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Journal articles on the topic '9 acridinyl amino acid derivatives'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Rupar, Jelena, Vladimir Dobričić, Jelena Grahovac, et al. "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives." RSC Med Chem 11, no. 3 (2020): 378–86. https://doi.org/10.1039/c9md00597h.

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A series of eleven 9-acridinyl amino acid derivatives were synthesized using a two-step procedure. Cytotoxicity was tested on the K562 and A549 cancer cell lines and normal diploid cell line MRC5 using the MTT assay. Compounds 6, 7, 8 and 9 were the most active, with IC50 values comparable to or lower than that of chemotherapeutic agent amsacrine. 8 and 9 were especially effective in the A549 cell line (IC50 ≈ 6 μM), which is of special interest since amsacrine is not sufficiently active in lung cancer patients. Cell cycle analysis revealed that 7 and 9 caused G2/M block, amsacrine ca

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2

Zlatković, Đorđe, Vladimir Dobričić, Jelena Srbljanović, et al. "N-(9-Acridinyl) Amino Acid Derivatives: Synthesis and In Vitro Evaluation of Anti-Toxoplasma gondii Activity." Pharmaceutics 17, no. 3 (2025): 374. https://doi.org/10.3390/pharmaceutics17030374.

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Background/Objectives: Acridine, an aromatic heterocyclic compound, serves as a basis for the synthesis of potent bioactive derivatives, displaying a broad spectrum of biological activity, such as antibacterial, antitumor, and antiparasitic activity. With the ability to undergo various types of electrophilic substitutions, introducing different side chains could lead to compounds being active towards various and potentially multiple biotargets. Toxoplasma gondii, a ubiquitous protozoan parasite with worldwide distribution, poses a major health threat, particularly in immunocompromised patients

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3

Rupar, Jelena, Vladimir Dobričić, Jelena Grahovac, et al. "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives." RSC Medicinal Chemistry 11, no. 3 (2020): 378–86. http://dx.doi.org/10.1039/c9md00597h.

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4

Chiu, FCK, RTC Brownlee та DR Phillips. "Cupric Ion Chelation Assisted Synthesis of N(α)-Protected N(ω)-Acridin-9-yl α,ω-Diamino Carboxylic Acids". Australian Journal of Chemistry 46, № 8 (1993): 1207. http://dx.doi.org/10.1071/ch9931207.

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The synthesis of Nα-protected Nω-acridin-9-yl derivatives of the α,w-diamino carboxylic acids ornithine and lysine is reported. Direct introduction of the acridin-9-yl moiety to the amino side chain of the free amino acid was achieved in methanol through temporary copper(II) chelation protection of the α-amino and carboxy groups. Nα-Fmoc protection was introduced by using N-(fluoren-9-ylmethoxycarbonyloxy)succinimide in aqueous dioxan.

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5

Janovec, Ladislav, Gejza Suchár, Ján Imrich, et al. "9-Isothiocyanatoanthracene as a Versatile Starting Compound in the Chemistry of Anthracen-9-yl Derivatives." Collection of Czechoslovak Chemical Communications 67, no. 5 (2002): 665–78. http://dx.doi.org/10.1135/cccc20020665.

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The synthesis, structure and reactivity of 9-isothiocyanatoanthracene (5) likewise the conformation of the corresponding thioureas (6a-6i) have been studied. The 13C NMR substituent chemical shift values of the NCS group and correlations between spectral parameters (IR, NMR) and rate constans of reactions of 5, acridin-9-yl (14), phenyl (15) and benzoyl isothiocyanate (16) with butylamine were found. Significant increase of the fluorescence of the synthesized anthracenylthioureas with amino acid rests refers to the possibility to use 5 as potential biomarker.

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6

Smetanin, Nikolay, Sofia Tokarieva, Svetlana Varenichenko, Oleg Farat, and Victor Markov. "IN SILICO PREDICTION AND MOLECULAR DOCKING STUDIES OF BIOLOGICAL ACTIVITY OF HYDROACRIDINE (QUINOLINE) DERIVATIVES." Ukrainian Chemistry Journal 87, no. 5 (2021): 38–52. http://dx.doi.org/10.33609/2708-129x.87.05.2021.38-52.

