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Journal articles on the topic 'Amino Compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Journal, Baghdad Science. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME (2-AMINO-5-THIOL-1, 3, 4-THIADIAZOLE DERIVATIVES." Baghdad Science Journal 4, no. 1 (2007): 89–94. http://dx.doi.org/10.21123/bsj.4.1.89-94.

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Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4-thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4-thiadiazole, compound E: 2- amino-5-(2-Propanylthio)-1,3,4-thiadiazol) and compound F:2(o-chlorobenzylamino)-5-(2-propanyl thio)-1,3,4 thiadiazol. All prepared compounds were diagnosed by (IR) and (UV) Spectroscopy. All of those compounds were screened for their anti-microbial activity in vitro. The results show that most of the compounds A, B, C exhibit

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2

Zaki Dawood, Nagham M., Zainab Faiyq Saeed, and Banan Borhan Saeed. "SYNTHESIS OF ACETYLENIC AMINO DERIVATIVES OF 2-(2-((2,6- DICHLOROPHENYL)AMINO)PHENYL)ACETIC ACID." Chemical Problems 22, no. 3 (2024): 369–81. http://dx.doi.org/10.32737/2221-8688-2024-3-369-381.

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After reviewing a number of researches that demonstrate the effectiveness of a number of compounds containing the acetylenic amine group as antimicrobials and antiproliferative activity, our goal is to prepare new acetylenic amine derivatives from the compound 2-(2-((2,6- dichlorophenyl)amino)phenyl)acetic acid using the Mannich reaction by the react salt of a carboxylic acid with propargyl bromide to produce the compound (prop-2-yn-1-yl 2-(2-((2,6- dichlorophenyl)amino)phenyl)acetate) (1), which was refluxed with a number of secondary amines and formaldehyde in presence of the copper chloride

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3

Et al., Khammas. "Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives." Baghdad Science Journal 16, no. 4(Suppl.) (2019): 1003. http://dx.doi.org/10.21123/bsj.2019.16.4(suppl.).1003.

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Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4), Reaction of 5-(P-dimethyl amine benzene)-2-amino-1,3,4- oxadiazole in the presence of potassium carbonate anhydrous to yield new compound (N-(2- aminoacetyl-5-(P-dimethyl amine benzene )-1,3,4-oxadiazoles-2-yl)(A30) and Azo compound (N-(5-(Azo-2-hydroxy-5-amino benzene)-1,3-Diazol-2yl)Allopurinol(A46). The structure of prepared compounds were c

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4

Journal, Baghdad Science. "Synthesis, Characterization and Biological Activates Studies of some New Derivatives From 2-aminoo-5-mercapto-1, 3, 4-thiadiazole." Baghdad Science Journal 15, no. 1 (2018): 48–56. http://dx.doi.org/10.21123/bsj.15.1.48-56.

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In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1, 3, 4-thiadiazole) as a starting material base. The main heterocyclic compounds (1, 3, 4-thiadiazole, oxazole) etc, 2-amino-5-mercapto-1,3,4-thiadiazole compound (1) was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of (1) via hydrogen peroxide, to have (2) which was treated with chloro acetyl chloride to get (3). Preparation of thiazole ring (4) was from reacting of (3) with thiourea. Synthesis of diazonium

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5

Garg, Ajay Kumar, Ranjan Kumar Singh, Vaibhav Saxena, Saurabh Kr Sinha, and Sanjay Rao. "Synthesis, Characterization, and Anti-inflammatory activity of Some Novel Oxazole Derivatives." Journal of Drug Delivery and Therapeutics 13, no. 1 (2023): 26–28. http://dx.doi.org/10.22270/jddt.v13i1.5719.

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A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and 1H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammato

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6

Hamid Mohammed Saleh Al-Jubori. "Synthesis And Identification Of from HEMA Schiff Base Derivatives Contains Aldehyde Group For Hexa and Hepta Cyclization." Tikrit Journal of Pure Science 22, no. 1 (2023): 83–94. http://dx.doi.org/10.25130/tjps.v22i1.612.

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In this research the polymer which contains aldehyde group [H1] has been prepared by oxidation [H] using the oxidizing agent (Dess Martin Periodinane), [H1] has been dialyzed by ethanol, Schiff bases[H2,H5andH8] compounds have been prepared through the reaction of compound [H1] with appropriate amines, [H3] compound which contains hydroquinazolin ring has been prepared by the reaction of [H2] compound with 2-amino benzoic acid.[H4]which has been prepared by cyclization reaction of compound [H2] with phthalic anhydride. compounds [H6,H7]were prepared by the reaction of [H5] compound with 2-amin

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7

Najm, Reem Suhail, Qader Abdullah Shannak, and Adil Hussein Dalaf. "Synthesis and Decoration of Aromatic Derivatives Nano Platelets by the Electric Method." Azerbaijan Pharmaceutical and Pharmacotherapy J 22, no. 2 (2023): 92–97. http://dx.doi.org/10.61336/appj/22-2-22.

