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Journal articles on the topic 'Animal model'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Insel, Thomas R. "From Animal Models to Model Animals." Biological Psychiatry 62, no. 12 (2007): 1337–39. http://dx.doi.org/10.1016/j.biopsych.2007.10.001.

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Wuri, Rahmitiana, Aziis Mardanarian Rosdianto, and Hanna Goenawan. "UTILIZATION OF RATS AS BLUNT TRAUMA ANIMALS MODEL: A LITERATURE REVIEW." Indonesia Medicus Veterinus 10, no. 2 (2021): 338–54. http://dx.doi.org/10.19087/imv.2021.10.2.338.

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The occurrence of contusion in humans and animals becomes an interesting study material, many researchers search and do a treatment formulation for contusion. The various effects of applying a new substance/drug to humans can be determined by studying cumulative effect of doses at the preclinical stage. The information was obtained from conducting laboratory experiments in vivo using experimental animals as a model designed in preclinical tests, such as using rats (Rattus norvegicus). So far, the development of using rat as an animal model of contusion is still very potential for further study

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3

Shimamura, Tsuyoshi, Nobuo Kubota, and Kazutoshi Shibuya. "Animal Model of Dermatophytosis." Journal of Biomedicine and Biotechnology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/125384.

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Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host’s normal immune function. Many scientists have attempted to establish an experimental animal model to elucidate the pathogenesis of human dermatophytosis and evaluate drug efficacy. However, current animal models have several issues. In the present paper, we surveyed reports about the methodology of the dermatophytosis animal model for tinea corpor

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4

Oh, Chang Seok, and Dong Hoon Shin. "Making an animal model for Korean mummy studies." Anthropologischer Anzeiger 71, no. 4 (2014): 469–88. http://dx.doi.org/10.1127/0003-5548/2014/0360.

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5

Flaisher-Grinberg, S., N. Kronfeld-Schor, and H. Einat. "Models of mania: from facets to domains and from animal models to model animals." Journal of Psychopharmacology 24, no. 3 (2008): 437–38. http://dx.doi.org/10.1177/0269881108097905.

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6

Frazer, Alan, and David A. Morilak. "What should animal models of depression model?" Neuroscience & Biobehavioral Reviews 29, no. 4-5 (2005): 515–23. http://dx.doi.org/10.1016/j.neubiorev.2005.03.006.

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7

Tulving, Endel, and Hans J. Markowitsch. "What do animal models of memory model?" Behavioral and Brain Sciences 17, no. 3 (1994): 498–99. http://dx.doi.org/10.1017/s0140525x00035664.

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8

Jones, I. H., D. M. Stoddart, and J. Mallick. "Towards a Sociobiological Model of Depression a Marsupial Model (Petaurus breviceps)." British Journal of Psychiatry 166, no. 4 (1995): 475–79. http://dx.doi.org/10.1192/bjp.166.4.475.

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BackgroundThis is a sociobiological approach to depression using hierarchy and its hypothesised relevance to self-esteem in the marsupial sugar glider (Petaurus breviceps).MethodDifferential access to resources between the dominant and submissive animal is measured by observation in four stable colonies. The dominant animals from two of these colonies are then introduced into the other two, resulting in the transferred former dominants becoming subordinate. Behavioural and biochemical measures relevant to depression and involving access to resources are then repeated. These measures include ea

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9

Lang, Yolanda C. "Animal Exposure Surveillance: A Model Program." AAOHN Journal 53, no. 9 (2005): 407–12. http://dx.doi.org/10.1177/216507990505300907.

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In 1996, the Institute of Laboratory Animal Resources published guidelines for a mandatory occupational health program for personnel who work in animal facilities. This article details the development and implementation of an animal exposure surveillance program (AESP) at a large educational research institution. Prior to initiation of an AESP, the occupational health practitioner must develop a database and health inventory to allow collection, storage, and communication of pertinent employee and animal information; review the health inventory with each employee; administer necessary vaccinat

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10

Bečić, F., Z. Mornjaković, I. Zulić, et al. "Animal model of thermal injuries." Bosnian Journal of Basic Medical Sciences 3, no. 4 (2003): 41–46. http://dx.doi.org/10.17305/bjbms.2003.3492.

