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Journal articles on the topic 'Alkaloid synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Han, Sunkyu, Sangbin Jeon, and Joonoh Park. "Syntheses of Dimeric Securinega Alkaloids." Synlett 28, no. 18 (2017): 2353–59. http://dx.doi.org/10.1055/s-0036-1590864.

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The isolation of flueggenines A and B by Yue and co-workers in 2006 has triggered a burst of isolation reports of dimeric and oligomeric securinega alkaloid natural products. The compelling molecular structures of these compounds with various modes of connection between monomeric securinega units have posed intriguing challenges to the synthetic organic community. Herein, we have categorized high-order securinega alkaloids based on their biosynthetic mode of dimerization or oligomerization. We then have compiled all reported syntheses of dimeric securinega alkaloids based on our classification

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2

Dewan, S. Bhakuni. "Biosynthesis and synthesis of biologically active alkaloids of Indian medicinal plants." Journal of Indian Chemical Society Vol. 79, Mar 2002 (2002): 203–10. https://doi.org/10.5281/zenodo.5840849.

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Central Drug Research Institute, Lucknow-226 001, India <em>E-mail :</em>Root@cdrilk.Sirnetd.ernet.in               <em>Fax : </em>91-0522-223405/223938 The structure and stereochemistry of biologically active alkaloids isolated from <em>Croton sparsiflorus, Cocculus laurifolius, C. pendulus, Corydalis meifolia </em>and <em>Stephania glabra </em>were established. Biosynthetic studies were carried out on proaporphine and dihydroproaporphgne alkaloids, crotsparine and crotsparinine, and abnormal aporphine alkaloid sparsiflorine; abnormal <em>Eryt

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3

Enders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.

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Recent advances in the diastereo- and enantioselective synthesis of piperidine, pyrrolidine, and indolizidine alkaloids, based on the highly stereoselective 1,2-addition to the CN double bond of chiral aldehyde-SAMP/RAMP hydrazones, are described. The enantioselective syntheses of the pyrrolidine alkaloids bgugaine and (2S,12¢R)-2-(12¢-aminotridecyl)-pyrrolidine, a defense alkaloid of the Mexican bean beetle are reported. Furthermore, the SAMP/RAMP-hydrazone method was applied to the syntheses of two 5,8-disubstituted indolizidine alkaloids that have been extracted from neotropical poison-dart

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4

Giannis, Athanassios, Farnoush Mousavizadeh, and Daniel Meyer. "Synthesis of C-Nor-D-homo-steroidal Alkaloids and Their Derivatives." Synthesis 50, no. 08 (2018): 1587–600. http://dx.doi.org/10.1055/s-0036-1591965.

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The C-nor-D-homo-steroidal alkaloid cyclopamine was discovered in the 1969 and in 2000 it was shown to act as an inhibitor of the hedgehog signaling (Hh) pathway, which is aberrantly activated in some tumors. Subsequently it was revealed that this natural occurring alkaloid has also antidiabetic and antiviral properties. In this review we present syntheses of selected C-nor-D-homo-steroidal alkaloids and their analogues and also discuss a general access to C-nor-D-homo-steroids. Some historical as well as biomedical aspects are also presented.1 Introduction2 Total Synthesis of Cyclopamine2.1 S

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5

Zhang, Ye, Lei Zhang, and Xiangbing Qi. "Total Synthesis of (–)-Alstofolinine A: Selected Furan Oxidation/ Cyclization Cascade." Synlett 31, no. 01 (2019): 7–12. http://dx.doi.org/10.1055/s-0039-1690247.

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Indole-fused tetracyclic ring systems containing nitrogen atoms are common core skeletons of many indole alkaloids such as sarpagine, macroline, and ajmaline. Efficient and stereoselective construction of these ring systems can promote the development of the corresponding alkaloid syntheses. In this article, we briefly summarize our current progress toward the application of the aza-Achmatowicz reaction and indole nucleophilic addition reaction cascade for the first asymmetric total synthesis of the macroline-type indole alkaloid (–)-Alstofolinine A. Our synthetic strategy is based on furan ox

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6

Wink, Michael, and Ludger Witte. "Cell-Free Synthesis of the Alkaloids Ammodendrine and Smipine." Zeitschrift für Naturforschung C 42, no. 3 (1987): 197–204. http://dx.doi.org/10.1515/znc-1987-0304.