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The present work consists of synthesizing a five-decorated aromatic amine derivatives. The decoration involves aromatic derivatives nano-platelets through an electric process using aromatic amine derivatives such as Sulfamethoxazole, \(2\)-Amino-\(6\)-chloro benzothiole, Trimethoprim, \(2\)-Amino benzoic acid, and \(4\)-Amino phenol. This process occurs in an electric cell containing platinum electrodes with a voltage of \(1.6\) volts, resulting in the production of compound \((R1,R5)\). These compounds were characterized and diagnosed using physical and spectroscopic methods, including infrar

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8

A. Jawad, Asmaa, and Ammar J. Alabdali. "Synthesis, Characterization and Antibacterial Activity of Some Penicillin Derivatives." Al-Nahrain Journal of Science 23, no. 4 (2020): 29–34. http://dx.doi.org/10.22401/anjs.23.4.05.

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This study illustrated the synthesis of two new di amidine compounds ([c] and [d]) by reaction of 6-amino penicillanic acid (6-APA) with diα-amino nitrile compounds ([a] and [b]). [a] and [b] di α-amino nitrile compounds synthesized from the condensation reaction on aldehyd and di amine in the presence of potassium cyanid as one pot-three components reaction. The new di amidine compounds ([c] and [d]) have been proven their efficiency by inhibiting some types of bacteria (Staphylococcus aurous, Streptococcus, Escherichia coliand klebsiella). Amidine compound [d] showed better effect than [c] a

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9

Al-Bahrani, Hussein Ali, Mohanad Mousa Kareem, Abdul Amir Kadhum, and Nour A. Alrazzak. "Synthesis and Characterization of New Zinc Phthalocyanine - Dodecenyl Succinic Anhydride Benzoic Groups." Current Organic Synthesis 17, no. 6 (2020): 488–95. http://dx.doi.org/10.2174/1570179417666200519091950.

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Background: The phthalocyanines a series of compounds involves four iso-indole units linked by aza nitrogen atoms bonded with metal atoms that are normally located in the center a phthalocyanines ring. Some of the central metal-phthalocyanines can be excited by ultraviolet light and emit a fluorescence in far-red region. Objective: To synthesize a derivative of phthalocyanines namely 4,4',4' '-tri-(dodecenyl succinic anhydride)- 4' ' '-(5-amino salicylic acid) zinc phthalocyanine with a zinc central metal. Materials and Methods: The reaction of 4- nitro Phthalonitrile and 4- amino Phthalonitri

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10

Mageed, Fatimah Abdul Razzak, Zena T. Omran, and Shatha Abd Al-Jabbar. "Preparation and Characterization of a New Polymer for Mesalazine and Study of its Biological Activity against Colon Cancer." Cognizance Journal of Multidisciplinary Studies 5, no. 1 (2025): 139–46. https://doi.org/10.47760/cognizance.2025.v05i01.011.

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This work produced new homogenous and heterogeneous polymers with medical qualities to expand the controlled drug, as well as new drug-substituted monomers. The following three lines were included in this work: Preparation is the first stage (compound1) via reaction of furan-2,5-dione with 4-aminobenzoic acid, then compound (1) was reacted with amino drug such as (mesalazine) compound(2) monomer. Second line: The homogeneous polymer (compound 3) was produced by employing MEKP as an initiator in the polymerase reaction of the monomer's (compound 2) free radicals under nitrogen. Third line: Usin

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11

Fatimah, Abdul Razzak Mageed, T. Omran Zena, and Abd Al-Jabbar Shatha. "Preparation and Characterization of a New Polymer for Mesalazine and Study of its Biological Activity against Colon Cancer." Cognizance Journal of Multidisciplinary Studies (CJMS) 5, no. 1 (2025): 139–46. https://doi.org/10.47760/cognizance.2025.v05i01.011.

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This work produced new homogenous and heterogeneous polymers with medical qualities to expand the controlled drug, as well as new drug-substituted monomers. The following three lines were included in this work:<strong> </strong>Preparation is the first stage (compound1) via reaction of furan-2,5-dione with 4-aminobenzoic acid, then compound (1) was reacted with amino drug such as (mesalazine) compound(2) monomer.<strong> </strong>Second line: The homogeneous polymer (compound 3) was produced by employing MEKP as an initiator in the polymerase reaction of the monomer's (compound 2) free radical

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12

Firdaus, Firdaus, Jumina Jumina, and Hardjono Sastrohamidjojo. "EFFECT OF DE-tert-BUTYLATION AND FUNCTIONALIZATION WITH AMINE GROUPS AT THE UPPER RIM OF p-tert-BUTYLCALIX[4]ARENE TO THE EXTRACTABILITY FOR Cr³⁺, Cd²⁺ and Pb²⁺ IONS." Indonesian Journal of Chemistry 7, no. 3 (2010): 289–96. http://dx.doi.org/10.22146/ijc.21671.

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The effects to the extractability forwards Cr3+, Cd2+, and Pb2+ ions of de-tert-butylation and functionalization with amine groups at the upper rim of p-tert-butylcalix[4]arene had been studied by applied the p-tert-butylcalix[4]arene (1), tetrahydroxycalix[4]arene (2), and p-(amino)butoxycalixarene (3) compounds as extractants for the heavy metals ions. The extraction involved optimise of three parameters, i.e. pH, time, and concentration of extractants. The extraction degrees of the heavy metals ions at optimum conditions were compared each other to decide the effects. Compound 1 showed high

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13

Veeranki, Krishna Chaitanya, Jalapathi Pochampally, and Ravi Chander Maroju. "Synthesis of Novel Biaryl Fused Thiazolo[3,2-b][1,2,4]triazol-2-amines from Thiazole Amine Involving Suzuki Coupling Reaction under Microwave Irradiation." Asian Journal of Chemistry 35, no. 2 (2023): 431–34. http://dx.doi.org/10.14233/ajchem.2023.26998.

