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Dissertations / Theses on the topic 'Airway'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Williams, Adele. "Polymeric airway mucins in equine recurrent airway obstruction." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/polymeric-airway-mucins-in-equine-recurrent-airway-obstruction(14c6bee5-5406-4b7a-a9b5-495443c7c635).html.

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In healthy airways, mucus forms part of the innate immune response protecting the respiratory epithelium from damage by pathogens and environmental debris (Rose and Voynow, 2006). Conversely, in many respiratory diseases, mucus becomes part of the airway disease pathology. Mucus hypersecretion along with reduced clearance can cause blockage of the small airways, impairing gas exchange, promoting inflammation and becoming a culture medium for bacterial colonisation (Thornton et al., 2008). Recurrent airway obstruction (RAO) is a common yet poorly understood equine chronic respiratory disease wh
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2

Zhao, Jingyue. "Th17 responses in airway inflammation and airway remodelling." Thesis, King's College London (University of London), 2011. http://kclpure.kcl.ac.uk/portal/en/theses/th17-responses-in-airway-inflammation-and-airway-remodelling(94ca2e63-6304-4694-998e-b40747ca0f9a).html.

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3

Shebani, Eyman. "Ultrastructural Studies of the Airway Epithelium in Airway Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6632.

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4

Hamilton, Nicholas J. I. "Tissue-engineering airway mucosa for airway reconstruction and transplantation." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/1572383/.

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Conventional therapies are unable to treat a subset of patients with upper airway stenosis. To overcome this, tissue-engineered tracheas have been trialled as a means of replacing the damaged section of airway. All examples have suffered from poor mucosalisation following implantation which results in infection, mucostasis and airway obstruction. The aim of this thesis was to investigate methods of regenerating a respiratory mucosal graft that could be used as part of a tracheal transplant. The relationship of the extracellular matrix to human respiratory epithelial cells (HBECs) was examined
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5

Korpela, Antti. "Healing of airway anastomoses and stenting of airway stenosis." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/korpela/.

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6

Tao, Florence C. Y. "Mechanisms of altered airway smooth muscle calcium signalling in airway hyperresponsiveness." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0022/NQ50267.pdf.

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7

Tao, Florence C. Y. 1968. "Mechanisms of altered airway smooth muscle calcium signalling in airway hyperresponsiveness." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35949.

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The pathophysiological origins of airway hyperresponsiveness (AHR) in asthma are unknown. The objectives of this thesis were to establish an association between AHR in an animal model of asthma and altered contractility of airway smooth muscle (ASM) and to elucidate changes in contractile signalling that could account for any observed differences in ASM contractility. The Fisher strain of rat is spontaneously hyperresponsive to methacholine inhalation challenge relative to Lewis rats. These inbred rat strains provide a model with which to study genetically-determined variations in airway smoot
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8

Kölbeck, Karl-Gustav. "Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-428-3/.

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9

Opazo, Saez Anabelle M. (Anabelle Marjorie). "Airway responsiveness to methacholine and airway smooth muscle in the guinea pig." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60629.

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The purpose of this study was two-fold: (1) to examine the relationship between the amount of airway smooth muscle and the airway responsiveness to inhaled aerosolized methacholine (MCh) in guinea pigs, and (2) to characterize the distribution of airway narrowing following MCh.<br>In summary: (1) the quantity of airway smooth muscle (ASM) does not appear to determine differences in maximal bronchoconstriction among normal guinea pigs; the lack of a correlation between responsiveness and amount of ASM may be explained by the heterogenous distribution of bronchoconstriction among the airways stu
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10

Wang, Jiahua. "The role of airway epithelium in airway inflammation and effect of corticosteroids." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300175.

