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Dissertations / Theses on the topic 'Amide bonds'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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1

Fincham, Christopher I. "Replacement of peptidic amide bonds in drug design." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239080.

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2

Allen, C. Liana. "Catalytic approaches to the synthesis of amide bonds." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549836.

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This thesis outlines work carried out in the last three years concerning the development of novel, atom-economic, catalytic syntheses of amide bonds, determination of the ranges of these reactions through substrate screenings and investigations into the mechanisms by which the reactions are operating. In Chapter 1, an introduction to amide bonds is given, after which a discussion on the synthesis of amide bonds is presented, covering direct coupling methods, enzymatic methods and both non-metal catalysts and metal catalysts used for amide bond synthesis. In the Results and Discussion section,
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3

Ulijn, R. V. "Precipitation driven biocatalysis." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366835.

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4

Hough, Sarita Elizabeth. "Regioselective, Nucleophilic Activation of C-F Bonds in o-Fluoroanilines." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/90657.

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Reactions of fluorinated anilines with stoichiometric Ti(NMe2)4 in mesitylene (typically for 23 h at 120 °C) afforded moderate to high yields of the corresponding N,N-dimethyl-o-phenylenediamine derivatives resulting from defluoroamination of a fluorine atom ortho to the NH2 of the starting aniline. Reactivity increased with additional ring fluorination in general accordance with established regiochemical (activating and deactivating) trends. Based on results, we propose a metal-mediated, SNAr-based mechanism. We report the scope and limitations of this reaction and discuss trends in reacti
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5

pardillo, armando d. "The Influence of the Proximal Amide Hydrogen Bonds and the Proximal Helix Dipole on the Catalytic Activity of Chloroperoxidase." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2270.

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Chloroperoxidase (CPO) is a heme-thiolate protein with exceptional versatility and great potential as a biocatalyst. The CPO reactive species, Compound I ( Cpd I) is of particular interest, as well as the Cytochrome P450 (P450) -type monoxygenase catalytic activity, which has significant biotechnological potential. Proximal hydrogen bonding of the axial sulfur with the backbone amides (NH•••S) is a conserved feature of heme-thiolate enzymes. In CPO, the effect of NH•••S bonds is amplified by the dipole moment of the proximal helix. The role of the proximal region has been disputed as to whethe
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6

Seaman, Lani Anne. "Investigation of the 6d and 5f Orbital Contributions in Actinide Complexes Containing Amide, Ketimide, Aryl, and Alkyl Metal-Ligand Bonds." University of California, Santa Barbara, 2013.

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7

Scheibel, Markus. "Metal-Nitrogen Multiple Bonds with Square-Planar Group 9 Transition Metal PNP Pincer Complexes." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-9944-4.

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8

Nguyen, Khanh Trong. "Proton NMR studies of the interaction of heparin-derived oligosaccharide with biological molecules and the cis/trans isomerization of amide bonds in peptides and peptide/peptoid hybrids." Diss., [Riverside, Calif.] : University of California, Riverside, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3350080.

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Thesis (Ph. D.)--University of California, Riverside, 2009.<br>Includes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed March 10, 2010). Includes bibliographical references. Also issued in print.
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9

Lelievre, Chloé. "Formation de liaisons amides par réactions enzymatiques détournées ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASF026.

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La fonction amide est omniprésente dans les produits naturels et aussi dans de nombreux composés synthétiques comme des principes actifs et des polymères. De nombreuses approches ont été développées pour disposer de méthodes de synthèse efficaces. L'approche la plus courante en chimie conventionnelle est l'acylation d'une amine par un acide carboxylique activé. L'activation nécessite l'utilisation soit d'agents de couplage, résultant en une faible économie d'atomes, soit de catalyseurs couteux parfois utilisés dans des conditions drastiques. Les approches biocatalytiques sont donc des alternat
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10

Rix, Kathryn. "Electrochemical reduction of amides and c=c bonds." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39846.

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Reduction of amides to amines is an important transformation in organic synthesis, which has been identified as among the 'top ten most important reactions' by a consortium of pharmaceutical companies. Presently achieved by hydride or borane reagents, it is both hazardous and generates excessive volumes of effluent and waste. Similarly, chemoselective reduction of C=C bonds, particularly conjugated double bonds, also presents a significant challenge in organic synthesis. Electrochemical synthesis using a flow reactor offers an environmentally benign and energy efficient technology for producin
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11

Cote, Yoann. "Theory and molecular dynamics simulations of the local dynamics and free energy profiles of proteins : application to the interpretation of protein NMR data." Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOS075.

