Log in

Relevant bibliographies by topics / Airway / Journal articles

To see the other types of publications on this topic, follow the link: Airway.

Journal articles on the topic 'Airway'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Airway.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Brown, Robert H., Wayne Mitzner, Yonca Bulut, and Elizabeth M. Wagner. "Effect of lung inflation in vivo on airways with smooth muscle tone or edema." Journal of Applied Physiology 82, no. 2 (1997): 491–99. http://dx.doi.org/10.1152/jappl.1997.82.2.491.

Full text

Abstract:

Brown, Robert H., Wayne Mitzner, Yonca Bulut, and Elizabeth M. Wagner. Effect of lung inflation in vivo on airways with smooth muscle tone or edema. J. Appl. Physiol. 82(2): 491–499, 1997.—Fibrous attachments to the airway wall and a subpleural surrounding pressure can create an external load against which airway smooth muscle must contract. A decrease in this load has been proposed as a possible cause of increased airway narrowing in asthmatic individuals. To study the interaction between the airways and the surrounding lung parenchyma, we investigated the effect of lung inflation on relaxed

APA, Harvard, Vancouver, ISO, and other styles

2

Sorkness, Ronald L., Kathryn M. Herricks, Renee J. Szakaly, Robert F. Lemanske, and Louis A. Rosenthal. "Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 1 (2007): L85—L91. http://dx.doi.org/10.1152/ajplung.00234.2006.

Full text

Abstract:

Although both asthmatics and allergic rhinitics develop an acute inflammatory response to lower airway allergen challenge, only asthmatics experience airway obstruction resulting from chronic environmental allergen exposure. Hypothesizing that asthmatic airways have an altered response to chronic allergic inflammation, we compared the effects of repeated low-level exposures to inhaled Alternaria extract in sensitized rats with preexisting chronic postbronchiolitis airway dysfunction versus sensitized controls with normal airways. Measurements of air space (bronchoalveolar lavage) inflammatory

APA, Harvard, Vancouver, ISO, and other styles

3

Noble, P. B., D. J. Turner, and H. W. Mitchell. "Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments." Journal of Applied Physiology 92, no. 3 (2002): 1119–24. http://dx.doi.org/10.1152/japplphysiol.00662.2001.

Full text

Abstract:

Structural components of the airway wall may act to load airway smooth muscle and restrict airway narrowing. In this study, the effect of load on airway narrowing was investigated in pig isolated bronchial segments. In some bronchi, pieces of cartilage were removed by careful dissection. Airway narrowing was produced by maximum electrical field stimulation. An endoscope was used to record lumen narrowing. The compliance of the bronchial segments was determined from the cross-sectional area of the lumen and the transmural pressure. Airway narrowing and the velocity of airway narrowing were incr

APA, Harvard, Vancouver, ISO, and other styles

4

Danek, Christopher J., Charles M. Lombard, Donald L. Dungworth, et al. "Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs." Journal of Applied Physiology 97, no. 5 (2004): 1946–53. http://dx.doi.org/10.1152/japplphysiol.01282.2003.

Full text

Abstract:

We delivered controlled radio frequency energy to the airways of anesthetized, ventilated dogs to examine the effect of this treatment on reducing airway narrowing caused by a known airway constrictor. The airways of 11 dogs were treated with a specially designed bronchial catheter in three of four lung regions. Treatments in each of the three treated lung regions were controlled to a different temperature (55, 65, and 75°C); the untreated lung region served as a control. We measured airway responsiveness to local methacholine chloride (MCh) challenge before and after treatment and examined po

APA, Harvard, Vancouver, ISO, and other styles

5

Naureckas, E. T., C. A. Dawson, B. S. Gerber, et al. "Airway reopening pressure in isolated rat lungs." Journal of Applied Physiology 76, no. 3 (1994): 1372–77. http://dx.doi.org/10.1152/jappl.1994.76.3.1372.

Full text

Abstract:

In a previous modeling study, we predicted that the yield pressure for airway reopening (Pyield) should depend on airway fluid surface tension (gamma) and airway radius (R), according to the relationship Pyield = 8.3 gamma/R. To test this prediction, we studied tantalum bronchograms of isolated perfused rat lungs from three rats by using microfocal X-ray imaging. Thirty-two airways with diameters ranging from 300 to 2,400 microns were recorded as the airways were collapsed and reinflated. Airway pressure was reduced transiently to -40 cmH2O to produce airway closure. Airway pressure was then s

APA, Harvard, Vancouver, ISO, and other styles

6

Brown, Robert H., and Wayne Mitzner. "Airway closure with high PEEP in vivo." Journal of Applied Physiology 89, no. 3 (2000): 956–60. http://dx.doi.org/10.1152/jappl.2000.89.3.956.

Full text

Abstract:

When airway smooth muscle is contracted in vitro, the airway lumen continues to narrow with increasing concentrations of agonist until complete airway closure occurs. Although there remains some controversy regarding whether airways can close in vivo, recent work has clearly demonstrated that, if the airway is sufficiently stimulated with contractile agonists, complete closure of even large cartilaginous conducting airways can readily occur with the lung at functional residual capacity (Brown RH and Mitzner W. J Appl Physiol 85: 2012–2017, 1998). This result suggests that the tethering of airw

APA, Harvard, Vancouver, ISO, and other styles

7

Farrow, Catherine E., Cheryl M. Salome, Benjamin E. Harris, et al. "Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthma." Journal of Applied Physiology 113, no. 6 (2012): 958–66. http://dx.doi.org/10.1152/japplphysiol.01618.2011.