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Experimental studies of burns require the use of different animal models with the aim to imitate and reproduce pathophysiological conditions. The aim of this work was to establish experimental model of thermal injury.New Zealand rabbits, weighted from 1.8 kg to 2.3 kg, were utilised during our study. Another, also utilized, animal types were laboratory Rattus rats, species Wistar, albino type, females with body weight of about 232 g. All animals were from our own litter (Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine in Sarajevo). During the experiment, an

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11

David, Vlad-Laurentiu, Bogdan Ciornei, Florin-George Horhat, et al. "Rat Animal Model of Pectus Excavatum." Life 10, no. 6 (2020): 96. http://dx.doi.org/10.3390/life10060096.

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Background: pectus excavatum (PE) is the most common congenital deformity of the thoracic wall. Lately, significant achievements have been made in finding new, less invasive treatment methods for PE. However, most of the experimental work was carried out without the help of an animal model. In this report we describe a method to create an animal model for PE in Sprague-Dawley rats. Methods: We selected 15 Sprague-Dawley rat pups and divided them into two groups: 10 for the experimental group (EG) and 5 for the control group (CG). We surgically resected the last four pairs of costal cartilages

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12

Corcilius, Klaus, and Pavel Gregoric. "Aristotle’s Model of Animal Motion." Phronesis 58, no. 1 (2013): 52–97. http://dx.doi.org/10.1163/15685284-12341242.

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Abstract In this paper we argue that Aristotle operates with a particular theoretical model in his explanation of animal locomotion, what we call the ‘centralized incoming and outgoing motions’ (CIOM) model. We show how the model accommodates more complex cases of animal motion and how it allows Aristotle to preserve the intuition that animals are self-movers, without jeopardizing his arguments for the eternity of motion and the necessary existence of one eternal unmoved mover in Physics VIII. The CIOM model helps to elucidate Aristotle’s two central yet problematic claims, namely that the sou

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Dey, Nandini, Yuliang Sun, Brian Leyland-Jones, and Pradip De. "Evolution of Tumor Model: From Animal Model of Tumor to Tumor Model in Animal." Journal of Cancer Therapy 04, no. 09 (2013): 1411–25. http://dx.doi.org/10.4236/jct.2013.49168.

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14

Guidetti, Roberto, Laura Baraldi, Caterina Calzolai, Lorenza Pini, Paola Veronesi, and Aurora Pederzoli. "Fantastic animals as an experimental model to teach animal adaptation." BMC Evolutionary Biology 7, Suppl 2 (2007): S13. http://dx.doi.org/10.1186/1471-2148-7-s2-s13.

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15

Fischer, K. M. "Transgenic domestic animals provide an animal model for rheumatoid arthritis." Medical Hypotheses 38, no. 3 (1992): 240–43. http://dx.doi.org/10.1016/0306-9877(92)90102-i.

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16

Montenegro, Omar, Soledad Illescas, José Carlos González, et al. "Development of animal experimental model for bacterial peritonitis." Revista Española de Quimioterapia 33, no. 01 (2020): 18–23. http://dx.doi.org/10.37201/req/064.2019.

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17

Collins, Francis S., and James M. Wilson. "A welcome animal model." Nature 358, no. 6389 (1992): 708–9. http://dx.doi.org/10.1038/358708a0.

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18

Treasure, Janet, and Laura Eid. "Eating disorder animal model." Current Opinion in Psychiatry 32, no. 6 (2019): 471–77. http://dx.doi.org/10.1097/yco.0000000000000550.

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19

Marx, Preston A., and J. Moor-Jankowski. "AIDS Animal Model Center." Journal of Medical Primatology 23, no. 1 (1994): 63. http://dx.doi.org/10.1111/j.1600-0684.1994.tb00102.x.

