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Relevant bibliographies by topics / ALK2

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Academic literature on the topic 'ALK2'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "ALK2"

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Ungefroren, Hendrik, Rüdiger Braun, Olha Lapshyna та ін. "Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b". Biomedicines 10, № 10 (2022): 2640. http://dx.doi.org/10.3390/biomedicines10102640.

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Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and ALK2, that transmit downstream signals of the TGFβ via different Smad proteins, SMAD2/3 and SMAD1/5, respectively, poses the issue of their relative contribution in regulating cell motility. Real-time cell migration assays revealed that the selective inhibition of ALK2 by RNAi or dominant-negative interference with a kinase-dead mutant (ALK2-K233R) strongly enhanc

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Steinbicker, Andrea U., Claire Mayeur, Lisa K. Lohmeyer, et al. "Alk3, a BMP Type I Receptor Is Required for the Induction of Hepatic Hepcidin Gene Expression by Interleukin-6." Blood 118, no. 21 (2011): 686. http://dx.doi.org/10.1182/blood.v118.21.686.686.

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Abstract Abstract 686 Introduction: Anemia of chronic disease (ACD), the second most prevalent form of anemia, is commonly associated with chronic inflammatory, infectious, or neoplastic conditions. ACD is characterized by high hepcidin levels that decrease serum iron levels by inducing degradation of the iron exporter ferroportin. In contrast, a relative deficiency of hepcidin leads to ferroportin overexpression and iron overload. Hepcidin is transcriptionally regulated by interleukin-6 (IL-6) and bone morphogenic protein (BMP) signaling. Binding of BMP ligands to type II and type I BMP recep

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Olsen, Oddrun Elise, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert та Toril Holien. "Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors". Biomolecules 10, № 4 (2020): 519. http://dx.doi.org/10.3390/biom10040519.

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Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the bone morphogenetic protein (BMP) receptor ALK2, causing activation of the SMAD1/5/8 pathway. In this study, we aimed to dissect how activin A and activin B homodimers, and activin AB and AC heterodimers activate the two main SMAD branches. We compared the activin-induced signaling dynamics of ALK4/7-SMAD2/3 and ALK2-SMAD1/5 in a multiple myeloma cell line. Signaling via the AL

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Backus, Thomas A., Natalia Medeiros, Evan Lema, Ffolliott Fisher, Jasbir Seehra, and Jennifer Lachey. "Selective Inhibition of ALK2 Signaling Suppresses Serum Hepcidin and Increases Serum Iron." Blood 136, Supplement 1 (2020): 14. http://dx.doi.org/10.1182/blood-2020-139486.

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Hepcidin is an endocrine regulator of iron metabolism that, when elevated, can decrease levels of iron available for erythropoiesis and, as a result, decrease red blood cell production. Signaling though activin-like kinase-2 (ALK2), a TGFβ type 1 receptor, has been implicated in regulation of hepcidin-mediated iron regulation and mobilization; however, to date, ALK2's specific degree of involvement has not been convincingly elucidated, mainly due to the redundant effects of the type 1 receptors ALK3 and ALK5. Activation of type 1 receptors including ALK2, ALK3, and ALK5 via ligand BMPs and co-

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Steinbicker, Andrea U., Thomas B. Bartnikas, Lisa K. Lohmeyer, et al. "Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice." Blood 118, no. 15 (2011): 4224–30. http://dx.doi.org/10.1182/blood-2011-03-339952.

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Abstract Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iron overload disorders, collectively termed hereditary hemochromatosis. Conversely, chronic inflammatory conditions and neoplastic diseases can induce high hepcidin levels, leading to impaired mobilization of iron stores and the anemia of chronic disease. Two BMP type I receptors, Alk2 (Acvr1

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Brederlau, A., R. Faigle, M. Elmi, et al. "The Bone Morphogenetic Protein Type Ib Receptor Is a Major Mediator of Glial Differentiation and Cell Survival in Adult Hippocampal Progenitor Cell Culture." Molecular Biology of the Cell 15, no. 8 (2004): 3863–75. http://dx.doi.org/10.1091/mbc.e03-08-0584.

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Bone morphogenetic proteins (BMPs) act as growth regulators and inducers of differentiation. They transduce their signal via three different type I receptors, termed activin receptor-like kinase 2 (Alk2), Alk3, or bone morphogenetic protein receptor Ia (BMPRIa) and Alk6 or BMPRIb. Little is known about functional differences between the three type I receptors. Here, we have investigated consequences of constitutively active (ca) and dominant negative (dn) type I receptor overexpression in adult-derived hippocampal progenitor cells (AHPs). The dn receptors have a nonfunctional intracellular but

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Zhang, Han, Christian Klausen, Hua Zhu, Hsun-Ming Chang, and Peter C. K. Leung. "BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD4 in Human Granulosa-Lutein Cells." Endocrinology 156, no. 11 (2015): 4269–80. http://dx.doi.org/10.1210/en.2015-1494.

