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Journal articles on the topic 'Aminothiazole Derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Farouk Elsadek, Mohamed, Badreldin Mohamed Ahmed, and Mohamed Fawzi Farahat. "An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities." Molecules 26, no. 5 (2021): 1449. http://dx.doi.org/10.3390/molecules26051449.

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Amongst sulfur- and nitrogen-containing heterocyclic compounds, the 2-aminothiazole scaffold is one of the characteristic structures in drug development as this essential revelation has several biological activities abiding it to act as an anticancer, antioxidant, antimicrobial and anti-inflammatory agent, among other things. Additionally, various 2-aminothiazole-based derivatives as medical drugs have been broadly used to remedy different kinds of diseases with high therapeutic influence, which has led to their wide innovations. Owing to their wide scale of biological activities, their struct

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2

Tejashree, Deokule. "1,3,4-Thiadiazole and its Derivatives: A Versatile Moiety." Medicinal Chemistry 13, no. 1 (2023): 9. https://doi.org/10.37421/2161-0444.2023.13.660.

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The evaluation of thiazole's biological activity, such as antibacterial, antiprotozoal, antitubercular, antifungal and anthelmintic, with an emphasis on their potential medicinal applications, is desirable because the thiazole has an important component effect on the pharmacophores of a large number of medicinally significant molecules. We are particularly interested in investigating newly synthesized aminothiazoles, particularly 2-aminothiazole derivatives, a class of heterocyclic ring systems with antiviral, antimicrobial, anticancer and anti-inflammatory properties, respectively. Numerous h

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3

Yarosh, N. O., I. A. Dorofeev, and L. V. Zhilitskaya. "Organosilicon derivatives based on 2-aminothiazolium cations." Журнал органической химии 59, no. 5 (2023): 588–95. http://dx.doi.org/10.31857/s051474922305004x.

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The reactions of 2-aminothiazole and 2-aminobenzothiazole with (iodomethyl) derivatives of silanes in the absence of a base gave the previously unknown organosilicon salts and ionic liquids of 2-aminothiazole and 2-aminobenzothiazole. Structure of the obtained compounds was proved by NMR, and UV spectroscopy methods.

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4

Farzaliyev, V. M., M. T. Abbasova, B. G. Babaeva, et al. "N-ALKOXYMETHYL DERIVATIVES OF 2-AMINOTHIAZOLE AND THEIR PROTECTIVE PROPERTIES." Chemical Problems 18, no. 4 (2020): 427–35. http://dx.doi.org/10.32737/2221-8688-2020-4-427-435.

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Conditions for alkoxymethylation of 2-aminothiazole with semiformals obtained by the interaction of aliphatic alcohols with formaldehyde were worked out. Alkoxymethylation was performed by means of preliminary preparation of the semiformal of appropriate hydroxylcontaining compounds followed by interaction of semiformal with equimolar amount of 2- aminothiazole. The structure of the obtained compounds was acknowledged by means of IR and NMR 1 H spectroscopy. It was established that the reaction of the alkoxymethylation proceeds in the amino form of the starting 2-aminothiazole to form an appro

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5

Abdulhadi, Shayma L., Maadh Q. Abdulkadir, and May M. Al-Mudhafar. "The Importance of 2-AminoThiazole Schiff Bases as Antimicrobial and Anticancer Agents." Al-Mustansiriyah Journal of Science 31, no. 3 (2020): 46. http://dx.doi.org/10.23851/mjs.v31i3.865.

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The pharmacophore 2-aminothiazole has an interesting role in pharmaceutical chemistry as this led to the synthesis of many types of compounds with diverse biological activity. Schiff base derivatives at the same time contribute to drug evolution importantly. In this review, the Schiff base derivatives of 2-aminothiazole formed and some of their metal complexes are being focused on, and the antimicrobial and anticancer activity of them is being illustrated.

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6

Minickaitė, Rūta, Birutė Grybaitė, Rita Vaickelionienė, et al. "Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates." International Journal of Molecular Sciences 23, no. 14 (2022): 7688. http://dx.doi.org/10.3390/ijms23147688.

