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Dissertations / Theses on the topic 'And anticancer activities'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lee, C. C. "Anticancer activities of some medicinal plants from Malaysia and Thailand." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408285.

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2

Chou, Wen-Chien. "Arsenic's anticancer activities and its effects on global gene expression." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080641.

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3

Luhavaya, Hanna. "Biosynthesis of salinomycin, a polyether ionophore with anticancer and antituberculosis activities." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709266.

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4

Xiao, Zhe. "Biosynthetic studies of tetrodotoxin and its anticancer activities assessment in vitro." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/56.

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In this study, the synthesis of TTX by three species of TTX-producing bacteria (Vibrio alginolyticus, Microbacterium arabinogalactanolyticum and Serratia marcescens) was conducted in a 10-L fermentor under the same controlled fermentation conditions for each of a period of 60 hours. The bacterial growth curves were monitored and the TTX synthesized in the culture medium was determined by HPLC. The TTX biosynthesis was found limited at the microgram level per L of culture medium with toxicities 14.7 MU (mouse unit) and 13.0 MU per mL in the partially purified culture medium of V. alginolyticus

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5

Zhang, Huiying. "Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335.

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6

Liu, Yi. "Inhibitors of Basal Glucose Transport and Their Anticancer Activities and Mechanism." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1336573884.

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7

Sutharson, L. "Evaluation of anti-inflammatory and anticancer activities of some plants of sub-himalayan region of Sikkim." Thesis, University of North Bengal, 2007. http://hdl.handle.net/123456789/935.

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8

Siriwatanametanon, Nisarat. "Traditionally used Thai medicinal plants : in vitro anti-inflammatory, anticancer and antioxidant activities." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522827.

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9

Ngungeni, Yonela. "Antimicrobial, anticancer and catalytic activities of green synthesized Avocado seed extract-gold nanoparticles." University of the Western Cape, 2019. http://hdl.handle.net/11394/7809.

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>Magister Scientiae - MSc<br>Nature through billions of years of trial and error has produced an immeasurable amount of natural systems like plants, birds and animals. The intelligence of nature is hidden in these natural systems and researchers are turning towards “Nature’s intelligence” to find inspiration and advance novelty in the development of nanomaterials. Gold nanoparticles (AuNPs) have unique optical, electronic and physicochemical features which has gained them popularity and widespread exploitation in various applications. The conventional methods used for AuNPs synthesis emp

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10

Wen, Zhiwei. "Azido- and Triazolyl-modified Nucleoside/tide Analogues: Chemistry, Fluorescent Properties, and Anticancer Activities." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3789.

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Two classes of C5 azido-modified pyrimidine nucleosides were synthesized and explored as radiosensitizers. The 5-azidomethyl-2'-deoxyuridine (AmdU) was prepared from thymidine and converted to its cytosine counterpart (AmdC). The 5-(1-azidovinyl) modified 2'-deoxyuridine (AvdU) and 2'-deoxycytidine (AvdC) were prepared employing regioselective Ag-catalyzed hydroazidation of 5-ethynyl pyrimidine substrates with TMSN3. AmdU and AmdC were converted to 5'-triphosphates AmdUTP and AmdCTP, and incorporated into DNA-fragments via polymerase-catalyzed reaction during DNA replication and base excision

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11

Ye, Weiping. "Mechanisms of anticancer activities of (-)-gossypol-enriched cottonseed oil against human breast cancer cells." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174672705.

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12

Prasad, Asharani. "Synthesis and Antioxidant, Anticancer, and Antimicrobial Activities of Palmityl Ester Derivative of Carnosic Acid." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/27011.

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Carnosic acid (CA) along with carnosol (CAR) is the strongest phenolic diterpene antioxidants (PDAs) present in rosemary plant. However, CA has low antioxidant activity in emulsion-type food system due to its polar nature. The identification and characterization of the anticancer and antimicrobial properties of natural products and their semisynthetic derivative such as that of CA and CAR have received significant interest over the years. The goals of this research were to synthesize lipophilic palmityl derivative (PE) of CA and study its antioxidant activity in bulk and emulsified corn oil. A

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13

Shum, Yuen-ting. "Functionalized platinum (II) and gold (I) acetylide complexes structural and spectroscopic properties and anticancer activities /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38639865.

