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Dissertations / Theses on the topic 'Amino acid'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Leung, Wai-yin David. "Synthesis and physical properties of fatty acid derivatives containing amino, amido functions and L-amino acid residues /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13637666.

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2

Beckett, Philip Ronald. "Amino acid oxidation." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253828.

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The aim of the study was to determine the efficiency with which the carbon skeletons of essential amino acids are utilised by the pig when they are limiting in its diet. This requires the oxidation rate of an amino acid to be measured accurately using a tracer labelled with an isotope of carbon or hydrogen. The use of carbon labelled tracers requires the animal to be enclosed in a sealed chamber for the collection of CO<sub>2</sub>; to avoid this the use of [<sup>3</sup>H]-labelled tracers was investigated. The oxidation rates of [<sup>14</sup>C]-labelled tracers when the tracee was limiting a

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3

Ebikeme, Charles E. "Amino acid transporters and amino acid metabolism in trypanosoma brucei brucei." Connect to e-thesis, 2007. http://theses.gla.ac.uk/55/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.

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4

Ebikeme, Charles E. "Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/55/.

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The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An effective means of selective drug delivery is to use plasma membrane transport systems to mediate the entry of drugs into the cell. Some amino acid transporters fulfil the criteria needed for successful exploitation of nutrient transport systems for drug delivery. The Trypanosoma brucei genomic database

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5

Thomson, James E. "Î²-amino acid organocatalysis." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442988.

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6

Peters, Steven Carlton. "Crosslinked amino acid derivatives." Title page, table of contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09php4831.pdf.

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7

Moncrieff, Hazel Marie. "Amino acid and peptide modification using enantiopure amino glyoxals." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361275.

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8

Van, Kralingen Leon. "Controlled polymerization of amino acid derivatives." Thesis, Link to the Internet, 2008. https://etd.sun.ac.za/jspui/handle/10019/919.

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9

Razzino, Pasquale. "Asymmetric [alpha]-amino acid synthesis /." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phr279.pdf.

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10

Roger-Evans, Tania. "Asymmetric #alpha#-amino acid synthesis." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279903.

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11

Coates, Ian A. "Functional amino acid-based gelators." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489189.

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Several libraries of gelators have been reported. We have described the use of Boc-protected i amino acids such as tryptophan, cysteine, alanine, phenylalanine, proline and glutamine for the gelation of organic solvents. Side chain fiinctionality imparted individual gelation properties on these compounds. The gelation solvent, minimum gelation concentration (MGC) and thermal stabilities were measured and related back to the previously published lysine-based gelator Lys. The cysteine-based gelator Cys was used to form gels where gold nanoparticles have been aligned along gel nanofibres

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12

Harris, Lawrence Daniel. "Conformationally constrained amino acid analogues." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526527.

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13

Langer, Stefan. "Amino acid interactions in pigs." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336591.

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This thesis examines the influence of moderate excesses of protein, amino acid mixtures or single amino acids on the utilisation of dietary protein and amino acids by growing pigs. The work focused mainly on amino acid interactions affecting the utilisation of lysine, threonine and methionine, amino acids frequently limiting in pig diets. In the first part of the thesis the influence of dietary excesses of single amino acids (methionine, phenylalanine, tyrosine, tryptophan, histidine and lysine) were investigated. The results showed that an excess of about twice the requirement of one of these

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14

Parr, Nigel. "Asymmetric #alpha#-amino acid synthesis." Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302251.

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15

Bar-Peled, Liron. "Amino acid regulation of mTORC1." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83764.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.<br>Cataloged from PDF version of thesis. "September 2013."<br>Includes bibliographical references.<br>Mammalian target of rapamycin complex I (mTORC1) is an atypical Ser/Thr kinase that regulates cellular and organismal growth. Accordingly, mTORC1 has substantial roles in regulating insulin sensitivity and lifespan, and when deregulated, it is implicated in the pathogenesis of common cancers. mTORC1 responds to a diverse set of stimuli, including growth factors, oxygen availability, energy and amino acid levels in

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16

Vieira, Pedro Emanuel Ferreira dos Reis. "Amino acid toxicity in Zebrafish." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/8229.

