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Dissertations / Theses on the topic 'Animal model'

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1

Brännström, Åke. "Modelling animal populations." Doctoral thesis, Umeå universitet, Matematik och matematisk statistik, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205.

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This thesis consists of four papers, three papers about modelling animal populations and one paper about an area integral estimate for solutions of partial differential equations on non-smooth domains. The papers are: I. Å. Brännström, Single species population models from first principles. II. Å. Brännström and D. J. T. Sumpter, Stochastic analogues of deterministic single species population models. III. Å. Brännström and D. J. T. Sumpter, Coupled map lattice approximations for spatially explicit individual-based models of ecology. IV. Å. Brännström, An area integral estimate for higher order
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2

Camus, Sandrine. "Etho-Psychiatry : animal model to model animal : Identification of a « spontaneous » non-human primate model of depressive symptoms." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22032/document.

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Plus de 150 millions de personnes souffrent de troubles dépressifs à travers le monde. Malgré le nombre croissant d’études s’intéressant à la physiopathologie de ce trouble, aucune amélioration majeure concernant ses traitements ou la compréhension des mécanismes biologiques sous-jacents n’a été faite. Bien qu’une prédisposition génétique et des évènements stressants aient été proposés comme facteurs de risque, ni les gènes impliqués ni le fonctionnement des interactions gène x environnement ne sont encore connus. Cela peut s’expliquer par le manque de modèles animaux satisfaisants et par le f
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3

Cullen, J. R. "Sudden hearing loss : an animal model." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326426.

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4

Stewart, Richard James. "Aspects of unilateral cryptorchidism : an animal model." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336195.

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5

Godinho, Sofia Isabel Henriques. "An animal model of acute lung injury." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424508.

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6

Parsons, Sven David Charles. "Natural animal model systems to study tuberculosis." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4505.

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Thesis (PhD (Molecular Biology and Human Genetics))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: The growing global epidemic of human tuberculosis (TB) results in 8 million new cases of this disease and 2 million deaths annually. Control thereof will require greater insight into the biology of the causative organism, Mycobacterium tuberculosis, and into the pathogenesis of the disease. This will benefit the design of new vaccines and diagnostic assays which may reduce the degree of both disease transmission and progression. Animal models have played a vital role in the understandin
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7

Friedenberg, Steven Gene. "The role of mitochondrial DAMPs on the inflammatory response in an in vitro model of canine SIRS." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365174635.

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8

Faig, Martí Jordi. "Nou model animal experimental per a l'artrosi precoç." Doctoral thesis, Universitat de Barcelona, 2003. http://hdl.handle.net/10803/1207.

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Introducció: Les malalties que afecten el sistema locomotor produeixen una gran limitació en la funcionalitat de la població, especialment en les edats avançades de la vida. Per progressar en el coneixement de l'artrosi es va engegar el treball que presentem, com a model experimental que permetés estudiar tractaments en un model animal per a les fases inicials d'aquesta malaltia.<br/>Material i Mètode: Per portar a terme l'estudi es van utilitzar 15 bens adults de 3 anys d'edat. En condicions d'asèpsia, el grup d'animals és sotmès a una intervenció al genoll esquerre per crear una lesió condra
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9

Mercer, David Frederick. "Development of an animal model of hepatitis C." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0009/NQ60004.pdf.

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10

Munguia, Raymundo. "CiprofloxacinDexamethasone ototoxicity in an animal and human model." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97975.

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Introduction. Ototoxicity refers to medication-caused auditory and/or vestibular system dysfunction resulting in hearing loss or dysequilibrium. The potential damage that antibiotics eardrops can produce when placed directly into the middle ear in some cases is still unknown.<br>Objectives. To determine the safety of use of the new ciprofloxacin/dexamethasone otic drops in patients without an intact tympanic membrane.<br>Materials and methods. Ciprodex/dexamethasone eardrops were tested in an animal and human model. The animal part was performed in 13 adult chinchillas; Auditory Brainstem Resp
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11

Qasim, Faieza Jabeen. "Study of an animal model of experimental vasculitis." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361670.

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12

Hallam, B. "Simulating animal conditioning : investigating Halperin's neuro-connector model." Thesis, University of Edinburgh, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.651976.

