Academic literature on the topic '629.735.017 (043.2)'

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Journal articles on the topic "629.735.017 (043.2)"

1

Dunlop, Hayley, Evelyn Fitzpatrick, Kevin Kurti, et al. "Participation of Patients From Racial and Ethnic Minority Groups in Phase 1 Early Cancer Drug Development Trials in the US, 2000-2018." JAMA Network Open 5, no. 11 (2022): e2239884. http://dx.doi.org/10.1001/jamanetworkopen.2022.39884.

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ImportanceDespite federal initiatives encouraging the enrollment of individuals from racial and ethnic minority groups in US clinical trials, no studies to date have specifically examined demographic disparities among participants in phase 1 drug development trials for patients with metastatic cancer.ObjectiveTo assess trends in the enrollment of patients from racial and ethnic minority groups in US phase 1 therapeutic drug trials for metastatic cancer from 2000 to 2018.Design, Setting, and ParticipantsIn this cross-sectional study, ClinicalTrials.gov was queried in July 2021 to identify compl
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2

Moore, Beverley A., Kathryn M. Albers, Brian M. Davis, Jennifer R. Grandis, Sandra Tögel, and Anthony J. Bauer. "Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age." American Journal of Physiology-Gastrointestinal and Liver Physiology 292, no. 6 (2007): G1650—G1659. http://dx.doi.org/10.1152/ajpgi.00570.2006.

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Susceptibility to postoperative ileus following abdominal surgery increases with advancing age. The mechanisms underlying this phenomenon are unknown. This study compares functional and molecular endpoints between young-adult (2 mo old), middle-aged (15 mo old), and elderly mice (26–30 mo old) to identify potential mechanisms. Susceptibility to ileus was assessed by measuring gastrointestinal transit (geometric center) 24 h after anesthesia, laparotomy, and light manipulation (LM) of the small bowel. Proinflammatory (IL-6, COX-2, inducible nitric oxide synthase) and anti-inflammatory (IL-10, h
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Krzywicka, Katarzyna, Anita van de Munckhof, Mayte Sánchez van Kammen, et al. "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination." Neurology 98, no. 7 (2021): e759-e768. http://dx.doi.org/10.1212/wnl.0000000000013148.

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Background and ObjectivesCerebral venous sinus thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.MethodsWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of a first dose of 4 SARS-CoV-2 vaccinations using data from the Europea
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Bruni, C., M. Occhipinti, G. Camiciottoli, et al. "OP0181 FUNCTIONAL CUT-OFFS TO DISTINGUISH PULMONARY VASCULAR AND PARENCHYMAL INVOLVEMENT IN SYSTEMIC SCLEROSIS (SSC): A QUANTITATIVE ANALYSIS OF IMAGING FEATURES AT CHEST COMPUTED TOMOGRAPHY (CT)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 112.1–113. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2188.

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Background:Interstitial lung disease (ILD) and pulmonary arterial hypertension represent the most frequent causes of morbidity and mortality in SSc, with chest CT representing the gold standard in ILD assessment, while FVC and DLco allow functional assessment.Objectives:As qualitative analysis of given chest CT scans is hampered by low reproducibility, we aimed to perform a quantitative analysis (QA) of CT scans able to investigate the parenchymal and vascular features in SSc-ILD and thus testing the relationship with clinical-functional data.Methods:We prospectively enrolled 80 patients who u
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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics
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Kim, Choo-Won, Alla Godelman, Vineet R. Jain, Avraham Merav, and Linda B. Haramati. "Postlobectomy Chest Radiographic Changes: A Quantitative Analysis." Canadian Association of Radiologists Journal 62, no. 4 (2011): 280–87. http://dx.doi.org/10.1016/j.carj.2010.12.005.

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Purpose To provide a quantative analysis of postlobectomy chest radiographic changes and to evaluate whether the scarring from prior sternotomy affects the size of the hemithorax and the duration of air leak in patients with subsequent lobectomy. Methods In this retrospective case-controlled series, 10 consecutive patients who had a lobectomy after a prior sternotomy and 30 controls, 3 for each case, matched for lobectomy site were identified. Pre- and postoperative chest radiographs were quantitatively analysed for diaphragmic elevation, size of each hemithorax, mediastinal shift, and the pre
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7

Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis
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Pérez-Stable, Eliseo J., Asmi Panigrahi, Saida I. Coreas, et al. "Diabetes and Hypertension Risk Across Acculturation and Education Levels in Hispanic/Latino Adults." JAMA Health Forum 6, no. 3 (2025): e250273. https://doi.org/10.1001/jamahealthforum.2025.0273.

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ImportanceAcculturation among Hispanic/Latino populations, defined as adaptation to US lifestyle and culture, is often assumed to lead to adverse health outcomes that will reduce the immigrant health advantage.ObjectiveTo evaluate the risks for incident diabetes and hypertension by levels of acculturation and educational attainment.Design, Setting, and ParticipantsThis study used data from the Hispanic Community Health Study/Study of Latinos, a population-based cohort study of men and women aged 18 to 74 years who identified as Central American, Cuban, Dominican, Mexican, Puerto Rican, or Sout
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Qin, Shukui, Zhiguo Hou, Chi Ma, Fangzhou Xia, Ni Guan, and Yuting Chen. "Comprehensive analysis on reactive cutaneous capillary endothelial proliferation following camrelizumab-based therapy in patients with solid tumors: A large-scale pooled analysis of nine phase 2 or phase 3 registration trials." Journal of Clinical Oncology 43, no. 16_suppl (2025): 11037. https://doi.org/10.1200/jco.2025.43.16_suppl.11037.

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11037 Background: Previous studies demonstrated the positive association between cutaneous immune-related adverse events and long-term survival in advanced cancer patients treated with immunotherapy. As a unique adverse event related to camrelizumab, the association of reactive cutaneous capillary endothelial proliferation (RCCEP) with patient prognosis may also exist. Here we comprehensively analyzed the characteristics of RCCEP and this association. Methods: This was a pooled analysis based on individual patient-level data derived from seven phase 3 and two phase 2 registration trials for ne
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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.

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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term antico
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