant updates of existing range. It makes possible the synthesis of new compounds with a predicted biological activity. The main advantage of derivatives of 1,2,4-triazole is high efficiency and low toxic. That is promising factor for creation of new chemical compounds. Analysis of literary data of past few years has showed that there is not enough information about synthesis, physical, chem

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10

Pintea, Beniamin-Nicolae, Ion Burcă, Valentin Badea, and Francisc Peter. "Synthesis of a Novel 2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)acetaldehyde as a Bisulfite Adduct." Molbank 2023, no. 3 (2023): M1715. http://dx.doi.org/10.3390/m1715.

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Анотація:

The scope of the current work was to synthesize an S-alkylated 1,2,4-triazole-3-thiol derivative. Synthesis was carried out in two steps: in the first step, 4,5-diphenyl-4H-1,2,4-triazole-3-thiol was S-alkylated using a halogenated acetal and cesium carbonate. In the second step, several acetal deprotection procedures were tested, and the aldehyde obtained was isolated as a bisulfite adduct. The structures of the new compounds were characterized by FT-IR, 1D, and 2D NMR spectroscopic methods.

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Більше джерел

Тези доповідей конференцій з теми "Triazole-3-thiol"

1

Mykhailiuk, Yevhenii, and Ivan Bilai. "ANALGESIC ACTIVITY OF 4-R-5-PYRIDINE-1,2,4-TRIAZOLE-3-THIOL DERIVATIVES IN THE EXPERIMENT." In Scientific research, findings, and developments in technology in modern science. Publishing House “Baltija Publishing”, 2022. http://dx.doi.org/10.30525/978-9934-26-204-3-17.

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