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14

Freidberg, Ryno. "An investigation into the antimicrobial and anticancer activities of Geranium incanum, Artemisia afra and Artemisia absinthium." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1045.

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It has been estimated that between 3000 and 4000 plant species are used for their medicinal properties throughout South Africa, with approximately 27 million South Africans making use of traditional medicines. Of this 27 million, 3 million South Africans rely on traditional medicine as their primary source of health care. Of the 250 000 to 500 000 known plant species, very few have been investigated for their pharmacological qualities, and compounds of significant medicinal value may still remain undiscovered in many plant species. The aims of this study included investigating the antimicrobia

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15

Alves, Avelar Leandro Antonio [Verfasser]. "Design and Synthesis of Histone Deacetylase Inhibitors with Antiplasmodial and Anticancer Activities / Leandro Antonio Alves Avelar." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1161941509/34.

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16

Kamatou, GPP, Zyl RL Van, H. Davids, Heerden FR Van, ACU Lourens, and AM Viljoen. "Antimalarial and anticancer activities of selected South African Salvia species and isolated compounds from S. radula." Elsevier, 2007. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000518.

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Extracts of seventeen Salvia species used in traditional medicine in South Africa were subjected to biological testing. The potential ability to inhibit the in vitro growth/proliferation of Plasmodium falciparum (FCR-3 strain) and the cytotoxic effects on three human cancer cells [breast adenocarcinoma (MCF-7), colon adenocarcinoma (HT-29) and glioblastoma (SF-268)] and a human kidney epithelial cell line were investigated. The extracts displayed antimalarial activity with IC50 values ranging from 3.91 to 26.01 μg/ml and S. radula displaying the most favorable activity. Two compounds were subs

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17

Khurshid, Chrow Ahmed. "Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities." Thesis, University of Salford, 2017. http://usir.salford.ac.uk/43742/.

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Considerable excitement has been generated by the discovery of active compounds from marine organisms. These compounds have a remarkable role in cancer treatment, with fewer side effects on general health. Sulphated glycosaminoglycan (GAGs) are present in all animals, vertebrate and invertebrate. They are of proven economic importance, not only in the food industry but also in the pharmaceutical field. The present study identifies the key structural differences between the GAGs isolated from whelk and mammalian GAG and investigates their biological activity in relation to cancer and malaria. G

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Van, Huyssteen Mea. "Collaborative research with traditional African health practitioners of the Nelson Mandela Metropole : antimicrobial, anticancer and anti-diabetic activities of five medicinal plants." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/663.

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The promotion and development of indigenous knowledge pertaining to the traditional African healing system is one of the prime objectives set out by the South African government. Despite excellent research opportunities and funding, the biggest problem with ethnopharmacological research is a lack of interaction with indigenous communities, which tends to dilute the benefits this research has to offer these communities. The primary aim of this study was thus to promote the traditional African healing system through collaborative medicinal plant research with local traditional health practitione

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19

Muniz, Carvalho Edinilton. "Metallo-drugs as nitric oxide (NO•) and/or nitroxyl(HNO) donors : development of new agents and investigation of anticancer, antihypertensive and antituberculosis activities." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30217.

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Le cancer, les maladies cardiovasculaires et la tuberculose (TB) sont des défis de santé majeurs pour lesquels diverses stratégies médicamenteuses ont été développées, y compris l'utilisation d'agents inorganiques tels que des complexes métalliques et l'oxyde nitrique (NO•) ou le nitroxyle (HNO). L'objectif de la thèse porte sur la conception, la synthèse, les études physico-chimiques et l'évaluation biologique de molécules à base de métaux capables de libérer NO• et/ou HNO avec des effets pharmacologiques. Deux types de plates-formes organiques sont envisagés comme ligands des complexes de fe

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20

Takaidza, Samkeliso. "Phytochemical analysis and biological activities of crude extracts from selected Tulbaghia species." Thesis, Vaal University of Technology, 2018. http://hdl.handle.net/10352/434.