Full text

Abstract:

The regional pattern and extent of airway closure measured by three-dimensional ventilation imaging may relate to airway hyperresponsiveness (AHR) and peripheral airways disease in asthmatic subjects. We hypothesized that asthmatic airways are predisposed to closure during bronchoconstriction in the presence of ventilation heterogeneity and AHR. Fourteen asthmatic subjects (6 women) underwent combined ventilation single photon emission computed tomography/computed tomography scans before and after methacholine challenge. Regional airway closure was determined by complete loss of ventilation fo

APA, Harvard, Vancouver, ISO, and other styles

8

Zimmermann, Nives, Marc Rothenberg, and Leah Kottyan. "IL-13 is required and sufficient for airway acidification in allergic airway inflammation (141.16)." Journal of Immunology 184, no. 1_Supplement (2010): 141.16. http://dx.doi.org/10.4049/jimmunol.184.supp.141.16.

Full text

Abstract:

Abstract Clinical studies have shown acidification of airways in asthma. Importantly, studies have suggested that acidification contributes to the pathophysiological process. However, the mechanism of acidification is unclear. We developed a novel method for measuring the acidity of mouse airways and demonstrated that mouse airways are acidified during models of allergic airway inflammation. Our studies determined that airway acidification does not develop in IL-13-deficient mice and that IL-13 delivery alone is sufficient to induce airway acidification. There are multiple ways IL-13 could lea

APA, Harvard, Vancouver, ISO, and other styles

9

Bai, Yan, and Michael J. Sanderson. "The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 296, no. 6 (2009): L947—L958. http://dx.doi.org/10.1152/ajplung.90288.2008.

Full text

Abstract:

To determine the relative contributions of Ca2+ signaling and Ca2+ sensitivity to the contractility of airway smooth muscle cells (SMCs), we compared the contractile responses of mouse and rat airways with the lung slice technique. Airway contraction was measured by monitoring changes in airway lumen area with phase-contrast microscopy, whereas changes in intracellular calcium concentration ([Ca2+]i) of the SMCs were recorded with laser scanning microscopy. In mice and rats, methacholine (MCh) or serotonin induced concentration-dependent airway contraction and Ca2+ oscillations in the SMCs. Ho

APA, Harvard, Vancouver, ISO, and other styles

10

Ma, Baoshun, and Jason H. T. Bates. "Mechanical interactions between adjacent airways in the lung." Journal of Applied Physiology 116, no. 6 (2014): 628–34. http://dx.doi.org/10.1152/japplphysiol.01180.2013.

Full text

Abstract:

The forces of mechanical interdependence between the airways and the parenchyma in the lung are powerful modulators of airways responsiveness. Little is known, however, about the extent to which adjacent airways affect each other's ability to narrow due to distortional forces generated within the intervening parenchyma. We developed a two-dimensional computational model of two airways embedded in parenchyma. The parenchyma itself was modeled in three ways: 1) as a network of hexagonally arranged springs, 2) as a network of triangularly arranged springs, and 3) as an elastic continuum. In all c

APA, Harvard, Vancouver, ISO, and other styles

11

Paré, Peter D., and Wayne Mitzner. "Airway‐Parenchymal Interdependence." Comprehensive Physiology 2, no. 3 (2012): 1921–35. https://doi.org/10.1002/j.2040-4603.2012.tb00449.x.

Full text

Abstract:

AbstractIn this article, we discuss the interaction of the lung parenchyma and the airways as well as the physiological and pathophysiological significance of this interaction. These two components of the respiratory organ can be thought of as two independent elastic structures but in fact the mechanical properties of one influence the behavior of the other. Traditionally, the interaction has focused on the effects of the lung on the airways but there is good evidence that the opposite is also true, that is, that the mechanical properties of the airways influence the elastic properties of the

APA, Harvard, Vancouver, ISO, and other styles

12

Okazawa, M., S. Vedal, L. Verburgt, R. K. Lambert, and P. D. Pare. "Determinants of airway smooth muscle shortening in excised canine lobes." Journal of Applied Physiology 78, no. 2 (1995): 608–14. http://dx.doi.org/10.1152/jappl.1995.78.2.608.

Full text

Abstract:

There is marked heterogeneity of airway narrowing in intraparenchymal airways in response to bronchoconstricting stimuli. We hypothesized that this heterogeneity results from variations in the structure of the airway wall. Freshly excised dog lung lobes were inflated to transpulmonary pressures (PL) of between 5 and 15 cmH2O, and an aerosol containing a high concentration of carbachol was administered. The lobes were fixed and processed for light-microscopic examination and morphometric analysis of membranous airway dimensions. The relationships of smooth muscle shortening to PL and airway dim

APA, Harvard, Vancouver, ISO, and other styles

13

Henry, Peter J., Tracy S. Mann, Angela C. D'Aprile, Glenn J. Self, and Roy G. Goldie. "An endothelin receptor antagonist, SB-217242, inhibits airway hyperresponsiveness in allergic mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 283, no. 5 (2002): L1072—L1078. http://dx.doi.org/10.1152/ajplung.00076.2002.

