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Journal articles on the topic 'Acidic tumor microenvironment'

Author: Grafiati

Published: 15 June 2024

Last updated: 19 July 2025

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1

Qu, Fanli, Guanwen Wang, Ningning Zhang, Qing Shao, and Xiaohua Zeng. "Abstract P3-02-29: The mechanism of acidic microenvironment promotes tumor-associated macrophages secreting glutamine to activate dual signaling pathways of mTORC1 and c-MYC in CDK4/6 inhibitor resistance of ER-positive breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–02–29—P3–02–29. https://doi.org/10.1158/1557-3265.sabcs24-p3-02-29.

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Abstract Resistance to CDK4/6 inhibitors in ER-positive breast cancer poses a clinical challenge, and the underlying mechanisms remain unclear. ER serves as a crucial regulator of glycolysis, promoting tumor progression and resistance by inducing microenvironmental acidification. We observed that an acidic microenvironment induces the polarization of tumor-associated macrophage (TAM) toward the M2 phenotype, leading to the secretion of glutamine. This activation of mTOR promotes resistance to CDK4/6 inhibitors in ER-positive breast cancer. Concurrently, glutamine promotes the upregulation of c

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Böhme, Ines, and Anja Katrin Bosserhoff. "Acidic tumor microenvironment in human melanoma." Pigment Cell & Melanoma Research 29, no. 5 (2016): 508–23. http://dx.doi.org/10.1111/pcmr.12495.

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Feng, Liangzhu, Ziliang Dong, Danlei Tao, Yicheng Zhang, and Zhuang Liu. "The acidic tumor microenvironment: a target for smart cancer nano-theranostics." National Science Review 5, no. 2 (2017): 269–86. http://dx.doi.org/10.1093/nsr/nwx062.

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Abstract The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in uti

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Liu, Yu-Cheng, Zhi-Xian Wang, Jing-Yi Pan, et al. "Recent Advances in Imaging Agents Anchored with pH (Low) Insertion Peptides for Cancer Theranostics." Molecules 28, no. 5 (2023): 2175. http://dx.doi.org/10.3390/molecules28052175.

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The acidic extracellular microenvironment has become an effective target for diagnosing and treating tumors. A pH (low) insertion peptide (pHLIP) is a kind of peptide that can spontaneously fold into a transmembrane helix in an acidic microenvironment, and then insert into and cross the cell membrane for material transfer. The characteristics of the acidic tumor microenvironment provide a new method for pH-targeted molecular imaging and tumor-targeted therapy. As research has increased, the role of pHLIP as an imaging agent carrier in the field of tumor theranostics has become increasingly pro

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Hasegawa, Manami, Keisuke Maede, Miyuki Nishida, et al. "Abstract 1511: Cancer adaptation to acidic tumor microenvironment." Cancer Research 85, no. 8_Supplement_1 (2025): 1511. https://doi.org/10.1158/1538-7445.am2025-1511.

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Cancer cells exhibit a characteristic metabolic pattern known as the Warburg effect, which upregulates glycolysis even in aerobic environments. As a result, cancer cells are exposed to an acidic environment due to enhanced excretion of proton and lactate. We have previously reported that this acidic tumor microenvironment induces the activation of the cholesterol biosynthesis pathway and the accumulation of N1-acetylspermidine. Although the acidic tumor microenvironment is known to suppress cancer cell proliferation, the survival strategies employed by cancer cells under such harsh conditions

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Jin, Haojie, Ning Wang, Cun Wang, and Wenxin Qin. "MicroRNAs in hypoxia and acidic tumor microenvironment." Chinese Science Bulletin 59, no. 19 (2014): 2223–31. http://dx.doi.org/10.1007/s11434-014-0273-y.

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Sharma, Vishal, та Jagdeep Kaur. "Acidic environment could modulate the interferon-γ expression: Implication on modulation of cancer and immune cells’ interactions". Asian Biomedicine 17, № 2 (2023): 72–83. http://dx.doi.org/10.2478/abm-2023-0047.

