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Journal articles on the topic '18F–fluoro-deoxy-glucose-PET'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Medak, Adrianna, Julia Wojtowicz, Katarzyna Pietrasz, et al. "Użyteczność badania 18F-FDG PET/CT w diagnostyce guzów pierwotnych i przerzutów nowotworowych do mózgu." Letters in Oncology Science 17, no. 3 (2020): 1–7. http://dx.doi.org/10.21641/los.2020.17.3.183.

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Celem niniejszej pracy jest wykazanie, że mimo nieswoistego charakteru radiofarmaceutyku 2-deoxy-2-[18F]fluoro-D-glukozy (z ang. 2-deoxy-2-[18F]fluoro-D-glucose, 18F-FDG), badanie pozytonowej tomografii emisyjnej/tomografii komputerowej (z ang. positron emission tomography/computed tomography, PET/CT) z użyciem 18F-FDG pozwala wykryć guzy pierwotne i przerzuty nowotworowe do mózgu, co może znacząco wpłynąć na protokół terapeutyczny i jakość życia chorego onkologicznie.

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2

Kairemo, Kalevi, Elmer B. Santos, Homer A. Macapinlac, and Vivek Subbiah. "Early Response Assessment to Targeted Therapy Using 3′-deoxy-3′[(18)F]-Fluorothymidine (18F-FLT) PET/CT in Lung Cancer." Diagnostics 10, no. 1 (2020): 26. http://dx.doi.org/10.3390/diagnostics10010026.

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Although 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a sensitive nuclear medicine modality, specificity for characterizing lung cancer is limited. Tumor proliferation and early response to molecularly targeted therapy could be visualized using 3′-deoxy-3′[(18)F]-fluorothymidine (18F-FLT) PET/CT. The superiority of 18F-FLT PET/CT over 18F-FDG PET/CT in early therapeutic monitoring has been well described in patients after chemotherapy, radiotherapy, and/or chemo/radiotherapy. In thispilot study, we explorethe use of 18F-FLT PET/CT as an

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Munter-Young, Regina, Adolfo Fuentes-Alburo, Nicholas DiGregorio, Kurt Neeser, and Dmitry Gultyaev. "Clinical and economic outcomes of adding [18F]FES PET/CT in estrogen receptor status identification in metastatic and recurrent breast cancer in the US." PLOS ONE 19, no. 5 (2024): e0302486. http://dx.doi.org/10.1371/journal.pone.0302486.

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Background and objectives Correct identification of estrogen receptor (ER) status in breast cancer (BC) is crucial to optimize treatment; however, standard of care, involving biopsy and immunohistochemistry (IHC), and other diagnostic tools such as 2-deoxy-2-[18F]fluoro-D-glucose or 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), can yield inconclusive results. 16α-[18F]fluoro-17β-fluoroestradiol ([18F]FES) can be a powerful tool, providing high diagnostic accuracy of ER-positive disease. The aim of this study was to estimate the budget impact and cost-effectiveness of adding [18F]FES PET/CT to bi

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Huellner, M. W., M. Cousin, T. Linder, et al. "Melanoma of the middle ear: initial presentation, Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography imaging and follow up." Journal of Laryngology & Otology 125, no. 5 (2011): 536–39. http://dx.doi.org/10.1017/s0022215110002872.

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AbstractBackground:We present a rare case of primary mucosal melanoma of the middle ear imaged with 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT).Method:Clinical, radiological, intra-operative and histological findings are discussed.Results:An 88-year-old woman presented with intermittent otorrhoea of the left ear for several months. Otoscopy revealed a livid protrusion of the tympanic membrane. Melanoma was not suspected initially, but was established on transmembranous biopsy. Pre-operative 18F-fluoro-2-deoxy-d-glucose positron emission tomography

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5

Zhang-Yin, Jules, Antoine Girard, Etienne Marchal, et al. "PET Imaging in Bladder Cancer: An Update and Future Direction." Pharmaceuticals 16, no. 4 (2023): 606. http://dx.doi.org/10.3390/ph16040606.

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Molecular imaging with positron emission tomography is a powerful tool in bladder cancer management. In this review, we aim to address the current place of the PET imaging in bladder cancer care and offer perspectives on potential future radiopharmaceutical and technological advancements. A special focus is given to the following: the role of [18F] 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography in the clinical management of bladder cancer patients, especially for staging and follow-up; treatment guided by [18F]FDG PET/CT; the role of [18F]FDG PET/MRI, the other PET radiopharmaceu

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Honka, Miikka-Juhani, Eleni Rebelos, Simona Malaspina, and Pirjo Nuutila. "Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer." Metabolites 12, no. 4 (2022): 321. http://dx.doi.org/10.3390/metabo12040321.

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Evaluating in vivo the metabolic rates of the human liver has been a challenge due to its unique perfusion system. Positron emission tomography (PET) represents the current gold standard for assessing non-invasively tissue metabolic rates in vivo. Here, we review the existing literature on the assessment of hepatic metabolism, haemodynamics and cancer with PET. The tracer mainly used in metabolic studies has been [18F]2-fluoro-2-deoxy-D-glucose (18F-FDG). Its application not only enables the evaluation of hepatic glucose uptake in a variety of metabolic conditions and interventions, but based

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Pietrzak, Agata, Andrzej Marszałek, Tomasz Piotrowski, et al. "Primary and Metastatic Brain Tumours Assessed with the Brain and Torso [18F]FDG PET/CT Study Protocol—10 Years of Single-Institutional Experiences." Pharmaceuticals 14, no. 8 (2021): 722. http://dx.doi.org/10.3390/ph14080722.