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Comprendre la dynamique locale des protéines dans leur état natif (structure repliée etfonctionnelle) est essentiel pour comprendre leur dynamique globale et leur fonction biologique. Aucours de cette thèse, nous avons étudié la dynamique locale de plusieurs petites protéines enmesurant les fluctuations de sondes locales le long de la séquence d’acide aminé de ces protéines.Nous avons essayé de comprendre la dynamique de ces sondes locales, comment celles-ci serelaxaient entre leurs différentes conformations, comment leurs fluctuations étaient corrélées lesunes aux autres et comment peuvent-el
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12

Skepu, Zoleka G. "Characterization of amide bond hydrolysis in novel hydantoinase-producing bacteria." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1003970.

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This thesis describes a series of investigations into the amide bond-hydrolyzing activity of bacterial strains RU-KM1, RU-KM3L, RU-KM3S, and RU-OR, which were previously isolated for their ability to hydrolyze hydantoins to amino acids. The main aim of the study was to develop biotransformations with potential application in the production of enantiomerically pure amino acids and related compounds. Several compounds may be used as substrates by biocatalysts for the production of amino acids, such as hydantoins, amino nitriles, and amides. These compounds are not only important for amino acid p
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13

Mohy, El Dine Tharwat. "New insights in amide bond formation mediated by boron-based catalysts." Caen, 2016. http://www.theses.fr/2016CAEN2011.

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La formation d'une liaison amide est une réaction fondamentale en chimie organique en raison de l'ubiquité des amides dans la nature. Récemment, sa formation activée par le bore est devenue un domaine en pleine émergence. Par conséquent, un procédé efficace pour la synthèse d'amides par réaction directe entre les acides carboxyliques et les amines a été développé en utilisant l’acide (2- (thiophén-2-ylméthyl) phényl) boronique en tant que catalyseur hautement actif. En utilisant cette méthode, le couplage d’une large gamme de substrats a été réalisé à température ambiante ou légèrement élevée.
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14

McPherson, Christopher. "The development of novel organocatalytic and transition-metal catalysed methodologies for amide bond formation." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30294.

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With the formation of amide bonds being one of the most widely performed reactions within organic chemistry, highly efficient and atom economical approaches enabling the transformation are desired. Traditional methodologies, in which a stoichiometric coupling reagent is utilised, although efficient, have several inherent drawbacks hindering their general applicability, including stoichiometric by-product formation, low atom economy and poor cost effectiveness. Therefore, the development of atom economical catalytic approaches to facilitate the facile synthesis of amide bonds would successfully
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15

Sender, Matthew. "EXAMINATION OF THE N TO PI STAR INTERACTION AND THE PROLINE AMIDE BOND EQUILIBRIUM." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/419093.

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Chemistry<br>Ph.D.<br>The focal point of this thesis is the tertiary amide bond that is unique to proline and hydroxyproline among the proteogenic amino acids. The tertiary amide bond has many consequences biologically. Chief among them is the greatly increased population of the cis amide bond compared to the other amino acids. Ronald Raines of the University of Wisconsin has developed a theory whereby the amide bond equilibrium is derived from the pyrrolidine ring pucker and substituents, through their effect on the n → π* interaction. Three studies were devised to probe Raines’ hypothesis. O
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16

Altieri, Andrea. "Hydrogen bond directed synthesis of novel benzylic amide[2]rotaxane : design and realization of rotational and translational hydrogen bond molecular machines." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11969.

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The aim of my PhD is to study rotaxanes. This study is intended to contribute to the understanding of rotaxanes and to provide some insights into the possibilities of their application, and is divided in two parts accordingly. In the first part of my thesis I develop and analyze new hydrogen-bond templates that contain phosphorus and can be used to improve the existing rotaxane formation processes and to synthesize new rotaxanes. The second part of my research is based on the fact that the form of rotaxanes restricts the macrocycle movements to two options only: rotational and translational mo
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17

Syrstad, Erik Alan. "Neutralization-reionization mass spectrometry and computational studies of hydrogen atom adducts to the amide bond /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/11612.