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It is well-known that thiazole derivatives are usually found in lead structures, which demonstrate a wide range of pharmacological effects. The aim of this research was to explore the antiviral, antioxidant, and antibacterial activities of novel, substituted thiazole compounds and to find potential agents that could have biological activities in one single biomolecule. A series of novel aminothiazoles were synthesized, and their biological activity was characterized. The obtained results were compared with those of the standard antiviral, antioxidant, antibacterial and anticancer agents. The c

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7

Zav'yalov, S. I., N. E. Kravchenko, G. I. Ezhova, L. B. Kulikova, A. G. Zavozin, and O. V. Dorofeeva. "Synthesis of 2-aminothiazole derivatives." Pharmaceutical Chemistry Journal 41, no. 2 (2007): 105–8. http://dx.doi.org/10.1007/s11094-007-0023-4.

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8

Pattan, S. R., S. H. Kale, R. A. Mali, et al. "SYNTHESIS AND EVALUATION OF SOME SUBSTITUTED 2-AMINOTHIAZOLE DERIVATIVES FOR THEIR ANTITUBERCULAR, ANTIMICROBIAL & ANTIFUNGAL ACTIVITY." INDIAN DRUGS 49, no. 01 (2012): 24–32. http://dx.doi.org/10.53879/id.49.01.p0024.

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Millions of people are affected by infectious diseases caused by micro-organisms. Further the widespread microbial resistance had renewed the interest in quest for new antitubercular, antimicrobial & antifungal agents. The present study deals with synthesis & evaluation of some substituted 2-aminothiazole derivatives for their antitubercular, antimicrobial and antifungal activity. 2-aminothiazole derivatives were synthesized by treating substituted acetophenones with thiourea in presence of bromine to give 2-amino 4-substituted phenylthizole and then further treated with chloracetyl ch

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9

Samadhiya, Pushkal, Ritu Sharma, Santosh Srivastava, and Savitri Srivastava. "Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity." Journal of the Serbian Chemical Society 77, no. 5 (2012): 599–605. http://dx.doi.org/10.2298/jsc110616002s.

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A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the final synthesized compounds 4(a-m) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi and antitubercular activity screened against M. tuberculosis with their MIC value. Antiinflammatory activity screened against al

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10

Uchikawa, Osamu, Kohji Fukatsu, and Tetsuya Aono. "Aminothiazole derivatives.I.A convenient synthesis of monocyclic and condensed 5-aminothiazole derivatives." Journal of Heterocyclic Chemistry 31, no. 4 (1994): 877–87. http://dx.doi.org/10.1002/jhet.5570310432.

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11

B., C. JOSHI, GOGIA SANTOSH, and KISHORE DHARMA. "Conversion of Thiochroman-4-one into the corresponding Spiro-thiazole and -pyrimidine Derivatives." Journal of Indian Chemical Society Vol. 65, Apr 1988 (1988): 280–81. https://doi.org/10.5281/zenodo.6035800.

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Chemistry Department, University of Rajasthan, Jaipur-302 004 Chemistry Department, Banasthali Vidyapith, Banasthali-304 022 <em>Manuscript received 9 September 1987, revised 20 January 1988, accepted 27 </em>January <em>1988</em> Reaction of cysteine and 2-aminothiophenol with thiochroman-4-one gives thiazoline and benzothiazoline derivatives 1 and 2, respectively. Thiochroman-4-one with bromine and thiourea forms 2-aminothiazole derivative (3). Thiochroman-4-one with urea and thiourea in the presence of benzaldehyde gives pyrimidine derivatives 4 and 5, respectively.  

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12

Alghamdi, Adel, Amr S. Abouzied, Abdulwahab Alamri, et al. "Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors." Current Issues in Molecular Biology 45, no. 2 (2023): 1422–42. http://dx.doi.org/10.3390/cimb45020093.

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Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors. Thus, in this paper, we designed, synthesized, and characterized a novel series of N-aminothiazole-hydrazineethyl-pyridines, beginning with a N′-(1-(pyridine-3-yl)ethylidene)hydrazinecarbothiohydrazide derivative and various hydrazonoyl chlorides and phenacyl bromides. Their Schiff bases were prepared from the condensation of N-aminothiazole derivatives with 4-methoxybenzaldehyde. FTIR, MS, NMR, and elemental studies were used to identify

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13

Toplak, Renata, Nina Lah, Julija Volmajer, Ivan Leban, and Alenka Majcen Le Maréchal. "2-Aminothiazole and 2-aminothiazolinone derivatives." Acta Crystallographica Section C Crystal Structure Communications 59, no. 9 (2003): o502—o505. http://dx.doi.org/10.1107/s0108270103015580.

