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Relevant bibliographies by topics / Α-Defensin

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Academic literature on the topic 'Α-Defensin'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Α-Defensin"

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El-Mowafy, Mohammed, Abdelaziz Elgaml, Naglaa Abass, Amany A Mousa, and Mohamed N Amin. "The antimicrobial peptide alpha defensin correlates to type 2 diabetes via the advanced glycation end products pathway." African Health Sciences 22, no. 1 (2022): 303–11. http://dx.doi.org/10.4314/ahs.v22i1.37.

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Background: Diabetes is a serious health problem that results in high mortality rates worldwide. α-defensins are antimicrobial peptides of the innate immune system that contribute to inflammation. However, data on serum levels of α-defensin in patients suffering from type 2 diabetes are limited. Objectives: This study aimed to assess the possible changes in α-defensin serum levels in patients suffering from type 2 diabetes and to investigate its correlation with relevant biomarkers. Methodology: Analysis of serum α-defensin levels in 47 type 2 diabetics with diabetic neuropathy, 19

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Patil, Amar, Austin L. Hughes та Guolong Zhang. "Rapid evolution and diversification of mammalian α-defensins as revealed by comparative analysis of rodent and primate genes". Physiological Genomics 20, № 1 (2004): 1–11. http://dx.doi.org/10.1152/physiolgenomics.00150.2004.

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Mammalian α-defensins constitute a family of cysteine-rich, cationic antimicrobial peptides produced by phagocytes and intestinal Paneth cells, playing an important role in innate host defense. Following comprehensive computational searches, here we report the discovery of complete repertoires of the α-defensin gene family in the human, chimpanzee, rat, and mouse with new genes identified in each species. The human genome was found to encode a cluster of 10 distinct α-defensin genes and pseudogenes expanding 132 kb continuously on chromosome 8p23. Such α-defensin loci are also conserved in the

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Shi, Jishu, Shelly Aono, Wuyuan Lu, et al. "Regulation of IL-1beta secretion by defensins (100.11)." Journal of Immunology 178, no. 1_Supplement (2007): S199. http://dx.doi.org/10.4049/jimmunol.178.supp.100.11.

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Abstract Impaired expression of antimicrobial peptides α defensins and overproduction of proinflammatory cytokine IL-1β have been associated with inflammatory bowel disease (IBD). In this study, we examine the interactions between defensins and IL-1β and the role of defensin-deficiency in the pathogenesis of IBD. It was found that matrix metalloproteinase-7 deficient (MMP-7−/−) mice, which produce procryptdins but not mature cryptdins (α-defensins) in the intestine, were more susceptible to dextran sulfate sodium (DSS)-induced colitis. Furthermore, the baseline and DSS-induced IL-1β production

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Kling, Carolin, Anja Sommer, Yasser Almeida-Hernandez та ін. "Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action". International Journal of Molecular Sciences 24, № 13 (2023): 10557. http://dx.doi.org/10.3390/ijms241310557.

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Whooping cough is a severe childhood disease, caused by the bacterium Bordetella pertussis, which releases pertussis toxin (PT) as a major virulence factor. Previously, we identified the human antimicrobial peptides α-defensin-1 and -5 as inhibitors of PT and demonstrated their capacity to inhibit the activity of the PT enzyme subunit PTS1. Here, the underlying mechanism of toxin inhibition was investigated in more detail, which is essential for developing the therapeutic potential of these peptides. Flow cytometry and immunocytochemistry revealed that α-defensin-5 strongly reduced PT binding

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Madison, M. Nia, Yuliya Y. Kleshchenko, Pius N. Nde, Kaneatra J. Simmons, Maria F. Lima та Fernando Villalta. "Human Defensin α-1 Causes Trypanosoma cruzi Membrane Pore Formation and Induces DNA Fragmentation, Which Leads to Trypanosome Destruction". Infection and Immunity 75, № 10 (2007): 4780–91. http://dx.doi.org/10.1128/iai.00557-07.

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ABSTRACT Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that human defensin α-1 displays a trypanocidal role against Trypanosoma cruzi, the causative agent of Chagas' disease. The toxicity of human defensin α-1 against T. cruzi is mediated by membrane pore formation and the induction of nuclear and mitochondrial DNA fragmentation, leading to trypanosome destruction. Exposure of trypomastigote and amastigote forms of T. cruzi to defensin α-1 significantly reduced parasite viability in a peptide concentration-depende

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Shanahan, Michael T., Hiroki Tanabe та André J. Ouellette. "Strain-Specific Polymorphisms in Paneth Cell α-Defensins of C57BL/6 Mice and Evidence of Vestigial Myeloid α-Defensin Pseudogenes". Infection and Immunity 79, № 1 (2010): 459–73. http://dx.doi.org/10.1128/iai.00996-10.