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Novel series of fused heterocycles in which amino triazole fused to biphenyl thiazole were synthesized in a multistep reaction starting from 2-aminothiazole. The amino compound with ethoxy carbonyl isothiocyanate afforded the ethyl carbamate thiomide derivative of thiazole, which further underwent intramolecular cyclization with hydroxyl amine hydrochloride in presence of DIPEA to furnish the fused thiazolotriazole amine. Haloaryl group in the fused heterocycle under Suzuki coupling condition afforded biphenyl derivatives of fused thiazolotriazole amines. All the synthesized compounds were con

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14

Reddy, B. Siva, and K. R. S. Prasad. "Design, Synthesis and Antibacterial Activity of N-(3-((4-(6-(2,2,2- Trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-yl)amide Derivatives." Asian Journal of Chemistry 33, no. 3 (2021): 577–82. http://dx.doi.org/10.14233/ajchem.2021.23039.

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A new series of N-(3-((4-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3- yl)amide derivatives (10a-h)were synthesized by the reaction of 3-((4-(6-(2,2,2-trifluoroethoxy)pyridin- 3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-amine (8) with various carboxylic acids in the presence of T3P catalyst. The reaction is usually furnished within 60 min with good isolated yields. Coupling of 6-(2,2,2-trifluoroethoxy) nicotinic acid (1) with Weinreb amine hydrochloride gave N-methoxy-Nmethyl- 6-(2,2,2-trifluoroethoxy) nicotinamide (2). Compound 3 was synthesized by the Grignard reaction

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15

Martin, Dierk, and Eckhard Schlimme. "Preparation of Ureidonucleosides of the Threonine Isomers." Zeitschrift für Naturforschung C 49, no. 11-12 (1994): 834–42. http://dx.doi.org/10.1515/znc-1994-11-1219.

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The hypermodified ureidonucleoside N6[((9-β-ᴅ-ribofuranosyl-9H-purine-6-yl)amino)carbonyl]- ʟ-threonine (5) is a constituent of transfer ribonucleic acid (tRNA) and is secreted as a tRNA catabolite in body fluids such as blood, milk and urine. Compound 5 and the isomeric ureidonucleosides bearing ᴅ-threonine (9), ʟ-allo- (7) and ᴅ-allo-threonine (11) as side chain moieties were synthesized on a preparative scale. The amido protons of 5 and 9 cause two separate 1H NMR signals whereas 7 and 11 cause multiplets. The 13C NMR signals of all carbon atoms of the allo-amino acid side chains (7, 11) ar

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16

Tolba, Mahmoud S., Mostafa Sayed, Shaban A. A. Abdel-Raheem, Taher A. Gaber, Adel M. Kamal El-Dean, and Mostafa Ahmed. "Synthesis and spectral characterization of some new thiazolopyrimidine derivatives." Current Chemistry Letters 10, no. 4 (2021): 471–78. http://dx.doi.org/10.5267/j.ccl.2021.4.004.

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Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared in literature. The starting compound was allowed to react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives (2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with benzaldehyde while amino-dicarbonit

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17

Julianto, T. S., F. J. Rachmawaty, H. A. Tamhid, and B. S. Putri. "THE POTENTIAL ANTIMALARIAL DRUG OF ARYL AMINO ALCOHOL DERIVATIVES FROM EUGENOL: SYNTHESIS, in-vitro AND in-silico ANALYSIS OF BIOACTIVITY." RASAYAN Journal of Chemistry 16, no. 03 (2023): 1425–34. http://dx.doi.org/10.31788/rjc.2023.1636940.

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Malaria is a significant cause of death in numerous countries, and the discovery of effective drugs is crucial. In this research, a new method was employed to synthesize a derivative of aryl amino alcohol using eugenol. Initially, an epoxide compound called 2-methoxy-4-(oxiran-2-ylmethyl) phenol was synthesized from eugenol by reacting it with peroxyacetic acid in dichloromethane. Subsequently, the epoxide compound was subjected to a reaction with various amine compounds, including aniline, naphthylamine, and diphenylamine for 10 minutes under 100 W microwave conditions, resulting in the produ

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18

Journal, Baghdad Science. "Synthesis of some Heterocyclic Compounds Derived from." Baghdad Science Journal 10, no. 3 (2013): 525–36. http://dx.doi.org/10.21123/bsj.10.3.525-536.

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The 4-(?-bromo acetyl)-4?-toluene sulfonanilide (2) was used as key intermediate to synthesize new heterocyclic compounds. This bromo compound was synthesized via sulfonation of amino group of p-amino acetophenone using Hinsburg method with 4-toluene sulfonyl chloride to form 4-acetyl-4?-toluene sulfonanilide (1) which is used as a starting material in this work. This compound was brominated to yield compound (2) which is used as a precursor to synthesize new five and seven membered heterocyclic compounds such as substituted 1,3-oxazoles (3,4), 1,3-thiazole derivatives (5-7), thiourea compound

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19

Lu, Chao-Fan, Sheng-Hui Wang, Xiao-Jing Pang, et al. "Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents." Molecules 25, no. 23 (2020): 5530. http://dx.doi.org/10.3390/molecules25235530.