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To find biological activity among easily available 2-[(4S,4’S/4R,4’R)-2’,5’-dioxo-2,3,5,6,7,8-hexahydro-1H-spiro[acridine-4,3’-pyrrolidin]-4’-yl]-N-aryl-acetamide, (4S/4R)-4-[(3R/3S)-1-(2-aryl)-2,5-dioxopyrrolidin-3-yl]-1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile, (3S/4R)-3-[(3R/4S)-9-chloroacridine(quinoline)-4-yl]-1-N-aryl)pyrrolidine-2,5-diones. Methods: Organic synthesis, spectral methods, and molecular docking. We investigated by molecular docking the potential biological activity of previously synthesized compounds containing acridine and pyrrolidine-2,5-diones fragments in their st

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7

Matarazzo, Augusto, Mohamed E. Moustafa, and Robert H. E. Hudson. "5-(Acridin-9-ylamino)uracil — A hydrolytically labile nucleobase modification in peptide nucleic acid." Canadian Journal of Chemistry 91, no. 12 (2013): 1202–6. http://dx.doi.org/10.1139/cjc-2013-0288.

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5-Aminouracil (5-AU) is a readily available yet underutilized starting material for the synthesis of labelled nucleobase analogues. We have prepared the derivative of 5-AU with the amine-reactive chromophore 9-chloroacridine for the purpose of investigating its potential as a base-discriminating fluorophore. 9-Chloroacridine readily undergoes substitution by reaction with 5-AU to yield a fluorescent nucleobase that after standard manipulations produced a monomer suitable for incorporation into peptide nucleic acid (PNA) by fluorenylmethyloxycarbonyl (Fmoc)-based oligomerization chemistry. Alth

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8

Kimura, Michio. "Acridine Derivatives. I. Molecular Structure of the Novel Acridinyl-Substituted Uracil, 5-(9-Acridinyl)-6-amino-1,3-dimethyluracil." Bulletin of the Chemical Society of Japan 60, no. 2 (1987): 447–51. http://dx.doi.org/10.1246/bcsj.60.447.

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9

RAGAB, A. EL-SAYED. "Some Novel Organosulfur Amino Acid Derivatives." Journal of Indian Chemical Society Vol. 75, May 1998 (1998): 323–24. https://doi.org/10.5281/zenodo.5945267.

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Chemistry Department. Faculty of Science, Al-Azhar University, Nasr City,Cairo, Egypt <em>Manuscript received 14 February 1997, accepted 8 September 1997</em> Synthesis of a series of 4-chlorocinnamanilide-4'-sulfonylamino acids (2-8), and some of the corresponding amino acid methyl esters (9-13) and hydrazides (14-16) are described. Coupling reactions of 4-chlorocinnamanilidc-4'-sulfonylamino acids with amino acid methyl ester hydrochloride in <strong>THF-Et<sub>3</sub>N</strong> medium using dicyclohexylcarbidiimide method give the dipeptide methyl esters (17-19).

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10

Moustafa, Moustafa Sherief, Saleh Mohammed Al-Mousawi, Maghraby Ali Selim, Ahmed Mohamed Mosallam, and Mohamed Hilmy Elnagdi. "Organobase-catalyzed three-component reactions for the synthesis of 4H-2-aminopyrans, condensed pyrans and polysubstituted benzenes." Beilstein Journal of Organic Chemistry 10 (January 14, 2014): 141–49. http://dx.doi.org/10.3762/bjoc.10.11.

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Novel routes for the preparation of 2-amino-4H-pyran-3-carbonitrile 9, amino-arylbenzoic acid ester derivatives 13a,b, 2-aminotetrahydro-4H-chromene-3-carbonitrile 18, 3-amino-4-cyanotetrahydronaphthalene-2-carboxylic acid ester 26 and 4-amino-3,5-dicyanophthalic acid ester derivatives 37a–c were developed. The synthetic methods utilize one-pot reactions of acetylene carboxylic acid esters, α,β-unsaturated nitriles and/or active methylenenitriles in the presence of L-proline or DABCO. Plausible mechanisms are suggested for the formation of the products. Finally, these compounds were used for t

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11

Zhang, Xu, Bing Han, Zi-Ming Feng, Ya-Nan Yang, Jian-Shuang Jiang, and Pei-Cheng Zhang. "Novel phenylpropanoid–amino acid adducts fromLigusticum chuanxiong." Organic Chemistry Frontiers 5, no. 9 (2018): 1423–30. http://dx.doi.org/10.1039/c8qo00012c.

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12

Shao, Hui, Xiaohui Jiang, Peter Gantzel, and Murray Goodman. "Tilted amides in amino acid and peptide derivatives." Chemistry & Biology 1, no. 4 (1994): 231–34. http://dx.doi.org/10.1016/1074-5521(94)90015-9.