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11

Yu, Chia-Chen S. M. Massachusetts Institute of Technology. "A microfluidic mucosal airway model to study airway mucosal function and pathogenesis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107373.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 64-67).<br>Airway mucus hypersecretion or impaired clearance is one of the key pathophysiological features of airborne infection, allergy and severe respiratory diseases. As foreign particles enter the lungs, the airway becomes inflamed and excessive amount of mucus is generated in response. However, little is known about the role of mucus in regulating the passage of potentially harmful part
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12

Daud, Tariq. "The role of WNT5a in airway remodelling in asthmatic airway epithelial repair." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42778.

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Asthma is heterogeneous disease characterised by distinct tissue molecular phenotypes (Choy et al, 2015). However, the process of repair and remodelling remains ambiguous in this context. Although previous reports have shown elevated protein and mRNA expression of WNT5a, there is limited evidence in the literature to the major source of and function of WNT5a in asthma. Furthermore, WNT5a acting through the non-canonical axis exhibits functional cross talk with TGF-β1, which may influence repair and remodelling in asthma. We sought to evaluate protein expression of WNT5a and TGF-β1 in bronchial
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13

Noble, Peter Beresford. "Regulation of airway narrowing by dynamic and static mechanical loads." University of Western Australia. School of Biomedical and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0050.

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[Truncated abstract] The extent to which an airway narrows is strongly influenced by mechanical loads on airway smooth muscle (ASM). This thesis considers both dynamic and static mechanical loads. Dynamic load describes the time varying load on airways produced by oscillatory breathing movements. Static load is that present at a fixed lung volume ie. without breathing. In the intact lung static load principally comprises the pressure across the airway wall, that is transmural pressure (Ptm), and elastic after-load arising from distortion of airway and lung tissue by the narrowing airway. The e
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14

Tiklová, Katarína. "Airway maturation in Drosophila." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62419.

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Tubes are a fundamental unit of organ design. Most of our major organs like the lung, kidney and vasculature are composed primarily of tubes. To identify fundamental biological principles of tubular organ formation we used the respiratory organ of Drosophila melanogaster, the trachea.This work dissects embryonic trachea maturation. Three precise epithelial transitions occur during airway maturation. A secretion burst deposits proteins into the lumen; then luminal material is cleared and finally liquid is removed. We identified the cellular mechanisms behind these transitions. Sar1 and γCOP are
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15

Leggett, Julian James. "Airway remodelling in asthma." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485059.

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Asthma management places significant financial demands on health services. With increased understanding of the mediators involved in asthma pathophysiology more specific agents could be developed for treatment. We studied the effects of oxidant injury- on adult asthmatic cells in vitro and showed asthmatic epithelium more susceptible to oxidative stress at high concentrations of hydrogen peroxide. Cell death occurred via caspase independent apoptosis. However, at lower doses of hydrogen peroxide proliferation was observed suggesting a biphasic response. We investigated levels of Matrix Metallo
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16

IJpma, Gijs. "Airway smooth muscle dynamics." AUT University, 2010. http://hdl.handle.net/10292/941.

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The current study aims to investigate the relative contributions of each of the processes that govern airway smooth muscle mechanical behaviour. Studies have shown that breathing dynamics have a substantial effect on airway constriction in healthy and diseased subjects, yet little is known about the dynamic response of the main instigator of airway constriction, Airway Smooth Muscle (ASM). In this work several models are developed to further the understanding of ASM dynamics, particularly the roles and interactions of the three dominant processes in the muscle: contractile dynamics, length ada
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17

Reale, Riccardo. "Microfluidic airway on-chip." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/420762/.

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Organs-on-chip are a new class of in vitro devices aimed at improving the predictivity of preclinical drug testing models by integrating physiologically relevant features in cell culture devices using microfabrication techniques. In human bodies, epithelial tissues are the first line of defence against the external environment and act as barriers by expressing inter-cellular protein complexes called tight junctions (TJ). The epithelial physical barrier has selective permeability properties which can experimentally be measured by electrical means. In this thesis, the design, simulation, modelli
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18

Kottyan, Leah Claire. "Airway Acidification in Asthma." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1280778640.

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19

Crump, Gwyn N. "Caffeine and airway resistance." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000559.

