Relevant bibliographies by topics / Anti-cytotoxic effect

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Anti-cytotoxic effect'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Anti-cytotoxic effect"

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SOYOCAK, Ahu, Ayşe AK, and Ebru ÖNEM. "Anti-quorum sensing and cytotoxic activity of elemi essential oil." International Journal of Secondary Metabolite 9, no. 3 (2022): 258–67. http://dx.doi.org/10.21448/ijsm.1059886.

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Essential oils have several biological activities such as antimicrobial, antioxidant, proliferative, and anti-inflammatory. This study aimed identification of bioactive compounds found in Elemi essential oil (EO) and to determine the anti-quorum sensing and cytotoxic activities of EO. In this study, bioactive compounds of EO were analyzed using GC-MS, and the antibacterial activity of elemi was screened against Staphylococcus aureus ATCC 25923, Methicillin-Resistant Staphylococcus aureus ATCC 43300, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa PAO1. An
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Vidyalaksh, K. S., A. I. Charles Dorni ., and Hannah R. Vasanthi . "Anti-Mitotic and Cytotoxic Effect of Mussaenda queensirkit." Journal of Pharmacology and Toxicology 2, no. 7 (2007): 660–65. http://dx.doi.org/10.3923/jpt.2007.660.665.

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Kulinich, T. M., Ya Yu Kiseleva, A. M. Shishkin, et al. "Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells." Sechenov Medical Journal 15, no. 2 (2024): 36–47. http://dx.doi.org/10.47093/2218-7332.2024.15.2.36-47.

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Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures.Materials and methods. We performed an in vitro study on CA125-positive human ovarian cancer cells (OVCAR-3, OVKATE) and CA125 negative cells (breast cancer MCF 7, embryonic kidney HEK293). Cytotoxic effects on tumor cells were evaluated after 0, 4, 8 and 24 hours using the 3’-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and
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MOHD AMIN, INDAH, NUR BATRISYIA RUSLAN, ZULINDA AYU ZULKIPLI, NURUL AILI ZAKARIA, MOHD TAUFIQ MAT JALIL, and FARIZAN ARIS. "CYTOTOXIC EFFECT OF DILLAPIOLE ON HUMAN BREAST CANCER MCF-7 CELLS." Malaysian Applied Biology 51, no. 4 (2022): 29–35. http://dx.doi.org/10.55230/mabjournal.v51i4.08.

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Plant secondary metabolites and their derivatives play a significant role in anticancer drug therapy since they are effective against specific characteristics while reducing side effects. Dillapiole is a phenylpropanoid that holds several bioactivities like anti-fungal, anti-inflammatory, anti-leishmanial, and anti-cancer. This study aims to investigate the possible cytotoxic effect of dillapiole on human breast cancer, MCF-7 cells. Cells were cultured in complete RPMI media and incubated at standard culture conditions. After the cells reached 80% confluency, cells were treated with various co
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Muflikhasari, Haruma Anggraini, Riris Istighfari Jenie, Ratna Asmah Susidarti, and Edy Meiyanto. "Growth Inhibitory Property of Pentagamavunone-0 (PGV-0) on 4T1 Cells under Stress Condition : 2D and 3D Culture Model." Indonesian Journal of Cancer Chemoprevention 10, no. 3 (2019): 149. http://dx.doi.org/10.14499/indonesianjcanchemoprev10iss3pp149-158.

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Pentagamavunone-0 (PGV-0), one of the curcumin analogue, is reported to have a cytotoxic effect on various cancer cells. This study aimed to explore the growth inhibitory effects of PGV-0 against highly-metastatic breast cancer, 4T1 cells under stress condition covering 2D and 3D speroid cytotoxic, anti-migration, and suppression of MMP-9. PGV-0 showed cytotoxic effects on 2D and 3D 4T1 cells with IC50value of 49 μM and 26 μM, respectively. In addition, PGV-0 performed anti-migratory effect. The single treatment at 25 μM PGV-0 and 50 μM showed inhibitory effect on cell migration by 54% and 51%
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Vignesh, M., S. Rajeshkumar, Anitha Roy, and T. Lakshmi. "Preparation of Herbal Formulation of Stevia and Piper Longum and its Antiinflammatory and Cytotoxic Effect." Journal of Complementary Medicine Research 13, no. 2 (2022): 87. http://dx.doi.org/10.5455/jcmr.2022.13.02.17.