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Marx, Preston A., and J. Moor-Jankowski. "AIDS Animal Model Center." Journal of Medical Primatology 23, no. 2-3 (1994): 226. http://dx.doi.org/10.1111/j.1600-0684.1994.tb00121.x.

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21

Kim, Hyun Ah, and Eun Jeong Cheon. "Animal Model of Osteoarthritis." Journal of Rheumatic Diseases 19, no. 5 (2012): 239. http://dx.doi.org/10.4078/jrd.2012.19.5.239.

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22

Anderson, Debra F., and J. Job Faber. "Animal model for polyhydramnios." American Journal of Obstetrics and Gynecology 160, no. 2 (1989): 389–90. http://dx.doi.org/10.1016/0002-9378(89)90454-7.

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23

Luo, Junchao, Zetao Wang, Chenqi Tang, et al. "Animal model for tendinopathy." Journal of Orthopaedic Translation 42 (September 2023): 43–56. http://dx.doi.org/10.1016/j.jot.2023.06.005.

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24

Grunwald, I. Q., B. Romeike, R. Eymann, C. Roth, T. Struffert, and W. Reith. "An Experimental Aneurysm Model: A Training Model for Neurointerventionalists." Interventional Neuroradiology 12, no. 1 (2006): 17–24. http://dx.doi.org/10.1177/159101990601200104.

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Reproducible animal models not only facilitate the pre-clinical assessment of aneurysm therapy but can also help in training for interventional procedures. The objective of this study was to find an animal model that can be used to test different endovascular occlusion techniques. Aneurysms in the right common carotid artery were created in 35 NZW rabbits by distal ligation and intraluminal elastase infusion. A total of 27 aneurysms were occluded by endovascular embolization with GDC-Coils. The time needed for placement of the microcatheter into the aneurysm by a professional interventionalist

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25

Araujo, Vinicius Albano. "Ocean Literacy Strategies Using Flag Animal as Environmental Awareness Model." International Journal of Zoology and Animal Biology 7, no. 1 (2024): 1–9. http://dx.doi.org/10.23880/izab-16000554.

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In recent decades, anthropogenic pressures associated with the unsustainable use of resources have threatened the health of the oceans and the dynamics of life. Considering the importance of marine resources for the economy and maintaining the diversity of life on earth, effective and immediate measures are necessary to raise society's awareness of changes and the adoption of sustainable lifestyle habits. To this end, the United Nations (UN) created the decade of the oceans, 2020-2030, compiling a series of actions worldwide that can minimize impacts on marine ecosystems. One of the ways to re

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26

Narkhede, Mahesh B., Pavan P. Chinchole, Mangesh N. Deokar, et al. "ZEBRA FISH: AN EXPERIMENTAL MODEL FOR DRUG SCREENING." Journal of Advanced Scientific Research 14, no. 11 (2023): 1–6. http://dx.doi.org/10.55218/jasr.2023141101.

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Animal models have provided invaluable information in biological evaluation and drug screening. It comes to predicting the human body’s response to candidate drugs; traditional laboratory animal models are woefully inadequate. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues.In this review, we seek to summarize the important anatomical aspects of Zebra fish as it is used as an alternative animal model for drug screening.

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27

Peterson, Mark E. "ANIMAL MODELS OF DISEASE: Feline hyperthyroidism: an animal model for toxic nodular goiter." Journal of Endocrinology 223, no. 2 (2014): T97—T114. http://dx.doi.org/10.1530/joe-14-0461.

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Since first discovered just 35 years ago, the incidence of spontaneous feline hyperthyroidism has increased dramatically to the extent that it is now one of the most common disorders seen in middle-aged to senior domestic cats. Hyperthyroid cat goiters contain single or multiple autonomously (i.e. TSH-independent) functioning and growing thyroid nodules. Thus, hyperthyroidism in cats is clinically and histologically similar to toxic nodular goiter in humans. The disease in cats is mechanistically different from Graves' disease, because neither the hyperfunction nor growth of these nodules depe

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28

Cudd, Timothy A. "Animal Model Systems for the Study of Alcohol Teratology." Experimental Biology and Medicine 230, no. 6 (2005): 389–93. http://dx.doi.org/10.1177/15353702-0323006-06.