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Abstract Background In rapidly growing solid tumors, insufficient vascularization and poor oxygen supply result in an acidic tumor microenvironment, which can alter immune response. Objective To investigate the role of the acidic microenvironment in immune response modulation along with cancer and immune cells’ interactions. Method To mimic the tumor microenvironment conditions, T cells (Jurkat), macrophages (THP-1), and HeLa (cervical) cells were cultured under acidic conditions (pH 6.9, pH 6.5) and physiological pH (7.4). The HeLa cell culture medium was exploited as a tumor cell conditioned

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Boedtkjer, Ebbe, and Stine F. Pedersen. "The Acidic Tumor Microenvironment as a Driver of Cancer." Annual Review of Physiology 82, no. 1 (2020): 103–26. http://dx.doi.org/10.1146/annurev-physiol-021119-034627.

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Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH influence cancer and stromal cell function, their mutual interplay, and their interactions with the extracellular matrix. Tumor pH is spatially and temporally heterogeneous, and the fitness advantage of cancer cells adapted to extracellular acidity is likely particularly evident when they encounter less acidic tumor regions, for instance, during invasion. Throu

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Wayne Chang, Wun-Shaing. "Abstract B002: Dynamic response and evolving adaptation of pancreatic cancer cells to the prolonged acidic pH microenvironment." Cancer Research 84, no. 22_Supplement (2024): B002. http://dx.doi.org/10.1158/1538-7445.tumbody-b002.

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Abstract Solid tumor cells are often immersed in an acidic microenvironment. While many previous studies have investigated the short-term effects of extracellular acidity on tumor cells, little is known about how they adapt to the prolonged acidic microenvironmental stress and then advance to more aggressive stages. By challenging pancreatic tumor cells as an example with continuously and gradually acidified extracellular pH, a variety of cellular characteristics including phenotypic regulation, proliferation rates, autophagic control, metabolic plasticity and metastatic potentials were identi

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Kyriazi, Athina A., Makrina Karaglani, Sofia Agelaki, and Stavroula Baritaki. "Intratumoral Microbiome: Foe or Friend in Reshaping the Tumor Microenvironment Landscape?" Cells 13, no. 15 (2024): 1279. http://dx.doi.org/10.3390/cells13151279.

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The role of the microbiome in cancer and its crosstalk with the tumor microenvironment (TME) has been extensively studied and characterized. An emerging field in the cancer microbiome research is the concept of the intratumoral microbiome, which refers to the microbiome residing within the tumor. This microbiome primarily originates from the local microbiome of the tumor-bearing tissue or from translocating microbiome from distant sites, such as the gut. Despite the increasing number of studies on intratumoral microbiome, it remains unclear whether it is a driver or a bystander of oncogenesis

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Xu, Jingyong, Yao Li, Zhe Li, Weiwei Shao, Jinghai Song, and Junmin Wei. "Acidic Tumor Microenvironment Promotes Pancreatic Cancer through miR-451a/MEF2D Axis." Journal of Oncology 2022 (January 12, 2022): 1–12. http://dx.doi.org/10.1155/2022/3966386.

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Pancreatic cancer (PC), as a highly malignant and aggressive solid tumor, is common in the digestive system. The acidic microenvironment is one of the critical markers of cancer. Nonetheless, there are few studies on how the acidic microenvironment affects the development of PC. This study focused on investigating the specific molecular mechanisms of the acidic microenvironment in PC. In our study, qRT-PCR was conducted for examining microRNA (miR)-451a and myocyte enhancer factor 2D (MEF2D) expressions in PANC-1 cells. Then, detailed functional effects of an acidic environment on miR-451a and

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Noack, Anne-Kathrin, Henrike Lucas, Petr Chytil, Tomáš Etrych, Karsten Mäder, and Thomas Mueller. "Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment." International Journal of Molecular Sciences 21, no. 17 (2020): 6029. http://dx.doi.org/10.3390/ijms21176029.

