Relevant bibliographies by topics / 5-a]pyrimidine

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  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '5-a]pyrimidine'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "5-a]pyrimidine"

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Ho, Yuh-Wen, and Maw Cherng Suen. "Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives." Journal of Chemistry 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/765243.

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A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio)pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine, 6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds, respectively. The structur
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Ossipov, D., E. Zamaratski, and J. Chattopadhyaya. "The 5′-Purine-Pyrimidine-3′ Stacks are More Stabilizing in a Self-3′-Pyrinudine-Purine-5′ complementary DNA Duplex than the 5′-Purine-Purine-3′ 3′-Pyrimidine-Pyrimidine-5′ Stack." Nucleosides and Nucleotides 17, no. 9-11 (1998): 1613–16. http://dx.doi.org/10.1080/07328319808004693.

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Zerez, Charles R., and Kouichi R. Tanaka. "A continuous spectrophotometric assay for pyrimidine-5′-nucleotidase." Analytical Biochemistry 151, no. 2 (1985): 282–85. http://dx.doi.org/10.1016/0003-2697(85)90176-9.

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Shanmugasundaram, Muthian, Annamalai Senthilvelan, and Anilkumar R. Kore. "C-5 Substituted Pyrimidine Nucleotides/Nucleosides: Recent Progress in Synthesis, Functionalization, and Applications." Current Organic Chemistry 23, no. 13 (2019): 1439–68. http://dx.doi.org/10.2174/1385272823666190809124310.

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The chemistry of C5 substituted pyrimidine nucleotide serves as a versatile molecular biology probe for the incorporation of DNA/RNA that has been involved in various molecular biology applications such as gene expression, chromosome, and mRNA fluorescence in situ hybridization (FISH) experiment, mutation detection on arrays and microarrays, in situ RT-PCR, and PCR. In addition to C5 substituted pyrimidine nucleotide, C5 substituted pyrimidine nucleoside displays a broad spectrum of biological applications such as antibacterial, antiviral and anticancer activities. This review focusses on the
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Huppatz, JL. "Systemic Fungicides. The Synthesis of Pyrazolo[1,5-a]pyrimidine Analogues of Carboxin." Australian Journal of Chemistry 38, no. 1 (1985): 221. http://dx.doi.org/10.1071/ch9850221.

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The synthesis of a series of pyrazolo [1,5-a] pyrimidine derivatives, structural analogues of the systemic fungicide carboxin, is described. A common intermediate incorporating structural features desirable for fungicidal activity, N-phenyl-3(5)-amino-5(3)-methylpyrazole-4- carboxamide (6), was used to prepare pyrazolo [1,5-a] pyrimidines variously substituted in positions 5 and 7 of the ring system. Bromination of N-phenyl-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide (8) occurred preferentially in the phenyl ring and the 6-bromo derivative was prepared by bromination of the corresponding 3
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Yakovlev, Dmitry S., Pavel M. Vassiliev, Yana V. Agatsarskaya, et al. "Searching for novel antagonists of adenosine A1 receptors among azolo[1,5-a]pyrimidine nitro derivatives." Research Results in Pharmacology 8, no. (2) (2022): 69–75. https://doi.org/10.3897/rrpharmacology.8.77854.

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Introduction: Ligands of adenosine A<sub>1</sub>Rs are potential candidates for the development of drugs for the treatment of paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At the same time, there is a deficiency of drugs that can regulate the functions of A<sub>1</sub> receptors. A number of A<sub>1</sub>-antagonists are at the various stages of clinical trials; other drugs are not very selective or are characterized by an insufficient breadth of their therapeutic action. Therefore, the search for
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V. VOSTRIKOVA, Tatiana, Vladislav N. KALAEV, Andrey Yu POTAPOV, Dmitry Y. VANDYSHEV, and Khidmet S. SHIKHALIEV. "USING SYNTHESISED ORGANIC COMPOUNDS AS ENVIRONMENTALLY FRIENDLY RETARDANTS FOR ORNAMENTAL PLANTS." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 28, no. 28 (2020): 40–44. http://dx.doi.org/10.48141/sbjchem.v28.n28.2020.06_vostrikova_pgs_40_44.pdf.

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The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the gre
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Vostrikova, Tatiana, Vladislav Kalaev, Andrey Potapov, Dmitry Vandyshev, and Khidmet Shikhaliev. "Using Synthesised Organic Compounds as Environmentally Friendly Retardants for Ornamental Plants." Southern Brazilian Journal of Chemistry 28, no. 28 (2020): 40–44. http://dx.doi.org/10.37633/sbjc.28(28)2020.40-44.

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The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2- piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the gr
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Dorn, Helmut, and Alfred Zubek. "Pyrazolo [1, 5-a]pyrimidine aus 3 (5)-Amino-pyrazol und Acetessigester." Zeitschrift für Chemie 7, no. 9 (2010): 343. http://dx.doi.org/10.1002/zfch.19670070908.