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18

Inoue, Makoto. "Synthesis and Characterization of Mechanism-Based Inhibitors of γ-Glutamyl Amide Bond Forming/Cleaving Enzymes". Kyoto University, 2000. http://hdl.handle.net/2433/151625.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第8630号<br>農博第1157号<br>新制||農||814(附属図書館)<br>学位論文||H12||N3475(農学部図書室)<br>UT51-2000-R36<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 坂田 完三, 教授 江崎 信芳, 教授 熊谷 英彦<br>学位規則第4条第1項該当
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19

Duddy, William John. "The geometry of hydrogen bonds and carbonyl-carbonyl interactions between trans-amides in proteins and small molecules." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414343.

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20

Meng, Hai Yun. "Determinants of cis-trans isomerism of the aromatic-prolyl amide bond and design of lathanide-binding peptides." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 2.04 Mb., 133 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1432291.

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21

Emerling, Michael Roy Richards John Richards John. "Enzymatic hydrolysis of the amide bond : mutagenic studies of the mechanisms of [alpha]-lytic protease and [beta]-lactamase /." Diss., Pasadena, Calif. : California Institute of Technology, 1991. http://resolver.caltech.edu/CaltechETD:etd-06202007-140449.

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22

Yip, Wing-ping, and 葉永平. "Alkane C-H bond oxidations and alkene dihydroxylations by oxorutheniumcomplexes of chelating tertiary amine ligands." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246254.

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23

Haffemayer, Benjamin. "Development of novel amine-directed Pd(II)-catalysed sp2 and sp3 C-H bond functionalisation processes." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607792.

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24

Ben, Halima Taoufik. "Engaging Esters as Cross-Coupling Electrophiles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39493.

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Cross-coupling reactions, where a transition metal catalyst facilitates the formation of a new carbon-carbon or carbon-heteroatom bond between two coupling partners, has become one of the most widely used, reliable, and robust family of transformations for the construction of molecules. The Nobel Prize was awarded to pioneers in this field who primarily used aryl iodides, bromides, and triflates as electrophilic coupling partners. The expansion of the reaction scope to non-traditional electrophiles is an ongoing challenge to enable an even greater number of useful products to be made from simp
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25

Ibrahim, Sherif M. S. "Quinazolin-2-yl-guanidines for treatment of neuropsychiatric disorders and the oxidative preparation of N,O-acetals linked to the amide bond of peptides." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6437.

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This thesis consists of two parts, both on synthetic chemistry with medicinal and biological relevance. Part one aims to develop methods for the preparation of quinazoline derivatives. A streamlined method for the preparation of 6-substituted-4-methyl-2-quinazolyl-guanidines and their respective amides has been presented here, using inexpensive and readily available starting materials such as para-bromoaniline, dicyandiamide (DCDA), and other reagents that are well-established for reactions such as Heck coupling, Suzuki coupling, and Ullman coupling reactions. In part two a novel methodology w
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26

Xiong, Heng-Ying. "New methodologies for the introduction of the SCF3 and Cl groups by C(sp3)-H bond functionalization and the design of original fluorinated electrophilic reagents." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMIR04.

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Le domaine de recherche de la chimie du fluor a connu un essor considérable. En particulier, le motif SCF3 et plus récemment les groupements SCF2R (R = H, SO2Ph, SAr, COAr, Rf) ont fait l'objet d'une attention particulière de la part de la communauté scientifique du fait de leurs propriétés remarquables. Dans ce contexte, le développement de nouvelles méthodologies et de réactifs originaux pour l'introduction de ces groupements fluorés a suscité un fort intérêt. En conséquence, les objectifs de cette thèse ont été 1) de développer de nouvelles méthodologies pour la fonctionnalisation de liaiso
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27

Reich, Blair Jesse Ellyn. "Cyanide-catalyzed C-C bond formation: synthesis of novel compounds, materials and ligands for homogeneous catalysis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4987.

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Cyanide-catalyzed aldimine coupling was employed to synthesize compounds with 1,2-ene-diamine and α-imine-amine structural motifs: 1,2,N,N'- tetraphenyletheylene-1,2-diamine (13) and (+/-)-2,3-di-(2-hydroxyphenyl)-1,2- dihydroquinoxaline (17), respectively. Single crystal X-ray diffraction provided solidstate structures and density functional theory calculations were used to probe isomeric preferences within this and the related hydroxy-ketone/ene-diol system. The enediamine and imine-amine core structures were calculated to be essentially identical in energy. However, additional effects-su
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28

Pardue, Daniel B. "Computational Studies of C–H/C–C Manipulation Utilizing Transition Metal Complexes." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801892/.

