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Journal articles on the topic "658.8 : 339.166.5"

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Dale, David C., Steven P. Treon, David F. McDermott, et al. "Oral Administration of Mavorixafor, a CXCR4 Antagonist, Increases Peripheral White Blood Cell Counts across Different Disease States." Blood 138, Supplement 1 (2021): 2186. http://dx.doi.org/10.1182/blood-2021-152990.

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Abstract Introduction: Peripheral leukocyte deficiency is a common feature of multiple diseases and may render affected individuals susceptible to infections, both common and opportunistic. The CXCR4 chemokine receptor regulates the trafficking of leukocytes among the bone marrow, blood, and lymphatic system (Al Ustwani O, et al. Br J Haematol. 2014;164:15-23). Mavorixafor is an orally available investigational, small-molecule, selective antagonist of the CXCR4 receptor with potential to restore physiological trafficking and maturation of white blood cells (WBCs). Mavorixafor was previously sh
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Žorža, Laura, Aija Dēliņa, Tūrs Selga, and Olga Muter. "Characterization of Biofilm Formation and Bacterial Resistance to Benzalkonium Chloride under Contrasting Cultivation Conditions." Fermentation 9, no. 8 (2023): 699. http://dx.doi.org/10.3390/fermentation9080699.

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Benzalkonium chloride (BAC) is one of the most commonly used quaternary ammonium compounds in the pharmaceutical, cosmetic, and food industries. The aim of our study was to compare the physiological responses of Escherichia coli MSCL 332, Pseudomonas putida MCCL 650, and Staphylococcus epidermidis MSCL 333 on 50 mg/L BAC in rich and poor medium (100% and 5% tryptone soya broth (TSB)) in the temperature range from 8 °C to 37 °C, under static and shaking conditions. A high-throughput, 96-well microplate method was used to compare a broad range of cultivation conditions. The effect of BAC on grow
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Kang, Elizabeth M., Ellen M. Areman, Virginia David-Ocampo, et al. "Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait." Blood 99, no. 3 (2002): 850–55. http://dx.doi.org/10.1182/blood.v99.3.850.

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Abstract Mobilized peripheral blood is increasingly used as the source of hematopoietic stem cells for allogeneic transplantation, currently the only curative approach for sickle cell anemia. However, the safety and feasibility of stem cell mobilization in individuals with sickle cell trait (SCT) has not been documented. This study is a prospective controlled trial to evaluate the safety and feasibility of peripheral blood stem cell (PBSC) mobilization in 8 SCT subjects and 8 control subjects matched for age and race. Mobilization with filgrastim 10 μg/kg subcutaneous daily for 5 days was foll
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4

Khadidja KERZABI-KANOUN, Nabila BELYAGOUBI-BENHAMMOU, Larbi BELYAGOUBI, et al. "Antioxidant Activity of Brown Seaweed (Padina pavonica (L.) Extracts From the Algerian Mediterranean Coast." Journal of Natural Product Research and Applications 1, no. 02 (2021): 54–62. http://dx.doi.org/10.46325/jnpra.v1i02.15.

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The crude methanolic extract, ethyl acetate and butanolic fractions, tannins, saponins and polysaccharides of the marine brown alga, Padina pavonica, growing on the Algerian Mediterranean Coast were measured for antioxidant activity, using total antioxidant capacity (TAC), reducing power and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Total phenolic, flavonoid and proanthocyanidin contents were determined. The total phenolic, proanthocyanidin and flavonoid contents of methanolic extract were about of 2.007 ± 0.104 mg GAE/g DM, 4.611 ± 0.346 mg CE/g DM and 1.132 ± 0.091 mg C
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Lazo-Langner, Alejandro, Jeff Hawell, Michael J. Kovacs, et al. "A Systematic Review and Meta-Analysis of Proportions of Thrombosis and Bleeding in Patients Receiving Venous Thromboembolism (VTE) Prophylaxis After Orthopedic Surgery (OS). An Update." Blood 114, no. 22 (2009): 3125. http://dx.doi.org/10.1182/blood.v114.22.3125.3125.

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Abstract Abstract 3125 Poster Board III-62 VTE is the most frequent complication of OS and it can be prevented through anticoagulant prophylaxis. Numerous studies have evaluated different agents for this purpose and there are new agents currently under development or recently approved for this indication. We conducted a systematic review of randomized controlled trials (RCT) evaluating administration of anticoagulants for VTE prophylaxis in OS and performed a MA of proportions to estimate the overall incidence of major VTE (proximal VTE, pulmonary embolism (PE), or death from PE), total VTE (p
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6

Varghese, Abraham Mullasseril, Lauren Wright, Talha Munir, Russell Patmore, Catherine Parbutt, and Alexandra Smith. "Population-Based Registry Data over 15 Years Suggests Comparable Overall Survival for CLL Patients Treated with Chemoimmunotherapy and Targeted Therapies As First-Line Treatments." Blood 144, Supplement 1 (2024): 5122. https://doi.org/10.1182/blood-2024-201655.