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Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy. Aiming to continue the research of effective chalcone derivatives to treat cancers with potent anticancer activity, fourteen amino chalcone derivatives were designed and synthesized. The antiproliferative activity of amino chalcone derivatives was studied in vitro and 5-Fu as a control group. Some of the compounds showed moderate to good activity against three human cancer cells (MGC-803, HCT-116 and MCF

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20

Athmani, Hamza, and Nourreedine Benali-Cherif. "Structure and thermal analysis of amino acids." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C989. http://dx.doi.org/10.1107/s205327331409010x.

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The twenty amino acids are chemical compounds having two functional groups (carboxyl:-COOH, amine:-NH2) and an asymmetric carbon (except glycine). They are amphoteric and can exist as zwitterion. Because of the reactivity of amino acids (esterification, amidation, N-alkylisation, N-arylation, protonation), and their conformation (aliphatic, aromatic) chemical, properties (acid, base, and / or hydroxylated, solubility), and physical properties (absorbance, NLO), our laboratory contribute to the study (synthesis and X ray single crystal structures) of new organic-inorganic hybrid compounds which

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21

Haggam, Reda Ahmed, Mohamed Gomma Assy, Mohamed Hassan Sherif, and Mohamed Mohamed Galahom. "A series of 1,3-imidazoles and triazole-3-thiones based thiophene-2-carboxamides as anticancer agents: Synthesis and anticancer activity." European Journal of Chemistry 9, no. 2 (2018): 99–106. http://dx.doi.org/10.5155/eurjchem.9.2.99-106.1701.

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By addition of semicarbazide or phenylhydrazine hydrochloride to thienoylisothiocyanate (1) resulted in building of thiosemicarbazide derivative (2), triazole derivative (4) and thiophene-2-carboxamide (5), respectively. Basic cyclization of compound 2 led to formation of oxadiazine (3). Synthesis of thiadiazine derivative (6) was achieved via reaction of compound 5 and maleic anhydride in triethyl amine. Heating of compound 5 with ethyl chloroacetate or sodium ethoxide produced thiadiazine derivative (7) and triazolethione (8), respectively. Thiosemicarbazide derivative 11 was synthesized by

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22

Saad, Hala Abdel Rahim, Raied Mustafa Shakir, and Mohammad Hady Mahdi. "Synthesis and Thermal Electo Conductivity of Some New Triazole Derivatives Bearing Azo or Azomethain Group." Ibn AL- Haitham Journal For Pure and Applied Science 31, no. 3 (2018): 88. http://dx.doi.org/10.30526/31.3.2018.

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Newly acid hydrazide was synthesized from ethyl 2-(2,3-dimethoxyphenoxy) acetate (2), which is cyclized to the corresponding 4-amino-1,2,4-triazole (3). Five newly azo derivatives (4a-e) were synthesized from this 1,2,4-triazole by converting the amine group to diazonium salt then reacted with various substituent phenol,as well three newly imine derivatives (5a-c) were synthesized from reacting the amine group of compound (3) with three aryl aldehyde. The thermal electro conductivity of these compounds was tested at 30, 50, 75 and 100 ᵒC. compound 4a showed interesting electro conductivity at

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23

Butcher, Ray J., Greg Brewer, Aaron S. Burton, and Jason P. Dworkin. "Isovaline monohydrate." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1829—o1830. http://dx.doi.org/10.1107/s1600536813031620.

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The title compound, C5H11NO2·H2O, is an isomer of the α-amino acid valine that crystallizes from water in its zwitterion form as a monohydrate. It is not one of the 20 proteinogenic amino acids that are used in living systems and differs from the natural amino acids in that it has no α-H atom. The compound exhibits hydrogen bonding between the water molecule and the carboxylate O atoms and an amine H atom. In addition, there are intermolecular hydrogen-bonding interactions between the carboxylate O atoms and amine H atoms. In the crystal, these extensive N—H...O and O—H...O hydrogen bonds lead

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24

Aldibashi, Fatma Masoud. "MOLECULAR STRUCTURE AND ELECTRONIC PROPERTIES OF SOME PHENYLALANINE DERIVATIVES AS TRYPTOPHAN HYDROXYLAS (TPH) INHIBITORS." International Journal of Engineering Applied Sciences and Technology 8, no. 1 (2023): 160–63. http://dx.doi.org/10.33564/ijeast.2023.v07i12.028.

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In this work a theoretical study related to exploring and establishing the relationship between geometry, electronic structure, and various physical properties were determined for two substituted phenylalanine derivatives as tryptophan hydroxylase (TPH) inhibitors; 2-Amino-3-(4-(5-(Naphthalen-2- Ylmethyl-amino) Pyrazin-2-Yl) Phenyl) Propionic Acid and -2-Amino-3-(4-{5-[(Quinolin-3-Ylmethyl)-Amino]- Pyrazin-2-Yl} Phenyl) Propionic Acid, which differ structurally, that carbon atom of naphthalene in compound 1 is replaced by nitrogen atom to form quinine in compound 2. Molecular properties such a

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25

Atalla, Ahmed A., Adel M. Kamal El-Dean, and Abd El-Fattah A. Harb. "Synthesis of some new heterocyclic compounds containing chromene." Collection of Czechoslovak Chemical Communications 56, no. 4 (1991): 916–22. http://dx.doi.org/10.1135/cccc19910916.

