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Journal articles on the topic '4-b]-Pyridine; 1'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Grinberga, S., A. Krauze, L. Krasnova, and G. Duburs. "Synthesis of 4-Benzo[1,3]Dioxol-5-Ylthieno-[2,3-b]Pyridines." Latvian Journal of Chemistry 51, no. 1-2 (2012): 143–48. http://dx.doi.org/10.2478/v10161-012-0002-2.

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Synthesis of 4-Benzo[1,3]Dioxol-5-Ylthieno-[2,3-b]Pyridines 4,7-Dihydrothieno[2,3-b]pyridine 4 and thieno[2,3-b]pyridine 6 were obtained by Thorpe-Ziegler cyclization. Mn(OAc)3/acetic acid system had been used for oxidation of 1,4-dihydropyridine 3 to pyridine derivative 5. 6-Carbamoylmethylsulfanyl-1,4-dihydropyridine 3 was prepared by al-kylation of piperidinium 1,4-dihydropyridine-2-thiolate 1 with iodoacet-amide.

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2

Fathi, Anwar Abdulghani, Yassir Shakeeb Al Jawaheri, and Shaimaa Samir Ismaee. "Synthesis of some new substituted imines from aldehydes and ketones derived from quinolinic acid." Ecletica Quimica 48, no. 2 (2023): 49–65. http://dx.doi.org/10.26850/1678-4618eqj.v48.2.2023.p49-65.

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In this paper, some substituted imines compounds have been prepared from quinolinic acid as a starting material. Firstly, the quinolinic acid was treated with acetic anhydride and acetic acid to form furo[3,4-b]pyridine-5,7-dione (1); the resulting compound was heated with urea to form 5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione (2). After that, it was treated with potassium hydroxide to give potassium 5,7-dioxo-5,7-dihydropyrrolo[3,4-b]pyridin-6-dione, which was directly and easily converted to 6-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione (3) by the reaction wit

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3

Norman, Rebecca E., Michael V. Perkins, Andris J. Liepa, and Craig L. Francis. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part X. The First Pyrazolo[1,5-b][1,2,4,6]thiatriazine Derivatives and their Unusual Reactions with Acylating Agents." Australian Journal of Chemistry 66, no. 11 (2013): 1323. http://dx.doi.org/10.1071/ch13282.

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N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 underwent a regioselective reaction with 3-aminopyrazoles 2 to produce pyrazolo[1,5-b][1,2,4,6]thiatriazines 3, representatives of a new ring system. Attempted N-acylation of compounds 3 with acetic anhydride (or chloride) and benzoyl chloride in pyridine, only afforded 5-(pyridin-4-yl)-pyrazolo[1,5-b][1,2,4,6]thiatriazine derivatives 11. The analogous reaction with pyridazine led to the corresponding pyridazin-4-yl derivative.

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4

Gad-Elkareem, Mohamed A. M., Azza M. Abdel-Fattah, and Mohamed A. A. Elneairy. "Pyrazolo[3,4-b]pyridine in heterocyclic synthesis: synthesis of new pyrazolo[3,4-b]pyridines, imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines, and pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines." Canadian Journal of Chemistry 85, no. 9 (2007): 592–99. http://dx.doi.org/10.1139/v07-089.

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Pyrazolo[3,4-b]pyridine derivatives 7 and 9 were synthesized via the reaction of 3-amino-1H-pyrazolo-[3,4-b]pyridine derivative 2 with ω-bromoacetophenones. Reaction of 7 and 9 with Ac2O afforded the imidazo[1',2':1,5]py razolo[3,4-b]pyridine derivative 8 and pyrazolo[3,4-b]pyridine derivative 10, respectively. Reaction of 2 with chloroacetonitrile followed by DMF-DMA gave imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines 4 and 5, respectively. Acetyl acetone and 1,1-dicyano-2,2-dimethylthioethene were reacted with 2 to afford the pyrido[2',3':3,4]pyrazolo-[1,5-a]-pyrimidines 11 and 14, respectively.

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5

Abbas, Ashraf A., Mohamed A. A. Elneairy та Yehia N. Mabkhot. "Versatile Starting Materials for Novel 1,ω-bis(pyridin-4-ylphenoxy)alkanes, and their Corresponding bis(thieno[2,3-b]pyridin-4-ylphenoxy) derivatives". Journal of Chemical Research 2001, № 4 (2001): 124–26. http://dx.doi.org/10.3184/030823401103169388.

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A synthesis is described, starting from p-hydroxybenzaldehyde, of some new bis(activated styrene) derivatives, and their conversion into novel bis(pyridin-4-yl) ethers and bis(thieno[2,3- b]pyridine) derivatives.

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6

Yakovenko, G. G., and M. V. Vovk. "Convenient approaches to the synthesis of 6-amino- and 6-oxoimidazo[4,5-b]pyrazolo[3,4-e]pyridines." Journal of Organic and Pharmaceutical Chemistry 19, no. 1(73) (2021): 10–15. http://dx.doi.org/10.24959/ophcj.21.224583.

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Aim. To develop convenient approaches to the synthesis of 6-amino- and 6-oxoimidazo[4,5-b]pyrazolo[3,4-e]pyridines as promising biologically active scaﬀolds.Results and discussion. It has been found that cyclocondensation of N-Boc-4-aminopyrazole-5-carbaldehydes with creatinine can be used as an eﬀective method for obtaining 6-aminoimidazo[4,5-b]pyrazolo[3,4-e]pyridines previously unknown. For the synthesis of their 6-oxoanalogs, the reaction of 5-aminopyrazolo[4,3-b]pyridine-6-carboxylic acids used in a modifed Curtius rearrangement with diphenylphosphorylazide was successful. This method was

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7

Malik, Siddharth, and Tulasi Yadati. "A Comprehensive Review on IRAK-4 Inhibitors." International Journal of Drug Design and Discovery 5, no. 4 (2025): 1401–4. https://doi.org/10.37285/ijddd.5.4.3.

