Relevant bibliographies by topics / 2-a]pyrimidine

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '2-a]pyrimidine'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "2-a]pyrimidine"

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B., D. Mistry, R. Desai K., and I. Patel N. "Eco-friendly microwave enhanced synthesis of pyrido[2,3-d]pyrimidine as well as pyrido[1,2-a]pyrimidine derivatives and studies of their antimicrobial activity." J. Indian Chem. Soc. Vol. 88, Mar 2011 (2011): 465–72. https://doi.org/10.5281/zenodo.5766102.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India <em>E-mail</em>: bhavana_mistry11@yahoo.co.in <em>Manuscript received 28 January 2009, revised 17 June 2010, accepted 20 July 2010</em> 7-[4&#39; -(2&quot; ,5&quot; -Dihydroxyphenyl)phenyl]-2-methyl-5-(substitutedphenyi)3(H)pyrido[2,3-d]pyrimidin-4-one ( 4a-j) and 4-methyl-5-[ 4&#39; -(2&quot; ,5&quot; -dihydroxyphenyl)phenyl]-2-oxo-7 -(substitutedpheny 1)2(H) pyrido [ 1 ,2-a I pyrimidi n-8-c arbon i trite (Sa-j) have been synthesized by the reaction of 2-amino-6-[4&#39; -(2&quot; ,5&quot; -dihydroxyphenyl)phenyl
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Quesada, Antonio, Debbie Cannon, Jairo Quiroga, et al. "6-(2-Hydroxybenzoyl)-2-phenylpyrazolo[1,5-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 57, no. 2 (2001): o187—o188. http://dx.doi.org/10.1107/s1600536801001714.

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Ho, Yuh-Wen, and Maw Cherng Suen. "Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives." Journal of Chemistry 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/765243.

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A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio)pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine, 6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds, respectively. The structur
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Anaflous, Abderahmane, Nour-Eddine Benchat, Taibi Ben-Hadda, Brahim El Bali, and Michael Bolte. "3-Nitroso-2-phenylimidazo[1,2-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 60, no. 7 (2004): o1131—o1132. http://dx.doi.org/10.1107/s1600536804011699.

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A.K., Khalafallah, and A. Ahmed M. "A novel and efficient method for the synthesis of 6-amino-pyrimidine-2(1H)-thiones derivatives, pyrido [2,3-d] pyrimidine-2(1H)-thiones derivatives and their glycosides." Chemistry International 3, no. 4 (2017): 469–76. https://doi.org/10.5281/zenodo.1473402.

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Simple condensation reaction of 6-amino-pyrimidine-2(1H)-thiones with aromatic aldhydes afforded 6-(arylidene-amino)-pyrimidine-2-(1H)-thiones derivatives, that react with -nitrostyrene to give pyrido[2,3-d] pyrimidine-2-(1H)-thiones derivatives , the latter compounds served as key intermediate for the synthesis of a new class of pyrimidine-S-glycosides by the reaction with &alpha;-bromoglucose tetracetate. Deacetylation of glycoside have been achieved The structure of the compounds were established and confirmed on the basis of their elemental analysis and spectral data.
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Pinheiro, Alessandra C., Thaís C. M. Nogueira, Cristiane França da Costa, et al. "A study of antituberculosis activities and crystal structures of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine and (E)-N1-(arylidene)pyrimidine-2-carbohydrazide derivatives." Zeitschrift für Naturforschung B 75, no. 12 (2020): 1011–28. http://dx.doi.org/10.1515/znb-2020-0108.

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AbstractA study of the anti-tuberculosis activity against Mycobacterium tuberculosis ATTC 27294 and an X-ray structural determination of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine, 1, and (E)-N1-(arylidene)pyrimidine-2-carbohydazide, 2, derivatives are presented. The effect of the substituents in the aryl moiety on the antituberculosis (anti-TB) activities of 1 and 2 is compared with that of other heteroaryl hydrazonyl and acylhydrazonyl derivatives. The biological activities of 1 do not depend on the coordinating ability of the substituted aryl group: in 2, the most effective aryl group is 5-n
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Azam, Mohammed Afzal, Loganathan Dharanya, Charu Chandrakant Mehta, and Sumit Sachdeva. "Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system." Acta Pharmaceutica 63, no. 1 (2013): 19–30. http://dx.doi.org/10.2478/acph-2013-0001.