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The incidence of fetal alcohol syndrome has not been declining even though alcohol has been established as a teratogen and significant efforts have been made to educate women not to abuse alcohol during pregnancy. In addition to further educational efforts, strategies to prevent or mitigate the damages of prenatal alcohol exposure are now under development. Animal models will play a significant role in the effort to develop these strategies. Because prenatal alcohol exposure causes damage by multiple mechanisms, depending on dose, pattern, and timing of exposure, and because no species of anim

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29

Ladislav, Libich, Hruška Michal, Vaculík Petr, and Přikryl Miroslav. "The use of stereophotogrammetry to determine the size and spatial coordinates to generate a 3D model of an animal." Research in Agricultural Engineering 63, No. 2 (2017): 47–53. http://dx.doi.org/10.17221/65/2015-rae.

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This study considers the process of 3D scanning of farm animals using the method of stereophotogrammetry. This involves taking stereoscopic pictures of an animal, from which the spatial coordinates of selected anatomic points on the animal are determined using triangulation. These points are chosen in such a way to make it possible to determine from them the dimensions used in animal breeding databases and to draw a skeleton to be used in generating a 3D model of the animal. The dimensions of the animals were identified from this test group using an analysis of stereoscopic images and these we

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30

Hidayat, Rachmat, and Patricia Wulandari. "Protocol for Anesthesia Animal Model in Biomedical Study." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 3 (2021): 522–26. http://dx.doi.org/10.32539/bsm.v5i3.311.

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Recognition of pain depends upon intact pathways from pain receptors to thethalamus and cerebral cortex, as well as functional cerebral cortex and subcorticalstructures. Thus any means that renders the cerebral cortex nonfunctional, suchas hypoxia or drug depression, prevents pain. When this happens, stimuli thatevoke motor nerve reflexes that may be painful to the conscious animal are notpainful in the unconscious animal. Equally painful stimuli administered toanimals chemically paralyzed by curare or succinylcholine will not evoke a motorreflex simply because of paralysis, but will cause pai

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Hidayat, Rachmat, and Patricia Wulandari. "Protocol for Anesthesia Animal Model in Biomedical Study." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 7 (2021): 619–23. http://dx.doi.org/10.32539/bsm.v5i7.311.

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Recognition of pain depends upon intact pathways from pain receptors to thethalamus and cerebral cortex, as well as functional cerebral cortex and subcorticalstructures. Thus any means that renders the cerebral cortex nonfunctional, suchas hypoxia or drug depression, prevents pain. When this happens, stimuli thatevoke motor nerve reflexes that may be painful to the conscious animal are notpainful in the unconscious animal. Equally painful stimuli administered toanimals chemically paralyzed by curare or succinylcholine will not evoke a motorreflex simply because of paralysis, but will cause pai

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32

Urano, K., N. Tamaoki, and T. Nomura. "Establishing a Laboratory Animal Model From a Transgenic Animal." Veterinary Pathology 49, no. 1 (2011): 16–23. http://dx.doi.org/10.1177/0300985811430318.

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33

Prerona, Boruah, Bavaskar Komal, Deka Nikhita, and Yadav Aditya. "Beyond the petri dish: Model organisms in non-clinical exploration." World Journal of Advanced Research and Reviews 23, no. 1 (2024): 2540–53. https://doi.org/10.5281/zenodo.14823012.

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Animal models have been integral to scientific research for decades, offering invaluable insights into complex biological processes, advancing medical knowledge, and aiding the development of new treatments. This review explores the significance of animal models in various research fields, emphasizing their biological similarity to humans as a key factor. Animals, ranging from mice and rats to primates, fruit flies, and worms, share fundamental physiological, anatomical, and genetic characteristics with humans, making them crucial proxies for studying diseases and biological pathways. This rev

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34

Jaeger, P., W. Jones, M. Kashgarian, et al. "Animal model of primary hyperparathyroidism." American Journal of Physiology-Endocrinology and Metabolism 252, no. 6 (1987): E790—E798. http://dx.doi.org/10.1152/ajpendo.1987.252.6.e790.