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Interleukin-1 receptor-associated kinases (IRAKs) are key component in the signal transduction utilized by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), and Toll-like receptors (TLRs). It plays a pivotal role in alleviating chronic inflammatory and autoimmune disorders. IRAK-4 is also known as “master IRAK” due its role in IL-1R/TLR signaling. Various potent series with IRAK4 inhibitory activity have been reported., including Thiazole and Pyridine Amides, Aminobenzimidazoles, Imidazo[1,2-a]pyridines and Imidazo[1,2-b]pyridazine and Indazole inhibitors. Here, we have present

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8

Nasir, Hussain, Ram Dangi Raja, Kumar Sain Devendra, and L. Talesara Ganpat. "Convenient synthesis of 1-N, 7-N-bisethoxyphthalimido-4-(3,5-dimethyl-4- substitutedphenyl-4, 7-dihydro-1H-dipyrazolo[3,4-b;4' ,3' -e ]pyridin-8-yl)phenylamine." Journal of Indian Chemical Society Vol. 88, Jul 2011 (2011): 1021–24. https://doi.org/10.5281/zenodo.5785141.

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Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India <em>E-mail </em>: glntalesara@yahoo.com <em>Manuscript received 22 March 2010, revised 05 October 2010, accepted 30 December 2010</em> In the three component one pot synthesis 5-methyl-2,4-dihydro-3H-pyrazole-3-one reacted with substituted aldehydes and p-phenylenediamine to produce 4-{3,5-dimethyl-4-(substitutedphenyl)-4, 7-dihydro-1H-diprazolo[3,4-b;4<em>'</em> ,3<em>'</em>e] pyridin-8-yl}phenylamine (4a-e). Condensation of (4a-e) with two mole of bro

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9

Ryzhkova, Yuliya E., Fedor V. Ryzhkov, Oleg I. Maslov, and Michail N. Elinson. "2,4-Diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile." Molbank 2023, no. 1 (2023): M1541. http://dx.doi.org/10.3390/m1541.

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5H-Chromeno[2,3-b]pyridines are important compounds with industrial, biological, and medicinal properties. In this short note, the multicomponent reaction of salicylaldehyde, malononitrile dimer, and 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in dimethyl sulfoxide at ambient temperature was investigated to give 2,4-diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile with good yield. The structure of the previously unknown chromeno[2,3-b]pyridine derivative was confirmed by elemental analysis, mass, nuclear magnetic resonan

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10

Selig, Roland, Dieter Schollmeyer, Wolfgang Albrecht, and Stefan Laufer. "4-Chloro-1-(4-methylphenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (2009): o3018. http://dx.doi.org/10.1107/s1600536809044559.

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11

Amr, Abd El-Galil E., Ashraf M. Mohamed, and Alhussein A. Ibrahim. "Synthesis of Some New Chiral Tricyclic and Macrocyclic Pyridine Derivatives as Antimicrobial Agents." Zeitschrift für Naturforschung B 58, no. 9 (2003): 861–68. http://dx.doi.org/10.1515/znb-2003-0908.

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A series of chiral macrocyclic pyridines has been prepared starting from N2,N2-(pyridine- 2,6-dicarbonyl)diamino acid hydrazides (2a-c) and N,N-bis-(1-carboxy-2-substituted)-2,6- diaminocarbonyl)pyridines (3a,b). The coupling of (2a-c) with 2,6-pyridine dicarbonyldichloride (4) gave the compounds (5a-c). Compounds 2a-c were coupled with 2,6-diacetylpyridine (6) to yield compounds (7a-c) and with heterocyclic aldehydes (8) or (10) to give the compounds (9a-c) or (11a-c). In addition, the hydrazides (2a-c) were reacted with diformylcalix[4]arene 12 to afford the macrocyclic calix[4]arene hydrazo

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12

Qiang, Hong, Shu-Jie Tu, and Yong-Li Yang. "Crystal structure of 4-iodobenzoic acid— 4-((pyridin-4-yl)methylthio)- pyridine (1:1), C18H15IN2O2S." Zeitschrift für Kristallographie - New Crystal Structures 229, no. 2 (2014): 121–22. http://dx.doi.org/10.1515/ncrs-2014-0064.

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13

Quiroga, Jairo, Yurina Díaz, Justo Cobo, and Christopher Glidewell. "Hydrogen-bonded assembly in six closely related pyrazolo[3,4-b]pyridine derivatives; a simple chain, three types of chains of rings and a complex sheet structure." Acta Crystallographica Section C Crystal Structure Communications 68, no. 1 (2011): o12—o18. http://dx.doi.org/10.1107/s0108270111050207.

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Six closely related pyrazolo[3,4-b]pyridine derivatives, namely 6-chloro-3-methyl-1,4-diphenylpyrazolo[3,4-b]pyridine-5-carbaldehyde, C20H14ClN3O, (I), 6-chloro-3-methyl-4-(4-methylphenyl)-1-phenylpyrazolo[3,4-b]pyridine-5-carbaldehyde, C21H16ClN3O, (II), 6-chloro-4-(4-chlorophenyl)-3-methyl-1-phenylpyrazolo[3,4-b]pyridine-5-carbaldehyde, C20H13Cl2N3O, (III), 4-(4-bromophenyl)-6-chloro-3-methyl-1-phenylpyrazolo[3,4-b]pyridine-5-carbaldehyde, C20H13BrClN3O, (IV), 6-chloro-4-(4-methoxyphenyl)-3-methyl-1-phenylpyrazolo[3,4-b]pyridine-5-carbaldehyde, C21H16ClN3O2, (V), and 6-chloro-3-methyl-4-(4-n

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14

Krauze, A., Z. Andžāns, and G. Duburs. "Synthesis and Properties of Partially Hydrogenated Ethyl ([3,4']Bipyridin-6'-ylsulfanyl) Acetates." Latvian Journal of Chemistry 49, no. 1-4 (2010): 66–71. http://dx.doi.org/10.2478/v10161-010-0002-z.