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In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2- yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1- (1,3-benzothiazol-2-yl)-4-(4-chlorophenyl)-3-methyl-1H-pyrazolo[ 3,4-d]pyrimidine (3d) and 1-(1,3-benzothiazol-2-yl)- 3-methyl-4-substituted phenyl-1H-pyrazolo[3,4-d]pyrimidines (3h-j) showed significant inhibitory activity against P. aeru
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Guan, Yue, Chunbo Wang, Daming Wang, et al. "Methylsulfone as a leaving group for synthesis of hyperbranched poly(arylene pyrimidine ether)s by nucleophilic aromatic substitution." RSC Advances 5, no. 17 (2015): 12821–23. http://dx.doi.org/10.1039/c5ra00634a.

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Using a novel leaving group, methylsulfone activated by pyrimidine, 4,6-dichloro-2-(methylsulfonyl)pyrimidine was used to synthesize two new hyperbranched poly(arylene pyrimidine ether)s with diphenol via a nucleophilic substitution polymerization.
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Cannon, Debbie, Antonio Quesada, Jairo Quiroga, et al. "6-(2-Hydroxybenzoyl)-2-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 57, no. 2 (2001): o182—o184. http://dx.doi.org/10.1107/s1600536801001696.

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Matković-Čalogović, Dubravka, Draginja Mrvoš-Sermek, Zora Popović та Željka Soldin. "A new complex of HgBr2and pyrimidine-2-thione: (pyrimidine-2-thionato-κS)(pyrimidinium-2-thionato-κS)mercury(II) tetrabromomercury(II)". Acta Crystallographica Section C Crystal Structure Communications 60, № 2 (2004): m44—m46. http://dx.doi.org/10.1107/s0108270103028014.

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Dissertations / Theses on the topic "2-a]pyrimidine"

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Griffon, Du Bellay Amaury. "Synthèse de ligands du récepteu de l'Urotensine II et des récepteurs de la Mélatonine. Composés à noyau pyrido[2,3-d]pyrimidine ou imidazo[1,2-a]pyridine." Phd thesis, Université d'Orléans, 2008. http://tel.archives-ouvertes.fr/tel-00418219.

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L'Urotensine II est un peptide vasoactif que l'on retrouve chez toutes les espèces étudiées. Elle présente une partie N-terminale linéaire variable selon l'espèce et une partie C-terminale hexocyclique constante et responsable de l'activité. Parmi les ligands développés, le Palosuran, un inhibiteur sélectif du récepteur de l'Urotensine II, présente un intérêt dans le traitement de l'insuffisance rénale du patient diabétique voire dans certaines pathologies ischémiques. Dans la première partie de ce travail de thèse, une série de composés à noyau pyrido[2,3-d]pyrimidine a été développée, tout d
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Bassoude, Ibtissam. "Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00789954.

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Nos travaux de thèse portent sur la mise au point de nouvelles méthodes de synthèse permettant l'accès de façon rapide et efficace à différents dérivés pyrazolo[1,5-a]pyrimidiniques diversement fonctionnalisés.La première partie de ce travail concerne l'étude et l'application de la condensation de la pyran-2-one avec les 5(3)-amino-3(5)-arylpyrazoles que ce soit par chauffage classique ou sous irradiation micro-onde. Par la suite, un nouveau procédé d'(hétéro)arylation pallado-catalysé direct régiosélectif a été mis à profit pour élaborer des pyrazolo[1,5-a]pyrimidines fonctionnalisées tant en
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Marzari, Mara Regina Bonini. "Síntese de pirazolo[1,5-a]pirimidinas e fluorfenilpirazóis trifluormetilados em ultrassom e síntese e aplicação de [2]rotaxanos." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/4287.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This work presents the synthesis of three series of trifluoromethylated heterocycles by using ultrasound irradiation, nomely pyrazolo[1,5-a]pyrimidines, 2,4- difluorophenylpyrazoles and pentafluorophenylpyrazoles. The reactions were performed between trifluoromethylated enones ([CF3C(O)CH=C(R)(OMe], where R = Me, Bu, i-Bu, Ph, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-IC6H4, thien-2-yl, naphthyl and biphenyl) with three different nucleophiles, nomely (3)(5)-amine-(5)(3)- methylpyrazole, 2,4-difluorophenylhydrazine hydrochloride an
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Book chapters on the topic "2-a]pyrimidine"