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13

Troin, Yves, Christelle Lamazzi, Sylvie Carbonnel, and Pierre Calinaud. "Synthesis of 4-Substituted Indolizidin-9-one Amino Acid Derivatives." HETEROCYCLES 60, no. 6 (2003): 1447. http://dx.doi.org/10.3987/com-03-9757.

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14

Ankner, Tobias, Thomas Norberg, and Jan Kihlberg. "Mild Oxidative Cleavage of 9-BBN-Protected Amino Acid Derivatives." European Journal of Organic Chemistry 2015, no. 17 (2015): 3767–70. http://dx.doi.org/10.1002/ejoc.201500361.

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15

Xu, Mei-Li, and Wenhua Huang. "Syntheses of 9-Triptycylisothiocyanate, (10-Amino-9-triptycyl)carboxylic Acid, and Their Derivatives." Synthetic Communications 44, no. 23 (2014): 3435–40. http://dx.doi.org/10.1080/00397911.2014.944621.

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16

Burgess, VA, та CJ Easton. "Reaction of N-Benzoyl-2-bromoglycine Methyl Ester With Deprotonated Nitroalkanes: Synthesis of β-Nitro and α,β-Dehydro Amino Acid Derivatives". Australian Journal of Chemistry 41, № 7 (1988): 1063. http://dx.doi.org/10.1071/ch9881063.

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N-Benzoyl-2-bromoglycine methyl ester (1) reacted with the alkyl nitronates (2a-e) to give the corresponding β-nitro amino acid derivatives (4a-e). Elimination reactions of (4a-d) afforded the α,β-dehydro amino acid derivatives (5a-d). Treatment of the β- nitrovaline derivative (4b) with tributyltin hydride gave the valine derivative (8). Reduction of the β- nitroalanine derivative (4a) gave the β- aminoalanine derivative (9), characterized by hydrolysis to 2,3- diaminopropionic acid hydrochloride.

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17

Ravikumar, Krishnan, Balasubramanian Sridhar, Jagadeesh Babu Nanubolu, Tamilselvan Rajasekaran та Basi Venkata Subba Reddy. "Four oxoindole-linked α-alkoxy-β-amino acid derivatives". Acta Crystallographica Section C Structural Chemistry 71, № 4 (2015): 322–29. http://dx.doi.org/10.1107/s2053229615005604.

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Four structures of oxoindolyl α-hydroxy-β-amino acid derivatives, namely, methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-methoxy-2-phenylacetate, C24H28N2O6, (I), methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-ethoxy-2-phenylacetate, C25H30N2O6, (II), methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-[(4-methoxybenzyl)oxy]-2-phenylacetate, C31H34N2O7, (III), and methyl 2-[(anthracen-9-yl)methoxy]-2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-phenylacetate, C38H36N2O6, (IV), have been determined. The diastere

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18

Al-Masoudi, Najim A., Einas Abood, Ziyad T. Al-Maliki, Wasfi A. Al-Masoudi та Christophe Pannecouque. "Amino acid derivatives. Part 6. Synthesis, in vitro antiviral activity and molecular docking study of new N-α-amino acid derivatives conjugated spacer phthalimide backbone". Medicinal Chemistry Research 25, № 11 (2016): 2578–88. http://dx.doi.org/10.1007/s00044-016-1693-9.

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19

Liu, Chi, Xinyue Liu, Qing Ma, Fengyan Su, and Enbo Cai. "Design, Synthesis, and Antitumor Activity of Isoliquiritigenin Amino Acid Ester Derivatives." Molecules 29, no. 11 (2024): 2641. http://dx.doi.org/10.3390/molecules29112641.

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Isoliquiritigenin (ISL) is a chalcone that has shown great potential in the treatment of cancer. However, its relatively weak activity and low water solubility limit its clinical application. In this study, we designed and synthesized 21 amino acid ester derivatives of ISL and characterized the compounds using 1H NMR and 13C NMR. Among them, compound 9 (IC50 = 14.36 μM) had a better inhibitory effect on human cervical cancer (Hela) than ISL (IC50 = 126.5 μM), and it was superior to the positive drug 5-FU (IC50 = 33.59 μM). The mechanism of the action experiment showed that compound 9 could ind

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20

Fornicola, Richard S., and John Montgomery. "Convenient preparation of amino acid derivatives with two 13C labels." Tetrahedron Letters 40, no. 48 (1999): 8337–41. http://dx.doi.org/10.1016/s0040-4039(99)01783-9.

