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1

Zhu, Yu, Jun-Jie Hong, Yun-Bin Zhou, Yu-Wei Xiao, Min Lin, and Zhuang-Ping Zhan. "Selective synthesis of 4-(sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-dihydro-1H-pyrazoles from N-allenic sulfonylhydrazones." Org. Biomol. Chem. 12, no. 23 (2014): 3797–801. http://dx.doi.org/10.1039/c4ob00550c.

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2

Kukharev, B. F., V. K. Stankevich, N. A. Lobanova, G. R. Klimenko, and E. Kh Sadykov. "N-(2-Vinyloxyethyl)-4,5-dihydro-1H-pyrazoles." Russian Journal of Organic Chemistry 43, no. 4 (2007): 628–29. http://dx.doi.org/10.1134/s1070428007040264.

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3

Chovatia, P. T., J. D. Akabari, P. K. Kachhadia, P. D. Zalavadia, and H. S. Joshi. "Synthesis and selective antitubercular and antimicrobial inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole derivatives." Journal of the Serbian Chemical Society 71, no. 7 (2006): 713–20. http://dx.doi.org/10.2298/jsc0607713c.

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The new compounds 1-aryl-3-{1-phenyl-3-[p (methylthio)phenyl]pyrazol-4-yl}-2-propen-1-ones 2a?l were prepared by the condensation of 1-phenyl-3-[p (methylthio)phenyl]-4-formylpyrazole 1 with different aryl ketones. Compounds 2a?l in reaction with hydrazine hydrate yielded 3-aryl-5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4 yl}-4,5-dihydro-(1H)-pyrazoles 3a?l and in the presence of hydrazine hydrate in glacial acetic acid gave 1-acetyl-3-aryl 5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4-yl}-4,5 dihydro-(1H)-pyrazoles 4a?l. These compounds were tested in vitro for their antitubercular and anti
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4

Thirunarayanan, Ganesamoorthy, and K. Ravi. "Synthesis and Spectral Correlation Study of some 3-(3,4-dichlorophenyl)-5-(Substituted Phenyl)-4,5-dihydro-1H-Pyrazole-1-yl-Ethanones." International Letters of Chemistry, Physics and Astronomy 19 (October 2013): 44–57. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.19.44.

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Some N-acetyl pyrazoles including 3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-yl-ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones including substituted styryl 3,4-dichlorophenyl ketones using hydrazine hydrate and acetic anhydride in presence of catalytic amount of fly-ash: H2SO4 catalyst. The yield of these N-acetyl pyrazole derivatives are more than 75%. The synthesised N-acetyl pyrazoline derivatives were characterized by their physical constants and spectral data. The infrared spectral νC=N and C=O (cm-1) frequencies, NMR
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5

Chen, Yi-Hui, Hai-Tao Tang, Jia-Hao Zeng, Jun-Jia Chen, and Zhuang-Ping Zhan. "Synthesis of (E)-4,5-Dihydro-1H-Pyrazoles via Tandem Intermolecular Addition–Cyclization of N-Propargylic Sulfonylhydrazones." Synlett 28, no. 15 (2017): 2036–40. http://dx.doi.org/10.1055/s-0036-1588844.

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A new strategy for the synthesis of (E)-4-benzylidene-4,5-dihydro-1H-pyrazoles through tandem intermolecular addition–intramolecular cyclization of N-propargylic sulfonylhydrazones has been developed. In this study, we firstly report that N-propargylic sulfonylhydrazones react with electrophilic reagents to afford 4-substituted pyrazole derivatives.
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6

Altıntop, Mehlika Dilek. "Synthesis, In vitro and In silico Evaluation of a Series of Pyrazolines as New Anticholinesterase Agents." Letters in Drug Design & Discovery 17, no. 5 (2020): 574–84. http://dx.doi.org/10.2174/1570180816666190618111023.