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Density Functional Theory (DFT) is an effective tool for studying diverse metal systems. Presented herein are studies of a variety of metal systems, which can be applied to accomplish transformations that are currently difficult/impossible to achieve. The specific topics studied utilizing DFT include: 1) C–H bond activation via an Earth-abundant transition metal complex, 2) C–H bond deprotonation via an alkali metal superbase, 3) and amination/aziridination reactions utilizing a CuI reagent. Using DFT, the transformation to methanol (CH3OH) from methane (CH4) was examined. The transition metal
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29

RACAPE, EVELYNE. "Influence des fonctions amides sur les proprietes physicochimiques des pectines." Nantes, 1989. http://www.theses.fr/1989NANT2001.

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Gelification des pectines amidees en presence de calcium. Etude de modeles simplifies (acides pectiques amides). Les pko dependent du parametre de densite de charge et non pas du taux d'amidation/repartition non aleatoire des fonctions amides. La sensibilite au calcium des pectines amidees resulte de l'alternance de blocs de fonctions acides libres et methyles reparties aleatoirement et de fonctions amides, generateurs de liaisons h intermoleculaires, provenant de leur synthese concentre en ammoniac et en pectine
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30

Gurgel, Alexandre Leal. "Estudos sobre a síntese de novos inibidores da InhA (enoil-acp reductase da Mycobacterium tuberculosis." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/46/46137/tde-12042018-084312/.

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Ao contrário da percepção da sociedade em geral, a tuberculose ainda é uma das mais graves doenças infecciosas da atualidade, estando à frente da HIV/AIDS como uma das maiores causas de morte por infecção. Apesar de todos os avanços recentes, o aparecimento de cepas multirresistentes não permitiu sua erradicação. Em 2016, a OMS lançou novos alvos rumo à erradicação global da enfermidade (End TB), alvos estes que, no Brasil, foram divulgados no Plano Nacional pelo Fim da TB, do Ministério da Saúde. Para que estas metas possam ser atingidas, a pesquisa em busca de novos fármacos, que possam dimi
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31

Kramer, Ricardo Klaus. "Estudo da interação da água com a celulose e o amido por meio da técnica de termogravimetria." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/18/18158/tde-16032015-154829/.

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A interação da água com a celulose e com o amido é de grande importância para a compreensão das propriedades de ambos polissacarídeos e fundamental para o desenvolvimento de novas aplicações tecnológicas. Entre as novas aplicações estão em destaque a nanocelulose, como os nanocristais e microfibrilas. A preparação desses materiais é fortemente influenciada pela interação das ligações de hidrogênio presente nas fibras de celulose, tanto de caráter intra como intermolecular. Essas interações são responsáveis pelas propriedades mecânicas desses materiais uma vez que as moléculas estão ligadas uma
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32

Mora, Anne-Sophie. "Élaboration de revêtements époxy pour contact alimentaire à empreinte environnementale réduite A perspective approach on the amine reactivity and the hydrogen bonds effect on epoxy-amine systems vanillin-derived amines for bio-based thermosets synthesis of biobased reactive hydroxyl amines by amination reaction of cardanol-based epoxy monomers synthesis of pluri-functional amine hardeners from bio-based aromatic aldehydes for epoxy amine thermosets cardanol-based epoxy monomers for high thermal properties thermosets." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2019. http://www.theses.fr/2019ENCM0012.

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Les travaux de thèse présentés sont issus d’une collaboration industrielle avec la société Nouvelle Sogatra, spécialisée dans la conception, la fabrication et la commercialisation de revêtements de protection bi-composants répondant aux normes d’alimentarité. L’objectif principal de ce projet est de proposer de nouveaux revêtements époxydiques performants en utilisant des produits biosourcés et, dans l’idéal, moins dangereux pour l’Homme et pour l’environnement. Ces travaux de thèse s’axent autour de l’identification de nouvelles méthodologies de synthèse de durcisseurs aminés biosourcés qui s
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33

Andersson, Ida E. "Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42082.

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Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). Interestingly, vaccination with the Aq/CII259-273 complex can relieve symptoms and cause disease regression in mice. This thesis describes the use of modified glycope
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Tan, Yi Lei. "Structural and Biophysical Characterisation of Denatured States and Reversible Unfolding of Sensory Rhodopsin II." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289718.