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Synthesis and Properties of Partially Hydrogenated Ethyl ([3,4']Bipyridin-6'-ylsulfanyl) Acetates Ethyl 2'-hydroxy-1',2',3',4'-tetrahydro[3,4']bipyridine-3'-carboxylate 3 and the corresponding ethyl 1',4'-dihydro[3,4']bipyridine-3'-carboxylate 4 as potential cardiovascular agents have been prepared by alkylation of 2'-hydroxy-1',2',3',4'-tetrahydro[3,4']bipyridine-6'-thiolate 1 or betaine 2 with ethyl bromoacetate. The treatment of [3,4']bipyridine 4 with KOH/H2O gave diethyl 3-amino-4-(pyridin-3-yl)-4,7-dihydrothieno[2,3-b]-pyridine-2,5-dicarboxylate 5, but subsequent treatment of the remaini

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15

Chaban, Taras, Vasyl Matiychuk, Olexandra Komarytsya, et al. "Anti-inflammatory properties of some novel thiazolo[4,5-b]pyridin-2-ones." Pharmacia 67, no. (3) (2020): 121–27. https://doi.org/10.3897/pharmacia.67.e38969.

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Synthesis of novel N<sup>3</sup> and C<sup>5</sup> substituted thiazolo[4,5-b]pyridin-2-ones was carried out on the basis of [3+3]-cyclocodensation, acylation and alkylation reactions. The structures of the obtained compounds were confirmed by <sup>1</sup>H NMR spectroscopy, and elemental analysis. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. When compared with Ibuprofen, some our compounds were found to be more potent. Graphical abstract

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16

Al-Trawneh, Salah A., Amer H. Tarawneh, Anastassiya V. Gadetskaya, et al. "Synthesis and Cytotoxicity of Thieno[2,3-b]Pyridine Derivatives Toward Sensitive and Multidrug-Resistant Leukemia Cells." Acta Chimica Slovenica 68, no. 2 (2021): 458–65. http://dx.doi.org/10.17344/acsi.2020.6609.

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A new series of substituted ethyl 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates 3a–e were prepared by utilizing ethyl 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (1) and replacing of the 2-chlorine with anions obtained from phenol (2a), salicylaldehyde derivatives 2b–d or thiophenol (2e), leading to the respective ethyl 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates 3a–e. The new compounds were evaluated for their in vitro cytotoxicity towards sensitive CCRF-CEM and mu

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17

Strey, Mark, and Peter G. Jones. "Pyridine 1:1 adducts of urea (Z′ = 1) and thiourea (Z′ = 8)." Acta Crystallographica Section C Structural Chemistry 74, no. 4 (2018): 406–10. http://dx.doi.org/10.1107/s2053229618002632.

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During our studies of urea and thiourea adducts, we noticed that no adducts with unsubstituted pyridine had been structurally investigated. The 1:1 adduct of pyridine and urea, C5H5N·CH4N2O, crystallizes in the P21/c space group with Z = 4. The structure is of a standard type for urea adducts, whereby the urea molecules form a ribbon, parallel to the a axis, consisting of linked R 2 2(8) rings, and the pyridine molecules are attached to the periphery of the ribbon by bifurcated (N—H...)2N hydrogen bonds. The 1:1 adduct of pyridine and thiourea, C5H5N·CH4N2S, crystallizes in the P21/n space gro

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18

Abdel-Rahman, Adel A. H., Amira K. F. Shaban, Ibrahim F. Nassar, et al. "Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity." Molecules 26, no. 13 (2021): 3923. http://dx.doi.org/10.3390/molecules26133923.

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New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylamino derivatives were prepared to obtain the pyridine-‑C2 functionalized derivatives. The derived pyrazolpyridine-N-glycosides were synthesized via heterocyclization of the C2-thioxopyridine derivative followed by glycosylation using glucose and galactose. The furopyridine derivative 14 and the tricy

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19

Holzgrabe, U., B. Piening, K. F. Hesse, H. D. Höltje, and M. Worch. "Stereochemistry of 2,6-Dipyridine Substituted N-Benzyl-4-piperidone Mono- and Dicarboxylates and of the Corresponding Reduction Products." Zeitschrift für Naturforschung B 44, no. 5 (1989): 565–74. http://dx.doi.org/10.1515/znb-1989-0512.

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The alkyl N-benzyl-4-piperidone-3-carboxylate (1) is synthesized by a Mannich procedure from pyridine aldehyde, benzylamine and the monoester of acetonedicarboxylate; the corresponding diester 2 is formed by condensation of pyridine aldehyde, benzylamine and dimethyl 3-oxoglutarate. Isomerism is observed with respect to keto-enol tautomerism and cis or trans substitution of the pyridines. The structure of the enol lb (C24H23N3O3) is determined by X-ray analysis: it crystallizes in the triclinic space group P 1̄ with a = 9.965(2), b = 10.476(2), c = 10.838(2) Å, α = 69.48(1), β/3 = 81.56(1), γ

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20

Nagalakshmi, R. A., J. Suresh, S. Maharani, R. Ranjith Kumar, and P. L. Nilantha Lakshman. "Crystal structures of 2-benzylamino-4-(4-bromophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile and 2-benzylamino-4-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile." Acta Crystallographica Section E Crystallographic Communications 71, no. 1 (2015): 12–15. http://dx.doi.org/10.1107/s2056989014025936.

