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Dissertations / Theses on the topic 'Anopheles gambiae Mosquitoes Malaria'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Kirk, Jeremy Mark. "The isolation of a Type II transposable element from Anopheles gambiae." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263782.

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2

Gary, Richard Eugene. "Biology of the malaria vector Anopheles gambiae behavioral and reproductive components of sugar feeding /." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1118936712.

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Thesis (Ph.D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 175 p.; also includes graphics. Includes bibliographical references (p. 160-175). Available online via OhioLINK's ETD Center

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3

Pinto, Sofia B. "Epithelial and cellular innate immune responses of Anopheline mosquitoes to Plasmodium parasites." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-73550.

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4

Waka, Maedot. "Native plants as repellents against malaria mosquitoes : ethnobotanical, behavioural & electrophysiological studies /." Uppsala : Dept. of Entomology, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200566-ab.html.

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5

Rono, Evans Kiplangat. "Variation in the Anopheles gambiae TEP1 Gene Shapes Local Population Structures of Malaria Mosquitoes." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18573.

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Die Allele (*R1, *R2, *S1 und *S2) des A. gambiae complement-like thioester-containing Protein 1 (TEP1) bestimmen die Fitness der Mücken, welches die männlichen Fertilität und den Resistenzgrad der Mücke gegen Pathogene wie Bakterien und Malaria-Parasiten. Dieser Kompromiss zwischen Reproduktion und Immunnität hat Auswirkungen auf die Größe der Mückenpopulationen und die Rate der Malariaübertragung. Wie die genetische Diversität von TEP1 die genetische Struktur natürlicher Vektorpopulationen beeinflusst, ist noch unklar. Die Zielsetzung dieser Doktorarbeit waren: i) die biogeographische Kartog

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6

Lindh, Jenny. "Identification of bacteria associated with malaria mosquitoes - Their characterisation and potential use." Doctoral thesis, Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6685.

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7

Ladner, Deborah Tillman. "Fitness of the transgenic malaria-refractory mosquito Anopheles gambiae." College Park, MD : University of Maryland, 2004. http://hdl.handle.net/1903/1991.

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Thesis (M.S.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Entomology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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8

Devenport, Martin Phillip. "Isolation and characterisation of genes regulating development in the mosquito Anopheles gambiae." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367172.

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9

Emami, Seyedeh Noushin. "The impact of erythrocyte density on the fitness of Anopheles gambiae mosquitoes and their capacity to transmit human malaria." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3724/.

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Anaemia is a common health problem affecting women and children in the developing world. This condition is characterized by a reduction in erythrocyte density, primarily resulting from malnutrition and/or infectious diseases such as malaria. As red blood cells are the most important source of protein for haematophagous mosquitoes, any reduction could impede the ability of mosquito vectors to transmit malaria by influencing their fitness and/or that of the parasites they transmit. The aim of this study was to determine the impact of differences in the density of red blood cells in human blood o

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10

Spiers, Susan. "Isolation and characterisation of eye colour genes and signal transduction genes in the mosquito, Anopheles gambiae." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240885.

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11

Nilsson, Louise. "Isolation of Thorsellia from Kenyan Anopheles gambiae sensu lato and their breeding waters." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-195963.

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Every year over two hundred million cases of malaria occur worldwide causing human death and suffering often in the poorest countries. Most people who die from malaria are children under five years of age. Malaria is caused by parasites spread by mosquitoes when they feed on human blood. Currently prevention methods include insecticides and anti-malarial drugs. The problem with both is the increasing resistance towards them by mosquitoes and parasites, respectively. Therefore other approaches need to be investigated to find new solutions to this problem. One such research area is paratransgene

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12

Stone, Christopher M. "Foraging Behavior and Reproductive Success of the Malaria Mosquito Anopheles gambiae s.s. (Diptera: Culicidae)." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312404297.

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13

Basu, Sanjay. "Site-directed integration of tissue-specific transgenes in the malaria vector mosquito Anopheles gambiae." Thesis, Keele University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505659.

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Malaria is the most prolific worldwide parasitic infection and is caused by a protozoan infection transmitted by Anopheles mosquitoes. The deadliest form of the disease is caused by Plasmodium falciparum for which the major vector in the endemic region of sub-Saharan Africa is Anopheles gambioe. Alongside vaccine research and drug development there are more novel approaches such as theoretical population replacement strategies employing transgenic mosquitoes. A key component in this strategy is the generation of mosquitoes carrying a transgene that can disrupt the parasite lifecycle and preven

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14

Ahmed, Ali Ashraf Mohamed. "A molecular approach to the effect of malaria infection on anopheline mosquito reproductive fitness." Thesis, Keele University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368978.