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Kleschick, William A., Mark J. Costales, B. Clifford Gerwick, et al. "1,2,4-Triazolo[1,5-a]pyrimidine-2-sulfonanilide Herbicides." In Synthesis and Chemistry of Agrochemicals III. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch002.

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Kleschick, William A., C. M. Carson, Mark J. Costales, et al. "1,2,4-Triazolo[1,5-a]pyrimidine-2-sulfonanilide Herbicides." In Synthesis and Chemistry of Agrochemicals III. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch003.

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Costales, Mark J., William A. Kleschick, and B. Clifford Gerwick. "N-(Substituted-2-fluorophenyl)- andN-(Substituted-2-trifluoromethylphenyl)-1,2,4-triazolo-[1,5-a]pyrimidine-2-sulfonanilides." In Synthesis and Chemistry of Agrochemicals III. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch004.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of trans-aquatrichlorobis-(5, 7-dimethyl[1, 2, 4]triazolo[1, 5-a]pyrimidine-N3)-ruthenium(III) monohydrate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_231.

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Fabianowska-Majewska, Krystyna, Tadeusz J. Wasiak, Krzysztof Warzocha, et al. "A New Mechanism of Toxicity of 2-Chlorodeoxyadenosine (2CdA)." In Purine and Pyrimidine Metabolism in Man VIII. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_28.

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Blakley, Raymond L., Min-Chi Huang, Richard A. Ashmun, and Rainer Koob. "Mechanism of Cytotoxicity of 2-Chloro and 2-Bromodeoxyadenosine for a Human Lymphoblastic Cell Line, CCRF-CEM." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_92.

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"Purine- and Pyrimidine-derived Natural Products." In Natural Product Biosynthesis. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/bk9781839165641-00316.

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Pyrimidine- and purine-based natural products could qualify as alkaloids (e.g. caffeine) but we take up these nucleoside natural products as a separate subclass, given the centrality of uracil/5-methyluracil, cytosine, adenine, and guanine in nucleic acid metabolism, and as starting points for varied nucleoside scaffolds and their roles as plant signaling molecules and natural antiviral and/or antibacterial agents. In the core tripartite structure of nucleobase, d-ribose sugar, and 5′-carbon substituent, one can find metabolites with altered nucleobase heterocycles (e.g. 7-deazguanines), alter
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Zanella, Alberto, and Paola Bianchi. "Erythrocyte enzymopathies." In Oxford Textbook of Medicine, edited by Chris Hatton and Deborah Hay. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0540.

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Numerous enzymes, including those of the hexose monophosphate and glycolytic pathways, are active in the red cell. They are required for the generation of ATP and the reductants NADH and NADPH. 2,3-Diphosphoglycerate, an intermediate of glucose metabolism, is a key regulator of the affinity of haemoglobin for oxygen, and accessory enzymes are also active for the synthesis of glutathione, disposal of oxygen free radicals, and for nucleotide metabolism. With the exception of heavy metal poisoning and rare cases of myelodysplasia, most red cell enzyme deficiency disorders are inherited. They may
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Lauria, Antonino, Chiara Patella, Patrizia Diana, et al. "New Tetracyclic Ring System of Biological Interest Indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidine through domino reactions of 2-azidoindole." In 19th International Congress on Heterocyclic Chemistry. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50216-1.

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Osawa, Syozo. "The structure of the ‘universal’ genetic code." In Evolution of the Genetic Code. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198547815.003.0002.