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Mestrado em Biologia Aplicada - Biologia Molecular e Celular<br>Proteins are synthetized through the mechanism of translation and are constituted by amino acids. Besides being the basic units of proteins, amino acids also play other important roles in the cell such as signaling or regulation of cell growth. However, in excess, amino acids can be toxic, although the mechanism of toxicity is still not clear. In this study we used zebrafish as a vertebrate model to assess the toxicity induced by different amino acids as a result of nutritional imbalance. Moreover, we evaluated the changes i

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17

Poole, Philip. "Amino acid metabolism in Rhizobium." Thesis, Poole, Philip (1986) Amino acid metabolism in Rhizobium. PhD thesis, Murdoch University, 1986. https://researchrepository.murdoch.edu.au/id/eprint/51728/.

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Addition of a broad range of L-amino acids and several D-amino acids to washed cells of Rhizobium leguminosarum strains WU235 and MNF3841 grown on glucose/NH4Cl elicited a low rate of O2 consumption. L-Glutamate, L-glutamine, L-aspartate, L-asparagine, L-alanine or L-histidine served as the sole source of nitrogen and carbon for growth of strain WU235 and each caused a several-fold increase in the amino acid dependent O2 consumption. In all these cultures excess ammonia was liberated, with the quantity depending on the number of nitrogen atoms per amino acid molecule. A very high dicarboxylic

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18

Wei, Hen-Wei. "Effect of long-term amino-acid deficiency on the amino-acid composition of the body." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302436.

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The aim of this study was to assess changes in the amino-acid composition of the body and in the fractional protein synthesis rates of individual organs or of haemoglobin as a result of long-term amino-acid deficiency in both growing and adult animals. The body weight loss of adults and the growth rates of growing animals were controlled by adjusting the degree of amino-acid deficiency according to individual body weight changes. Adult rats given amino acid-deficient diets had lower absolute weights of muscle (p = 0.052), liver (p = 0.002) and gastrointestinal tract (p < 0.001) than adequately

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19

梁偉賢 and Wai-yin David Leung. "Synthesis and physical properties of fatty acid derivatives containingamino, amido functions and L-amino acid residues." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31233752.

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20

Wilson, Yvonne Martha. "Directed evolution of D-amino acid oxidase for the oxidation of non-proteinogenic amino acids." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/11590.

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Random mutagenesis libraries were prepared by propagating the <i>Trigonopsis variabilis</i> D-amino acid oxidase (TvDAAO) gene in a mutator strain and by performing error-prone PCR (epPCR) on the <i>Rhodotorula gracilis </i>D-amino acid oxidase (RgDAAO) gene. These libraries were initially screened using a solid-phase for detection of activity towards β-amino acids. To overcome reproducibility problems, a high-throughput liquid-phase screening method in 96-well plate format was developed, evaluated and used to screen the RgDAAO epPCR library. In the absence of any detectable activity towards t

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21

Palii, Stela S. "Transcriptional regulation of the human system a amino acid transporter, snat2 gene by amino acid availability." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008371.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 210 pages. Includes Vita. Includes bibliographical references.

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22

Sasaki, Shigeru. "Normal mode assignments of infrared spectra of amino acid crystals and a calcium amino acid crystal." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325626.

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23

Jones, Helen N. "Placental amino acid transfer : regulation of amino acid transport system A in the BeWo cell line." Thesis, University of Aberdeen, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424944.

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In this thesis regulation of amino acid transport system A in the placenta is investigated. Firstly, a suitable in vitro placental model is identified from two clones of the BeWo choriocarcinoma cell line. Both the ATCC and b30 clones show the phenotypic and genotypic characteristics of the parent cell line. The b30 clone forms a polarised monolayer when cultured on permeable filters suitable for studying transcellular transport. The b30 clone was chosen as the model to be used for all further studies in this thesis. The regulation of amino acid transport system A by substrate restriction w

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24

Larue, Ross C. "A novel aminoacyl-tRNA synthetase and its amino acid, pyrrolysine, the 22nd genetically encoded amino acid." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1261432150.

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25

Tan, Eng Wui. "Regioselective modification of amino acid derivatives /." Title page, contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09pht1612.pdf.

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26

Cooper, Leah. "Nonessential amino acid metabolism in humans." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52641.

