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Journal articles on the topic '5-(chloromethyl)-3-(4H-chromen-3-yl)-1'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Chunduru, Srinivasa Rao, Venkata Ramana Reddyy Ch., Jyotsna C., and S. Sait Shakil. "Synthesis of 3-[5-(morpholinomethyl/piperidinomethyl/pyrrolidinemethyl)-1 ,2 ,4- oxadiazol-3-yl]-4H-chromones." Journal of Indian Chemical Society Vol. 90, Sep 2013 (2013): 1461–66. https://doi.org/10.5281/zenodo.5790902.

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Department of Chemistry, JNTU, Kukatpally, Hyderabad-500 085, India Dr. Reddy Laboratories, Bachupally, Hyderabad-500 090, India <em>E-mail </em>: chemistrycsr@gmail.com <em>Manuscript received online 04 November 2012, revised 05 December 2012, accepted 30 December 2012</em> 5-(Chloromethyl)-3-(4<em>H</em>-chromen-3-yl)-1,2,4-oxadiazole (1a-e) react with pyrrolidine (6) to give 3-(4<em>H</em>-chromen-3-yl)-5-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazole (7a-e), (1a-e) react with piperidine (4) to give 1-{[3-(4<em>H</em>-chromen-3-yl)- 1,2,4-oxadiazol-5-yl]methyl}piperidine (5a-e) and (1a-e) react w

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2

Gašparová, Renata, Pavol Koiš, Margita Lácová, Silvia Kováčová, and Andrej Boháč. "Synthesis, reactions and antineoplastic activity of 3-(2-oxo-2H-chromen-3-yl)-2-oxo-2H,5H-pyrano[3,2-c]chromene derivatives." Open Chemistry 11, no. 4 (2013): 502–13. http://dx.doi.org/10.2478/s11532-012-0184-1.

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AbstractThe key 3-(2-oxo-2H-chromen-3-yl)-2-oxo-2H,5H-pyrano[3,2-c]chromen-5-yl acetates 3 were synthesized in high yields by cyclocondensation of 4-oxo-4H-chromen-3-carbaldehydes 1 with coumarin-3-acetic acids 2 under mild conditions. The reaction pathway involves aldol condensation and subsequent intramolecular lactonization to afford 2-oxo-2H,5H-pyrano[3,2-c]chromene skeleton 3. Further treatment of acetates 3 with alcohols, water or nitrogen containing compounds led to 5-alkoxy-, 5-hydroxy- or 5-acylamino-2H,5H-pyrano[3,2-c]chromen-2-ones 4-6 via nucleophilic substitution of acetyloxy grou

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3

Razgulyaev, Vladislav I., Polina A. Nikitina, Tatiana Yu Koldaeva, Vladimir S. Miroshnikov, and Valery P. Perevalov. "SYNTHESIS OF 2-(3-CHROMENYL)-4-ETHOXYCARBONYL-1-(4-FLUOROBENZYL)-5-METHYLIMIDAZOLE 3-OXIDES." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 2 (2017): 17. http://dx.doi.org/10.6060/tcct.2017602.5435.

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In addition to our search for probable HIV-1 integrase inhibitors in the series of imidazole derivatives a possibility of preparation of 2-(3-chromenyl)substituted imidazole 3-oxides containing fluorobenzyl moiety in position 1 of imidazole ring as a potential pharmacophore was demonstrated. 4-ethoxycarbonyl-1-(4-fluorobenzyl)-5-methyl-2-(4-oxo-4H-chromen-3-yl)imidazole 3-oxide 4a and 4-ethoxycarbonyl-2-(6-hydroxy-4-oxo-4H-chromen-3-yl)-1-(4-fluorobenzyl)-5-methyli-midazole 3-oxide 4b were synthesized starting with fluorobenzylamine 1, ethyl 2-(hydroxyimino)-3-oxobutanoate 2 and 4-oxo-4H-chrom

