Relevant bibliographies by topics / Acidic tumor microenvironment

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Acidic tumor microenvironment'

Author: Grafiati
Published: 15 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Acidic tumor microenvironment"

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Qu, Fanli, Guanwen Wang, Ningning Zhang, Qing Shao, and Xiaohua Zeng. "Abstract P3-02-29: The mechanism of acidic microenvironment promotes tumor-associated macrophages secreting glutamine to activate dual signaling pathways of mTORC1 and c-MYC in CDK4/6 inhibitor resistance of ER-positive breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–02–29—P3–02–29. https://doi.org/10.1158/1557-3265.sabcs24-p3-02-29.

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Abstract Resistance to CDK4/6 inhibitors in ER-positive breast cancer poses a clinical challenge, and the underlying mechanisms remain unclear. ER serves as a crucial regulator of glycolysis, promoting tumor progression and resistance by inducing microenvironmental acidification. We observed that an acidic microenvironment induces the polarization of tumor-associated macrophage (TAM) toward the M2 phenotype, leading to the secretion of glutamine. This activation of mTOR promotes resistance to CDK4/6 inhibitors in ER-positive breast cancer. Concurrently, glutamine promotes the upregulation of c
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Böhme, Ines, and Anja Katrin Bosserhoff. "Acidic tumor microenvironment in human melanoma." Pigment Cell & Melanoma Research 29, no. 5 (2016): 508–23. http://dx.doi.org/10.1111/pcmr.12495.

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Feng, Liangzhu, Ziliang Dong, Danlei Tao, Yicheng Zhang, and Zhuang Liu. "The acidic tumor microenvironment: a target for smart cancer nano-theranostics." National Science Review 5, no. 2 (2017): 269–86. http://dx.doi.org/10.1093/nsr/nwx062.

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Abstract The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in uti
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Liu, Yu-Cheng, Zhi-Xian Wang, Jing-Yi Pan, et al. "Recent Advances in Imaging Agents Anchored with pH (Low) Insertion Peptides for Cancer Theranostics." Molecules 28, no. 5 (2023): 2175. http://dx.doi.org/10.3390/molecules28052175.

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The acidic extracellular microenvironment has become an effective target for diagnosing and treating tumors. A pH (low) insertion peptide (pHLIP) is a kind of peptide that can spontaneously fold into a transmembrane helix in an acidic microenvironment, and then insert into and cross the cell membrane for material transfer. The characteristics of the acidic tumor microenvironment provide a new method for pH-targeted molecular imaging and tumor-targeted therapy. As research has increased, the role of pHLIP as an imaging agent carrier in the field of tumor theranostics has become increasingly pro
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Hasegawa, Manami, Keisuke Maede, Miyuki Nishida, et al. "Abstract 1511: Cancer adaptation to acidic tumor microenvironment." Cancer Research 85, no. 8_Supplement_1 (2025): 1511. https://doi.org/10.1158/1538-7445.am2025-1511.

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Cancer cells exhibit a characteristic metabolic pattern known as the Warburg effect, which upregulates glycolysis even in aerobic environments. As a result, cancer cells are exposed to an acidic environment due to enhanced excretion of proton and lactate. We have previously reported that this acidic tumor microenvironment induces the activation of the cholesterol biosynthesis pathway and the accumulation of N1-acetylspermidine. Although the acidic tumor microenvironment is known to suppress cancer cell proliferation, the survival strategies employed by cancer cells under such harsh conditions
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Jin, Haojie, Ning Wang, Cun Wang, and Wenxin Qin. "MicroRNAs in hypoxia and acidic tumor microenvironment." Chinese Science Bulletin 59, no. 19 (2014): 2223–31. http://dx.doi.org/10.1007/s11434-014-0273-y.

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Sharma, Vishal, та Jagdeep Kaur. "Acidic environment could modulate the interferon-γ expression: Implication on modulation of cancer and immune cells’ interactions". Asian Biomedicine 17, № 2 (2023): 72–83. http://dx.doi.org/10.2478/abm-2023-0047.

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Abstract Background In rapidly growing solid tumors, insufficient vascularization and poor oxygen supply result in an acidic tumor microenvironment, which can alter immune response. Objective To investigate the role of the acidic microenvironment in immune response modulation along with cancer and immune cells’ interactions. Method To mimic the tumor microenvironment conditions, T cells (Jurkat), macrophages (THP-1), and HeLa (cervical) cells were cultured under acidic conditions (pH 6.9, pH 6.5) and physiological pH (7.4). The HeLa cell culture medium was exploited as a tumor cell conditioned
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Boedtkjer, Ebbe, and Stine F. Pedersen. "The Acidic Tumor Microenvironment as a Driver of Cancer." Annual Review of Physiology 82, no. 1 (2020): 103–26. http://dx.doi.org/10.1146/annurev-physiol-021119-034627.