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Nutritionally, there is a dietary requirement for the essential amino acids (EAA) but also a requirement for nitrogen (N) intake for the de novo synthesis of the nonessential amino acids (NEAA). It has been suggested that some NEAA may be more metabolically important than others. The first study (Glutamate Requirement Study) aims to examine the application of the indicator amino acid oxidation (IAAO) technique to determine if a dietary requirement for glutamate exists in adult humans. The second study (NEAA Study) aims to determine the metabolic demand of nine of the NEAA (Ala, Arg, Asn, Asp,

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27

Brzezinska, Selldén Eva. "Amino acid-induced thermogenesis during anaesthesia /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3212-3/.

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28

Harvey, Catherine Mary. "Amino acid transport in red cells." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236116.

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29

Foulds, A. "The amino acid requirements of cattle." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.482883.

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30

Smart, Tristan Jamie. "Investigation of L-amino acid hydroxylases." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:1b94c030-8364-4617-bae3-7a59fe13f901.

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Ferrous-iron/2-oxoglutarate(2-OG)-dependent oxygenases have emerged as a widely distributed family of oxygenases. They have applications both in biocatalysis and as pharmaceutical/agrochemical targets. One of the first subfamilies of 2-OG oxygenases to be studied in detail were the prolyl hydroxylases. The work described in my thesis focused on substrate analogue studies on the proline hydroxylases and on a highly unusual type of 2-OG oxygenase that catalyses the production of ethylene from 2-OG. The work involved the development of assays, in particular mass spectrometry and nuclear magnetic

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31

Weiser, Armin. "Amino acid substitutions in protein binding." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15962.

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Die Modifizierung von Proteinsequenzen unter anderem durch den Austausch von Aminosäuren ist ein zentraler Aspekt in evolutionären Prozessen. Solche Prozesse ereignen sich nicht nur innerhalb großer Zeiträume und resultieren in der Vielfalt des Lebens, das uns umgibt, sondern sind auch täglich beobachtbar. Diese mikroevolutionären Prozesse bilden eine Grundlage zur Immunabwehr höherer Wirbeltiere und werden durch das humorale Immunsystem organisiert. Im Zuge einer Immunantwort werden Antikörper wiederholt der Diversifizierung durch somatische Hypermutation unterworfen. Ziele dieser Arbeit ware

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32

Kociuba, Katherine. "Radical functionalisation of amino acid derivatives /." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phk76.pdf.

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33

Svennerstam, Henrik. "Amino acid uptake in Arabidopsis : the transporters involved, kinetics of uptake and growth on amino acids /." Umeå : Dept. of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200850.pdf.

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34

Agarwal, Shailesh Ramjilal. "Pharmacological modeling and regulation of excitatory amino acid transporters (EAATS)." CONNECT TO THIS TITLE ONLINE, 2007. http://etd.lib.umt.edu/theses/available/etd-09262007-111510/.

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35

Erasmus, Morné. "Amino acid requirements of feedlot cattle according to the duodenal and whole empty body essential amino acid profile." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52085.

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Thesis (MScAgric)--University of Stellenbosch, 2001.<br>ENGLISH ABSTRACT: The purpose of this study was to determine the essential amino acid requirements of beef cattle under feedlot conditions through evaluation of the duodenal and whole empty body essential amino acid compositions. To define the ideal protein required for growth, the whole empty body essential amino acid compositions of 8 beef steers (Simmental and Hereford crosses) was investigated. The amino acid composition of the components (carcass, metabolic organs and residual fraction), was pooled relative to their respective

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36

Yettella, V. Ramesh Reddy. "Riboflavin Photosensitized Oxidation of Amino Acids." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1217897521.

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37

Mularoni, Loris. "Comparative genomics of amino acid tandem repeats." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7187.

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Tandem amino acid repeats, also known as homopolimeric tract or homopeptides, are very common features of eukaryotic genomes and are present in nearly one-fifth of human encoded proteins. These structures have attracted much interest in the early 1990s when a number of neurological diseases associated with repeat expansion mutations were discovered in humans. Despite their abundance in coding proteins, little is known about their functional consequences. Two scenarios have been proposed. In one, tandem amino acid repeat is considered a neutral structure generated by slippage event and eventual

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38

López, Ferrando Víctor. "Functional characterization of single amino acid variants." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668545.

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Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common kind of variation affecting coding DNA, without generally presenting any damaging effect. With the advent of next generation sequencing technologies, the detection of these variants in patients and the general population is easier than ever, but the characterization of the functional effects of each variant remains an open challenge. It is our objective in this work to tackle this problem by deve

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39

Patson, P. A. "Regulation of branched-chain amino acid oxidation." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355766.

