Relevant bibliographies by topics / Analogues biomimétiques de nicotinamide

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Analogues biomimétiques de nicotinamide'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Analogues biomimétiques de nicotinamide"

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Lipka, Pawel, Andrzej Zatorski, Kyoichi A. Watanabe, and Krzysztof W. Pankeiwicz. "Synthesis of Methylene-Bridged Analogues of Nicotinamide Riboside, Nicotinamide Mononucleotide and Nicotinamide Adenine Dinucleotide." Nucleosides and Nucleotides 15, no. 1-3 (1996): 149–67. http://dx.doi.org/10.1080/07328319608002377.

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Campbell, P. I., M. I. Abraham, and S. A. Kempson. "Increased cAMP in proximal tubules is acute effect of nicotinamide analogues." American Journal of Physiology-Renal Physiology 257, no. 6 (1989): F1021—F1026. http://dx.doi.org/10.1152/ajprenal.1989.257.6.f1021.

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The possible role of adenosine 3',5'-cyclic monophosphate (cAMP) in the mechanism of the acute inhibitory effects of nicotinamide and analogues on brush-border membrane (BBM) phosphate transport was investigated. Compared with basal values, cAMP content of rat renal proximal tubule suspensions was elevated two- to fivefold when incubated at 37 degrees C for 1 h with nicotinamide, 5-methylnicotinamide, or picolinamide at 1–3 mM and in the presence of a phosphodiesterase inhibitor. Thymidine had no effect on cAMP content. There was significant and specific inhibition of BBM transport of phosphat
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Pankiewicz, K. W., A. Zatorski, and K. A. Watanabe. "NAD-analogues as potential anticancer agents: conformational restrictions as basis for selectivity." Acta Biochimica Polonica 43, no. 1 (1996): 183–93. http://dx.doi.org/10.18388/abp.1996_4552.

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Cofactor type inhibitors (NAD-analogues) of IMP-dehydrogenase (IMPDH) were synthesized and their application as potential anticancer agents are discussed. C-nucleoside isosteres of NAD, C-NAD and C-PAD, showed an effective competitive inhibition of IMPDH, C-NAD but not C-PAD caused extremely potent inhibition of alcohol dehydrogenase. We also synthesized compounds in which nicotinamide riboside was replaced with tiazofurin (TAD-analogues) and the 2' and 3'-positions of adenosine part were fluorinated. The ribose ring of 2'-deoxy-2'-fluoroadenosine is in the C3'-endo conformation whereas 3'-deo
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Pankiewicz, Krzysztof W., Marek M. Kabat, Elzbieta Sochacka, Lech Ciszewski, Joanna Zeidler, and Kyoichi A. Watanabe. "C-Nucleoside Analogues of Nicotinamide Mononucleotide (NMN)." Nucleosides and Nucleotides 7, no. 5-6 (1988): 589–93. http://dx.doi.org/10.1080/07328318808056291.

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Goulioukina, Natasha, Johny Wehbe, Damien Marchand, et al. "Synthesis of Nicotinamide Adenine Dinucleotide (NAD) Analogues with a Sugar Modified Nicotinamide Moiety." Helvetica Chimica Acta 90, no. 7 (2007): 1266–78. http://dx.doi.org/10.1002/hlca.200790127.

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Migaud, Marie, Philip Redpath, Jolanta Haluszczak, and Simon Macdonald. "Nicotinamide Benzimidazolide Dinucleotides, Non-Cyclisable Analogues of NAD+." Synlett 25, no. 16 (2014): 2331–36. http://dx.doi.org/10.1055/s-0034-1379000.

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Hocková, Dana, and Antonín Holý. "Synthesis of Some "Abbreviated" NAD+ Analogues." Collection of Czechoslovak Chemical Communications 62, no. 6 (1997): 948–56. http://dx.doi.org/10.1135/cccc19970948.

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Four new "abbreviated" NAD+ analogues with hydroxymethyl or carboxyl function as a substituent of an aliphatic chain linking the adenine and nicotinamide moieties were prepared using the Zincke reaction as the key step. As intermediates several new acyclic nucleoside analogues containing hydroxy, carboxyl, azido and amino group were prepared.
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Matteucci, Federica, Marta Ferrati, Eleonora Spinozzi, et al. "Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes." Pharmaceuticals 17, no. 6 (2024): 739. http://dx.doi.org/10.3390/ph17060739.

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Nicotinamide adenine dinucleotide (NAD) cofactor metabolism plays a significant role in cancer development. Tumor cells have an increased demand for NAD and ATP to support rapid growth and proliferation. Limiting the amount of available NAD by targeting critical NAD biosynthesis enzymes has emerged as a promising anticancer therapeutic approach. In mammals, the enzyme nicotinamide/nicotinic acid adenylyltransferase (NMNAT) catalyzes a crucial downstream reaction for all known NAD synthesis routes. Novel nicotinamide/nicotinic acid adenine dinucleotide (NAD/NaAD) analogues 1–4, containing a met
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Röllig, Robert, Caroline E. Paul, Magalie Claeys-Bruno, Katia Duquesne, Selin Kara, and Véronique Alphand. "Divorce in the two-component BVMO family: the single oxygenase for enantioselective chemo-enzymatic Baeyer–Villiger oxidations." Organic & Biomolecular Chemistry 19, no. 15 (2021): 3441–50. http://dx.doi.org/10.1039/d1ob00015b.