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2-amino-3-cyano-4H-phenyl-benzo[f]chromene (I) was reacted with formamide, acetic anhydride, and ethyl cyanoacetate to produce compounds (II-IV), respectively. Compound IV reacted with HCONH2, POCl3 and P2S5 to produce corresponding pyrimidobenzochromene (V), chloropyridobenzochromene (VI) and mercaptopyridobenzochromene (VII). Compound VII reacted with α-halocompounds to produce corresponding S-alkylated derivatives (VIIIa to VIIIc), and compound (VI) reacted with different amines to produce corresponding alkyl amino-, or aryl aminopyridobenzochromene (IXa-IXc) but in using hydrazine hydrate,

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26

Park, Sung Chul, Jung-Ho Lee, Ji-Yeon Hwang, et al. "Ochraceopetalin, a Mixed-Biogenetic Salt of Polyketide and Amino Acid Origins from a Marine-Derived Aspergillus ochraceopetaliformis Fungus." Marine Drugs 19, no. 8 (2021): 413. http://dx.doi.org/10.3390/md19080413.

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Ochraceopetalin (1), a mixed-biogenetic salt compound and its component 2 were isolated from the culture broths of a marine-derived fungus, Aspergillus ochraceopetaliformis. Based on combined spectroscopic and chemical analyses, the structure of 1 was determined to be a sulfonated diphenylether-aminol-amino acid ester guanidinium salt of an unprecedented structural class, while 2 was determined to be the corresponding sulfonated diphenylether. Ochraceopetaguanidine (3), the other guanidine-bearing aminol amino acid ester component, was also prepared and structurally elucidated. Compound 1 exhi

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27

Aliyazicioglu, Rezzan, Merve Yikilmaz, Seyda Kanbolat, Merve Badem, Seda Fandakli, and Sengul Alpay Karaoglu. "Antioxidative and Antimicrobial Activity of 2-Amino Substituted Halochalcone N-Glycoside Derivative Compounds." Pharmedicine Journal 1, no. 3 (2024): 121–27. http://dx.doi.org/10.62482/pmj.13.

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Introduction: The aim of this study was to specify the antioxidant and antimicrobial activity synthesized 2-amino substituted halochalcone N-glycoside derivative compounds. Methods: The antioxidant capacity of synthesized compounds (1-4) was determined by cupric ion reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP). Antimicrobial activity was determined on 9 microorganism by agar well diffusion method.Results: According to the study results, compound 3 showed the highest antioxidant activity. The compound 3 showed antimicrobial activity against Yersinia pseud

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28

E., Adewole, Oke O.T., and Ojo A. "Synthesis of 8-Methoxyquinoline-5-Amino Acetic Acid and its Herbicidal Potential." Journal of Advance Research in Applied Science (ISSN: 2208-2352) 2, no. 4 (2015): 01–15. http://dx.doi.org/10.53555/nnas.v2i4.679.

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The quinoline skeleton is often used for the design of many synthetic compounds with diverse pharmacological properties. 8-Methoxyquinoline 5-amino acetic acid was synthesized from coupling of monochloroacetic acid with 5-amino-8-methoxyquinoline. The IR showed – OH stretch absorption and amino group (-NH) which is not too prominent at 3450cm-1 and 3300cm-1, carbonyl (C=O) absorption depicts at 1614cm-1. The herbicidal activity of the synthesized compound was tested on the weeds and after 11 days of application, the weeds have dried completely indicating the efficacy of the compound.

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29

Sathe, B. S., E. Jaychandran, G. M. Sreenivasa, and V. A. Jagtap. "Antimycobacterial Activity of Some Synthesized Fluorinated Benzothiazolo Imidazole Compounds." E-Journal of Chemistry 8, no. 2 (2011): 830–34. http://dx.doi.org/10.1155/2011/581429.

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4-Fluoro-3-chloroanilline treated with potassium thiocyanate in presence of glacial acetic acid and bromine was converted into 2-amino-6-fluoro-7-chlorobenzothiazole, resulting into 2-amino benzothiazole. The synthesized compound in presence of 2-phenyl-4-benzylidine-5-oxazolinone refluxed in pyridine to obtain 2-(2-phenyl-4-benzylidenyl-5-oxo-imidazolin-1-yl amino)-6-fluoro-7-substituted(1,3)benzothiazoles. The above said compound was treated withortho, metaandpara nitroanillines, ortho, meta, parachloroanillines, morpholino, piperazine, diphenylamine in the presence of DMF to obtain differen

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M. Alwan, Shakir, and Sarrah S. Jabbar. "Design, Synthesis and Preliminary Antimicrobial Evaluation of New Derivatives of Cephalexin." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 24, no. 1 (2017): 85–91. http://dx.doi.org/10.31351/vol24iss1pp85-91.