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Stimulus-sensitive polymer drug conjugates based on high molecular weight N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers carrying doxorubicin via a pH-dependent cleavable bond (pHPMA-Dox) were previously shown to be able to overcome multi-drug resistance. Nevertheless, a tumor type dependent differential response was observed. Although an improved and more selective tumor accumulation of pHPMA-Dox is generally achieved due to the enhanced permeability and retention (EPR) effect, little is known about the fate of these conjugates upon entering the tumor tissue, which could explain the dif

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Chen, Chong, Peishan Hu, and Yufeng Chen. "Abstract 1356: The lactylation of SLC26A3 in acidic micro-environment contributes to colorectal carcinoma malignant progression." Cancer Research 85, no. 8_Supplement_1 (2025): 1356. https://doi.org/10.1158/1538-7445.am2025-1356.

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A recently discovered post-translational modification, lactylation, can regulate the structure and function of proteins, influencing cellular functions and disease progression. However, its role in tumor progression remains unclear.This study explored the contribution of lactylation modification of solute carrier family 26 member 3 (SLC26A3) in acidic microenvironments to the malignant progression of colorectal carcinoma (CRC). The findings revealed that the acidic tumor microenvironment reduced the stability and expression of SLC26A3 by promoting its lactylation. co-IP experiment results show

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Mbugua, Simon Ngigi. "Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy." Bioinorganic Chemistry and Applications 2022 (December 16, 2022): 1–20. http://dx.doi.org/10.1155/2022/5041399.

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photody

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Vernucci, Enza, Jaime Abrego, Venugopal Gunda, et al. "Metabolic Alterations in Pancreatic Cancer Progression." Cancers 12, no. 1 (2019): 2. http://dx.doi.org/10.3390/cancers12010002.

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Pancreatic cancer is the third leading cause of cancer-related deaths in the USA. Pancreatic tumors are characterized by enhanced glycolytic metabolism promoted by a hypoxic tumor microenvironment and a resultant acidic milieu. The metabolic reprogramming allows cancer cells to survive hostile microenvironments. Through the analysis of the principal metabolic pathways, we identified the specific metabolites that are altered during pancreatic cancer progression in the spontaneous progression (KPC) mouse model. Genetically engineered mice exhibited metabolic alterations during PanINs formation,

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Wu, Xiaomin, Boshi Wang, Yingjian Hou, et al. "PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer." Biomolecules 15, no. 3 (2025): 356. https://doi.org/10.3390/biom15030356.

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The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression and underlying mechanisms remain unclear. In this study, we examined ASIC1 expression in clinical liver tumor tissues using immunohistochemistry and immunofluorescence, correlating it with tumor stages. HepG2 and Li-7 cells were cultured in tumor supernatant and acidic conditions to mimic the tumor microenvironment. Western blotting assessed t

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Sheng, Liangju, Xuanlei Zhu, Miao Sun, et al. "Tumor Microenvironment-Responsive Magnetic Nanofluid for Enhanced Tumor MRI and Tumor multi-treatments." Pharmaceuticals 16, no. 2 (2023): 166. http://dx.doi.org/10.3390/ph16020166.

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We prepared a tumor microenvironment-responsive magnetic nanofluid (MNF) for improving tumor targeting, imaging and treatment simultaneously. For this purpose, we synthesized sulfonamide-based amphiphilic copolymers with a suitable pKa at 7.0; then, we utilized them to prepare the tumor microenvironment-responsive MNF by self-assembly of the sulfonamide-based amphiphilic copolymers and hydrophobic monodispersed Fe3O4 nanoparticles at approximately 8 nm. After a series of characterizations, the MNF showed excellent application potential due to the fact of its high stability under physiological

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He, Yongju, Xingyu Fan, Xiaozan Wu, et al. "pH-Responsive size-shrinkable mesoporous silica-based nanocarriers for improving tumor penetration and therapeutic efficacy." Nanoscale 14, no. 4 (2022): 1271–84. http://dx.doi.org/10.1039/d1nr07513f.