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In the title compounds, C24H22BrN3, (I), and C24H22ClN3, (II), the 2-aminopyridine ring is fused with a cycloheptane ring, which adopts a half-chair conformation. The planes of the phenyl and benzene rings are inclined to that of the central pyridine ring [r.m.s. deviations = 0.0083 (1) and 0.0093 (1) Å for (I) and (II), respectively] by 62.47 (17) and 72.51 (14)°, respectively, in (I), and by 71.44 (9) and 54.90 (8)°, respectively, in (II). The planes of the aromatic rings are inclined to one another by 53.82 (17)° in (I) and by 58.04 (9)° in (II). In the crystals of both (I) and (II), pairs

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21

Dyall, LK, and WM Wah. "Pyrolysis of Aryl Azides. VI. Identification of Neighbouring Group Effects in Pyrolysis of Azidopyridines and Azidoquinolines." Australian Journal of Chemistry 38, no. 7 (1985): 1045. http://dx.doi.org/10.1071/ch9851045.

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Although there are literature reports of anomalous behaviour on pyrolysis of ortho-nitroazido-pyridines and ortho-nitroazidoquinolines, we find that these compounds cyclize to the expected furazan 1-oxides in near-quantitative yields, and with a high degree of neighbouring group participation by the nitro group. Kinetic studies in decalin solution reveal the following rate enhancements by the ortho-nitro group: 3-azido-2-nitropyridine, 466 at least; 4-azido-3-nitropyridine, 5400; 4-azido-3,5-dinitropyridine, 640; 4-azido-3-nitroquinoline, 82.4; 5-azido-6-nitroquinoline, 27.6; 2-nitro-1-azidona

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22

Dyall, LK, DW Maloney, JJ Harvey, and BE Fulloon. "Oxidative and Thermal Routes to Novel Isoxazolopyridines." Australian Journal of Chemistry 49, no. 7 (1996): 761. http://dx.doi.org/10.1071/ch9960761.

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The novel bicyclic compounds isoxazolo [3,4-b] pyridine (1). 3-phenylisoxazolo [3,4- b] pyridine (2) and 3-phenylisoxazolo[3,4-c]pyridine (3) have been synthesized by oxidative cyclization of the amines 2-aminopyridine-3-carbaldehyde (4), (2-amino-3-pyridyl)phenylmethanone (5) and (3-amino-4-pyridyl)phenylmethanone (6). The oxidant was bis(acetato-O)phenyliodine. 3-Phenylisoxazolo[3,4-c]pyridine (3) was also obtained by thermolysis of 3-azido-4-benzoylpyridine (7). Comparison of the rate of thermolysis of this azide with that of 3-azidopyridine identified a neighbouring group effect (from the

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23

Olczak, Andrzej, Jarosław Sukiennik, Beata Olszewska, Monika Stefaniak, Krzysztof Walczyński, and Małgorzata Szczesio. "Structures 4-n-propyl Piperazines as Non-Imidazole Histamine H3 Antagonists." Materials 14, no. 22 (2021): 7094. http://dx.doi.org/10.3390/ma14227094.

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Seven new low-temperature structures of 4-n-propylpiperazine derivatives, potential H3 receptor antagonists, have been determined by X-ray crystallography, with the following symmetry and unit cell parameters: 2-(4-propyl-piperazin-1-yl)oxazolo[4,5-c]pyridine (compound 1), P-1, 5.9496 Å, 12.4570 Å, 12.8656 Å, 112.445°, 95.687°, 103.040°; 2-(4-propyl-piperazin-1-yl)thia-zolo[4,5-c]pyridine (compound 2), I2/a, 22.2087 Å, 7.5519 Å, 19.9225 Å, β = 92.368°; 2-(4-propyl-piperazin-1-yl)oxazolo[5,4-c]pyridine (compound 3), C2/c, 51.1351 Å, 9.36026 Å, 7.19352 Å, β = 93.882°; 2-(4-propyl-piperazin-1-yl)

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24

Canty, AJ, NJ Minchin, BW Skelton, and AH White. "The Structure of [PdCl2{(Py)2(PyH)CH-N′,N″}][PdCl4]0.5.2H2O (Py = Pyridin-2-yl), a Complex With Protonated 2,2′,2″-Methylidynetrispyridine as a Bidentate Ligand." Australian Journal of Chemistry 45, no. 2 (1992): 423. http://dx.doi.org/10.1071/ch9920423.

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Crystals of dichloro[2,2′,2″-methylidynetris(pyridin)-1-ium-N′,N″]palladium(II) hemi[tetra-chloropalladate(II)] dihydrate are monoclinic, P21/c, a 8.558(5), b 15.516(7), c 16.153(5) a, P 112.07(4)°, Z 4. The cations [PdCl2{(Py)2(PyH)CH-N′,N″}]+ have square-planar geometry for palladium, with the ligand in a boat conformation and having an uncoordinated protonated pyridine group.

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Al‐Refai, Mahmoud, Mohammad Ibrahim, Abdullah Al‐Fawwaz, and Armin Geyer. "Synthesis and characterization of new 4-aryl-2-(2-oxopropoxy)-6-(2,5-dichlorothiophene)nicotinonitrile and their furo[2,3-b]pyridine derivatives: Assessment of antioxidant and biological activity." European Journal of Chemistry 9, no. 4 (2018): 375–81. http://dx.doi.org/10.5155/eurjchem.9.4.375-381.1792.

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A new series of furo[2,3-b]pyridine derivatives bearing aryl substituents were synthesized in two steps, where, the cyano-(2H)-pyridones (1a-l) were converted to the corresponding nicotinonitriles (2a-l), followed by the Thorpe-Ziegler ring cyclization to the furo[2,3-b]pyridine derivatives (3a-l). All new compounds were characterized by 1D-NMR experiments (1H and 13C) and 2D-NMR experiments (COSY, HMBC and HSQC), as well as ESI-MS and HR-ESI-MS data. The new compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) free radical assay. The highest

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26

Surya Prakash Rao, H., Ramalingam Gunasundari, and Jayaraman Muthukumaran. "Crystal structure analysis of ethyl 6-(4-methoxyphenyl)-1-methyl-4-methylsulfanyl-3-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate." Acta Crystallographica Section E Crystallographic Communications 76, no. 8 (2020): 1209–12. http://dx.doi.org/10.1107/s2056989020008841.