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Niranjan, M.S. *. and Chaluvaraju K.C. "SYNTHESIS AND CHARACTERIZATION OF TWO NOVEL THIOFIBRATES DERIVED FROM 7-HYDROXY-4-METHYL-2H CHROMEN-2-ONE." Journal of Pharma Research 7, no. 8 (2018): 190–93. https://doi.org/10.5281/zenodo.1345716.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>wo novel thiofibrates bearing 1,3,4-oxadizole and 1,2,4-triazole are prepared from 7-hydroxy-4-methyl-</em><em>2H-chromen-2-one (1). The compound (1) is obtained by treating resorcinol with ethyl acetate in the presence of concentrated sulphuric acid. It is then treated with ethylchloroacetate to get ethyl((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetate (2). This on hydrogenolysis gives 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (3) which on further reaction with phenyl isothiocyanate in presence of sodium hydroxide gives

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5

Tank, Manishkumar Jinabhai, Navinkumar A. Kucha, Chirag G. Naik, Tina R. Barot, and G. M. Malik. "Adamantane-pyrido[2,3-d]pyrimidine Derivatives; Synthesis, Characterization and Investigation of Antimicrobial Study." Oriental Journal Of Chemistry 39, no. 2 (2023): 393–402. http://dx.doi.org/10.13005/ojc/390219.

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Target molecules based on Adamantane-pyrido[2,3-d]pyrimidine derivatives were prepared. Adamantane-pyrido[2,3-d]pyrimidine series using N-(hydroxyadamantan-1-yl)-5-(2,4-substitutedphenyl)-2-Methyl-4-Oxo-7-(2-oxo-2H-Chromen-3-yl)pyrido[2,3-d]Pyrimidine-3(4H)carboxamide (6a-j) was synthesized by reaction between 3-(2-chloroacetyl)-5-(2,4-substitutedphenyl)-2-Methyl-7-(2-Oxo-2H-Chromen-3-yl) pyrido[2,3-d]pyrimidin-4(3H)-one (5a-j) and 3-aminoadamantan-1-ol. These derivatives of Adamantane-pyrido[2,3-d]Pyrimidine were investigated in vitro for their biological characteristics against the strains w

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Albuquerque, Hélio M. T., Diana C. G. A. Pinto, and Artur M. S. Silva. "Microwave Irradiation: Alternative Heating Process for the Synthesis of Biologically Applicable Chromones, Quinolones, and Their Precursors." Molecules 26, no. 20 (2021): 6293. http://dx.doi.org/10.3390/molecules26206293.

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Microwave irradiation has become a popular heating technique in organic synthesis, mainly due to its short reaction times, solventless reactions, and, sometimes, higher yields. Additionally, microwave irradiation lowers energy consumption and, consequently, is ideal for optimization processes. Moreover, there is evidence that microwave irradiation can improve the regioselectivity and stereoselectivity aspects of vital importance in synthesizing bioactive compounds. These crucial features of microwave irradiation contribute to its inclusion in green chemistry procedures. Since 2003, the use of

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Ramina, Rajkumar Bhubon Singh, and Oinam U-wang. "Synthesis, Characterization and DNA Binding Studies of Some Hydrazide Derivatives Schiff Base Metal Complexes of Mn(II), Co(II/III), Ni(II), Cu(II) and Zn(II) Metal Ions." Asian Journal of Chemistry 33, no. 12 (2021): 3006–24. http://dx.doi.org/10.14233/ajchem.2021.23408.

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Eighteen metal complexes were synthesized by using four different Schiff base ligands, (1E)-1-((6-methyl-4-oxo-4H-chromen-3-yl)methylene)carbohydrazide (L1), 6-[2-(salicylidene)hydrazinyl]-N′-(salicylidene)nicotinohydrazide (HL2), 6-hydrazinyl-N′-(6-methyl- 4-oxo-4H-chromen-3-yl-methylene)nicotinohydrazide (HL3) and (E)-6-hydrazinyl-N′-(1-(2,3-dihydro- 1,3-dioxo-1H-inden-2-yl)-ethylidene)pyridine-3-carbohydrazide (L4). Characterization of the metal complexes were carried out by using various physico-chemical techniques. Complexes 1, 3, 4, 6, 11, 14, 15, 16, 17 and 18 have been found octahedral

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Asyakina, Lyudmila, Stanislav Sukhikh, Svetlana Ivanova, et al. "Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea." Biomolecules 11, no. 3 (2021): 365. http://dx.doi.org/10.3390/biom11030365.