Full text

Abstract:

Within the airways, endothelin-1 (ET-1) can exert a range of prominent effects, including airway smooth muscle contraction, bronchial obstruction, airway wall edema, and airway remodeling. ET-1 also possesses proinflammatory properties and contributes to the late-phase response in allergic airways. However, there is no direct evidence for the contribution of endogenous ET-1 to airway hyperresponsiveness in allergic airways. Allergic inflammation induced in mice by sensitization and challenge with the house dust mite allergen Der P1 was associated with elevated levels of ET-1 within the lung, i

APA, Harvard, Vancouver, ISO, and other styles

14

Brown, Robert H., Wayne Mitzner, and Elizabeth M. Wagner. "Interaction between airway edema and lung inflation on responsiveness of individual airways in vivo." Journal of Applied Physiology 83, no. 2 (1997): 366–70. http://dx.doi.org/10.1152/jappl.1997.83.2.366.

Full text

Abstract:

Brown, Robert H., Wayne Mitzner, and Elizabeth M. Wagner.Interaction between airway edema and lung inflation on responsiveness of individual airways in vivo. J. Appl. Physiol. 83(2): 366–370, 1997.—Inflammatory changes and airway wall thickening are suggested to cause increased airway responsiveness in patients with asthma. In five sheep, the dose-response relationships of individual airways were measured at different lung volumes to methacholine (MCh) before and after wall thickening caused by the inflammatory mediator bradykinin via the bronchial artery. At 4 cmH2O transpulmonary pressure (P

APA, Harvard, Vancouver, ISO, and other styles

15

Brown, R. H., and W. Mitzner. "Effect of lung inflation and airway muscle tone on airway diameter in vivo." Journal of Applied Physiology 80, no. 5 (1996): 1581–88. http://dx.doi.org/10.1152/jappl.1996.80.5.1581.

Full text

Abstract:

How normal airway dimensions change with lung volume is of great importance in determining flow limitation during the normal forced vital capacity maneuver as well as in the manifestation of obstructive lung disease. The literature presents a confusing picture, with some results suggesting that airway diameter increases linearly with the cube root of lung volume and others showing a highly nonlinear relation. The effect of smooth muscle contraction on lung-airway interdependence is even less well understood. Recent morphological work explicitly assumes that airway basement membrane is nondiste

APA, Harvard, Vancouver, ISO, and other styles

16

Shahi, Niti, Ryan Phillips, Maxene Meier, et al. "Outcomes of Airway Management in Micrognathia and Retrognathia Patients Born at Fetal versus Nonfetal Centers." Fetal Diagnosis and Therapy 47, no. 12 (2020): 933–38. http://dx.doi.org/10.1159/000510856.

Full text

Abstract:

<b><i>Objectives:</i></b> There is a paucity of evidence to guide the perinatal management of difficult airways in fetuses with micrognathia. We aimed to (1) develop a postnatal grading system based on the extent of airway intervention required at birth to assess the severity of micrognathic airways and (2) compare trends in airway management and outcomes by location of birth [nonfetal center (NFC), defined as a hospital with or without an NICU and no fetal team, versus fetal center (FC), defined as a hospital with an NICU and fetal team]. <b><i>Methods:<

APA, Harvard, Vancouver, ISO, and other styles

17

Rosenberg, M. B., J. C. Phero, and D. E. Becker. "Essentials of Airway Management, Oxygenation, and Ventilation: Part 2: Advanced Airway Devices: Supraglottic Airways." Anesthesia Progress 61, no. 3 (2014): 113–18. http://dx.doi.org/10.2344/0003-3006-61.3.113.

Full text

Abstract:

Abstract Offices and outpatient dental facilities must be properly equipped with devices for airway management, oxygenation, and ventilation. Part 1 in this series on emergency airway management focused on basic and fundamental considerations for supplying supplemental oxygen to the spontaneously breathing patient and utilizing a bag-valve-mask system including nasopharyngeal and oropharyngeal airways to deliver oxygen under positive pressure to the apneic patient. This article will review the evolution and use of advanced airway devices, specifically supraglottic airways, with the emphasis on

APA, Harvard, Vancouver, ISO, and other styles

18

Shifren, Adrian, Chad Witt, Chandrika Christie, and Mario Castro. "Mechanisms of Remodeling in Asthmatic Airways." Journal of Allergy 2012 (January 19, 2012): 1–12. http://dx.doi.org/10.1155/2012/316049.

Full text

Abstract:

Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline. The structural changes in the airways of these patients are referred to as airway remodeling. All elements of the airway wall are involved, and remodeled airway wall thickness is substantially increased compared to normal control airways. Airway remodeling is thought to contribute to the subphenotypes

APA, Harvard, Vancouver, ISO, and other styles

19

Royce, Simon G., Anna M. Tominaga, Matthew Shen, et al. "Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease." Clinical Science 130, no. 23 (2016): 2151–65. http://dx.doi.org/10.1042/cs20160328.

Full text

Abstract:

We have identified combination cell-based therapies that effectively treat the airway inflammation and airway remodelling (structural changes) that contribute to airway obstruction and related airway hyperresponsiveness in murine chronic allergic airways.