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According to the international societies’ recommendations, the 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) technique should not be used as the method of choice in brain tumour diagnosis. Therefore, the brain region can be omitted during standard [18F]FDG PET/CT scanning. We performed comprehensive literature research and analysed results from 14,222 brain and torso [18F]FDG PET/CT studies collected in 2010–2020. We found 131 clinically silent primary and metastatic brain tumours and 24 benign lesions. We concluded that the brain and torso

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Adamcová, Vanda, Klára Kuglerová, Katarína Ondreičková, et al. "Visualization and quantification of 2-deoxy-2-fluoro[18F]-D-glucose in plant tissues by a commercial PET system." Nova Biotechnologica et chimica 19, no. 1 (2020): 98–108. http://dx.doi.org/10.36547/nbc.v19i1.582.

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Some works showed that commercial PET systems and 2-deoxy-2-fluoro[18F]-D-glucose (2-[18F]FDG) can be used in plant studies to analyze the transport and allocation of photoassimilates. The aim of this work was to evaluate the effect of characteristics of plant tissues, applied solution and the phenomenon of “escaping positrons” on the visualisation and quantification of the uptake and distribution

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Zhang, Xiang, Falguni Basuli, Zhen-Dan Shi, et al. "Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives." Molecules 28, no. 9 (2023): 3773. http://dx.doi.org/10.3390/molecules28093773.

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The use of radiolabeled glucose for PET imaging resulted in the most commonly used tracer in the clinic, 2-deoxy-2-[18F]fluoroglucose (FDG). More recently, other radiolabeled sugars have been reported for various applications, including imaging tumors and infections. Therefore, in this study, we developed a series of fluorine-18-labeled L-rhamnose derivatives as potential PET tracers of various fungal and bacterial strains. Acetyl-protected triflate precursors of rhamnose were prepared and radiolabeled with fluorine-18 followed by hydrolysis to produce L-deoxy [18F]fluororhamnose. The overall

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Sheikhbahaei, Sara, Rathan M. Subramaniam, and Lilja B. Solnes. "2-Deoxy-2-[18F] Fluoro-d-Glucose PET/Computed Tomography." PET Clinics 17, no. 2 (2022): 307–17. http://dx.doi.org/10.1016/j.cpet.2021.12.003.

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Kairemo, Kalevi, and Vivek Subbiah. "Molecular imaging of metastatic atrial angiosarcoma with positron emission tomography (PET) tracer 3′-deoxy-3′[(18)F]-fluorothymidine, [(18)F]-FLT imaging and early response evaluation." BMJ Case Reports 12, no. 5 (2019): e218979. http://dx.doi.org/10.1136/bcr-2016-218979.

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Primary cardiac angiosarcoma, the most common primary cardiac sarcoma has an incidence ranging from 0.001% to 0.028% in autopsy reports with around 200 cases reported in literature. Since a diagnosis of cardiac angiosarcoma portends a poor prognosis, it is vital to ascertain the precise extent of the lesions for follow-up. Imaging with positron emission tomography (PET) tracer 2-deoxy-2-[18F]-fluoro-D-glucose in cardiac angiosarcoma is challenging as myocardium takes up glucose and delineation of tumour becomes difficult. Cell proliferation rate in normal cardiac muscular tissue is low whereas

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12

Matsusaka, Yohji, Xinyu Chen, Paula Arias-Loza, et al. "In Vivo Functional Assessment of Sodium-Glucose Cotransporters (SGLTs) Using [18F]Me4FDG PET in Rats." Molecular Imaging 2022 (June 21, 2022): 1–7. http://dx.doi.org/10.1155/2022/4635171.

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Background. Mediating glucose absorption in the small intestine and renal clearance, sodium glucose cotransporters (SGLTs) have emerged as an attractive therapeutic target in diabetic patients. A substantial fraction of patients, however, only achieve inadequate glycemic control. Thus, we aimed to assess the potential of the SGLT-targeting PET radiotracer alpha-methyl-4-deoxy-4-[18F]fluoro-D-glucopyranoside ([18F]Me4FDG) as a noninvasive intestinal and renal biomarker of SGLT-mediated glucose transport. Methods. We investigated healthy rats using a dedicated small animal PET system. Dynamic im

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Hugon, Gaëlle, Sébastien Goutal, Ambre Dauba, et al. "[18F]2-Fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Monitoring of Enhanced Blood-Brain Barrier Permeability Induced by Focused Ultrasound." Pharmaceutics 13, no. 11 (2021): 1752. http://dx.doi.org/10.3390/pharmaceutics13111752.