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Adequate production of progesterone by the corpus luteum is critical to the successful establishment of pregnancy. In animal models, bone morphogenetic protein (BMP) 4 and BMP7 have been shown to suppress either basal or gonadotropin-induced progesterone production, depending on the species examined. However, the effects of BMP4 and BMP7 on progesterone production in human granulosa cells are unknown. In the present study, we used immortalized (SVOG) and primary human granulosa-lutein cells to investigate the effects of BMP4 and BMP7 on steroidogenic acute regulatory protein (StAR) expression

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Dulja, Alessandro, Alessia Pagani, Mariateresa Pettinato, Antonella Nai, Clara Camaschella, and Laura Silvestri. "The Immunophilin FKBP12 Inhibits Hepcidin By Modulating BMP Type I-Type II Receptors Interaction and Ligand Responsiveness." Blood 134, Supplement_1 (2019): 430. http://dx.doi.org/10.1182/blood-2019-130058.

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Introduction The liver hormone hepcidin is the master regulator of iron metabolism that modulates iron release into the circulation by binding and blocking the iron exporter ferroportin (Nemeth et al., 2004). Hepcidin expression is under the control of the BMP-SMAD pathway (Babitt et al., 2006), whose activation requires the formation of a hexameric complex composed of a dimer of BMP receptors type I (BMPR-Is), a dimer of BMPR type II (BMPR-IIs) and dimeric ligands. ALK2 and ALK3, as BMPR-Is (Steinbiecker et al., 2011), BMPR2 and ACVR2A, as BMPR-IIs (Mayeur et al., 2014), and BMP2 (Koch et al,

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Pagani, Alessia, Mariateresa Pettinato, Alessandro Dulja, et al. "Dissecting the Mechanisms of Hepcidin and BMP-SMAD Pathway Regulation By FKBP12." Blood 138, Supplement 1 (2021): 2008. http://dx.doi.org/10.1182/blood-2021-152172.

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Abstract The BMP-SMAD pathway is activated when a dimeric ligand (BMP) interacts with a dimeric serine threonine kinase receptor (BMPRII) and triggers the activation of a dimeric BMP type I receptor (BMPRI). Catalytically active BMPRIs phosphorylate SMAD1/5/8 that, upon SMAD4 binding, translocate to the nucleus to regulate the expression of BMP target genes, including hepcidin. Hepcidin is the main regulator of iron homeostasis that controls body iron levels by binding and blocking the sole iron exporter ferroportin. In agreement, hepcidin expression is homeostatically activated by serum and l

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Chen, Yaoyu, Matthew C. Stubbs, Michelle Pusey, et al. "Characterization of INCB00928, a Potent and Selective ALK2 Inhibitor for the Treatment of Anemia." Blood 136, Supplement 1 (2020): 52. http://dx.doi.org/10.1182/blood-2020-136138.

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A significant population of patients with myelofibrosis (MF) develop anemia and either require red blood cell (RBC) transfusions or have an inadequate response to the currently available therapies and become transfusion-dependent. In patients with MF, elevated levels of serum hepcidin, a key iron regulatory hormone, is associated with increased dependence on RBC transfusions and reduced overall survival. Elevated hepcidin expression has also been observed to cause severe functional iron deficiency anemia and is central to the pathophysiology of anemia of chronic disease. Thus, to ensure proper

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Dissertations / Theses on the topic "ALK2"

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Hildebrandt, Susanne [Verfasser]. "Generation of induced Pluripotent Stem Cell derived Endothelial Cells from Fibrodysplasia Ossificans Progressiva patients - a disease model of ActivinA and BMP-induced ALK2 receptor activation / Susanne Hildebrandt." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1233286528/34.

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Arai, Hiroyuki. "Metalloprotease-dependent attenuation of BMP signaling restricts cardiac neural crest cell fate." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245816.

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京都大学<br>0048<br>新制・論文博士<br>博士(医学)<br>乙第13301号<br>論医博第2190号<br>新制||医||1039(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授妻木範行, 教授木村剛, 教授影山龍一郎<br>学位規則第4条第2項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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Dos, Santos Curado Filipa. "The role of ALK1 and ALK5 receptors, and their cognate Smads, in TGFβ1-mediated podosome-formation in aortic endothelial cells". Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22040.