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To overcome the nanomedicine penetration barrier across the dense tumor matrix, acidic tumor microenvironment-responsive size-shrinkable mesoporous silica-based nanomedicine is developed for enhancing drug tumor penetration and therapeutic efficacy.

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Zhang, Lingling, Yang Song, Xiaoyan Dai, Wenwen Xu, Mengxia Li та Yuxi Zhu. "Inhibition of IDH3α Enhanced the Efficacy of Chemoimmunotherapy by Regulating Acidic Tumor Microenvironments". Cancers 15, № 6 (2023): 1802. http://dx.doi.org/10.3390/cancers15061802.

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In recent years, chemoimmunotherapy has become effective in some advanced cancers, but its effect is still limited. Transcriptional upregulation of isocitrate dehydrogenase 3α (IDH3α) can promote tumor initiation and progression. However, it is not clear whether the aberrant expression of IDH3α is related to the efficacy of chemoimmunotherapy in cancers. Here, we found that IDH3α was elevated in uterine cervical cancer (UCC) and lung adenocarcinoma (LUAD) samples by using public databases. High expression of IDH3α could promote the epithelial–mesenchymal transition (EMT), alter the intracellul

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Dharmaratne, Nayanthara U., Alanna R. Kaplan, and Peter M. Glazer. "Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides." Cells 10, no. 3 (2021): 541. http://dx.doi.org/10.3390/cells10030541.

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The delivery of cancer therapeutics can be limited by pharmacological issues such as poor bioavailability and high toxicity to healthy tissue. pH-low insertion peptides (pHLIPs) represent a promising tool to overcome these limitations. pHLIPs allow for the selective delivery of agents to tumors on the basis of pH, taking advantage of the acidity of the hypoxic tumor microenvironment. This review article highlights the various applications in which pHLIPs have been utilized for targeting and treating diseases in hypoxic environments, including delivery of small molecule inhibitors, toxins, nucl

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Sun, Xiao, Guilong Zhang, and Zhengyan Wu. "Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems." Current Medicinal Chemistry 25, no. 25 (2018): 3036–57. http://dx.doi.org/10.2174/0929867324666170406110642.

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According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc

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Wang, Joy X., Stephen Y. C. Choi, Xiaojia Niu, et al. "Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity." International Journal of Molecular Sciences 21, no. 21 (2020): 8363. http://dx.doi.org/10.3390/ijms21218363.

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Immune evasion and altered metabolism, where glucose utilization is diverted to increased lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has long been considered a waste product of this alteration, it is now well accepted that increased lactic acid production and the resultant acidification of the tumor microenvironment (TME) promotes multiple critical oncogenic processes including angiogenesis, tissue invasion/metastasis, and drug resistance. We and others have hypothesized that excess lactic acid in the TME is responsible for suppressing anticancer immu

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Wojtkowiak, Jonathan W., Daniel Verduzco, Karla J. Schramm, and Robert J. Gillies. "Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment." Molecular Pharmaceutics 8, no. 6 (2011): 2032–38. http://dx.doi.org/10.1021/mp200292c.

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Bhattacharya, Saswati, Jasmina Khanam, Pradipta Sarkar, and Tapan Kumar Pal. "A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics." RSC Advances 9, no. 1 (2019): 240–54. http://dx.doi.org/10.1039/c8ra08924h.

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Higashi, Sadayuki, Munekazu Yamakuchi, Hirohito Hashinokuchi та ін. "Adaptation to acidic conditions that mimic the tumor microenvironment, downregulates miR-193b-3p, and induces EMT via TGFβ2 in A549 cells". PLOS ONE 20, № 2 (2025): e0318811. https://doi.org/10.1371/journal.pone.0318811.