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Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH influence cancer and stromal cell function, their mutual interplay, and their interactions with the extracellular matrix. Tumor pH is spatially and temporally heterogeneous, and the fitness advantage of cancer cells adapted to extracellular acidity is likely particularly evident when they encounter less acidic tumor regions, for instance, during invasion. Throu
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Wayne Chang, Wun-Shaing. "Abstract B002: Dynamic response and evolving adaptation of pancreatic cancer cells to the prolonged acidic pH microenvironment." Cancer Research 84, no. 22_Supplement (2024): B002. http://dx.doi.org/10.1158/1538-7445.tumbody-b002.

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Abstract Solid tumor cells are often immersed in an acidic microenvironment. While many previous studies have investigated the short-term effects of extracellular acidity on tumor cells, little is known about how they adapt to the prolonged acidic microenvironmental stress and then advance to more aggressive stages. By challenging pancreatic tumor cells as an example with continuously and gradually acidified extracellular pH, a variety of cellular characteristics including phenotypic regulation, proliferation rates, autophagic control, metabolic plasticity and metastatic potentials were identi
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Kyriazi, Athina A., Makrina Karaglani, Sofia Agelaki, and Stavroula Baritaki. "Intratumoral Microbiome: Foe or Friend in Reshaping the Tumor Microenvironment Landscape?" Cells 13, no. 15 (2024): 1279. http://dx.doi.org/10.3390/cells13151279.

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The role of the microbiome in cancer and its crosstalk with the tumor microenvironment (TME) has been extensively studied and characterized. An emerging field in the cancer microbiome research is the concept of the intratumoral microbiome, which refers to the microbiome residing within the tumor. This microbiome primarily originates from the local microbiome of the tumor-bearing tissue or from translocating microbiome from distant sites, such as the gut. Despite the increasing number of studies on intratumoral microbiome, it remains unclear whether it is a driver or a bystander of oncogenesis
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Dissertations / Theses on the topic "Acidic tumor microenvironment"

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Audero, Madelaine. "Acidic tumor microenvironment and Ca2+ signaling interplay in Pancreatic Ductal Adenocarcinoma (PDAC) progression." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS105.

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L'adénocarcinome canalaire pancréatique (PDAC) est une maladie mortelle caractérisée par un micro-environnement tumoral (TME) extrêmement acide (˂pHe 6,5) qui joue un rôle important dans son début et sa progression. Dans ce contexte, les canaux ioniques perméables au Ca2+ représentent de bons candidats cibles en raison de leur capacité à intégrer des signaux provenant de la TME. Les canaux Ca2+ sont en effet des capteurs de pH capables d'intégrer les signaux de la TME pour activer les voies intracellulaires en aval liées à la progression du PDAC. Bien que les rôles de l'acidose tumorale et de
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Schnipper, Julie. "The impact of the acidic tumor microenvironment on ion channel expression and regulation, in the progression of pancreatic ductal adenocarcinoma." Electronic Thesis or Diss., Amiens, 2022. http://www.theses.fr/2022AMIE0071.

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Le canal TRPC1 (pour transient receptor potential canonical 1) est l'un des canaux cationiques non sélectifs les plus impliqués dans plusieurs maladies, y compris la progression du cancer. Les TRPC peuvent être activés par différents stimuli physico-chimiques dont le pH. Par ailleurs, l'une des caractéristiques du cancer représente les variations pH extracellulaire, notamment dans l'adénocarcinome canalaire pancréatique (ACP). Il existe de fortes indications quant à l'agressivité de l'ACP qui est causée par l'interaction entre le microenvironnement acide de la tumeur et la dérégulation des can
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Assi, E. "ROLE OF ACID SPHINGOMYELINASE IN THE TUMOUR MICROENVIRONMENT." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229416.

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Defective apoptosis represents one of the major causative factors in the development and progression of cancer. The ability of tumour cells to evade engagement of apoptosis can play a significant role in their resistance to conventional therapeutic regimens. In the last few years, preclinical and clinical studies have indicated ceramide and the enzymes of its metabolism, in particular Acid Sphingomyelinase (A-SMase) which hydrolyzes sphingomyelin to ceramide and phosphocoline, as key players in tumour physiopathology. Different cancers have been shown to have reduced ceramide levels and, of in
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Al-Husari, Maymona. "Mathematical modelling of the tumour microenvironment : the causes and consequences of tumour acidity." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18965.