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Focused ultrasound in combination with microbubbles (FUS) provides an effective means to locally enhance the delivery of therapeutics to the brain. Translational and quantitative imaging techniques are needed to noninvasively monitor and optimize the impact of FUS on blood-brain barrier (BBB) permeability in vivo. Positron-emission tomography (PET) imaging using [18F]2-fluoro-2-deoxy-sorbitol ([18F]FDS) was evaluated as a small-molecule (paracellular) marker of blood-brain barrier (BBB) integrity. [18F]FDS was straightforwardly produced from chemical reduction of commercial [18F]2-deoxy-2-fluo

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Shin, Young Shik, Jungwoo Kim, Dazy Johnson, et al. "Quantitative assessments of glycolysis from single cells." TECHNOLOGY 03, no. 04 (2015): 172–78. http://dx.doi.org/10.1142/s2339547815200058.

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The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose (18F-FDG). We report on an integrated microfluidics-chip/beta particle imaging system for in vitro 18F-FDG radioassays of glycolysis with single cell resolution. We investigated the kinetic responses of single glioblastoma cancer cells to targeted inhibitors of receptor tyrosine kinase signaling. Further, we find a weak positive correlation between cell size and rate of glycolysis.

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15

DeGrado, Timothy R., Mukesh K. Pandey, Anthony P. Belanger, Falguni Basuli, Aditya Bansal, and Shuyan Wang. "Noninvasive evaluation of fat-carbohydrate metabolic switching in heart and contracting skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 316, no. 2 (2019): E251—E259. http://dx.doi.org/10.1152/ajpendo.00323.2018.

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The ability of heart and skeletal muscle (SM) to switch between fat and carbohydrate oxidation is of high interest in the study of metabolic diseases and exercise physiology. Positron emission tomography (PET) imaging with the glucose analog 2-[18F]fluoro-2-deoxy-glucose (18F-FDG) provides a noninvasive means to quantitate glucose metabolic rates. However, evaluation of fatty acid oxidation (FAO) rates by PET has been limited by the lack of a suitable FAO probe. We have developed a metabolically trapped oleate analog, ( Z)-18-[18F]fluoro-4-thia-octadec-9-enoate (18F-FTO), and investigated the

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Ordonez, Alvaro A., Luz M. Wintaco, Filipa Mota, et al. "Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography." Science Translational Medicine 13, no. 589 (2021): eabe9805. http://dx.doi.org/10.1126/scitranslmed.abe9805.

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Enterobacterales represent the largest group of bacterial pathogens in humans and are responsible for severe, deep-seated infections, often resulting in sepsis or death. They are also a prominent cause of multidrug-resistant (MDR) infections, and some species are recognized as biothreat pathogens. Tools for noninvasive, whole-body analysis that can localize a pathogen with specificity are needed, but no such technology currently exists. We previously demonstrated that positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-d-sorbitol (18F-FDS) can selectively detect Enterobacterales infe

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Wienhard, K., G. Pawlik, B. Nebeling, et al. "Estimation of Local Cerebral Glucose Utilization by Positron Emission Tomography: Comparison of [18F]2-Fluoro-2-Deoxy-D-Glucose and [18F]2-Fluoro-2-Deoxy-D-Mannose in Patients with Focal Brain Lesions." Journal of Cerebral Blood Flow & Metabolism 11, no. 3 (1991): 485–91. http://dx.doi.org/10.1038/jcbfm.1991.92.

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A comparative PET study of [18F]2-fluoro-2-deoxy-D-glucose (FDG) and [18F]2-fluoro-2-deoxy-D-mannose (FDM) uptake was performed in 13 patients with focal brain lesions. Differences between FDG and FDM with respect to model rate constants, lumped constant, and estimated metabolic rate for glucose were determined on a regional basis. Across whole brain, the transport rate constant K*1 was almost unchanged, whereas k*2, describing the transport back from tissue to plasma, was 6% higher, and the phosphorylation rate constant k*3 was 9% lower for FDM compared to FDG. This implies a 20% lower lumped

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Donegani, Maria Isabella, Giulia Ferrarazzo, Stefano Marra, et al. "Positron Emission Tomography-Based Response to Target and Immunotherapies in Oncology." Medicina 56, no. 8 (2020): 373. http://dx.doi.org/10.3390/medicina56080373.

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2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is a promising tool to support the evaluation of response to either target therapies or immunotherapy with immune checkpoint inhibitors both in clinical trials and, in selected patients, at the single patient’s level. The present review aims to discuss available evidence related to the use of [18F]FDG PET (Positron Emission Tomography) to evaluate the response to target therapies and immune checkpoint inhibitors. Criteria proposed for the standardization of the definition of the PET-based response and complementary value with respect to morphological

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Feng, Han, Xiaobo Wang, Jian Chen, et al. "Nuclear Imaging of Glucose Metabolism: Beyond 18F-FDG." Contrast Media & Molecular Imaging 2019 (March 26, 2019): 1–12. http://dx.doi.org/10.1155/2019/7954854.