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There is a continuous and massive need for newer cephalosporins that should have resistance against Î²-lactamases and can be used orally. An approach of using cephalexin, as a well-studied and potent antibacterial compound is considered to prepare new designed derivatives. These derivatives include the incorporation of amino acid moiety linked through an amide bond with the Î±-amino group of cephalexin. Certain aliphatic amino acids were used, such as glycine, alanine, valine and proline. The chemical structures of these derivatives were confirmed by IR spectroscopy and elemental analyses. All

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Mavrova, Anelia, Stephan Dimov, Inna Sulikovska, et al. "Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines." Molecules 27, no. 10 (2022): 3314. http://dx.doi.org/10.3390/molecules27103314.

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Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were tested in vitro against human and mouse cell lines. The examination of the compound effects on BLAB 3T3 and MFC-10A cells showed that they are safe, making them suitable for subsequent experiments to establish their antitumor activity. The photoirritancy factor of the compounds was calculated. Using

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Song, Sanghoon, Gyeongdong Yeom, Donghyuk Kim, et al. "Effects of the Diamine Chain End Functionalized Liquid Butadiene Rubber as a Processing Aid on the Properties of Carbon-Black-Filled Rubber Compounds." Polymers 14, no. 16 (2022): 3343. http://dx.doi.org/10.3390/polym14163343.

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The implementation of vehicle electrification and autonomous driving technologies has recently emphasized the importance of abrasion resistance and fuel efficiency of truck bus radial (TBR) tire treads that undergo high loads and long driving times. In this study, a functionalized liquid butadiene rubber (F-LqBR) was introduced to replace the treated distillate aromatic extracted (TDAE) oil as a way to improve abrasion resistance and fuel efficiency in the TBR tire tread compound and to solve the oil migration. First, radical polymerization was used to synthesize nonfunctionalized LqBR (N-LqBR

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Gómez-Pérez, Verónica, José Ignacio Manzano, Raquel García-Hernández, Santiago Castanys, Joaquín M. Campos Rosa, and Francisco Gamarro. "4-Amino Bis-Pyridinium Derivatives as Novel Antileishmanial Agents." Antimicrobial Agents and Chemotherapy 58, no. 7 (2014): 4103–12. http://dx.doi.org/10.1128/aac.02481-13.

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ABSTRACTThe antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of pentamidine have been investigated, and all compounds assayed were found to display activity against promastigotes and intracellular amastigotes ofLeishmania donovaniandLeishmania major, with 50% effective concentrations (EC50s) lower than 1 μM in most cases. The majority of compounds showed similar behavior in bothLeishmaniaspecies, being slightly more active againstL. majoramastigotes. However, compound VGP-106 {1,1′-(biphenyl-4,4′-diylmethylene)bis[4-(4-bromo-N-methylanilino)pyridinium] dibr

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Weni, Mustika, Mega Safithri, and Djarot Sasongko Hami Seno. "Molecular Docking of Active Compounds Piper crocatum on the A-Glucosidase Enzyme as Antidiabetic." Indonesian Journal of Pharmaceutical Science and Technology 7, no. 2 (2020): 64. http://dx.doi.org/10.24198/ijpst.v7i2.21120.

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Ethanol extract of Piper crocatum leaves has inhibitory activity of α-glucosidase enzyme. Ethyl acetate fraction from Piper crocatum leaves has the highest antioxidant activity. Previous research has provided information that the ethyl acetate fraction of Piper crocatum leaves has an inhibition of α-glucosidase containing 6XO32ZSP1D, Ethyl L-serinate hydrochloride compound, Schisandrin B compound, Columbin compound, 4- (4-methoxy-phenylamino) -2 compound, 3-dihydro-1H-4a, 9-diazacyclopenta (b) fluorine-10-carbonitrile, compound 6-Amino-4- [3- (benzyloxy) phenyl] -3-tert-butyl-2,4-dihydropyrano

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Abdullaeva, Zh, and Zh Dzhumaeva. "Structure of Manganese Chloride and Threonine Crystals Formed by Slow Vaporization Method." Bulletin of Science and Practice 10, no. 6 (2024): 15–19. http://dx.doi.org/10.33619/2414-2948/103/01.

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Crystals of complex compounds are used in technology, optics, medicine, pharmacy, surface treatment, etc. The study of the crystal structure of complex compounds is important because they are widely used in industry and exhibit mechanical, thermal and a number of other valuable properties. Study of the crystal structure of complex compound of manganese chloride with the amino acid threonine, as well as the study of its physicochemical and biological properties. For the synthesis of complex compound, the method of slow evaporation was used. The composition of the formed crystals of the compound

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Zaki, Dr Remon M., Prof Adel M. Kamal El-Dean, Dr Nermin A. Marzouk, Prof Jehan A. Micky, and Mrs Rasha H. Ahmed. "A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 1 (2015): 3910–18. http://dx.doi.org/10.24297/jac.v12i1.845.

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Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carb

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Sadieva, H. R., A. N. Nurlybayeva, S. T. Duysenbaeva, and N. А. Yessenzhol. "STUDY OF PHYSICO-CHEMICAL PROPERTIES OF AMINO ACIDS AND SODIUM THIOSULFATE SOLUTION." DULATY UNIVERSITY BULLETIN 2, no. 10 (2023): 107–15. http://dx.doi.org/10.55956/htzg4272.