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Background: Pyrazolines, electron-rich nitrogen carriers, are of great importance due to their potential applications for the treatment of many diseases including inflammation, infectious diseases and neurodegenerative disorders. Objectives: The purpose of this work was to synthesize new pyrazoline derivatives and evaluate their anticholinesterase effects. Methods: 1-Aryl-5-[4-(piperidin-1-yl)phenyl]-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazoles (1-7) were synthesized via the treatment of 1-(3,4-dimethoxyphenyl)-3-[4-(piperidin-1-yl)phenyl]prop-2- en-1-one with arylhydrazine hydrochloride d
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7

Kukharev, B. F., V. K. Stankevich, N. A. Lobanova, V. G. Chernova, E. Kh Sadykov, and V. A. Apkhanov. "Reactions of vinyl 2,3-epoxypropyl ethers with 4,5-dihydro-1H-pyrazoles." Russian Journal of Organic Chemistry 42, no. 10 (2006): 1498–500. http://dx.doi.org/10.1134/s1070428006100174.

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8

Burde, P. C., and A. M. Rahatgaonkar. "Facile Synthesis and Biological Evaluation of Cyclopropyl-Pyrazole Hybrids in [bmim][PF6]-Water Biphasic System as Antifungal Agents." Asian Journal of Organic & Medicinal Chemistry 4, no. 3 (2019): 152–58. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p192.

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3-Cyclopropyl-5-(4-substituted)-1-phenyl-4,5-dihydro-1H-pyrazoles derived from corresponding chalcones were synthesized and evaluated for their biological activities. A convenient synthesis of a library of these compounds in 1-butyl-3-methylimidazolium hexafluorophosphate-water biphasic system at ambient temperature has been accomplished. The ionic liquid, [bmim][PF6] and water which are immiscible, has been easily recycled and reused after separation of the products without any noticeable diminution in its activity.
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9

Venkata Narsimha Reddy, Chintalapani, Eligeti Rajanarendar, and Ananthula Krishnamurthy. "Synthesis of 3-methyl-1,5-diphenyl-7-aryl-7,8-dihydro-6H-pyrazolo[4,5-b]azepines." Collection of Czechoslovak Chemical Communications 55, no. 4 (1990): 1055–58. http://dx.doi.org/10.1135/cccc19901055.

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3,5-Dimethyl-4-nitro-1-phenylpyrazole (I) on treatment with chalcones II under phase transfer conditions gives the Michael adducts, 3-methyl-4-nitro-1-phenyl-5-(2-aryl-4-phenyl-4-oxo-1-butyl)pyrazoles (III). The Michale adducts on cycloreduction with stannous chloride-hydrochloric acid furnish 3-methyl-1,5-diphenyl-7-aryl-7,8-dihydro-6H-pyrazolo[4,5-b]azepines (IV). IR, 1H NMR, 13C NMR and mass spectra support the structures of III and IV.
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10

Ramos, Daniela Fernandes, Gabriela Fiss, Clarissa Piccinin Frizzo, et al. "Activity of 4,5-dihydro-1H-pyrazoles against Mycobacterium tuberculosis and nontuberculous mycobacteria." International Journal of Antimicrobial Agents 43, no. 5 (2014): 481–83. http://dx.doi.org/10.1016/j.ijantimicag.2014.02.004.

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11

Zhu, Yu, Jun-Jie Hong, Yun-Bin Zhou, Yu-Wei Xiao, Min Lin, and Zhuang-Ping Zhan. "ChemInform Abstract: Selective Synthesis of 4-(Sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-Dihydro-1H-pyrazoles from N-Allenic Sulfonylhydrazones." ChemInform 45, no. 44 (2014): no. http://dx.doi.org/10.1002/chin.201444124.

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12

Pasin, J. S. M., A. P. O. Ferreira, A. L. L. Saraiva, et al. "Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats." Brazilian Journal of Medical and Biological Research 43, no. 12 (2010): 1193–202. http://dx.doi.org/10.1590/s0100-879x2010007500139.

