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Dissertations / Theses on the topic 'Anhedonic depression'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Benitez, Andreana. "Executive Functioning Abilities are Differentially Associated with Anhedonic Depression and Anxious Arousal." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1276455545.

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2

Martis, Lena-Sophie. "Translational assessment of cognitive impairments in depression models." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33234.

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Major depressive disorder (MDD) affects 300 million people worldwide and is a major contributor to the global burden of disease. The aetiology of depression, emerging through a gene x environment interaction, is still incompletely understood which prevents tailoring of treatment approaches. In addition to MDD core symptoms, such as anhedonia (a diminished anticipation or experience of pleasure), depressed patients suffer from a plethora of manifestations including cognitive impairments, which occur primarily in the domains of executive function, attention and memory. Patients remitted from aff

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3

Kalmbach, David A. "SPECIFICITY OF ANHEDONIC DEPRESSION AND ANXIOUS AROUSAL WITH SEXUAL PROBLEMS, AND THE VALIDATION OF SEXUAL FUNCTIONING MEASURES AMONG HEALTHY MALES AND FEMALES." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1308590687.

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4

Pitt, Joanna Diana (Jodi). "Mind wandering and anhedonia : a systematic review ; An experience sampling study : does mind wandering mediate the link between depression and anhedonia?" Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/23430.

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Background: There is increasing theoretical interest in the idea that a greater tendency for the mind to wander may reduce positive emotion experience, with specific interest in clinical conditions such as depression that are characterised by reduced pleasure experience (anhedonia). However, it is unclear to what degree these claims are empirically supported. Objective: A systematic review was conducted to examine the evidence regarding the association between mind wandering and positive emotion experience. Method: The Cochrane library, MEDLINE, PsycINFO, and Web of Knowledge databases were se

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5

Jell, Grace Elizabeth. "Understanding anhedonia : investigating the role of mind wandering in positive emotional disturbances." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/27942.

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Depression is a highly debilitating illness for which there is currently sub-optimal treatment outcomes. Anhedonia (a loss of interest and pleasure) is a core symptom of depression that predicts poorer illness course and is currently not well repaired in psychological treatments. Acute and relapse prevention outcomes may be improved by clarifying which psychological mechanisms cause and maintain anhedonia, so that mechanisms can be systematically targeted in therapy. Mind wandering (a shift in contents of thoughts away from an ongoing task and/or events in the external environment to self-gene

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6

Brauner, N. "Content-free cueing as a technique to inhibit mind wandering and treat anhedonia in depression." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1409970/.

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This thesis addresses the relationship between mind wandering and mood. Mind wandering is defined as a state of ‘decoupled attention’ removed from the immediate contexts towards unrelated thoughts and feelings (Smallwood & Schooler, 2006). Part one is a literature review that investigates the association between mind wandering and mood. It examines whether mind wandering affects mood and vice versa, and how mind wandering relates to mood disorder. Overall the findings were inconsistent. Gaps in the literature are highlighted and suggestions for future research are discussed. Part two consists

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7

Thomaz, Cassia Roberta da Cunha. "Possíveis inter-relações entre a submissão ao Chronic Mild Stree(CMS) e o desempenho operante." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/47/47132/tde-26112009-135126/.

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Chronic Mild Stress (CMS) é um modelo animal de depressão no qual ratos são submetidos a um protocolo de estressores moderados de forma crônica. Em função disso, o consumo e preferência por água com sacarose diminuem. Tal redução costuma ser considerada uma medida de anedonia, sintoma central da depressão em humanos. Três estudos realizados no Laboratório do Programa de Estudos Pós- Graduados em Psicologia Experimental da PUC-SP demonstraram que esse efeito é atenuado pela exposição a uma condição operante em esquema concorrente FR água FR sacarose. O presente estudo teve por objetivo investi

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8

Szebeni, Attila, Katalin Szebeni, Timothy P. DiPeri, et al. "Elevated DNA Oxidation and DNA Repair Enzyme Expression in Brain White Matter in Major Depressive Disorder." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/943.

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Background: Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood. Methods:Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured in Brodmann area 10 (BA10) and/or amygdala (uncinate fasciculus) white matter tissue from brains of MDD (n=10) and psychiatrically normal control donors (n=13). DNA oxidation was also measured in BA10 white matter of schizophrenia donors (n=10) and in prefrontal cortical white matter from control rats (n=8) a

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9

Baker, Stephanie. "Modeling Depression in the Rat: The Development and Usefulness of a Female-centric Approach." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20211.

