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Journal articles on the topic '2-a]pyrimidine'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

B., D. Mistry, R. Desai K., and I. Patel N. "Eco-friendly microwave enhanced synthesis of pyrido[2,3-d]pyrimidine as well as pyrido[1,2-a]pyrimidine derivatives and studies of their antimicrobial activity." J. Indian Chem. Soc. Vol. 88, Mar 2011 (2011): 465–72. https://doi.org/10.5281/zenodo.5766102.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India <em>E-mail</em>: bhavana_mistry11@yahoo.co.in <em>Manuscript received 28 January 2009, revised 17 June 2010, accepted 20 July 2010</em> 7-[4' -(2" ,5" -Dihydroxyphenyl)phenyl]-2-methyl-5-(substitutedphenyi)3(H)pyrido[2,3-d]pyrimidin-4-one ( 4a-j) and 4-methyl-5-[ 4' -(2" ,5" -dihydroxyphenyl)phenyl]-2-oxo-7 -(substitutedpheny 1)2(H) pyrido [ 1 ,2-a I pyrimidi n-8-c arbon i trite (Sa-j) have been synthesized by the reaction of 2-amino-6-[4' -(2" ,5" -dihydroxyphenyl)phenyl

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2

Quesada, Antonio, Debbie Cannon, Jairo Quiroga, et al. "6-(2-Hydroxybenzoyl)-2-phenylpyrazolo[1,5-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 57, no. 2 (2001): o187—o188. http://dx.doi.org/10.1107/s1600536801001714.

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3

Ho, Yuh-Wen, and Maw Cherng Suen. "Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives." Journal of Chemistry 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/765243.

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A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio)pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine, 6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds, respectively. The structur

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4

Anaflous, Abderahmane, Nour-Eddine Benchat, Taibi Ben-Hadda, Brahim El Bali, and Michael Bolte. "3-Nitroso-2-phenylimidazo[1,2-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 60, no. 7 (2004): o1131—o1132. http://dx.doi.org/10.1107/s1600536804011699.

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5

A.K., Khalafallah, and A. Ahmed M. "A novel and efficient method for the synthesis of 6-amino-pyrimidine-2(1H)-thiones derivatives, pyrido [2,3-d] pyrimidine-2(1H)-thiones derivatives and their glycosides." Chemistry International 3, no. 4 (2017): 469–76. https://doi.org/10.5281/zenodo.1473402.

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Simple condensation reaction of 6-amino-pyrimidine-2(1H)-thiones with aromatic aldhydes afforded 6-(arylidene-amino)-pyrimidine-2-(1H)-thiones derivatives, that react with -nitrostyrene to give pyrido[2,3-d] pyrimidine-2-(1H)-thiones derivatives , the latter compounds served as key intermediate for the synthesis of a new class of pyrimidine-S-glycosides by the reaction with α-bromoglucose tetracetate. Deacetylation of glycoside have been achieved The structure of the compounds were established and confirmed on the basis of their elemental analysis and spectral data.

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6

Pinheiro, Alessandra C., Thaís C. M. Nogueira, Cristiane França da Costa, et al. "A study of antituberculosis activities and crystal structures of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine and (E)-N1-(arylidene)pyrimidine-2-carbohydrazide derivatives." Zeitschrift für Naturforschung B 75, no. 12 (2020): 1011–28. http://dx.doi.org/10.1515/znb-2020-0108.

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AbstractA study of the anti-tuberculosis activity against Mycobacterium tuberculosis ATTC 27294 and an X-ray structural determination of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine, 1, and (E)-N1-(arylidene)pyrimidine-2-carbohydazide, 2, derivatives are presented. The effect of the substituents in the aryl moiety on the antituberculosis (anti-TB) activities of 1 and 2 is compared with that of other heteroaryl hydrazonyl and acylhydrazonyl derivatives. The biological activities of 1 do not depend on the coordinating ability of the substituted aryl group: in 2, the most effective aryl group is 5-n

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7

Azam, Mohammed Afzal, Loganathan Dharanya, Charu Chandrakant Mehta, and Sumit Sachdeva. "Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system." Acta Pharmaceutica 63, no. 1 (2013): 19–30. http://dx.doi.org/10.2478/acph-2013-0001.