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Extracellular acidity and high levels of lactate are commonly observed in solid tumours. Some tumours also exhibit a reversed cellular pH gradient with an intracellular pH that is higher than the extracellular. This has been shown to play a crucial part in not only the invasive and metastatic cascade of tumours, but also on their response to therapies. In this thesis, we present four different mathematical models that examine the possible causes of tumour acidity and its effect on cell metabolism and tumour invasion. In the second chapter, we derive an ordinary differential equation model that
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Timosenko, Elina. "Tryptophan catabolism and amino acid transporter reprogramming in the tumour microenvironment." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:33745777-7aab-4342-b997-fc4317ec34fb.

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A large proportion of human tumours exploit tryptophan catabolism as a means to suppress T cell activity in the tumour microenvironment. However, the mechanisms that allow tumour cells to resist the detrimental effects of local tryptophan depletion have so far remained obscure. Here we demonstrate that shortage of tryptophan induced by the expression of tryptophan-degrading enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) results in ATF4-dependent reprogramming of the amino acid transporter expression profile in tumour cells. Specifically, we show that tumour cell
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Silva, Lídia [Verfasser], and Rüdiger [Akademischer Betreuer] Hell. "Branched-chain amino acid metabolism in the tumor microenvironment interaction / Lidia Silva ; Betreuer: Rüdiger Hell." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177148897/34.

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Alruwaili, Waad A. "Conjugated Bile Acid and Sphingosine 1-phosophate prompt Cholangiocarcinoma Cell Growth via Releasing Exosomes." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5715.

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Cholangiocarcinoma (CCA) is a fatal primary malignancy that is formed in the bile ducts. Cancer-associated myofibroblasts play a crucial role in CCA proliferation and invasion. Furthermore, there is a growing interest in the role of the exosome in the interaction between the cancer-associated myofibroblasts and cholangiocarcinoma which lead to CCA growth. However how cholangiocarcinoma-derived exosome affect the cancer-associated myofibroblasts in the tumor microenvironment remain unknown. In this study, we examined whether exosome produced by cholangiocarcinoma could involve in the prompt of
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Dong, Jihu. "Physiopathologie de cellules souches cancéreuses isolées de glioblastomes primitifs et évaluation pré-clinique de molécules "tête de série" par une approche de biologie et de chimie médicinale." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ036/document.

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Les glioblastomes sont des tumeurs primaires du cerveau les plus malignes. L’identification des cellules souches cancéreuses de glioblastome (CSGs) a transformé notre vision globale des glioblastomes en révélant une hiérarchie cellulaire au sein de ces tumeurs. Les CSGs sont douées de propriétés d’auto-renouvellement, de différenciation et peuvent entrer en quiescence. Elles sont considérées comme les cellules entretenant les tumeurs, responsables de leur dissémination et des rechutes après traitement. La découverte des CSGs a conduit à un changement de paradigme dans le développement des thér
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Sadiq, Barzan A. "A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278056.

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Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector proteins involved in regulation of cell migration, metabolism and growth. The importance of this network is evidenced by the relatively high frequency with which cancers acquire gain-of-function mutations in this pathway and huge efforts to make PI3K inhibitors to treat cancer. The canonical
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Tang, Ching-Chun, and 湯景鈞. "Study on Acidic Tumor Microenvironment in Oral Cancer." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/m37yv5.

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碩士<br>國立臺灣大學<br>口腔生物科學研究所<br>107<br>The microenvironment of cancer cells is considered to be an important indicator of cancer progression. Studies have shown that due to the specific metabolic mechanisms of cancer cells, the extracellular matrix of cell has a higher hydrogen ion concentration than the cytoplasm. Exposure of cancer cells to this environment has an effect on their function, including changing in the metabolic system, mediating the growth processes, and expression of autophagy proteins. Compared with cancer within other parts of the body, the oral cavity is the only access to the
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Books on the topic "Acidic tumor microenvironment"

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Goode, Jamie A., and Derek J. Chadwick, eds. The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity. John Wiley & Sons, Ltd, 2001. http://dx.doi.org/10.1002/0470868716.

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Jamie, Goode, Chadwick Derek, Novartis Foundation, and Symposium on the Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity (2000 : London, England), eds. The tumour microenvironment: Causes and consequences of hypoxia and acidity. Wiley, 2001.

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Goode, Jamie A., Derek J. Chadwick, and Novartis Foundation Symposium Staff. Tumour Microenvironment No. 240: Causes and Consequences of Hypoxia and Acidity. Wiley & Sons, Incorporated, John, 2008.