APA, Harvard, Vancouver, ISO, and other styles

20

Kott, Kayleen S., Kent E. Pinkerton, John M. Bric, Charles G. Plopper, Krishna P. Avadhanam, and Jesse P. Joad. "Methacholine responsiveness of proximal and distal airways of monkeys and rats using videomicrometry." Journal of Applied Physiology 92, no. 3 (2002): 989–96. http://dx.doi.org/10.1152/japplphysiol.00415.2001.

Full text

Abstract:

Rat and monkey are species that are used in models of human airway hyperresponsiveness. However, the wall structures of rat and monkey airways are different from each other, with that of the monkey more closely resembling that of humans. We hypothesized that differences in wall structure would explain differences in airway responsiveness. Using videomicrometry, we measured airway luminal area in lung slices to compare proximal and distal airway responsiveness to methacholine in the rat and monkey. The airway type was then histologically identified. Proximal airways of the young rat and monkey

APA, Harvard, Vancouver, ISO, and other styles

21

Cailleau, Loic, Thomas Geeraerts, Vincent Minville, et al. "Is there a benefit for anesthesiologists of adding difficult airway scenarios for learning fiberoptic intubation skills using virtual reality training? A randomized controlled study." PLOS ONE 18, no. 1 (2023): e0281016. http://dx.doi.org/10.1371/journal.pone.0281016.

Full text

Abstract:

Fiberoptic intubation for a difficult airway requires significant experience. Traditionally only normal airways were available for high fidelity bronchoscopy simulators. It is not clear if training on difficult airways offers an advantage over training on normal airways. This study investigates the added value of difficult airway scenarios during virtual reality fiberoptic intubation training. A prospective multicentric randomized study was conducted 2019 to 2020, among 86 inexperienced anesthesia residents, fellows and staff. Two groups were compared: Group N (control, n = 43) first trained o

APA, Harvard, Vancouver, ISO, and other styles

22

Kirchner, K. K., and J. T. McBride. "Changes in airway length after unilateral pneumonectomy in weanling ferrets." Journal of Applied Physiology 68, no. 1 (1990): 187–92. http://dx.doi.org/10.1152/jappl.1990.68.1.187.

Full text

Abstract:

We have previously shown that airway cross-sectional area increases 15-20% after pneumonectomy in weanling ferrets by measuring bronchial casts. We have now reanalyzed these same casts to quantitate changes in airway length after pneumonectomy. In each cast the distance from each of 120 airways to the terminal bronchiole along its axial pathway was measured. The relationship between the logarithm of this distance and that of the fraction of the lobe subtended by an airway could be described by a quadratic equation with a correlation coefficient greater than 0.85. Subsegmental and more distal a

APA, Harvard, Vancouver, ISO, and other styles

23

Gunst, S. J., D. O. Warner, T. A. Wilson, and R. E. Hyatt. "Parenchymal interdependence and airway response to methacholine in excised dog lobes." Journal of Applied Physiology 65, no. 6 (1988): 2490–97. http://dx.doi.org/10.1152/jappl.1988.65.6.2490.

Full text

Abstract:

The objective of this investigation was to determine the minimum transpulmonary pressure (PL) at which the forces of interdependence between the airways and the lung parenchyma can prevent airway closure in response to maximal stimulation of the airways in excised canine lobes. We first present an analysis of the relationship between PL and the transmural pressure (Ptm) that airway smooth muscle must generate to close the airways. This analysis predicts that airway closure can occur at PL less than or equal to 10 cmH2O with maximal airway stimulation. We tested this prediction in eight excised

APA, Harvard, Vancouver, ISO, and other styles

24

Gallos, George, Elizabeth Townsend, Peter Yim, et al. "Airway epithelium is a predominant source of endogenous airway GABA and contributes to relaxation of airway smooth muscle tone." American Journal of Physiology-Lung Cellular and Molecular Physiology 304, no. 3 (2013): L191—L197. http://dx.doi.org/10.1152/ajplung.00274.2012.

Full text

Abstract:

Chronic obstructive pulmonary disease and asthma are characterized by hyperreactive airway responses that predispose patients to episodes of acute airway constriction. Recent studies suggest a complex paradigm of GABAergic signaling in airways that involves GABA-mediated relaxation of airway smooth muscle. However, the cellular source of airway GABA and mechanisms regulating its release remain unknown. We questioned whether epithelium is a major source of GABA in the airway and whether the absence of epithelium-derived GABA contributes to greater airway smooth muscle force. Messenger RNA encod

APA, Harvard, Vancouver, ISO, and other styles

25

Fasano, Mary Beth. "Combined airways: impact of upper airway on lower airway." Current Opinion in Otolaryngology & Head and Neck Surgery 18, no. 1 (2010): 15–20. http://dx.doi.org/10.1097/moo.0b013e328334aa0e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Sheel, A. William, Jordan A. Guenette, Ren Yuan, et al. "Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers." Journal of Applied Physiology 107, no. 5 (2009): 1622–28. http://dx.doi.org/10.1152/japplphysiol.00562.2009.