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21

Polat, İlknur, Selçuk Eşsiz, Uğur Bozkaya, and Emine Salamci. "Efficient and regioselective synthesis of dihydroxy-substituted 2-aminocyclooctane-1-carboxylic acid and its bicyclic derivatives." Beilstein Journal of Organic Chemistry 18 (January 6, 2022): 77–85. http://dx.doi.org/10.3762/bjoc.18.7.

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The first synthesis of 2-amino-3,4-dihydroxycyclooctane-1-carboxylic acid, methyl 6-hydroxy-9-oxo-8-oxabicyclo[5.2.1]decan-10-yl)carbamate, and 10-amino-6-hydroxy-8-oxabicyclo[5.2.1]decan-9-one starting from cis-9-azabicyclo[6.2.0]dec-6-en-10-one is described. cis-9-Azabicyclo[6.2.0]dec-6-en-10-one was transformed into the corresponding amino ester and its protected amine. Oxidation of the double bond in the N-Boc-protected methyl 2-aminocyclooct-3-ene-1-carboxylate then delivered the targeted amino acid and its derivatives. Density-functional theory (DFT) computations were used to explain the

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22

Schäfer, Sibylle, Stefan Schwaiger, and Hermann Stuppner. "Aristolic Acid Derivatives from the Bark of Antidesma ghaesembilla." Planta Medica 83, no. 12/13 (2017): 1097–102. http://dx.doi.org/10.1055/s-0043-110141.

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Abstract Antidesma ghaesembilla is an important medicinal and food plant in many Asian countries. Ten substances could be isolated from the dichloromethane and methanol extract: sitostenone (3), daucosterol (4), chavibetol (5), asperphenamate (6), protocatechuic acid (7), vanillic acid-4-O-β-D-glucoside (8), 1-O-β-D-glucopyranosyl-3-O-methyl-phloroglucinol (9), and aristolic acid II-8-O-β-D-glucoside (10), and two new aristolic acid derivatives, 10-amino-5,7-dimethoxy-aristolic acid II (= 6-amino-9,11-dimethoxyphenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid; 1) and 5,7-dimethoxy-aristolochic a

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23

Ankner, Tobias, Thomas Norberg, and Jan Kihlberg. "ChemInform Abstract: Mild Oxidative Cleavage of 9-BBN-Protected Amino Acid Derivatives." ChemInform 46, no. 44 (2015): no. http://dx.doi.org/10.1002/chin.201544214.

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24

Podhradský, Dušan, Peter Oravec, Marián Antalík, and Pavol Kristian. "Fluorescence Reagents for Labelling of Biomolecules. Part II. Reactions of 9-Isothiocyanatoacridine with Amino Acids." Collection of Czechoslovak Chemical Communications 59, no. 1 (1994): 213–21. http://dx.doi.org/10.1135/cccc19940213.

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N-(9-Acridinylthiocarbamoyl)amino acids (ATC-AA) II - VII were synthesized by reaction of amino acids with 9-isothiocyanatoacridine I, a new fluorescence labelling agent. The amino acid derivatives II - VII show high relative fluorescence, which is suitable for the determination of nanomolar amounts of ATC-AA. The kinetic measurements show that reaction of I with amino acids is 6 to 22 times faster than analogous reaction of phenyl isothiocyanate. The possibility of using 9-isothiocyanatoacridine for structure determination of proteins is discussed.

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25

Yamagishi, Takehiro, Kenji Suemune, Tsutomu Yokomatsu та Shiroshi Shibuya. "Asymmetric synthesis of β-amino-α-hydroxyphosphinic acid derivatives through hydrophosphinylation of α-amino aldehydes". Tetrahedron 58, № 13 (2002): 2577–83. http://dx.doi.org/10.1016/s0040-4020(02)00136-9.

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26

Mohamed, Mustafa, та Michael A. Brook. "α-(Disilylallenyl) α-amino acid derivatives from the Claisen rearrangement of propargyl glycinates". Collection of Czechoslovak Chemical Communications 74, № 6 (2009): 927–34. http://dx.doi.org/10.1135/cccc2009021.

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Silylpropargyl glycinate esters undergo [3,3]-sigmatropic rearrangements to give 2-(disilylallenyl)glycine derivatives, interesting highly functional synthons, in moderate to good yield (30 to 85%) and in high diastereoselectivity when directed by a large silylpropargyl group (9:1 to 22:1). The highly functional amino acid, methyl (R)-2-(Boc-amino)-3,5-bis(trimethylsilyl)hexa-3,4-dienoate was isolated and characterized by X-ray crystal structure analysis.