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This dissertation describes simulation work which starts an investigation into Halperin's [1990] claim that her Neuro-Connector model is 'plausible as a general model of vertebrate learning'. One way of testing a claim such as this is to examine the model's ability to reproduce learning phenomena which are <i>not</i> part of the model's development history. Choosing a phenomenon which is <i>not</i> one of those that the model was specifically built to reproduce tests the model's ability to generalise. This gives creedance to the claim that the model represents or explains some actual underlyin
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13

Leung, Wai-hin, and 梁瑋軒. "Neurogenesis in animal model of systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/209497.

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Systemic Lupus Erythematosus (SLE) is an autoimmune disease which is characterized by high level of autoantibody detected in the body. This disease is female predominant with a male to female ratio 1: 9. SLE could cause damage to different organ systems and central nervous system is one of them. Patients diagnosed with SLE could suffer from psychiatric problems like cognitive dysfunction, depression and anxiety. Neurogenesis refers to the process by which new neurons are generated. Although it has been widely reported that neurogenesis could be enhanced under pathological conditions such as
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14

Chaniary, Kunal. "Electrophysiological Analysis in an Animal Model of Dystonia." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/93.

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Dystonia is a movement disorder characterized by patterned, repetitive, and sustained muscle contractions that cause ineffective and often painful movements. The overall goal of this project was to understand the physiological mechanisms of dystonia in a rodent model as a basis for developing innovative treatments for secondary dystonias. The first half of the project was focused at developing essential techniques for systematically investigating the movement disorder in these animals. For achieving this, an innovative, multi-faceted approach was pursued starting with electromyographic (EMG) a
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15

Chaniary, Kunal Dilip. "Electromyographic Characterization in an Animal model of Dystonia." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/648.

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Kernicterus causes damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulfadimethoxine to exacerbate bilirubin neurotoxicity and compared to saline treated jjs and non-jaundiced (Nj) littermates. Electromyographic (EMG) activity was recorded from antagonistic hip muscles in dystonic and in normal ap
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16

Bellwald, Dominik. "The avascular talus : revascularization in an animal model /." Bern : [s.n.], 2004. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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17

DuBose, Candis Schrelle. "An animal model for discogenic low back pain." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/794.

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Low back pain is a debilitating condition that afflicts millions of people each year. It is characterized by complex biochemical, morphological, and biomechanical changes. However, most believe low back pain arises due to abnormal mechanical loading, inflammation, and disc degeneration. Several studies have investigated radial back pain, but to date, there is only one in vivo animal model for low back pain. Despite advances in science, the causes of low back pain remain unclear and treatments fail to relieve the pain. To better understand the causative factors of low back pain, a reliable anim
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18

Albertí, i. Fitó Glòria. "Model animal en laminectomia lumbar: factors quirúrgics i variabilitat individual." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/381247.

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La cirurgia del raquis lumbar ha augmentat substancialment amb el pas dels anys i això ha condicionat la pràctica de força estudis, tant clínics com experimentals, per millorar les tècniques, fer-les més eficients i segures pel pacient. Malgrat tot, aquestes intervencions presenten un índex de fracassos que es situen entre el 5 i el 50%, segons la literatura. Una de les possibles causes de fracàs és la fibrosi postquirúrgica. Sobre la fibrosi s’han fet nombrosos estudis, tant per acceptar que pot ser causa de dolor postoperatori com per rebutjar aquesta teoria. A més a més ha motivat un plegat
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19

Galuppo, Andrea Giannotti. "Avaliação da sensibilidade de zigotos murinos à Brucella abortus para o estabelecimento de um modelo experimental em estudos de interações embriões-patógenos." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-23082007-141648/.

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Os objetivos desse trabalho foram avaliar in vitro a sensibilidade de zigotos murinos à Brucella abortus, assim como a eficácia das lavagens seqüenciais e do tratamento com tripsina, padronizados pela International Embryo Transfer Society, na sua remoção e/ou inativação, a fim de estabelecer um modelo acessível para o estudo de interações embriões-patógenos. Para a coleta dos zigotos, foram utilizados camundongos fêmeas (Swiss Webster), púberes, nulíparas, 6-8 semanas de idade, acasaladas com machos inteiros da mesma linhagem, após superestimulação ovariana. Para a in
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20

Cully, Louise. "Biomechanical and physiological investigations in the IBMPFD animal model." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59209/.