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Women are twice as likely to suffer from depression as men, yet stress and depression research has relied primarily on the responses of males. Early life stress is hypothesized to influence the development of vulnerability to depression while adult stress exposure can act as a trigger in those predisposed. This relationship is mediated by other environmental factors. Maternal care and the social environment appear to be particularly important for mammals. The purpose of this thesis was twofold: to develop an animal model of depression for use in female rats based on the chronic mild stress (CM

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10

Morris, Bethany H. "The Effect of Stress on Hedonic Capacity in Generalized Anxiety Disorder: A Prospective Experimental Study of One Potential Pathway to Depression." Scholar Commons, 2009. https://scholarcommons.usf.edu/etd/1716.

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A growing body of work links psychopathology to changes in hedonic capacity following stressors. This was the first experimental study of the effects of stress on hedonic capacity in an analog generalized anxiety disorder (GAD) sample (a high worry group). Specifically, we utilized an experimental manipulation of stress and a behavioral index of anhedonia to test the hypothesis that individuals with GAD, who are at higher risk for developing depression symptoms, exhibit greater stress-related deficits in hedonic capacity than do nonanxious controls. Further, this study assessed whether stress-

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11

Payet, Jeanne. "Phénoménologie clinique des conduites suicidaires de l'adolescent, à partir d'une étude de 50 patients hospitalisés." Bordeaux 2, 1997. http://www.theses.fr/1997BOR23058.

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12

Coleman, Joshua B., Wesley Drew Gill, Allee C. Maxwell, and Russell W. Brown. "Analysis of a Poly(ADP-ribose) Polymerase (PARP) Inhibitor in a Treatment-resistant Depression Model in the Rat." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/53.

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Over 16 million people in the US suffer from major depressive disorder (MDD) each year. Approximately 1/3rd of MDD patients (~5 million) obtain only partial remission or no benefit after trials with multiple drugs or drug combinations. Recently, Ordway and colleagues have reportedelevated levels of DNA oxidation and upregulated gene expression of the base excision repair enzyme poly(ADP-ribose) polymerase-1 (PARP1) in postmortem brain from donors who had MDD at the time of death, as compared to age-matched psychiatrically normal control donors. This study was designed to test whether an inhibi

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13

Craft, Tara K. S. "Psychological determinants of stroke outcome in mice." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1150315601.

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14

Keränen, A. M. (Anna-Maria). "Lifestyle interventions in treatment of obese adults:eating behaviour and other factors affecting weight loss and maintenance." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294457.

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Abstract The prevalence of working-aged weight losers is high because of high prevalence of obesity. Unfortunately, the loss of weight is often temporary. The aim of the present study was to investigate the effect of intensive counselling on maintained weight loss and eating behaviour (cognitive restraint, emotional eating, uncontrolled eating and binge eating). Additionally, the associations of eating behaviour with maintained weight loss, discontinuation, dietary intake and anhedonia were studied. Eighty-two overweight or obese subjects (body mass index >27) participated in either intens

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15

Macedo, Isabel Cristina de. "Modelo de obesidade e estresse crônico em ratos wistar : avaliação do comportamento alimentar, de anedonia e de níveis centrais de BDNF." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/122348.

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A obesidade tornou-se um dos mais graves problemas de saúde pública em todo o mundo, e o aumento na ingestão de alimentos hipercalóricos tem contribuído significativamente para o desenvolvimento desta doença. Este distúrbio metabólico pode ocasionar diversas outras comorbidades. Por outro lado, o estresse crônico, seja associado à obesidade ou não, leva a diferentes alterações neuroendócrinas e psicológicas. Estruturas cerebrais, especialmente o hipotálamo, estão envolvidas no controle do apetite. Atualmente, o hipocampo também tem sido associado ao controle do consumo alimentar. Neste context

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16

Alexander, Laith. "Primate ventromedial prefrontal cortex and the physiological and behavioural dysfunction characteristic of mood and anxiety disorders." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288429.

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The heterogeneity intrinsic to the ventromedial prefrontal cortex (vmPFC) is evidenced in both its anatomy and implicated function: vmPFC subregions have roles in positive affect, negative affect and autonomic/endocrine regulation. Whether different subregions serve fundamentally different functions, or whether they perform similar computations on different inputs, remains unclear. Nevertheless, the role of the vmPFC in psychopathology is widely appreciated - in mood and anxiety disorders, over-activity within constituent regions of the vmPFC is consistently implicated in symptomatology, toget

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17

Christ, Nicole M. "Psychophysiological Correlates of Novel, Negative Emotional Stimuli in Trauma-Exposed Participants with PTSD Symptoms." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1534160952853362.

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18

Prévot, Thomas. "Pathogénicité du stress chronique chez l'adulte dans un modèle murin : impact à long terme et rôle de la somatostatine." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0321/document.