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The bipiperidyl alkaloid ammodendrine was detected in 28 plant species as a minor alkaloid besides quinolizidine alkaloids. Cadaverine serves as a precursor for both quinolizidine alkaloids and for ammodendrine, since labelled cadaverine is incorporated into both rings of ammodendrine. Cell-free extracts of Lupinus arboreus and of Pisum sativum, which contain an active diamine oxidase form ammodendrine from cadaverine and pyruvate. In addition to ammodendrine other alkaloids such as smipine, tetrahydroanabasine and tripiperideine could be detected. Possible reaction schemes are discussed.

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7

Chen, Bi-Shuang, Di Zhang, Fayene Zeferino Ribeiro de Souza, and Lan Liu. "Recent Advances in the Synthesis of Marine-Derived Alkaloids via Enzymatic Reactions." Marine Drugs 20, no. 6 (2022): 368. http://dx.doi.org/10.3390/md20060368.

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Alkaloids are a large and structurally diverse group of marine-derived natural products. Most marine-derived alkaloids are biologically active and show promising applications in modern (agro)chemical, pharmaceutical, and fine chemical industries. Different approaches have been established to access these marine-derived alkaloids. Among these employed methods, biotechnological approaches, namely, (chemo)enzymatic synthesis, have significant potential for playing a central role in alkaloid production on an industrial scale. In this review, we discuss research progress on marine-derived alkaloid

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8

Li, Yong, Jian Li, Hanfeng Ding, and Ang Li. "Recent advances on the total synthesis of alkaloids in mainland China." National Science Review 4, no. 3 (2017): 397–425. http://dx.doi.org/10.1093/nsr/nwx050.

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AbstractAlkaloids are a large family of natural products that mostly contain basic nitrogen atoms. Because of their intriguing structures and important functions, they have long been popular targets for synthetic organic chemists. China's chemists have made significant progress in the area of alkaloid synthesis over past decades. In this article, selected total syntheses of alkaloids from research groups in mainland China during the period 2011–16 are highlighted.

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9

D’hooghe, Matthias, Hyun-Joon Ha, and Lingamurthy Macha. "Deployment of Aziridines for the Synthesis of Alkaloids and Their Derivatives." Synthesis 51, no. 07 (2019): 1491–515. http://dx.doi.org/10.1055/s-0037-1611715.

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Various (activated and non-activated) aziridines with diverse substitution patterns have been deployed successfully as starting materials for the synthesis of a wide variety of alkaloids via suitable functionalization and aziridine ring transformation. Alternatively, the preparation and interception of reactive aziridine intermediates has also been shown to constitute a valid approach toward alkaloid synthesis. This review summarizes aziridine-mediated syntheses of alkaloids, in which the aziridine is mobilized as either a substrate or an advanced synthetic intermediate.1 Introduction2 Alkaloi

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10

Ryan, Suzanne M., Kathleen D. DeBoer, and John D. Hamill. "Alkaloid production and capacity for methyljasmonate induction by hairy roots of two species in Tribe Anthocercideae, family Solanaceae." Functional Plant Biology 42, no. 8 (2015): 792. http://dx.doi.org/10.1071/fp15045.

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In addition to producing medicinally important tropane alkaloids, some species in the mainly Australian Solanaceous tribe Anthocercideae, sister to genus Nicotiana, are known to also contain substantial levels of the pyridine alkaloids nicotine and nornicotine. Here, we demonstrate that axenic hairy root cultures of two tribe Anthocercideae species, Cyphanthera tasmanica Miers and Anthocercis ilicifolia ssp. ilicifolia Hook, contain considerable amounts of both nicotine and nornicotine (~0.5–1% DW), together with lower levels of the tropane alkaloid hyoscyamine (<0.2% DW). Treatment of grow

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11

Mill, Sibel, and Claude Hootelé. "A revised structure for the piperidine alkaloid andrachamine." Canadian Journal of Chemistry 74, no. 12 (1996): 2434–43. http://dx.doi.org/10.1139/v96-272.