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PhD (Department of Biotechnology, Faculty of Applied and Computer Sciences), Vaal Universtiy of Technology<br>The genus Tulbaghia has been used in traditional medicine to treat various ailments such as fever, earache, tuberculosis and esophageal cancer. However, there is limited scientific evidence to support its use. Therefore the objectives of this study were to perform phytochemical analysis, investigate the antioxidant, antimicrobial, anticancer, immunomodulatory activities and toxicity of crude acetone and water extracts from selected Tulbaghia species. Standard methods were used for pr

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21

Da, Silva Pierre. "Une histoire de la recherche de substances naturelles à activités thérapeutiques." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-01038036.

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L'identification d'une substance naturelle, produite par un organisme vivant n'est que l'une des toutes premières étapes du développement d'un nouveau médicament. Beaucoup de molécules à visée thérapeutique développées par des sociétés pharmaceutiques ont en fait été découvertes dans des laboratoires académiques. C'est toujours un continuum de la recherche fondamentale vers la recherche appliquée, souvent de la recherche publique vers la recherche privée, qui aboutit à la mise au point d'un médicament. Leur fabrication, directement à partir de substances naturelles, pose fréquemment le problèm

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22

Joseph-Angélique, Josianny. "Contribution a la connaissance chimique et valorisation biologique de nectandra membranacea (swartz) grisebach de Guadeloupe." Thesis, Antilles, 2015. http://www.theses.fr/2015ANTI0006/document.

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Nectandra membranacea (Lauraceae) est une plante très commune aux Petites Antilles. Aucune utilisation traditionnelle de cette plante n’est connue mais le genre Nectandra, qui représente le deuxième plus important de la famille des Lauraceae avec 114 espèces reconnues, présente des propriétés analgésiques, anti-inflammatoires et énergétiques (Le Quesne et al 1980). Nectandra a également démontré une activité antitumorale (Silva-Filho, 2004). Les nombreuses propriétés du genre et le peu de connaissance chimique sur cette espèce nous ont incités à réaliser une étude phytochimique et à évaluer le

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23

Ben, Rahal Neïla. "Extraction, identification et caractérisation des molécules bioactives de la graine et de l'huile de Silybum marianum. Étude de leurs activités antioxydante et antitumorale." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0137/document.

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L'extraction par CO2 supercritique démontre les avantages d'un procédé de chimie verte en comparant ce procédé à la méthode d'extraction par solvant organiques et en tenant compte du degré de toxicité et de pollution du solvant. L'extraction par solvants organiques met en évidence l'influence du solvant d'extraction alors que l'extraction par CO2-SC met en évidence l'influence de différents paramètres dont la pression, la température, le temps de contact entre la matrice végétale et le CO2-SC, le diamètre moyen des particules et l'ajout d'un co-solvant. L'analyse chromatographique a permis d'i

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Yang, Pei-Yu, and 楊佩玉. "Mechanisms of Anticancer Activities of Norcantharidin." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/96090225874357380512.

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博士<br>高雄醫學大學<br>天然藥物研究所<br>98<br>Cancer is a major health problem in the world. One in four deaths in American is due to cancer. Cancer is the first among the top ten leading causes of death in Taiwan. Natural products provide an abounding source for developing new drugs with anti-cancer activities. Cantharidin, a bioactive compound, purified from mylabris, and has been used as a traditional Chinese remedy to eliminate swelling for over 2000 years. Although cantharidin has anti-tumor properties, it causes leukocytosis and severe side effects in the urinary system. Norcantharidin, the demethyla

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25

Lu, Kuei Ju, and 盧桂汝. "Detection of anticancer activities of Typhonium divaricatum and investigation of its anticancer mechanism." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/46203797059980027591.

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碩士<br>義守大學<br>生物技術與化學工程研究所碩士班<br>95<br>In Taiwan, Typhonium divaricatum (L.) Decne is a folk medicine herb endowing with reducing ecchymosis, hemostasis, detumescence, detoxication, anticancer, and so on. However, these bioactivities have not yet been examined scientifically. This study investigated the anticancer activities of T. divaricatum and its mechanisms. Fresh leaves of T. divaricatum were extracted with ethanol and then fractionated by n-hexane, ethyl acetate (EA) and methanol. In antioxidant activity assay, EA fraction showed a good DPPH radical scavenging activity (EC50 = 89.59 ± 0.