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Le stress a une fonction adaptative mais son influence délétère sur la santé physique,cognitive et mentale lorsqu’il se présente de façon excessive et/ou chronique est aujourd’huireconnue. De très nombreux travaux ont démontré que le jeune enfant, l’adolescent et le sujetâgé y sont particulièrement vulnérables. L’objectif de cette thèse a été de déterminer s’ilexiste une sensibilité au stress chronique chez l’adulte selon l’âge au moment de l’exposition.Le modèle de stress chronique léger et imprédictible mis au point chez la souris a été utilisé.Les impacts à court et long-terme (sujet âgé),

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19

Goldberg, Yael. "Establishing the Construct of Boredom as Distinct From Apathy, Anhedonia and Depression." Thesis, 2008. http://hdl.handle.net/10012/3911.

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Boredom is a common human experience that has received little attention in the literature. To date, researchers have been unable to agree on a unified theory and definition of the construct. The present study investigated the nature of boredom by exploring its relationship to three phenomenologically similar affective states, namely apathy, anhedonia and depression. Structural equation modeling revealed that although related to apathy, anhedonia and depression to varying degrees, boredom is an empirically distinct construct. Establishing boredom as an independent construct provides an importan

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20

Barr, Alasdair McMillan. "The development of an animal model of depression : a focus on anhedonia." Thesis, 2001. http://hdl.handle.net/2429/13495.

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Depression is one of the more frequent psychiatric disorders, that continues to exact a tremendous cost to society, in both human and financial terms. Novel therapies for the treatment of this disorder will originate from preclinical research, which is based upon the use of animal models. In the current dissertation, we describe the development of two animal models of depression. The first three experiments describe in detail a series of studies that were conducted to provide further validation of the Chronic Mild Stress (CMS) model of depression. Despite initially promising results in Experim

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21

Chang, Ling, and 張琳. "The Role of Mindfulness in Depression Treatment for Anhedonia: A Study of Psychological Mechanisms." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/bkwpnh.

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碩士<br>國立臺灣大學<br>心理學研究所<br>107<br>Research and therapy on depression to date have predominantly focused on negative emotional experiences. However, a deﬁcit in the ability to experience positive emotions is one of the core symptoms of depression, referred to as anhedonia. The present research enumerates three domains of anhedonia in depression, namely, past recollection, present experiences, and future expectation. Accordingly, this study postulates possible psychological mechanisms on how positive emotions are impacted under the above three domains and investigate whether anhedonia and the qua

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22

Huang, Debbie. "Testing the Assumptions of the Network Paradigm for Studying Depression." Thesis, 2021. https://doi.org/10.7916/d8-exf0-1277.

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Depression is a major public health problem. Decades of research have been conducted to create a classification system aligned with the complex phenomenological features of depression. The dominant classification system for depression is the latent paradigm, which conceptualizes observable symptoms of depression as effects of an underlying disorder. There is increasing evidence, however, that the latent model is inadequate to inform the prognosis and treatment of depression. Specifically, evidence is accumulating that symptoms of depression do not necessarily arise due to an underlying condit

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23

Slabbert, Francois Naude. "An analysis of antidepressant noncompliance in the private health sector of South Africa / Francois Naude Slabbert." Thesis, 2014. http://hdl.handle.net/10394/15553.

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The main aim of the thesis was to measure antidepressant (AD) non-compliance, to determine which factors are closely associated with AD non-compliance and the consequences of prolonged AD non-compliance in the private health sector of South Africa. The empirical study followed an observational, prospective, cohort study using longitudinal medicine claims data provided by a nationally representative Pharmaceutical Benefit Management company (PBM) from 1 January 2006 to 31 December 2011. Failure to respond to AD treatment and achieving remission has severe neurobiological and clinical consequenc

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24

Romeas, Thomas. "Changements dans le circuit de la récompense suite à la bulbectomie olfactive : une nouvelle approche pour étudier des antidépresseurs." Thèse, 2009. http://hdl.handle.net/1866/2975.

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La dépression est une maladie chronique, récurrente et potentiellement mortelle qui affecte plus de 20 % de la population à travers le monde. Les mécanismes sous-jacents de la dépression demeurent incompris et la pharmacothérapie actuelle, largement basée sur l’hypothèse monoaminergique, fait preuve d’une efficacité sous optimale et d’une latence thérapeutique élevée. Par conséquent, la recherche est amenée à élaborer de nouveaux traitements pharmacologiques. Pour détecter leur action, il est avant tout nécessaire de développer des outils expérimentaux adéquats. Dans cette optique, notre but a

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