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In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2- yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1- (1,3-benzothiazol-2-yl)-4-(4-chlorophenyl)-3-methyl-1H-pyrazolo[ 3,4-d]pyrimidine (3d) and 1-(1,3-benzothiazol-2-yl)- 3-methyl-4-substituted phenyl-1H-pyrazolo[3,4-d]pyrimidines (3h-j) showed significant inhibitory activity against P. aeru

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8

Guan, Yue, Chunbo Wang, Daming Wang, et al. "Methylsulfone as a leaving group for synthesis of hyperbranched poly(arylene pyrimidine ether)s by nucleophilic aromatic substitution." RSC Advances 5, no. 17 (2015): 12821–23. http://dx.doi.org/10.1039/c5ra00634a.

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Using a novel leaving group, methylsulfone activated by pyrimidine, 4,6-dichloro-2-(methylsulfonyl)pyrimidine was used to synthesize two new hyperbranched poly(arylene pyrimidine ether)s with diphenol via a nucleophilic substitution polymerization.

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9

Cannon, Debbie, Antonio Quesada, Jairo Quiroga, et al. "6-(2-Hydroxybenzoyl)-2-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 57, no. 2 (2001): o182—o184. http://dx.doi.org/10.1107/s1600536801001696.

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10

Matković-Čalogović, Dubravka, Draginja Mrvoš-Sermek, Zora Popović та Željka Soldin. "A new complex of HgBr2and pyrimidine-2-thione: (pyrimidine-2-thionato-κS)(pyrimidinium-2-thionato-κS)mercury(II) tetrabromomercury(II)". Acta Crystallographica Section C Crystal Structure Communications 60, № 2 (2004): m44—m46. http://dx.doi.org/10.1107/s0108270103028014.

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11

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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12

Askar, Firyal w., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.2010.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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13

Shanmugasundaram, Muthian, Annamalai Senthilvelan, and Anilkumar R. Kore. "C-5 Substituted Pyrimidine Nucleotides/Nucleosides: Recent Progress in Synthesis, Functionalization, and Applications." Current Organic Chemistry 23, no. 13 (2019): 1439–68. http://dx.doi.org/10.2174/1385272823666190809124310.

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The chemistry of C5 substituted pyrimidine nucleotide serves as a versatile molecular biology probe for the incorporation of DNA/RNA that has been involved in various molecular biology applications such as gene expression, chromosome, and mRNA fluorescence in situ hybridization (FISH) experiment, mutation detection on arrays and microarrays, in situ RT-PCR, and PCR. In addition to C5 substituted pyrimidine nucleotide, C5 substituted pyrimidine nucleoside displays a broad spectrum of biological applications such as antibacterial, antiviral and anticancer activities. This review focusses on the

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14

Ren, Demin, Ye Tang, Xianyong Yu, Yulin Huang, and Xiaofang Li. "Synthesis of spiro[cyclopent-2/3-ene-1,2′-[1,3]thiazolo[3,2-a] pyrimidine] derivatives via 1,3-dipolar cycloaddition reaction of ethyl buta-2,3-dienoate." Journal of Chemical Research 42, no. 12 (2018): 631–35. http://dx.doi.org/10.3184/174751918x15426290490753.

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The 1,3-dipolar cycloaddition reaction of ethyl (2Z)-5-aryl-2-(2-methoxy-2-oxoethylidene)-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a] pyrimidine-6-carboxylate and ethyl buta-2,3-dienoate catalysed by triphenylphosphine afforded novel spiro[cyclopent-2-ene-1,2′-[1,3] thiazolo[3,2-a]pyrimidine] and spiro[cyclopent-3-ene-1,2′-[1,3]thiazolo[3,2-a]pyrimidine] derivatives in moderate yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS together with X-ray crystallographic analysis.

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15

Prager, Rolf H., Jason A. Smith, and Edward R. T. Tiekink. "Ethyl 3-methylimidazo[1,2-a]pyrimidine-2-carboxylate." Acta Crystallographica Section E Structure Reports Online 57, no. 5 (2001): o451—o453. http://dx.doi.org/10.1107/s1600536801006316.

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16

Severina, Hanna I., Olga O. Skupa, Natalya I. Voloshchuk, Marharyta M. Suleiman, and Victoriya A. Georgiyants. "Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization." Pharmacia 66, no. (3) (2019): 141–46. https://doi.org/10.3897/pharmacia.66.e38137.

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The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K<sub>2</sub>CO<sub>3</sub> a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylat

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17

Severina, Hanna, Olga O. Skupa, Natalya I. Voloshchuk, Marharyta M. Suleiman, and Victoriya A. Georgiyants. "Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization." Pharmacia 66, no. 3 (2019): 141–46. http://dx.doi.org/10.3897/pharmacia.66.e38137.