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14

UCHIKAWA, O., K. FUKATSU, and T. AONO. "ChemInform Abstract: Aminothiazole Derivatives. Part 1. A Convenient Synthesis of Monocyclic and Condensed 5-Aminothiazole Derivatives." ChemInform 26, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199513154.

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15

Hussein, Abdel Haleem M., Ahmed A. Khames, Abu-Bakr A. El-Adasy, et al. "Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors." RSC Advances 10, no. 50 (2020): 29723–36. http://dx.doi.org/10.1039/d0ra05561a.

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16

Kakati, Praachi, Preeti Singh, Priyanka Yadav, and Satish Kumar Awasthi. "Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives." New Journal of Chemistry 45, no. 15 (2021): 6724–38. http://dx.doi.org/10.1039/d1nj00280e.

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17

Ishegbe, J. E*1 Bello K. A2 Nkeonye P. O3 &. Kogo A. A.4. "SYNTHESIS AND ABSORPTION SPECTRA OF 4-PHENYL SUBSTITUTED -2-AMINOTHIAZOLES INTERMEDIATES FOR ORGANIC SYNTHESIS." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES6 7, no. 2 (2020): 14–17. https://doi.org/10.5281/zenodo.3677550.

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A series of4-aryl-2-aminothiazole derivatives were synthesized with an objective to develop novel and potent coupling components of synthetic origin as well as in dye synthesis. The required derivatives of 4-phenylsubstituted-2-aminothiazole were synthesized via a multicomponent condensation between thiourea, acetophenone and iodine. The intermediates were obtained using acetophenone and various substitute daldehydes to synthesize the intermediates which on cyclization with sulphur yielded the final products. Synthesized compounds were purified, characterized and evaluated for their spectra pr

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18

Kadam, Shuddhodan N., Ajay N. Ambhore, Rahul D. Kamble, et al. "Metal-free efficient thiolation of C(sp2) functionalization via in situ-generated NHTS for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole." New Journal of Chemistry 45, no. 10 (2021): 4632–37. http://dx.doi.org/10.1039/d0nj05904h.

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A direct metal-free approach for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole derivatives at room temperature is reported via an in situ-generated electrophilic thiolating agent.

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19

于, 丽杰. "Study on the Synthesis of Aminothiazole Derivatives." Hans Journal of Medicinal Chemistry 09, no. 02 (2021): 14–27. http://dx.doi.org/10.12677/hjmce.2021.92003.

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20

Lynch, Daniel E., Laura J. Nicholls, Graham Smith, Karl A. Byriel, and Colin H. L. Kennard. "Molecular co-crystals of 2-aminothiazole derivatives." Acta Crystallographica Section B Structural Science 55, no. 5 (1999): 758–66. http://dx.doi.org/10.1107/s0108768199003146.

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A series of molecular adducts of 2-aminothiazole derivatives – 2-aminothiazole, 2-amino-2-thiazoline and 2-aminobenzothiazole with the carboxylic-acid-substituted heterocyclics indole-2-carboxylic acid, N-methylpyrrole-2-carboxylic acid and thiophene-2-carboxylic acid – have been prepared and characterized using X-ray powder diffraction and in five cases by single-crystal X-ray diffraction methods. These five compounds are the adducts of 2-amino-2-thiazolium with indole-2-carboxylate [(C3H7N2S)+(C9H6NO2)−], and N-methylpyrrole-2-carboxylate [(C3H7N2S)+-(C6H6NO2)−], 2-aminobenzothiazolium with

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21

Panico, Anna Maria, Athina Geronikaki, Remi Mgonzo, Venera Cardile, Barbara Gentile, and Irini Doytchinova. "Aminothiazole derivatives with antidegenerative activity on cartilage." Bioorganic & Medicinal Chemistry 11, no. 13 (2003): 2983–89. http://dx.doi.org/10.1016/s0968-0896(03)00149-4.

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22

Zav'yalov, S. I., O. V. Dorofeeva, E. E. Rumyantseva, et al. "ChemInform Abstract: Synthesis of 2-Aminothiazole Derivatives." ChemInform 32, no. 47 (2010): no. http://dx.doi.org/10.1002/chin.200147105.

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23

S. Hmood, Kasim, and Amer N. Elias. "Synthesis, Characterization, and Antimicrobial Evaluation of New Ceftriaxone Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 75–88. http://dx.doi.org/10.31351/vol23iss2pp75-88.