Full text

Abstract:

We sought to determine the relationship between lung size and airway size in men and women of varying stature. We also asked if men and women matched for lung size would still have differences in airway size and if so where along the pulmonary airway tree would these differences exist. We used computed tomography to measure airway luminal areas of the large and central airways. We determined airway luminal areas in men ( n = 25) and women ( n = 25) who were matched for age, body mass index, smoking history, and pulmonary function and in a separate set of men ( n = 10) and women ( n = 11) who w

APA, Harvard, Vancouver, ISO, and other styles

27

Tanabe, Naoya, Kaoruko Shimizu, Kunihiko Terada, et al. "Central airway and peripheral lung structures in airway disease-dominant COPD." ERJ Open Research 7, no. 1 (2021): 00672–2020. http://dx.doi.org/10.1183/23120541.00672-2020.

Full text

Abstract:

The concept that the small airway is a primary pathological site for all COPD phenotypes has been challenged by recent findings that the disease starts from the central airways in COPD subgroups and that a smaller central airway tree increases COPD risk. This study aimed to examine whether the computed tomography (CT)-based airway disease-dominant (AD) subtype, defined using the central airway dimension, was less associated with small airway dysfunction (SAD) on CT, compared to the emphysema-dominant (ED) subtype.COPD patients were categorised into mild, AD, ED and mixed groups based on wall a

APA, Harvard, Vancouver, ISO, and other styles

28

Noble, Peter B., Robyn L. Jones, Alvenia Cairncross, et al. "Airway narrowing and bronchodilation to deep inspiration in bronchial segments from subjects with and without reported asthma." Journal of Applied Physiology 114, no. 10 (2013): 1460–71. http://dx.doi.org/10.1152/japplphysiol.01489.2012.

Full text

Abstract:

The present study presents preliminary findings on how structural/functional abnormalities of the airway wall relate to excessive airway narrowing and reduced bronchodilatory response to deep inspiration (DI) in subjects with a history of asthma. Bronchial segments were acquired from subjects undergoing surgery, mostly to remove pulmonary neoplasms. Subjects reported prior doctor-diagnosed asthma ( n = 5) or had no history of asthma ( n = 8). In vitro airway narrowing in response to acetylcholine was assessed to determine maximal bronchoconstriction and sensitivity, under static conditions and

APA, Harvard, Vancouver, ISO, and other styles

29

Mahjour, Seyed B., Kazunori Gomi, Busub Lee, Olivier Elemento, Scott Randell, and Renat Shaykhiev. "2566 Personalized models of distal airway epithelial-stromal unit in COPD." Journal of Clinical and Translational Science 2, S1 (2018): 23. http://dx.doi.org/10.1017/cts.2018.106.

Full text

Abstract:

OBJECTIVES/SPECIFIC AIMS: The objective of this study is to develop patient-derived “personalized” organotypic models of human distal airways, in which basal stem cells (BCs) isolated from the pre-/terminal conducting airway region are co-cultured with autologous stromal cells from the same region to reproduce patient-specific distal airway epithelial-stromal units and their remodeling in COPD. METHODS/STUDY POPULATION: We established a protocol to isolate and propagate epithelial BCs, fibroblasts, and endothelial cells from the distal airways of normal and COPD lung donors. Heterogeneous cell

APA, Harvard, Vancouver, ISO, and other styles

30

Li, Xiaopeng, Xiao Xiao Tang, Luis G. Vargas Buonfiglio, et al. "Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense." American Journal of Physiology-Lung Cellular and Molecular Physiology 310, no. 7 (2016): L670—L679. http://dx.doi.org/10.1152/ajplung.00422.2015.

Full text

Abstract:

While pathological and clinical data suggest that small airways are involved in early cystic fibrosis (CF) lung disease development, little is known about how the lack of cystic fibrosis transmembrane conductance regulator (CFTR) function contributes to disease pathogenesis in these small airways. Large and small airway epithelia are exposed to different airflow velocities, temperatures, humidity, and CO2 concentrations. The cellular composition of these two regions is different, and small airways lack submucosal glands. To better understand the ion transport properties and impacts of lack of

APA, Harvard, Vancouver, ISO, and other styles

31

Barnes, P. J. "Muscarinic receptors in airways: recent developments." Journal of Applied Physiology 68, no. 5 (1990): 1777–85. http://dx.doi.org/10.1152/jappl.1990.68.5.1777.

Full text

Abstract:

Recently there have been important advances in our understanding of muscarinic receptors in airways that have important implications for understanding airway control and for future therapy of airway diseases. The transduction mechanisms involved in muscarinic receptor activation are now better understood. Receptor-linked phosphoinositide hydrolysis leads to release of calcium ions from intracellular stores, resulting in contraction of airway smooth muscle. At least five subtypes of muscarinic receptor have now been cloned, although only three subtypes can be distinguished pharmacologically. M1

APA, Harvard, Vancouver, ISO, and other styles

32

Sykes, Peter, Lucy Elliott, and Matthew Rowe. "Maintaining the airway." InnovAiT: Education and inspiration for general practice 12, no. 10 (2019): 561–68. http://dx.doi.org/10.1177/1755738019863825.