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27

Kasimura, Hideaki, Keiki Kishikawa, Shigeo Kohmoto, Makoto Yamamoto та Kazutoshi Yamada. "Diastereomeric separation of α-amino acid derivatives using a chiral carbodiimide". Analytica Chimica Acta 239 (1990): 297–99. http://dx.doi.org/10.1016/s0003-2670(00)83865-9.

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28

O'Donnell, Martin J., Francisca Delgado, Curt Hostettler та Reinhard Schwesinger. "An efficient homogeneous catalytic enantioselective synthesis of α-amino acid derivatives". Tetrahedron Letters 39, № 48 (1998): 8775–78. http://dx.doi.org/10.1016/s0040-4039(98)01995-9.

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29

Krečmerová, Marcela, Milena Masojídková, and Antonín Holý. "Synthesis of N9- and N7-[2-Hydroxy-3-(phosphonomethoxy)propyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds." Collection of Czechoslovak Chemical Communications 69, no. 10 (2004): 1889–913. http://dx.doi.org/10.1135/cccc20041889.

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Base-catalyzed reactions of diethyl [(oxiranylmethoxy)methyl]phosphonate (2) with purine bases (adenine, 2,6-diaminopurine, 6-chloropurine and 2-amino-6-chloropurine) gave corresponding 9- or 7-[2-hydroxy-3-(phosphonomethoxy)propyl] purines. The adenine and 2,6-diaminopurine derivatives cyclize to cyclic phosphonates 4 and 6. The 9-[2-hydroxy-3-(phosphonomethoxy)propyl] derivatives of N6-substituted adenine and 2,6-diaminopurine (15-27) were prepared by the treatment of diethyl {[3-(6-chloropurin-9-yl)-2-hydroxypropoxy]methyl}phosphonate (11) or diethyl {[3-(2-amino-6-chloropurin-9-yl)-2-hydro

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30

Gruzdev, Dmitry A., Angelina A. Telegina, Marina A. Ezhikova, Mikhail I. Kodess, Galina L. Levit, and Victor P. Krasnov. "Synthesis of Novel Planar-Chiral Charge-Compensated nido-Carborane-Based Amino Acid." Molecules 29, no. 18 (2024): 4487. http://dx.doi.org/10.3390/molecules29184487.

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Amino acids with unusual types of chirality and their derivatives have recently attracted attention as precursors in the synthesis of chiral catalysts and peptide analogues with unique properties. In this study, we have synthesized a new nido-carborane-based planar-chiral amino acid, in the molecule of which the amino group is directly bonded to the B(3) atom, and the carboxyl group is attached to the B(9) atom through the CH2S+(Me) fragment. 3-Amino-9-dimethylsulfonio-nido-carborane, prepared in three steps from 3-amino-closo-carborane in a high yield, was a key intermediate in the synthesis

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31

Hansen, Terkel, Morten K. Moe, Trude Anderssen та Morten B. Strøm. "Metabolism of small antimicrobial β2,2-amino acid derivatives by murine liver microsomes". European Journal of Drug Metabolism and Pharmacokinetics 37, № 3 (2012): 191–201. http://dx.doi.org/10.1007/s13318-012-0086-9.

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32

Kandula, Venu, Ramakrishna Gudipati, Anindita Chatterjee, Muralidaran Kaliyaperumala, Satyanarayana Yennam та Manoranjan Behera. "A novel synthesis of chromone based unnatural $$\upalpha $$ α -amino acid derivatives". Journal of Chemical Sciences 129, № 8 (2017): 1233–45. http://dx.doi.org/10.1007/s12039-017-1328-9.

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33

Behjet, Shaimaa A., and Zahraa F. Khudair. "Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (Anti-Bacteria)." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 01 (2020): 38–44. http://dx.doi.org/10.25258/ijpqa.11.1.6.

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Introduction: In this work synthesis, many kinds of heterocyclic derivatives by many steps, the first we preparation 1-(4-((1H-imidazol_2-yl-) diazenyl) phenyl) ethan-1_one. (1) by coupling of diazonium salt of p-amino acetophenone with imidazole in alkaline alcoholic media, the second step include react (1) with 2_amino_6_methylpyrimidin _4_ol in acid medium to get Schiff base derivatives(2)the last step include react(2) with (sodium azide, thioglycolic acid, glycine, alanine, Tryptophan, (2 aminobenzoic acid), (2-mercaptobenzoic acid) to give (tetrazole(3), thiazolidine(4), imidazolidine(5-7

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34

Seprődi, János, Judit Érchegyi, Zsolt Vadász, et al. "Potent GnRH agonists containing L-amino acid derivatives in the six position." Biochemical and Biophysical Research Communications 144, no. 3 (1987): 1214–21. http://dx.doi.org/10.1016/0006-291x(87)91440-9.