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ABSTRACTPaneth cells at the base of small intestinal crypts secrete microbicidal α-defensins, termed cryptdins (Crps) in mice, as mediators of innate immunity. Proteomic studies show that five abundant Paneth cell α-defensins in C57BL/6 mice are strain specific in that they have not been identified in other inbred strains of mice. Two C57BL/6-specific peptides are coded for by theDefcr20and -21genes evident in the NIH C57BL/6 genome but absent from the Celera mixed-strain assembly, which excludes C57BL/6 data and differs from the NIH build with respect to the organization of the α-defensin gen

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Chang, Theresa Li-Yun, Fleur François, Arevik Mosoian та Mary E. Klotman. "CAF-Mediated Human Immunodeficiency Virus (HIV) Type 1 Transcriptional Inhibition Is Distinct from α-Defensin-1 HIV Inhibition". Journal of Virology 77, № 12 (2003): 6777–84. http://dx.doi.org/10.1128/jvi.77.12.6777-6784.2003.

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ABSTRACT CD8+ T lymphocytes can inhibit human immunodeficiency virus type 1 (HIV-1) replication by secreting a soluble factor(s) known as CD8+ T-lymphocyte antiviral factor (CAF). One site of CAF action is inhibition of HIV-1 RNA transcription, particularly at the step of long terminal repeat (LTR)-driven gene expression. The inhibitory effect of CAF on HIV-1 LTR activation is mediated through STAT1 activation. A recent study reports that α-defensins 1 to 3 account for CAF activity against HIV-1. Here, we address whether α-defensins, particularly α-defensin-1, contribute to CAF-mediated inhibi

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Johnson, Candice A., Girish Rachakonda, Yuliya Y. Kleshchenko та ін. "Cellular Response to Trypanosoma cruzi Infection Induces Secretion of Defensin α-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility, and Inhibits Infection". Infection and Immunity 81, № 11 (2013): 4139–48. http://dx.doi.org/10.1128/iai.01459-12.

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ABSTRACTHuman defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that colonic epithelial model HCT116 cells respond toTrypanosoma cruziinfection by secreting defensin α-1, which reduces infection. We also report the early effects of defensin α-1 on invasive trypomastigotes that involve damage of the flagellar structure to inhibit parasite motility and reduce cellular infection. Short exposure of defensin α-1 to trypomastigotes shows that defensin α-1 binds to the flagellum, resulting in flagellar membrane and axoneme alterat

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Tanabe, Hiroki, Jun Yuan, Melinda M. Zaragoza та ін. "Paneth Cell α-Defensins from Rhesus Macaque Small Intestine". Infection and Immunity 72, № 3 (2004): 1470–78. http://dx.doi.org/10.1128/iai.72.3.1470-1478.2004.

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ABSTRACT Antimicrobial peptides are secreted by small intestinal Paneth cells as components of innate immunity. To investigate the role of α-defensins in enteric host defenses in nonhuman primates, α-defensin cDNAs were isolated, α-defensin peptides were purified from rhesus macaque small bowel, and the bactericidal activities of the peptides were measured. Six rhesus enteric α-defensin (RED) cDNAs, RED-1 to RED-6, were identified in a jejunum cDNA library; the deduced RED peptides exhibited extensive diversity relative to the primary structures of rhesus myeloid α-defensins. RED-4 was purifie

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Shimizu, Yu, Kiminori Nakamura, Aki Yoshii та ін. "Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice". Life Science Alliance 3, № 6 (2020): e201900592. http://dx.doi.org/10.26508/lsa.201900592.

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Crohn’s disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of ER homeostasis in Paneth cells of the small intestine, and α-defensin misfolding have been reported in CD patients. Because α-defensins regulate the composition of the intestinal microbiota, their misfolding may cause dysbiosis. However, whether ER stress, α-defensin misfolding, and dysbiosis contribute to the pathophysiology of CD remains unknown. Here, we show that abnormal Paneth cells with markers of ER st

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Dissertations / Theses on the topic "Α-Defensin"

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Fiocco, Daniela. "α-DEFENSINS EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH HEPATITIS C VIRUS INFECTIONS". Doctoral thesis, La Sapienza, 2005. http://hdl.handle.net/11573/916796.

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Lockhart, Thomas. "A study of the oncolytic and cytolytic effects of human α-defensin 1 (HNP-1) and its truncated analogs". Thesis, Queen's University Belfast, 2009. https://pure.qub.ac.uk/portal/en/theses/a-study-of-the-oncolytic-and-cytolytic-effects-of-human---defensin-1-hnp1-and-its-truncated-analogs(eb84bad0-8a72-421f-b8ba-88b659fa27d2).html.