Full text

Abstract:

Airway-related problems can present in primary care. As first-contact care providers, GPs may encounter a range of airway emergencies that require urgent intervention. Patients may have residual symptoms from procedures such as endotracheal intubation or require specialised airways such as a tracheostomy in the community. This article concentrates on two issues focusing on the adult patient population. First, we discuss emergency airway maintenance in accordance with basic life support. Second, we explore the care of patients living with specialised airways in the community from a physical, ps

APA, Harvard, Vancouver, ISO, and other styles

33

Ramchandani, R., X. Shen, C. L. Elmsley, W. T. Ambrosius, S. J. Gunst, and R. S. Tepper. "Differences in airway structure in immature and mature rabbits." Journal of Applied Physiology 89, no. 4 (2000): 1310–16. http://dx.doi.org/10.1152/jappl.2000.89.4.1310.

Full text

Abstract:

Our laboratory has previously demonstrated that maximal bronchoconstriction produces a greater degree of airway narrowing in immature than in mature rabbit lungs (33). To determine whether these maturational differences could be related to airway structure, we compared the fraction of the airway wall occupied by airway smooth muscle (ASM) and cartilage, the proportion of wall area internal to ASM, and the number of alveolar attachments to the airways, from mature and immature (6-mo- and 4-wk-old, respectively) rabbit lungs that were formalin fixed at total lung capacity. The results demonstrat

APA, Harvard, Vancouver, ISO, and other styles

34

Phung, Thien-Khoi N., Scott E. Sinclair, Patrudu Makena, Robert C. Molthen, and Christopher M. Waters. "Dynamic airway constriction in rats: heterogeneity and response to deep inspiration." American Journal of Physiology-Lung Cellular and Molecular Physiology 317, no. 1 (2019): L39—L48. http://dx.doi.org/10.1152/ajplung.00050.2019.

Full text

Abstract:

Airway narrowing due to hyperresponsiveness severely limits gas exchange in patients with asthma. Imaging studies in humans and animals have shown that bronchoconstriction causes patchy patterns of ventilation defects throughout the lungs, and several computational models have predicted that these regions are due to constriction of smaller airways. However, these imaging approaches are often limited in their ability to capture dynamic changes in small airways, and the patterns of constriction are heterogeneous. To directly investigate regional variations in airway narrowing and the response to

APA, Harvard, Vancouver, ISO, and other styles

35

Noble, Peter B., Adrian R. West, Robert A. McLaughlin, et al. "Airway narrowing assessed by anatomical optical coherence tomography in vitro: dynamic airway wall morphology and function." Journal of Applied Physiology 108, no. 2 (2010): 401–11. http://dx.doi.org/10.1152/japplphysiol.00511.2009.

Full text

Abstract:

Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural, and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber, these have typically been studied separately: the former primarily using histological approaches, the latter with a range of imaging modalities. We describe a new optical technique, anatom

APA, Harvard, Vancouver, ISO, and other styles

36

Riley, R. H., T. Strang, and S. Rao. "Survey of Airway Skills of Surgeons in Western Australia." Anaesthesia and Intensive Care 37, no. 4 (2009): 630–33. http://dx.doi.org/10.1177/0310057x0903700406.

Full text

Abstract:

Our objective was to survey all consultant surgeons, including obstetricians/gynaecologists, in the State of Western Australia to assess their experience with, and readiness to assist anaesthetists with a difficult or failed airway. Survey questionnaires were mailed to all surgeons registered in Western Australia (n=445). A total of 238 responses (53%) were received, mostly from general surgeons, obstetrician/gynaecologists and orthopaedic surgeons. Forty percent had provided non-surgical assistance with a difficult airway and 60% had assisted with a surgical airway. All ear, nose and throat s

APA, Harvard, Vancouver, ISO, and other styles

37

Lambert, R. K., R. Ramchandani, X. Shen, S. J. Gunst, and R. S. Tepper. "Computational model of airway narrowing: mature vs. immature rabbit." Journal of Applied Physiology 93, no. 2 (2002): 611–19. http://dx.doi.org/10.1152/japplphysiol.00063.2002.

Full text

Abstract:

Immature rabbits have greater maximal airway narrowing and greater maximal fold increases in airway resistance during bronchoconstriction than mature animals. We have previously demonstrated that excised immature rabbit lungs have more distensible airways, a lower shear modulus, and structural differences in the relative composition and thickness of anatomically similar airways. In the present study, we incorporated anatomic and physiological data for mature and immature rabbits into a computational model of airway narrowing. We then investigated the relative importance of maturational differe

APA, Harvard, Vancouver, ISO, and other styles

38

Titze, Ingo R., Anil Palaparthi, Karin Cox, Amanda Stark, Lynn Maxfield, and Brian Manternach. "Vocalization with semi-occluded airways is favorable for optimizing sound production." PLOS Computational Biology 17, no. 3 (2021): e1008744. http://dx.doi.org/10.1371/journal.pcbi.1008744.