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The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3 a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylated derivatives – 2-(2-

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18

Yokota, Kenichirou, Masayori Hagimori, Naoko Mizuyama, et al. "Synthesis, solid-state fluorescence properties, and computational analysis of novel 2-aminobenzo[4,5]thieno[3,2-d]pyrimidine 5,5-dioxides." Beilstein Journal of Organic Chemistry 8 (February 16, 2012): 266–74. http://dx.doi.org/10.3762/bjoc.8.28.

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New fluorescent compounds, benzo[4,5]thieno[3,2-d]pyrimidine 5,5-dioxides (3a–g), 2-amino-4-methylsulfanylbenzo[4,5]thieno[3,2-d]pyrimidine (6), and 2-amino-4-methylsulfanyl-7-methoxybenzo[4,5]furo[3,2-d]pyrimidine (7), were synthesized in good yields from heterocyclic ketene dithioacetals (1a–c) and guanidine carbonate (2a) or (S)-methylisothiourea sulfate (2b) in pyridine under reflux. Among the fused pyrimidine derivatives, compound 3c, which has an amino group at the 2-position and a benzylamino group at the 4-position of the pyrimidine ring, showed the strongest solid-state fluorescence.

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19

Abdelhamid, Abdou O., and Sobhi M. Gomha. "Synthesis of New Pyrazolo[1,5-a]pyrimidine, Triazolo[4,3-a]pyrimidine Derivatives, and Thieno[2,3-b]pyridine Derivatives from Sodium 3-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-olate." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/327095.

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Condensation of sodium 3-oxo-3-(1-phenyl-1H-pyrazol-4-yl)prop-1-en-1-olate (2) with several heterocyclic amines, cyanoacetamide, cyanothioacetamide, and 2-cyanoacetohydrazide gives pyrazolo[1,5-a]pyrimidines (5a–d), pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine (9), benzo[4,5]imidazo[1,2-a]pyrimidine (10), [1,2,4]triazolo[1,5-a]pyrimidine (11), and pyridine derivatives (12–14). Also, thieno[2,3-b]pyridines (15–18) were synthesized via pyridinethione (13) withα-halo ketones andα-halo ester. Structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, alternat

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20

Yasui, Masanori, Yoshimitsu Ishikawa, Naoya Akiyama, Takayuki Ishida, Takashi Nogami, and Fujiko Iwasaki. "Dipyrimidine–copper(II) dinitrate complexes showing magnetic interactions." Acta Crystallographica Section B Structural Science 57, no. 3 (2001): 288–95. http://dx.doi.org/10.1107/s0108768101002737.

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Crystals of CuII(NO3)2(pm)3 (1), and two crystalline forms of CuII(NO3)2(H2O)2(pm)2, (2) and (3), showed ferromagnetic, antiferromagnetic and paramagnetic interactions at extremely low temperatures, respectively. Crystal structure analyses revealed that the complexes were catena-dinitrato[μ-pyrimidine-κN 1:κN 3]-(pyrimidine-N 1)copper(II), [Cu(NO3)2(pm)2] n , catena-diaquadinitrato[μ-pyrimidine-κN 1:κN 3]copper(II), [Cu(NO3)2(H2O)2(pm)] n , and diaquadinitratodipyrimidinecopper(II), Cu(NO3)2(H2O)2(pm)2 for (1), (2) and (3), respectively. In (1) the Cu atom is coordinated by the two nitrates an

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21

Ishigeev, R. S., S. V. Amosova, and V. A. Potapov. "Reactions of Pyrimidine-2-sulfenyl Chloride with Alkylvinyl and Allyl Ethers." Žurnal obŝej himii 94, no. 7 (2024): 836–42. https://doi.org/10.31857/s0044460x24070058.

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The regioselective synthesis of novel thiazolo[3,2-a]pyrimidine derivatives in 52–92% yields was developed based on the reaction of pyrimidine-2-sulfenyl chloride with unsaturated ethers. The reaction with allylic and vinylic ethers proceed regioselectively, but with the opposite regiochemistry. The reaction with allylic ethers lead to 2-substituted thiazolo[3,2-a]pyrimidine derivatives whereas 3-organyloxy derivatives are formed in the reaction with vinylic ethers.

