Academic literature on the topic 'Ageing Clock'

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Journal articles on the topic "Ageing Clock"

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Guevara, Elaine E., Richard R. Lawler, Nicky Staes, et al. "Age-associated epigenetic change in chimpanzees and humans." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1811 (2020): 20190616. http://dx.doi.org/10.1098/rstb.2019.0616.

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Methylation levels have been shown to change with age at sites across the human genome. Change at some of these sites is so consistent across individuals that it can be used as an ‘epigenetic clock’ to predict an individual's chronological age to within a few years. Here, we examined how the pattern of epigenetic ageing in chimpanzees compares with humans. We profiled genome-wide blood methylation levels by microarray for 113 samples from 83 chimpanzees aged 1–58 years (26 chimpanzees were sampled at multiple ages during their lifespan). Many sites (greater than 65 000) showed significant chan
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O’Brien, Yvonne, and Mary B. Wingfield. "Reproductive ageing—turning back the clock?" Irish Journal of Medical Science (1971 -) 188, no. 1 (2018): 161–67. http://dx.doi.org/10.1007/s11845-018-1769-2.

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Gibbs, W. Wayt. "Biomarkers and ageing: The clock-watcher." Nature 508, no. 7495 (2014): 168–70. http://dx.doi.org/10.1038/508168a.

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AGRELL, BERIT, and OVE DEHLIN. "The clock-drawing test." Age and Ageing 27, no. 3 (1998): 399–403. http://dx.doi.org/10.1093/ageing/27.3.399.

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Agrell, B., and O. Dehlin. "The clock-drawing test." Age and Ageing 41, suppl 3 (2012): iii41—iii45. http://dx.doi.org/10.1093/ageing/afs149.

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Halmos, Tamás, and Ilona Suba. "Physiological and pathophysiological role of the circadian clock system." Orvosi Hetilap 153, no. 35 (2012): 1370–79. http://dx.doi.org/10.1556/oh.2012.29436.

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It has been well known for ages that in living organisms the rhythmicity of biological processes is linked to the ~ 24-hour light–dark cycle. However, the exact function of the circadian clock system has been explored only in the past decades. It came to light that the photosensitive primary “master clock” is situated in the suprachiasmatic photosensitive nuclei of the special hypothalamic region, and that it is working according to ~24-hour changes of light and darkness. The master clock sends its messages to the peripheral “slave clocks”. In many organs, like pancreatic β-cells, the slave cl
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El-Houni, Zeyad, Alexander Eckersley, Mike Bell, et al. "P12 Tetrapeptide matrikines synchronize circadian rhythms and promote proliferation in human skin cells." British Journal of Dermatology 189, no. 1 (2023): e18-e18. http://dx.doi.org/10.1093/bjd/ljad174.033.

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Abstract Circadian rhythms are intrinsically generated 24 h rhythms that play a vital role in enabling the skin to adapt temporally to various external stimuli. These include ultraviolet radiation, physical trauma and water loss. At the molecular level, circadian clocks consist of various clock genes and proteins, including Per2/Cry1 and Bmal1/Clock, forming autoregulatory feedback loops. Although these rhythms are known to be impaired in ageing skin, there are limited therapeutic options to restore skin cell circadian function. As small peptides with homology to amino acid sequences found in
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Raj, Kenneth, and Steve Horvath. "Current perspectives on the cellular and molecular features of epigenetic ageing." Experimental Biology and Medicine 245, no. 17 (2020): 1532–42. http://dx.doi.org/10.1177/1535370220918329.

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It has been noted for quite some time that DNA methylation levels decline with age. The significance of this change remained unknown until it became possible to measure methylation status of specific sites on the DNA. It was observed that while the methylation of some sites does indeed decrease with age, that of others increase or remain unchanged. The application of machine learning methods to these quantitative changes in multiple sites, allowed the generation of a highly accurate estimator of age, called the epigenetic clock. The application of this clock on large human epidemiological data
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FRIEDMAN, PAUL J. "Clock Drawing in Acute Stroke." Age and Ageing 20, no. 2 (1991): 140–45. http://dx.doi.org/10.1093/ageing/20.2.140.