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13

Odin, I. S., A. A. Golovanov, V. V. Bekin, and V. S. Pisareva. "Synthesis and Acylation of 3-Aryl-5-(2-phenylethynyl)-4,5-dihydro-1H-pyrazoles." Chemistry of Heterocyclic Compounds 49, no. 11 (2014): 1687–90. http://dx.doi.org/10.1007/s10593-014-1421-7.

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14

Dorn, Helmut, and R�diger Ozegowski. "LINK Synthesis with 3-Hydroxy-1H-pyrazoles: 3-Carboxyisoalkyloxy-1H-pyrazoles - bicyclic acylpyrazolium salts and ?-Lactams - 3-Carboxyisoalkyloxy-4,5-dihydro-1H-pyrazol-5-ones." Journal f�r Praktische Chemie/Chemiker-Zeitung 340, no. 5 (1998): 437–49. http://dx.doi.org/10.1002/prac.19983400506.

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15

Machado, Pablo, Fernanda A. Rosa, Marcelo Rossatto, et al. "Synthesis and structure of novel 4,5-dihydro-1H-pyrazoles: salicylic acid based analgesic agents." Arkivoc 2007, no. 16 (2008): 281–97. http://dx.doi.org/10.3998/ark.5550190.0008.g28.

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16

Pizzuti, Lucas, Luciana A. Piovesan, Alex F. C. Flores, Frank H. Quina, and Claudio M. P. Pereira. "Environmentally friendly sonocatalysis promoted preparation of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles." Ultrasonics Sonochemistry 16, no. 6 (2009): 728–31. http://dx.doi.org/10.1016/j.ultsonch.2009.02.005.

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17

Zhou, Zhixuan, Jiaru Zhuo, Sujun Yan, and Lin Ma. "Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors." Bioorganic & Medicinal Chemistry 21, no. 7 (2013): 2156–62. http://dx.doi.org/10.1016/j.bmc.2012.12.054.

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18

Sviridova, L. A., A. N. Tavtorkin, N. A. Shalynina, et al. "Synthesis of 4,5-dihydro-1H-pyrazoles with chiral substituents at position 3 or 5." Russian Chemical Bulletin 64, no. 5 (2015): 1078–82. http://dx.doi.org/10.1007/s11172-015-0981-8.

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19

Martins, Marcos A. P., Paulo H. Beck, Lilian Buriol, et al. "Evaluation of the synthesis of 1-(pentafluorophenyl)-4,5-dihydro-1H-pyrazoles using green metrics." Monatshefte für Chemie - Chemical Monthly 144, no. 7 (2013): 1043–50. http://dx.doi.org/10.1007/s00706-013-0930-x.

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20

Pang, Wan, Shifa Zhu, Huanfeng Jiang, and Shizheng Zhu. "A novel synthesis of 5-perfluorophenyl 4,5-dihydro-1H-pyrazoles in THF or water." Journal of Fluorine Chemistry 128, no. 11 (2007): 1379–84. http://dx.doi.org/10.1016/j.jfluchem.2007.06.010.

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21

Bharathi, R. "In vitro and molecular docking studies of an antiinflammatory scaffold with human peroxiredoxin 5 and tyrosine kinase receptor." Bioinformation 16, no. 11 (2020): 929–36. http://dx.doi.org/10.6026/97320630016929.

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A new series of 4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile (4a-h) compounds were synthesized and evaluated for in-vitro anti-inflammatory activities. The spectral (IR, NMR) and elemental analyses data of the product indicated the formation of new pyrazoles 4a-h. Compound 4e exhibited potent anti-inflammatory property with 85.45 % inhibitions. This value was compared with standard diclofenac sodium. This data is explained using molecular docking analysis of receptor-ligand binding. These results demonstrated that pyrazole derivatives are p
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22

Khan, Khalid A., and Hassan M. Faidallah. "1-Substituted carbamoyl and thiocarbamoyl-4,5-dihydro-1H-pyrazoles as possible cytotoxic and antimicrobial agents." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. 4 (2015): 619–27. http://dx.doi.org/10.3109/14756366.2015.1057717.