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AIM: The aim of the study was to prepare the herbal formulation of stevia and the piper longum nanoparticle and to evaluate its anti-inflammatory and cytotoxic effects. Materials and Methods: For the evaluation of antiinflammatory activity we used albumin denaturation assay and for the cytotoxic activity we used a brine shrimp lethality assay and evaluated the result according to the test results and the graph was made with the results Result : The nanoparticle of stevia and piper longum showed a marked anti inflammatory and cytotoxic activity with increased in their concentrations Conclusion:
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Nurrachma, Marsya Yonna, Gergorius Gena Maran, Nindya Budiana Putri, et al. "Fingerroot (Boesenbergia pandurata) Extract Inhibits Proliferation and Migration of 4T1 Metastatic Breast Cancer Cells." Indonesian Journal of Cancer Chemoprevention 11, no. 3 (2020): 103. http://dx.doi.org/10.14499/indonesianjcanchemoprev11iss3pp103-114.

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Fingerroot (Boesenbergia pandurata) is an Indonesian herb, with anti-proliferation and anti-migratory effects against several cancer cells. This study aims to investigate the anticancer property of Fingerroot Extract (FE) in combination with doxorubicin (Dox) against 4T1, a metastatic breast cancer cell lines. FE was prepared by 96% ethanol maceration and characterized by thin-layer chromatography analysis. FE was subjected to a cytotoxicity test with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay alone or in combination with 10 nM Dox against 4T1 cells. Cytotoxic ef
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Abdel-Massih, Roula, Venicia Hawach, and Marie-Anne Boujaoude. "The Cytotoxic and Anti-proliferative Activity of High Molecular Weight Pectin and Modified Citrus Pectin." Functional Foods in Health and Disease 6, no. 9 (2016): 587. http://dx.doi.org/10.31989/ffhd.v6i9.270.

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Background: Pectin is a heterogeneous polysaccharide mainly present in citrus fruits and has different biological activities.Objective: High molecular weight Citrus Pectin and modified citrus pectin (MCP) were tested for their cytotoxic, anti-proliferative, and anti-oxidant activity.Methods: The cytotoxicity of pectin was studied against HaCaT cell line (human keratinocyte cell line) using Trypan blue method and LDH-cytotoxicity assay. Anti-proliferative activity was assayed using a WST-1 proliferation kit. Antioxidant activity was determined using the DPPH scavenging assay.Results: MCP and Pe
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Al-Ghazali, Linda. "The Anti-Candida and the Cytotoxic Activity of Aloe Vera Gel Extracts." Journal of Scientific Research in Medical and Biological Sciences 3, no. 4 (2022): 1–9. http://dx.doi.org/10.47631/jsrmbs.v3i4.559.

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Purpose: The research paper studies the in vitro anti-candida activity and cytotoxic effects of Aloe vera (Linn) leaves extract against melanoma and normal cell lines. Subjects and Methods: The traditional Soxhlet apparatus was used to prepare the crude plant extract using organic solvents. The agar well diffusion method was used to explore the in vitro anti-candida, and the MTT assay was used to assess the cytotoxic activity. Results: With IC50 values of 250 g/ml and more than 1000 g/ml, respectively, crude extract demonstrated anti-Candida activity against Candida ((kefyr, glabrata, and albi
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Leeuwenberg, J. F., H. Spits, W. J. Tax, and P. J. Capel. "Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies." Journal of Immunology 134, no. 6 (1985): 3770–75. http://dx.doi.org/10.4049/jimmunol.134.6.3770.

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Abstract The effects of monoclonal anti-T3 antibodies on the effector phase of cytotoxic T lymphocytes (CTL) were studied with respect to antigen-specific and antigen-nonspecific lysis of different target cells. Anti-T3 antibodies inhibited the antigen-specific lysis by CTL generated in mixed lymphocyte cultures (MLC), but they concomitantly augmented the nonspecific killing of third-party cells such as the cell lines Daudi, Raji, and K562. This nonspecific cytotoxicity was induced by various anti-T3 antibodies, whereas antibodies reactive with other antigens expressed on the cytotoxic effecto
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Dissertations / Theses on the topic "Anti-cytotoxic effect"

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Wood, Timothy Paul. "Identification of key mechanism in the cytotoxic effect of two novel anti-cancer compounds on breast cancer cells." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/24532.