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Liu, Zuyun, and Yimin Zhu. "Epigenetic clock: a promising mirror of ageing." Lancet Healthy Longevity 2, no. 6 (2021): e304-e305. http://dx.doi.org/10.1016/s2666-7568(21)00098-2.

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Dissertations / Theses on the topic "Ageing Clock"

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Curran, Jack. "Ageing and the Drosophila circadian clock." Thesis, University of Bristol, 2019. http://hdl.handle.net/1983/7b02ec7c-f6a2-4640-b50f-ce97a66a5a11.

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It is well established that elderly individuals have increased difficulty sleeping at night combined with falling asleep and waking up earlier. Although these age-related declines in circadian output are clearly observable in activity recordings of laboratory animals, the underlying changes in molecular and neuronal activity remain unknown. The fruit fly, Drosophila melanogaster, has long been used as a model for studying the circadian system and for ageing research. In this thesis Drosophila was used as a model to study the effect of ageing on circadian and sleep behaviour. Circadian behaviou
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Xia, Yao. "Artificial intelligence-assisted prediction, feature selection, and multi-omics integration in exploring the interaction between IgG N-glycome and transcriptome and constructing the ageing clock." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2023. https://ro.ecu.edu.au/theses/2646.

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Liu, Taole. "La peau, un modèle d'horloge périphérique." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ007/document.

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Ce travail avait pour objet d’étudier les propriétés d’horloge et de synchronisation de la peau, un modèle potentiel d’horloge périphérique. L’activité rythmique a été analysée par bioluminescence en temps réel, sur des explants de peau abdominale et des fibroblastes dermiques primaires, isolés à partir de rats transgéniques Per1-luciférase. Nous avons montré que des explants de peau présentent une activité rythmique soutenue en culture, indiquant une importante synchronisation interne dans le tissu. Cette synchronisation se manifeste au cours du développement post-natal à partir de 1 mois et
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Lovisari, Enrico. "Synchronization algorithms for multi-agent systems: Analysis, Synthesis and Applications." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422115.

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The main topic of this thesis is the study of the interaction of agents interconnected in a large-scale network. In the thesis, three complementary problems have been afforded: Analysis of Consensus Networks, Synthesis of Higher Order Consensus Networks, and Application of Synchronization algorithms<br>Questa tesi di dottorato e incentrata sullo studio dell'interazione di agenti interconnessi in rete. In questa tesi vengono affrontati tre problemi complementari l'un l'altro: Analisi di reti di consenso, Sintesi di reti di consenso di ordine superiore, e Applicazione di algoritmi di sincronizza
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Diop, Bocar Noël. "Élaboration de nanoparticules hybrides multifonctionnelles à base de silice par microémulsion inverse : application à la conception d’un agent antibactérien." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10281/document.

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Cette thèse a pour objectif l’élaboration de nanoparticules hybrides à base de silice par microémulsion inverse. Les nanoparticules de silice constituent une matrice de base permettant de confiner et de protéger des molécules organiques et/ou des nanoparticules métalliques. L’incorporation combinée de différentes entités dans la silice ouvre ainsi de larges perspectives de par l'introduction de nouvelles propriétés liées à la structure hybride. Afin d’élaborer de tels objets, nous avons utilisé des micelles inverses à base d'eau, de Triton X-100, d'hexanol et de cyclohexane comme milieu réacti
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Chen, Weixuan. "Development of Antimicrobial Agent with Novel Mechanisms of Actions and 1,2,4,5-Tetrazine Click Chemistry and its Application in DNA Postsynthetic Functionalization." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/chemistry_diss/72.