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A new method for the synthesis of trans-2,6-disubstituted piperidine derivatives is described. The transformation of cyclic α-methoxycarbamates 5 and 6 affords trans ketones 17 and 18. The synthesis of diols 1–4 from 17 and 18 has shown that the structure proposed in the literature for the piperidine alkaloid andrachamine is incorrect. A reexamination of the original spectral data of this alkaloid suggested that it is a meso 2,6-disubstituted piperidine derivative. Unambiguous syntheses of 23 and 24 and comparison with a sample of andrachamine have established that this alkaloid possesses stru

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12

Nikolic, Milan, and Sinisa Djordjevic. "Alkaloids in the pharmaceutical industry: Structure, isolation and application." Chemical Industry 57, no. 10 (2003): 471–78. http://dx.doi.org/10.2298/hemind0310471n.

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By the end of the 18th and the beginning of the 19th century a new era began in medicine, pharmaceutics and chemistry that was strongly connected with alkaloids and alkaloid drugs. Even before that it was known that certain drugs administered in limited doses were medicines, and toxic if taken in larger doses (opium, coke leaves, belladonna roots, monkshood tubers crocus or hemlock seeds). However, the identification, isolation and structural characterization of the active ingredients of the alkaloid drugs was only possible in the mid 20th century by the use of modern extraction equipment and

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13

Estévez, Juan C., M. Carmen Villaverde, Ramon J. Estévez, Julio A. Seuas, and Luis Castedo. "New total synthesis of phenanthrene alkaloids." Canadian Journal of Chemistry 68, no. 6 (1990): 964–68. http://dx.doi.org/10.1139/v90-151.

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We describe a new synthesis of phenanthrene alkaloids based on the photocyclization of stilbene compounds prepared by a simple, efficient new method. It allows the preparation of phenanthrene compounds with a primary amine group in their side chain. Keywords: alkaloid, phenanthrene, stilbene, photocyclization.

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14

Hájíček, Josef. "A Review on Recent Developments in Syntheses of the Post-Secodine Indole Alkaloids. Part I: The Primary Alkaloid Types." Collection of Czechoslovak Chemical Communications 69, no. 9 (2004): 1681–767. http://dx.doi.org/10.1135/cccc20041681.

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This first part of a planned review on developments in the field of total and formal total synthesis of the post-secodine indole alkaloids concentrates on primary alkaloid types. It reviews the synthesis of secodine, aspidospermane, pseudoaspidospermane and ibogane alkaloids; andranginine is also included. It covers the literature from 1992-1993 up to approximately May 2004. A review with 179 references.

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15

Shi, Yingbo, Haibing He, and Shuanhu Gao. "Recent advances in the total synthesis of gracilamine." Chemical Communications 54, no. 92 (2018): 12905–13. http://dx.doi.org/10.1039/c8cc07799a.

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Gracilamine belongs to the Amaryllidaceae alkaloid group and has a unique five-ring skeleton. This review will summarize the synthetic studies of gracilamine, and hopes to bring new inspiration to the research of Amaryllidaceae alkaloids.

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16

Mimi, Carolina Ovile, Iván De-la-Cruz-Chacón, Felipe Moura Araujo da Silva, Victor Cauan Rocha Roberto, and Gisela Ferreira. "Effect of Auxins on the Accumulation of Alkaloids in Ungrafted Annona emarginata (Schltdl.) H. Rainer and Annona emarginata (Schltdl.) H. Rainer Grafted with Annona atemoya Mabb." Molecules 30, no. 9 (2025): 2070. https://doi.org/10.3390/molecules30092070.

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Plant regulators, such as auxins, modulate the synthesis of specialized metabolites and aid in the bioprospection of molecules. Annona emarginata is known to produce antifungal alkaloids and serves as a rootstock for Annona atemoya. This study evaluated the effects of indoleacetic acid (IAA), indolebutyric acid (IBA), and naphthaleneacetic acid (NAA) applications on the accumulation of alkaloids in ungrafted A. emarginata and grafted with A. atemoya. Total alkaloids were analyzed by spectrophotometry, and alkaloid profiles were analyzed by DI-MS at 8, 14, and 20 days after treatments (DAT). Th

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17

Sha, C. K., S. J. Huang, C. M. Huang, A. W. Hong, and T. H. Jeng. "Anionic cyclization approach toward perhydroindoles. Total synthesis of montanine-type Amaryllidaceae alkaloids." Pure and Applied Chemistry 72, no. 9 (2000): 1773–76. http://dx.doi.org/10.1351/pac200072091773.