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Organometallic chemotherapeutic agents, many of which target DNA, have been shown to be effective in the treatment of cancer. With that said though, these compounds have a number of side affects such as nephrotoxicity. Two novel compounds, Ferrocene [ferrocenoyltrichloroacetone] and Rhodium-ferrocene [(1.5 cyclooctadiene)(1-ferrocenyl- 4,4,4-trichloro-1,3-butanedionate], synthesised by the research group of J Swarts (University of the Free State) were evaluated to determine their mechanism of action and their potential use as novel therapeutic agents. It is hypothesized, by merit of their chem
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Beltran, Oscar. "Investigation of the anti-mycobacterial and cytotoxic effect of three medicinal plants used in the traditional treatment of tuberculosis in northern Mexico and the southwest U.S." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2008. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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Peschel, Wieland. "Cannabis Extracts for medicinal use - chemical profiling and in vitro cytotoxic and anti-inflammatory effects." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510076.

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KRISHAN, SUKRITI. "Role of AMPK in the Cytotoxic Effects of Anti-Tumour Agent, Dp44mT, in Pancreatic Cancer." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21479.

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Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor, that maintains cellular energy homeostasis under stress. Due to its central role in regulating multiple metabolic mechanisms within the cell, AMPK dysregulation is associated with cancer. Furthermore, iron’s ability to participate in pathways involving the generation of energy, suggest that AMPK phosphorylation and subsequent downstream effects could be critical to completely understand the emerging role of iron in interconnecting metabolic mechanisms. Hence, this thesis aimed to examine the role of AMPK, in
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Philippe, Chloe. "Modulation de la voie HIPPO par un métabolite aux propriétés anti-tumorales : l'AICAR." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0454/document.

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L’AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) est un intermédiaire de la voie de biosynthèse des purines. A des concentrations importantes, ce métabolite a un effet cytotoxique sur les cellules cancéreuses aneuploïdes, c’est-à-dire contenant un nombre anormal de chromosome. Or,90% des tumeurs solides sont aneuploïdes. Les mécanismes responsables de cette cytotoxicité doivent donc être mieux étudiés pour une utilisation éventuelle en thérapie anti-cancéreuse.Dans la littérature, l’effet de l’AICAR est expliqué par son rôle mimétique de l’AMP sur l’AMPK.Cependant, certaines données de
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Belkacem, Mohamed Amine. "Identification chimique de métabolites secondaires de certains microorganismes, évaluation de leur effet dans les domaines pharmaceutiques et agronomiques." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30293/document.

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Au cours de ce travail de thèse intitulé " Identification chimique de métabolites secondaires de certains microorganismes, évaluation de leurs effets dans les domaines pharmaceutiques et agronomiques ", nous nous sommes intéressés à l'étude des effets des conditions de culture sur la production des composés organiques volatils microbiens à partir de deux souches bactériennes co-existantes dans le sol Français : Burkholderia sp. et Bacillus megaterium. A partir des différents extraits préparés, plus que cent composés ont été identifiés, comprenant les dicétopipérazines, les alcools, les composé
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Rath, Sebastian. "Anti-angiogenic effects of cytotoxic, microbial derived compounds - Evaluation of the tubulin inhibitor pretubulysin and its derivatives and characterization of the v-ATPase inhibitor concanamycin A." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149868.

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Kourjian, Georgio. "Effect of HIV antiretroviral drugs on antigen processing and epitope presentation by MHC-I to cytotoxic T cells." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ027/document.

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L’apprêtement antigénique par les protéases intracellulaires et la présentation des épitopes sont essentiels pour la reconnaissance des cellules infectées par les lymphocytes CD8+. Ici nous avons montré que certains inhibiteurs de la protéase de la VIH (IPs) modulent l’activité de la protéasome et aminopeptidase impliqué dans l’apprêtement antigénique endogène et l’activité cathepsins importante dans l’apprêtement croisée. Deux IPs agissent directement sur les cathepsins et leurs régulateurs en inhibant les activités kinase, NOX2 et en régulant le pH phagolysosomal. Les IPs ont changé la dégra
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Herrmann, Anders. "Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8283.