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Le TGF-β (Transforming growth factor-β) régule de nombreux processus cellulaires et la dérégulation de la signalisation du TGF-β est associée à divers troubles vasculaires. Dans le laboratoire du Dr Génot, le TGF-β a été découvert comme étant le facteur capable d’induire la formation de podosomes organisés en superstructures, appelées rosettes, dans les cellules endothéliales aortiques. Les podosomes sont des structures à base d’actine, formées de façon transitoire, capables de dégrader la matrice extracellulaire (MEC). Dans ce projet, nous avons étudié les récepteurs du TGF-β et les mécanisme

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Morazzo, Sofia Faes. "A potencial função do nodal na endometrose da égua." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/14039.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Alguns membros da superfamília do TGFβ, tais como o Nodal e o TGFβ1, têm um papel importante na reprodução da égua, sendo que a sua disfunção pode contribuir para patologias uterinas. A endometrose é uma doença degenerativa em que o endométrio normal vai sendo substituído por tecido fibrótico. O objectivo deste estudo consistiu em avaliar: (i) como o Nodal pode influenciar o nível de mRNA dos recetores da PGE2 (EP2; EP4), do TGFβ1 (ALK5; TGFRII), e os próprios (ALK4; ALK7), e ainda, a secreção de prostaglandinas (PGs; PGE2; PGF2α) no

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CECCON, MONICA. "Crizotinib-resistan NPM-ALK mutants confer differential sensitivity to unrelated alk inhibitors." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/42060.

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The dual ALK/MET inhibitor Crizotinib was recently approved for the treatment of metastatic and late stage ALK+ NSCLC, and is currently in clinical trial for other ALK‐related diseases. As predicted after other TKIs clinical experience, the first mutations that confer resistance to Crizotinib have been described in Non Small Cell Lung Cancer (NSCLC) and in one Inflammatory Myofibroblastic Tumor (IMT) patients. Here we focused our attention on Anaplastic Large Cell Lymphoma (ALCL), where the oncogenic fusion protein NPM-ALK, responsible for 70-80% of cases, represents an ideal Crizotinib target

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Althini, Susanna. "Experimental Studies of BMP Signalling in Neuronal Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3398.

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Tudor, Elizabeth Lilian. "Cellular and molecular studies of alsin/ALS2." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424369.

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Jugold, Alke [Verfasser]. "Abiotic methane formation in oxic soils / Alke Jugold." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1033733792/34.

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Heuckmann, Johannes [Verfasser], Ralf [Akademischer Betreuer] Küppers, and Roman [Akademischer Betreuer] Thomas. "Different EML4-ALK fusion variants and novel ALK resistance mutations induce differential sensitivity to ALK kinase inhibitors / Johannes Heuckmann. Gutachter: Roman Thomas. Betreuer: Ralf Küppers." Duisburg, 2013. http://d-nb.info/1041831811/34.

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Heuckmann, Johannes Martin [Verfasser], Ralf [Akademischer Betreuer] Küppers, and Roman [Akademischer Betreuer] Thomas. "Different EML4-ALK fusion variants and novel ALK resistance mutations induce differential sensitivity to ALK kinase inhibitors / Johannes Heuckmann. Gutachter: Roman Thomas. Betreuer: Ralf Küppers." Duisburg, 2013. http://nbn-resolving.de/urn:nbn:de:hbz:464-20130903-110535-7.

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Books on the topic "ALK2"

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Boris, Ljubčić, ed. Alka. Viteško alkarsko društvo, 2001.

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Buela, Alvaro. Alka-Seltzer. Cal y Canto, 1994.

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Arsiḱ, Stojan. Poslednata alka. Akademski pečat, 2013.

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Radičeski, Naume. Slovenska alka. Makedonika litera, 2012.

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Shesh, Shankar. Khajurtaho ki Alka. Kitabghar, 1990.

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Sánta, György. Az alku: Naplóregény. Papirusz Book, 2012.

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Shesh, Shankar. Khajuraho ki alka. [s.n.], 1990.

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Jovanović, Dušan. Klinika Kozarcky: Alko-komedija. Slovensko stalno gledališče, 1999.

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Suhonen, Pekka. Artek: Alku, tausta, kehitys. Frenckell Espoo, 1985.

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Härkönen, Ritva-Sini. Aikakauslehti koululuokassa: Alku viestintäkasvatukselle? Valtion painatuskeskus, 1988.

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Book chapters on the topic "ALK2"

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Maruyama, Rika, and Toshifumi Yokota. "Morpholino-Mediated Exon Skipping Targeting Human ACVR1/ALK2 for Fibrodysplasia Ossificans Progressiva." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8651-4_32.