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22

Stasevych, Maryna, Svitlana Sabat, Rostyslav Musyanovych, and Volodymyr Novikov. "Synthesis of condensed S-, N- containing heterocyclic systems on the base of 2-amino-4,9-dioxo-4,9-dihydronaphto[2,3-b]thiophene-3-ethylcarboxilate." Chemistry & Chemical Technology 2, no. 3 (2008): 157–62. http://dx.doi.org/10.23939/chcht02.03.157.

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Synthesis of a new 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones, 2-arylnaphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-4,5,10(3Н)-triones, 3-phenyl naphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-2,4,5,10(1Н, 3Н)-tetraone and 2-thioxo-2,3-dyhydronaphth[2’,3’,4,5]thieno[2,3-d]pyrimidine-4,5,10(1Н)-trione was carried out. The mechanism of 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones formation was suggested.

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23

Vicentes, Daniel E., Ricaurte Rodríguez, Patricia Ochoa, Justo Cobo, and Christopher Glidewell. "A concise and efficient synthesis of amino-substituted (1H-benzo[d]imidazol-1-yl)pyrimidine hybrids: synthetic sequence and the molecular and supramolecular structures of six examples." Acta Crystallographica Section C Structural Chemistry 75, no. 10 (2019): 1405–16. http://dx.doi.org/10.1107/s2053229619012087.

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A concise and efficient synthesis of a series of amino-substituted benzimidazole–pyrimidine hybrids has been developed, starting from the readily available N 4-(2-aminophenyl)-6-methoxy-5-nitrosopyrimidine-2,4-diamine. In each of N 5-benzyl-6-methoxy-4-(2-phenyl-1H-benzo[d]imidazol-1-yl)pyrimidine-2,5-diamine, C25H22N6O, (I), 6-methoxy-N 5-(4-methoxybenzyl)-4-[2-(4-methoxyphenyl)-1H-benzo[d]imidazol-1-yl]pyrimidine-2,5-diamine, C27H26N6O3, (III), 6-methoxy-N 5-(4-nitrobenzyl)-4-[2-(4-nitrophenyl)-1H-benzo[d]imidazol-1-yl]pyrimidine-2,5-diamine, C25H20N8O5, (IV), the molecules are linked into t

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24

Verma, Mohan, and Prabhakar Kumar Verma. "Synthesis, characterization, antimicrobial and anticancer evaluation of (E)-N'-benzylidene-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide derivatives." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4498–502. http://dx.doi.org/10.55522/jmpas.v11i2.2190.

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The synthesis of a novel family of pyrimidine derivatives has been completed. Infrared–infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectrum data were used to describe these pyrimidine derivatives. All the compounds were evaluated for their in vitro antimicrobial activity against Gram negative strain (Escherichia coli) and Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain (Candida albicans and Aspergillus niger) and anticancer potential against Human breast cancer cell line (MCF-7). Results of antimicrobial and anticancer study revealed that

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V. VOSTRIKOVA, Tatiana, Vladislav N. KALAEV, Andrey Yu POTAPOV, Dmitry Y. VANDYSHEV, and Khidmet S. SHIKHALIEV. "USING SYNTHESISED ORGANIC COMPOUNDS AS ENVIRONMENTALLY FRIENDLY RETARDANTS FOR ORNAMENTAL PLANTS." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 28, no. 28 (2020): 40–44. http://dx.doi.org/10.48141/sbjchem.v28.n28.2020.06_vostrikova_pgs_40_44.pdf.

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The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the gre

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Vostrikova, Tatiana, Vladislav Kalaev, Andrey Potapov, Dmitry Vandyshev, and Khidmet Shikhaliev. "Using Synthesised Organic Compounds as Environmentally Friendly Retardants for Ornamental Plants." Southern Brazilian Journal of Chemistry 28, no. 28 (2020): 40–44. http://dx.doi.org/10.37633/sbjc.28(28)2020.40-44.

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The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2- piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the gr

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27

Schwade, Vania Denise, Ernesto Schulz Lang та Luana Floriano. "A three-dimensional metal–organic polymer: poly[bis(μ2-pyrimidine-2-thiolato-κ4N1,S:S,N3)lead(II)]". Acta Crystallographica Section C Structural Chemistry 71, № 7 (2015): 517–20. http://dx.doi.org/10.1107/s2053229615010359.