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The present study was designed to synthesize a number of new Ceftriaxone derivatives by its involvement with a series of different amines, through the chemical derivatization of its 2-aminothiazolyl- group into an amide with chloroacetyl chloride, which on further conjugation with these selected amines will produce compounds with pharmacological effects that may extend the antimicrobial activity of the parent compound depending on the nature of these moieties. Ceftriaxone was first equipped with a spacer arm (linker) by the action of chloroacetyl chloride in aqueous medium and then furth

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24

Veeranki, Krishna Chaitanya, Jalapathi Pochampally, and Ravi Chander Maroju. "Synthesis of Novel Biaryl Fused Thiazolo[3,2-b][1,2,4]triazol-2-amines from Thiazole Amine Involving Suzuki Coupling Reaction under Microwave Irradiation." Asian Journal of Chemistry 35, no. 2 (2023): 431–34. http://dx.doi.org/10.14233/ajchem.2023.26998.

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Novel series of fused heterocycles in which amino triazole fused to biphenyl thiazole were synthesized in a multistep reaction starting from 2-aminothiazole. The amino compound with ethoxy carbonyl isothiocyanate afforded the ethyl carbamate thiomide derivative of thiazole, which further underwent intramolecular cyclization with hydroxyl amine hydrochloride in presence of DIPEA to furnish the fused thiazolotriazole amine. Haloaryl group in the fused heterocycle under Suzuki coupling condition afforded biphenyl derivatives of fused thiazolotriazole amines. All the synthesized compounds were con

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25

Ghafil, Amer, and Shaimaa Adnan. "Synthesis and Characterization of Heterocyclic Derivatives from 5-Aminotetrazole and Investigation of Their Biological Activities." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 107. http://dx.doi.org/10.59467/ijhc.2024.34.107.

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This study included the synthesis of some new heterocyclic compounds starting with 5-aminotetrazole, which reacted with 2-hydroxy-4-methoxybenzaldehyde to get compound 1. Then, 1 was converted to a Schiff base (2) derivative by reacting 1 with 2-aminothiazole. Then, compound 2 was reacted with different compounds, namely alanine, 2-mercaptoacetic acid, 2-aminobenzoic acid, phthalic anhydride, and malic anhydride, leading to the heterocyclic products imidazolidine (3), thiazolidine (4), quinazoline (5), and oxazepane (6) derivatives, respectively. All these compounds are characterized by 13C-NM

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26

Kumar, Arun, Govind Singh, and Rajiv Tonk. "Molecular Docking, Toxicity Study and Antimicrobial Assessment of Novel Synthesized 1,3-(Disubstituted)-thiazol-2-amines." Asian Journal of Chemistry 36, no. 4 (2024): 919–28. http://dx.doi.org/10.14233/ajchem.2024.31113.

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In current study, a novel analogous of substituted-2-aminothiazoles (3a-o) were synthesized through a multi-step synthetic process. Structural elucidation of these newly synthesized substituted-2-aminothiazoles were achieved using combination of analytical techniques, comprising proton nuclear magnetic resonance (PNMR), mass spectrometry and FTIR. An in vitro investigation was performed to measure the efficacy of antibacterial and antimycotic characteristics of these novel compounds (3a-o). Specifically, the growth-inhibiting action against the test fungal strains, including A. niger, M. purpu

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27

Pelit, Emel, and Zuhal Turgut. "(+)-CSA Catalyzed Multicomponent Synthesis of 1-[(1,3-Thiazol-2-ylamino)methyl]-2-naphthols and Their Ring-Closure Reaction under Ultrasonic Irradiation." Journal of Chemistry 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/9315614.

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New 1-[(1,3-thiazol-2-ylamino)methyl]-2-naphthols were obtained by condensation of 2-aminothiazole, aromatic aldehydes, and 2-naphthol in the presence of (+)-camphor-10-sulfonic acid ((+)-CSA) as an effective catalyst under ultrasound-promoted solvent-free conditions. The 1-[(1,3-thiazol-2-ylamino)methyl]-2-naphthol derivatives were converted in ring-closure reaction with formaldehyde to the corresponding naphthoxazine derivatives.

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28

UCHIKAWA, O., та T. AONO. "ChemInform Abstract: Aminothiazole Derivatives. Part 2. A Facile Synthesis of Condensed 4- Aminothiazole Derivatives Using α-Bromolactams and Thioamides." ChemInform 26, № 24 (2010): no. http://dx.doi.org/10.1002/chin.199524047.