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Rath, Sebastian [Verfasser], and Stefan [Akademischer Betreuer] Zahler. "Anti-angiogenic effects of cytotoxic, microbial derived compounds - Evaluation of the tubulin inhibitor pretubulysin and its derivatives and characterization of the v-ATPase inhibitor concanamycin A / Sebastian Rath. Betreuer: Stefan Zahler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1027669530/34.

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Books on the topic "Anti-cytotoxic effect"

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Wahed, Ismaeel Abrahim. Testicular toxicity of standard and investigational anti-cancer drugs: Cytotoxic effects ofstandard and investigational anti-cancer drugs on the histology and physiology of the mouse testis. 1988.

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Book chapters on the topic "Anti-cytotoxic effect"

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Koren, E., F. Milotic, F. A. Neethling, and D. K. C. Cooper. "Neutralization of the Cytotoxic Effect of Anti-αGal Antibodies with Monoclonal Anti-idiotypic Antibodies." In Xenotransplantation. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60572-7_27.

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Thakor, Parth, Ramalingam B. Subramanian, Sampark S. Thakkar, and Vasudev R. Thakkar. "Cytotoxic, Apoptosis Inducing Effects and Anti-Cancerous Drug Candidature of Jasmonates." In Drug Development for Cancer and Diabetes. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429330490-10.

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Multhoff, G., E. A. Repasky, and Peter Vaupel. "Mild Hyperthermia Induced by Water-Filtered Infrared A Irradiation: A Potent Strategy to Foster Immune Recognition and Anti-Tumor Immune Responses in Superficial Cancers?" In Water-filtered Infrared A (wIRA) Irradiation. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92880-3_10.

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AbstractApart from a number of positive “physiological” effects such as an increase in local blood flow which results in an improved oxygen supply and a reversal of tumor hypoxia, a key hallmark of cancer growth which greatly impairs anti-tumor immune responses, hyperthermia (HT) also exerts beneficial effects on anti-cancer immunity. The water-filtered infrared A (wIRA) irradiation technique achieves tissue temperatures in the fever-range (tT = 39–41 °C) or mild hyperthermia levels (tT = 39–43 °C) up to tissue depths of ≈25 mm in tissues. At tissue temperatures of 39–43 °C, by fostering the r
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Turka, Laurence A., Charles B. Carpenter, Edmond J. Yunis, and Edgar L. Milford. "Differential Effects of an Anti-IL-2 Receptor Antibody on Cytotoxic and Suppressor Cells." In Immunobiology of HLA. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-39946-0_242.

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Görög, György, Gabriella Bátory, Tamás Laskay, and Gyözö G. Petrányi. "Effects of the Workshop Anti-T Cell Monoclonal Antibodies on Lymphocyte Proliferative and Cytotoxic Functions." In Leukocyte Typing II. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4613-8587-5_10.

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Kapu, Venkatesh, Vanita Noronha, Nandini Menon, Minit Shah, Shripad Banavali, and Kumar Prabhash. "Metronomic Chemotherapy and Low-Dose Immunotherapy: An Intriguing Story." In Critical Issues in Head and Neck Oncology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-84539-0_23.

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Abstract Current treatment protocols are not curative for some cancers, despite significant advancements in cancer research. To enhance the treatment of cancer, it is therefore crucial to investigate novel therapeutic targets and approaches. Metronomic chemotherapy (MCT) is novel and effective treatment approach for solid tumors and blood malignancies which entails the continuous administration of low-dose cytotoxic medications in contrast to conventional chemotherapy regimens. The main characteristics of MCT are: frequent, uninterrupted, dose-dense chemotherapy administration; use of a biolog
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Brix, Nikko, and Kirsten Lauber. "Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms and Resistance Mechanisms." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23175-9_2.

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AbstractImmune checkpoint inhibition has emerged as an integral part of the standard-of-care for head and neck squamous cell carcinoma (HNSCC) in recurrent and/or metastatic stages. Clinical responses are impressive but remain limited to a minority of patients. Primary resistance of never-responders is considered to derive from host- and tumor-specific characteristics, the latter comprising tumor immune checkpoint activity, immune contexture, tumor mutational burden, neo-antigen load, and others. Secondary resistance of initially responding patients in addition, appears to be driven predominan
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Chauhdary, Zunera, Muhammad Ajmal Shah, Malik Hassan Mehmood, et al. "Saponins in the Treatment of Gastrointestinal Tract Cancer." In Phytonutrients in the Treatment of Gastrointestinal Cancer. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815049633123010010.