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In this work, the composition of drugs made from amino acid compounds and thio compounds containing cysteine was studied. The structure of amino acids and sodium thiosulfate was synthesized and modern physico-chemical research methods of infrared spectroscopy, X-ray diffractometry, and pH-meter analyzes were carried out. The ability of amino acids to react with sodium thiosulfate was studied. Medicines made from thio compounds and amino acid compounds with a cysteine compound help to destroy various bacteria in the human body. Sodium thiosulfate is used in medicine to cleanse the body of toxic

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Prajapati, Devang R., Kalpesh V. Vilapara, and Yogesh T. Naliapara. "An Efficient Solid Phase One Port Synthesis of Novel Triazolo[1,5-a]Pyrimidine Derivatives from 4-(4-Aminophenyl)Morpholin-3-One and Evaluation of their Antimicrobial Activity." International Letters of Chemistry, Physics and Astronomy 33 (May 2014): 12–21. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.33.12.

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A series of novel triazolo[1,5-a]pyrimidine derivatives was synthesized from 5-amino-1,2,4-triazole and biologically active morpholinone amine in excellent yield as promising class of antimicrobial agents. The antimicrobial activities were investigated against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogen, Candida albicans, Aspergillusniger, Aspergillusclavatus and compared with standard drugs Ampicillin, Chloramphenicol, Norfloxacin and Griseofulvin. All the synthesized compounds were characterized by IR, 1H NMR, 13C and mass spectroscopy. The result o

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Prajapati, Devang R., Kalpesh V. Vilapara, and Yogesh T. Naliapara. "An Efficient Solid Phase One Port Synthesis of Novel Triazolo[1,5-a]Pyrimidine Derivatives from 4-(4-Aminophenyl)Morpholin-3-One and Evaluation of their Antimicrobial Activity." International Letters of Chemistry, Physics and Astronomy 33 (May 11, 2014): 12–21. http://dx.doi.org/10.56431/p-2k25vg.

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A series of novel triazolo[1,5-a]pyrimidine derivatives was synthesized from 5-amino-1,2,4-triazole and biologically active morpholinone amine in excellent yield as promising class of antimicrobial agents. The antimicrobial activities were investigated against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogen, Candida albicans, Aspergillusniger, Aspergillusclavatus and compared with standard drugs Ampicillin, Chloramphenicol, Norfloxacin and Griseofulvin. All the synthesized compounds were characterized by IR, 1H NMR, 13C and mass spectroscopy. The result o

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Gangadhar, S. Bhopalkar. "Synthesis and Characterization of 3-Cyano-6,9-dimethyl-4-oxo-2-methylthio- 4H-Pyrimido[2,1-b][1,3] Benzothiazole and its 2-Substituted derivatives." Chemistry Research Journal 6, no. 4 (2021): 132–35. https://doi.org/10.5281/zenodo.11758088.

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<strong>Abstract </strong>A compound 3-cyano-6, 9-dimethyl- 4-oxo 2-methylthio-4H-Pyrimido[2,1-<em>b</em>][1,3] benzothiazole 3 has been prepared by the reaction of<strong> </strong>2-amino- 4,7- dimethyl [1, 3] benzothiazole 1<strong> </strong>with Ethyl -2-cyano-3,3’-bis-methylthio acrylate 2<strong> </strong>in presence of anhydrous K<sub>2</sub>CO<sub>3</sub> in DMF. The compound pyrimido benzothiazole 3 has methylthio functional group at 2- position which was substituted by using selected nucleophiles like substituted phenols, anilines, heteryl amine and active methylene compounds t

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Jeffs, S. A., and C. Arme. "Echinococcus granulosus: specificity of amino acid transport systems in protoscoleces." Parasitology 95, no. 1 (1987): 71–78. http://dx.doi.org/10.1017/s0031182000057553.

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SUMMARYProtoscoleces ofEchinococcus granulosusabsorb the l-amino acids proline, methionine, leucine, alanine, serine, phenylalanine, lysine and glutamic acid by a combination of mediated transport and diffusion. All eight amino acids were accumulated against a concentration gradient. Comparison ofKtandVmaxvalues suggests that a low affinity for a particular compound is compensated for by a relatively larger number of transport sites for that compound. Four systems serve for the transport of the eight substrates studied: 2 for neutral (EgNl, EgN2) and 1 each for acidic (EgA) and basic (EgB) ami

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Arifian, Hanggara, Rani Maharani, Sandra Megantara, Amirah Mohd Gazzali, and Muchtaridi Muchtaridi. "Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results." Molecules 27, no. 21 (2022): 7631. http://dx.doi.org/10.3390/molecules27217631.

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Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building blocks of life and are abundantly available; thus, a greater shift can result in structural modification, since amino acids contain a variety of sidechains. This review discusses the data available on amino acid–natural compound conjugates that were reported with respect to their backgrounds, the synthe

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Shakir, Raied Mustafa, Shaimaa Abed Saoud, and Dhuha Faruk Hussain. "Synthesis, Antibacterial, and Molecular Docking Study of Novel 2-Chloro-8-Methoxy-3-Aryl-[1,3] Benzoxazine Derivatives using Vilsmeier Reagent." International Journal of Drug Delivery Technology 10, no. 03 (2020): 487–98. http://dx.doi.org/10.25258/ijddt.10.3.32.