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The results of the qualitative composition analysis of the dried biomass extracts of in vitro callus, cell suspension, and root cultures show that the main biologically active substances (BAS) in the medicinal plant, Rhodiola rosea, are 6-C-(1-(4-hydroxyphenyl)ethyl)aromadendrin (25 mg, yield 0.21%), 2-(3,7-dihydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl)-6,7-dihydroxychroman-4-one (23 mg, yield 0.2%), 2-(3,4-dimethoxyphenyl)-5,7-dimethoxychroman-4-one (175 mg, yield 1.5%), 5,7-dihydroxy-2-(4-hydroxy-3-(2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl)phenyl)-4H-chromen-4-one (45 mg, yi

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Mohammadi-Khanaposhtani, Maryam, Kiana Fahimi, Elahe Karimpour-Razkenari, et al. "Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents." Letters in Drug Design & Discovery 16, no. 7 (2019): 818–24. http://dx.doi.org/10.2174/1570180815666180627121006.

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Background: This work reports design, synthesis, and in vitro cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids against three breast cancer cell lines MCF-7, MDA-MB-231, and T-47D. Methods: Synthetic procedure for the preparation of desired compounds was started from the reaction of coumarins or with propargyl bromide to give O-propargylated coumarins or 5. Then, click reaction between the later compounds and 3-aryl-5-(chloromethyl)-1,2,4-oxadiazoles afforded the desired products in good yields. Results: Among the synthesized compounds, 4-((1-((3-(4-chlorophenyl)-1,2,4-oxa

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Qureshi, Rahila. "Molecular docking analysis of an isoflavone derivative with the phosphatase 1 protein from Leishmania donovani." Bioinformation 16, no. 11 (2020): 942–48. http://dx.doi.org/10.6026/97320630016942.

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Leishmaniasis is one of the most neglected diseases with high morbidity and mortality rate. Severe side effects with existing drug and lack of proper vaccine encouraged us to design alternative models to combat the disease. We showed that PP1 of Leishmania donovani mediates immunomodulation in host macrophages needed for parasite survival. Therefore, it is of interest to report the molecular docking analysis of 512 isoflavone derivatives with the phosphatase 1 protein from Leishmania donovani to highlight compound 362 (5-hydroxy-5-{9-[2-methoxy-2-(2-methylfuran-3-yl) ethyl]-1H,3H,4H,10bH-pyran

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Shin, Soon Young, Miri Yoo, and Dongsoo Koh. "Crystal structure of 6-methoxy-3-(5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-4H-chromen-4-one-methanol (1/1), C20H18N2O6." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 5 (2020): 1253–55. http://dx.doi.org/10.1515/ncrs-2020-0298.

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AbstractC19H14N2O5 ⋅ CH3OH, monoclinic, P21/c (no. 14), a = 7.9074(3) Å, b = 20.4341(7) Å, c = 11.0406(4) Å, β = 92.6004(16)°, V = 1783.85(11) Å3, Z = 4, Rgt(F) = 0.0467, wRref(F2) = 0.1260, T = 223(2) K.

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Sriramoju, Shamili, Srinivas Avula, Sindhura Konda, and Kavitha Siddoju. "The development, preparation and characterisation of novel pyran derivatives and their biological assessment." Research Journal of Chemistry and Environment 28, no. 3 (2024): 61–69. http://dx.doi.org/10.25303/283rjce061069.

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We have synthesized some novel derivatives of 4-(1-(2, 4-dinitrophenyl)-3-phenyl-1H-pyrazol-4-yl)-7,7-dimet hyl-2-(methylamino)-3nitro-6,7,8,8a-tetrahydro-4H-chromen-5(4aH)-one by the multicomponent reaction of pyrazole aldehydes derivatives, N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) and 5,5-dimethylcyclohexane-1,3-dione. The synthesised compounds are confirmed by 1H NMR, IR and Mass Spectroscopy and they were then tested for antioxidant activities. In terms of antioxidant activity, compounds C-7 and C-1 were found to have the greatest and lowest levels respectively. Against Enterobacte

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Buddham, R., S. Yadav, P. Narad, D. Gupta, and P. Mathur. "Network based identification of Potential Key Genes associated with Alzheimer’s disease and Type 2 Diabetes using mTOR signalling." Research Journal of Biotechnology 17, no. 5 (2022): 38–50. http://dx.doi.org/10.25303/1705rjbt38050.