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23

Ratković, Zoran, Jovana Muškinja, Adrijana Burmudžija, et al. "Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity." Journal of Molecular Structure 1109 (April 2016): 82–88. http://dx.doi.org/10.1016/j.molstruc.2015.12.079.

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24

DILIDDO, D., L. BRUCHE, P. BRAVO, D. FAVRETTO, and P. TRALDI. "ChemInform Abstract: Electron-Impact Mass Spectrometry of Trifluoromethyl-Substituted 4,5- Dihydro-1H- and -3H-pyrazoles." ChemInform 24, no. 17 (2010): no. http://dx.doi.org/10.1002/chin.199317044.

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25

Odin, I. S., A. A. Golovanov, V. V. Bekin, and V. S. Pisareva. "ChemInform Abstract: Synthesis and Acylation of 3-Aryl-5-(2-phenylethynyl)-4,5-dihydro-1H-pyrazoles." ChemInform 45, no. 24 (2014): no. http://dx.doi.org/10.1002/chin.201424133.

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26

Moreira, Dayse N., Clarissa P. Frizzo, Kelvis Longhi, Nilo Zanatta, Helio G. Bonacorso, and Marcos A. P. Martins. "An efficient synthesis of 1-cyanoacetyl-5-halomethyl-4,5-dihydro-1H-pyrazoles in ionic liquid." Monatshefte für Chemie - Chemical Monthly 139, no. 9 (2008): 1049–54. http://dx.doi.org/10.1007/s00706-008-0874-8.

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27

Sauzem, Patricia D., Gabriela da S. Sant'Anna, Pablo Machado, et al. "Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats." European Journal of Pharmacology 616, no. 1-3 (2009): 91–100. http://dx.doi.org/10.1016/j.ejphar.2009.06.008.

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28

DORN, H., та R. OZEGOWSKI. "ChemInform Abstract: LINK Synthesis with 3-Hydroxy-1H-pyrazoles: 3-Carboxyisoalkyloxy-1H-pyrazoles - Bicyclic Acylpyrazolium Salts and γ-Lactams - 3-Carboxyisoalkyloxy-4,5-dihydro-1H-pyrazol-5-ones." ChemInform 29, № 46 (2010): no. http://dx.doi.org/10.1002/chin.199846136.

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29

Dhingra, Ashwani Kumar, Bhawna Chopra, Rameshwar Dass, and Sanjeev K. Mittal. "Synthesis and Anti-Inflammatory Activity of Some O-Propargylated-N-acetylpyrazole Derived from 1,3-Diarylpropenones." International Journal of Medicinal Chemistry 2016 (January 11, 2016): 1–6. http://dx.doi.org/10.1155/2016/3156593.

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In search of novel effective potent therapeutic agents delivered by oral route for inflammation treatment, some novel O-propargylated-N-acetylpyrazole analogs (5a–j) were prepared by treating N-acetylpyrazole (4a–j) derived from 1,3-diarylpropenones (3a–j) with propargyl bromide. Claisen-Schmidt condensation of a series of substituted aryl ketones 1 and benzaldehydes 2 in glacial acetic acid afforded 1,3-diarylpropenones which on further treatment with hydrazine hydrate in acetic acid under reflux conditions afforded 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles (4a–j). The products were charac
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30

PALLEAPATI, Kishor, Venkata Ramana KANCHARLAPALLI, and Afzal Basha SHAIK. "Synthesis, characterization and antitubercular evaluation of some new isoxazole appended 1-carboxamido-4,5-dihydro-1H-pyrazoles." Journal of Research in Pharmacy 23, no. 2 (2019): 156–63. http://dx.doi.org/10.12991/jrp.2019.120.