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An experimental model of hyperparathyroidism was developed in the rat to simulate primary hyperparathyroidism in humans. In this model thyroparathyroidectomized (TPTX) or parathyroidectomized (PTX) animals were infused for 6 days with an amount of bovine synthetic parathyroid hormone (PTH)-(1-34) fragment to restore plasma calcium levels to normal (0.7 U X h-1) or with PTH at twofold (1.4 U X h-1) or threefold (2.1 U X h-1) this basal level. Animals infused with 2.1 U X h-1 of bovine PTH-(1-34) exhibited hypercalcemia, hypophosphatemia, a reduction in theoretical renal threshold for phosphate

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35

Krina, M. Patel* Bhavdip B. Parmar Divya M. Ramchandani and Brijesh R. Humbal. "Zebrafish: Model for Organ Toxicity Studies." Science World a monthly e magazine 2, no. 12 (2022): 2125–38. https://doi.org/10.5281/zenodo.7438316.

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Animal research is important for drug development as it focuses; On understanding the biology & genetics of living organisms, to understand disease etiology & progression, to identify potential biochemical pathways (targets for drugs) to mitigate diseases and for the advance understanding of illnesses such as cancer, AIDS, chronic pain & many other medical conditions. Animal testing focuses on understanding four facets: Pharmacokinetics, pharmacodynamics, efficacy & safety or toxicity. Using animals in research is extremely beneficial as they are biologically similar to humans

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36

Čabaravdić, Amra, Irfan Zulić, Zakira Mornjaković, Mirjana Mijanović, and Fahir Bečić. "Experimental model of the burn wound topical treatment." Bosnian Journal of Basic Medical Sciences 3, no. 4 (2003): 61–66. http://dx.doi.org/10.17305/bjbms.2003.3495.

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AbstractBACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burninducement and effects of the ointment containing natural plants on the process of burn healing.MATERIAL AND METHODS:Burn wounds were experimentally induced in two species of experimental animals which were treated with topically applied herbal preparation with concomitant monitoring of the healing process. Experimental groups (1) of 15 animals each (mice and rat

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37

Schueda, Marco Antonio, Moisés Cohen, Marcelo Salvador Filardi, Danielle do Rocio Brostulin, and Carlos José Serapião. "Modelo animal de lesão osteocondral em coelhos / Animal model of osteochondral injury in rabbits." Brazilian Journal of Development 7, no. 12 (2021): 118281–92. http://dx.doi.org/10.34117/bjdv7n12-541.

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38

Banakis Hartl, Renee M., Nathaniel T. Greene, Victor Benichoux, Anna Dondzillo, Andrew D. Brown, and Daniel J. Tollin. "Establishing an Animal Model of Single-Sided Deafness in Chinchilla lanigera." Otolaryngology–Head and Neck Surgery 161, no. 6 (2019): 1004–11. http://dx.doi.org/10.1177/0194599819877649.

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Objectives (1) To characterize changes in brainstem neural activity following unilateral deafening in an animal model. (2) To compare brainstem neural activity from unilaterally deafened animals with that of normal-hearing controls. Study Design Prospective controlled animal study. Setting Vivarium and animal research facilities. Subjects and Methods The effect of single-sided deafness on brainstem activity was studied in Chinchilla lanigera. Animals were unilaterally deafened via gentamycin injection into the middle ear, which was verified by loss of auditory brainstem responses (ABRs). Anima

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39

Parkkinen, Veli-Pekka. "Are Model Organisms Theoretical Models?" Disputatio 9, no. 47 (2017): 471–98. http://dx.doi.org/10.1515/disp-2017-0015.