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Our understanding of the folding of membrane proteins lags behind that of soluble proteins due to the challenges posed by the exposure of hydrophobic regions during in vitro chemical denaturation and refolding experiments. While different folding models are accepted for soluble proteins, only the two-stage model and the long-range interactions model have been proposed so far for helical membrane proteins. To address our knowledge gap on how different membrane proteins traverse their folding landscapes, Chapter 2 investigates the structural features of SDS-denatured states and the kinetics for
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35

Rguini, Noureddine. "Modélisation informatique de propriétés moléculaires." Nancy 1, 1988. http://www.theses.fr/1988NAN10209.

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Étude des possibilités offertes par les méthodes semi-empiriques de la chimie quantique, en matière de modélisation moléculaire. Étude du caractère acidobasique d'une molécule (amine, alcool). Étude du phénomène de liaison hydrogène. Modélisation de la surface des alumines amorphes
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36

Schmidtz, Ryan Patrick. "Solid phase amide synthesis using Staudinger-Vilarrasa coupling and microwave irradiation /." 2009. http://digitalcommons.butler.edu/ugtheses/47/.

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37

Milam, Sarah Joan. "Spontaneous amide bond formation of amino acids in aqueous solution /." 2009. http://hdl.handle.net/10288/1207.

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38

Hsiao, Chia-Jung, and 蕭嘉榮. "Probing C–H…X hydrogen bonds in amide-functionalized imidazolium salts under high pressure." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/61437700750011292640.

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碩士<br>國立東華大學<br>化學系<br>93<br>We have probed under high pressure the C–H hydrogen bonds formed by N,N’-disubstituted imidazolium ions having PF6-and Br- counterions. High-pressure infrared spectral profiles, x-ray crystallographic analysis, and ab initio calculations allow us to make a vibrational assignment of these compounds. The appearance of a signal for the free-NH unit (or weakly bonded N–H…F unit) in the infrared spectrum of the PF6- salt indicates that conventional N–H…O and N–H…N hydrogen bonds do not fully dominate the packing. It is likely that the charge-enhanced C2–H…F interactions
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39

Chang, Wen-Hsin, and 張文馨. "Synthesis and Characterization of Low Molecular Weight Azobenzene Materials Containing Amide Bonds for Holographic Materials." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/c6d64u.

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碩士<br>國立中山大學<br>材料與光電科學學系研究所<br>106<br>In this study, we prepared several azobenzene composites for optical storage. The light-induced interconversion allows azobenzene composites to be used as rewritable and erasable optical storage materials. 4-Aminoazobenzene (AAB) was selected as the pho-tochromic monomer, and two kinds of substrates with different low molecular weights were used to form composites by means of covalent bonds. The substrates used were (1,3,5-Benzenetricarbonyl trichloride, BTC), (Benzoyl chloride, BC). The synthesis of materials AT and AAB/BC was determined by nuclear magne
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40

Reddy, N. Damodara. "Design And Access To Disallowed And Unusual Conformers Of Peptides In Crystals And In Solution : Structural Consequences Of The Imidate And Thioimidate Isosteres For The Peptide Bond." Thesis, 2012. http://hdl.handle.net/2005/2511.

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This thesis entitled “Design and Access to Disallowed and Unusual Conformers of Peptides in Crystals and in Solution: Structural Consequences of the Imidate and Thioimidate Isosteres for the Peptide bond” is divided into eight chapters. Imidate Modification The range of disallowed dihedral angles for residues in peptides is governed by their local steric and electrostatic clashes. Rare tolerances of violations in these angles are attributed to distortions in both local and global bond characteristics of the peptides. Discerning the origins of such disallowed angles and the consequent disto
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41

Pan, Si-Der, and 潘賜德. "Synthesis of ceramide analog as a core amine for constructing library via amide bond formation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/40093971145722594477.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>95<br>Recent studies have shown that the lipid antigens by the immune system is important for antiviral and antitumer. The aim of this study is synthesis of amino-ceramide as a core compound that coupling with various acids for constructing library of screenning experiment via amide bond formation. As the starting material is serin. Amino group of serin was first protected with Boc2O, followed by methylation and acetonidation to forming N,O-isopropylidine. Then reduced ester group into hydroxyl group. The main skeleton structure was constructed by Swern oxidation
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Hernández, J. G., K. J. Ardila-Fierro, Deborah E. Crawford, S. L. James, and C. Bolm. "Mechanoenzymatic peptide and amide bond formation." 2017. http://hdl.handle.net/10454/17698.