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mTOR is involved in various signalling pathways, including TSC1/TSC2/Rheb, PI3K/Akt, LKBL/AMPK, VAM6/Rag GTPase etc. and dysregulation of the mTOR pathway has been related with cancer, neurological diseases and type 2 diabetes. In the present work, we created a comprehensive network of mTOR signalling that consisted of 255 nodes (proteins/genes) and 592 edges (interactions) using the Cytoscape 3.6 editor and its plugins for analysis. The experimental design included retrieving gene expression profiles for two diseases, namely Alzheimer's disease (AD) and type 2 diabetes (T2D), from the Gene Ex

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Kumla, Decha, Tida Dethoup, Luís Gales, et al. "Erubescensoic Acid, a New Polyketide and a Xanthonopyrone SPF-3059-26 from the Culture of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA 0220 and Antibacterial Activity Evaluation of Some of Its Constituents." Molecules 24, no. 1 (2019): 208. http://dx.doi.org/10.3390/molecules24010208.

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A new polyketide erubescensoic acid (1), and the previously reported xanthonopyrone, SPF-3059-26 (2), were isolated from the uninvestigated fractions of the ethyl acetate crude extract of the marine sponge-associated fungus Penicillium erubescens KUFA0220. The structures of the new compound, erubescensoic acid (1), and the previously reported SPF-3059-26 (2), were elucidated by extensive analysis of 1D and 2D-NMR spectra as well as HRMS. The absolute configuration of the stereogenic carbon of erubescensoic acid (1) was determined by X-ray analysis. Erubescensoic acid (1) and SPF-3059-26 (2), t

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Liu, Xin-Hua, Jun Li, Fan-Rong Wu, Bao-An Song, Pinaki S. Bhadury, and Lei Shi. "Novel 3-(2-(3-methyl-5-substituted-phenyl-4,5-dihydropyrazol-1-yl)-2-oxoethoxy)-2-substituted-phenyl-4H-chromen-4-one: Synthesis and Anticancer Activity." Medicinal Chemistry 7, no. 6 (2011): 605–10. http://dx.doi.org/10.2174/157340611797928442.

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Jeong, Munki, Euitaek Jung, Young Han Lee та ін. "A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced MMP9 Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells". International Journal of Molecular Sciences 21, № 14 (2020): 5080. http://dx.doi.org/10.3390/ijms21145080.

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Breast cancer is a common malignancy among women worldwide. Gelatinases such as matrix metallopeptidase 2 (MMP2) and MMP9 play crucial roles in cancer cell migration, invasion, and metastasis. To develop a novel platform compound, we synthesized a flavonoid derivative, (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile (named DK4023) and characterized its inhibitory effects on the motility and MMP2 and MMP9 expression of highly metastatic MDA-MB-231 breast cancer cells. We found that DK4023 inhibited tumor necrosis factor alpha (TNFα)-induced motility and F-actin

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Lee, Jeong Yeon, Sung Shin Ahn, You Jeong Jeong, et al. "A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells." Journal of Chemistry 2020 (July 2, 2020): 1–11. http://dx.doi.org/10.1155/2020/3025281.

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Aurora kinases are Ser/Thr kinases that function as mitotic regulators. 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one (DK1913) is a synthetic pan-Aurora kinase inhibitor. However, the mode of action of DK1913 concerning the induction of apoptosis is unclear. Here, we report that DK1913 triggered apoptosis, as revealed by flow cytometry and Annexin V staining. DK1913 enhanced the intracellular levels of reactive oxygen species (ROS) and stimulated the endoplasmic reticulum (ER) and genotoxic stress responses. We also found that DK1913 induced the loss of mitochondrial membrane potenti

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Vinokur, Anastasiya I., Paul B. White, Maurice Tagatsing Fotsing, et al. "Deciphering composition and connectivity of a natural product with the assistance of MS and 2D NMR." Acta Crystallographica Section C Structural Chemistry 73, no. 11 (2017): 994–1002. http://dx.doi.org/10.1107/s2053229617014966.