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SecA ATPase is a critical member of the Sec system, which is important in the translocation of membrane and secreted polypeptides/proteins in bacteria. Small molecule inhibitors can be very useful research tools as well as leads for future antimicrobial agent development. Based on previous virtual screening work, we optimized the structures of two hit compounds and obtained SecA ATPase inhibitors with IC50 in the single digit micromolar range. These represent the first low micromolar inhibitors of bacterial SecA and will be very useful for mechanistic studies. Post synthetic modification is an
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Diop, Bocar Noël. "Élaboration de nanoparticules hybrides multifonctionnelles à base de silice par microémulsion inverse : application à la conception d'un agent antibactérien." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00838729.

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Cette thèse a pour objectif l'élaboration de nanoparticules hybrides à base de silice par microémulsion inverse. Les nanoparticules de silice constituent une matrice de base permettant de confiner et de protéger des molécules organiques et/ou des nanoparticules métalliques. L'incorporation combinée de différentes entités dans la silice ouvre ainsi de larges perspectives de par l'introduction de nouvelles propriétés liées à la structure hybride. Afin d'élaborer de tels objets, nous avons utilisé des micelles inverses à base d'eau, de Triton X-100, d'hexanol et de cyclohexane comme milieu réacti
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Kružliak, Miroslav. "Inteligentní agenti v bezdrátových sítích." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2010. http://www.nusl.cz/ntk/nusl-237181.

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This Master thesis deals with synchronization of sensor nodes in wireless sensor net. It is used event ordering by the implementation of logical clocks . Lamport's algorithm is used here for synchronization, which is trying to order events within the given system. The thesis also evaluates how appropriate this principle for synchronization is. The implementation has been carried out in agent-oriented language AgentSpeak on the Jason platform. Samson environment has been used and modified for observation of this synchronization's behaviour and testing purposes.
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Duro, Diana Filipa Dias. "The Clock Drawing Test in the detection of cognitive impairment: Validation studies for the Portuguese population." Doctoral thesis, 2021. http://hdl.handle.net/10316/95335.

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Tese de Doutoramento no âmbito do Programa Doutoral Interuniversitário em Envelhecimento e Doenças Crónicas, apresentada à Faculdade de Medicina da Universidade de Coimbra.<br>The Clock Drawing Test (CDT) is a popular neuropsychological instrument for the identification of cognitive decline, particularly Alzheimer’s disease (AD). The use of this test lacked specific validation studies for the Portuguese population, and that was the purpose of this project. The CDT showed good psychometric properties in all parameters assessed. The three selected scoring systems (Rouleau, Cahn and Babins) pres
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Neumann, Adam. "Analiza ekspresji genów zegara biologicznego w męskim układzie rozrodczym ssaków." Doctoral thesis, 2016. https://depotuw.ceon.pl/handle/item/1700.

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Funkcjonowanie centralnego zegara biologicznego ssaków jest dobrze udokumentowane. Przedmiotem dyskusji pozostaje jednak istnienie tego mechanizmu w narządach męskiego układu rozrodczego. Rytmiczna ekspresja genów oscylatora molekularnego (Per1, Per2, Cry1, Cry2, Bmal1, Clock) i cykliczne zmiany poziomu kodowanych przez nie białek stanowią jedno z podstawowych kryteriów wykorzystywanych do identyfikacji zegarów peryferycznych u zwierząt. Dodatkowo przypuszczać należy, że oscylator molekularny, potencjalnie zlokalizowany w narządach męskiego układu rozrodczego może regulować procesy fizjologicz
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Books on the topic "Ageing Clock"

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Haptonstall, Paola. Secret Anti Ageing Life Hacks : Stop the Clock and Live a Longer, Healthier: Anti Aging Method. Independently Published, 2021.

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Race Against The Clock Secret Agent Activity Book. Dover Publications, 2011.

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MacInnes, Helen. Mystery: Agent in Place, the Hidden Target, Cloak of Darkness. BBS Publishing Corporation, 1996.

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MacInnes, Helen. Helen Macinnes: Three Bestselling Novels of Terror & Espionage : Agent in Place : The Hidden Target : Cloak of Darkness. BBS Publishing Corporation, 1993.