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Chen, Yueh-Ying, and 陳悅穎. "An Investigation on the Anticancer Activities of Ginsenoside Rh2." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/57326795634589976149.

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碩士<br>國立成功大學<br>藥理學研究所<br>91<br>The anticancer activity of a pure ginsenoside from Panax ginseng C.A. Meyer, G-Rh2, was investigated. We first tested the cytotoxicities of G-Rh2 and a mixture format termed “Sabonin” that contains 1% G-Rh2 and other herbal ingredients on a variety of cancer cell lines. Sabonin exhibits a dose-dependent growth inhibitions on NIH3T3/ras and SW 480 cells. G-Rh2 exhibits a dose-dependent growth inhibitions of A549, NIH3T3/ras and B16F10 cells. However, the same dose has little effect on NIH3T3 wild-type and PC-3 cells, suggesting discriminatory inhibitions of ginse

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Zhang, Lin. "Biological activities and structural characterisation of anticancer herbal polysaccharides." Thesis, 2017. http://hdl.handle.net/1959.7/uws:45024.

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In recent years, medicinal plants have become popular for the treatment of several diseases due to their efficacy and cost effectiveness. Plant derived therapeutic agents are increasingly sought out as pharmaceuticals for the treatment of life-threatening illnesses. Important contributions have already been made in the recent years to the drug market by the compounds isolated from natural sources or from their derivatives. There is no doubt that, novel lifesaving drugs could be discovered by a systematic evaluation of ethno medicinal information using modern scientific tools. This thesis atte

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Chou, Jui-Yi, and 周瑞益. "Determination of anticancer activities of several chemical synthetic compounds and investigation of GO-13 mediated anticancer mechanism." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/09597763098929567357.

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碩士<br>國立臺灣大學<br>藥學研究所<br>90<br>Cancer is one of the serious problems in many countries. In the recent years, it has been the most important causative factor causing deaths in Taiwan. Lung cancer is one of the predominant leading causes in human cancer death, accounting for the lives of more than a million people yearly worldwide. Therefore, several strategies for the clinical therapies have been raised. For the treatment of solid tumors, the chemotherapies, such as the apoptotic and antiangiogenetic agents or the combination of both are developed. In the present work, we examined the synthetic

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Huang, Chin Jung, and 黃靖容. "Antioxidant and anticancer activities of aqueous extracts from Toona sinensis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/03993873343901730757.

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碩士<br>中國醫藥大學<br>營養研究所<br>93<br>英文總摘要 Toona sinensis Roem belongs to the family Meliacceae.The leaves and young shoots are used as vegetable in Chin.In fact,the trees are also widely used medically.Previous phytochemical work on Toona sinensis had led to the isolation phenolic compounds. To further search for the novel bioactive agents from Meliaceae plants, Toona sinensis was chosen for phytochemical investigation and known compounds including, gallic acid, methyl gallate, kaempferol, quercitin, quercitrin, rutin and catechin, were isolated and identified from this plant. In this stu

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Sun, Nai-Yun, and 孫乃云. "Study of Gelidium water extracts on antioxidant and anticancer activities." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/14656996261582682294.

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碩士<br>國立臺灣海洋大學<br>水產養殖學系<br>94<br>The aim of this study was to compare the difference in antioxidant ability and anticancer activity between Gelidium species, and also to check the effects of post-harvesting process in respect to the effective compositions. The Gelidium species used in this work are Pterocladiella capillacea, Gelidium amansii, and Gelidium japonicum, in which they are lyophilized immediately, or subjected to oven drying at 80℃, or half-sun-dry plus washing. The antioxidant activities (DPPH and ABTS), total phenolic compounds and flavonoid content, MAA (mycosporine-like amino a

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Lopes, Elizabeth de Abreu. "Spirooxadiazoline oxindoles: synthesis and evaluation of anticancer and antimalarial activities." Master's thesis, 2017. http://hdl.handle.net/10362/24089.