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Hexahydro-1H-indol-3-one can be used as a building block for alkaloid synthesis. Radical and anionic cyclization approaches toward this useful structure were developed. Approaches toward total synthesis of montanine-type Amaryllidaceae alkaloids using hexahydro-1H-indol-3-one as a key intermediate were studied.

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18

Lounasmaa, Mauri, Reija Jokela, Tuula Taipale, and Kari Ala-Kaila. "Heteroyohimbine Alkaloid Synthesis." HETEROCYCLES 24, no. 8 (1986): 2265. http://dx.doi.org/10.3987/r-1986-08-2265.

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19

Scheidt, Karl A., and Eric R. Miller. "Enantioselective Syntheses of Yohimbine Alkaloids: Proving Grounds for New Catalytic Transformations." Synthesis 54, no. 05 (2021): 1217–30. http://dx.doi.org/10.1055/a-1684-2942.

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AbstractThe total synthesis of bioactive alkaloids is an enduring challenge and an indication of the state of the art of chemical synthesis. With the explosion of catalytic asymmetric methods over the past three decades, these compelling targets have been fertile proving grounds for enantioselective bond forming transformations. These activities are summarized herein both to highlight the power and versatility of these methods and to instill future inspiration for new syntheses of these privileged natural products.1 Introduction2 Monoterpenoid Indole Alkaloids2.1 Corynanthe-Type MIAs3 Biosynth

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20

Bhattacharyya, Dipanjan. "The galbulimima alkaloids—a new frontier in alkaloid synthesis." Tetrahedron 67, no. 31 (2011): 5525–42. http://dx.doi.org/10.1016/j.tet.2011.04.074.

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21

HANS-JOACHIM, KNOLKER, and BAUERMEISTER MICHAEL. "Transition Metal Diene Complexes in Organic Synthesis. Part-17 1. Studies directed towards the Iron-mediated Synthesis of 2-Oxygenated Carbazole Alkaloids." Journal of Indian Chemical Society Vol. 71, June-Aug 1994 (1994): 345–53. https://doi.org/10.5281/zenodo.5895373.

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<em>Institut fur Organische Chemie, Universitat Karlsruhe, Richard-Willstatter-Allee. 76131 Karlsruhe, Germany Manuscript received 6 October 1993</em> We describe some studies directed towards the synthesis of 2-oxygenated carbazole alkaloids by iron-mediated oxidative coupling of 1,3-cyclohexadiene and the corresponding 3-oxygenated aryiamine derivative. The process involves a consecutive formation of a carbon-carbon bond via electrophilic aromatic substitution with an iron-complexed cyclohexadienylium cation and subsequent carbon-nitrogen bond formation via oxidative cyclisation. Using this

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22

Olaranont, Yanisa, Alyssa B. Stewart, Wisuwat Songnuan, and Paweena Traiperm. "Analysis of ergot alkaloid gene expression and ergine levels in different parts of Ipomoea asarifolia." PeerJ 13 (July 15, 2025): e19692. https://doi.org/10.7717/peerj.19692.

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Background Ergot alkaloids are renowned for their pharmacological significance and were historically attributed to fungal symbioses with cereal crops and grasses. Recent research uncovered a symbiotic relationship between the fungus Periglandula ipomoea and Ipomoea asarifolia (Convolvulaceae), revealing a new source for ergot alkaloid synthesis. While past studies have emphasized the storage of both the fungus and alkaloids in leaves and seeds, recent work has found they also occur in other plant parts. This study aimed to examine expression of the dmaW gene, which plays a crucial role in ergo

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23

Martin, Bruna Cavinatti, Ivan De-la-Cruz-Chacón, Carolina Ovile Mimi, et al. "Impact of External Sources of Indole Acetic Acid and 2,3,5-Triiodobenzoic Acid on Alkaloid Production and Their Relationships with Primary Metabolism and Antioxidant Activity in Annona emarginata (Schltdl.) H. Rainer." Plants 13, no. 18 (2024): 2637. http://dx.doi.org/10.3390/plants13182637.