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In the title compound, C24H23N3O3S, the dihedral angle between the fused pyrazole and pyridine rings is 1.76 (7)°. The benzene and methoxy phenyl rings make dihedral angles of 44.8 (5) and 63.86 (5)°, respectively, with the pyrazolo[3,4-b] pyridine moiety. An intramolecular short S...O contact [3.215 (2) Å] is observed. The crystal packing features C—H...π interactions.

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Bhukya, Bhadru, and Hanmanthu Guguloth. "Synthesis and Anticancer Activity of Novel Oxadiazole Functionalized Pyrazolo[3,4-b]pyridine Derivatives." Asian Journal of Chemistry 33, no. 6 (2021): 1331–35. http://dx.doi.org/10.14233/ajchem.2021.23183.

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A series of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives (6a-n)was synthesized using 6-thiophenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (1) through reaction with 2-bromoethyl acetate, followed by hydrazine hydrate to afford hydrazide derivatives (5). These compounds were further treated with aromatic acids in the presence of phosphoryl chloride and obtained oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives (6a-n). All the synthesized compounds 6a-n were screened for anticancer activity against four cancer cell lines such as HeLa - cervical can

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28

Goher, M. A. S., M. A. M. Abu-Youssef, F. A. Mautner та H. P. Fritzer. "Crystal Structure Investigation of Two Polymeric Chromium(III) Azide Complexes; KCr(pyridine)4(N3)4 and RbCr(pyridine)3(N3)4. A Structure Containing μ(l,3) and μ(1,1,3) Bridging Azido Ligands between Chromium and Rubidium Centered Polyhedra". Zeitschrift für Naturforschung B 47, № 12 (1992): 1754–58. http://dx.doi.org/10.1515/znb-1992-1219.

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The structures of two polymeric complexes of chromium(III) azide with pyridine, KCr(py)4(N3)4 (1), and RbCr(py)3(N3)4 (2), were determined by X-ray crystallography. Crystal data: 1, C20H20N16CrK, monoclinic, space group C2/c, a = 1611.2(5), b = 1050.6(3), c = 1609.0(5) pm, β = 91.69(3)°, Ζ = 4 and Rw = 0.037 for 923 diffractometer data; 2, C15H15N15CrRb, monoclinic, space group P21/n, a = 1311.9(3), b = 1139.0(4), c = 1523.3(4) pm, β = 109.39(2)°, Ζ = 4 and Rw = 0.046 for 2336 data.The crystal structure of 1 contains six-coordinated chromium and potassium cations with two pyridine ligands and

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29

Nagalakshmi, R. A., J. Suresh, S. Maharani, R. Ranjith Kumar, and P. L. Nilantha Lakshman. "Crystal structure of 2-benzylamino-4-(4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile." Acta Crystallographica Section E Structure Reports Online 70, no. 12 (2014): 525–27. http://dx.doi.org/10.1107/s1600536814024878.

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The title compound, C25H25N3O, comprises a 2-aminopyridine ring fused with a cycloheptane ring, which adopts a chair conformation. The central pyridine ring (r.m.s. deviation = 0.013 Å) carries three substituents,viz.a benzylamino group, a methoxyphenyl ring and a carbonitrile group. The N atom of the carbonitrile group is significantly displaced [by 0.2247 (1) Å] from the plane of the pyridine ring, probably due to steric crowding involving the adjacent substituents. The phenyl and benzene rings are inclined to one another by 58.91 (7)° and to the pyridine ring by 76.68 (7) and 49.80 (6)°, re

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30

Nagalakshmi, R. A., J. Suresh, S. Maharani, R. Ranjith Kumar, and P. L. Nilantha Lakshman. "Isotypic crystal structures of 1-benzyl-4-(4-bromophenyl)-2-imino-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile and 1-benzyl-4-(4-fluorophenyl)-2-imino-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile." Acta Crystallographica Section E Structure Reports Online 70, no. 11 (2014): 344–47. http://dx.doi.org/10.1107/s1600536814022016.

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The molecules of the two isotypic title compounds, C25H24BrN3, (I), and C25H24FN3, (II), comprise a 2-iminopyridine ring fused with a cyclooctane ring. In (I), the cyclooctane ring adopts a twisted chair–chair conformation, while in (II), this ring adopts a twisted boat–chair conformation. The dihedral angles between the planes of the pyridine ring and the bromobenzene and phenyl rings are 80.14 (12) and 71.72 (13)°, respectively, in (I). The equivalent angles in (II) are 75.25 (8) and 68.34 (9)°, respectively. In both crystals, inversion dimers linked by pairs of C—H...N interactions generate

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31

Abdelhamid, Abdou O., and Sobhi M. Gomha. "Synthesis of New Pyrazolo[1,5-a]pyrimidine, Triazolo[4,3-a]pyrimidine Derivatives, and Thieno[2,3-b]pyridine Derivatives from Sodium 3-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-olate." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/327095.

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Condensation of sodium 3-oxo-3-(1-phenyl-1H-pyrazol-4-yl)prop-1-en-1-olate (2) with several heterocyclic amines, cyanoacetamide, cyanothioacetamide, and 2-cyanoacetohydrazide gives pyrazolo[1,5-a]pyrimidines (5a–d), pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine (9), benzo[4,5]imidazo[1,2-a]pyrimidine (10), [1,2,4]triazolo[1,5-a]pyrimidine (11), and pyridine derivatives (12–14). Also, thieno[2,3-b]pyridines (15–18) were synthesized via pyridinethione (13) withα-halo ketones andα-halo ester. Structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, alternat

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32

Abonia, Rodrigo, Emerson Rengifo, Justo Cobo, John N. Low, and Christopher Glidewell. "3-tert-Butyl-4-(4-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine." Acta Crystallographica Section E Structure Reports Online 61, no. 8 (2005): o2625—o2627. http://dx.doi.org/10.1107/s160053680502177x.

