Relevant bibliographies by topics / Ajmaline

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Ajmaline'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Ajmaline"

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Polz, Leo, Helmut Schübel та Joachim Stoekigt. "Characterization of 2β(R)-17-O-AcetylajmaIan: Acetylesterase — a Specific Enzyme Involved in the Biosynthesis of the Rauwolfia Alkaloid Ajmaline". Zeitschrift für Naturforschung C 42, № 4 (1987): 333–42. http://dx.doi.org/10.1515/znc-1987-0403.

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A novel enzyme was isolated, partially purified (217-fold) and characterized from cell suspen­sion cultures of Rauwolfia serpentina Benth. The enzyme catalyzes one of the late biochemical reactions in the biosynthesis of ajmaline by hydrolysis of 17-O-acetylated alkaloids of the ajmalan group forming the appropriate deacetylated compounds. This esterase exhibits an unusually high substrate selectivity and exclusively accepts acetylated ajmaline derivatives with the naturally occurring 2β(R)-configuration. The properties of the enzyme were determined showing an optimum pH at 7.5, an isoelectric
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&NA;. "Ajmaline." Reactions Weekly &NA;, no. 1370 (2011): 6. http://dx.doi.org/10.2165/00128415-201113700-00015.

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&NA;. "Ajmaline." Reactions Weekly &NA;, no. 1335 (2011): 6. http://dx.doi.org/10.2165/00128415-201113350-00020.

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Pfitzner, Artur, Leo Polz, and Joachim Stöckigt. "Properties of Vinorine Synthase — the Rauwolfia Enzyme Involved in the Formation of the Ajmaline Skeleton." Zeitschrift für Naturforschung C 41, no. 1-2 (1986): 103–14. http://dx.doi.org/10.1515/znc-1986-1-217.

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Abstract Vinorine synthase, a key enzyme in the formation of the Rauwolfia alkaloid ajmaline and its derivatives, has been isolated from Rauwolfia serpentina cell suspension cultures. The new enzy­me has been 160-fold purified and characterized in detail. The synthase catalyses a single step in the biosynthesis of ajmalan alkaloids by the acetyl-coenzyme A and 16-epi-vellosimine dependent formation of vinorine, which shows the basic ajmaline skeleton. Besides a characteristic substrate specificity the major properties of the enzyme are a relatively high pH optimum (pH 8.5), a temperature optim
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&NA;. "Ajmaline/isoprenaline." Reactions Weekly &NA;, no. 1185 (2008): 5. http://dx.doi.org/10.2165/00128415-200811850-00014.

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Thapanasuta, Mananchaya, Ronpichai Chokesuwattanaskul, Pattranee Leelapatana, Voravut Rungpradubvong, and Somchai Prechawat. "T-Peak to T-End Interval for Prediction of Positive Response to Ajmaline Challenge Test in Suspected Brugada Syndrome Patients." Medical Sciences 10, no. 4 (2022): 69. http://dx.doi.org/10.3390/medsci10040069.

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Background: Brugada syndrome (BrS) is diagnosed in patients with ST-segment elevation with coved-type morphology in the right precordial leads, occurring spontaneously or after provocative drugs. Due to electrocardiographic (ECG) inconsistency, provocative drugs, such as sodium-channel blockers, are useful for unmasking BrS. Ajmaline is superior to flecainide and procainamide to provoke BrS. Prolonged T-peak to T-end (TpTe) is associated with an increased risk of ventricular arrhythmia and sudden cardiac death in Brugada syndrome patients. Objective: This study aimed to investigate the predict
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Hollman, A. "Reserpine and ajmaline." Heart 66, no. 6 (1991): 434. http://dx.doi.org/10.1136/hrt.66.6.434.

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Singh, Dhruv, Bhavana Srivastava, and Archana Sahu. "Spectrophotometric determination of ajmaline and brucine by Folin Ciocalteu’s reagent." Journal of the Serbian Chemical Society 68, no. 8-9 (2003): 685–90. http://dx.doi.org/10.2298/jsc0309685s.

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Arapid and simple spectrophotometric procedure is described for the determination of ajmaline and brucine. The method is based on the development of blue colored product due to reduction of tungstate and/or molybdate in Folin Ciocalteu?s reagent (FCR) by ajmaline and brucine in alkaline medium. The color is stable for more than 48 h. The chromogenic reaction has ?max at 540 nm with molar absorptivity 1.64 x 104 and 2.37 x 103 l mol-1 cm-1 in the Beer?s law range 1?8 ?g ml-1 and 10?100 ?g ml-1 for ajmaline and brucine, respectively.
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Monali, V. Chavan* Prof. Poonam P. Khade Dr. Megha T. Salve. "Utilization Of Radix Rauwolfia As Therapeutic Agent: A Comprehensive Review." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 293–300. https://doi.org/10.5281/zenodo.10136807.