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Boyer, Michael Joseph. Tumor acidity and the influence of microenvironment on the regulation of intracellular pH: implications for therapy. 1993.

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The Tumour Microenvironment - No. 240: Causes and Consequences of Hypoxia and Acidity (Novartis Foundation Symposia). Wiley, 2001.

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Book chapters on the topic "Acidic tumor microenvironment"

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Ye, Zhizhou, and Donald E. Ayer. "Response to Acidity: The MondoA–TXNIP Checkpoint Couples the Acidic Tumor Microenvironment to Cell Metabolism." In Molecular Genetics of Dysregulated pH Homeostasis. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1683-2_5.

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Riemann, Anne, M. Rauschner, M. Gießelmann, S. Reime, and O. Thews. "The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as Well as Adhesion of NCI-H358 Lung Cancer Cells." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-48238-1_28.

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Brix, Nikko, and Kirsten Lauber. "Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms and Resistance Mechanisms." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23175-9_2.

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AbstractImmune checkpoint inhibition has emerged as an integral part of the standard-of-care for head and neck squamous cell carcinoma (HNSCC) in recurrent and/or metastatic stages. Clinical responses are impressive but remain limited to a minority of patients. Primary resistance of never-responders is considered to derive from host- and tumor-specific characteristics, the latter comprising tumor immune checkpoint activity, immune contexture, tumor mutational burden, neo-antigen load, and others. Secondary resistance of initially responding patients in addition, appears to be driven predominan
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Jung, Jin G., and Anne Le. "Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts." In The Heterogeneity of Cancer Metabolism. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_15.

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AbstractAlthough cancer has classically been regarded as a genetic disease of uncontrolled cell growth, the importance of the tumor microenvironment (TME) [1, 2] is continuously emphasized by the accumulating evidence that cancer growth is not simply dependent on the cancer cells themselves [3, 4] but also dependent on angiogenesis [5–8], inflammation [9, 10], and the supporting roles of cancer-associated fibroblasts (CAFs) [11–13]. After the discovery that CAFs are able to remodel the tumor matrix within the TME and provide the nutrients and chemicals to promote cancer cell growth [14], many
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Bossi, Paolo, and Erika Stucchi. "Treatment of OPMD and First Results of Immune Checkpoint Inhibitors." In Critical Issues in Head and Neck Oncology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-84539-0_3.

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Abstract Oral potentially malignant diseases (OPMDs) are a group of oral mucosal lesions that have a higher chance of turning into cancer. They show up in different ways, have different causes, and look differently on a microscopic level. To date, there are no clinical or histological factors that could predict the OPMDs’ malignant transformation to oral squamous cell carcinoma (OSCC), except for previous OSCC and WHO classification. Early diagnosis appears to be essential in these lesions in order to identify the risk of malignant progression and treat them accordingly. The standard treatment
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Jin, Cheng, You-Yi Liu, and Bo-Shi Wang. "Mechanisms of Hepatocarcinogenesis Development in an Acidic Microenvironment." In Liver Cancer - Genesis, Progression and Metastasis [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108559.

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Liver cancer represents one of the most common solid tumors globally. Despite curative improvements made in liver cancer therapy these years, the 5-year survival rate of liver cancer remains poor. Understanding the mechanisms involved in the initiation and progression of liver cancer is essential for optimizing therapeutic strategies. In recent years, it has been discovered that the acidic tumor microenvironment attributed to increased glycolysis, and hypoxia contributes to liver cancer progression through promoting cancer cell proliferation, metabolic adaptation, and migration and invasion. I
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Huang, Zhixian, and Yunchun Zhao. "Application Research of Cloud Computing and Intelligent Manufacturing in Anti-Tumor Responsive Drug Carriers." In Advances in Transdisciplinary Engineering. IOS Press, 2025. https://doi.org/10.3233/atde241377.

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In order to improve the precise delivery of anti-tumor drugs, intelligent manufacturing and cloud computing technologies are adopted to design and optimize responsive drug carriers. Through the specific response of the tumor microenvironment (acidity, temperature, enzymes, etc.), controlled release and targeted delivery of drugs are achieved. The results showed that the pH responsive carrier achieved a drug release rate of 85% in acidic tumor environments, while the intracellular drug release of the enzyme responsive carrier was 65 μ g/mg. PEGylation modification effectively prolonged the in v
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"Fluorescence Nanoprobe Imaging Tumor by Sensing the Acidic Microenvironment." In Nanomedicine and Cancer. CRC Press, 2011. http://dx.doi.org/10.1201/b11516-11.