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Annona emarginata is a native Brazilian species capable of producing at least ten alkaloids of ecological, agronomic, and pharmacological importance. Some studies have explored the effect of external phytoregulators on the production of alkaloids, including the effect of auxins, which, like alkaloids, derive from the shikimic acid pathway. Thus, this study aimed to evaluate how indole acetic acid (IAA) and its inhibitor 2,3,5-triiodobenzoic acid (TIBA) impact the production of alkaloids and the primary metabolism of A. emarginata, which brings advances in the understanding of the mechanisms of

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24

Chiba, Shunsuke, and Atsushi Kaga. "Synthesis of Tricyclic Marine Alkaloids, Cylindricines, Lepadiformines, Fasicularin, and Polycitorols: A Recent Update." Synthesis 50, no. 04 (2017): 685–99. http://dx.doi.org/10.1055/s-0036-1589521.

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Cylindricines, lepadiformines, and fasicularin are tricyclic marine alkaloids bearing perhydropyrrolo- and pyrido[2,1-j] frameworks having divergent chemical functionalities. They have been isolated from marine tunicates over the last two decades and found to have a range of cytotoxicity such as DNA-alkylating ability. Recently, polycitorols have emerged as a new member of this alkaloid family. Their unique structural features and biological activities have intrigued many researchers and challenged them in their synthesis. This review describes recent syntheses of the tricyclic alkaloids based

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25

Smolobochkin, Andrey, Almir Gazizov, Nikita Sidlyaruk, Nurgali Akylbekov, Rakhmetulla Zhapparbergenov, and Alexander Burilov. "Cyclic Imines and Their Salts as Universal Precursors in the Synthesis of Nitrogen-Containing Alkaloids." International Journal of Molecular Sciences 26, no. 1 (2024): 288. https://doi.org/10.3390/ijms26010288.

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Alkaloids are predominantly nitrogen-containing heterocyclic compounds that are usually isolated from plants, and sometimes from insects or animals. Alkaloids are one of the most important types of natural products due to their diverse biological activities and potential applications in modern medicine. Cyclic imines were chosen as starting compounds for the synthesis of alkaloids due to their high synthetic potential. Thus, this review summarizes the achievements in the synthesis of various alkaloids from cyclic imines, paying special attention to stereoselective methods used for their prepar

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26

Jiao, Lei, Ze-Xin Zhang, and Si-Cong Chen. "Asymmetric Total Synthesis of (+)-Minfiensine by an Asymmetric Cascade Cyclization Strategy." Synlett 28, no. 17 (2017): 2199–204. http://dx.doi.org/10.1055/s-0036-1589075.

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The Strychnos alkaloid minfiensine and a series of akuammiline alkaloids, such as vincorine, aspidophylline A, and picrinine, possess a common core skeleton, a 4a,9a-heterocycle-fused tetrahydrocarbazole. Efficient construction of this core structure in a highly enantioselective manner would facilitate the total synthesis of these alkaloids. In this article, we briefly summarize the established strategies for obtaining this core structure, together with the corresponding total-synthesis routes, and we describe our own effort on the development of a new strategy, the asymmetric cascade dearomat

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27

Denic, Marija, Polina Blagojevic, and Niko Radulovic. "Synthetic approaches to coniine and other 2-alkyl piperidines." Facta universitatis - series: Physics, Chemistry and Technology 11, no. 1 (2013): 1–26. http://dx.doi.org/10.2298/fupct1301001d.

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The first synthesis of coniine, a neurotoxic piperidine alkaloid found in poison hemlock (Conium maculatum L.), was performed back in 1886 by Ladenburg. Since that time, numerous different approaches to the synthesis of this and related alkaloids (2-alkylpiperidines) have been developed. Nowadays, the enantioselective/specific synthesis of coniine is taken as a paradigm of the usefulness of new chiral synthetic methodologies. This review aims to summarize and systematize recent progress in the synthesis of coniine and related compounds.

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28

Berkov, Strahil, Atanas Pavlov, Vasil Georgiev, et al. "Alkaloid Synthesis and Accumulation in Leucojum Aestivum in Vitro Cultures." Natural Product Communications 4, no. 3 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400328.