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Martin, Andrew P., and Justin D. Topp. "ALS2." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101505.

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Martin, Andrew P., and Justin D. Topp. "ALS2." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101505-1.

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Guelachvili, G. "91 AlN2 (NAlN)." In Linear Triatomic Molecules. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-74187-9_24.

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Peyma, Nasser Dasht. "Joshi, Alka (1958–)." In Encyclopedic Dictionary of Diasporic Indian English Writing. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-96-0045-8_153.

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Donà, Riccardo, Konstantinos Mattas, Giovanni Albano, Sandor Váss, and Biagio Ciuffo. "Towards Automated Driving: Findings and Comparison with ADAS." In Lecture Notes in Mechanical Engineering. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-70392-8_134.

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AbstractThe present contribution provides preliminary empirical findings concerning the first-in-literature independent experimental characterization of a commercially viable automated driving system in Europe. In particular, the paper reports on the testing campaign involving a type-approved Automated Lane Keeping System (ALKS) equipped vehicle and its comparison with the comparable driving assistance feature technology from the same vehicle: the Adaptive Cruise Control (ACC) system. The results suggest that the ALKS shows substantially enhanced performances with respect to ACC. In particular

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Hasson, Brian F., Charlie Ma, Lu Wang, et al. "ALK Inhibitors." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_738.

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Pulford, Karen. "ALK Protein." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_179-5.

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Pulford, Karen. "ALK Protein." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-46875-3_179.

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Pulford, Karen. "ALK Protein." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_179.

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Conference papers on the topic "ALK2"

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Yann, Theara, Charinee Winotapun, Phanny Yos, Lee Hwei Voon, and Orathai Boondamnoen. "Particle Characteristics of Diatomite Activated by Alkaline Solution." In 2024 8th International Conference on Materials Engineering and Nano Sciences & 2024 8th International Conference on Material Engineering and Manufacturing. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-d4jwe2.

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In this study, the activation of natural diatomite was done with alkaline solution. The diatomite powder was sieved and purified prior to activation at room temperature (Alk-DA RT) and 85 °C (Alk-DA 85 °C). The effect of activation time of Alk-DA 85 °C samples was observed for 1 h, 2 h and 5 h. At temperature interval from room temperature to 530 °C, the weight loss for all of Alk-DA are less than R-DA. The reduction of particle aggregation was found in Alk-DA at both RT and 85 °C as shown in SEM images, indicating the activation by NaOH that effectively breaks down the bulky structure. The fo

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Peñuela, Leomar, and Jose Chirinos. "Carbon Steel Flanges and Welds Evaluation on HF-Alkylation Unit." In CORROSION 1999. NACE International, 1999. https://doi.org/10.5006/c1999-99381.

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Abstract In 1995, there were two failures in the 20.000 BPD HF Alky unit at the Amuay Refinery causing a shutdown of the unit. The failures occurred in one flange and one weld in the depropanizer charge carbon steel pipe, containing propane, isobutane and anhydrous hydrofluoric acid at 190 F (88 C) and 321 psig (22.5 Kg/cm2). Examination showed severe uniform corrosion at the inside surface of the flange while the adjacent elbow showed minimal corrosion loss. The other failure showed preferential attack in the weld without corrosion loss in the pipe components. A complete evaluation of the Alk

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Lunder, Otto, John Erik Lein, Terje Kr Aune, and Kemal Nisancioglu. "The Role of Mg1>Al12 Phase in the Corrosion of Mg Alloy AZ91." In CORROSION 1988. NACE International, 1988. https://doi.org/10.5006/c1988-88049.

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Abstract Corrosion behavior of mould-cast Mg alloy AZ91 is investigated in as-cast (F), homogenized (T4), and artificially-aged (T6) conditions in chloride media. Heat treatment influences mainly the distribution of intermetallic β -phase (Mg1&gt;Al12) in the alloy. Aging to T6 temper causes precipitation of the phase as a nearly continuous network of secondary particles along the grain boundaries. The alloy exhibits much better corrosion resistance in the T6 temper than it does in the other two conditions. It is observed that the β -phase is inert to the chloride solution in comparison to

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Peterson, Peter W. "Abstract 3647: Targeting cancer-induced anemia with hepcidin lowering ALK2 inhibitors." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3647.

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Benderitter, Pascal, Josselin Caradec, Edwige Nicodeme, Anne Bouillot, Sophie Vaulont, and Benoit Viollet. "Abstract 4028: Nanocyclix®ALK2 Inhibitors to overcome cancer-induced anemia." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-4028.