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The title compound, [Pb(C4H3N2S)2]n, was prepared by the reaction of [Pb(OAc)2]·3H2O (OAc is acetate) with pyrimidine-2-thione in the presence of triethylamine in methanol. In the crystal structure, the PbIIatom has an N4S4coordination environment with four ligands coordinated by N- and S-donor atoms. This compound shows that the pyrimidine-2-thiolate anion can lead to a three-dimensional network when the coordination number of the metal ion can be higher than 6, as is the case with the PbIIion. This compound presents only covalent bonds, showing that despite the possibility of the hemidirecte

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28

Bhagwanrao, P. V., P. G. Ingole, and S. R. Butle. "SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-PHENYLPYRIDO[2,3-D] PYRIMIDINE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS." INDIAN DRUGS 56, no. 05 (2019): 50–58. http://dx.doi.org/10.53879/id.56.05.11698.

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We report a novel scaffold of 2-phenylpyrido[2,3-d]pyrimidine derivatives designed as structural analogues of dinaciclib. Sixteen derivatives were synthesised and evaluated for their CDK2/5 inhibition activity. Compounds 4-(2-(3-methoxybenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7i) and 4-(2-(3-nitrobenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7n) show promising IC50 and kinase selectivity. These compounds also show moderate anti-proliferative activity in the colon cancer HCT116 and breast cancer MCF7 cell lines. In molecular docking studies with CDK2, compounds 7i a

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29

Xu, Defeng, Zhiling Zhu, and Ziqiao Wang. "A Convenient Synthesis of 4,6-Dimethyl-2-(Methylsulfonyl)Pyrimidine." Journal of Chemical Research 37, no. 12 (2013): 720–21. http://dx.doi.org/10.3184/174751913x13824447710542.

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30

Bassoude, Ibtissam, Sabine Berteina-Raboin, El Mokhtar Essassi, Gérald Guillaumet, and Lahcen El Ammari. "7-Chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 69, no. 5 (2013): o749. http://dx.doi.org/10.1107/s1600536813009896.

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31

Subbagh, Hussein I. El, Li-Jen Ping та Elie Abushanab. "A Stereospecific Synthesis of Pyrimidine β-D-2′-Deoxyribonucleosides". Nucleosides and Nucleotides 11, № 2-4 (1992): 603–13. http://dx.doi.org/10.1080/07328319208021729.

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32

Mohamed, Shaaban K., Mehmet Akkurt, Frank R. Fronczek, Mahmoud A. A. El-Remaily, and Antar A. Abdelhamid. "2-Anilino-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile." Acta Crystallographica Section E Structure Reports Online 68, no. 9 (2012): o2782—o2783. http://dx.doi.org/10.1107/s1600536812035878.

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33

Akcamur, Yunus, Behzat Altural, Emin Saripinar, et al. "A convenient synthesis of functionalized 1H-pyrimidine-2-thiones." Journal of Heterocyclic Chemistry 25, no. 5 (1988): 1419–22. http://dx.doi.org/10.1002/jhet.5570250529.

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34

Shankar, Ravi B., and R. Garth Pews. "Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides." Journal of Heterocyclic Chemistry 30, no. 1 (1993): 169–72. http://dx.doi.org/10.1002/jhet.5570300130.

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35

Quesada, Antonio, Antonio Marchal, Manuel Melguizo, John N. Low, and Christopher Glidewell. "Symmetrically 4,6-disubstituted 2-aminopyrimidines and 2-amino-5-nitrosopyrimidines: interplay of molecular, molecular–electronic and supramolecular structures." Acta Crystallographica Section B Structural Science 60, no. 1 (2004): 76–89. http://dx.doi.org/10.1107/s0108768103024856.

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The structures of six symmetrically 4,6-disubstituted 2-aminopyrimidines, four of them containing a 5-nitroso substituent, have been determined. The nitroso compounds, in particular, exhibit polarized molecular–electronic structures leading to extensive charge-assisted hydrogen bonding. The intermolecular interactions observed include hard hydrogen bonds of N—H...N and N—H...O types together with O—H...O and O—H...N types in 2-amino-4,6-bis(2-hydroxyethylamino)-5-nitrosopyrimidine; soft hydrogen bonds of the C—H...O type in both 2-amino-4,6-bis(morpholino)-5-nitrosopyrimidine (3) and 2-amino-4

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36

Schwade, Vânia Denise, and Bárbara Tirloni. "One- and two-dimensional PbII compounds resulting from reaction of PbBr2 and Pb(SCN)2 with pyrimidine-2-thione." Acta Crystallographica Section C Structural Chemistry 77, no. 7 (2021): 402–10. http://dx.doi.org/10.1107/s2053229621006379.