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The alkaloids of intact plants, calli and shoot-clump cultures of L. aestivum were analyzed by GC-MS. Twenty-four alkaloids were detected. Calli appeared to produce sparse alkaloid profiles in stark contrast to shoot-clumps that had similar profiles to those of the intact plant. Seven shoot-clump strains produced galanthamine predominantly whereas another three were dominated by lycorine. Shoot-clump strains cultivated under light accumulated about two-times more galanthamine (an average of 74 μg/g of dry weight) than those cultivated in darkness (an average of 39 μg/g of dry weight). In compa

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29

Kim, D. S. "Synthesis of Alkaloid (-)-205B." Synfacts 2006, no. 10 (2006): 0977. http://dx.doi.org/10.1055/s-2006-949316.

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30

WILLIAMS, DAVID R. "MARINE ALKALOID TOTAL SYNTHESIS." Chemical & Engineering News 82, no. 25 (2004): 7. http://dx.doi.org/10.1021/cen-v082n025.p007.

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31

Meijerink, Whilhem J. H. J., Patricia E. Molina, and Naji N. Abumrad. "MAMMALIAN OPIATE ALKALOID SYNTHESIS." Shock 12, no. 3 (1999): 165–73. http://dx.doi.org/10.1097/00024382-199909000-00001.

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32

Miyashita, Masaaki. "Recent progress in the synthesis of bioactive polycyclic natural products." Pure and Applied Chemistry 79, no. 4 (2007): 651–65. http://dx.doi.org/10.1351/pac200779040651.

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The zoanthamine alkaloids, a type of heptacyclic marine alkaloid isolated from colonial zoanthids of the genus Zoanthus sp., have distinctive biological and pharmacological properties as well as their unique chemical structures with stereochemical complexity. Namely, norzoanthamine can suppress the loss of bone weight and strength in ovariectomized mice and has been considered a promising candidate for an antiosteoporotic drug, whereas zoanthamine has exhibited potent inhibitory activity toward phorbol myristate-induced inflammation in addition to powerful analgesic effects. Recently, norzoant

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33

Keck, Gary E., Erik N. K. Cressman, and Eric J. Enholm. "Intramolecular allylstannane cyclizations in alkaloid synthesis: applications to pyrrolizidine alkaloids." Journal of Organic Chemistry 54, no. 18 (1989): 4345–49. http://dx.doi.org/10.1021/jo00279a022.

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34

Martin, Stephen F. "Ring-closing metathesis: A facile construct for alkaloid synthesis." Pure and Applied Chemistry 77, no. 7 (2005): 1207–12. http://dx.doi.org/10.1351/pac200577071207.

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Ring-closing metathesis has been found to be a highly effective reaction for the synthesis of functionalized, bridged nitrogen heterocycles. The utility of the process has been established in several case studies, including a facile synthesis of the tropane ring system and efficient, enantioselective syntheses of the natural products (–)-peduncularine and (+)-anatoxin-a.

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35

SHYAMALI, ROY, K. CHATTERJEE SMARAJIT, and P. CHAKRABORTY D. "Synthesis of Heptazolidine." Journal of Indian Chemical Society Vol. 62, Sep 1985 (1985): 673–75. https://doi.org/10.5281/zenodo.6322674.

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Bose Institute, Calcutta-700 009 <em>Manuscript received 17 May 1984, revised 29 July 1985, accepted 11 September 1988</em> Synthesis of heptazolidine, a carbazole alkaloid from <em>Clausena heptaphylla </em>Wt. and Arn. has been reported to confirm the structure of the alkaloid.

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Hájíček, Josef. "A Review on Recent Developments in Syntheses of the post-Secodine Indole Alkaloids. Part II: Modified Alkaloid Types." Collection of Czechoslovak Chemical Communications 72, no. 7 (2007): 821–98. http://dx.doi.org/10.1135/cccc20070821.