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Inclusion body myopathy associated with Paget’s disease of bone and frontotemporal dementia (IBMPFD; OMIM 167320) is an autosomal dominant inherited multisystem disorder caused by mutations in the valosin-containing protein (VCP) gene. Knock-in mice expressing the common human p.R155H VCP mutation develop a progressive myopathy with ubiquitin-positive inclusion bodies, accumulation of abnormally shaped mitochondria in skeletal muscle and focal bone degradation reminiscent of Paget’s disease of bone. To further assess the physiological effects of this mutation in muscle, we compared the in vitr
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21

Colantonio, David A. "Troponin modifications, from animal model to the Emergency Department." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ65612.pdf.

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22

Richards, Sonja. "An animal model of autism : remediation with tactile stimulation." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011, 2011. http://hdl.handle.net/10133/3126.

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This thesis examines both behavioral and anatomical effects of prenatal exposure of Valproic Acid (VPA) on Long Evans rats. Tactile stimulation (TS) is then used to investigate its’ effect on remediating any abnormalities VPA may produce. Several behavioral tests were done to assess the behavioral effects of VPA and TS. It was found that VPA had an effect of many of the tasks, whereas, TS had almost none with the exception of an effect on females in the elevated plus maze. However, anatomical data showed that TS had a profound effect on neuronal branch order, cell complexity, and spine density
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23

Tucker, Lawrence Maskew. "Neural transplantation in an animal model for Huntington's disease." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362863.

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24

Najjar, Deborah Anne. "Towards a more ethical animal model in biomedical research." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120675.

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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages [69]-[75]).<br>Since the early twentieth century, mice have emerged as the standard mammalian model organism for biomedical research. When pain relief is provided during experimentation, it typically comes in the form of transient and sometimes ineffective analgesics or anesthesia. This thesis proposes an alternative to the current method of research in the form of an engineered
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25

Maglennon, G. A. "Study of papillomavirus latent infection in an animal model." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1306763/.

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Papillomaviruses cause a wide spectrum of benign and neoplastic diseases in humans and animals. They may also cause infections that are characterised by the absence of clinical signs of disease and some of these may represent viral latency. Many viruses have a latent stage of their life cycle and papillomaviruses appear to be no different. For example, some low-risk human papillomavirus types such as HPV-11 and HPV-6 can cause infections that resemble latency. It has recently been shown that rabbit oral papillomavirus (ROPV) is an appropriate model of these virus types. Infection of the tongue
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26

Pomeroy, Ian. "Neocortical lesions in an animal model of multiple sclerosis." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670186.

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27

Alexander, Kathleen Shannon. "Elevated Kynurenic Acid as an Animal Model of Schizophrenia." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1304691359.

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28

Remus, Jennifer Lynn. "Neuroimmune Mechanisms of an Animal Model of Recurrent Depression." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1429197762.

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29

Tse, Yiu Chung. "Glutamate receptors in an animal model of Parkinson's disease." HKBU Institutional Repository, 1999. http://repository.hkbu.edu.hk/etd_ra/226.

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30

Saijo(Kim), Misa. "Generation of transgenic animal model of hyperthyroid Graves' disease." Kyoto University, 2004. http://hdl.handle.net/2433/147457.

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31

Glennie, Richard. "Incorporating animal movement with distance sampling and spatial capture-recapture." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/16467.

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Distance sampling and spatial capture-recapture are statistical methods to estimate the number of animals in a wild population based on encounters between these animals and scientific detectors. Both methods estimate the probability an animal is detected during a survey, but do not explicitly model animal movement. The primary challenge is that animal movement in these surveys is unobserved; one must average over all possible paths each animal could have travelled during the survey. In this thesis, a general statistical model, with distance sampling and spatial capture-recapture as special cas
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32

Muehlmann, Amber M. "Pharmacological challenges of an animal model of self-injurious behavior." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011875.