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Cancer is one of the modern world’s most common and deadly non-infectious disease. According to WHO Cancer Report of 2015, it is one of leading causes of morbidity and mortality worldwide with 8.8 million deaths in 2015 and it is expected to rise about 70% over the next 20 years. The non-selectivity and acute toxicity of many anticancer agents has prompted the search for new alternatives with improved tumour selectivity, efficiency and safety. Spirooxindole alkaloids are a family of natural products that have a spiro ring fusion at position 3 of the oxindole core. Several natural products tha

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Gowda, Krishne G. "Anticancer and antibacterial activities of acridones and circumvention of drug resistance." Thesis, 2000. http://hdl.handle.net/2009/2235.

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Yang, Po-Wen, and 楊博文. "The anticancer activities of a local variety of Ipomoea batatas Lam." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/57111079425451614166.

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碩士<br>國立成功大學<br>藥理學研究所<br>93<br>Many anticancer drugs are derived from nature, such as taxol and camptothecin. A specific variety of Ipomoea batatas Lam obtained from local market is tested for its anticancer activity. The leaves were extracted with methanol and then partitioned with water and ethyl acetate. The ethyl acetate extract （IB-EAE）is found to exert significant cytotoxicity against several cancer cell lines tested in vitro in a dose-dependent manner. The anticancer activity of IB-EAE was investigated further in vivo using mouse bearing transplanted tumor cells. IB-EAE significantly i

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Lin, Jiong-Cheng, and 林炯丞. "The Molecular Mechanism of Anticancer Activities of Curcuma Longa Essential Oils." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/56829607766741219425.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>102<br>Cancer is the leading cause of death among people. The brain cancer, though not one of the prevalent diseases, is worth of investigation because of its high death rate. Curcuma (Curcuma) is a perennially herbal turmeric. Many papers have pointed out that turmeric plant has anti-inflammatory, reducing the biological activity of blood glucose, liver protection, anti-oxidation, anti-microbial and anti-virus activities. We applied the essential oils TCLR-1, extracted from the local turmeric plant, to human brain cancer cell lines to explore and elucidate the m

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Yi, Weiguang. "Evaluation of anticancer activities of phenolic compounds in blueberries and muscadine grapes." 2005. http://purl.galileo.usg.edu/uga%5Fetd/yi%5Fweiguang%5F200512%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2005.<br>Directed by Casimir C. Akoh. Includes articles published in Journal of agricultural and food chemistry, and articles submitted to Food research international and Journal of agricultural food chemistry. Includes bibliographical references.

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Chien, Chiao-Yun, and 簡皎芸. "Further characterization of anticancer activities from a local variety of Canavalia gladiata." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/33617941313124935042.

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碩士<br>國立成功大學<br>藥理學研究所<br>92<br>Our lab had previous shown that cold water extract from a local variety of Canavalia gladiata, termed IC-1, possessed some interesting anticancer activities. In this investigation, I clarify and identify further the anticancer activities of IC-1. IC-1 shows in vitro cytotoxicities toward some cancer cell lines in a dose-dependent manner. Flow cytometry assay reveals that cancer cells death is due to apoptosis, which is supported by two more assays—DNA fragmentation and Hoechst 33258 nucleus staining. Gelatin zymography of matrix metalloproteinase 2 and 9, the tw

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Oliveira, Daniela dos Santos. "Antigenotoxic and anticancer activities of plant extracts using different eukaryotic cell models." Master's thesis, 2017. http://hdl.handle.net/1822/45752.

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Dissertação de mestrado Biologia Molecular, Biotecnologia e Bioempreendedorismo em Plantas<br>In the last decades, the interest in medicinal plants has increased significantly owing to the antioxidant properties found in their natural extracts, which are responsible for many therapeutic effects. Therefore, there has been a great demand in discovering novel compounds, in order to develop new products (e.g. pharmaceuticals, cosmetics and dietary) characterized by high efficiency and low toxicity. Genotoxic stress might be induced by external and internal factors, causing serious damage since

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Ling, Shu-Li, and 林豎禮. "The Investigation of Molecular Mechanism and Anticancer Activities of Ginsenosides Mixture PBD-1226." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/07205602415584348588.