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The second part of the planned review on developments in the field of total and formal total synthesis of the post-secodine indole alkaloids concentrates on modified alkaloid types, i.e. those skeletons derived from primary types by formation of additional and/or rupture of existing bonds, while connectivities next to indol(e)ine moiety remain intact. It thus reviews the synthesis of alkaloids of quebrachamine/cleavamine type including VLB-bis-indoles, rhazinilam type, aspidofractinine/kopsane and kopsifoline type, as well as kopsijasminilam alkaloids, lapidilectine B and danuphylline. It cove

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37

Rahman, Md Toufiqur, Veera Venkata Naga Phani Babu Tiruveedhula, Michael Rajesh Stephen, Sundari K. Rallapalli, Kamal P. Pandey та James M. Cook. "Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N4-Methyltalpinine". Molecules 27, № 5 (2022): 1738. http://dx.doi.org/10.3390/molecules27051738.

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The unification of the general synthetic strategy regarding the important and emerging group of C-19 methyl-substituted sarpagine/macroline alkaloids has culminated in the completion of the total synthesis of several bioactive alkaloids. Key transformations include an ACE-Cl mediated late-stage N(4)-demethylation and an anhydrous acid-mediated intramolecular quaternary hemiaminal formation between a tertiary amine and an aldehyde function to allow efficient access to several biologically important alkaloids from this group. Herein, the enantiospecific total synthesis of the first known sarpagi

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38

Yin, Yuling, Riko Katahira, and Hiroshi Ashihara. "Metabolism of Purine Alkaloids and Xanthine in Leaves of Maté (Ilex paraguariensis)." Natural Product Communications 10, no. 5 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000503.

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Accumulation and metabolism of purine alkaloids in leaves of maté ( Ilex paraguariensis) were investigated. In winter, leaves accumulated caffeine but not theobromine, indicating that caffeine is the end product of purine alkaloid synthesis in maté. To elucidate the purine alkaloid metabolism in maté leaves, the metabolic fate of [8-14C]theobromine, [8-14C]theophylline, [8-14C]caffeine and [8-14C] xanthine was investigated in the leaf disks of young and mature leaves. In young maté leaves, significant amounts of theobromine and theophylline were utilized for caffeine biosynthesis, but the conv

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Zhou, Nong, Chun-Mei Mei, Fu-Gui Chen, Yu-Wei Zhao, Ming-Guo Ma, and Wei-Dong Li. "Isolation and Identification of Alkaloid Genes from the Biomass of Fritillaria taipaiensis P.Y. Li." Metabolites 14, no. 11 (2024): 590. http://dx.doi.org/10.3390/metabo14110590.

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Background/Objectives: Fritillaria taipaiensis P.Y. Li is a valuable traditional Chinese medicinal herb that utilizes bulbs as medicine, which contain multiple alkaloids. Biomass, as a sustainable resource, has promising applications in energy, environmental, and biomedical fields. Recently, the biosynthesis and regulatory mechanisms of the main biomass components of biomass have become a prominent research topic. Methods: In this article, we explored the differences in the heterosteroidal alkaloid components of F. taipaiensis biomass using liquid chromatography–mass spectrometry and high-thro

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Peat, Andrew J., and Stephen L. Buchwald. "Novel Syntheses of Tetrahydropyrroloquinolines: Applications to Alkaloid Synthesis." Journal of the American Chemical Society 118, no. 5 (1996): 1028–30. http://dx.doi.org/10.1021/ja953080t.

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Supriyono, A., B. Schwarz, V. Wray, et al. "Bioactive Alkaloids from the Tropical Marine Sponge Axinella carteri." Zeitschrift für Naturforschung C 50, no. 9-10 (1995): 669–74. http://dx.doi.org/10.1515/znc-1995-9-1012.

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Abstract Analysis of the tropical marine sponge Axinella carteri afforded six unusual alkaloids, including the new brominated guanidine derivative 3-bromo-hymenialdisine. The structure elucidation of the new alkaloid is described. The alkaloid patterns of sponges collected in Indonesia or in the Philippines were shown to be qualitatively identical suggesting de novo synthesis by the sponge or by endosymbiontic microorganisms rather than uptake by filterfeeding. All alkaloids were screened for insecticidal activity as well as for cytotoxicity. The guanidine alkaloids hymenialdisine and debromoh

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Putri, Astrid Nindia, Delovita Ginting, Romi Fadli Syaputra, and Fitra Perdana. "Synthesis and characterization of anti-fungal paint production based on bintaro (Cerbera manghas) seed extract as additive." Journal of Aceh Physics Society 12, no. 1 (2023): 1–7. http://dx.doi.org/10.24815/jacps.v12i1.27930.