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A complementary application of three analytical techniques, viz. multidimensional nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), and single-crystal X-ray diffractometry was required to identify and refine two natural products isolated from Millettia versicolor and solvent of crystallization. The two compounds, namely 3-(2H-1,3-benzodioxol-5-yl)-6-methoxy-8,8-dimethyl-4H,8H-pyrano[2,3-h]chromen-4-one, or durmillone, (I), and (2E)-1-(4-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one, (II), could not be separated by routine co

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Singh, Khumanthem Deepak, Dipak Chetia, and Biplab D. E. "NEW FLAVONOID COMPOUND FROM ALLIUM HOOKERI THWAITES AS A GASTROPROTECTIVE AGENT." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 5 (2018): 24. http://dx.doi.org/10.22159/ijpps.2018v10i5.24341.

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Objective: The main objective of this study was to investigate the antiulcer potential of an isolated flavonoid compound from Allium hookeri (AH).Methods: Oral administration of ethanol-induced ulcer to the mucosal layer of the stomach in the rats. The ulcer score and percentage protection was calculated from the stomach and gastric mucosal scrapping was carried out for the biochemical studies. Antioxidant study was carried out in liver and histopathological study of the ulcer stomach was performed.Results: Phytochemical investigation of methanolic extract of AH (MEAH) leaves afforded a new fl

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Vlasov, Sergiy V., Oleksandr V. Borysov, Hanna I. Severina, et al. "The synthesis, antimicrobial activity and docking studies of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin- 4(3H)-ones with acetamide and 1,2,4-oxadiazol-5-ylmethyl substituents." Journal of Organic and Pharmaceutical Chemistry 19, no. 3(75) (2021): 15–20. http://dx.doi.org/10.24959/ophcj.21.240775.

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Aim. To synthesize, study the antimicrobial activity and suggest antimicrobial activity mechanism for the novel derivatives of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one. Results and discussion. As the result of the targeted modification of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]-pyrimidin-4(3H)-one in position 3 with acetamide and 1,2,4-oxadiazol-5-ylmethyl substituents, the compounds, which demonstrated better antimicrobial activity in the agar well diffusion assay than the reference drug Streptomycin, were obtained. To elucidate the mechanism of action of the n

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Hong, Joo Young, Kyung-Sook Chung, Ji-Sun Shin, et al. "The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation." Cancers 11, no. 12 (2019): 1927. http://dx.doi.org/10.3390/cancers11121927.

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We previously reported the potential anti-proliferative activity of 3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)-N-(3,4,5-trimethoxyphenyl) benzamide (TMS-TMF-4f) against human cancer cells; however, the underlying molecular mechanisms have not been investigated. In the present study, TMS-TMF-4f showed the highest cytotoxicity in human cervical cancer cells (HeLa and CaSki) and low cytotoxicity in normal ovarian epithelial cells. Annexin V-FITC and propidium iodide (PI) double staining revealed that TMS-TMF-4f-induced cytotoxicity was caused by the induction of apoptosis in both HeLa and CaSki c

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Chang, Wei-Ting, and Sheng-Nan Wu. "Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels." Pharmaceuticals 14, no. 5 (2021): 388. http://dx.doi.org/10.3390/ph14050388.

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QO-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-7(4H)-one) is a novel and selective activator of KCNQ2/KCNQ3 K+ channels. However, it remains largely unknown whether this compound can modify any other type of plasmalemmal ionic channel. The effects of QO-40 on ion channels in pituitary GH3 lactotrophs were investigated in this study. QO-40 stimulated Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in these cells. QO-40-stimulated IK(Ca) was attenuated by the further addition of GAL-021 or paxilline but not by linopirdine or TRAM-34. In

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Shatokhin, S. S., V. A. Tuskaev, S. Ch Gagieva, D. I. Pozdnyakov, and E. T. Oganesyan. "SYNTHESIS AND ANTIOXIDANT ACTIVITY OF (E)-3-(3-(4-OXO-4H-CHROMEN-3-YL)ACRYLOYL) 2H-CHROMEN-2-ONE DERIVATIVES." Pharmacy & Pharmacology 9, no. 5 (2021): 367–76. http://dx.doi.org/10.19163/2307-9266-2021-9-5-367-376.