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The acidic tumor microenvironment plays a critical role in the malignant transformation of cancer cells. One mechanism underlying this transformation involves epithelial-mesenchymal transition (EMT). This is induced by prolonged exposure to acidic conditions. EMT is an essential process in cancer progression, with Transforming Growth Factor Beta (TGF-β) playing a central role in its induction. However, little was known about the factors regulating TGF-β under acidic conditions. This study aimed to elucidate the mechanism of EMT under acidic conditions and identify novel therapeutic targets to

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Sun, Yu, Zekun Wang, Pu Zhang, et al. "Mesoporous silica integrated with Fe3O4 and palmitoyl ascorbate as a new nano-Fenton reactor for amplified tumor oxidation therapy." Biomaterials Science 8, no. 24 (2020): 7154–65. http://dx.doi.org/10.1039/d0bm01738h.

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Lei, Yanli, Xiaoxiao He, Jinlu Tang, et al. "Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment." Chemical Communications 54, no. 73 (2018): 10288–91. http://dx.doi.org/10.1039/c8cc04420a.

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Reuss, Anna Maria, Dominik Groos, Michael Buchfelder, and Nicolai Savaskan. "The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant Glioma." International Journal of Molecular Sciences 22, no. 11 (2021): 5518. http://dx.doi.org/10.3390/ijms22115518.

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Malignant glioma represents a fatal disease with a poor prognosis and development of resistance mechanisms against conventional therapeutic approaches. The distinct tumor zones of this heterogeneous neoplasm develop their own microenvironment, in which subpopulations of cancer cells communicate. Adaptation to hypoxia in the center of the expanding tumor mass leads to the glycolytic and angiogenic switch, accompanied by upregulation of different glycolytic enzymes, transporters, and other metabolites. These processes render the tumor microenvironment more acidic, remodel the extracellular matri

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Walter, Sebastian Gottfried, Peter Knöll, Peer Eysel, et al. "Molecular In-Depth Characterization of Chondrosarcoma for Current and Future Targeted Therapies." Cancers 15, no. 9 (2023): 2556. http://dx.doi.org/10.3390/cancers15092556.

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Chondrosarcoma (CHS) are heterogenous, but as a whole, represent the second most common primary malignant bone tumor entity. Although knowledge on tumor biology has grown exponentially during the past few decades, surgical resection remains the gold standard for the treatment of these tumors, while radiation and differentiated chemotherapy do not result in sufficient cancer control. An in-depth molecular characterization of CHS reveals significant differences compared to tumors of epithelial origin. Genetically, CHS are heterogenous, but there is no characteristic mutation defining CHS, and ye

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Liu, Xiaodong, Qian Chen, Guangbao Yang, et al. "Magnetic nanomaterials with near-infrared pH-activatable fluorescence via iron-catalyzed AGET ATRP for tumor acidic microenvironment imaging." Journal of Materials Chemistry B 3, no. 14 (2015): 2786–800. http://dx.doi.org/10.1039/c5tb00070j.

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This work provides a fluorescent/magnetic iron oxide nanomaterials prototype to visualize the solid tumor in vivo by sensing the tumor acidic microenvironment, and a satisfactory tumor-to-normal tissue signal ratio (T/N ratio) and a prolonged time-window for 4T1 tumor visualization were observed in vivo.

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Wang, Heng, Beilei Wang, Jie Jiang, et al. "SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy." Molecules 27, no. 23 (2022): 8552. http://dx.doi.org/10.3390/molecules27238552.

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The acidic tumor microenvironment (TME) is unfriendly to the activity and function of immune cells in the TME. Here, we report inorganic nanozymes (i.e., SnSe NSs) that mimic the catalytic activity of lactate dehydrogenase to degrade lactate to pyruvate, contributing to the metabolic treatment of tumors. As found in this study, SnSe NSs successfully decreased lactate levels in cells and tumors, as well as reduced tumor acidity. This is associated with activation of the immune response of T cells, thus alleviating the immunosuppressive environment of the TME. More importantly, the nanozyme succ

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Xie, Yunong, Stephanie Ma, and Man Tong. "Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues." Cancers 14, no. 21 (2022): 5345. http://dx.doi.org/10.3390/cancers14215345.