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Glucose homeostasis plays a key role in numerous fundamental aspects of life, and its dysregulation is associated with many important diseases such as cancer. The atypical glucose metabolic phenomenon, known as the Warburg effect, has been recognized as a hallmark of cancer and serves as a promising target for tumor specific imaging. At present, 2-deoxy-2-[18F]fluoro-glucose (18F-FDG)-based positron emission tomography/computed tomography (PET/CT) represented the state-of-the-art radionuclide imaging technique for this purpose. The powerful impact of 18F-FDG has prompted intensive research eff

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Rowe, Steven P., Paul G. Auwaerter, Sara Sheikhbahaei, Lilja B. Solnes, and William F. Wright. "Molecular Imaging of Infections: Emerging Techniques for Pathogen-Specific Diagnosis and Guided Therapy." Journal of Infectious Diseases 228, Supplement_4 (2023): S241—S248. http://dx.doi.org/10.1093/infdis/jiad092.

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Abstract Evaluation of patients that may be infected is challenging. Imaging to identify or localize a site of infection is often limited because of the nonspecific nature of the findings on conventional imaging modalities. Available imaging methods lack the ability to determine if antibiotics are reaching the site of infection and are not optimized to follow response to therapy. Positron emission tomography (PET) is a method by which radiolabeled molecules can be used to detect metabolic perturbations or levels of expression of specific targets. The most common PET agent is the glucose analog

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Pijl, Jordy P., Thomas C. Kwee, Riemer H. J. A. Slart, and Andor W. J. M. Glaudemans. "PET/CT Imaging for Personalized Management of Infectious Diseases." Journal of Personalized Medicine 11, no. 2 (2021): 133. http://dx.doi.org/10.3390/jpm11020133.

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Positron emission tomography combined with computed tomography (PET/CT) is a nuclear imaging technique which is increasingly being used in infectious diseases. Because infection foci often consume more glucose than surrounding tissue, most infections can be diagnosed with PET/CT using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), an analogue of glucose labeled with Fluorine-18. In this review, we discuss common infectious diseases in which FDG-PET/CT is currently applied including bloodstream infection of unknown origin, infective endocarditis, vascular graft infection, spondylodiscitis, and cyst inf

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Shin, Soo Hyun, Sang Hyun Park, Se Hun Kang, Seung Won Kim, Minsun Kim, and Daehong Kim. "Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism." Contrast Media & Molecular Imaging 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4896310.

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The presence of tumor-associated macrophages (TAMs) is significantly associated with poor prognosis of tumors. Currently, magnetic resonance imaging- (MRI-) based TAM imaging methods that use nanoparticles such as superparamagnetic iron oxide and perfluorocarbon nanoemulsions are available for quantitative monitoring of TAM burden in tumors. However, whether MRI-based measurements of TAMs can be used as prognostic markers has not been evaluated yet. In this study, we used positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) as a radioactive tracer and fluorine-19- (

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van Sluis, Joyce, Mar Bellido, Andor W. J. M. Glaudemans, and Riemer H. J. A. Slart. "Long Axial Field-of-View PET for Ultra-Low-Dose Imaging of Non-Hodgkin Lymphoma during Pregnancy." Diagnostics 13, no. 1 (2022): 28. http://dx.doi.org/10.3390/diagnostics13010028.

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Generally, positron emission tomography imaging is not often performed in the case of pregnant patients. The careful weighing of the risks of radiation exposure to the fetus and benefits for cancer staging and the swift onset of treatment for the mother complicates decision making in clinical practice. In oncology, the most commonly used PET radiotracer is 2-deoxy-2-[fluorine-18] fluoro-D-glucose (18F-FDG), a glucose analog which has established roles in the daily routines for, among other applications, initial diagnosis, staging, (radiation) therapy planning, and response monitoring. The intr

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Nikolova, Petya N., Valeria H. Hadzhiyska, Kiril B. Mladenov, et al. "Detection of Ureteral Stump Transitional Cell Carcinoma, Presenting as Bone Metastases from Unknown Primary by 18F-FDG PET/CT: A Case Report with Review of Literature." Indian Journal of Radiology and Imaging 31, no. 04 (2021): 1065–69. http://dx.doi.org/10.1055/s-0041-1741101.

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AbstractA case of occult carcinoma of the ureteral stump is reported. A 67-year-old man presented with pain syndrome due to multiple bone metastases from unknown primary origin detected by previous imaging studies as magnetic resonance imaging, whole body contrast-enhanced computed tomography (CT), and technetium-99m methyldiphosphonate bone scan. He had undergone a right nephrectomy for a benign disease previously. He was referred to our department for an 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to help localize possible primary tumor. O

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Burchardt, Ewa, Zaneta Warenczak-Florczak, Paulina Cegła, et al. "Differences between [18F]FLT and [18F]FDG Uptake in PET/CT Imaging in CC Depend on Vaginal Bacteriology." Diagnostics 12, no. 1 (2021): 70. http://dx.doi.org/10.3390/diagnostics12010070.

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This study aims to investigate if vaginal bacteriology obtained prior to treatment influences the 3′-deoxy-3 18F-fluorothymidine (FLT) [18F]FLT and 2-deoxy-2-[18F]fluoro-d-glucose (2-[18F]FDG) [18F]FDG parameters in positron emission tomography (PET/CT) in cervical cancer (CC) patients. Methods: Retrospective analysis was performed on 39 women with locally advanced histologically confirmed cervical cancer who underwent dual tracer PET/CT examinations. The [18F]FLT and [18F]FDG PET parameters in the primary tumor, including SUVmax, SUVmean, MTV, heterogeneity, before radiotherapy (RT) were anal

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Li, Wai Ip, Koon Kiu NG, and Boom Ting KUNG. "Incidental emergency vascular pathologies on [18F]FDG-PET/CT and their metabolic patterns: a case series." International Journal of Radiology & Radiation Therapy 11, no. 5 (2024): 111–14. http://dx.doi.org/10.15406/ijrrt.2024.11.00396.