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Abstrak. Penelitian ini melaporkan sintesis alkaloid dari biji bintaro (Cerbera manghas). Serbuk biji bintaro yang dihasilkan dari sintesis ekstrak biji bintaro (Cerbera manghas) dikarakterisasi menggunakan Spektroskopi Fourier Transform Infrared (FTIR) dan uji fitokimia. Spektrum FTIR hasil pengujian dari sintesis ekstrak biji bintaro menunjukkan puncak kuat pada 3239, 3338, dan 3293 cm-1 dan sudah menunjukkan hasil alkaloid. Hasil pengujian fitokimia juga telah menunjukkan terdapat senyawa alkaloid. Sintesis alkaloid yang telah diperoleh dijadikan zat aditif pada pembuatan cat. Pada peneliti

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Mehta, Goverdhan, M. Sreenivasa Reddy, R. Radhakrishnan, M. V. Manjula, and M. A. Viswamitra. "Alkaloid synthesis: stereoselective approach towards fawcettimine-serratinine group of lycopodium alkaloids." Tetrahedron Letters 32, no. 43 (1991): 6219–22. http://dx.doi.org/10.1016/0040-4039(91)80793-6.

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Bhattacharyya, Dipanjan. "ChemInform Abstract: The Galbulimima Alkaloids - A New Frontier in Alkaloid Synthesis." ChemInform 42, no. 47 (2011): no. http://dx.doi.org/10.1002/chin.201147231.

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Lahare, Rajeshwari Prabha. "Screening of strictocidine synthase and lysine decarboxylase gene involved in alkaloid biosynthesis in plants of Catharanthus rosea, Adathoda vasica and Wedelia trilobata." Research Journal of Biotechnology 17, no. 12 (2022): 74–81. http://dx.doi.org/10.25303/1712rjbt74081.

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Alkaloids are naturally occurring nitrogenous organic compounds of plant and display vast range of pharmacological properties such as anticancer, antiviral, anti-diabetic, antioxidant and antimicrobial activities. Medicinal plants are the main source of secondary metabolites and the enzymatic pathway involved in its production may be enhanced to increase synthesis of metabolites. The strictocidine synthase (STR) and lysine decarboxylase (LDC) gene are involved in biosynthesis of monoterpenoid indole alkaloid and quinolizidine alkaloid respectively. In the present study, STR and LDC gene were a

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Takasu, Kiyosei, Yousuke Yamaoka, Marie Taniguchi, and Ken-ichi Yamada. "Total Synthesis of Phenanthroquinolizidine Alkaloid Cryptopleurine and Phenanthroindolizidine Alkaloid Tylophorine." HETEROCYCLES 97, no. 1 (2018): 292. http://dx.doi.org/10.3987/com-18-s(t)19.

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Shamsiyeva, Nilufar Olim kizi, Mavluda Shernazarovna Ernazarova, Komila Hakimovna Eshonkulova, and Markhabo Balkhiyevna Usmonova. "PROPERTIES OF ALKALOIDS, EFFECTS ON THE BODY, STUDY OF GETTING, QUALITY REACTIONS." EURASIAN JOURNAL OF ACADEMIC RESEARCH 1, no. 2 (2021): 38–41. https://doi.org/10.5281/zenodo.4746864.

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Ma, Xiaochu, Stefan M. Cooper, Fan Yang, Wenhao Hu, and Herman O. Sintim. "Alkaloid Synthesis via Carbenoid Intermediates." Current Organic Chemistry 20, no. 1 (2015): 82–101. http://dx.doi.org/10.2174/1385272819666150810225759.

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Sugita, Teruyo, Junko Koyama, Kiyoshi Tagahara, and Yukio Suzuta. "Synthesis of Terpenoidal Alkaloid, Fabianine." HETEROCYCLES 24, no. 1 (1986): 29. http://dx.doi.org/10.3987/r-1986-01-0029.

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Rao, Nagavaram Narsimha, and Jin Kun Cha. "Concise Synthesis of Alkaloid (−)-205B." Journal of the American Chemical Society 137, no. 6 (2015): 2243–46. http://dx.doi.org/10.1021/jacs.5b00243.

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