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15

Deaville, Pamela Jacqueline. "Apoptosis in the mosquito malaria vector Anopheles gambiae; development of an in vitro study system." Thesis, Keele University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572428.

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Malaria is a health problem for 40% of the world's population and is recognised as the world's major tropical disease, killing 4.7 million people annually. In the study of the disease to date apoptosis has been shown to be involved in the trade off relationships between parasite and mosquito host. Reduced fecundity in the infected mosquito has been postulated to be one such result of infection of the mosquito by the parasite that is beneficial to the parasite, in that it not only provides nutrients but results in increased biting rates and thus transmission of the parasite and as such is a tar

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16

Mutunga, James Mutuku. "Molecular, Biochemical, and Toxicological Evaluation of Anticholinesterases for control of the Malaria Mosquito, Anopheles gambiae." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/51210.

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Pyrethroids are the only class of insecticides approved by the World Health Organization (WHO) for use in insecticide treated nets (ITNs), the first line of malaria vector control. Widespread resistance development to pyrethroids undermines current control efforts, and hence an urgent need for alternative chemistries. I report the evaluation of pharmacological differences between insect and vertebrate acetylcholinesterase (AChE) as well as selectivity and toxicity testing of new carbamate insecticides on Anopheles gambiae, the African malaria mosquito. AChE gorge pharmacology data revealed dif

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17

Ekechukwu, Nkuru Esther. "The genetics and ecology of male reproductive investments in the malaria mosquito Anopheles gambiae s.s." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/2914/.

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Malaria continues to be a major global health problem due to high mortality and morbidity rate in endemic regions. An. gambiae s.s is the major vector in endemic African countries. About 198 million cases of malaria were recorded globally in 2013 and this have led to over 584 000 deaths. Different measures have been implemented in order to reduce and control the transmission rate. However, the drug resistant parasites and insecticide resistant mosquitoes have created problems towards achieving this goal. The use of the sterile insect technique and genetically modified mosquitoes as a control m

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18

SIMÕES, Maria Luísa. "Hemozoin as an immune stimulant of the mosquito Anopheles gambiae response against the malaria parasite." Doctoral thesis, Instituto de Higiene e Medicina Tropical, 2014. http://hdl.handle.net/10362/19197.

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Hemozoína, um metabolito produzido por Plasmodium spp., tem surgido como um potente estimulador, activando o sistema imunitário do hospedeiro e levando à produção de citocinas e quimiocinas em tecidos de mamíferos. Neste estudo, desvendamos o papel deste subproduto do parasita como estimulador da imunidade de Anopheles gambiae em resposta à infecção por Plasmodium berghei. A malária é uma doença infecciosa de distribuição mundial, causada por parasitas do género Plasmodium e transmitida pelas fêmeas de mosquitos do género Anopheles. A resposta imunitária do mosquito vector da malária contra o

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19

Akhouayri, Idir Georges. "Gene silencing of the kynurenine pathway and melanotic lesions in the malaria mosquito vector anopheles gambiae." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445336.

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20

Verma, Astha. "Small Core Heterocyclic Carbamates and Carboxamides: Resistance-breaking Acetylcholinesterase Inhibitors Targeting the Malaria Mosquito, Anopheles gambiae." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64294.

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Malaria is one of the deadliest diseases known to mankind. In 2010, 219 million cases were reported, and 666,000 deaths were attributed to this disease. In the past, pyrethroid-treated mosquito nets have shown efficacy in reducing malaria transmission in many malaria endemic regions. However, an upsurge in the mosquito population that is resistant to pyrethroids threatens to compromise the efficacy of pyrethroid-treated bed nets. In an effort to develop another class of insecticide with a different mode of action, we have explored three classes of five membered heterocyclic carbamates (isoxazo

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21

Fu, Xiaonan. "Functional study of miRNA-mRNA interactions in malaria mosquito An. gambiae." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96216.

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Female adults of many mosquito species possess distinct physiological features adapting to blood feeding for successful reproduction. The disease pathogens that are transmitted by mosquitoes have evolved to take advantages of the indispensable blood feedings to complete their transmission cycles and to survive attacks from the mosquito's innate immune system. Normal egg development and mosquito immunity are tightly controlled by tissue- and stage-specific gene expression and coordinated by many signal molecules in the mosquito. Understanding gene regulation affecting mosquito reproduction and

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22

Hartsel, Joshua Alan. "Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/73002.