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35

Möhrle, Hans, and Hubertus Folttmann. "Modellreaktionen zur Plumbagin-Synthese, 2. Mitteilung 5-Amino-1-naphthol als Startkomponente / Model Reactions for Plumbagin Synthesis, 2nd Communication 5-Amino-1-naphthol as Starting Compound." Zeitschrift für Naturforschung B 42, no. 12 (1987): 1578–84. http://dx.doi.org/10.1515/znb-1987-1215.

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AbstractThe aminomethylation of 5-amino-1-naphthol (1) and 5-acetamido-1-naphthol (9) is examined. While the hydrogenolysis of the phenol Mannich bases derived from 1 cannot be accomplished, the derivatives of 9 react easily. The oxidation of the 2-methylphenol compounds 5 and 18 to the corresponding quinones may performed with Fremy's salt. The following transforming of the amino to the hydroxy group by nitrosylsulfuric acid succeeds with small yield only.

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36

van Leuken, R. G. J., A. L. L. Duchateau, and G. T. C. Kwakkenbos. "Thermospray liquid chromatography/mass spectrometry study of diastereomeric isoindole derivatives of amino acids and amino acid amides." Journal of Pharmaceutical and Biomedical Analysis 13, no. 12 (1995): 1459–64. http://dx.doi.org/10.1016/0731-7085(95)01580-9.

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37

Lukashuk, O. I., E. R. Abdurakhmanova, K. M. Kondratyuk, et al. "Introduction of chiral 2-(aminoalkyl) substituents into 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives and their use in phosphonodipeptide synthesis." RSC Advances 5, no. 15 (2015): 11198–206. http://dx.doi.org/10.1039/c4ra13819h.

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Starting from phthalimidoalkanoylamines 1 we have suggested a synthetic route to 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives 5 , which have been further used to obtain phosphonodipeptides 8, 9, and 10 with the original optical purity retained.

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38

Todorova, Daniela, Maria Tupova, Veneta Zapreva, Tsenka Milkova, and Atanas Kujumdjiev. "Transformation of Aminosteroids into Pharmacologically Active Amides of Phenolic Acids." Zeitschrift für Naturforschung C 54, no. 1-2 (1999): 65–69. http://dx.doi.org/10.1515/znc-1999-1-212.

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Amides of cinnamic acid derivatives with 3α-and 3β-cholestanylamines, as well as with 3α-and 3β-amino-(2’-aminoethyl)-cholest-5-en were synthesized using dicyclohexylcarbodiimide (DCC) and 1-hydroxy-benzotriazole as efficient additives. Their structure was determined by UV and 1HNMR . 3β-Amino-(2’-aminoethyl)-cholest-5-en, amides of p-hydroxy-cinnamic acid 4 and 9, and N-cholest-5-en-3α-aminoethyl-di-(3’’,-phenyl-trans-2’’-propene)-amide 10 showed moderate antibacterial activity against Staphylococcus aureus

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39

Kuhl, Peter, Simone S�uberlich, and Hans-Dieter Jakubke. "Model studies on protease-catalysed peptide synthesis using 9-fluorenylmethoxycarbonyl protected amino acid derivatives." Monatshefte f�r Chemie Chemical Monthly 123, no. 11 (1992): 1015–22. http://dx.doi.org/10.1007/bf00810932.

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40

Uppal, Komal, Richa Nijhawan, and Sunil Kumar Polipalli. "Plasma Amino Acids Profile: Established Reference Range in Indian Children." International Journal of Health Sciences and Research 13, no. 11 (2023): 304–9. http://dx.doi.org/10.52403/ijhsr.20231136.

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Reference values were determined for 17 plasma free amino acids from measurements done in 248 healthy children ranging from 0 to 12 years of age. The method used is based on precolumn derivatization of primary amino acids with o-phthalaldehyde (OPA) and 9-fluorenylmethy[l] chloroformate (FMOC) for secondary amino acids, separation of the derivatives by reversed-phase chromatography, and quantification by fluorescence detection. We propose to present the age-specific distribution of plasma amino acid concentrations. Complete separation was achieved within 18 min. Total analysis time, including

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41

F. Mahdi, Monther. "Synthesis and Preliminary Pharmacological Evaluation of Aminobenzensulfonamides Derivatives of Mefenamic Acid as a Potential Anti-inflammatory Agents." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 17, no. 1 (2017): 7–15. http://dx.doi.org/10.31351/vol17iss1pp7-15.