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The natural glycosides with triterpenoid or spirostaneaglycones are the saponins, which are associated with a wide range of therapeutic activities, inclusive of gastrointestinal anticancer activities. To promote research and development of novel cytotoxic agents against GIT cancer, this chapter focused on the anticancer potentia l of the naturally occurring triterpenoid and steroidal saponins. The in vitro assays and in vivo studies authenticated the anticancer potential of these compounds through anti-angiogenic, anti-proliferative, anti-metastatic and anti-multidrug resistance activities. Th
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Rajput, Dhirajsingh S. "The Classical Ayurveda Anti-Cancer Formulations." In Cancer Medicine in an Ayurvedic Perspective: A Critical Overview. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123852123010010.

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Rasoushadhis are special Ayurveda pharmaceutical formulations prepared from metals, minerals, potent herbs, and animal products. These medicines are preferred for severe chronic illnesses which are difficult to cure and life-threatening. Cancer is one such disease that ancient seers of Ayurveda noted. Several Rasoushadhis with potential cytotoxic and cell growth inhibitor actions are recommended for cancer treatment. The present chapter aims to disseminate such formulations, the basis behind their activity, and relevant other formulations that Ayurveda practitioners use to manage Bhaishajya Ra
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Ceylan, Burhan. "A New HPLC-DAD Method for the Simultaneous Measurements of Glycyrrhizic Acid (GA) and Glabridin (GB) in Licorice (Glycyrrhiza glabra L.) Extract." In High-Performance Liquid Chromatography - New Advances and Applications [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1006964.

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Glycyrrhiza glabra L. (Licorice) is a plant with important applications in the fields of medicine, food and cosmetics due to the extracts obtained from its root and the chemicals contained in these extracts. Glycyrrhizic acid (GA), a saponin glycosid, is the main component that gives licorice its sweet taste. The ammonium salt of this compound is listed in the European Pharmacopeia and is the sweetest natural flavoring listed on the Food and Drug Administration (FDA). Its main known properties are its effective properties in the treatment of ulcers, bronchitis, sore throats, liver diseases and
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Conference papers on the topic "Anti-cytotoxic effect"

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Algahtani, Mohammad, Khalid Alhazzani, Thiagarajan Venkatesan, Ali Alaseem, Sivanesan Dhandayuthapani, and Appu Rathinavelu. "Abstract 185: Direct cytotoxic effect of a novel anti-angiogenic drug F16 towards U87MG glioblastoma cell line." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-185.

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Algahtani, Mohammad, Khalid Alhazzani, Thiagarajan Venkatesan, Ali Alaseem, Sivanesan Dhandayuthapani, and Appu Rathinavelu. "Abstract 185: Direct cytotoxic effect of a novel anti-angiogenic drug F16 towards U87MG glioblastoma cell line." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-185.

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Magiatis, P., A. Papakonstantinou, A. Rigakou, et al. "New methods of isolation of olive secoiridoids and systematic study of their anti-proliferative/cytotoxic effect on multiple cancer cell lines." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759265.

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S. rajab, Eslah. "Date Palm Pollen (Phoenix dactylifera L.) Supplementations: impact on the Fertility and Anti-Cancer Properties." In XII. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2024. https://doi.org/10.47832/minarcongress12-16.

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Infertility and cancer are a major public health challenge globally. Date palm pollen (DPP), the male reproductive cells of the palm tree's flowers, has a long-standing use as a nutritional supplement, especially as an aphrodisiac and fertility ameliorative. Recently, some studies have looked into its effect against some types of cancer. This study sought to assay the impact of DPP extract (DPPE) supplementation on the fertility of adult healthy male Swiss albino mice in vivo and to evaluate its cytotoxic effect against human rhabdomyosarcoma (RD) cancer cell line in vitro. Forty male mice wer
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Kacar, Sedat. "Acrylamide has cytotoxic, apoptotic and anti-proliferative effects on mouse fibroblast cells." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-40.

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Pishko, Gregory L., Morad Nasseri, Seymur Gahramanov, Leslie L. Muldoon, and Edward A. Neuwelt. "Blood-Tumor Barrier Normalization Effects on Cytotoxic Drug Delivery to Brain Tumors." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14648.