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An increasing body of evidence suggests that cancer stem cells (CSCs) utilize reprogrammed metabolic strategies to adapt to a hostile tumor microenvironment (TME) for survival and stemness maintenance. Such a metabolic alteration in CSCs is facilitated by microenvironmental cues including metabolites such as glucose, amino acids and lipids, and environmental properties such as hypoxic and acidic TME. Similarly, metabolites uptake from the diet exerts critical imprints to the metabolism profile of CSCs and directly influence the maintenance of the CSC population. Moreover, CSCs interact with tu

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Andreucci, Elena, Silvia Peppicelli, Jessica Ruzzolini, et al. "The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells." Journal of Molecular Medicine 98, no. 10 (2020): 1431–46. http://dx.doi.org/10.1007/s00109-020-01959-y.

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Abstract Acidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both “aerobic” and “anaerobic” glycolysis of differently adapted cancer cells, with the final product lactic acid being responsible of the extracellular acidification. Many evidences underline the role of extracellular acidosis in tumor progression. Among the different findings, we demonstrated that acidosis-exposed cancer cells are characterized by an epithelial-to-mesenchymal transition phenotype with high invasive ability, high resistance to apoptosis,

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Zhan, Yuan, Mara Gonçalves, Panpan Yi, et al. "Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery." Journal of Materials Chemistry B 3, no. 20 (2015): 4221–30. http://dx.doi.org/10.1039/c5tb00468c.

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Doxorubicin is effectively loaded into disulfide-crosslinked poly(N-isopropylacrylamide-co-acrylic acid) nanogels, which can be triggerably released in a heating or reducing acidic tumor microenvironment.

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Palma, Susana I. C. J., Alexandra R. Fernandes, and Ana C. A. Roque. "An affinity triggered MRI nanoprobe for pH-dependent cell labeling." RSC Advances 6, no. 114 (2016): 113503–12. http://dx.doi.org/10.1039/c6ra17217b.

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The pH-sensitive affinity pair composed by neutravidin and iminobiotin was used to develop a multilayered Magnetic Resonance Imaging (MRI) nanoprobe responsive to the acidic pH of tumor microenvironment.

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Lv, Shuxin, Wei Long, Junchi Chen, et al. "Dual pH-triggered catalytic selective Mn clusters for cancer radiosensitization and radioprotection." Nanoscale 12, no. 2 (2020): 548–57. http://dx.doi.org/10.1039/c9nr08192e.

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Mn clusters with pH-triggered catalytic selective capacity could optimize the effects of radiotherapy in the acidic tumor microenvironment, while protecting normal tissues from radiation in neutral circumstances simultaneously.

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Peppicelli, Silvia, Elena Andreucci, Jessica Ruzzolini, et al. "The acidic microenvironment as a possible niche of dormant tumor cells." Cellular and Molecular Life Sciences 74, no. 15 (2017): 2761–71. http://dx.doi.org/10.1007/s00018-017-2496-y.

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Shen, Ming, Yongzhuo Huang, Limei Han, et al. "Multifunctional drug delivery system for targeting tumor and its acidic microenvironment." Journal of Controlled Release 161, no. 3 (2012): 884–92. http://dx.doi.org/10.1016/j.jconrel.2012.05.013.

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Choi, Joung-Woo, Soo-Jung Jung, Dayananda Kasala, et al. "pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis." Journal of Controlled Release 205 (May 2015): 134–43. http://dx.doi.org/10.1016/j.jconrel.2015.01.005.