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My graduate work focused on the syntheses and pharmacology of species-selective aryl methylcarbamate acetylcholinesterase inhibitors to combat the malaria-transmitting mosquito, Anopheles gambiae. We identified six novel carbamates that demonstrated levels of target selectivity exceeding our project milestone of 100-fold. Among the C2-substituted phenylcarbamates examined (class II), 2'-(2- ethylbutoxy)phenyl N-methylcarbamate (9bd*) was extraordinarily selective (570-fold + 72). The high level of selectivity observed for many of the class II carbamates was attributed to a helical displacement

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23

Baeshen, Rowaidh. "Effects of genetic and environmental factors on reproductive success in the malaria mosquito Anopheles gambiae Sensu Stricto." Thesis, Keele University, 2013. http://eprints.keele.ac.uk/604/.

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Anopheles gambiae is a major vector of malaria in sub-Saharan Africa. Given the widespread emergence of pesticide resistance in Anopheles gambiae populations, vector control programs involving the release of sterile males or genetically-modified male mosquitoes designed to diminish malaria transmission are eliciting renewed interest. The success of such mosquito release projects depends on the ability of released males to effectively mate and transfer sperm to wild females. Here, firstly we investigated the interactive effect of the environmental factor hydric stress and adult mosquito phenoty

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24

Rono, Evans Kiplangat [Verfasser], Elena A. [Gutachter] Levashina, Arturo [Gutachter] Zychlinski, and Susanne [Gutachter] Hartmann. "Variation in the Anopheles gambiae TEP1 Gene Shapes Local Population Structures of Malaria Mosquitoes / Evans Kiplangat Rono ; Gutachter: Elena A. Levashina, Arturo Zychlinski, Susanne Hartmann." Berlin : Humboldt-Universität zu Berlin, 2017. http://d-nb.info/1189328771/34.

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25

Okal, M. N. "Analysing the role of semiochemicals in the oviposition substrate choices of the malaria vector mosquito Anopheles gambiae sensu lato." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2015. http://researchonline.lshtm.ac.uk/2528132/.

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The search for tools that target malaria vector that resist insecticides and bite outdoors has become a research priority. Such tools will be necessary for managing residual malaria transmission and hastening the eradication of this devastating disease. This study investigated chemicals that potentially affect the oviposition substrate choices of Anopheles gambiae sensu lato (s.l.). It is foreseen that increased knowledge of the oviposition behaviour of this major malaria vectors and chemicals cues that mediate oviposition site-selection can be applied in the development of additional sampling

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26

Otienoburu, Philip E. "Plant Semiochemicals as Mosquito Attractants." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313605670.

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27

Henderson-Haefner, D. L. "Phage display antibodies to native and recombinant Anopheles gambiae midgut carboxypeptidase A : a potential anti-mosquito vaccine strategy for malaria endemic regions." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446600.

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Malaria is currently ranked as one of the most deadly human infectious diseases, causing an estimated three million deaths each year with half of these being children under the age of 5 years. Approximately 500 million people are currently infected with one or more species of <i>Plasmodium,</i> with 90% of the infections occurring in sub-Saharan Africa. In regions of the highest endemicity, a significant level of malaria transmission is vectored by the anthropophilic mosquito <i>An. gambiae sensu stricto</i> Giles. Using molecular techniques, native <i>An. gambiae s.s.</i> carboxypeptidase

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28

Mugumbate, Grace Chitima. "Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11737.

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Includes abstract.<br>Includes bibliographical references (leaves 183-184).<br>G-proton coupled receptors (GPCRs) are excellent drug targets that occupy a central position in the physiology of insects and are involved in transmission of signal from the extracellular to the intracellular side of the cell. Adipokinetic hormone receptors (AKHRs) are GPCRs that mediate physiological functions of the neurohormones, adipokinetic hormones (AKHs) that regulate mobilisation of energy reserves during mosquito flight. Ligand binding to GPCRs depends on the three dimensional (3D) structures of the recepto

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29

Zhang, Xin. "Characterization of chitin synthase and chitinase gene families from the African malaria mosquito." Diss., Kansas State University, 2010. http://hdl.handle.net/2097/6687.