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Pyrimidine-2-thione (HSpym) reacts with lead(II) thiocyanate and lead(II) bromide in N,N-dimethylformamide (DMF) to form poly[(μ-isothiocyanato-κ2 N:S)(μ4-pyrimidine-2-thiolato-κ6 N 1,S:S:S:S,N 3)lead(II)], [Pb(C4H3N2S)(NCS)] n or [Pb(Spym)(NCS)] n , (I), and the polymeric one-dimensional (1D) compound catena-poly[[μ4-bromido-di-μ-bromido-(μ-pyrimidine-2-thiolato-κ3 N 1,S:S)(μ-pyrimidine-2-thione-κ3 N 1,S:S)dilead(II)] N,N-dimethylformamide monosolvate], {[Pb2Br3(C4H3N2S)(C4H4N2S)]·C3H7NO} n or {[Pb2Br3(Spym)(HSpym)]·DMF} n , (IIa), respectively. Poly[μ4-bromido-di-μ3-bromido-(μ-pyrimidine-2-t

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37

Kalluraya, Balakrishna, Sharatha Kumar, and Priya. "Synthesis and SAR Studies of Some Novel Series of Pyrimidine Analogues." Asian Journal of Chemistry 36, no. 10 (2024): 2397–404. http://dx.doi.org/10.14233/ajchem.2024.32345.

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A series of novel ethyl-4-methyl-6-phenyl-2-(substituted thio)pyrimidine-5-carboxylate (4a-m), ethyl-4-methyl-phenyl-2-(substituted sulfinyl)pyrimidine-5-carboxylate (5a-m) and ethyl-4-methyl-phenyl-2-(substituted sulfonyl)pyrimidine-5-carboxylate (6a-m) were synthesized by multi-step organic synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, LCMS and elemental analysis. Most of the compounds showed significant antibacterial and anticancer activity comparable to or higher than the standard employed.

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38

Wolska, Irena, and Franciszek Herold. "Crystal and Molecular Structure of 4-Arylhexahydro-1H,3H-pyrido[1,2-c]pyrimidine-1,3-dione Derivatives." Zeitschrift für Naturforschung B 57, no. 11 (2002): 1315–19. http://dx.doi.org/10.1515/znb-2002-1118.

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The X-ray crystal structure determination of 4-(2-methylphenyl)hexahydro-1H,3H-pyrido[ 1,2-c]pyrimidine-1,3-dione (2) and 4-(3-methylphenyl)hexahydro-1H,3H-pyrido[1,2-c]- pyrimidine-1,3-dione (3) is reported. The crystal structures show the formation of centrosymmetric dimers via intermolecular N-H···O hydrogen bonds. The saturated ring adopts a slightly distorted halfchair conformation in both 2 and 3. In either compound the planar phenyl ring is twisted with respect to the pyrimidine-1,3-dione fragment.

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39

Li, Hong-Xia, Yu-Su Song, Yong-nian Qu, Jiang-Bing Lu, and Hong-Mei Wang. "Ethyl 2-methyl-6-(propan-2-ylamino)-4-sulfanylidene-3H,11H-pyrimido[1,6-c]quinazoline-1-carboxylate." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1821. http://dx.doi.org/10.1107/s1600536812019952.

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The title compound, C18H22N4O2S, contains a substituted pyrimidine ring fused to both a benzene ring and a substituted thioxopyrimidine ring. The pyrimidine and thioxopyrimidine rings adopt distorted chair conformations. In the crystal, adjacent molecules are linked by pairs of N—H...S and N—H...O hydrogen bonds to generate centrosymmetric R 2 2(8) and R 2 2(16) loops, respectively. This combination leads to [100] chains of molecules.

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40

Nwachukwu, Chideraa I., Leanna J. Patton, Nathan P. Bowling, and Eric Bosch. "Ditopic halogen bonding with bipyrimidines and activated pyrimidines." Acta Crystallographica Section C Structural Chemistry 76, no. 5 (2020): 458–67. http://dx.doi.org/10.1107/s2053229620005082.