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碩士<br>國立中興大學<br>生物化學研究所<br>101<br>The root of Panax Ginseng is often used as a folk medicine. Recently, it has been reported that its main active ingredient, Ginsenosides, which are digested in gastro-intestinal tract, can be used as an anti-cancer therapies. ginsenosides mixture PBD- 1226, a mixture of appD (16 %), aPPT (33 %), and Rh2 (51 %), was used to have the cancer cell growth inhibition in several cancer cell lines according to our MTT assay results. Although many single ginsenosides are reported to have an anti-cancer activity, less investigation is aimed at the effect of combination

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Chu, Hung Lun, and 祝宏倫. "Design and Characterization of short Antimicrobial Peptides with Anticancer and Anti-endotoxin activities." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/hmaj24.

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Chen, Tai-Lin, and 陳泰霖. "Synthesis and Anticancer Activities 6-Fluoro-2-(3-fluorophenyl)-4-substituted anilinoquinazoline Derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/16409339876340679627.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>In exploring the potential anticancer drugs, DNA is considered the target for drug design. Using the molecular modeling, the interactions of DNA with target compounds were discussed and evaluated in different parameters, such as the binding energy and the docking scores. By the reasons, 6-fluoro-2-(3-fluorophenyl)-4-substituted anilinoquinazoline analogs were designed and synthesized as DNA intercalating agents. The y were assayed for their cytotoxicity in vitro against a panel of seven cancer cell lines including human leukemia (HL-60), human leukemic monocyte

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Liao, Chih-Ching, and 廖智菁. "An Investigation on the Anticancer Activities of Azatyrosine Analogues─the HPW 98 Series." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/44039214611622957843.

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碩士<br>國立成功大學<br>藥理學研究所<br>89<br>Azatyrosine [L-b-(5-hydroxypyrid-2-yl)-alanine], a chemical isolated from Streptomyces chilanesis, has been reported to inhibit the growth of c-Ha-ras-, c-raf- and c-erb-2-transformed NIH3T3 cells. The chemical also inhibits 7,12-dimentyl-benz [a]- anthracene-induced carcinogenesis in mice. A series of azatyrsoine analogues, modified to be more lipophilic, were tested for their anticancer activities. The analogues, termed the HPW 98 series, exhibit IC50 values lower than that of azatyrosine in magnitudes of 104 to 105, affecting cell cycle and inducing apoptosis

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Chen, Shu-Ju, and 陳淑茹. "Studies on the antihypertension and anticancer activities of Graptopetalum paraguayense E. Walther extracts." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/84243569934137636508.

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博士<br>靜宜大學<br>食品營養研究所<br>95<br>Three studies were comprised in this dissertation. First, the antihypertension and antioxidant activities of Graptopetalum paraguayense E. Walther (GP) extracts were be studied. The kinetic properties and capacities of the GP extracts to inhibit angiotensin converting enzyme (ACE) were evaluated. The results showed that GP extracts showed potent inhibitory effects on ACE, and the inhibitory action of the extracts may resulted from chelating zinc cofactor which was necessary for ACE activity. The inhibition kinetics, analyzed by Lineweaver-Burk plot, revealed t

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Ying, Tsai-Pei, and 蔡珮瀅. "An Investigation on the General Anticancer Activities of Phellinus linteusActivities of Phellinus linteus." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/27670513888484162754.

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碩士<br>南台科技大學<br>生物科技系<br>96<br>Abstract Phellinus linteus belongs to the family of Hymenochaetaceae founded on wild mulberry trees. It’s extremely rare to find in the nature and hardly to cultivate artificially. The P. linteus was used as a medicine in Korea and Japan, due to its highly effective in treatment for anti-tumor, diuresis, gastro-intestinal disorders, and breathing disorders. We have successfully cultivated the P. linteus CCJ PL-101 and investigated the anti-tumor activities by in vitro and in vivo assay. The extracts of P. linteus were following by hot water, ethanol, methanol, et

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Wang, Ching-Min, and 王靜敏. "An Investigation on the Anticancer Activities of Azatyrosine Anlogues-the HPW 99 series." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/jkxyfj.