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20

Boustany, Sarah. "Mechanisms of Airway Remodelling." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3577.

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Asthma is an inflammatory disease characterised by tissue remodelling. A prominent feature of this remodelling is an increase in the number and size of the blood vessels- formed from pre-existing capillaries – angiogenesis (Siddiqui et al., 2007; Wilson, 2003). This is triggered by many different endogenous angiogenic stimulators such as vascular endothelial growth factor (VEGF), and inhibited by endogenous angiogenic inhibitors such as tumstatin. Tumstatin is the non-collagenous domain (NC1) of the collagen IV α3 chain which, when cleaved, inhibits endothelial cell proliferation and induces a
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21

Boustany, Sarah. "Mechanisms of Airway Remodelling." University of Sydney, 2008. http://hdl.handle.net/2123/3577.

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Doctor of Philosophy (PhD)<br>Asthma is an inflammatory disease characterised by tissue remodelling. A prominent feature of this remodelling is an increase in the number and size of the blood vessels- formed from pre-existing capillaries – angiogenesis (Siddiqui et al., 2007; Wilson, 2003). This is triggered by many different endogenous angiogenic stimulators such as vascular endothelial growth factor (VEGF), and inhibited by endogenous angiogenic inhibitors such as tumstatin. Tumstatin is the non-collagenous domain (NC1) of the collagen IV α3 chain which, when cleaved, inhibits endothelial ce
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22

Crump, Gwyn N. M. D. "Caffeine and Airway Resistance." Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/1002.

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This study investigated the effect of caffeine on airway resistance. The subjects were drawn from volunteers (18-90 years old) in good health, with no major cardiopulmonary conditions. We found no association between the consumption of a single cup of the caffeinated beverage coffee and a decrease in airway resistance within one hour in a normal sample of subjects as measured by impulse oscillometry nor with conventional spirometry . It appears that any possible bronchodilatory effect of the caffeine from a single cup of coffee in a normal population is below the limit of detection of spiromet
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23

Pascoe, Christopher Daniel. "Mechanical and molecular contribution of airway smooth muscle to airway hyperresponsiveness in asthma." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/51862.

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This thesis focuses on the mechanical and molecular role of airway smooth muscle (ASM) in asthma with the aim to determine the contribution of ASM to both asthma and airway hyperresponsiveness (AHR). The first three chapters involve studies probing the mechanical properties of tracheal ASM strips and how these may contribute to the development of AHR. They will aim to show that ASM can contribute to AHR without fundamental changes to the tissue. Specifically, the first chapter investigated the ASMs response to force oscillations mimicking breathing maneuvers under levels of activation that ind
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24

Sammut, David. "Airway remodelling in asthma : aspects of airway wall thickness and extracellular matrix production." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/404048/.

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25

Liu, Jia Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "Nitric oxide in airway inflammation." Publisher:University of New South Wales. Clinical School - Prince of Wales Hospital, 2009. http://handle.unsw.edu.au/1959.4/43678.

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Exhaled breath condensate (EBC) is a non-invasive method of investigating airway inflammation associated with nitric oxide (NO) and the metabolites nitrite/nitrates (NOx) in diseases such as chronic obstructive pulmonary disease (COPD), but some of the variables affecting the results are unknown. It was hypothesised that 1) EBC would be influenced by lung volumes and the type of EBC collection device; 2) fractional exhaled NO (FENO) and EBC NOx in COPD patients would be altered by smoking and glucocorticosteroids (GCS); 3) cigarette smoke could contribute to the EBC NOx concentration while it
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26

Bálint, Tibor Sándor. "Dynamics of the upper airway." Thesis, University of Warwick, 2001. http://wrap.warwick.ac.uk/66409/.