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Rauwolfia serpentina is an important medicinal plant in the pharmaceutical world due to the presence of its immense therapeutic properties. The plant is known for curing various disorders because of the presence of alkaloids, carbohydrates, flavonoids, glycosides, phlobatannins, phenols, resins, saponins sterols, tannins and terpenes. The plant parts, root and rhizome have been used since centuries in Ayurvedic medicines for curing a large number of diseases such as high blood pressure, mental agitation, epilepsy, traumas, anxiety, excitement, schizophrenia, sedative insomnia and insanity. The
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Veltmann, C., C. Wolpert, F. Sacher, et al. "Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges." Europace 11, no. 10 (2009): 1345–52. http://dx.doi.org/10.1093/europace/eup189.

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Dissertations / Theses on the topic "Ajmaline"

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Cresswell, Mark. "The stereoselective Pictet-Spengler reaction and studies towards the total synthesis of ajmaline." Thesis, Keele University, 2013. http://eprints.keele.ac.uk/3816/.

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Due to their extensive and important medicinal properties, the indole alkaloids are an important class of natural products. A key step towards the total synthesis of indole alkaloids is the diastereoselective Pictet-Spengler reaction, which has enabled the total syntheses of a number of these natural products to be reported, one of which is the medicinally-important alkaloid ajmaline. Ajmaline is well studied and the previous attempts towards its synthetic preparation are described. During our investigations towards the asymmetric syntheses of ajmaline and other related indole alkaloids, it wa
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Hill, Marco [Verfasser]. "Charakterisierung zentraler Enzyme des Ajmalin-Biosynthesewegs aus Rauvolfia serpentina / Marco Hill." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2007. http://d-nb.info/1225402115/34.

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Schumann, Gerald v. "Isolierung, Reinigung und Expression zentraler Enzyme der Biosynthese des pflanzlichen Antiarrhythmikums Ajmalin." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=96890873X.

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Majerus, Florence. "Production d'alcaloides par des suspensions de catharanthus roseus : mise en oeuvre de cellules immobilisées dans un gel d'alginate." Toulouse, INSA, 1986. http://www.theses.fr/1986ISAT0046.

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Des limitations nutritionnelles, provoquees par une diminution des concentrations en acide 2,4 dichlorophenoxyacetique et en ions phosphates, entrainent un ralentissement de croissance suffisant pour maintenir la stabilite du ploymere d'inclusion de cellules de catharanthus roseus. Simultanement, une stimulation de la synthese d'ajmalicine est observee. Dans ces conditions, l'immobilisation des cellules dans l'alginate stabilise leur activite metabolique sur une periode d'au moins 600 heures. La production specifique d'ajmalicine atteint alors 970mug/sec et est multipliee d'un facteur 50 par r
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Schumann, Gerald v. [Verfasser]. "Isolierung, Reinigung und Expression zentraler Enzyme der Biosynthese des pflanzlichen Antiarrhythmikums Ajmalin / vorgelegt von Gerald v. Schumann." 2003. http://d-nb.info/96890873X/34.

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Thakore, Dhara. "Mass propagation of hairy root culture of catharanthus roseus in a bioreactor for ajmalicine production." Thesis, 2014. http://localhost:8080/xmlui/handle/12345678/6683.

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Books on the topic "Ajmaline"

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Obitz, Peter. Enzyme der Ajmalin-Biosynthese aus Zellkulturen von Rauwolfia serpentina: Reinigung, Charakterisierung und molekularbiologische Bearbeitung. [s.n.], 1995.

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Falkenhagen, Heike. Die Vinorin-Hydroxylase: Ein membrangebundenes Schlusselenzym der Ajmalin-Biosynthese. 1995.

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Schillinger, Bärbel. Untersuchung Ajmalin- und Chinuclidinol-bindender membranständiger Proteine im Molekulargewichtsbereich zwischen 48000 und 51000. 1995.

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Book chapters on the topic "Ajmaline"

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Yang, Zhi-Hong, Shou-Bao Wang, and Guan-Hua Du. "Ajmaline." In Natural Small Molecule Drugs from Plants. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8022-7_1.