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Dragon, Stefanie, Rainer Hille, Robert Götz, and Rosemarie Baumann. "Adenosine 3′:5′-Cyclic Monophosphate (cAMP)-Inducible Pyrimidine 5′-Nucleotidase and Pyrimidine Nucleotide Metabolism of Chick Embryonic Erythrocytes." Blood 91, no. 8 (1998): 3052–58. http://dx.doi.org/10.1182/blood.v91.8.3052.3052_3052_3058.

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Terminally differentiating erythrocytes degrade most of their RNA with subsequent release of mononucleotides. Pyrimidine mononucleotides are preferentially cleaved by an erythrocyte-specific pyrimidine 5′-nucleotidase; deficiency of this enzyme causes hemolytic anemia in humans. Details of the regulation of its activity during erythroid differentiation are unknown. The present study arose from the observation that the immature red blood cells (RBCs) of mid-term chick embryos contain high concentrations of uridine 5′-triphosphate (UTP) (5 to 6 mmol/L), which decline rapidly from days 13 to 14 o
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Dissertations / Theses on the topic "5-a]pyrimidine"

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Bassoude, Ibtissam. "Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00789954.

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Nos travaux de thèse portent sur la mise au point de nouvelles méthodes de synthèse permettant l'accès de façon rapide et efficace à différents dérivés pyrazolo[1,5-a]pyrimidiniques diversement fonctionnalisés.La première partie de ce travail concerne l'étude et l'application de la condensation de la pyran-2-one avec les 5(3)-amino-3(5)-arylpyrazoles que ce soit par chauffage classique ou sous irradiation micro-onde. Par la suite, un nouveau procédé d'(hétéro)arylation pallado-catalysé direct régiosélectif a été mis à profit pour élaborer des pyrazolo[1,5-a]pyrimidines fonctionnalisées tant en
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Book chapters on the topic "5-a]pyrimidine"

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of trans-aquatrichlorobis-(5, 7-dimethyl[1, 2, 4]triazolo[1, 5-a]pyrimidine-N3)-ruthenium(III) monohydrate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_231.

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Liu, Wei, Xiaoli Wu, Zheng Gao, and Lingling Xia. "Minimally Invasive Technologies for Treatment of HTS and Keloids: Low-Dose 5-Fluorouracil." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_30.

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AbstractBoth hypertrophic scar (HTS) and keloid are pathological scars that tend to overgrow and overproduce extracellular matrices, lead to large-sized scars along with severe pain and itching, and even result in functional disability. In particular, keloids are considered as benign skin tumors due to their nature of uncontrolled growth beyond the original wound boundary and invasion into normal skin; therefore, anticancer therapy has been employed in keloid therapy. 5-Fluorouraci (5-FU), a pyrimidine analog, is a commonly used chemotherapy agent and it has also been previously used in keloid
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Usami, Makoto, Jian-Hua Zheng, Jianping Wang, et al. "Utilization of Purine and Pyrimidine in Human Gastric Cancer Cells (Kato III): Effect of a Nucleotide and Nucleosides Mixture (OG-VI) Solution on Proliferation with Coadministration of 5-Fluorouracil." In Purine and Pyrimidine Metabolism in Man VIII. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_30.

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Franklin, Trevor J., Gwynneth Edwards, and Philip Hedge. "Inosine 5’-Monophosphate Dehydrogenase as a Chemotherapeutic Target." In Purine and Pyrimidine Metabolism in Man VIII. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_35.

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Bontemps, F., G. Van den Berghe, and H. G. Hers. "Identification of a Purine 5′-Nucleotidase in Human Erythrocytes." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_45.

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Snyder, Floyd F., Jack P. Jenuth, Janet L. Noy, and Ernest Fung. "Mapping a Gene that Determines Erythrocytic Guanosine-5’-Triphosphate Concentration (Gtpc) on Mouse Chromosome 9." In Purine and Pyrimidine Metabolism in Man VIII. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_153.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of a nonanuclear nickel(II) cluster with a 1,2,4-triazolo[4,3-a]pyrimidine derivative." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_352.

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Nyhan William L. and Friedmann Theodore. "Disorders of Nucleotide Metabolism: Purines and Pyrimidines." In Metabolic Diseases. IOS Press, 2017. https://doi.org/10.3233/978-1-61499-718-4-441.

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The disorders of purine metabolism encompass a spectrum of clinical abnormalities. Striking features are the hyperuricemia, neurologic abnormalities and unusual behavior of Lesch-Nyhan disease. Renal stone disease and deafness characterize PRPP deficiency and xanthine oxidase deficiency, as well as in orotic aciduria. In purine nucleotide phosphorylase deficiency and adenosine deaminase deficiency, there is defective immune function. Patients with deficiency of adenylosuccinase have seizures and delayed development. Myoadenylate deaminase deficiency causes myopathy. Hypouricemia is found in xa
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"Purine- and Pyrimidine-derived Natural Products." In Natural Product Biosynthesis. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/bk9781839165641-00316.