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31

Mitkidou, Sophia, Stelios Papadopoulos, Julia Stephanidou-Stephanatou, Aristides Terzis, and Demetrios Mentzafos. "Unusual reactions between some 1-aroyl-4,5-dihydro-4,4-dimethyl-5-methylene-1H-pyrazoles and ketenes." Journal of Organic Chemistry 55, no. 15 (1990): 4732–35. http://dx.doi.org/10.1021/jo00302a046.

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32

Agre, Neha, Mihir Khambete, Arundhati Maitra, et al. "Exploration of 5‐(5‐nitrothiophen‐2‐yl)‐4,5‐dihydro‐1H‐pyrazoles as selective, multitargeted antimycobacterial agents." Chemical Biology & Drug Design 95, no. 1 (2019): 192–99. http://dx.doi.org/10.1111/cbdd.13624.

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33

Mishra, Anu, Pratibha Rai, Yogesh K. Pandey, Jaya Singh, and Jagdamba Singh. "An Eco-Sustainable Synthetic Approach for 4,5-Dihydro-1H -pyrazoles via DBU Catalysis in Micellar Medium." ChemistrySelect 2, no. 34 (2017): 10979–83. http://dx.doi.org/10.1002/slct.201702400.

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34

Haunert, Frank, Martin H. Bolli, Berthold Hinzen, and Steven V. Ley. "Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (1998): 2235–38. http://dx.doi.org/10.1039/a803609h.

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35

Tessmann, Josiane Weber, Julieti Buss, Karine Rech Begnini, et al. "Antitumor potential of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles in human bladder cancer cells." Biomedicine & Pharmacotherapy 94 (October 2017): 37–46. http://dx.doi.org/10.1016/j.biopha.2017.07.060.

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36

Vorozhtsov, N. I., A. G. Majouga, E. K. Beloglazkina, et al. "Copper(ii) complexes with 3-(2-pyridyl)-4,5-dihydro-1H-pyrazoles: synthesis, structural and electrochemical studies." Russian Chemical Bulletin 63, no. 3 (2014): 657–61. http://dx.doi.org/10.1007/s11172-014-0488-8.

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37

Frizzo, Clarissa P., and et al et al. "ChemInform Abstract: Evaluation of the Synthesis of 1-(Pentafluorophenyl)-4,5-dihydro-1H-pyrazoles Using Green Metrics." ChemInform 44, no. 42 (2013): no. http://dx.doi.org/10.1002/chin.201342112.

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38

Waldo, Jesse P., Saurabh Mehta, and Richard C. Larock. "Room Temperature ICl-Induced Dehydration/Iodination of 1-Acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. A Selective Route to Substituted 1-Acyl-4-iodo-1H-pyrazoles." Journal of Organic Chemistry 73, no. 17 (2008): 6666–70. http://dx.doi.org/10.1021/jo800789p.

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39

Azarifar, Davood, and Azadeh Gharshasbi. "Microwave-promoted Aromatization of 1,3,5-trisubstituted 4,5-Dihydro-1H-pyrazoles by Calcium Hypochlorite under Solvent-free Conditions." HETEROCYCLES 68, no. 6 (2006): 1209. http://dx.doi.org/10.3987/com-06-10701.

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40

Buriol, Lilian, Clarissa P. Frizzo, Dayse N. Moreira, et al. "An E-factor minimized solvent-free protocol for the preparation of 4,5-dihydro-5-(trifluoromethyl)-1H-pyrazoles." Monatshefte für Chemie - Chemical Monthly 142, no. 5 (2011): 515–20. http://dx.doi.org/10.1007/s00706-011-0464-z.