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33

Sileo, Elsa E., Daniel Vega, Mará T. Garland, Ricardo Baggio, and Miguel A. Blesa. "Solid State Coordination Chemistry of Pyridinedicarboxylic Acid Isomers. I Copper(II) Disodium Bis(pyridine-2,3- dicarboxylate) Octahydrate and Copper(II) Pyridine-3,4-dicarboxylate 3·5 Hydrate." Australian Journal of Chemistry 52, no. 3 (1999): 205. http://dx.doi.org/10.1071/c98120.

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The crystal structures of Na2Cu(2,3-pydc)2.8H2O (1) and Cu(3,4-pydc).3·5H2O (2) (pydc = pyridinedi- carboxylato) are presented. Compound (1) is monoclinic, space group C 2/c, with a 21·274(1), b 6 ·114(1), c 17·136(1) Å, β 101·62(1)°, Z 4, Dc 1·776 g cm-3 ; compound (2) is also monoclinic, space group P 21/c, with a 7·272(2), b 11·319(3), c 25·453(9) Å, β 90·58(1)°, Z 4, Dc 1·850 g cm-3 . Their stereochemistries are analysed, and compared with other copper(II) pyridine-2,6-dicarboxylates. Ligand constraints are shown to determine the crystal structures and the magnetic properties. Thermal depe

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Maatooq, Galal T., and Joseph J. Hoffmann. "Pyridine Alkaloids From A Parthenium Hybrid." Zeitschrift für Naturforschung C 57, no. 3-4 (2002): 211–15. http://dx.doi.org/10.1515/znc-2002-3-402.

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Two pyridine alkaloids were isolated from the derubberized resin of the hybrid Parthenium argentatum x P. tomentosa. These alkaloids are (±)-N-[4-(1-aminoethyl) phenyl]-4-[3-methylbutenylidine]- 1, 4-dihydropyridine (guayulamine A) and (±)-N-[4-(1-aminoethyl) phenyl]-4- [4-methylpentenylidine]-1, 4-dihydropyridine (guayulamine B). The structures were established by one- and two-dimensional NMR spectroscopy and mass spectrometry

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35

Shooter, Jesse, Caleb J. Allen, Colby W. K. Tinsley, Lev N. Zakharov, and Eric R. Abbey. "Crystal structure and Hirshfield analysis of the 4-(dimethylamino)pyridine adduct of 4-methoxyphenylborane." Acta Crystallographica Section E Crystallographic Communications 73, no. 11 (2017): 1747–50. http://dx.doi.org/10.1107/s2056989017015171.

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The title compound [systematic name: 4-(dimethylamino)pyridine–4-methoxyphenylborane (1/1)], C14H19BN2O, contains two independent molecules in the asymmetric unit. Both molecules exhibit coplanar, mostlysp2-hybridized methoxy and dimethylamino substituents on their respective aromatic rings, consistent with π-donation into the aromatic systems. The B—H groups exhibit an intramolecular close contact with a C—H group of the pyridine ring, which may be evidence of electrostatic attraction between the hydridic B—H and the electropositive aromatic C—H. There appears to be weak C—H...π(arene) intera

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36

Phillip, IG, and PJ Steel. "X-Ray Crystal Structures of 2,2'-Bis(pyrazol-1-yl)-4,4'-bipyridine and a Tetramethyl Derivative; New Bis-bidentate Binucleating Ligands." Australian Journal of Chemistry 48, no. 9 (1995): 1617. http://dx.doi.org/10.1071/ch9951617.

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X-Ray crystal structures of 2,2°-bis(pyrazol-1-yl)-4,4°-bipyridine (3) and 2,2°-bis(3,5-dimethyl-pyrazol-1-yl)-4,4°-bipyridine (4) have been determined at 130 K. Crystals of (3) are triclinic, Pī , a 8.061(1), b 9.024(1), c 10.680(1)Ǻ, α 102.032(8), β 107.931(6), γ 107.355(7)°, Z = 2; the structure was refined to a conventional R(I > 2σ(I)) = 0.0273. Crystals of (4) are orthorhombic, P 212121, a 7.077(2), b 13.906(4), c 16.697(5) Ǻ, Z = 4; the structure was refined to a conventional R(I > 2σ(I)) = 0.0386. In both molecules there is significant (33�1°) twisting about the central pyridine-

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37

Vadlakonda, Rajashekar, Sreenivas Enaganti, and Raghunandan Nerella. "INSILICO DISCOVERY OF HUMAN AURORA B KINASE INHIBITORS BY MOLECULAR DOCKING, PHARMACOPHORE VALIDATION AND ADMET STUDIES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 165. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.14974.

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Objectives: To predict the anticancer potentiality of some newly designed azaindole derivatives gainst human Aurora B kinase and to identify the critical features important for their activity.Methods: Initially, the derivatives of azaindoles, (Z)-2-(oxo-1 H-pyrrolo [2,3-b] pyridine-3 (2H)-ylidene)-N-(p-substituted) hydrazine carbothioamide (scaffold A), (E)-3-((E)-substituted benzylidene hydrazono)-1H-pyrrolo[2,3-b]pyridine-2(3H)-one (scaffold B), and 1-(2-substituted acetyl)-1H- pyrrolo [2,3-b]pyridine-2,3-dione are synthesized and sketched using ACD/ChemSketch (12.0). With the 3D converted c

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38

SLYVKA, Nataliia, Lesya SALIYEVA, Serhii HOLOTA, Ella KADYKALO, Larysa MARUSHKO та Mykhailo VOVK. "SYNTHESIS AND ANTIEXUDATIVE ACTIVITY OF N-ОXIDES 4-PYRIDINYLOXYSUBSTITUTED (BENZO)IMIDAZO[2,1-b][1,3]THIAZINES". Proceedings of the Shevchenko Scientific Society. Series Сhemical Sciences 2022, № 70 (2022): 102–9. http://dx.doi.org/10.37827/ntsh.chem.2022.70.102.