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Cooley's Anemia Symposium 2005 Lake Buen, Elliott P. Vichinsky, Stromboli Conference on Aging And Cancer, and Walter Pierpaoli. Reversal of Aging-Myth and Reality: Beyond the Man Made Barriers (Annals of the New York Academy of Sciences). New York Academy of Sciences, 2006.

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Watson, J. Francis. The Nazi Spy Pastor. ABC-CLIO, LLC, 2014. http://dx.doi.org/10.5040/9798400690327.

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One man could have enabled the most audacious terrorist threat against America prior to 9/11 and helped the Nazis win World War II—the Nazi spy pastor, Carl Krepper. His riveting story brings to light a forgotten chapter in the history of the Second World War. As America continues to wrestle with issues surrounding the threat of sabotage and terrorism, this eye-opening work details a very real threat faced by our country in the Second World War, and the key aspects of the underground war that was fought in this country by Nazi agents. The Nazi Spy Pastor: Carl Krepper and the War in America pr
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Book chapters on the topic "Ageing Clock"

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Judge, Michael, James Griffith, and Jonathan Arnold. "Aging and the Biological Clock." In Healthy Ageing and Longevity. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64543-8_10.

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Jagota, Anita, and Neelesh Babu Thummadi. "Hormones in Clock Regulation During Ageing." In Healthy Ageing and Longevity. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63001-4_11.

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Rizvi, Syed Ibrahim, and Gaurav Majumdar. "Circadian System and Ageing in Rodent Models." In Circadian Clock and Aging. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-6695-6_4.

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Vaiserman, Alexander, and Oleh Lushchak. "Early-Life Adjustment of Epigenetic Aging Clock." In Healthy Ageing and Longevity. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24958-8_14.

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Miyazaki, Shota, Wataru Nakamura, and Takahiro J. Nakamura. "Age-Related Decline in the Central Circadian Clock." In Healthy Ageing and Longevity. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22468-3_4.

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Rizvi, Syed Ibrahim, and Gaurav Majumdar. "The Circadian Clock as a Drug Target for Anti-Ageing Strategies." In Circadian Clock and Aging. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-6695-6_8.

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Jagota, Anita. "Sleep and Circadian Clock: Novel Players in Health Impacts and Aging." In Healthy Ageing and Longevity. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22468-3_1.

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Jagota, Anita, Zeeshan Akhtar Khan, Sushree Abhidhatri Sharma, and Minurani Dalai. "Yogic Interventions in Clock Dysfunction, Neurodegeneration and Ageing." In Neuroscience of Yoga. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-2855-8_4.

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Galkute, Milda, Luis Rojas, and Erick Folch. "Life Clock: Developing a Technological Platform to Promote Active Ageing." In Social Computing and Social Media: Applications in Marketing, Learning, and Health. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-77685-5_26.

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Gupta, Richa, and Roman V. Kondratov. "Circadian Clocks and mTOR Signaling." In Healthy Ageing and Longevity. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64543-8_9.

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Conference papers on the topic "Ageing Clock"

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de Vries, M., M. E. Martinus, N. J. Bekker, et al. "Epigenetic clock analysis shows accelerated ageing in severe early onset COPD." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.4574.

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Bolognani, Saverio, Ruggero Carli, Enrico Lovisari, and Sandro Zampieri. "A randomized linear algorithm for clock synchronization in multi-agent systems." In 2012 IEEE 51st Annual Conference on Decision and Control (CDC). IEEE, 2012. http://dx.doi.org/10.1109/cdc.2012.6426232.

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Lamperski, Andrew, and Antonis Papachristodoulou. "Stability and consensus for multi-agent systems with Poisson clock noise." In 2014 IEEE 53rd Annual Conference on Decision and Control (CDC). IEEE, 2014. http://dx.doi.org/10.1109/cdc.2014.7039854.