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A group of amino derivatives [4-aminobenzenesulfonamide,4-amino-NÂ¹ methylbenzenesulfonamide, or NÂ¹-(4-aminophenylsulfonyl)acetamide] bound to carboxyl group of mefenamic acid a well known nonsteroidal anti-inflammatory drugs (NSAIDs) were designed and synthesized for evaluation as a potential anti-inflammatory agent. In vivo acute anti-inflammatory activity of the final compounds (9, 10 and 11) was evaluated in rat using egg-white induced edema model of inflammation in a dose equivalent to (7.5mg/Kg) of mefenamic acid. All tested compounds produced a significant reduction in paw edema with r

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42

Weisz, Imre, John Roboz, Imre Wolf, Jozsef Szabo та J. George Bekesi. "Synthesis of diacylamines and the preparation of α-amino-acylureas, a new type of α-amino acid derivatives". Bioorganic & Medicinal Chemistry Letters 8, № 22 (1998): 3241–44. http://dx.doi.org/10.1016/s0960-894x(98)00593-9.

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43

Bovy, Phillipe R., Joseph Rico, Thomas E. Rogers, Foe S. Tjoeng, and Jeffery Zablocki. "Substituted beta-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof." Transfusion Science 15, no. 1 (1994): iv. http://dx.doi.org/10.1016/0955-3886(94)90077-9.

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44

O. Moustafa, Gaber, Abdulrahman A. Almehizia, Ahmed M. Naglah, and Amer A. Zen. "Synthesis of some novel dipeptides and their copper(II) complexes of (dibenzo [b, d] furan-2-ylsulfonyl) phenylalanine." Bulletin of the Chemical Society of Ethiopia 39, no. 2 (2024): 301–11. http://dx.doi.org/10.4314/bcse.v39i2.9.

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A new series of dipeptide candidates (6-11) and corresponding octahedral copper complexes (12-15) were prepared by the synthesis of dibenzofuran-2-sulfonyl chloride (3). Then, the acid chloride (3) was coupled, at low temperature, with DL-phenylalanine using triethylamine and gave the corresponding acid (4) as starting material, which was converted to dibenzofuran-2-sulphonyl-DL-phenylalanyl chloride (5) using thionyl chloride. The latter acid chloride (5) was coupled with some aliphatic amino acids and gave the corresponding dibenzofuran-2-sulphonyldipeptide candidates (6, 7). Moreover, diben

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45

Ilkimen, Halil. "Synthesis and characterization of mixed ligand Cu(II) complexes of 2-methoxy-5-sulfamoylbenzoic acid and 2-aminopyridine derivatives." Macedonian Journal of Chemistry and Chemical Engineering 38, no. 1 (2019): 13. http://dx.doi.org/10.20450/mjcce.2019.1698.

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A novel Cu(II) complex 1 of 2-methoxy-5-sulfamoylbenzoic acid (Hsba) and eight novel mixed-ligand Cu(II) complexes 2–9 have been prepared using Hsba and 2-aminopyridine derivatives [2,3-diaminopyridine (2,3dap), 2,3-diamino-5-bromopyridine (2,3da5Brp), 2,3-diamino-5-chloropyridine (2,3da5Clp), 2-amino-3-benzyloxypyridine (2a3bxp), 2-amino-3-hydroxypyridine (2a3OHp), 2-amino-3-methylpiridine (2a3mp), 2-amino-3-methyl-6-ethylpiridine (2a3m6Etp) and 2-amino-3-nitro-6-methylpiridine (2a3NO26mp)], respectively. The structures of the amorphous metal complexes have been proposed by evaluating the dat

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46

N., B. Patel, and N. Agravat S. "Synthesis, characterization and biological screening of some new pyridine derivatives." Journal of Indian Chemical Society Vol. 84, Aug 2007 (2007): 785–91. https://doi.org/10.5281/zenodo.5824938.