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The potential of pyrimidines to serve as ditopic halogen-bond acceptors is explored. The halogen-bonded cocrystals formed from solutions of either 5,5′-bipyrimidine (C8H6N4) or 1,2-bis(pyrimidin-5-yl)ethyne (C10H6N4) and 2 molar equivalents of 1,3-diiodotetrafluorobenzene (C6F4I2) have a 1:1 composition. Each pyrimidine moiety acts as a single halogen-bond acceptor and the bipyrimidines act as ditopic halogen-bond acceptors. In contrast, the activated pyrimidines 2- and 5-{[4-(dimethylamino)phenyl]ethynyl}pyrimidine (C14H13N3) are ditopic halogen-bond acceptors, and 1:1 halogen-bonded cocrysta

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41

Hussein, Khlood Abdulla Ahmed, and Yacoob Abdulla Kassium. "Synthesis and characterization of some New 2- and 6- substituted of 5- Acetyl - 4- (P- phenyl) Pyrimidine and substituted thieno [2, 3- d] Pyrimidine." University of Aden Journal of Natural and Applied Sciences 25, no. 2 (2021): 273–82. http://dx.doi.org/10.47372/uajnas.2021.n2.a05.

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The series of new pyrimidines derivatives 2- and 6- Substituted of 5 - Acetyl - 4 - (P- phenyl) Pyrimidine and Substituted thieno [2, 3- d] Pyrimidine are synthesis by the reaction between some substituted of benzaldehydes with ethyl aceto acetate in the present of ethanol as a solvent to give the products(3e-h), when react alkyl halide with (3e-h) in ethanol obtain new Pyrimidine derivatives(4e-h) heating them with phosphorous oxy chloride in dioxane to form (5e-h) which reacts with thiourea in ethanol to produce (6e-h) these compounds reacting with chloro acetic acid to form new Substituted

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42

Hussein, Khlood Abdulla Ahmed, and Yacoob Abdulla Kassium. "Synthesis and characterization of some New 2- and 6- substituted of 5- Acetyl - 4- (P- phenyl) Pyrimidine and substituted thieno [2, 3- d] Pyrimidine." University of Aden Journal of Natural and Applied Sciences 25, no. 2 (2021): 273–82. http://dx.doi.org/10.47372/uajnas.2021.n2.a05.

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The series of new pyrimidines derivatives 2- and 6- Substituted of 5 - Acetyl - 4 - (P- phenyl) Pyrimidine and Substituted thieno [2, 3- d] Pyrimidine are synthesis by the reaction between some substituted of benzaldehydes with ethyl aceto acetate in the present of ethanol as a solvent to give the products(3e-h), when react alkyl halide with (3e-h) in ethanol obtain new Pyrimidine derivatives(4e-h) heating them with phosphorous oxy chloride in dioxane to form (5e-h) which reacts with thiourea in ethanol to produce (6e-h) these compounds reacting with chloro acetic acid to form new Substituted

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43

Ibrahim, Yusria R. "Synthesis of spiro(cyclohexa-diene-pyrazolo[1,5-a]pyrimidine-4-ylidene)-malononitrile derivatives." Journal of Chemical Research 2009, no. 8 (2009): 495–98. http://dx.doi.org/10.3184/030823409x466717.

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The reaction of 4-substituted aryldiazenyl-1 H-pyrazole-3,5-diamines with 7,7′,8,8′-tetra-cyanoquinodimethane gave 2-(2′,7′-diamino-6′-cyano-3′-(aryldiazenyl)-4′ H-spiro(cyclohexa[2,5]-diene-1,5′-pyrazolo[1,5- a]pyrimidine-4-ylidene) malononitriles in 63–79% yield, while, by reaction of 2-aminobenzimidazole with 7,7′,8,8′-tetracyanoquinodimethane, 2-(3′-amino-4′-cyano-6′ H-spiro-(cyclohexa[2′,5′]diene-1,5′-benzo( d)-imidazo[1,2- a]pyrimidine)-4-ylidene)malononitrile was formed in 71% yield. Rationales for these transformations are presented.

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44

Saldabol, N., J. Popelis, O. Lando, and V. Slavinska. "2-(2-furyl)imidazo[1,2-a]pyrimidine synthesis and electrophilic substitution reactions." Chemistry of Heterocyclic Compounds 42, no. 4 (2006): 495–99. http://dx.doi.org/10.1007/s10593-006-0116-0.

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45

Balzarini, J., C. Pannecouque, E. De Clercq, et al. "Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates." Antimicrobial Agents and Chemotherapy 46, no. 7 (2002): 2185–93. http://dx.doi.org/10.1128/aac.46.7.2185-2193.2002.