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The blood-brain barrier (BBB) restricts delivery of anti-cancer drugs to brain tumors, but the leaky neovasculature of the blood-tumor barrier (BTB) permits systemically delivered cytotoxic agents to reach the tumor. Anti-angiogenic therapies such as bevacizumab (BEV) have been shown to “normalize” brain tumor vasculature,1 but the impact on chemotherapy delivery remains unclear.2 The goal of this study was to use magnetic resonance imaging (MRI) to investigate the consequences of BTB normalization, via BEV, on temozolomide (TMZ) chemotherapy. Non-invasive MRI techniques were used to track the
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Gogoi, Radhika P., Jessica M. Castañeda-Gill, Raghu P. Metpally, et al. "Abstract 117: Anti-proliferative and cytotoxic effects of verteporfin in endometrial cancer cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-117.

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Toktas, U., A. Nalbantsoy, C. Durmuskahya, and H. Kayalar. "Cytotoxic and anti-inflammatory effects of Eryngium creticum Lam. growing in Izmir, Turkey." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608468.

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Čolović, Mirjana B., Jelena J. Žakula, Lela B. Korićanac, Nada Savić, Tatjana Parac-Vogt, and Danijela Z. Krstić. "THE INFLUENCE OF ASCORBATE ON ANTI-HUMAN MELANOMA ACTION OF A MONOLACUNARY WELLS-DAWSON NANOCLUSTER." In 17th International Conference on Fundamental and Applied Aspects of Physical Chemistry. Society of Physical Chemists of Serbia, 2024. https://doi.org/10.46793/phys.chem24ii.603c.

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The influence of L(+)-ascorbic acid sodium salt (ascorbate), as a widely used antioxidant, on the anti-human melanoma A375 activity of a monolacunary Wells-Dawson polyoxometalate (mono- WD), α2-K10P2W17O61.20H2O was assessed in this study. A375 cells were in vitro exposed to the selected concentrations of mono-WD (the concentration range of 0.001 – 1 mM), ascorbate (0.040 – 40 mM), and the mixtures of mono-WD and ascorbate in the ratio of 1:40, for 24 and 48 hours. Both mono-WD and ascorbate induced concentration- dependent cytotoxic effects on A375 tumour cells, for both exposure times. The c
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Čolović, Mirjana B., Jelena J. Žakula, Lela B. Korićanac, et al. "IN VITRO ANTI-TUMOR EFFECT OF Fe(III)-CONTAINING WELLS-DAWSON POLYANION AND ASCORBATE." In 8th Workshop Food and Drug Safety and Qualit. Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, 2024. http://dx.doi.org/10.46793/8fdsq.pc4mc.

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The cytotoxic effect of the mixture of Fe(III)-substituted monolacunary Wells-Dawson polyoxometalate (Fe-WD), K7[FeIII(α2-P2W17O61)(H2O)] and L(+)-ascorbic acid sodium salt (ascorbate) on cervical carcinoma HeLa cells was evaluated in this study. Exponentially growing HeLa cells were treated in vitro with Fe-WD (0.001 – 1 mM), forty times higher concentrations of ascorbate (0.040 – 40 mM), and Fe-WD/ascorbate mixtures (concentration ratio 1 : 40) for 24 h, at 37 °C. Fe-WD and ascorbate inhibited cell viability in a concentration-dependent manner with different potencies. IC50 values were deter
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Reports on the topic "Anti-cytotoxic effect"

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Sritularak, Boonchoo, Kittisak Likhitwitayawuid, Pithi Chanvorachote, and Varisa Pongrakhananon. Cytotoxic constituents from Dendrobium spp. : Final report. Chulalongkorn University, 2014. https://doi.org/10.58837/chula.res.2014.28.

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The MeOH extracts of Dendrobium pullchellum Roxb. Ex Lind1. And D. ellipsophyllum Tang & wang (Orchidaceae) showed significant cytotoxic activity against human lung cancer cells. Phytochemical study of the whole plant of D. pullchellum Roxb. Ex Lind1 led to the isolation of seven phenolic compounds, namely, chrysotobibenzyl, chrysotoxine, crepidatin, moscatilin, fimbriatone, (-) –shikimic acid and liriodendrin. The whole plant of D. ellipsophyllum Tang & wang yielded ten phenolic compounds indluding moscatilin, 5,7-dihydroxy-chromen-4-one, 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenan
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