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Paslakis, Georgios. "Humane peritoneale Adipozyten synthetisieren antimikrobiell wirksame Peptide (α-Defensine)". Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-81978.

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Casanova, Güell Víctor. "L'Adenosina Desaminasa i les α-Defensines com a moduladors de respostes immunitàries front al VIH". Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/127152.

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L’ADA és un enzim del metabolisme purínic àmpliament distribuïda en els teixits humans. Durant molt de temps, s’ha considerat l’ADA com a enzim citosòlic, però recentment s’ha trobat també en la superfície de nombroses cèl•lules, fet que fa que sigui considerada, també, un ecto-enzim. L’ADA es pot unir a la superfície cel•lular mitjançant dos grups de proteïnes d’unió. Un grup és el format pels receptors d’adenosina. L’altre grup el constitueix el CD26, proteïna de membrana de tipus II, àmpliament distribuïda i amb activitat dipeptidil peptidasa IV (DPPIV). Recentment el grup ha demostrat

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Tomlinson, Gareth Hugh. "Anti-inflammatory mechanisms of the neutrophil-released antimicrobial peptide α-defensins". Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9552.

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Tissue homeostasis is necessary for optimal organ functioning. The onset of tissue trauma compromises the homeostatic environment resulting in widespread cell death with the likelihood of exposure to invading micro-organisms. Early stage elimination of microbes and immunomodulation is co-ordinated by leukocytes of the innate immune system of which neutrophils and macrophages play a pivotal role. Leukocyte-released pro-inflammatory factors are vital in the containment of infection but bring with it a degree of collateral tissue destruction. Thus cascading stages during inflammation must be tigh

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Lalli, Mina [Verfasser], та Bernhard [Akademischer Betreuer] Hauer. "Herausforderungen in der Herstellung, Reinigung und Charakterisierung der humanen α-Defensine 5 und 6 / Mina Lalli ; Betreuer: Bernhard Hauer". Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2015. http://d-nb.info/1123081034/34.

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NUNES, Maria Julliana Galvão. "Análise da expressão do TNF-α, β-Defensinas 2 e 3 e proteína p16 na mucosa anal de pacientes infectados pelo Papilomavírus humano". Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/25395.

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Submitted by Fernanda Rodrigues de Lima (fernanda.rlima@ufpe.br) on 2018-08-02T19:15:54Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE Maria Juliana Galvão Nunes.pdf: 2729731 bytes, checksum: 4b3c67fb4b7b283bbee0c2baa651bfef (MD5)<br>Rejected by Alice Araujo (alice.caraujo@ufpe.br), reason: on 2018-08-02T19:39:45Z (GMT)<br>Submitted by Fernanda Rodrigues de Lima (fernanda.rlima@ufpe.br) on 2018-08-02T19:45:59Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE Maria Juliana Galvão Nunes.pdf: 2

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Mayer-Scholl, Anne [Verfasser]. "Human neutrophils kill B. anthracis via an α-defensin [alpha-defensin] dependent mechanism / Anne Mayer-Scholl". 2006. http://d-nb.info/981792871/34.

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Tsai, Ping-Hsing, та 蔡秉興. "Identification of critical amino-acid residues in Vigna radiata plant defensin 1 involved in inhibiting Tenebrio molitor α-amylase". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/99284359689655527676.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>94<br>Vigna radiata defensin 1 (VrD1) is a small, basic and cysteine-rich peptide of 46 amino acids. In former study, VrD1 was reported to exhibit insecticidal activity, and three dimensional structure of VrD1 have been determined by nuclear magnetic resonance (NMR) spectroscopy. However, the insecticidal mechanism of VrD1 is still indistinct. Our preliminary data showed that VrD1, which was purified from mung bean, inhibited Tenebrio molitor α-amylase. To elucidate the α-amylase inhibition mechanism of VrD1, recombinant VrD1 was constructed, expressed and p

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Cheng, Kuo-Chang, та 鄭國璋. "Site-Directed Mutagenesis Studies of Potential Structural Element of Vigna radiata Plant Defensin 1 Involved in Inhibiting Insect α-Amylase". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/17595630855887881467.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>95<br>Vigna radiata plant defensin 1 (VrD1) is the first reported plant defensin exhibiting insecticidal activity against Callosobruchus chinensis (bruchid). Three dimensional structure of VrD1 has been determined by nuclear magnetic resonance spectroscopy in our laboratory. Nevertheless, the mechanism of insecticidal activity is unclear. According to our previous work, VrD1 has shown to inhibit Tenebrio molitor α-amylase (TMA) in vitro which may trigger insecticidal activity. Computational docking model of VrD1-TMA complex also implied that loop L3 of VrD1 is i

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Book chapters on the topic "Α-Defensin"

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Figueredo, Sharel, Jennifer R. Mastroianni, Kenneth P. Tai, and André J. Ouellette. "Expression and Purification of Recombinant α-Defensins and α-Defensin Precursors in Escherichia coli." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-594-1_4.