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The aim is based on the results of the in silico prediction, to obtain and characterize a number of (E)-3-(3-(4-oxo-4H-chromen-3-yl)acryloyl)-2H-chromen-2-one derivatives, and also to study their antioxidant activity.Materials and methods. The synthesis of the target compounds was carried out by condensation of substituted 3-formylchromones and 3-acetylcoumarins under the acid catalysis conditions. 1H NMR spectra were recorded on the instruments of Bruker Avance-400 (400 MHz) and Bruker Avance-300 (300 MHz) in the solutions of CDCl3 or DMSO-d6. Mass spectra (ESI) were obtained on a Finnigan LC

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Robertson, Mark J., André Horatscheck, Samantha Sauer, et al. "5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors." Organic & Biomolecular Chemistry 14, no. 47 (2016): 11266–78. http://dx.doi.org/10.1039/c6ob02308h.

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The development of a (Z)-5-((6,8-dichloro-4-oxo-4H-chromen-3-yl)methylene)-2-thioxothiazolidin-4-one (2), rhodanine-based lead that led to the Pitstop® 2 family of clathrin inhibitors is described herein.

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Ahn, Seunghyun, Yoongho Lim, and Dongsoo Koh. "Crystal structure of 2-(2,3-dimethoxynaphthalen-1-yl)-3-hydroxy-6-methoxy-4H-chromen-4-one." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): o842—o843. http://dx.doi.org/10.1107/s2056989015018861.

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In the title compound, C22H18O6, the dimethoxy-substituted naphthalene ring system is twisted relative to the 4H-chromenon skeleton by 88.96 (3)°. The two methoxy substituents are tilted from the naphthalene ring system by 1.4 (4) and 113.0 (2)°, respectively. An intramolecular O—H...O hydrogen bond closes anS(5) ring motif. In the crystal, pairs of O—H...O hydrogen bonds form inversion dimers withR22(10) loops and C—H...O interactions connect the dimers into [010] chains.

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Mohamed, Hany M., and Ashraf H. F. Abd El-Wahab. "Heteroaromatization with 4-Phenyldiazenyl-1-naphthol. Part IV: Synthesis of Some New Heterocyclic Compounds with Potential Biological Activity." Current Organic Synthesis 16, no. 6 (2019): 931–38. http://dx.doi.org/10.2174/1570179416666190719101727.

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Background: Synthetic azo compounds and their derivatives have been studied extensively due to their biological and pharmacological activities. Pyranopyridines, pyranopyrimidines and tetrazoles derivatives have emerged as a promising and attractive scaffold in the development of potent biological and pharmacological agents. Objectives: To design a series of new benzochromeno(pyridine/pyrimidine/tetrazole) derivatives and evaluate their antimicrobial activity against some bacterial strains (Gram-positive and Gram-negative) and some fungal strains. Materials and Methods: The (E)-7-(4-chloropheny

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Chen, Hai-Lin, Li-Wei Pan, Hui-Ying Zhang та Xiu-Ju Yin. "Synthesis and crystal structure of poly[aqua{μ3-(1S,2S)-1-((7-hydroxy-3-(4-hydroxy-3-sulfonatophenyl)-4-oxo-4H-chromen-8-yl)methyl)pyrrolidin-1-ium-2-carboxylato-κ4O,O′:O′′:O′′′}sodium(I)] monohydrate, C21H22NNaO11S". Zeitschrift für Kristallographie - New Crystal Structures 233, № 3 (2018): 469–71. http://dx.doi.org/10.1515/ncrs-2017-0360.

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Ananto, Agus Dwi, Harno Dwi Pranowo, Winarto Haryadi, and Niko Prasetyo. "Exploring The Inhibition of SARS-COV-2 PLpro: Docking and Molecular Dynamics Simulation of Flavonoid in Red Fruit Papua and Its Derivatives." Molekul 19, no. 3 (2024): 581. https://doi.org/10.20884/1.jm.2024.19.3.11717.