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Hermanus Johannes Sliepen, Sonny. "Bone Cancer Pain, Mechanism and Treatment." In Recent Advances in Bone Tumours and Osteoarthritis. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95910.

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The world health organization (WHO) has predicted a global amount of 19 million cancer cases by 2025. Breast, prostate and lung cancer are common cancer types and show metastasis in 60 to 84% of the cases, with 75 to 90% experiencing life-altering cancer-induced bone pain (CIBP), characterized by continuous, dull progressive pain with movement-induced incident peaks and random breakthrough spikes. Therefore, it is the most difficult pain condition to treat. CIBP is a unique type of pain with neuropathic and nociceptive components. Briefly, an invading tumor cell disturbs the healthy balance of
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Turk, Seyhan. "The Impact of Biochemical Alterations in the Tumor Microenvironment on Cancer Progression and Treatment." In Current Researches in Health Sciences-II. Özgür Yayınları, 2023. http://dx.doi.org/10.58830/ozgur.pub128.c626.

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The tumor microenvironment (TME) plays a critical role in cancer progression and treatment response. Recent studies have revealed that biochemical alterations within the TME can significantly influence tumor behavior and therapeutic outcomes.&#x0D; Alterations in the TME, such as changes in pH, hypoxia, and nutrient availability, have been shown to promote cancer cell survival and growth. Acidic pH conditions within the TME enhance tumor invasiveness and metastasis while conferring resistance to conventional therapies. Hypoxia, caused by insufficient oxygen supply, not only promotes genetic in
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Conference papers on the topic "Acidic tumor microenvironment"

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Lekić, Milica, Mohammad Zoofaghari, Mladen Veletić, and Ilangko Balasingham. "Extracellular vesicle propagation in acidic tumor microenvironment." In NANOCOM '22: The Ninth Annual ACM International Conference on Nanoscale Computing and Communication. ACM, 2022. http://dx.doi.org/10.1145/3558583.3558843.

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Larijani, Nazanin Rohani, Traian Sulea, Mehdi Arbabi Ghahroudi, et al. "Abstract PO-049: Exploiting tumor acidic microenvironment for improved therapeutics." In Abstracts: AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; September 17-18, 2020. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.tumhet2020-po-049.

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Paralkar, Vishwas, Robert J. Aiello, Dan Marshall, et al. "Abstract 2981: Targeting solid tumor acidic microenvironment with an alphalex PARP inhibitor." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2981.

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Ding, Xinliang, Jason Miller, Ashley Campbell, Jonathan Almazan, Stephen Gutowski, and Tian Zhao. "Abstract 2867: Delivery of immunomodulators to the acidic tumor microenvironment by ultra-pH sensitive nanoparticle technology." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2867.

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Krewson, Elizabeth A., Li V. Yang, and Lixue Dong. "Abstract 1993: Acidic tumor microenvironment stimulation of GPR4 alters cytoskeletal dynamics and migration of vascular endothelial cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1993.

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Samykutty, Abhilash, Molly W. McNally, William E. Grizzle, Akiko Chiba, Alexandra Thomas, and Lacey R. McNally. "Abstract 4122: Acidic tumor microenvironment targeted wormhole-shaped mesoporous silica nanoparticles to detect ovarian cancer by multispectral optoacoustic tomography." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4122.

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Chen, Chong, Lipeng Bai, Fengqi Cao, et al. "Abstract 3546: LIN28B/MYC loop regulates aerobic glycolysis and tumor acidic microenvironment to promote cancer stemness and cancer progression." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3546.

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Brück, J., B. Klasen, N. Bausbacher, et al. "Strategies for PET Imaging in Acidic Tumor Microenvironments." In 61. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1766343.

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Popova, V. K., and E. V. Dmitrienko. "CALCIUM CARBONATE MATRICES FOR CONTROLLED DELIVERY OF NUCLEIC ACIDS AND THERAPEUTIC AGENTS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-341.

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If nanosized calcium carbonate is obtained the pH-dependent degradation profile of such compounds makes them promising candidates for selective drug delivery into the tumor microenvironment. Stable suspensions of calcium carbonate nanoparticles and their magnetic composites were obtained. The absence of toxicity of the compounds was proved, as well as their promising potential as transporters of small drug molecules and oligonucleotides.
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Wojtkowiak, Jonathan W., Natalie M. Barkey, Virendra Kumar, Mark C. Lloyd, Robert A. Gatenby, and Robert J. Gillies. "Abstract 1254: Altered lipid and glucose metabolism is a cellular adaptation to tumor acidic microenvironments." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1254.

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