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Yu, Qitao, Jin-Long Yang, and James P. Tam. "Design of Cyclic α-Defensin Dimers as Channel Forming BuildingBlocks." In Peptides: The Wave of the Future. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_351.

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Mothes, H., M. Radeva, F. Jahns, and U. Settmacher. "Hohe Expression von enterischem α-Defensin (HD-6) in kolorektalen Adenomen und Karzinomen." In Chirurgisches Forum und DGAV Forum 2010. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12192-0_8.

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Zhang, H. "Dual Role of Neutrophil α-Defensins in Lung Inflammation." In Sepsis and Organ Dysfunction. Springer Milan, 2002. http://dx.doi.org/10.1007/978-88-470-2213-3_4.

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Mothes, Henning, R. Kaufmann, and U. Settmacher. "α-Defensine erhöhen invasives Potential von Kolon-Karzinomen in-vitro." In Chirurgisches Forum 2008. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-78833-1_25.

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"α-Defensin." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_100004.

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Higazi, Abd Al-Roof, Douglas B. Cines, and Khalil Bdeir. "α-Defensins." In Atherosclerosis and Autoimmunity. Elsevier, 2001. http://dx.doi.org/10.1016/b978-044450669-6/50009-8.

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Mishra, Abhijit, Kenneth P. Tai, Nathan W. Schmidt, André J. Ouellette, and Gerard C. L. Wong. "Small-Angle X-ray Scattering Studies of Peptide–Lipid Interactions Using the Mouse Paneth Cell α-Defensin Cryptdin-4." In Methods in Enzymology. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-381268-1.00016-1.

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Ouellette, André J., and Michael E. Selsted. "Paneth Cell α-Defensins." In Handbook of Biologically Active Peptides. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-385095-9.00177-9.

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OUELLETTE, ANDRE J. "Paneth Cell α-Defensins." In Handbook of Biologically Active Peptides. Elsevier, 2006. http://dx.doi.org/10.1016/b978-012369442-3/50144-6.

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Conference papers on the topic "Α-Defensin"

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Wang, D., X. Jing, W. Wang та Y. Su. "Wnt/β-Catenin Mediates α-Defensins-Induced Increases in Proliferation and Collagen Synthesis of Lung Fibroblasts." У American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3468.

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Petersen, P. P., Rosa L. Filipe та S. C. Bischoff. "Vitamin D-arme Ernährung beeinträchtigt die Darmbarrierefunktion durch Reduktion der α-Defensine im Ileum von C57BL6J Mäusen". У Nutrition 2023 | Dreiländertagung der Österreichischen Arbeitsgemeinschaft Klinische Ernährung (AKE), der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) und der Gesellschaft für Klinische Ernährung der Schweiz˵ (GESKES). Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1768191.

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Petersen, P. P., Rosa L. Filipe та S. C. Bischoff. "Vitamin D deficient diet deteriorates gut barrier function by reducing α-defensins in the ileum of C57BL6J mice". У Nutrition 2023 | Dreiländertagung der Österreichischen Arbeitsgemeinschaft Klinische Ernährung (AKE), der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) und der Gesellschaft für Klinische Ernährung der Schweiz˵ (GESKES). Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1768114.

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Ferreira, Marcos Antonio, Nathanael Nascimento Santos, Sthefany Dos Santos Brazil, Beatriz Gonçalves Guimarães, and Morgana Sousa Da Cunha. "USO DE PEPTÍDEOS ANTIMICROBIANOS COMO METODOLOGIA ALTERNATIVA NO COMBATE À COVID-19: UMA REVISÃO DE LITERATURA." In I Congresso Brasileiro de Doenças Infectocontagiosas On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2228.

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Introdução: a doença respiratória pandêmica COVID-19 que é causada pelos vírus SARS-COV-2 e suas variantes pertencentes à família Coronavírus matou, segundo dados científicos, mais de 4 mil pessoas até o início do segundo semestre de 2021. Isso tem levado cientistas e empresas farmacêuticas do mundo inteiro buscar metodologias para profilaxia, tratamento e cura dessa doença. Nesse panorama, pesquisas científicas mostram que peptídeos antimicrobianos (PAMs) e antivirais são excelentes candidatos ao desenvolvimento de estratégias no enfrentamento às doenças respiratórias causadas pelos coronavír

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