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Abstract The genetic code is written as a set of all 64 possible arrangements of the four RNA nucleotides-U, C, A, and G-in the form of a triplet (codon) (see Table 1.1). Each of 61 codons is assigned to a specific amino acid; the other three are stop codons that terminate the protein synthesis and do not correspond to any amino acid. As the number of amino acids used for protein synthesis is 20, the same amino acid can be coded for by more than one codon, i.e. the code is degenerate. For example, AAA and AAG are codons for Lys; GUG, GUC, GUA, and GUG are codons for Val. Further, six codons-CG
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Conference papers on the topic "2-a]pyrimidine"

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Shutalev, Anatoly, Ekaterina Kishko, and Natalie Sivova. "A New Approach to 5-Functionalized Pyrimidine-2-Thiones." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02012.

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Avdović, Edina, Dušica Simijonović, Žiko Milanović, Sandra Jovičić Milić, Sunčica Roca, and Dražen Vikić-Topić. "Chromeno-pyrimidine-type compounds (part II): in vitro evaluation of antioxidant potential." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.690a.

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The chromeno and pyrimidine classes compounds include a variety of hybrid molecules displaying diverse biological actions. Although they have been examined for many years, these compounds are still of interest due to their facile chemical transformations. The presence of chromeno and pyrimidine structural motifs in many drugs, prompted us to investigate the antioxidant features of compounds 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl) pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) and 8,9- ihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2). In this paper, we inv
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Shutalev, Anatoly. "A New Approach to the Synthesis of Hydrogenated Pyrimidine-2-imines." In The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01854.

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Prasad, N. L., M. S. Krishnamurthy, and Noor Shahina Begum. "Crystal structure studies of methyl 3-amino-2-cyano-5-(2-fluoro-phenyl)-7-methyl-5H-thiazolo [3,2-a]pyrimidine-6-carboxylate." In WORLD MULTIDISCIPLINARY CIVIL ENGINEERING-ARCHITECTURE-URBAN PLANNING SYMPOSIUM WMCAUS 2022. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0174743.

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Schnell, Barbara, and Thomas Kappe. "Rearrangement of Heterocycles via-2-oxoketenes: Synthesis and Rearrangement Reactions of Cross-Conjugated Mesomeric Pyridazino[2,3-a]pyrimidine." In The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01844.

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Nikalje, Anna Pratima, Julio Seijas Vázquez, Shailee Tiwari, and Zahid Zaheer. "Ultrasound-promoted One-Pot, Three Component Synthesis Of Novel 5-Amino-2-(4-Chlorophenyl)-7- Substituted Phenyl-8,8a-Dihydro-7H-[1,3,4]Thiadiazolo[3,2-A]Pyrimidine-6-Carbonitrile Derivatives." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a048.

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Gangjee, Aleem, Sai Zhao, Lalit Kumar, et al. "Abstract 5492: Study the variation of the glutamate moiety of AG94, a targeted, potent GARFTase inhibitor, as antitumor agents with the 2-amino-6-substituted pyrrolo[2,3-d]pyrimidine scaffold." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5492.

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Engasheva, E. S., and D. D. Novikov. "THE EFFICACY OF THE COMBINATION DRUG AGAINST APHANIPTEROSIS IN CATS." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2025. https://doi.org/10.31016/978-5-6053355-1-1.2025.26.100-104.

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The insecticidal efficacy and safety of a new combination drug in tablet formulation based on derivatives of spinosyns, pyrimidines and pyrazinoisoquinoline against aphanipterosis in cats was studied. The study was carried out on 16 animals with spontaneous infestation with fleas Ctenocephalides spp. which were divided into two groups: experimental and control groups of 8 animals each. The animals of the experimental group were given the drug individually, once, orally, on the root of the tongue immediately after feeding in the minimum dose per 1 kg of animal weight (by active ingredients): 50
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Luo, Yunting, Mathew Martin, Robert Kendig, et al. "Abstract 3252: Potent Aurora kinase inhibitors based on a pyrimidine scaffold: Synthesis, SAR and X-ray crystallography studies." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3252.

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Desmoulin, Sita Kugel, Lei Wang, Larry Tait, et al. "Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2528.

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