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In early 2024, Covid-19 witnessed a substantial decline in cases. Nevertheless, with lingering cases and fatalities persisting, it remains crucial to focus on research to develop patented medicines to inhibit the spread of this virus effectively. This study focuses on the Papain-like protease (PLpro) of SARS-CoV-2 because of its crucial role in the viral life cycle, where it is vital for processing precursor proteins into functional components required for viral replication and propagation. This study investigated the inhibitory potential of flavonoid compounds derived from red fruit (Pandanus

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Belal, Kamelia, A. H. El-Askalany, Eslam A. Ghaith, and Ahmed Fathi Salem Molouk. "Novel synthesized triazole derivatives as effective corrosion inhibitors for carbon steel in 1M HCl solution: experimental and computational studies." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-49468-5.

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AbstractThis article outlines the synthesis of two derivatives of 4-amino-5-hydrazineyl-4H-1,2,4-triazole-3-thiol for the prevention of carbon steel corrosion in 1M HCl solution. These derivatives are (Z)-3-(1-(2-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)hydrazono)ethyl)-2H-chromen-2-one (TZ1) and 5-(2-(9H-fluoren-9-ylidene)hydrazineyl)-4-amino-4H-1,2,4-triazole-3-thiol (TZ2). Weight loss, electrochemical experiments, surface examinations, and theoretical computation are used to evaluate the effectiveness of the two compounds to be used as corrosion inhibitors. Weight loss and electrochemical

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NGUYỄN VĂN SƠN, VÕ THÀNH CÔNG та PHẠM VĂN HƯNG. "TỔNG HỢP VÀ ĐÁNH GIÁ KHẢ NĂNG KHÁNG OXY HÓA CỦA DẪN XUẤT FLAVONOIDS MỚI TRÊN CƠ SỞ PHẢN ỨNG MANNICH". Journal of Science and Technology - IUH 62, № 02 (2023). http://dx.doi.org/10.46242/jstiuh.v62i02.4781.

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We successfully synthesized 4-(3,7-diacetoxy-5-hydroxy-4-oxo-4H-chromen-2-yl)-1,2-phenylene diacetate (1) from Quercetin with acetic anhydride. Based on the Mannich reaction of 1 with various amines and formaldehyde, six novel derivatives 2-7 were synthesized and formed at 80℃ for 1-3 hours with yields of about 65- 86%. The aminomethylation occurred preferentially in the position at C-6 of the A-ring of 1. All synthesized compounds were determined by molecular structure by modern physicochemical analysis methods such as FT-IR, 1H-NMR, 13C-NMR, and MS. Moreover, the synthesized compounds were e

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Halim, Shimaa Abdel, Hesham Hamad, and Tarik E. Ali. "Deeper insights into the density functional theory of structural, optical, and photoelectrical properties using 5-[(4-oxo-4H-chromen-3-yl) methylidene]-4-oxo (thioxo)-6-thioxo-2-sulfido-1, 3, 2-diazaphosphinanes." Optical and Quantum Electronics 55, no. 5 (2023). http://dx.doi.org/10.1007/s11082-023-04661-8.

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AbstractThe structure–activity relationship studied by DFT calculations and contacted with practical antimicrobial results for compounds 1–4 is discussed in detail. In light of this compounds 1–4 have been studied by using DFT/B3LYB/6-311++G (d,p) at the level of theory, the geometrical parameters, bond lengths and bond angles have been discussed. The results of quantum mechanical calculations showed that the presence of phosphorus and sulfur atoms changed the planarity of the parent compound 1 by the range from − 11 to 125°. The electronic parameter and dipole moment of these compounds in the

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Stalin, Antony, Paul Dhivya, Ding Lin, et al. "Synthesis, molecular docking and mosquitocidal efficacy of lawsone and its derivatives against the dengue vector Aedes aegypti L. (Diptera: Culicidae)." Medicinal Chemistry 17 (July 27, 2021). http://dx.doi.org/10.2174/1573406417666210727121654.

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Background: Aedes aegypti is the primary dengue vector, a significant public health problem in many countries. Controlling the growth of Ae. aegypti is the biggest challenge in the mosquito control program, and there is a need for finding bioactive molecules to control Ae. aegypti in order to prevent dengue virus transmission. Objective: To assess the mosquitocidal property of lawsone and its 3-methyl-4H-chromen-3-yl-1-phenylbenzo[6,7]chromeno[2,3,c]pyrazole-dione derivatives (6a-6h) against various life stages of Ae. aegypti. Besides, to study the mode of action of the active compound by mole

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