Full text

Abstract:

Vocalization in mammals, birds, reptiles, and amphibians occurs with airways that have wide openings to free-space for efficient sound radiation, but sound is also produced with occluded or semi-occluded airways that have small openings to free-space. It is hypothesized that pressures produced inside the airway with semi-occluded vocalizations have an overall widening effect on the airway. This overall widening then provides more opportunity to produce wide-narrow contrasts along the airway for variation in sound quality and loudness. For human vocalization described here, special emphasis is

APA, Harvard, Vancouver, ISO, and other styles

39

Chapman, David G., Norbert Berend, Gregory G. King, and Cheryl M. Salome. "Effect of deep inspiration avoidance on ventilation heterogeneity and airway responsiveness in healthy adults." Journal of Applied Physiology 110, no. 5 (2011): 1400–1405. http://dx.doi.org/10.1152/japplphysiol.00855.2010.

Full text

Abstract:

The mechanisms by which deep inspiration (DI) avoidance increases airway responsiveness in healthy subjects are not known. DI avoidance does not alter respiratory mechanics directly; however, computational modeling has predicted that DI avoidance would increase baseline ventilation heterogeneity. The aim was to determine if DI avoidance increased baseline ventilation heterogeneity and whether this correlated with the increase in airway responsiveness. Twelve healthy subjects had ventilation heterogeneity measured by multiple-breath nitrogen washout (MBNW) before and after 20 min of DI avoidanc

APA, Harvard, Vancouver, ISO, and other styles

40

Ramchandani, R., X. Shen, S. J. Gunst, and R. S. Tepper. "Comparison of elastic properties and contractile responses of isolated airway segments from mature and immature rabbits." Journal of Applied Physiology 95, no. 1 (2003): 265–71. http://dx.doi.org/10.1152/japplphysiol.00362.2002.

Full text

Abstract:

Immature rabbits have greater maximal airway narrowing with bronchoconstriction in vivo compared with mature animals. As isolated immature lungs have a lower shear modulus, it is unclear whether the greater airway narrowing in the immature lung is secondary to less tethering between the airways and the lung parenchyma or to differences in the mechanical properties of the mature and immature airways. In the present study, we compared the mechanical properties of fluid-filled, isolated, intraparenchymal airway segments of the same generation from mature and immature rabbits. Stimulation with ACh

APA, Harvard, Vancouver, ISO, and other styles

41

Kaczka, David W., Robert H. Brown, and Wayne Mitzner. "Assessment of heterogeneous airway constriction in dogs: a structure-function analysis." Journal of Applied Physiology 106, no. 2 (2009): 520–30. http://dx.doi.org/10.1152/japplphysiol.90576.2008.

Full text

Abstract:

Obstructive lung diseases are often characterized by heterogeneous patterns of bronchoconstriction, although specific relationships between structural heterogeneity and lung function have yet to be established. We measured respiratory input impedance (Zrs) in eight anesthetized dogs using broadband forced oscillations at baseline and during intravenous methacholine (MCh) infusion. We also obtained high-resolution computed tomographic (HRCT) scans in 4 dogs and identified 20–30 individual airway segments in each animal. The Zrs spectra and HRCT images were obtained before and 5 min following a

APA, Harvard, Vancouver, ISO, and other styles

42

Olson, L. E. "Small airway pressure-diameter relationships during nonhomogeneous lung lobe inflation." Journal of Applied Physiology 62, no. 6 (1987): 2377–82. http://dx.doi.org/10.1152/jappl.1987.62.6.2377.

Full text

Abstract:

The pressure-diameter behavior of airways within a collaterally ventilating segment of lung was evaluated radiographically in 12 excised dog lung lobes. The results were compared with the pressure-diameter behavior of airways in a lung region adjacent to the collaterally ventilating segment. Airways in each lung region were dusted with powdered tantalum, and airway diameters were measured during homogeneous and nonhomogeneous lobe inflation. Intrasegmental and extrasegmental airways behaved similarly during homogeneous lobe inflation; airway diameter increased as alveolar pressure increased. T

APA, Harvard, Vancouver, ISO, and other styles

43

Stewart, Peter S., and Oliver E. Jensen. "Patterns of recruitment and injury in a heterogeneous airway network model." Journal of The Royal Society Interface 12, no. 111 (2015): 20150523. http://dx.doi.org/10.1098/rsif.2015.0523.

Full text

Abstract:

In respiratory distress, lung airways become flooded with liquid and may collapse due to surface-tension forces acting on air–liquid interfaces, inhibiting gas exchange. This paper proposes a mathematical multiscale model for the mechanical ventilation of a network of occluded airways, where air is forced into the network at a fixed tidal volume, allowing investigation of optimal recruitment strategies. The temporal response is derived from mechanistic models of individual airway reopening, incorporating feedback on the airway pressure due to recruitment. The model accounts for stochastic vari

APA, Harvard, Vancouver, ISO, and other styles

44

Dubsky, S., G. R. Zosky, K. Perks, et al. "Assessment of airway response distribution and paradoxical airway dilation in mice during methacholine challenge." Journal of Applied Physiology 122, no. 3 (2017): 503–10. http://dx.doi.org/10.1152/japplphysiol.00476.2016.

Full text

Abstract:

Detailed information on the distribution of airway diameters during bronchoconstriction in situ is required to understand the regional response of the lungs. Imaging studies using computed tomography (CT) have previously measured airway diameters and changes in response to bronchoconstricting agents, but the manual measurements used have severely limited the number of airways measured per subject. Hence, the detailed distribution and heterogeneity of airway responses are unknown. We have developed and applied dynamic imaging and advanced image-processing methods to quantify and compare hundred

APA, Harvard, Vancouver, ISO, and other styles

45

Klučka, Jozef, Petr Štourač, Roman Štoudek, Michaela Ťoukálková, Hana Harazim, and Martina Kosinová. "Controversies in Pediatric Perioperative Airways." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/368761.