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Zhang, Bingyu, Xue Zhang, Xianxin Wen, and Dui Qin. "Construction of a three-dimensional culture system based on Gelatin methacryloyl hydrogel for lung cancer cells." Journal of Physics: Conference Series 2783, no. 1 (2024): 012061. http://dx.doi.org/10.1088/1742-6596/2783/1/012061.

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Abstract Hypoxia and acidity are key characteristics of the tumor microenvironment (TME). Gelatin methacryloyl (GelMA) is a versatile biomaterial extensively utilized in various biomedical fields. Studies have shown that during the photocrosslinking process of GelMA hydrogel, the commonly used photoinitiator Irgacure 2959 consumes oxygen and induces an acidic and hypoxia environment. However, there is currently limited research on its involvement in the three-dimensional (3D) culture of tumor cells. Therefore, we constructed a 3D culture system utilizing GelMA hydrogel and investigated its inf

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Voss, Ninna C. S., Thomas Dreyer, Mikkel B. Henningsen, Pernille Vahl, Bent Honoré, and Ebbe Boedtkjer. "Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue." Cancers 12, no. 4 (2020): 891. http://dx.doi.org/10.3390/cancers12040891.

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The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinking water to female C57BL/6j mice. We evaluate urine and blood acid-base status, tumor metabolism (microdialysis sampling), and tumor pH (pH-sensitive microelectrodes) in vivo. Based on freshly isolated epithelial organoids from breast carcinomas and normal breast tissue, we assess protein expression (immunoblotting, mass spectrometry), intracellular

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Clark, Amelia M., and Brian J. Altman. "Circadian control of macrophages in the tumor microenvironment." Journal of Immunology 208, no. 1_Supplement (2022): 165.06. http://dx.doi.org/10.4049/jimmunol.208.supp.165.06.

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Abstract Introduction All leukocytes tested to date have functional circadian clocks, and nearly every arm of the immune response is subject to circadian regulation. Circadian clocks instruct the time-of-day-dependent, rhythmic expression of genes in a tissue- and cell-specific manner. In macrophages (mΦs), the circadian clock regulates several factors that are critical to executing effective immune responses. Tumor-associated mΦs are major contributors to immune suppression in the tumor microenvironment (TME). Evidence suggests that metabolically stressful factors in the TME such as acidic pH

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Si, Zhan, Cuiyun Huang, Xihui Gao, and Cong Li. "pH-responsive near-infrared nanoprobe imaging metastases by sensing acidic microenvironment." RSC Adv. 4, no. 98 (2014): 55548–55. http://dx.doi.org/10.1039/c4ra07984a.

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A pH responsive near-infrared fluorescence nanoprobe was developed and visualized pulmonary metastases in a mouse model with a volume as small as 0.5 mm<sup>3</sup> by sensing the acidic tumor microenvironment.

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Wang, Sheng, Jiaji Mao, Hong Liu, et al. "pH-Sensitive nanotheranostics for dual-modality imaging guided nanoenzyme catalysis therapy and phototherapy." Journal of Materials Chemistry B 8, no. 22 (2020): 4859–69. http://dx.doi.org/10.1039/c9tb02731a.

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A theranostic nanosystem with a pH-sensitive structure showed charge conversion properties in the tumor acidic microenvironment. It could perform dual-modality imaging diagnosis and carry out catalysis therapy and phototherapy.

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Shiba, Hiroya, Misaki Nishio, Mei Sawada, et al. "Carboxy-terminal dendrimers with phenylalanine for a pH-sensitive delivery system into immune cells including T cells." Journal of Materials Chemistry B 10, no. 14 (2022): 2463–70. http://dx.doi.org/10.1039/d1tb01980e.

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Dendrimers with phenylalanine (Phe) and cyclohexanedicarboxylic acid (CHex) showed higher uptake into various cells including T cells via endocytosis. The cell association was enhanced under weak acidic conditions observed in tumor microenvironment.