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Joule, John A. "The Sarpagine-Ajmaline-Akuammiline Group." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186954.ch5.

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Kunakh, V. A., and E. G. Alkhimova. "Rauwolfia serpentina: In Vitro Culture and the Production of Ajmaline." In Medicinal and Aromatic Plants II. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73617-9_22.

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Petcaru, Natalia. "Ajmaline, Flecainide and Propafenone Can Induce Ventricular Fibrillation in Patients with Brugada Syndrome." In Arrhythmia Induction in the EP Lab. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-92729-9_18.

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Goel, M. K., S. Mehrotra, A. K. Kukreja, K. Shanker, and S. P. S. Khanuja. "In Vitro Propagation of Rauwolfia serpentina Using Liquid Medium, Assessment of Genetic Fidelity of Micropropagated Plants, and Simultaneous Quantitation of Reserpine, Ajmaline, and Ajmalicine." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-287-2_2.

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Wellens, Hein J. J., Frits W. Bär, Anton P. Gorgels, and Eduard J. Vanagt. "Use of ajmaline in patients with the Wolff-Parkinson-White syndrome to disclose short refractory period of the accessory pathway." In Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4110-9_20.

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Trappe, H. J., H. Klein, and P. R. Lichtlen. "Akutbehandlung der stabilen Kammertachykardie: Ajmalin oder andere spezifische Antiarrhythmika?" In Aspekte der medikamentösen Behandlung von Herzrhythmusstörungen. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-93403-2_11.

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Manz, M., and B. Lüderitz. "Vergleichende Untersuchung von Ajmalin und Lidocain bei ventrikulären Tachyarrhythmien." In Perspektiven der Arrhythmiebehandlung. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73422-9_10.

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Kleinsorge, H. "Zur Geschichte der Antiarrhythmika — unter besonderer Berücksichtigung von Ajmalin." In Arrhythmiebehandlung und Hämodynamik. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75335-0_2.

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Renaudin, Jean-Pierre, and Jean Guern. "Ajmalicine Transport into Vacuoles Isolated from Catharanthus Roseus Cells." In Plant Vacuoles. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5341-6_45.

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Conference papers on the topic "Ajmaline"

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Romero Legarreta, I., S. Bauer, R. Weber dos Santos, H. Koch, and M. Bar. "Spatial properties and effects of ajmaline for epicardial propagation on isolated rabbit hearts: Measurements and a computer study." In 2007 34th Annual Computers in Cardiology Conference. IEEE, 2007. http://dx.doi.org/10.1109/cic.2007.4745435.

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Byrne, L., D. Crinion, E. Keelan, et al. "50 Risk of ventricular arrythmia in ajmaline testing: significant variation identified in safety profile of the two most prevalent infusion protocols." In Irish Cardiac Society Annual Scientific Meeting & AGM, Thursday October 4th – Saturday October 6th 2018, Galway Bay Hotel, Galway, Ireland. BMJ Publishing Group Ltd and British Cardiovascular Society, 2018. http://dx.doi.org/10.1136/heartjnl-2018-ics.50.

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Sulaiman, HM, P. Brennan, H. Connolly, J. McOsker, T. Jardine, and A. Miur. "12 Comparison of slow vs. rapid ajmaline infusion protocol for the diagnosis of brugada syndrome (BrS): ten year experience of the Northern Ireland inherited cardiac conditions service (NI ICC)." In Irish Cardiac Society Annual Scientific Meeting & AGM (Virtual), October 7th – 9th 2021. BMJ Publishing Group Ltd and British Cardiovascular Society, 2021. http://dx.doi.org/10.1136/heartjnl-2021-ics.12.

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Phuc, Vo Thanh, Nguyen Minh Trung, Huynh Tri Thien, and Le Thi Thuy Tien. "Proliferation and ajmalicine biosynthesis of Catharanthus roseus (L). G. Don adventitious roots in self-built temporary immersion system." In INTERNATIONAL CONFERENCE ON CHEMICAL ENGINEERING, FOOD AND BIOTECHNOLOGY (ICCFB2017): Proceedings of the 3rd International Conference on Chemical Engineering, Food and Biotechnology. Author(s), 2017. http://dx.doi.org/10.1063/1.5000186.

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Xiang, Bei-Bei, Ye-Rong Zhu, Wen-Juan Wang, Yan-Ling Bai, and Yong Wang. "Notice of Retraction: Influence of Methyl Jasmonate on Cell Membrane Permeability and Ajmalicine Accumulation in Salt-Stressed Catharanthus roseus Suspension Cells." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780235.

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