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Doctor of Philosophy<br>Department of Entomology<br>Kun Yan Zhu<br>Chitin metabolism represents an attractive target site for combating insect pests as insect growth and development are strictly dependent on precisely toned chitin synthesis and degradation and this process is absent in humans and other vertebrates. However, current understanding on this process and the involved enzymes is rather limited in insects. In this study, two chitin synthase genes (AgCHS1 and AgCHS2 or AgCHSA and AgCHSB), and 20 chitinase and chitinase-like genes (groups I-VIII) presumably encoding the enzymes for chit

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30

Hsu, Danny Chung. "Mechanistic Studies on Memory of Chirality Alkylations of 1,4-Benzodiazepin-2-ones & Structure-based Design of Insecticidal AChE Inhibitors for Malaria Mosquito, Anopheles gambiae." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/29192.

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Memory of chirality (MOC) is an emerging strategy for asymmetric synthesis which relies upon the intermediacy of transiently non-racemic reactive species. In these reactions the configuration of the sole stereogenic center of the enantiopure starting material is "memorized" by a chiral non-racemic conformation in the intermediate; trapping then captures the stereochemical information, and generates a new stereogenic center with high fidelity. We experimentally and computationally studied the highly retentive deprotonation/alkylations of 1,4-benzodiazepin-2-ones (BZDs) that rely upon this strat

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31

Waldock, Joanna. "Anti-viral immunity in Anopheles gambiae mosquitoes." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6358.

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Mosquito transmitted viruses (arboviruses) cause significant burden in much of the developing world. Little is known about mosquito responses to viral infection, and how these responses could be utilised to prevent spread of viral disease. Anopheles gambiae, the principal vector of human malaria, unusually transmits virtually no arboviruses, with one known exception - O’nyony-nyong Virus (ONNV). In this thesis the interactions between ONNV and the A. gambiae immune system were studied. Initially ONNV infection in A. gambiae mosquitoes and an A. gambiae derived cell line were characterised. The

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32

Naujoks, Daniel. "Developing a gene targeting technology for Anopheles gambiae mosquitoes." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9864.

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Studying gene function in the human malaria vector Anopheles gambiae is the key to understanding its biology and vector-parasite interactions. Existing tools to study gene function do not include gene targeting, which would allow insights into gene function by permitting a range of specific modifications to any gene of choice. Based on developments in Drosophila (RONG and GOLIC 2000) this PhD project proposes to establish a method for gene targeting in Anopheles by homologous recombination, using a linear targeting construct generated in vivo. To this end, a transgenic strain was generated tha

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33

Paskins, Lynn. "Isolation of retrotransposons from Anopheles gambiae." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284251.

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34

Hawkes, Frances Madeline. "Host-seeking behaviour in the malaria vector Anopheles gambiae." Thesis, University of Greenwich, 2013. http://gala.gre.ac.uk/11378/.

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In sub-Saharan Africa, 90% of malaria cases are the result of transmission by the Anopheles gambiae species complex, causing 600,000 deaths annually. Increasingly, An. gambiae demonstrate behavioural and physiological resistance to control interventions and this, coupled with inadequate sampling methods, necessitates urgent development of new, efficient monitoring and control tools for malarial mosquitoes. The aim of this project was to examine the host-seeking behaviour of female An. gambiae to identify behavioural attributes that could be exploited in the design of novel trapping systems. To

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35

Donnelly, Martin James. "Population structure and gene flow in mosquitoes of the Anopheles gambiae complex." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365912.

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36

Turlove, Fanny Sophie. "NF-kappaB-mediated immunity in the malaria vector anopheles gambiae." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528287.

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37

Gulley, Melissa M. "Biochemical characterization of serpins in the malaria vector, Anopheles gambiae." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15870.

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Master of Science<br>Division of Biology<br>Kristin Michel<br>To date malaria is the most important tropical disease, which is caused by Plasmodium sp. and vectored by anopheline mosquitoes. The mosquito’s immune system is one of the limiting factors of malaria transmission. Immune reactions, such as the prophenoloxidase (PPO) pathway result in the melanization of pathogens, and are effective at limiting parasite numbers. Novel strategies for malaria control aim to exploit the immune system to interrupt parasite transmission by boosting the immune responses in the mosquito vector. Serpins pla

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38

Subramanian, Ramanand Arun. "The behavior and evolution of Class II transposable elements in the malarial mosquito, anopheles gambiae." College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8040.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2008.<br>Thesis research directed by: Dept. of Cell Biology and Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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39

Redmond, Seth. "Population structure and genome-wide association in the malaria vectors Anopheles gambiae and Anopheles coluzzii." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066085/document.