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Reducing of ethyl 4-((2-hydroxy-3-methoxybenzylidene)amino)benzoate (1) afford ethyl 4-((2-hydroxy-3-methoxybenzyl)amino)benzoate (2). Reaction of this compound with Vilsmeier reagent affords novel 2-chloro-[1,3] benzoxazine ring (3). The corresponding acid hydrazide of compound 3 was synthesized from reaction of compound (3) with hydrazine hydrate. Newly series of hydrazones (5a–i) were synthesized from reaction of acid hydrazide with various aryl aldehydes. Antibacterial activity of the hydrazones was secerned utilizing gram-negative and gram-positive bacteria. Compound (5b) and (5c) exhibit

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Kornii, Yurii, Oleh Shablykin, Olga Shablykina, and Volodymyr Brovarets. "New 4-iminohydantoin sulfamide derivatives with antiviral and anticancer activity." Ukr. Bioorg. Acta 2021, Vol. 16, N1 16, no. 1 (2021): 10–17. http://dx.doi.org/10.15407/bioorganica2021.01.010.

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A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant

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Zhang, Qi, Yao Huang, Heran Cao, Fangyi Gong, Qingye Gan, and Beibei Mao. "Synthesis of tert-butyl 3-(2-(4-amino-3-(2-aminobenzo[d]oxazole-5-yl)-1H-pyrazole[3,4-d] pyrimidine-1-yl) ethoxy) propionate." Highlights in Science, Engineering and Technology 2 (June 22, 2022): 330–36. http://dx.doi.org/10.54097/hset.v2i.591.

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Tert-butyl 3-(2-(4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazole[3,4-d] pyrimidine-1-yl) ethoxy) propionate plays an important role in the whole synthesis route as an intermediate of target mTOR targeted PROTAC molecule PRO1. In this experiment, palladium catalyzed Suzuki reaction was used, the target compound tert-butyl 3-(2-(4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazole[3,4-d]pyrimidine-1-yl)ethoxy)propionate (compound 3) was synthesized from 5-(4,4,5,5-tetramethyl-1,3,2-dioxobenzaldehyde-2-yl) benzo[d]oxazole-2-amine (compound 1) and 3-(2-{4-amino-3-iodine-1H-pyrazole[3,4-d]pyrimidi

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Huang, Pei-Tzu, Sirle Saul, Shirit Einav, and Christopher R. M. Asquith. "Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors." Molecules 26, no. 23 (2021): 7338. http://dx.doi.org/10.3390/molecules26237338.

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Emerging viral infections, including those caused by dengue virus (DENV) and Venezuelan Equine Encephalitis virus (VEEV), pose a significant global health challenge. Here, we report the preparation and screening of a series of 4-anilinoquinoline libraries targeting DENV and VEEV. This effort generated a series of lead compounds, each occupying a distinct chemical space, including 3-((6-bromoquinolin-4-yl)amino)phenol (12), 6-bromo-N-(5-fluoro-1H-indazol-6-yl)quinolin-4-amine (50) and 6-((6-bromoquinolin-4-yl)amino)isoindolin-1-one (52), with EC50 values of 0.63–0.69 µM for DENV infection. Thes

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Shamna, Salahudeen, C. M. A. Afsina, Rose Mary Philip, and Gopinathan Anilkumar. "Recent advances and prospects in the Zn-catalysed Mannich reaction." RSC Advances 11, no. 16 (2021): 9098–111. http://dx.doi.org/10.1039/d0ra10772g.

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Amino alkylation of an acidic α-proton of a carbonyl by formaldehyde and a primary/secondary amine or ammonia, affording a β-amino-carbonyl compound also known as a Mannich base is a valuable reaction. We focus on recent advances in Zn catalysed Mannich reactions.

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Krasowska, Dorota, Nunzio Iraci, Claudio Santi, et al. "Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors." Molecules 24, no. 16 (2019): 2914. http://dx.doi.org/10.3390/molecules24162914.

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A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged

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Naik, B. D., and K. R. Desai. "Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones." E-Journal of Chemistry 1, no. 5 (2004): 263–66. http://dx.doi.org/10.1155/2004/435147.

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As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-(coumarin-3-yl)- thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activit

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Kosmulalage, Kalhari S., Shamsulhaq Zahid, Chibuike C. Udenigwe, Sarfraz Akhtar, Athar Ata, and Radhika Samarasekera. "Glutathione S-Transferase, Acetylcholinesterase Inhibitory and Antibacterial Activities of Chemical Constituents of Barleria prionitis." Zeitschrift für Naturforschung B 62, no. 4 (2007): 580–86. http://dx.doi.org/10.1515/znb-2007-0417.

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Phytochemical studies on the ethanolic extract of Barleria prionitis of Sri Lankan origin have resulted in the isolation of a new compound, balarenone (1), along with three known compounds, pipataline (2), lupeol (3) and 13,14-seco-stigmasta-5,14-diene-3-α-ol (4). The structures of 1 - 4 were elucidated with the aid of extensive NMR spectroscopic studies. Compounds 1 - 4 showed moderate inhibitory activity against glutathione S-transferase (GST) and acetylcholinesterase (AChE). Compounds 1, 2 and 4 also exhibited antibacterial activity against Bacillus cereus and Pseudomonas aeruginosa (25 μg/

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