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Fluid—structure interaction problems occur in everyday life, from medicine to aerospace engineering. One of the general questions from the field of bio-engineering is related to the interaction of a flexible cantilevered plate embedded in a channel flow. Further examining this problem, the motivation for the current study is the desire to elucidate the instability mechanisms of the upper airway with a view to understanding the medical conditions of snoring and obstructive sleep apnoea/hypopnea (OSAH). Snoring is caused by fluttering motions of the soft palate. OSAH involves complete or partial
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27

Inglis, Timothy J. J. "Colonisation of the ventilated airway." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259486.

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28

McIlwaine, Patricia Margaret. "Airway clearance in cystic fibrosis." Thesis, Ulster University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625501.

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This thesis overviews and highlights a body of work performed at the BC Children's Hospital, Vancouver, Canada between 1986 and 2013, and involving travel to Belgium, Denmark and the United Kingdom. It is based on five articles published by McIlwaine on research and development in the use of various airway clearance techniques for the treatment of cystic fibrosis, namely: Autogenic Drainage; Positive Expiratory Pressure; Oscillating Positive Expiratory Pressure; and High Frequency Chest Wall Oscillation. The thesis comprises of seven chapters, including the introduction. Chapter 2 presents the
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29

Marshall, Ian. "Acoustic reflectometry for airway measurement." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19987.

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30

Wood, Lorna J. "The role of bone marrow progenitor cells in allergen-induced airway hyperresponsiveness and airway inflammation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0028/NQ51023.pdf.

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31

Lee, Lewis On Hang. "Development of Simulation Platform for Oropharyngeal Airway Placement and Design Evaluation of the Bardo Airway." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/901.

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Off-label use of traditional Oropharyngeal Airway (OPA) as a bite-block, and the subsequential procedure of force exertion of the device by physician has caused many cases of patient’s teeth damage and monetary loss, as the patient’s incisors were damaged while clenching on the OPA during an adverse scenario called “Emergency Clenching”. To remedy this harmful situation, Bardo OPA was developed by Dr. Theodore Burdumy. The Bardo airway has unique design to transfer the clenching force from incisor to the molar. However, the Bardo OPA is one-sized, and cannot fit most of the patients like the c
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32

Kleine-Brüggeney, Maren. "A cross-over comparison of the laryngeal mask airway Supreme and the laryngeal mask airway I-gel in a simulated difficult airway scenario in anasthetized patients /." [S.l.] : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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33

Nilsson, Harriet. "Studies of Tight Junctions and Airway Surface Liquid in Airway Epithelium with Relevance to Cystic Fibrosis." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99411.

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Cystic fibrosis (CF) is a multi-organ autosomal recessive disease of fluid-transporting epithelia, due to a mutation in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is a cAMP-regulated Cl-channel involved in various regulatory processes. Salt and water transport depend on CFTR and the epithelial sodium channel (ENaC), operating in concert with the paracellular pathway through the tight junctions (TJ). The ionic composition of the ASL has been assumed to be altered in CF, resulting in a fatal accumulation of viscous mucus in the airways. ASL s
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34

Blumerich, Celeste Ann. "Comparison of Airway Response in Recurrent Airway Obstruction-Affected Horses Fed Steamed Versus Non-steamed Hay." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/43534.

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Recurrent Airway Obstruction (RAO)-affected horses experience bronchoconstriction and airway inflammation in response to inhalation of irritants including hay molds. Steaming hay reduces fungal content, but the effect on the antigenic potential has not been investigated. We tested the hypothesis that RAO-affected horses develop less severe clinical disease when fed steamed versus non-steamed hay and this reduction coincides with decreased hay fungal content. Six RAO-affected horses in clinical remission were divided in two groups and fed steamed or non-steamed hay for 10 days using a two-w
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35

Barker, Bethan Louise. "Exploring the interplay between airway bacteria, airway inflammation, lung structure and skeletal muscle dysfunction in COPD." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/39977.

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Airway bacteria, airway inflammation, lung structure and skeletal muscle dysfunction are all recognised as important components of chronic obstructive pulmonary disease (COPD), yet the interplay between these components is not well understood. Within this thesis I present an observational study exploring relationships between airway inflammation and molecular measures of potentially pathogenic bacteria. I have shown that airway bacterial detection is associated with increased airway inflammation in stable COPD, and that this association appears to be driven by Haemophilus influenzae. I then pr
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36

Huynh, Bao Khanh. "An in vitro hybrid method used to model realistic airway deposition and post-deposition behaviour for orally inhaled products." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/19699.