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Malgré le succès des insecticides pour le contrôle du paludisme, la transmission continue dans la plupart des pays d’Afrique sub-saharienne. La recherche pour de nouveaux moyens de contrôle (plus spécialement la modification génétique des populations vecteurs), ou l'utilisation plus efficace des contrôles actuels, vont nécessiter une recherche sur les structures de populations de moustiques et les processus d’immunisation qui importent pour la transmission du Plasmodium chez les moustiques sauvages. Par ailleurs, l’utilisation des techniques d’association génomique ‘GWAS’ est basée sur un réel

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40

Nikou, Dimitra. "Molecular analysis of multiple cytochrome P450s from the maleria vector Anopheles gambiae." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275044.

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41

Saddler, Adam. "Evaluating insecticide-resistance in the malaria vector Anopheles gambiae and its implications for malaria transmission." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24434.

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Insecticide resistance, in the mosquito vector, threatens the efficacy of current methods to control malaria. Yet evidence of control failure due to insecticide resistance is sparse, despite over 50 years since resistance was identified in the mosquito. In this thesis, laboratory experiments with mosquitoes, as well as mathematical modelling, are used to improve our understanding of how insecticide resistance might impact malaria transmission. Firstly, demographic and environmental effects on the phenotypic expression of resistance are investigated. Decreasing expression of resistance with age

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42

Vatandoost, Hassan. "The functional basis of pyrethroid resistance in the malaria vector, Anopheles stephensi." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318278.

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Quinones-Pinzon, Martha Lucia. "Effects of permethrin-impregnated bednets on Anopheles gambiae s.l. in the Gambia." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338870.

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44

Choi, Kwang Shik. "Genetic differentiation and introgression in malaria vectors of the Anopheles gambiae complex." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431729.

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45

Aboagye-Antwi, Fred. "Environmental stress and the fitness costs of plasmodium falciparum infection in the malaria mosquito anophele gambiae s.s." Thesis, Keele University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530781.

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46

Fernández, Medina Rita Daniela. "Elementos de transposición en el genoma de Anopheles gambiae." reponame:Repositório Institucional da FIOCRUZ, 2009. https://www.arca.fiocruz.br/handle/icict/2561.

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Made available in DSpace on 2011-05-04T12:42:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2009<br>Até hoje não existem mecanismos eficientes de controle da malaria, uma das doenças infecciosas mais importantes do mundo. Nas últimas décadas, a transformação genética dos mosquitos transmissores tem sido proposta como uma alternativa para o controle de esta doença. Para isso, além do desenvolvimento de técnicas para a introdução de DNA em células germinais dos mosquitos e da identificação de genes capazes de bloquear ou reduzir a transmissão de parasitas aos humanos, é necessário o de

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47

Scali, Christina Maria. "Re-mobilisation of a minos transposon in Anopheles stephensi mosquitoes and identification of the double sex gene in Anopheles gambiae." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424900.

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48

muel, Kweku Samuel Kweku. "Molecular and evolutionary genetics of Anopheles gambiae s.l, a malaria vector in Africa." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502575.

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One of the most important areas of research regarding adaptation of malaria vectors that has received very little attention is the effect of selection on the population structure of An. arabiellsis and the ecological significance of melanisation on the ability ofAn. gambiae to surVive in different habitats. Most microsatellite-based studies of population structure have selected loci that are located within inversions many of which may be subject to selection. The structure of the population will therefore depend on the nature of the selection on the selected loci and the effect of other nearby

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49

Bernardini, Federica. "A functional study of the Y chromosome in the malaria vector Anopheles gambiae." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/29878.

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Despite its function in sex determination and its role in driving genome evolution, the Y chromosome remains poorly understood in most species. Y chromosomes are gene-poor, repeat-rich and largely heterochromatic and therefore represent a difficult target for genetic engineering. The Y chromosome of the human malaria vector Anopheles gambiae appears to be involved in sex determination although very little is known about both its structure and function. The work described in this thesis led to the characterization of an Anopheles gambiae transgenic strain obtained by transposase-mediated integr

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Camerino, Eugene. "Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73771.

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Abstract:

Malaria continues to cause significant mortality in sub-Saharan Africa and elsewhere, and existing vector control measures are being threatened by growing resistance to pyrethroid insecticides. With the goal of developing new human-safe, resistance-breaking insecticides we have explored several classes of acetylcholinesterase inhibitors. In vitro assay studies demonstrate that tri- and difluoromethyl ketones can potentially inhibit An. gambiae AChE (AgAChE). These compounds inhibit the enzyme by making a covalent adduct with the catalytic serine of AChE. Trifluoromethyl ketones however are

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