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Relevant bibliographies by topics / A-740003

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Journal articles

Academic literature on the topic 'A-740003'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "A-740003"

1

Janssen, Bieneke, Danielle J. Vugts, Uta Funke, et al. "Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation." J Labelled Comp Radiopharm. 57, no. 8 (2014): 509–16. https://doi.org/10.1002/jlcr.3206.

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Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X7 receptor is upregulated. A-740003, a highly affine and selective P2X7 receptor antagonist, is a promising candidate for the development of a radiotracer for imaging of neuroinflammation by positron emission tomography. For this purpose, [11C]A-740003 was synthesised and evaluated in vivo with respect to both tracer metabolism and biodistribution. In plasma, a moderate metabolic rate was seen. In healthy

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2

Janssen, Bieneke, Danielle J. Vugts, Uta Funke, et al. "Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation." Journal of Labelled Compounds and Radiopharmaceuticals 57, no. 8 (2014): 509–16. http://dx.doi.org/10.1002/jlcr.3206.

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3

Honore, Prisca, Diana Donnelly-Roberts, Marian T. Namovic, et al. "A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat." Journal of Pharmacology and Experimental Therapeutics 319, no. 3 (2006): 1376–85. http://dx.doi.org/10.1124/jpet.106.111559.

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4

Grol, Matthew W., Irene Zelner, and S. Jeffrey Dixon. "P2X7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells." American Journal of Physiology-Endocrinology and Metabolism 302, no. 5 (2012): E561—E575. http://dx.doi.org/10.1152/ajpendo.00209.2011.

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The P2X7 receptor is an ATP-gated cation channel expressed by a number of cell types, including osteoblasts. Genetically modified mice with loss of P2X7 function exhibit altered bone formation. Moreover, activation of P2X7 in vitro stimulates osteoblast differentiation and matrix mineralization, although the underlying mechanisms remain unclear. Because osteogenesis is associated with enhanced cellular metabolism, our goal was to characterize the effects of nucleotides on metabolic acid production (proton efflux) by osteoblasts. The P2X7 agonist 2′,3′- O-(4-benzoylbenzoyl)ATP (BzATP; 300 μM) i

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5

Avdispahić, Muharem. "Effective bounds for Huber’s constant and Faltings’s delta function." Mathematics of Computation 90, no. 331 (2021): 2381–414. http://dx.doi.org/10.1090/mcom/3631.

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By a closer inspection of the Friedman-Jorgenson-Kramer algorithm related to the prime geodesic theorem on cofinite Fuchsian groups of the first kind, we refine the constants therein. The newly obtained effective upper bound for Huber’s constant is in the modular surface case approximately 74000 74000 -times smaller than the previously claimed one. The degree of reduction in the case of an upper bound for Faltings’s delta function ranges from 10 8 10^{8} to 10 16 10^{16} .

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6

Beale, D., and J. Hopley. "A bovine epithelial membrane protein that binds polymeric immunoglobulin and has a structure related to that of bovine secretory component." Biochemical Journal 233, no. 1 (1986): 37–40. http://dx.doi.org/10.1042/bj2330037.

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A protein of Mr 94000 was isolated from detergent-solubilized bovine intestinal, liver and mammary-gland membranes. It binds immunoglobulin M and also undergoes proteolytic fragmentation in a similar manner to bovine secretory component (Mr 74000). The affinity-purified membrane protein is therefore most likely to be the bovine epithelial receptor for polymeric immunoglobulin. A structural model is proposed.

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7

Gray, S. R., F. R. Batstone, N. F. Santiapillai, and P. J. Richardson. "Solubilization and purification of a putative quisqualate-sensitive glutamate receptor from crustacean muscle." Biochemical Journal 273, no. 1 (1991): 165–71. http://dx.doi.org/10.1042/bj2730165.

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Two high-affinity glutamate-binding proteins have been solubilized and purified from crustacean muscle membranes. L-[3H]Glutamate binding to intact membranes gave IC50 values (concn. giving 50% inhibition) of 0.35 microM for glutamate. 9.0 microM for quisqualate and 36.2 microM for ibotenic acid. Kainate, domoate, N-methyl-D-aspartate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, D-glutamate and L-aspartate were poor inhibitors of glutamate binding. The two protein were purified approx. 600-fold from muscle membranes by use of concanavalin A and gel-filtration column chromatography. O

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8

Rao, E. V. S. Prakasa, Munnu Singh, and R. S. Ganesha Rao. "Effect of plant spacing and application of nitrogen fertilizer on herb and essential oil yields of palmarosa (Cymbopogon martini Stapf. var. motia)." Journal of Agricultural Science 104, no. 1 (1985): 67–70. http://dx.doi.org/10.1017/s0021859600042994.

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SummaryA field experiment was conducted for 2 years during the crop seasons of 1980–2 to study the effect of diverse plant spacings and rates of nitrogen application on the yields of herb and essential oil of palmarosa (Cymbopogon martini Stapf. var. motia). The results indicated that at closer plant spacings of 30 × 30 cm (110 000 plants/ha) and 45 × 30 cm (74000 plants/ha), palmarosa responded to higher amounts of N fertilizer (240 kg N/ha/year). It was suggested that a plant spacing of 30 × 30 and 45 × 30 cm and application of 240 kg N/ha/year result in high essential oil yield of palmarosa

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9

Lu, Peng Xian, and Man Man Lu. "Largely Enhanced Figure of Merit for CoSb₃Thermoelectric Material by Introducing Disordered Structure." Applied Mechanics and Materials 189 (July 2012): 87–91. http://dx.doi.org/10.4028/www.scientific.net/amm.189.87.

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To enhance the Seebeck coefficient and reduce the thermal conductivity and meanwhile keep an excellent electrical conductivity, the disordered structure was introduced into the ordered CoSb3 nanocrystalline by increasing hot-pressing temperature. The results show that the introduced disordered structure can increase the Seebeck coefficient from 125 VK-1 to 390 VK-1 measured at 773K, the thermal conductivity can be reduced from 1.94 Wm-1K-1 to 1.73 Wm-1K-1. Even though the electrical conductivity is decreased from 74000 Sm-1 to 14000 Sm-1, a largely enhanced figure of merit of 1.21 at

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10

Izquierdo, Manuel Arturo. "Contributions to the study of the Muisca calendar." Proceedings of the International Astronomical Union 7, S278 (2011): 106–17. http://dx.doi.org/10.1017/s174392131101252x.

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AbstractThe aim of this work is to review and expand upon the model proposed by Father José Domingo Duquesne de la Madrid (1745–1821) regarding the calendar of the pre-Columbian Muisca culture of central Colombia. This model was dismissed by scholars in the late 19th century when it was called just a simple invention of a clergyman; however, a detailed analysis shows that his interpretation of the calendar was based on genuine ethnographic information. According to Duquesne, this calendar was based on a series of moons whose multiples are 5, 20 and 37. These multiples generate time series that

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