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Purpose: We aim to review the image patterns of incidental vascular diseases on 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) Positron Emission Tomography/Computed Tomography (PET/CT). Material and methods: A retrospective review of [18F]FDG PET/CT examinations at the Nuclear Medicine Unit of Queen Elizabeth Hospital Hong Kong was performed, focusing on detections of emergency vascular pathologies, in correlation with the clinical history and other radiologic modalities and we analyzed the unique metabolic patterns observed in these cases. Results: Our analysis demonstrated that [18F]FDG PET/CT s

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Bjurberg, Maria, Elisabeth Kjellén, Tomas Ohlsson, Pär-Ola Bendahl, and Eva Brun. "Prediction of Patient Outcome With 2-Deoxy-2-[18F]fluoro-D-Glucose-Positron Emission Tomography Early During Radiotherapy for Locally Advanced Cervical Cancer." International Journal of Gynecologic Cancer 19, no. 9 (2009): 1600–1605. http://dx.doi.org/10.1111/igc.0b013e3181c00359.

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Introduction:It is difficult to assess the individual response of locally advanced cervical cancer to chemoradiation therapy during the course of treatment. We have investigated the predictive value of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) early during treatment in relation to progression-free survival.Methods:This prospective single-center clinical trial included women with locally advanced cervical cancer from 2004 to 2008. 2-Deoxy-2-[18F]fluoro-D-glucose-PET/computed tomography was performed at baseline, during the third week of treatment and, finally

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Park, Joo Yeon, Sun Mi Park, Tae Sup Lee, et al. "Radiopharmaceuticals for Skeletal Muscle PET Imaging." International Journal of Molecular Sciences 25, no. 9 (2024): 4860. http://dx.doi.org/10.3390/ijms25094860.

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The skeletal muscles account for approximately 40% of the body weight and are crucial in movement, nutrient absorption, and energy metabolism. Muscle loss and decline in function cause a decrease in the quality of life of patients and the elderly, leading to complications that require early diagnosis. Positron emission tomography/computed tomography (PET/CT) offers non-invasive, high-resolution visualization of tissues. It has emerged as a promising alternative to invasive diagnostic methods and is attracting attention as a tool for assessing muscle function and imaging muscle diseases. Effect

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Peltoniemi, Pauliina, Peter Lönnroth, Hanna Laine, et al. "Lumped constant for [18F]fluorodeoxyglucose in skeletal muscles of obese and nonobese humans." American Journal of Physiology-Endocrinology and Metabolism 279, no. 5 (2000): E1122—E1130. http://dx.doi.org/10.1152/ajpendo.2000.279.5.e1122.

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Quantitative 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography (PET) has been widely used to calculate glucose utilization in skeletal muscle. FDG-PET results depend partly on the lumped constant (LC), which accounts for the differences in the transport and phosphorylation between [18F]FDG and glucose. In this study, we estimated the LC for [18F]FDG directly in normal and in insulin-resistant obese subjects by combining FDG PET with the microdialysis technique. Eight obese [age 29.4 ± 1.0 yr, body mass index (BMI) 33.6 ± 1.0 kg/m2] and eight nonobese (age 25.0 ± 1.0 yr, B

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Gheysens, Olivier, François Jamar, Andor W. J. M. Glaudemans, Halil Yildiz, and Kornelis S. M. van der Geest. "Semi-Quantitative and Quantitative [18F]FDG-PET/CT Indices for Diagnosing Large Vessel Vasculitis: A Critical Review." Diagnostics 11, no. 12 (2021): 2355. http://dx.doi.org/10.3390/diagnostics11122355.

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To confirm the diagnosis of large vessel vasculitis (LVV) with high accuracy, one of the recommended imaging techniques is [18F]Fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography ([18F]FDG-PET/CT). Visual assessment of [18F]FDG uptake in the arterial wall compared to liver uptake is the mainstay for diagnosing LVV in routine clinical practice. To date, there is no consensus on the preferred semi-quantitative or quantitative parameter for diagnosing LVV. The aim of this review is to critically update the knowledge on the available evidence of semi-quantitative and qu

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Schmidt, K., G. Lucignani, R. M. Moresco, et al. "Errors Introduced by Tissue Heterogeneity in Estimation of Local Cerebral Glucose Utilization with Current Kinetic Models of the [18F]Fluorodeoxyglucose Method." Journal of Cerebral Blood Flow & Metabolism 12, no. 5 (1992): 823–34. http://dx.doi.org/10.1038/jcbfm.1992.114.