Full text

Abstract:

Pediatric airway management is a challenge in routine anesthesia practice. Any airway-related complication due to improper procedure can have catastrophic consequences in pediatric patients. The authors reviewed the current relevant literature using the following data bases: Google Scholar, PubMed, Medline (OVID SP), and Dynamed, and the following keywords: Airway/s, Children, Pediatric, Difficult Airways, and Controversies. From a summary of the data, we identified several controversies: difficult airway prediction, difficult airway management, cuffed versus uncuffed endotracheal tubes for se

APA, Harvard, Vancouver, ISO, and other styles

46

Reihill, James A., Lisa E. J. Douglas, and S. Lorraine Martin. "Modulation of Ion Transport to Restore Airway Hydration in Cystic Fibrosis." Genes 12, no. 3 (2021): 453. http://dx.doi.org/10.3390/genes12030453.

Full text

Abstract:

Cystic fibrosis (CF) is a life-limiting genetic disorder caused by loss-of-function mutations in the gene which codes for the CF transmembrane conductance regulator (CFTR) Cl− channel. Loss of Cl− secretion across the apical membrane of airway lining epithelial cells results in dehydration of the airway surface liquid (ASL) layer which impairs mucociliary clearance (MCC), and as a consequence promotes bacterial infection and inflammation of the airways. Interventions that restore airway hydration are known to improve MCC. Here we review the ion channels present at the luminal surface of airway

APA, Harvard, Vancouver, ISO, and other styles

47

Harvey, Brian C., Harikrishnan Parameswaran, and Kenneth R. Lutchen. "Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?" Journal of Applied Physiology 119, no. 1 (2015): 47–54. http://dx.doi.org/10.1152/japplphysiol.01100.2014.

Full text

Abstract:

Periodic length fluctuations of airway smooth muscle during breathing are thought to modulate airway responsiveness in vivo. Recent animal and human intact airway studies have shown that pressure fluctuations simulating breathing can only marginally reverse airway narrowing and are ineffective at protecting against future narrowing. However, these previous studies were performed on relatively large (>5 mm diameter) airways, which are inherently stiffer than smaller airways for which a preponderance of airway constriction in asthma likely occurs. The goal of this study was to determine the e

APA, Harvard, Vancouver, ISO, and other styles

48

McKay, Karen O., Barry R. Wiggs, Peter D. Paré, and Roger D. Kamm. "Zero-stress state of intra- and extraparenchymal airways from human, pig, rabbit, and sheep lung." Journal of Applied Physiology 92, no. 3 (2002): 1261–66. http://dx.doi.org/10.1152/japplphysiol.00131.2001.

Full text

Abstract:

Alterations in airway wall anatomic properties and the consequential effects on airway narrowing have been assessed by use of computational models. In these models, it is generally assumed that at zero transmural pressure the airway wall exists in a zero-stress state. Many studies have shown that this is often not the case, as evidenced by a nonzero opening angle. In this study, we measured the opening angle of airway rings at zero transmural pressure to test this assumption. The airway tree was dissected from human, pig, sheep, and rabbit lungs. Airways were excised from the tree, and the ope

APA, Harvard, Vancouver, ISO, and other styles

49

Zhang, Yaping, Lars Edvinsson, and Cang-Bao Xu. "Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity." Scientific World JOURNAL 10 (2010): 2157–66. http://dx.doi.org/10.1100/tsw.2010.204.

Full text

Abstract:

Cigarette smoke exposure is well known to cause cardiovascular and airway diseases, both of which are leading causes of death and disability in the world. However, the molecular mechanisms that link cigarette smoke to cardiovascular and airway diseases are not fully understood. Vascular and airway hyper-reactivity plays an important role in the pathogenesis of cardiovascular and airway diseases. Recent studies have demonstrated that endothelin receptor up-regulation mediates vascular and airway hyper-reactivity in response to endothelin-1 (ET-1, endothelin receptor agonist) in cardiovascular a

APA, Harvard, Vancouver, ISO, and other styles

50

Waindeskar, Vaishali, Sri Rama Ananta Nagabhushanam Padala, Shikha Jain, Molli Kiran, Pranita Mandal, and Abhijit P. Pakhare. "Prediction of the difficult airway by pre-operative ultrasound-based measurement of airway parameters: A prospective observational study." Indian Journal of Anaesthesia 67, no. 9 (2023): 785–90. http://dx.doi.org/10.4103/ija.ija_464_23.

Full text

Abstract:

ABSTRACT Background and Aims: Ultrasonography has emerged as a new airway assessment tool. However, its role in predicting difficult airways needs to be explored. This study aimed to evaluate the accuracy of pre-operative ultrasound assessment of the neck in predicting difficult airways in patients undergoing elective surgery under general anaesthesia. Methods: One hundred and fourteen adult patients undergoing elective surgeries under general anaesthesia were enrolled in this study. In the pre-operative room, upper airway ultrasound measurements of the neck were obtained, namely, distance fro

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!