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29

Tilyabaev, Zaitjon, Мukhabbat Khashimova, Vartika Mathur, Rahmat Esanov, Мakhmudjan Gafurov та Kahramon Rustamov. "The licorice (Glycyrrhiza glabra L.) metabolite derivatives as bioinsecticides against Аnacanthotermes turkеstanicus termites". E3S Web of Conferences 434 (2023): 03024. http://dx.doi.org/10.1051/e3sconf/202343403024.

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This article presents the results on the termiticidity of the compounds produced by the reactions of glycyrrhizic acid (GA) with 2-aminothiazole, 3-amino-1,2,4-triazole and 2-aminobenzothiazole. The biological effect of the studied compounds has been found to be dose-dependent. Among the GA derivatives the maximum insecticidal activity has been exhibited by the GA derivative with 2-aminobenzothiazole. Based on the results of the experiments, it has been concluded that the structural-functional approach to the search for biotermiticides is one of the alternative ways to develop environmentally

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30

Rameshwar, M., B. Archana, P. Sachin, T. Vivek, and B. Subhash. "Synthesis, Characterization and Antibacterial Activity of Schiff Base Hybrid from 2-Aminothiazole-pyrazolecarboxaldehyde." Journal of Advanced Chemical Sciences 8, no. 4 (2022): 781–83. http://dx.doi.org/10.30799/jacs.248.22080402.

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The five Schiff bases hybrid have been synthesized from 2-aminothiazole and pyrazole-4-carboxaldehyde under basic condition. The structure of novel compounds were established on the basis of their elemental analyses IR, 1H NMR and 13C NMR, and then screened for their in vitro antimicrobial activity. Among them 3b and 3d showed excellent activity when compared to other derivatives. Other remaining derivatives showed moderate activity.

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31

Filimonov, Aleksandr S., Olga A. Luzina, and Nariman F. Salakhutdinov. "Synthesis of Novel Thiazoles Based on (+)-Usnic Acid." Molbank 2024, no. 4 (2024): M1894. http://dx.doi.org/10.3390/m1894.

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A series of usnic acid derivatives containing a thiazole ring with an amide substituent were synthesized. The convenient method for synthesis of these compounds is a reaction of 14-bromousnic acid with N-acylthioureas. Acylation of aminothiazole does not lead to the targeted compound.

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32

Uchikawa, Osamu, та Tetsuya Aono. "Aminothiazole derivatives.II. A facile synthesis of condensed 4-aminothiazole derivatives using α-bromolactams and thioamides". Journal of Heterocyclic Chemistry 31, № 6 (1994): 1545–51. http://dx.doi.org/10.1002/jhet.5570310645.

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33

Özbek, Oguz, and Meliha Burcu Gürdere. "Synthesis and anticancer properties of 2-aminothiazole derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 196, no. 5 (2021): 444–54. http://dx.doi.org/10.1080/10426507.2020.1871347.

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34

Zhong, Shihua, Zhu Yang, Mingliang Fan, Mu Zhang, and Jianbing Liu. "Progress in the Synthesis of 5-Aminothiazole Derivatives." Chinese Journal of Organic Chemistry 32, no. 2 (2012): 230. http://dx.doi.org/10.6023/cjoc1107041.

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35

Li, Minghua, Yoo-Jin Sim, and Seung-Wook Ham. "Discovery of 2-Aminothiazole Derivatives as Antitumor Agents." Bulletin of the Korean Chemical Society 31, no. 6 (2010): 1463–64. http://dx.doi.org/10.5012/bkcs.2010.31.6.1463.

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36

Wang, Xuemei, Feng Xu, Qingge Xu, et al. "Optimization of 2-aminothiazole derivatives as CCR4 antagonists." Bioorganic & Medicinal Chemistry Letters 16, no. 10 (2006): 2800–2803. http://dx.doi.org/10.1016/j.bmcl.2006.01.126.

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37

Katritzky, Alan R., Xiaojing Wang, and Rexiat Maimait. "Convenient Synthesis of NovelN-Substituted-5-aminothiazole Derivatives." Journal of Organic Chemistry 65, no. 23 (2000): 8077–79. http://dx.doi.org/10.1021/jo000653y.