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40

Banerji, Suneale. "Aromatic amino acid biosynthesis in Pneumocystis carinii." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336091.

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41

Barker, Gareth Allan. "Neutral amino acid transport in bovine chondrocytes." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257824.

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42

Simon, Michelle. "Characterisation and evolution of amino acid repeats." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541962.

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43

Goubet, D. C. M. "Asymmetric synthesis of α-amino acid derivatives". Thesis, Swansea University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637081.

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A general background to α-amino acids is discussed in the first chapter. After a brief account on classification, properties and applications of these compounds, asymmetric processes leading to optically enriched residues are reviewed in detail. The second chapter describes the envisaged stereoselective approach towards these substrates involving Michael-type addition onto a chiral didehydroalanine derivative. Syntheses of α,β-unsaturated amino acids are reviewed after a brief section on Michael-type reactions. The preparation of a chiral didehydroamino acid residue has been investigated using

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44

Hay, M. P. "Atom transfer reactions of amino acid derivatives." Thesis, University of Canterbury. Chemistry, 1987. http://hdl.handle.net/10092/7974.

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Investigations of atom transfer reactions of amino acid derivatives are described in this thesis. Reaction of N-benzoylvaline methyl ester (29a) with sulphuryl chloride gave the β-chlorovaline derivative (30a) and lesser amounts of diastereoisomers of the r-chlorovaline derivative (31a). Studies of reactions of the valine derivatives (29a-c) with sulphuryl chloride, and of the photolyses of the corresponding N-chlorovaline derivatives (39a-c) have shown that the reaction of (29a) with sulphuryl chloride and the photolysis of (39a) involve regioselective intermolecular transfer of the respectiv

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45

Marie-Pierre, Hasne. "Amino acid transporters in Trypanosoma brucei brucei." Thesis, University of Glasgow, 2001. http://theses.gla.ac.uk/6544/.

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Two approaches have been used to investigate the nature of amino acid transport in T. brucei. The first approach involved studying the uptake of radiolabelled amino acids by the parasite, the second approach involved the identification, cloning and expression in a heterologous system of a gene encoding for a putative amino acid transporter. The biochemical approach revealed that methionine uptake was of relatively high affinity in procyclic and bloodstream forms and dependent on a proton motive force. The recognition motif of this transporter encompasses the amino acid core as well as the two

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46

Langran-Goldsmith, A. E. "Alpha, alpha-dialkylglycines as amino-acid analogues." Thesis, University of Exeter, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353998.

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47

Baresic, A. "Structural analysis of single amino acid polymorphisms." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344177/.

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Understanding genetic variation is the basis for prevention and diagnosis of inherited disease. In the `next generation sequencing' era with rapidly accumulating variation data, the focus has shifted from population-level analyses to individuals. This thesis is centred on the problem of gathering, storing and analysing mutation data to understand and predict the effects single amino acid mutations will have on protein structure and function. I present analysis of a subset of mutations and a new predictive method implemented to expand the coverage of the structural effects by our pipeline. I ch

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48

Wang, Alice Chun-Yin. "Amino acid metabolism in the inflammatory niche." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/28572.

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Stroma and parenchyma represent the supportive and functional components in every organ of the body, respectively. Beyond their ability to produce structural support and to differentiate into tissues of mesodermal origin, mesenchymal stromal cells (MSC) exhibit potent immunomodulatory properties. Such a function requires an activation step ('licensing signal') provided by the inflammatory microenvironment to which MSC are exposed. My results have attributed immunosuppressive effects of MSC to essential amino acid (EAA) deprivation. Amongst the EAA consuming enzymes examined, blocking nitric ox

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49

Gaston, Marsha. "Biosynthesis of pyrrolysine, the 22nd amino acid." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1318533705.

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50

Seyedhosseini, Ensieh. "Piezoelectricity and ferroelectricity in amino acid glycine." Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15169.

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Doutoramento em Nanociências e Nanotecnologia<br>Bioorganic ferroelectrics and piezoelectrics are becoming increasingly important in view of their intrinsic compatibility with biological environment and biofunctionality combined with strong piezoelectric effect and switchable polarization at room temperature. Here we study piezoelectricity and ferroelectricity in the smallest amino acid glycine, representing a broad class of non-centrosymmetric amino acids. Glycine is one of the basic and important elements in biology, as it serves as a building block for proteins. Three polymorphic forms wit

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