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Shen, H., Y. Gao, T. Y. W. Wei, J. X. Yuan, K. Gong, and J. Y. Shyy. "BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3124.

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David, Vollmer, Jared Bearss, Carissa Jones, et al. "Abstract C206:In vivoactivity of SGI‐1252, a potent, small‐molecule dual inhibitor of JAK2 and ALK2." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c206.

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Stephens, Bret J., Alexis Mollard, Lingyao Meng, David J. Bearss, and Steven L. Warner. "Abstract 904: TP-0413 is a dual-specific inhibitor against Jak2 and Alk2 with therapeutic potential for treating anemia of chronic disease." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-904.

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Wei, Ping, Ming Qiu, Nathan Lee, et al. "Abstract 764: Rational combination of PF-06463922 (next-generation ALK inhibitor) with PI3K pathway inhibitors overcomes ALKi resistance in EML4-ALK+ NSCLC models." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-764.

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Jakhotia, Sneha, Branislav Nastasijević, Gordana Joksić, Sreenivasa Reddy, and G. Bhanuprakash Reddy. "Gentiana lutea AND DIABETIC COMPLICATIONS." In 8th Workshop Food and Drug Safety and Qualit. Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, 2024. http://dx.doi.org/10.46793/8fdsq.ild1sj.

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Chronic hyperglycemia in diabetes leads to macro and microvascular complications. An increase in the aldose reductase (ALR2) activity, accumulation of sorbitol, accumulation of advanced glycation end-products (AGEs), and inflammation lead to cellular damage, ultimately resulting in complications. ALR2 inhibition has been a consideration to treat/manage diabetic complications, but most of the ALR2 inhibitors are not free of side effects. As a part of our work to find better ALR2 inhibitors, we found that extracts of Gentiana lutea exhibited ALR2 inhibitory potential in vitro. We have also disco

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Reports on the topic "ALK2"

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Mawassi, Munir, and Valerian V. Dolja. Role of the viral AlkB homologs in RNA repair. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594396.bard.

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AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB functions in the viral infection cycle using a range of complementary genetic and biochemical approaches. Our hypotheses was that AlkB is required for efficient replication and genetic stability of viral RNA genomes The major objectives of the r

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Harrison, W. T., G. D. Stucky, R. E. Morris, and A. K. Cheetham. The Synthesis and Crystal Structure of Aluminum Selenite Trihydrate, Al2(seO3)3.32O. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada251283.

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Sassi, Michel JPC, David Senor, and Andrew Casella. Ab Initio Simulations of Tritium Diffusion in Al2O and Intermetallic Al12(TM)2.34 Aluminide Coating Phases. Office of Scientific and Technical Information (OSTI), 2023. http://dx.doi.org/10.2172/2001006.

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George, Rani E. A Genetically Engineered Mouse Model of Neuroblastoma Driven by Mutated ALK and MYCN. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613947.

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Raber, Jacob, and Tessa Marzulla. Effects of Pharmacologic and Genetic Inhibition of Alk on Cognitive Impairments in NF1 Mutant Mice. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada606392.

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Mawassi, Munir, and Valerian Dolja. Role of RNA Silencing Suppression in the Pathogenicity and Host Specificity of the Grapevine Virus A. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7592114.bard.

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Abstract:

RNA silencing is a defense mechanism that functions against virus infection and involves sequence-specific degradation of viral RNA. Diverse RNA and DNA viruses of plants encode RNA silencing suppressors (RSSs), which, in addition to their role in viral counterdefense, were implicated in the efficient accumulation of viral RNAs, virus transport, pathogenesis, and determination of the virus host range. Despite rapidly growing understanding of the mechanisms of RNA silencing suppression, systematic analysis of the roles played by diverse RSSs in virus biology and pathology is yet to be completed

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Kretzschmar, Marcus, and Hans-Willem Snoeck. Analysis of Alk-1 Signaling in Endothelial Cells and its Role in Breast Tumor Angiogenesis. Addendum. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada477666.

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Xing, Puyuan, Xuezhi Hao, Xin Zhang, and Junling Li. Efficacy and safety of brigatinib in ALK-positive non-small cell lung cancer treatment: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.3.0142.

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Zhao, Binghao, and Yan Han. Efficacy and safety of therapies for ALK-positive non-small cell lung cancer with brain metastasis: a Bayesian network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.1.0056.

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Lin, Kehai, Jie Lin, Kunpeng Du, et al. Smoking status in the first line treatment of advanced ALK-positive non-small cell lung cancer : a Bayesian network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.8.0009.

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