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41

Ishchenko, Roman A., Irina Yu Kargapolova, Natalia А. Orlova, et al. "Polyfluorinated triphenyl-4,5-dihydro-1H-pyrazoles with dendroid arylsulfanyl moieties as donor blocks in donor-acceptor chromophores." Journal of Fluorine Chemistry 248 (August 2021): 109841. http://dx.doi.org/10.1016/j.jfluchem.2021.109841.

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42

Azarifar, Davood, Elahe Nadimi, Ramin Ghorbani-Vaghei, and Behrooz Maleki. "Microwave-assisted oxidation of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles to the corresponding pyrazoles with poly(N,N′-dibromobenzene-1,3-disulfonamide-1,2-ethanediyl)." Mendeleev Communications 16, no. 6 (2006): 330–31. http://dx.doi.org/10.1070/mc2006v016n06abeh002421.

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43

Papadopoulos, Stelios, and Julia Stephanidou-Stephanatou. "Notizen 1,3-Dipolar Cycloadditions of Benzonitrile Oxides to 1-Aroyl-4,5-dihydro-3,4,4-trimethyl-5-methylene-1H-pyrazoles." Liebigs Annalen der Chemie 1985, no. 8 (1985): 1697–703. http://dx.doi.org/10.1002/jlac.198519850815.

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44

MITKIDOU, S., S. PAPADOPOULOS, J. STEPHANIDOU-STEPHANATOU, A. TERZIS, and D. MENTZAFOS. "ChemInform Abstract: Unusual Reactions Between Some 1-Aroyl-4,5-dihydro-4,4-dimethyl-5- methylene-1H-pyrazoles and Ketenes." ChemInform 22, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.199101184.

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45

HAUNERT, F., M. H. BOLLI, B. HINZEN, and S. V. LEY. "ChemInform Abstract: Clean Three-Step Synthesis of 4,5-Dihydro-1H-pyrazoles Starting from Alcohols Using Polymer Supported Reagents." ChemInform 29, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.199851142.

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46

Rodrigo, Eduardo, M. Belén Cid, Christian Roussel, et al. "A Proof of Concept: 2-Pyrazolines (4,5-Dihydro-1H-pyrazoles) Can Be Used as Organocatalysts via Iminium Activation." Letters in Organic Chemistry 13, no. 6 (2016): 414–19. http://dx.doi.org/10.2174/1570178613666160815163117.

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47

Singh, Nisha, Naresh K. Sangwan, and Kuldip S. Dhindsa. "Synthesis and fungitoxic activity of 5-aryl-1-formyl-4,5-dihydro-3-(2-hydroxyphenyl)-1H-pyrazoles and their complexes." Pest Management Science 56, no. 3 (2000): 284–88. http://dx.doi.org/10.1002/(sici)1526-4998(200003)56:3<284::aid-ps128>3.0.co;2-m.

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48

Buriol, Lilian, Clarissa P. Frizzo, Dayse N. Moreira, et al. "ChemInform Abstract: An E-Factor Minimized Solvent-Free Protocol for the Preparation of 4,5-Dihydro-5-(trifluoromethyl)-1H-pyrazoles." ChemInform 42, no. 38 (2011): no. http://dx.doi.org/10.1002/chin.201138118.

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49

Fioravanti, Rossella, Nicoletta Desideri, Mariangela Biava, Luca Proietti Monaco, Laura Grammatica, and Matilde Yáñez. "Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles." Bioorganic & Medicinal Chemistry Letters 23, no. 18 (2013): 5128–30. http://dx.doi.org/10.1016/j.bmcl.2013.07.035.

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Pathak, Vinay, Hardesh K. Maurya, Sandeep Sharma, Kishore K. Srivastava, and Atul Gupta. "Synthesis and biological evaluation of substituted 4,6-diarylpyrimidines and 3,5-diphenyl-4,5-dihydro-1H-pyrazoles as anti-tubercular agents." Bioorganic & Medicinal Chemistry Letters 24, no. 13 (2014): 2892–96. http://dx.doi.org/10.1016/j.bmcl.2014.04.094.

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