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Department of Chemistry, Veer Narmad South Gujarat University, Surat-395 007, Gujarat, India <em>E-mail</em>: drnavin @satyam.net.in; snagravat@yahoo.co.in <em>Manuscript received 18 August 2006, revised 26 March 2007, accepted 13 June 2007</em> 2-Amino substituted benzothiazole 2<sub>1_12</sub> and<em> p</em>-acetamidobenzenesulfonyl chloride 1 were used to prepare <em>N"</em>-(<em>p</em>anilinosulfonamido) substitutedbenzothiazole 4<sub>1_12</sub> using mixture of pyridine and acetic anhydride which formed (<em>N</em>-acetyl pyridinium) an cleetrophilic complex which facilitated condens

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Hamid Mohammed Saleh Al-Jubori. "Synthesis And Identification Of from HEMA Schiff Base Derivatives Contains Aldehyde Group For Hexa and Hepta Cyclization." Tikrit Journal of Pure Science 22, no. 1 (2023): 83–94. http://dx.doi.org/10.25130/tjps.v22i1.612.

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In this research the polymer which contains aldehyde group [H1] has been prepared by oxidation [H] using the oxidizing agent (Dess Martin Periodinane), [H1] has been dialyzed by ethanol, Schiff bases[H2,H5andH8] compounds have been prepared through the reaction of compound [H1] with appropriate amines, [H3] compound which contains hydroquinazolin ring has been prepared by the reaction of [H2] compound with 2-amino benzoic acid.[H4]which has been prepared by cyclization reaction of compound [H2] with phthalic anhydride. compounds [H6,H7]were prepared by the reaction of [H5] compound with 2-amin

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Hafedh, Fadhel R., Hamid H. Mohammed, and Zainab N. Mageed. "Synthesis and Characterization of Novel Pyrimido [1,2-a] benzimidazole and its Derivatives." Al-Mustansiriyah Journal of Science 33, no. 1 (2022): 15–20. http://dx.doi.org/10.23851/mjs.v33i1.1020.

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A few pyrimido[1,2-a] benzimidazole derivatives had been synthesized, derived from 4-amino-2-(4-chloro or bromophenyl) -1,2-dihydropyrimido[1,2-a] benzimidazole-3-carbonitrile (4 or 5) is made through one pot three components condensation reaction of 1H-benzimidazol-2-amine (1) with p-chloro or bromobenzaldehyde (2) and malononitrile (3). First part of these derivatives prepared by reaction compound (4 or 5) with acetic acid or propionic acid in presence POCl3 to give pyrmidino rings (6-9). Second part of derivatives were prepared by reaction compound (4 or 5) with benzoyl chloride or phenylis

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M., K. A. IBRAHIM, S. EL-GHARIB M., M. FARAG A., and R. H. ELMOGHAYER M. "Reaction of Ethyl Chloroglyoxalate Arylhydrazone with Heterocyclic Amidine and Difunction Amino Derivatives." Journal of Indian Chemical Society Vol. 65, Mar 1988 (1988): 194–96. https://doi.org/10.5281/zenodo.6035359.

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Chemistry Department, Faculty of Science, Cairo University, Giza, A. B. Egypt <em>Manuscript received 10 November 1986, revised 9 November 1987, accepted 13 January 1988</em> The ethyl chloroglyoxalate <em>p</em>-tolylhydrazones (1) react with 5-amino-3-phenyl- pyrazole, 3-aminotriazole and 2-aminobenzimidazole in triethylamine solution to give the corresponding pyrazolo[4,5-<em>c</em>]pyrazole (9), triazolo[4,5-<em>c</em>]triazole (12) and  benzimidazolylamidrazone derivatives (14), respectively. The reaction mechanism has been suggested as 1,3-dipolar cycloaddition of nitrileimine

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50

Freiesleben, Doris, Kurt Polborn, Christian Robl, Karlheinz Sünkel, and Wolfgang Beck. "Metal complexes of biologically important ligands, LXXVIII. Synthesis of palladium complexes of ferrocenyl-substituted amino acid derivatives." Canadian Journal of Chemistry 73, no. 7 (1995): 1164–74. http://dx.doi.org/10.1139/v95-143.

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Schiff bases from ferrocene aldehyde and α-amino acidates react with PdCl2 or Na2PdCl4 to give N,O-chelate complexes (2a–e, 3). The related N-ferrocenylmethylen-α-amino acid esters give, with Pd(OAc)2, cyclopalladated acetate-bridged complexes (4a,b). N,O-chelate complexes (5–7) are obtained from Na2PdCl4 with N-ferrocenylmethyl prolinate and-alaninate as well as with N,N-dibenzyl glycinate. The ethyl ester of N,N-dibenzylglycine and Pd(OAc)2 form the cyclopalladated acetate-bridged complex 8, while the ester of N-monobenzylglycine and Na2PdCl4 affords trans-PdCl2(L)2 with a monodentate N-coor

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