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Pyrimidine- and purine-based natural products could qualify as alkaloids (e.g. caffeine) but we take up these nucleoside natural products as a separate subclass, given the centrality of uracil/5-methyluracil, cytosine, adenine, and guanine in nucleic acid metabolism, and as starting points for varied nucleoside scaffolds and their roles as plant signaling molecules and natural antiviral and/or antibacterial agents. In the core tripartite structure of nucleobase, d-ribose sugar, and 5′-carbon substituent, one can find metabolites with altered nucleobase heterocycles (e.g. 7-deazguanines), alter
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Ozaki, Hiroaki, Masayasu Kuwahara, and Hiroaki Sawai. "Oligonucleotides Bearing a 5-Substituted Pyrimidine Nucleoside: Their Synthesis, Properties, and Application." In Frontiers in Organic Chemistry. BENTHAM SCIENCE PUBLISHERS, 2009. http://dx.doi.org/10.2174/907752706010501010063.

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Conference papers on the topic "5-a]pyrimidine"

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Shutalev, Anatoly, Ekaterina Kishko, and Natalie Sivova. "A New Approach to 5-Functionalized Pyrimidine-2-Thiones." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02012.

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Avdović, Edina, Dušica Simijonović, Žiko Milanović, Sandra Jovičić Milić, Sunčica Roca, and Dražen Vikić-Topić. "Chromeno-pyrimidine-type compounds (part II): in vitro evaluation of antioxidant potential." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.690a.

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The chromeno and pyrimidine classes compounds include a variety of hybrid molecules displaying diverse biological actions. Although they have been examined for many years, these compounds are still of interest due to their facile chemical transformations. The presence of chromeno and pyrimidine structural motifs in many drugs, prompted us to investigate the antioxidant features of compounds 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl) pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) and 8,9- ihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2). In this paper, we inv
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Lyapustin, D. N., E. N. Ulomsky, E. K. Voinkov, and V. L. Rusinov. "Preparation of new 5-methylthio-6-nitro-1,2,4-triazolo[1,5-a]pyrimidine-7-ones as structural analogues of antiviral drugs." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087320.

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Prasad, N. L., M. S. Krishnamurthy, and Noor Shahina Begum. "Crystal structure studies of methyl 3-amino-2-cyano-5-(2-fluoro-phenyl)-7-methyl-5H-thiazolo [3,2-a]pyrimidine-6-carboxylate." In WORLD MULTIDISCIPLINARY CIVIL ENGINEERING-ARCHITECTURE-URBAN PLANNING SYMPOSIUM WMCAUS 2022. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0174743.

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Mitchell-Ryan, Shermaine K., Yiqiang Wang, Christina Cherian, et al. "Abstract 3822: A tumor-targeted 5-pyrrolo[2,3-d]pyrimidine antifolate is a selective substrate for folate receptor ≤ and potent inhibitor of 5-amino-4-carboxamide formyltransferase inde novopurine nucleotide biosynthesis." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3822.

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Nikalje, Anna Pratima, Julio Seijas Vázquez, Shailee Tiwari, and Zahid Zaheer. "Ultrasound-promoted One-Pot, Three Component Synthesis Of Novel 5-Amino-2-(4-Chlorophenyl)-7- Substituted Phenyl-8,8a-Dihydro-7H-[1,3,4]Thiadiazolo[3,2-A]Pyrimidine-6-Carbonitrile Derivatives." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a048.

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Engasheva, E. S., and D. D. Novikov. "THE EFFICACY OF THE COMBINATION DRUG AGAINST APHANIPTEROSIS IN CATS." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2025. https://doi.org/10.31016/978-5-6053355-1-1.2025.26.100-104.

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The insecticidal efficacy and safety of a new combination drug in tablet formulation based on derivatives of spinosyns, pyrimidines and pyrazinoisoquinoline against aphanipterosis in cats was studied. The study was carried out on 16 animals with spontaneous infestation with fleas Ctenocephalides spp. which were divided into two groups: experimental and control groups of 8 animals each. The animals of the experimental group were given the drug individually, once, orally, on the root of the tongue immediately after feeding in the minimum dose per 1 kg of animal weight (by active ingredients): 50
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Mima, Shinji, Hiroki Nishikawa, Shinichi Watanabe, et al. "Abstract 5127:In vitroandin vivoevaluation of FF-10502-01, a new pyrimidine nucleoside analogue." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5127.

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Ghazaly, Essam A., Magdalena Slusarczyk, Christopher McGuigan, David Harrison, and Sarah P. Blagden. "Abstract B46: NUC-3373: A novel pyrimidine nucleotide analogue that overcomes key cancer drug resistance limiting patient survival." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-b46.

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Suzuki, Takeaki, Linda J. Paradiso, Jill Ricono, et al. "Abstract 5112: Evaluation of FF-10502-01, a new pyrimidine nucleoside analogue, in pancreatic (PANC) patient-derived xenograft (PDX) models compared to gemcitabine and in combination with nab-paclitaxel." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5112.

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