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The imidazo[2,1-b][1,3]thiazine nucleus, as well as the pyridine-N-oxide fragment, are pharmacophore groups that have received much attention from researchers. That is why the combination of these scaffolds in the structure of a single molecule seems to be quite attractive from chemical and biological point of view. Synthetically available 4-pyridinyloxy-substituted (benzo)imidazo[2,1-b]thiazines were used as precursors to obtain previously unknown (benzo)imidazo[2,1-b][1,3]thiazin-6-yloxypyridine 1-oxides. It was found that the oxidation of the latter with m-chlorobenzoic acid under mild reac

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39

Galvez, Enrique, Isabel Iriepa, Antonio Lorente, Jose Miguel Mohedano, Feliciana Florencio, and Severino Garcia-Blanco. "Synthesis and structural study of aminals derived from 8-aminoquinoline and 1-aminonaphtalene." Canadian Journal of Chemistry 65, no. 4 (1987): 687–92. http://dx.doi.org/10.1139/v87-117.

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Reaction of 8-aminoquinoline with pyridine-2-carboxaldehyde (2), pyridine-3-carboxaldehyde (3), pyridine-4-carboxaldehyde (4), and benzaldehyde (5) yields the corresponding aminals or Schiff's bases according to reaction conditions; analogous results are obtained from the reaction of 1-amino-naphtalene with pyridine-2-carboxaldehyde (6). On the other hand, reaction of 8-aminoquinoline with thiophene-2-carboxaldehyde or pyrrole-2-carboxaldehyde yields neither the aminal nor the Schiff's base. Crystals of 4 (C24H19N5) belong to the triclinic space group [Formula: see text]. Cell dimensions are a

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40

Kwiatkowski, Adam, Erkki Kolehmainen, and Borys Ośmiałowski. "Conformational and Tautomeric Control by Supramolecular Approach in Ureido-N-iso-propyl,N’-4-(3-pyridin-2-one)pyrimidine." Molecules 24, no. 13 (2019): 2491. http://dx.doi.org/10.3390/molecules24132491.

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Ureido-N-iso-propyl,N’-4-(3-pyridin-2-one)pyrimidine (1) and its 2-methoxy pyridine derivative (1Me) has been designed and prepared. The conformational equilibrium in urea moiety and tautomerism in the pyrimidine part have been investigated by variable temperature and 1H NMR titrations as well as DFT quantum chemical calculations. The studied compounds readily associate by triple hydrogen bonding with 2-aminonaphthyridine (A) and/or 2,6-bis(acetylamino)pyridine (B). In 1, the proton is forced to 1,3-tautomeric shift upon stimuli and keeps it position, even when one of the partners in the compl

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41

Jiang, Hong, Shu-Jiang Tu, and Song-Lei Zhu. "3-Methyl-4-(4-nitrophenyl)-6-oxo-1-phenyl-4,5-dihydropyrazolo[3,4-b]pyridine." Acta Crystallographica Section E Structure Reports Online 61, no. 7 (2005): o2074—o2075. http://dx.doi.org/10.1107/s1600536805017800.

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42

Zhang, Xin-Ying, Xiao-Yan Li, Xia Wang, Xue-Sen Fan, and Gui-Rong Qu. "6-Amino-3-methyl-4-(4-nitrophenyl)-1-phenylpyrazolo[3,4-b]pyridine-5-carbonitrile." Acta Crystallographica Section E Structure Reports Online 64, no. 4 (2008): o689. http://dx.doi.org/10.1107/s1600536808006156.

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43

Hückstädt, Heiner, and Heiner Homborg. "Synthese von Bis[pyridin-phthalocyaninato(1,5-)iridium(II)]iodid und Pyridin-iodo-phthalocyaninato(2-)iridium(III)-Pyridin durch schrittweise Oxydation von Bis[pyridin-phthalocyaninato(2-)iridium(II)]/Synthesis of Bis[pyridine-phthalocyaninato(1,5-)iridium(II)] Iodide and Pyridine-iodo-phthalocyaninato(2-)iridium(III)-Pyridine by Successive Oxidation of Bis[pyridine-phthalocyaninato(2-)iridium(II)]." Zeitschrift für Naturforschung B 52, no. 6 (1997): 728–34. http://dx.doi.org/10.1515/znb-1997-0610.

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Abstract Successive oxidation of bis[pyridine-phthalocyaninato(2-)iridium(II)] with iodine first yields mixed-valent bis[pyridine-phthalocyaninato(1,5-)iridium(II)] iodide ([(Ir(py)pc1.5-}2]I) and then pyridine-iodo-phthalocyaninato(2-)iridium(III)-pyridine ([Ir(py)(I)pc2-]·py). The latter crystallizes monoclinically with the following cell parameters: a = 10.258(1) Å, b = 17.589(3) Å, c = 19.723(2) Å, β = 92.95(1)°, space group P21/n, Z = 4. IrIII is in the centre of a slightly distorted pc2- ligand and coordinates pyridine and iodide in a trans-arrangement. The average Ir-Niso distance is 1.

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44

Chaban, Taras, Volodymyr Ogurtsov, Anatoliy Mahlovanyy, et al. "Antioxidant properties of some novel derivatives thiazolo[4,5-b] pyridine." Pharmacia 66, no. (4) (2019): 171–80. https://doi.org/10.3897/pharmacia.66.e36764.

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The synthesis and determination of the antioxidant activity of some novel (5,7-dimethyl-2-oxo-thiazolo[4,5-b]pyridine-3-yl)-acetic acid hydrazide derivatives are described in this article. The transformation of the base heterocycle was carried out via the reactions of acylation, [2+3]cyclocondensation, Knoevenagel condencation and alkylation for the purpose to obtain substances with a satisfactory pharmacological profile. Antioxidant activity of the synthesized compounds was evaluated in vitro by means of the scavenging metod effect on 2,2 diphenyl-1-picrylhydrazyl (DPPH) radicals.