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Kongmuang, Somlak. "Hydrotropic Solubilization of Riboflavin by Urea, Nicotinamide and Nicotinamide Analogues in Aqueous Systems(การละลายในนํ้าฃองไรโบฟลาวินโดยสารไฮโดรโทรปิค: ยูเ..." Thai Journal of Pharmaceutical Sciences 26, № 1 (2002): 61–68. http://dx.doi.org/10.56808/3027-7922.2288.

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Dissertations / Theses on the topic "Analogues biomimétiques de nicotinamide"

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Röllig, Robert. "Chemical hydride transfer for flavin dependent monooxygenases of two-component systems." Electronic Thesis or Diss., Aix-Marseille, 2021. http://www.theses.fr/2021AIXM0436.

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Le terme monooxygénases flavoprotéiques (flavoprotein monooxygenases FPMO) recouvre aussi bien des flavoenzymes formées d’une seule composante que de deux. L'indépendance fonctionnelle de la partie oxygénase de la 2,5-dicétocamphane 1,2-monooxygénase I (2,5-DKCMO), une Baeyer-Villiger monooxygénase de type II, FMN dépendante, de sa contrepartie réductase, ainsi que le mécanisme de transfert de la flavine par libre diffusion, ont été étudiés dans des réactions sans réductase mais où des analogues biomimétiques synthétiques de nicotinamide (NCB) ont été utilisés pour réduire le FMN. L'équilibre
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McGranaghan, Andrea. "Synthesis and evaluation of carbocyclic nicotinamide cofactor analogues." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30007.

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The history of the discovery and structure elucidation of many important nucleotides and coenzymes is reviewed in chapter 1. Some recent developments in nucleotide chemistry are also discussed including the discovery and biological importance of cyclic ADP ribose and carbocyclic nucleosides such as Aristeromycin and Neplanocin A. In chapter 2, the preparation of a carbocyclic analogue of NAD+ (figure 1) is reported. This analogue is synthesised both as a mixture of diastereoisomers which are separated by HPLC and as a single diastereoisomer via the homochiral synthesis. (Fig. 8742). In chapter
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Blondiaux, Nicolas. "Nouvelles approches thérapeutiques par potentialisation d’antituberculeux analogues du nicotinamide." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S049/document.

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Les antibiotiques représentent à l’heure actuelle le seul moyen de lutte efficace contre la tuberculose. Parmi eux, l’éthionamide (ETH) est l’un des antituberculeux les plus efficaces. Il pose cependant des problèmes d’effets indésirables non négligeables ce qui relègue son utilisation en seconde ligne de traitement. Ces inconvénients aboutissent fréquemment à une inobservance au traitement, à l’origine du développement de souches résistantes.L’ETH, à l’instar d’autres composés antimycobactériens, est une pro-drogue nécessitant son activation métabolique par une enzyme produite par la mycobact
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Losset, Denis. "Réductions biomimétiques chimio et énantiosélectives par des réactifs immobilisés sur des polymères organiques ou minéraux." Rouen, 1990. http://www.theses.fr/1990ROUE5016.

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Le greffage de réactifs modèles du NADH, dérivés de la structure dihydro-1,4 pyridinique porteurs d'une copule chirale issue de l'amino-2 butanol a été réalisé sur polystyrène chorométhylé. Avec le modèle le moins encombré, nous avons obtenu la même réactivité qu'avec le modèle libre. Nous réalisons le greffage sur silice de réactifs modèles dérivés de la structure thiéno[2,3-b] dihydro-1,4 pyridine. Ces modèles possèdent une bonne réactivité et sont régénérables. L'immobilisation d'un réactif porteur d'une copule chirale a permis de réaliser la réduction asymétrique d'un substrat prochiral av
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Fougère, Cécile. "Nouvelle méthode de synthèse de dérivés phosphiniques : Application à la synthèse de nouveaux biomimétiques dérivés de peptide et de PNA." Paris 13, 2009. http://www.theses.fr/2009PA132017.

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L’utilisation de peptides et d’oligonucléotides comme médicaments est une nouvelle approche plus sélective pour le traitement de nombreuses pathologies. Cependant cette nouvelle stratégie se heurte aux problèmes de stabilité de ces macromolécules dans les milieux biologiques. Une solution peut être d’utiliser des mimétiques de peptide et d’oligonucléotides dont les propriétés permettront de pallier ces problèmes. Dans ce travail nous nous sommes intéressés au développement de mimes oligonucléotidiques : les acides peptidiques nucléiques (PNA), ainsi qu’à des mimes de peptides. Nous avons chois
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Book chapters on the topic "Analogues biomimétiques de nicotinamide"

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O’Nuallain, Eoin M., and Stephen G. Mayhew. "Studies on the reactions of flavin- and nicotinamide nucleotide analogues with a bacterial electron-transferring flavoprotein." In Flavins and Flavoproteins 1987, edited by D. E. Edmondson and D. B. McCormick. De Gruyter, 1987. http://dx.doi.org/10.1515/9783110884715-063.

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Conference papers on the topic "Analogues biomimétiques de nicotinamide"

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Tarasenko, Yuliya, Tatyana Abramova, Vladimir Silnikov, Dmitri Filippov, Nico Meeuwenoord, and Gijs Van Der Marel. "Synthesis of DNA and RNA oligonucleotides containing riboflavin and nicotinamide ribonucleoside analogues." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414383.

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Journal articles
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