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Saputra, Komang Oka, Wei-Chung Teng, and Yi-Hao Chu. "A Clock Skew Replication Attack Detection Approach Utilizing the Resolution of System Time." In 2015 IEEE / WIC / ACM International Conference on Web Intelligence and Intelligent Agent Technology (WI-IAT). IEEE, 2015. http://dx.doi.org/10.1109/wi-iat.2015.10.

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Zhuang, Ziming, Cliff Brunk, Prasenjit Mitra, and C. Lee Giles. "Towards Click-Based Models of Geographic Interests in Web Search." In 2008 IEEE/WIC/ACM International Conference on Web Intelligence and Intelligent Agent Technology. IEEE, 2008. http://dx.doi.org/10.1109/wiiat.2008.365.

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Korniienko, A., G. Scorletti, E. Colinet, E. Blanco, J. Juillard, and D. Galayko. "Control law synthesis for distributed multi-agent systems: Application to active clock distribution networks." In 2011 American Control Conference. IEEE, 2011. http://dx.doi.org/10.1109/acc.2011.5991295.

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Jadue, Joaquin, Gino Slanzi, Luis Salas, and Juan D. Velasquez. "Web User Click Intention Prediction by Using Pupil Dilation Analysis." In 2015 IEEE / WIC / ACM International Conference on Web Intelligence and Intelligent Agent Technology (WI-IAT). IEEE, 2015. http://dx.doi.org/10.1109/wi-iat.2015.221.

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Guo, Qi, Eugene Agichtein, Charles L. A. Clarke, and Azin Ashkan. "In the Mood to Click? Towards Inferring Receptiveness to Search Advertising." In 2009 IEEE/WIC/ACM International Joint Conference on Web Intelligence and Intelligent Agent Technology. IEEE, 2009. http://dx.doi.org/10.1109/wi-iat.2009.368.

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Resneau, P., N. von Bandel, M. Garcia, et al. "Long time ageing tests of DFB ridge laser diodes emitting at 852nm and 894nm for cesium atomic clocks." In SPIE OPTO, edited by Manijeh Razeghi. SPIE, 2017. http://dx.doi.org/10.1117/12.2252608.

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Katariya, Sumeet, Branislav Kveton, Csaba Szepesvári, Claire Vernade, and Zheng Wen. "Bernoulli Rank-1 Bandits for Click Feedback." In Twenty-Sixth International Joint Conference on Artificial Intelligence. International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/278.

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The probability that a user will click a search result depends both on its relevance and its position on the results page. The position based model explains this behavior by ascribing to every item an attraction probability, and to every position an examination probability. To be clicked, a result must be both attractive and examined. The probabilities of an item-position pair being clicked thus form the entries of a rank-1 matrix. We propose the learning problem of a Bernoulli rank-1 bandit where at each step, the learning agent chooses a pair of row and column arms, and receives the product
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Reports on the topic "Ageing Clock"

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Chen, Guang. Multi-agent Collaborative Perception for Autonomous Driving: Unsettled Aspects. SAE International, 2023. http://dx.doi.org/10.4271/epr2023017.

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&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;This report delves into the field of multi-agent collaborative perception (MCP) for autonomous driving: an area that remains unresolved. Current single-agent perception systems suffer from limitations, such as occlusion and sparse sensor observation at a far distance.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;&lt;b&gt;Multi-agent Collaborative Perception for Autonomous Driving: Unsettled Aspects&lt;/b&gt; addresses three unsettled topics that demand immediate attention: &lt;ul class="list disc"&gt;&lt;li class="li
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Doo, Johnny. The Use of eVTOL Aircraft for First Responder, Police, and Medical Transport Applications. SAE International, 2023. http://dx.doi.org/10.4271/epr2023020.

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&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Advancements in electric vertical takeoff and landing (eVTOL) aircraft have generated significant interest within and beyond the traditional aviation industry. One particularly promising application involves on-demand, rapid-response use cases to broaden first responders, police, and medical transport mission capabilities. With the dynamic and varying public service operations, eVTOL aircraft can offer potentially cost-effective aerial mobility components to the overall solution, including significant lifesaving benefits
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