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45

Stritt, Anika, E. Alper Ünal, Elisabeth Irran, and Andreas Grohmann. "“Coordination caps” of graded electron-donor capacity." Zeitschrift für Naturforschung B 79, no. 12 (2024): 705–22. https://doi.org/10.1515/znb-2024-0093.

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Abstract An efficient synthesis of the novel {6-[1,1-di(pyridin-2-yl)ethyl]pyridine-2-yl}2-methyl-1,3-propanediamine (2) is reported, as well as a reliable large-scale synthesis (of the order of 100 g) of previously known 2,2’-[1-(6-chloropyridin-2-yl)ethane-1,1-diyl]dipyridine (4); the latter is the starting material for the preparation of the former, as well as a multitude of other polypodal polyamine/polyimine ligands. Both materials, as well as the intermediates in their multi-step syntheses, have been fully characterised. Ligand 2, in conjunction with ligands 2,2’-(pyridine-2,6-diyl)bis(2

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46

Graham, AJ, PC Healy, JD Kildea, and AH White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. XLVI. Synthesis and Conformational Systematics of Some Novel Polymeric Adducts of Pyridine-4-carbonitrile With Copper(I) Halides." Australian Journal of Chemistry 42, no. 1 (1989): 177. http://dx.doi.org/10.1071/ch9890177.

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The isolation and structural characterization of 1 : 1 adducts of copper(1) chloride (1) and bromide (2) with pyridine-4-carbonitrile (L) is described; crystals of the two complexes are isomorphous (monoclinic, P21/c, a ≈ 3.9, b ≈ 14.7, c ≈ 13.0 � , β ≈ 96°, Z 4; R0.047, 0.063 for No 630, 707 'observed' reflections respectively). Unlike the 1 : 1 adducts with the parent pyridine and benzonitrile ligands which are 'stair' polymers, these complexes comprise 'split-stair' strands woven into a two-dimensional sheet by crosslinking ambidentate ligands. Cu-N ( nitrile ) (1.942(9), 1.96(1) � ) are ap

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47

Girgis, Adel S., and I. S. Ahmed-Farag. "Synthesis of Novel 2-Alkoxy-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-carbonitriles." Zeitschrift für Naturforschung B 58, no. 7 (2003): 698–703. http://dx.doi.org/10.1515/znb-2003-0716.

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Reaction of 6-arylmethylene-6,7,8,9-tetrahydro-5H-benzocyclo-hepten-5-ones (1) with malononitrile in the appropriate alcohol in the presence of sodium afforded the corresponding 2-alkoxy-4-aryl- 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-carbonitriles (2) and not their isomeric forms 2-alkoxy-4-aryl-6,7-dihydro-5H-benzo[3,4]-cyclohepta[1,2-c]pyridine-1-carbonitriles (3). The proposed structure was confirmed via independent synthesis of (2) through the reaction of 6,7,8,9- tetrahydro-5-benzocycloheptenone (4) with the appropriate ylidenemalononitriles 5 under the same reaction conditi

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48

Abd Al-Jabbar, Shatha, Hussein Ali Al-Bahrani, Hussein Abd Aljabbar Ismael, et al. "Synthesis, Anticancer Evaluation and Molecular Docking of Novel Imidazo[1,2-a]pyridine Derivatives." Asian Journal of Chemistry 37, no. 6 (2025): 1339–45. https://doi.org/10.14233/ajchem.2025.33718.

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Imidazo[1,2-a]pyridine and its derivatives are widely recognized for their antifungal and anti-yeast activities, primarily through ergosterol synthesis inhibition. In this study, an efficient and high-yield synthesis route is presented for three novel imidazo[1,2-a]pyridine derivatives based on 1-(4-phenoxyphenyl)ethan-1-one. These compounds were synthesized by reacting 1-(4-phenoxyphenyl)ethan-1-one with pyridin-2-amine in presence of iodine as a cyclizing agent and ethanol. The structures of the synthesized compounds (A, B and C) were confirmed by spectroscopic techniques, including FT-IR, 1

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49

Nishiyama, Takashi, Shota Mizuno, Yuhzo Hieda, and Tominari Choshi. "Progress on the Synthesis of the Aromathecin Family of Compounds: An Overview." Molecules 29, no. 10 (2024): 2380. http://dx.doi.org/10.3390/molecules29102380.

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We present a systematic review of the methods developed for the synthesis of the aromathecin family of compounds (benz[6,7]indolizino[1,2-b]quinolin-11(13H)-ones) and their derivatives. These methods can be broadly classified into four categories based on the construction of pentacyclic structures: Category 1: by constructing a pyridone moiety (D-ring) on the pyrroloquinoline ring (A/B/C-ring), Category 2: by constructing a pyridine moiety (B-ring) on the pyrroloisoquinolone ring (C/D/E-ring), Category 3: by constructing an indolizidinone moiety (C/D-ring) in a tandem reaction, and Category 4:

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50

Seck, Gorgui Awa, Mamour Sarr, Mbosse Ndiaye Gueye та ін. "Synthesis, Characterization and Crystal Structure of Bis[4-Methyl-1-{1-(Pyridin-2-Yl)Ethylidene} Thiosemicarbazide-Κ3s,N,N]Zinc(II)". Chemical Science International Journal 33, № 6 (2024): 91–101. http://dx.doi.org/10.9734/csji/2024/v33i6928.

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Schiff base ligand (4-methyl-1-(1-(pyridin-2-yl)ethylidene)thiosemicarbazide (H2L) was synthesized via condensation of 2-acetylpyridine and 4-methyl-3-thiosemicarbazide in ethanol. The Zn(II) complex was obtained from 2:1 (H2L/Zn(OAc)2.2H2O) molar ratio reaction, yielding a neutral compound formulated as [Zn(HL)2]. Elemental analysis, 1H and 13C NMR, conductance measurements and FT-IR spectroscopy were used for the characterization of the ligand and the complex. The complex is non-electrolyte in DMF solution. The structure of the complex was determined by single crystal X-ray diffraction study

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