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38

UCHIKAWA, Osamu, Kohji FUKATSU, Masahiro SUNO, Tetsuya AONO, and Takayuki DOI. "In vivo Biological Activity of Antioxidative Aminothiazole Derivatives." CHEMICAL & PHARMACEUTICAL BULLETIN 44, no. 11 (1996): 2070–77. http://dx.doi.org/10.1248/cpb.44.2070.

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39

Nitin, L. Jadhao. "Synthesis of 2-aminothiazole derivatives : A short review." International Journal of Advance and Applied Research S6, no. 18 (2025): 142–47. https://doi.org/10.5281/zenodo.15254997.

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40

Rezaei, Zahra, Bahador Sarkari, Soghra Khabnadideh, et al. "Synthesis and Biological Activity of Some Aminothiazole Derivatives as Antileishmanial Agents." Anti-Infective Agents 18, no. 2 (2020): 178–89. http://dx.doi.org/10.2174/2211352517666190527112955.

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Background: Leishmaniasis is a major health problem which is caused by the protozoan parasite of the genus Leishmania. Cutaneous leishmaniasis is one type of leishmaniasis and selflimited in most of the cases. However, when the lesions come with scars, they make a deep lifelong stigma. Despite being WHO's research priority, the optimum treatment for this disease has not been found yet. The current study aimed to synthesize and assess the activity of some new aminothiazole compounds against Leishmania major-induced cutaneous leishmaniasis in BALB/c mice. Methods: Eight new aminothiazole derivat

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41

H. Naser, Noor, Monther F. Mahdi, Tagreed N-A Omar, and Amar A. Fadhil. "Synthesis and Preliminary Pharmacological Evaluation of New Analogues of Diclofenac as Potential Anti-inflammatory Agents." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 20, no. 1 (2017): 25–32. http://dx.doi.org/10.31351/vol20iss1pp25-32.

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A group of amine derivatives [4-aminobenzenesulfonamide derivatives, 2-aminopyridine and 2-aminothiazole] incorporated to Î±-carbon of diclofenac a well known non-steroidal anti-inflammatory drug (NSAID) to increase bulkiness were designed and synthesized for evaluation as a potential anti-inflammatory agents with expected COX-2 selectivity. In vivo acute anti-inflammatory activity of the selected final compounds (9, 12 and 13) was evaluated in rats using egg-white induced edema model of inflammation in a dose equivalent to (3 mg/Kg) of diclofenac sodium. All tested compounds produced a signif

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42

Khalifa, Mohamed Ezzat. "Recent Developments and Biological Activities of 2-Aminothiazole Derivatives." Acta Chimica Slovenica 65, no. 1 (2018): 1–22. http://dx.doi.org/10.17344/acsi.2017.3547.

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43

Nikolova, Antonina, Darvin Ivanov, Panayot Bontchev, et al. "Complexes of Ruthenium (III) with Some 2-Aminothiazole Derivatives." Arzneimittelforschung 54, no. 06 (2011): 323–29. http://dx.doi.org/10.1055/s-0031-1296979.

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Han, Shu-Tong, Cong Qi, Zhao-Yuan Zhang, et al. "Synthesis, Characterization, and Anticancer Activity of 2-Aminothiazole Derivatives." Russian Journal of Organic Chemistry 61, no. 5 (2025): 881–91. https://doi.org/10.1134/s1234567825600026.

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Mali, Dhanshri R., Anjali Popat Ghuhe, Nikita Murlidhar Khairnar, and Sakshi Milind Kothawade. "In silico Study, Molecular Docking and Synthesis of 2-Amino thiazole Derivatives using Green Chemistry Approach as Antioxidant Agent." Asian Journal of Organic & Medicinal Chemistry 7, no. 4 (2023): 280–86. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p402.

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A series of novel 2-aminothiazole derivatives were synthesized by microwave assisted method as a green chemistry approach and characterized by spectral techniques and elemental analysis. The antioxidant potential of the derivatives was determined by using molecular docking against two different oxidoreductase protein (PDB: 2CDU and 3NM8). Compounds 3a and 3d show the stronger binding affinity to the target protein. The synthesized drug was pharmacologically evaluated for the antioxidant activity using ascorbic acid as a reference drug, where compound 3a showed the highest inhibition.