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Phase 3 clinical trials have shown that targeted therapies (TT), significantly improve progression-free survival (PFS) compared to chemoimmunotherapy (CIT) for patients with chronic lymphocytic leukemia (CLL) with very few demonstrating a difference in overall survival (OS). TT are now the preferred first-line treatment for CLL patients across all age groups. Nevertheless, evidence demonstrating differences in OS in real-world settings remains scarce. This study aims to evaluate OS in patients who began treatment with either chemotherapy (CT) or CIT compared to those who received TT as their f
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Gomes, Tiago Halyson de Oliveira, Welleson Feitosa Gazel, Emanuela Ferreira Goulart, Jennifer Lee Gonçalves, Gabriel Vargas Maia Chaves, and Lígia Luana Freire da Silva. "ÓBITOS DEVIDOS À SEPSE ESTREPTOCÓCICA NO BRASIL: ANÁLISE DE 13 ANOS." Revista ft 29, no. 143 (2025): 45–46. https://doi.org/10.69849/revistaft/ch10202502210945.

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Introdução: A sepse é uma síndrome caracterizada por uma resposta inflamatória exacerbada a uma infecção, levando à disfunção orgânica e risco elevado de morte. Fatores de risco como o uso de cateteres, sonda uretral, imunossupressão, comorbidades, infecções pré-existentes, resistência antimicrobiana e estado nutricional comprometido são determinantes importantes para o desenvolvimento da doença. Objetivos: O objetivo do presente trabalho é realizar o levantamento epidemiológico acerca dos óbitos por casos de septicemia estreptocócica no Brasil, em um período de 13 anos. Bem como realizar o le
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Maseeh, Arun, Bhawana Awasthy, and Somrita Modak. "Anticancer–drug-induced interstitial lung disease (DIILD): With great power comes great responsibility." Journal of Clinical Oncology 41, no. 16_suppl (2023): e18699-e18699. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18699.

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e18699 Background: DIILD accounts for 3-5% of all ILD cases, with Anticancer agents accounting for 23-51% of all cases, and Case-Fatality Rates of 51.3%. Guidelines for anticancer therapy-related DIILD are lacking. DIILD was not often identified as an adverse event until late in drug development or after launch. Methods: Publications till Feb 2023 were reviewed for incidence, time to onset, prevention and early identification of anticancer DIILD. Results: Highest reportedincidence of DIILD was associated with targeted therapies [mTOR Inhibitors (9.5- 58%), Anti-EGFR (0.9 - 5.9%), MEK inhibitor
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Gordon, Kenneth, Diamant Thaçi, Melinda Gooderham, et al. "Bimekizumab Safety and Tolerability in Moderate to Severe Plaque Psoriasis: Pooled Analysis from Up to 4 Years of Treatment in 5 Phase 3/3b Clinical Trials." SKIN The Journal of Cutaneous Medicine 8, no. 4 (2024): s404. http://dx.doi.org/10.25251/skin.8.supp.404.

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Introduction: Psoriasis is a chronic condition requiring long-term management; evaluating long-term safety of treatments is important. We report the first 4-year (yr) safety data for bimekizumab (BKZ) in patients with moderate to severe plaque psoriasis. Methods: Data were pooled from 5 trials: BE SURE/BE VIVID/BE READY, their open-label extension (OLE) BE BRIGHT (4‑yr data; cut-off 14Nov2022), and BE RADIANT (3‑yr data; cut‑off 6May2022).1-5 Patients received BKZ 320mg every 4 weeks (wks)(Q4W) or Q8W; all received Q8W from Wk64 (BE RADIANT)/OLE Wk48 (BE BRIGHT) or next scheduled visit. Treatm
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Prieto-Peña, D., F. Genre, S. Remuzgo Martinez, et al. "AB0146 BAFF, APRIL y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IgA VASCULITIS AND IgA NEPHROPATHY?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1203–4. http://dx.doi.org/10.1136/annrheumdis-2022-eular.425.

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BackgroundIgA vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions [1, 2], that share pathogenic mechanisms [1], in which B-lymphocytes are described as key cells implicated in these processes. BAFF, APRIL and BAFF-R are cytokines implicated in the development of B-lymphocytes [3, 4] and in autoimmune processes [5, 6]. In this regard, an influence of BAFF, APRIL and BAFFR polymorphisms was observed on several immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion variant for inflammatory conditions [7, 8].ObjectivesTo determine whether BAFF, APRIL and
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Reports on the topic "658.8 : 339.166.5"

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Wersal, Ryan, Bradley Sartain, Kurt Getsinger, et al. Improving chemical control of nonnative aquatic plants in run-of-the-river reservoirs. Engineer Research and Development Center (U.S.), 2024. http://dx.doi.org/10.21079/11681/48350.

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Current dam discharge patterns in Noxon Rapids Reservoir reduce concentration and exposure times (CET) of herbicides used for aquatic plant management. Herbicide applications during periods of low dam discharge may increase herbicide CETs and improve efficacy. Applications of rhodamine WT dye were monitored under peak (736 to 765 m³ s⁻¹) and minimum (1.4 to 2.8 m³ s⁻¹) dam discharge patterns to quantify water-exchange processes. Whole-plot dye half-life under minimal discharge was 33 h, a 15-fold increase compared with the dye treatment during peak discharge. Triclopyr concentrations measured
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Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich, and David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.

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The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This ric
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