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33

Diller, James W. "Development of an animal model of choice between aversive events." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4916.

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Thesis (M.S.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains vii, 68 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 63-65).
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34

Rudissaar, Ruth. "Neuropharmacology of atypical antipsychotics and an animal model of psychosis /." Online version, 2006. http://dspace.utlib.ee/dspace/bitstream/10062/1294/5/rudissaarruth.pdf.

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35

Schiel, Thomas. "Arthroscopic transfer of osteochondral allografts in a bovine animal model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq31898.pdf.

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36

Poirier, Denise Marie. "Nutrient absorption from liquid therapeutic diets in an animal model." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61694.

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37

Waters, C. M. "A cytochemical evaluation of an animal model of Parkinson's disease." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377231.

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38

Hawkins, C. A. "Some studies on an animal model of temporal lobe epilepsy." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375246.

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39

Haberzettl, Robert [Verfasser]. "A validated animal model for the Serotonin Syndrome / Robert Haberzettl." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1077211929/34.

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40

Omar, Rumana Zareen. "A multistate model for the analysis of animal tumourigenicity experiments." Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303167.

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41

Stapley, Sarah A. "Experimental studies of resuscitation following hypovolaemia in an animal model." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403821.

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42

Best, Nicholas James. "Paravalbumin-immunoreactive hippocampal neurons in an animal model of epilepsy." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296242.

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43

Binello, Emanuela. "Efficacy of boron neutron capture synovectomy in an animal model." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85314.

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44

Resende, Ana Paula Simões Nunes de. "Study on erythropoietin subconjunctival administration in a glaucoma animal model." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16041.

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Tese de Doutoramento em Ciências Veterinárias na Especialidade de Clinica<br>Glaucoma is the number one cause of irreversible vision loss worldwide. Death of retinal ganglion cells (RGC), which results in the progressive loss of visual function, occurs in glaucoma and other ocular diseases caused by hypoxia and ischemia. Although glaucoma is a multifactorial neurodegenerative disease, the only currently method of treatment involves reduction of intraocular pressure and, at the present, there is no effective treatment to prevent RGC apoptosis. Notably, it has been reported that erythropoietin (
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45

Man, James K. C. "Characterisation of a novel animal model for obsessive-compulsive disorder." Thesis, University of Bristol, 2005. http://hdl.handle.net/1983/6cec00ce-f3c1-4d07-ba98-54c137b7524a.

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46

Schultes, Klaus. "Ultrastructural characterization of ultraviolet induced corneal disease : an animal model." Master's thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/27046.

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The majority of ancient people worshipped the sun and viewed it as a health - bringing deity. During the eighteenth and nineteenth century therapeutic benefits of sunlight exposure were beginning to be understood and by the end of the nineteenth century the importance of ultraviolet radiation was being realized. Danish physician Niels Finsen, whom many regard as the father of ultraviolet phototherapy, also stressed that it was ultraviolet radiation in the solar spectrum which cause sunburn. We now recognize that the small portion of ultraviolet radiation which reaches the earth's surface is no
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Monreal, Gretel. "Ventricular Remodeling in a Large Animal Model of Heart Failure." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1210007937.

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48

Roland, Jessica Justine. "Septohippocampal system modulation in an animal model of diencephalic amnesia." Diss., Online access via UMI:, 2008.

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Anzalone, Steven J. "Cholinergic cortical dysfunction in an animal model of diencephalic amnesia." Diss., Online access via UMI:, 2009.

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50

TROVATELLI, MARCO. "SHEEP AS ANIMAL MODEL IN MINIMALLY INVASIVE NEUROSURGERY IN EDEN2020." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/707384.

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Glioblastomas (GBMs) is a malignant type of central nervous system tumours and its presentation is almost 80% of all malignant primary brain neoplasia. This kind of tumour is highly invasive infiltrating the white matter area and is confined to the central nervous with a very poor patient outcome survival around 10 months. Of the existing treatment approaches, Convection Enhanced drug Delivery (CED) offers several advantages for the patient but still suffers from significant shortcomings. Enhanced Delivery Ecosystem for Neurosurgery in 2020 (EDEN2020) is a European project supported with a new
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