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Gao, Dongmei, Lele Shi, Yuhang Huang, Yingmei Lv, Xuan Yang, and Zhenting Du. "Synthesis of 2-Amino-4, 5-Diarylthiazole Derivatives and Evaluation of Their Anti-Candida Albicans Activity." Molecules 30, no. 7 (2025): 1643. https://doi.org/10.3390/molecules30071643.

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The thiazole heterocycle is one of the most common moieties found in various drugs. Using 2-aminothiazole as the core structure, the amino group was functionalized with an amide. As a result, 30 trisubstituted 2-amino-4, 5-diarylthiazole derivatives were synthesized, with different substitutions introduced at the C2, C4, and C5 positions. The anti-Candida albicans biological activities of these synthetic compounds on five kinds of Candida albicans at different concentrations were detected by the microdilution method. In the first round, four derivatives of 2-amino-4, 5-diarylthiazole exhibited

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Hunnur, Raveendra K., Prashant R. Latthe, and Bharati V. Badami. "1,3-Dipolar Cycloaddition Reactions in Heterocyclic Synthesis. Synthesis of [1-[4-(thiazolyl/imidazothiazolyl/triazolyl)phenyl]-1H-pyrazole-3,4-dicarboxylate esters from 3-(4-acetylphenyl)sydnone." Journal of Chemical Research 2005, no. 9 (2005): 592–94. http://dx.doi.org/10.3184/030823405774308907.

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Cycloaddition of 3-(4-acetylphenyl)sydnone (1) with DMAD gave dimethyl 1-(4-acetylphenyl)-1H-pyrazole-3,4-dicarboxylate (2), which on bromination yielded the corresponding monobromoacetyl (3) and dibromoacetyl (4) derivatives. Both compounds 3 and 4 on reaction with thiourea and thioacetamide afforded the 2-amino- (5) and the 2-methyl- (6) thiazole derivatives respectively, while compound 3 on reaction with 2-aminothiazole gave the imidazothiazole 7. Compound 3 was converted into its azide (8), which on 1,3-dipolar cycloaddition with DMAD afforded the 1,2,3-triazole-4,5-dicarboxylate (9).

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Sukdolak, S., N. Vukovic, S. Solujic, M. Milosev, N. Manojlovic, and Lj Krstic. "Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives." Journal of the Serbian Chemical Society 71, no. 6 (2006): 581–85. http://dx.doi.org/10.2298/jsc0606581s.

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Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this synthesis we used thiourea derivatives (2a-j) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 - 45 min. Final products (3a-j) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by ele

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Soni, Arti, Ashwani Kumar, Vivek Kumar, Ravi Rawat, and Volkan Eyupoglu. "Synthesis and Evaluation of Aminothiazole Hybrids as Potential Acetylcholinesterase Inhibitors." Asian Journal of Chemistry 36, no. 5 (2024): 1126–34. http://dx.doi.org/10.14233/ajchem.2024.31241.

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This study aimed to synthesize aminothiazole derivatives with 1,3,4-oxadiazole moiety and evaluated their acetylcholinesterase (AChE) and antioxidant activity in order to check their potency against Alzheimer's disease. Inhibition screening against AChE indicated that synthesized derivatives expressed well to moderate AChE inhibitory activity in vitro. Of the examined synthetic compounds (3a-i), compound 3d expressed the best inhibition with IC50-0.35 µM. The antioxidant activity of all the synthesized compounds was also analyzed by the DPPH assay. Finally, in molecular docking analysis, the b

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Hassan, A. Mohamed, M. El-Medani Samir, and M. Ramadan Ramadan. "Spectroscopic and X-ray crystal structure studies of 2-aminothiazole-3,5- dinitrobenzoic acid and 3,5-dinitrosalicylic acid derivatives." Journal of Indian Chemical Society Vol. 82, Sep 2005 (2005): 799–806. https://doi.org/10.5281/zenodo.5827447.

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Chemistry Department, Faculty of Science, Cairo University, El-Faiyum Branch, El-Faiyum, Egypt <em>E-mail</em> : hamohammed@yahoo.com Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt <em>Manuscript received 6 December 2004, revised 18 April 2005, accepted 21 June 2005</em> Interaction of 2-aminothiazole (AT) base with 3,5-dinitrobenzoic acid (DNB) and 3,5-dinitrosalicylic acid (DNS) gave 1 : 1 molecular species. The salts were investigated using IR, NMR and UV-Vis spectroscopic techniques. Proton transfer occurred from the acid to the hetero nitrogen atom of th

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