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The effects of tissue heterogeneity on the estimation of regional cerebral glucose utilization (rCMRglc) in normal humans with [18F]2-fluoro-2-deoxy-d-glucose ([18F]FDG) and positron emission tomography (PET) were compared with respect to the various kinetic models of the [18F]FDG method. The kinetic models were conventional homogeneous tissue models of the [18F]FDG method, with (4K Model) and without (3K Model) a rate constant to account for an apparent loss of [18F]2-fluoro-2-deoxy-d-glucose-6-phosphate ([18F]FDG-6-P), and a tissue heterogeneity model (TH Model). When either of the kinetic m

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Eicker, Sven O., Karl-Josef Langen, Norbert Galldiks, et al. "Clinical value of 2-deoxy-[18F]fluoro-d-glucose positron emission tomography in patients with cervical spondylotic myelopathy." Neurosurgical Focus 35, no. 1 (2013): E2. http://dx.doi.org/10.3171/2013.3.focus1379.

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Cervical spondylotic myelopathy (CSM) is one of the most common spinal cord disorders in the elderly. It is usually diagnosed by MRI, but in a significant number of patients the clinical course of CSM does not correlate with the extent of the spinal cord compression. Recent studies have suggested that a distinct metabolic pattern of the cervical cord, as assessed by PET with 2-deoxy-[18F]fluoro-d-glucose (18F-FDG) may predict a patient's clinical outcome after decompressive surgery for cervical spine stenosis. The authors provide an overview of the recent literature regarding the value of PET

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Simoncic, Urban, and Robert Jeraj. "Cumulative Input Function Method for Linear Compartmental Models and Spectral Analysis in PET." Journal of Cerebral Blood Flow & Metabolism 31, no. 2 (2010): 750–56. http://dx.doi.org/10.1038/jcbfm.2010.159.

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Compartmental modeling and spectral analysis are often used for tracer kinetic modeling in positron emission tomography (PET). The concentrations in kinetic equations are usually considered to be instantaneous, whereas PET data are inherently integrated over time, which leads to uncertainties in the results. A new formalism for kinetic analysis that uses cumulative tracer concentrations and avoids approximating the image-derived input function and PET measurements with midframe instantanous values was developed. We assessed the improvements of the new formalism over the midframe approximation

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Kuge, Yuji, Kazuo Minematsu, Yasuhiro Hasegawa, et al. "Positron Emission Tomography for Quantitative Determination of Glucose Metabolism in Normal and Ischemic Brains in Rats: An Insoluble Problem by the Harderian Glands." Journal of Cerebral Blood Flow & Metabolism 17, no. 1 (1997): 116–20. http://dx.doi.org/10.1097/00004647-199701000-00015.

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To examine the reliability of quantitative positron emission tomography studies in the rat (Rat–PET), we assessed the influence of radioactivity accumulated in the Harderian glands on PET CMRglc determination. We measured CMRglc by PET and ex vivo dissection methods by using 2-[18F]fluoro-2-deoxy-D-glucose in rats with and without focal brain ischemia. The CMRglc values obtained by PET, after correcting with recovery coefficients, were higher than those measured by the ex vivo method at rostral slices, and reduction of the CMRglc in the ischemic brain was not demonstrated by PET in the frontal

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Brittain, Jane Maestri, Michael Stormly Hansen, Jonathan Frederik Carlsen, et al. "Multimodality Imaging in Cranial Giant Cell Arteritis: First Experience with High-Resolution T1-Weighted 3D Black Blood without Contrast Enhancement Magnetic Resonance Imaging." Diagnostics 14, no. 1 (2023): 81. http://dx.doi.org/10.3390/diagnostics14010081.

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In order to support or refute the clinical suspicion of cranial giant cell arteritis (GCA), a supplemental imaging modality is often required. High-resolution black blood Magnetic Resonance Imaging (BB MRI) techniques with contrast enhancement can visualize artery wall inflammation in GCA. We compared findings on BB MRI without contrast enhancement with findings on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/low-dose computed tomography (2-[18F]FDG PET/CT) in ten patients suspected of having GCA and in five control subjects who had a 2-[18F]FDG PET/CT performed as a routine co

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Zhao, K., Y.-Z. Luo, S.-H. Zhou, et al. "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Findings in Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx: A Case Report and Literature Review." Journal of International Medical Research 40, no. 3 (2012): 1192–206. http://dx.doi.org/10.1177/147323001204000340.

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Laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma is rare, with only 25 cases reported in the literature. This report presents a case of laryngeal MALT lymphoma in a 35-year-old female with a 6-year history of progressively worsening hoarseness. MALT lymphoma was diagnosed based on biopsy and immunohistochemical analysis. The patient received two cycles of cyclo-phosphamide + epirubicin + vincristine + prednisone (CHOP) chemo therapy, which was ineffective. 18F-fluoro deoxy glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) showed 18F-FDG accumulation in the

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Rankin, S. "[18F]2-Fluoro-2-deoxy-D-glucose PET/CT in mediastinal masses." Cancer Imaging 10, no. 1A (2010): S156—S160. http://dx.doi.org/10.1102/1470-7330.2010.9026.

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Viswanathan, Chitra, Silvana Faria, Catherine Devine, et al. "[18F]-2-Fluoro-2-Deoxy-D-glucose–PET Assessment of Cervical Cancer." PET Clinics 13, no. 2 (2018): 165–77. http://dx.doi.org/10.1016/j.cpet.2017.11.004.