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碩士<br>國立成功大學<br>藥理學研究所<br>90<br>bstract Azatyrosine [L- β-(5-hydroxypyrid-2-yl)-alanine], an antibiotic agent isolated from Streptomyces chibanesis, is tyrosine analogue in which a pyridine group replaces the benzene group. The chemical has been reported to inhibit 7, 12-dimethyl-benz [a]-anthracence-induced carcinogenesis in mice. However, to exert its cytotoxicity, azatyrosine should be used at a fairly high concentration. The HPW 99- series are synthetic analogues of azatyrosine designed to be more lipophic for easier entry into the cells. One analogue, HPW 99-5, exhibits IC50 values lower

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Wang, Kuo-Chang, and 王國全. "An Investigation on the General Anticancer Activities of a local variety of Canavailia galadiata." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/37240879699993833247.

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碩士<br>國立成功大學<br>藥理學研究所<br>91<br>An ammonium sulfate fractioned and water soluble crude extract from a local variety of Canavailia galadiata was tested for its general anticancer activity. In vitro tests showed that the extract is toxic to some cancer cell lines in a dose-dependent manner; the toxicities, however, disappeared when the extract was heated, suggesting that the toxic principle is a protein. Cell flow cytometry study suggested that cancer cell death is due to apoptosis. In drug combination studies the extract enhanced the cytotoxicities elicited by some currently commonly used cance

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Mohammed, Hamdoon [Verfasser]. "Natural and synthetic flavonoid derivatives with potential antioxidant and anticancer activities / von Hamdoon Mohammed." 2009. http://d-nb.info/999319167/34.

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Lee, Pei-Chih, and 李培志. "Anticancer activities of 3a-aza-cyclopenta[a]indenes derivative, a novel bifunctional alkylating agent." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/48424511265291485343.

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博士<br>國立陽明大學<br>藥理學研究所<br>98<br>BO-1012, a synthetic derivative of 3a-aza-cyclopenta[a]inden, is a novel bifunctional alkylating agent that induces a significant amount of DNA interstrand crosslinks and has been shown to have a potent anticancer activity. Since drug resistance is still a crucial factor leading to failure of cancer chemotherapy, the effect of combining bifunctional alkylating agents and arsenic trioxide (ATO) was explored in this study to suppress the growth of tumor cells with inherited or acquired resistance to therapeutic agents. In cultured cells, combining of ATO and BO-10

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Tsai, Yi-Ling, and 蔡宜伶. "Study on the heat shock protein 90-inhibitory effect and anticancer activities of withanolides." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/88885257374670145529.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>99<br>Natural compounds from plants have been an important source for the discovery of anticancer drugs. It is known that withanolides, a group of steroidal lactones found in Solanaceae plants, exhibit anti-tumor, anti-angiogenic, anti-invasive, and chemo-preventive activities. In a previous study, we have demonstrated that a withanolide, tubocapsenolide A (TA), induced cycle arrest and apoptosis in human breast cancer MDA-MB-231 cells which was associated with the inhibition of heat shock protein 90 (hsp90). In order to confirm whether hsp90 inhibition is a general

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Wei, Pei-Hsuan, and 魏培萱. "Study on Anticancer and Anti-Inflammatory Activities of Herbal Ethanol Extracts from Cuscuta spp." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/54946439747466254496.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>99<br>This study aims to investigate the efficacy of extracts of Cuscuta spp. parasitizing on different hosts on human hepatoma HepG2 and Huh7, and LPS (Lipopolysaccharide)-stimulated mouse macrophage RAW264.7 cell lines. The authenticity of Cuscuta species was identified through comparison of sequences from the internal transcribed spacers of rDNA. The chemical profiles of extracts were illucidated by high pressure liquid chromatography where hyperin was used as the standard reference. Moreover, the total flavonoids of extracts were measured, and the relationship be

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Wang, Chun Chieh, and 王俊傑. "Studies on the Chemical Constituents and Anticancer Activities of Camellias Against PC3 Prostate Cancer Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/06111464447681668457.

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博士<br>大葉大學<br>生物產業科技學系<br>103<br>Most studies of tea trees have focused on its ornamental properties, there are fewer published studies on their medical values. The purpose of this study was to compare the chemical constituents and the biological potential of the water extract of leaves in nine species of Camellia including C. sinensis. Our results indicated that C. sasanqua showed potent anticancer activities in prostate cancer PC3 cells. In addition to catechins, the major component, eugenyl beta-primeveroside was detected in C. sasanqua. Eugenyl beta-primeveroside blocked the progression of

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