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Qi, Guohua, Bo Wang, Xiangfu Song, Haijuan Li, and Yongdong Jin. "A green, efficient and precise hydrogen therapy of cancer based on in vivo electrochemistry." National Science Review 7, no. 3 (2019): 660–70. http://dx.doi.org/10.1093/nsr/nwz199.

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Abstract By combined use of traditional Chinese acupuncture Fe needle electrode and in vivo electrochemistry, we achieved in vivo H2 generation in tumors in a controllable manner and exploited it for effective and green therapy of tumors for the first time. The cathodic acupuncture electrodes working under an applied voltage of ∼3 V (with minimal damage to the living body) undergo effective electrochemical reactions in the acidic tumor area that produce sufficient H2 locally to cause cancer cells to burst and die. Due to puncture positioning, the acidic tumor microenvironment and gas diffusion

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Tsai, Ming-Hsien, Cheng-Liang Peng, Cheng-Jung Yao, and Ming-Jium Shieh. "Enhanced efficacy of chemotherapeutic drugs against colorectal cancer using ligand-decorated self-breakable agents." RSC Advances 5, no. 112 (2015): 92361–70. http://dx.doi.org/10.1039/c5ra16175d.

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Targeting self-breakable micelles could facilitate Caco2 cancer cells in acidic tumor microenvironment to take up SN38 which the micelle loaded with and trigger drug release in cancer cells, resulting in enhanced drug efficacy.

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Yoneda, Toshiyuki N/A, Masahiro N/A Hiasa, Yuki N/A Nagata, Matthew S. Ripsch, Fletcher A. White, and G. David Roodman. "Acidic Extracellular Microenvironment in Myeloma-Colonized Bone Contributes to Bone Pain." Blood 124, no. 21 (2014): 3397. http://dx.doi.org/10.1182/blood.v124.21.3397.3397.

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Abstract Multiple myeloma (MM) bone disease results in devastating bone pain and fractures, which are the major cause of morbidity, and contribute to increased mortality and diminish the quality of life in MM patients. Current treatments for MM bone pain do not completely control the pain and have serious side effects. Thus, new therapies are needed to control myeloma bone pain. However, the mechanisms responsible for MM-associated bone pain are poorly understood. Specific osteoclast inhibitors (bisphosphonates and denosumab) can reduce bone pain in MM patients, suggesting that factors release

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Bogdanov, A. A., An A. Bogdanov, and V. M. Moiseyenko. "Alkalinization of the tumor microenvironment: are there prospects as a therapeutic objective?" Practical oncology 23, no. 3 (2022): 143–59. http://dx.doi.org/10.31917/2303143.

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Tumor acidity is one of the hallmarks of cancer. The use of glycolysis as the main source of ATP production due to the metabolic reprogramming of cancer cells makes their intracellular pH alkaline and extracellular pH acidic. This metabolic reprogramming and acidification are part of the general defenses that allow malignant cells to survive, multiply, spread, and become resistant to therapies. Tumor acidity may also be associated with a poor prognosis for cancer patients, and clinicians should consider this when diagnosing and determining optimal treatment. On the other hand, the inversion of

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Nam, Jeong-Seok, Choong-Jae Lee, and Hyeon-Ji Yun. "Abstract 5111: Targeting the dysadherin/CA9 axis inhibits colorectal cancer adaptation and growth within the acidic tumor microenvironment." Cancer Research 85, no. 8_Supplement_1 (2025): 5111. https://doi.org/10.1158/1538-7445.am2025-5111.

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Abstract The tumor microenvironment (TME) has a significant impact on colorectal cancer (CRC) progression by promoting tumor survival and aggressive behavior. A key player in this process is the tumor-associated glycoprotein dysadherin, which is highly expressed in aggressive CRC cells and facilitates their adaptation to the TME. In this study, we conducted a comprehensive bioinformatics analysis of clinical genomic data from CRC patients, integrated with studies on dysadherin-knockout CRC cells. We also examined the downstream effects of dysadherin in human CRC cells, patient tissue samples,

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