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Kumar, Ram, Nitin Gupta, Rajeev Ranjan, Ritu Verma, Ethel Belho, and Ishita Sen. "Discordant findings of different positron emission tomography/CT tracers in a case of glioblastoma." World Journal of Nuclear Medicine 20, no. 04 (2021): 401–4. http://dx.doi.org/10.4103/wjnm.wjnm_135_20.

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Abstract 18F-2-fluoro-2-deoxy-D-glucose ([18F]-FDG) positron emission tomography (PET) CT has proven useful in the evaluation of high-grade glioma and is also useful as a predictor of the degree of malignancy in newly diagnosed brain tumors. It is commonly accepted that high-grade gliomas are characterized by increased FDG uptake, whereas the low-grade glioma demonstrates reduced or absent FDG uptake. [18F]-FDOPA is an amino acid PET tracer which is a marker of the proliferative activity of brain tumors and demonstrates positive uptake in all grades of brain tumors; however, the degree of trac

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Colmenter, Luis Felipe, Sunil Daryanani, Sergio Zúñiga, and Javier Vilar. "Valor de la 18F-FDG-PET/CT en la estadificación inicial de pacientes con cáncer de tiroides de moderado/alto riesgo con subtipos histológicos agresivos." Investigación Clínica 65, no. 2 (2024): 253–63. http://dx.doi.org/10.54817/ic.v65n2a10.

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In recent years, positron emission tomography / computed to-mography (18F-FDG-PET / CT) or 2-(18F) -fluoro-2-deoxy-D-glucose has become an essential tool for the postoperative treatment of patients with differentiated thyroid cancer (CDT), and it is widely used in selected clinical situations. The most valuable role that 18F-FDG -PET / CT plays in clinical practice is that it can be used to obtain prognostic information in patients with increasing levels of thyroglobulin (Tg) and negative radioactive iodine (131I) body scan and ablation with 131I. The 18F-FDG -PET / CT may also have a potentia

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Herholz, Karl, Uwe Pietrzyk, Jürgen Voges, et al. "Correlation of glucose consumption and tumor cell density in astrocytomas." Journal of Neurosurgery 79, no. 6 (1993): 853–58. http://dx.doi.org/10.3171/jns.1993.79.6.0853.

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✓ To determine histological correlates of the variability of glucose consumption in astrocytomas, the authors performed positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (FDG) and matched the PET scans three-dimensionally with computerized tomography scans obtained in a stereotactic frame before biopsy. Ten patients with astrocytomas of World Health Organization Grade 2 or 3 were studied; patients with glioblastomas, oligodendrogliomas, or oligoastrocytomas were excluded from the study to avoid any confounding effects of different cell types and necroses. In samples of pur

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El Kiki, Nada Adel Awad, Fatma Salah El Deen Mohamed, Amal Amin Abu El Maati, and Nermeen Nasry Keriakos. "Relation between tumor SUVmax, TLR and TSR and breast carcinoma molecular subtypes in PET CT." International journal of health sciences 6, S1 (2022): 1763–72. http://dx.doi.org/10.53730/ijhs.v6ns1.4936.

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Breast cancer is known to be one of the most cancer affecting women around the globe and the second most common cancer in general. In third worlds countries, breast cancer is the most cause of cancer death. Early diagnosis and accurate follow-up of these patients affect the management. There are multiple prognostic factors most important one is the immunohistochemical molecular markers in the specimens including human epidermal growth factor, progesterone, and estrogen receptors (HER 2, PR, ER). In breast cancer, the HER2 positive molecular subtype is associated with bad prognosis and aggressi

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Huska, Brenda, Sarah Niccoli, Christopher P. Phenix та Simon J. Lees. "Leucine Potentiates Glucose-mediated 18F-FDG Uptake in Brown Adipose Tissue via β-Adrenergic Activation". Biomedicines 8, № 6 (2020): 159. http://dx.doi.org/10.3390/biomedicines8060159.

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Significant depots of brown adipose tissue (BAT) have been identified in many adult humans through positron emission tomography (PET), with the amount of BAT being inversely correlated with obesity. As dietary activation of BAT has implications for whole body glucose metabolism, leucine was used in the present study to determine its ability to promote BAT activation resulting in increased glucose uptake. In order to assess this, 2-deoxy-2-(fluorine-18)fluoro-d-glucose (18F-FDG) uptake was measured in C57BL/6 mice using microPET after treatment with leucine, glucose, or both in interscapular BA

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Mäki, Maija T., Merja T. Haaparanta, Matti S. Luotolahti, et al. "Fatty acid uptake is preserved in chronically dysfunctional but viable myocardium." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 5 (1997): H2473—H2480. http://dx.doi.org/10.1152/ajpheart.1997.273.5.h2473.

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Glucose uptake appears preserved or even enhanced in the chronically dysfunctional but viable myocardium. However, the use of other fuels such as free fatty acids (FFA) remains unknown. We studied FFA uptake in the chronically dysfunctional but viable myocardium in seven patients with an occluded major coronary artery and a corresponding chronic wall motion abnormality but no previous infarction. Myocardial FFA uptake kinetics in the fasting state were measured with positron emission tomography (PET) and 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA). The FFA uptake index was calc

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Kraus, Teresa, Marcus Hacker, Werner Langsteger, Shuren Li, and Raffaella Calabretta. "Diagnostic Value of 2-[18F]FDG PET/CT in a Patient with Atypical Subacute Thyroiditis: A Case Report." Life 12, no. 8 (2022): 1217. http://dx.doi.org/10.3390/life12081217.