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AbstractThis article compares the epistemic roles of theoretical models and model organisms in science, and specifically the role of non-human animal models in biomedicine. Much of the previous literature on this topic shares an assumption that animal models and theoretical models have a broadly similar epistemic role—that of indirect representation of a target through the study of a surrogate system. Recently, Levy and Currie (2015) have argued that model organism research and theoretical modelling differ in the justification of model-to-target inferences, such that a unified account based on

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40

Kasprzycki, Remigiusz. "Western Europe as a Model for Polish Defenders of Animal Welfare prior to 1939." Kwartalnik Historyczny 129, no. 6 (2023): 65–94. http://dx.doi.org/10.12775/kh.2022.129.si.1.03.

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This article looks at how Western Europe served as a model for Polish animal advocates before 1939. France and Great Britain inspired the greatest respect among Polish animal defenders. Polish animal lovers, fascinated by the French and English treatment of animals, discovered the effectiveness of grassroots initiatives, rather than legal resolutions and acts, for the welfare of animals. This article attempts to explain why the endeavour to copy the treatment of animals by wealthy Germans, French, and above all English and introduce it to economically poor Poland proved to be utopian.

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41

Koga, Hiroyasu. "Animal Model for Superficial Mycosis." Nippon Ishinkin Gakkai Zasshi 50, no. 2 (2009): 085–89. http://dx.doi.org/10.3314/jjmm.50.085.

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42

Kaveh. "Osteoporosis Induction in Animal Model." American Journal of Animal and Veterinary Sciences 5, no. 2 (2010): 139–45. http://dx.doi.org/10.3844/ajavsp.2010.139.145.

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43

INO, YOSHITAKA. "Natural sensitization allergy animal model." Japanese Journal of Clinical Immunology 13, no. 5 (1990): 460–62. http://dx.doi.org/10.2177/jsci.13.460.

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44

Spiegelmann, Roberto, William A. Friedman, Frank J. Bova, Daniel P. Theele, and J. Parker Mickle. "LINAC radiosurgery: an animal model." Journal of Neurosurgery 78, no. 4 (1993): 638–44. http://dx.doi.org/10.3171/jns.1993.78.4.0638.

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✓ Fifteen cats were irradiated with an animal LINAC (linear accelerator) radiosurgery device. After 6 months, they were studied with gadolinium-enhanced magnetic resonance (MR) imaging, gross pathology after Evans blue perfusion, and histopathology. The lesion size was relatively constant in the cats receiving a dose of 7500, 10,000, 12,500, or 15,000 cGy to the 84% isodose line of a 1-cm collimator. The composition of the lesion correlated with dose: the lower-dose lesions were found histologically to contain areas of edema, demyelination, reactive gliosis, and vascular proliferation; the hig

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45

Nishimura, Kazuko, and Makoto Miyaji. "Animal model of cerebral aspergillosis." Japanese Journal of Medical Mycology 29, no. 3 (1988): 195–201. http://dx.doi.org/10.3314/jjmm1960.29.195.

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46

Matsumoto, Isao. "2. Animal Model of Arthritis." Nihon Naika Gakkai Zasshi 101, no. 10 (2012): 2839–43. http://dx.doi.org/10.2169/naika.101.2839.

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&NA;. "New animal model for AIDS?" Inpharma Weekly &NA;, no. 1010 (1995): 11. http://dx.doi.org/10.2165/00128413-199510100-00028.

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Werawatganon, Duangporn. "Simple animal model ofHelicobacter pyloriinfection." World Journal of Gastroenterology 20, no. 21 (2014): 6420. http://dx.doi.org/10.3748/wjg.v20.i21.6420.

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49

Kim, Hae Kyu. "Animal Model of Cerebral Ischemia." Korean Journal of Anesthesiology 49, no. 3 (2005): 279. http://dx.doi.org/10.4097/kjae.2005.49.3.279.

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Raviola, Elio, and Torsten N. Wiesel. "An Animal Model of Myopia." New England Journal of Medicine 312, no. 25 (1985): 1609–15. http://dx.doi.org/10.1056/nejm198506203122505.

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