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This research focuses on the development and validation of a new in vitro test method capable of characterising realistic airway deposition of inhaled pharmaceutical aerosols, and the events following deposition at the airway epithelia. An existing physical model of a medium-sized Virginia Commonwealth University (VCU) mouth throat (MT) and tracheal bronchial (TB) upper airway was modified and validated to integrate Calu-3 monolayers cells cultured onto Snapwell® inserts for the collection of deposited drug. The model was housed in a chamber and validation was carried out using two nebulised c
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37

McConnell, William David. "Mediators of airway remodelling in asthma." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288445.

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38

Mulrennan, Siobhain A. "Diagnosis and treatment in airway inflammation." Thesis, University of Hull, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441682.

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39

Siva, Roshan. "Modulation of airway inflammation in COPD." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/4732.

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Inflammation in foregut derivatives outside the lung may contribute to amplification of airway inflammation. I have shown that a management strategy aiming to minimise eosinophilic airway inflammation as well as symptoms is associated with a significant 62% reduction in the frequency of severe exacerbations of COPD. This strategy was associated with no overall increase in corticosteroid treatment; there was evidence that increased corticosteroid therapy was targeted to patients with eosinophilic airway inflammation and benefit was largely confined to these patients. I have shown an association
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40

Du, Youhua. "Airway smooth muscle response to vibrations." AUT University, 2006. http://hdl.handle.net/10292/974.

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The main goal of this research was the in vitro investigation of the stiffness response of contracted airway smooth muscles under different external oscillations. Living animal airway smooth muscle tissues were dissected from pig tracheas and stimulated by a chemical stimulus (acetylcholine). These tissues were then systematically excited with different external vibrations. The force change was recorded to reflect the muscle stiffness change under vibration. The static and dynamic stiffness of contracted airway smooth muscles in isometric contraction were determined before, during and after vi
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41

Kharitonov, Sergei Alexandrovich. "Exhaled nitric oxide in airway diseases." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266411.

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42

Saravanan, Vadivelu. "Small Airway Obstruction in Rheumatoid Arthritis." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519460.

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43

Bhimrao, Sanjiv Kumar. "Airway structural changes in allergic rhinitis." Thesis, University of Southampton, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536296.

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44

Beckett, P. A. "Pharmacology of airway remodelling in asthma." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596514.

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45

Patterson, R. N. "Gut-lung interactions in airway disease." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419495.

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46

Cushley, M. J. "Adensoine and airway calibre in man." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233287.

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47

Herrmann, P. "Tissue engineering of upper airway replacements." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1533028/.

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Laryngotracheal diseases cause considerable morbidity and fully functional replacement after extensive surgical resection is still missing. Regenerative medicine has made considerable progress towards clinical transplantation and offers a potentially attractive solution. To date the use of biological scaffolds is considered promising for tissue engineering, providing structural and microbiological support for cell seeding and integration in the host environment. This thesis investigates the possibility of developing a decellularization protocol suitable for the production of upper airway const
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48

Schorr, Raphael Avram 1976. "Essays on airport and airway congestion." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/38246.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2006.<br>Includes bibliographical references (p. 163-166).<br>Runway and airspace congestion are the primary causes of flight delays in the US. These delays cost airlines and airline customers billions of dollars per year. This thesis consists of two essays. The first essay focuses on several of the commonly proposed market-based solutions to airport congestion. Most of the literature on these market-based solutions has assumed that these remedies are justified by welfare economics, but there
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49

Hrousis, Constantine Athanasios 1970. "Computational modeling of asthmatic airway collapse." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/32692.

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50

Grainge, Christopher. "Determinants of airway remodelling in asthma." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/384164/.

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