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ABSTRACT A novel class of acyclic nucleoside phosphonates has been discovered in which the base consists of a pyrimidine preferably containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy (PMEO) or a 2-(phosphonomethoxy)propoxy (PMPO) group at C-6. The 6-PMEO 2,4-diaminopyrimidine (compound 1) and 6-PMPO 2,4-diaminopyrimidine (compound 11) derivatives showed potent activity against human immunodeficiency virus (HIV) in the laboratory (i.e., CEM and MT-4 cells) and in primary (i.e., peripheral blood lymphocyte and monocyte/macrophage) cell cultures and pronounced activity agai

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46

Wan, Chong-Qing, Zi-Jia Wang, Peng Qiao, Zhi-Wei Wang та Ai-Min Li. "Supramolecular framework incatena-poly[[(nitrato-κO)silver(I)]-μ-(R,S)-2-(pyridin-4-ylsulfinyl)pyrimidine-κ3N,O:N′]". Acta Crystallographica Section C Crystal Structure Communications 68, № 5 (2012): m117—m120. http://dx.doi.org/10.1107/s0108270112015041.

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In the title complex, [Ag(NO3)(C9H7N3OS)]n, η1:η1:η1:μ2-bridging 2-(pyridin-4-ylsulfinyl)pyrimidine (pypmSO) ligands with opposite chiralities are alternately arranged to link the AgIcations through two N atoms and one sulfinyl O atom of each ligand, leading to an extended zigzag coordination chain structure along the [\overline{2}01] direction. An FT–IR spectroscopic study shows a decreased stretching frequency for the η1-O-bonded S=O group compared with that of the free ligand. The parallel chains are arranged and interconnectedviaO(S=O)...π(pyridine/pyrimidine) and C—H(pyridine)...O(NO3−) i

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47

Yavari, Issa, Mahniya Hojati, Leila Azad, and Mohammad Halvagar. "A Synthesis of Spirocyclic Oxazinoisoquinolines and Oxazinoquinolines Bearing Thiazolopyrimidine Moieties." Synlett 29, no. 08 (2018): 1024–27. http://dx.doi.org/10.1055/s-0037-1609302.

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The reaction of isoquinoline or quinoline with dialkyl acetylenedicarboxylates in the presence of alkyl 2-{3,5-dioxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene}acetates (generated in situ from acetylenedicarboxylates and 2-thiouracils) led to dialkyl 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,5H,11b′H-spiro{thiazolo[3,2-a]pyrimidine-3,2′-[1,3]oxazino[2,3-a]isoquinoline}-3′,4′-dicarboxylates or dialkyl 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,4a′H,5H-spiro{thiazolo[3,2-a]pyrimidine-3,2′-[1,3]oxazino[3,2-a]quinoline}-1′,2′-dicarboxylates in good yields. The structure of the target compounds was confirmed

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48

Abou-Elkhair, Reham A. I., Abdalla A. Wasfy, Song Mao, et al. "2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations." New Journal of Chemistry 44, no. 45 (2020): 19650–62. http://dx.doi.org/10.1039/d0nj04154h.

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Synthesis, DFT calculations, and antiviral evaluation of a series of novel 2-hydroxyimino-6-aza-pyrimidine ribonucleosides is reported. The hydrogen bonding between the C<sup>2</sup>N–OH moiety and N<sup>3</sup>–H and/or N<sup>3</sup> moieties shapes the pyrimidine nucleoside as purine.

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49

Sharma, Nidhi, Sanjeev Kumar, Sangit Kumar, S. K. Mehta, and K. K. Bhasin. "Synthesis and characterization of fused imidazole heterocyclic selenoesters and their application for chemical detoxification of HgCl2." New Journal of Chemistry 42, no. 4 (2018): 2702–10. http://dx.doi.org/10.1039/c7nj03908e.

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50

Jiang, Duo Hua, and Gang Liu. "Synthesis and Properties Study of 1-(2,4-Dimethoxyl-5-Pyrimidinyl)-2-[2-Methyl-5-(3-Cyano)-3-Thienyl]Perfluorocyclopentene." Applied Mechanics and Materials 662 (October 2014): 91–94. http://dx.doi.org/10.4028/www.scientific.net/amm.662.91.

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A novel photochromic diarylethene bearing a pyrimidine moiety, 1-(2,4-dimethoxyl-5-pyrimidinyl)-2-[2-methyl-5-(3-cyano)-3-thieny-l] perfluorocyclopentene has been synthesized. Its properties, including photochromic behavior and fluorescent properties, have been investigated. The compound exhibited remarkable photochromism, changing from colorless to blue after irradiation with UV light. The results indicated that the pyrimidine moiety played a very important role during the process of photoisomerization reactions.

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