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No<br>Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of α,α- and α,β-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.<br>We thank RWTH Aachen University for support from the Distinguished Professorship Program funded by the Excellence Initiative of the
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43

Harbeson, Scott L. "Inhibition of aminopeptidases by peptides incorporating amide bond replacements." 1986. http://catalog.hathitrust.org/api/volumes/oclc/14171031.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1986.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 250-262).
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Wen, Ya-Ping, and 温雅評. "Development and Evaluation of Recyclable Catalystsfor Amide Bond Formation." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/cpg68z.

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碩士<br>國立臺灣大學<br>化學研究所<br>105<br>Amide bond formation has been one of the most important reactions in organic synthesis. From natural biomolecules to synthetic products, the importance and utility of amide bonds have received tremendous attention for centuries. However, current synthetic strategies for amide bond formations still suffer from several drawbacks including the use of stoichiometric amounts of expensive coupling reagents as well as massive production of byproducts and wastes. Thus, there is a need for development of mild, simple and waste-free synthetic methods for amide bond format
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Ashley, Melissa Ann. "Photoredox-Catalyzed Site-Selective Functionalization of Primary Amine Derivatives." Thesis, 2021. https://doi.org/10.7916/d8-nz4d-fj65.

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Given the prevalence of primary amines in biologically active molecules, an important area of research is devoted to creating methods to site-selectively functionalize their C(sp³)-H bonds. For simple aliphatic primary amines, many of these C-H bonds are chemically indistinguishable due to their similar electronics and sometimes, steric environments. Through strategic choice of activating group, site-selective functionalization at both α- and ẟ- positions is achieved. Exploiting inductive effect allows for a photoredox-catalyzed α-C(sp³)-H alkylation of trifluoromethanesulfonamides. In the cas
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Gong, Wei. "Synthesis of internal amide bond short interfering RNAs (siRNAs) and investigation of their gene silencing properties." Thesis, 2013. http://hdl.handle.net/10155/300.

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Cancer is a leading cause of death worldwide, accounting for around 13% of all death [1]. Traditional cancer therapeutics usually require careful selection of one or more intervention, such as surgery, radiotherapy, and chemotherapy, which have made momentous progress, but have ample limitations [2]. The next generation of cancer therapeutics will specifically target processes responsible for the growth and survival of cancer cells. Among the most promising of these molecularly-targeted therapeutics are short interfering RNAs (siRNAs). These siRNAs serve as the effectors of RNA interference, a
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Martins, João Pedro Robalo. "European inflation-linked bonds: an historical overview and the benefits amid portfolio management." Master's thesis, 2015. http://hdl.handle.net/10071/11420.

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Classificação JEL: G11, G15<br>A presente dissertação propõe-se a introduzir de um ponto de vista geral a historia das Inflation-Linked Bonds (ILBs), coloquialmente conhecidas como linkers, dos países Europeus desenvolvidos e com especial enfoque em Franca, Alemanha e Italia sendo que estes são os principais emitentes de linkers excluindo o Reino Unido. Para alem da historia, a mecânica destes instrumentos assim como alguns dos conceitos base relacionados, tal como breakeven inflation rates, serão apresentados de forma a explicar como funcionam as ILBs e providenciam proteção contra a inflação
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Lee, Ming-Hsun, та 李明訓. "Synthesis of 4'-α/β-aminomethyl dihydrouridine analogs construction of libraries via amide-bond formation". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/18482427631937005984.

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Taleb, Sereshki Farzaneh. "Rh-catalyzed asymmetric C-H bond activation by chiral primary amine." 2017. http://hdl.handle.net/1993/32091.

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Developing asymmetric C-H bond activation methods in order to achieve enantiopure products is crucial for the advancement of the field and for the production of novel chiral compounds. Therefore, we tried to develop this area of organic chemistry by presenting metal catalyzed stereoselective C-H bond activation utilizing chelation-assisted tools. The first section of this study involves Rh(I) catalyzed asymmetric C-H bond activation of a series of ketones via an intermolecular procedure. By this method, we examine ortho-alkylation of aromatic ketones and β-functionalization of α-β unsaturated
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Schönafinger, Georg [Verfasser]. "Amide bond formation in nonribosomal peptide synthesis : the formylation and condensation domains / vorgelegt von Georg Schönafinger." 2007. http://d-nb.info/987570285/34.

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