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Background: Positron emission tomography/computed tomography (PET/CT) imaging with 2-deoxy-2-[18F]fluoro-d-glucose (2-[18F]FDG) is a sensitive diagnostic imaging modality in oncology and could be a useful diagnostic tool in patients with fever of unknown origin (FUO) or with inflammation of unknown origin (IUO). Case presentation: We report a case of a patient originally presenting with a clinical history of FUO and later with persistent high-sensitivity C-reactive protein (hsCRP) levels, even after antibiotic therapy. The patient underwent 2-[18F]FDG PET/CT to investigate and to localize a po

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de Paula Faria, Daniele, Larissa Estessi de Souza, Fabio Luis de Souza Duran, et al. "Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer’s Disease Rat Model: A Proof-of-Concept Study." International Journal of Molecular Sciences 23, no. 3 (2022): 1076. http://dx.doi.org/10.3390/ijms23031076.

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An early and persistent sign of Alzheimer’s disease (AD) is glucose hypometabolism, which can be evaluated by positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose ([18F]FDG). Cannabidiol has demonstrated neuroprotective and anti-inflammatory properties but has not been evaluated by PET imaging in an AD model. Intracerebroventricular (icv) injection of streptozotocin (STZ) is a validated model for hypometabolism observed in AD. This proof-of-concept study evaluated the effect of cannabidiol treatment in the brain glucose metabolism of an icv-STZ AD model by PET imaging. Wistar

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Honoré d’Este, Sabrina, Flemming Littrup Andersen, Julie Bjerglund Andersen, et al. "Potential Clinical Impact of LAFOV PET/CT: A Systematic Evaluation of Image Quality and Lesion Detection." Diagnostics 13, no. 21 (2023): 3295. http://dx.doi.org/10.3390/diagnostics13213295.

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We performed a systematic evaluation of the diagnostic performance of LAFOV PET/CT with increasing acquisition time. The first 100 oncologic adult patients referred for 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose PET/CT on the Siemens Biograph Vision Quadra were included. A standard imaging protocol of 10 min was used and scans were reconstructed at 30 s, 60 s, 90 s, 180 s, 300 s, and 600 s. Paired comparisons of quantitative image noise, qualitative image quality, lesion detection, and lesion classification were performed. Image noise (n = 50, 34 women) was acceptable according to the current st

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Sakulpisuti, Chaninart, Putthiporn Charoenphun, and Wichana Chamroonrat. "Positron Emission Tomography Radiopharmaceuticals in Differentiated Thyroid Cancer." Molecules 27, no. 15 (2022): 4936. http://dx.doi.org/10.3390/molecules27154936.

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Differentiated thyroid cancer (DTC), arising from thyroid follicular epithelial cells, is the most common type of thyroid cancer. Despite the well-known utilization of radioiodine treatment in DTC, i.e., iodine-131, radioiodine imaging in DTC is typically performed with iodine-123 and iodine-131, with the current hybrid scanner performing single photon emission tomography/computed tomography (SPECT/CT). Positron emission tomography/computed tomography (PET/CT) provides superior visualization and quantification of functions at the molecular level; thus, lesion assessment can be improved compare

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Kelley, David E., Katherine V. Williams, and Julie C. Price. "Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET." American Journal of Physiology-Endocrinology and Metabolism 277, no. 2 (1999): E361—E369. http://dx.doi.org/10.1152/ajpendo.1999.277.2.e361.

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The current study examined in vivo insulin regulation of glucose transport and phosphorylation in skeletal muscle of healthy, lean volunteers. Positron emission tomography (PET) imaging and compartmental modeling of the time course of skeletal muscle uptake and utilization after a bolus injection of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) was performed during metabolic steady-state conditions at four rates of euglycemic insulin infusion. Leg glucose uptake (LGU) was determined by arteriovenous limb balance assessments. The metabolism of [18F]FDG strongly correlated with skeletal muscle LGU

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Lin, Charles, Aravind Ravi Kumar, Jacqui Keller, et al. "18F-fluoro-L-thymidine Positron Emission Tomography for Mucosal Head and Neck Squamous Cell Carcinoma Treated with Definitive Chemoradiation: A Pilot Study of Nodal Assessment and Tracer Safety." ISRN Molecular Imaging 2013 (March 16, 2013): 1–7. http://dx.doi.org/10.1155/2013/710305.

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We aim to assess the utility and safety of 18F-fluoro-L-thymidine- positron emission tomography (FLT-PET), in reference to 18F-2-fluoro-2-deoxy-D-glucose (FDG-PET) in the assessment of nodal involvement for mucosal head and neck SCC (HNSCC). Methods. Ten patients with HNSCC receiving definitive chemoradiation (CRT) were enrolled. Baseline FLT-PET and FDG-PET were obtained. The total number of involved lymph nodes and ultimate nodal staging by the baseline FDG-PET and FLT-PET was compared. Receiver Operating Characteristics (ROC) analysis for the matched nodes was performed to identify an optim

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