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Journal articles on the topic 'Anti-oxidative effect'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

&NA;. "Valsartan + fluvastatin: additive anti-oxidative effect." Inpharma Weekly &NA;, no. 1356 (2002): 14. http://dx.doi.org/10.2165/00128413-200213560-00036.

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2

Masukawa, Tohru, Tadahiro Tetsumi, and Jun'ichi Katakawa. "Anti-oxidative effect of dialkyl-dithiocarbamates." Japanese Journal of Pharmacology 61 (1993): 275. http://dx.doi.org/10.1016/s0021-5198(19)51961-8.

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3

Yanai, Hidekatsu. "Anti-atherosclerotic effects of tomatoes." Functional Foods in Health and Disease 7, no. 6 (2017): 411. http://dx.doi.org/10.31989/ffhd.v7i6.351.

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Background: Tomatoes are rich in lycopene which is responsible for the red color seen in tomatoes. Several reports have suggested the role of lycopene in the prevention of cardiovascular diseases. Here, we systematically reviewed the interventional studies using tomatoes or tomato products, to understand anti-atherosclerotic effects of tomato as a functional food. We found that relatively great number of interventional studies reported anti-atherosclerotic effects of tomatoes such as anti-obesity effect, hypotensive effect, improvement of lipid/glucose metabolism and endothelial function, anti

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4

Kim, You Jung, Ki Sung Kang, and Takako Yokozawa. "The anti-melanogenic effect of pycnogenol by its anti-oxidative actions." Food and Chemical Toxicology 46, no. 7 (2008): 2466–71. http://dx.doi.org/10.1016/j.fct.2008.04.002.

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Lilia, Boussouf, Boutennoun Hanane, Adjeroud Nawel, Boulekbache-Makhlouf Lila, and Madani Khodir. "PROTECTIVE EFFECT OF ALGERIAN SALVIA VERBENACA EXTRACT AGAINST INFLAMMATION AND OXIDATIVE STRESS." Journal of Applied Biological Sciences 17, no. 1 (2023): 1–19. https://doi.org/10.5281/zenodo.7579538.

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This study aims to examine the anti-inflammatory and antioxidant effects of polyphenolic extract of <em>Salvia verbenaca</em> L. using <em>in vivo</em> and <em>in</em> <em>vitro</em> models. The <em>in vivo </em>anti-inflammatory activity was evaluated using carrageenan-induced mice paw edema method. The <em>in vivo</em> antioxidant effect of the extract was explored by measuring oxidative stress (MDA, CAT, GSH and SOD) parameters. The <em>in vitro</em> anti-inflammatory activity was performed using protein denaturation and membrane stabilization assays. DPPH and hydrogen peroxide tests were u

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Kao, Chien-Jen, Hsin-Yu Chou, Yu-Chen Lin, Qinghong Liu, and Hui-Min David Wang. "Functional Analysis of Macromolecular Polysaccharides: Whitening, Moisturizing, Anti-Oxidant, and Cell Proliferation." Antioxidants 8, no. 11 (2019): 533. http://dx.doi.org/10.3390/antiox8110533.

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In this research we utilized extracts from two different nature products, Achatina fulica and Heimiella retispora, to enhance skin moisturizing abilities, anti-oxidative properties, and cell proliferations. It was observed that two polysaccharides with anti-oxidative effects by chelating metal ions reduced oxidative stress and further blocked the formation of reactive oxygen species syntheses. To detect whether there was a similar effect within the cellular mechanism, a flow cytometry was applied for sensing the oxidative level and it was found that both materials inhibited the endogenous oxid

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He, Bin, Qian Zeng, Yumei Tian, et al. "PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence." Biomedicines 12, no. 7 (2024): 1436. http://dx.doi.org/10.3390/biomedicines12071436.

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease for which there is a lack of effective pharmacological treatments. Hirudin, a natural peptide extracted from leeches, has been used for broad pharmacological purposes. In this study, we investigated the therapeutic effects of hirudin on IPF and its related mechanism of action. By constructing a mouse model of pulmonary fibrosis and treating it with hirudin in vivo, we found that hirudin exerted anti-fibrotic, anti-oxidative, and anti-fibroblast senescence effects. Moreover, using an in vitro model of stress-ind

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8

SANTHOSH G, NITHISHWAR M, and FATHIMA BASHEERA M. "Benign outcomes of metformin for various diseases: A review." World Journal of Advanced Research and Reviews 20, no. 1 (2023): 278–86. http://dx.doi.org/10.30574/wjarr.2023.20.1.2036.

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Metformin is the most popularly prescribed first-line drug in the management of type 2 diabetes mellitus. Metformin exerts different effects such as anti- hyperglycemic effect, analgesic effect in the management of musculoskeletal pain and anti-depressant effect in depression management, cardio protective and neuroprotective effects in the cardiovascular system and central nervous system. Nrf2 is the factor responsible for enhancing the anti-oxidative effects of metformin. Metformin exerts its anti-proliferative effect through the suppression of tumor development and modifies the surroundings

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SANTHOSH, G., M. NITHISHWAR, and BASHEERA M. FATHIMA. "Benign outcomes of metformin for various diseases: A review." World Journal of Advanced Research and Reviews 20, no. 1 (2023): 278–86. https://doi.org/10.5281/zenodo.12177058.

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Metformin is the most popularly prescribed first-line drug in the management of type 2 diabetes mellitus. Metformin exerts different effects such as anti- hyperglycemic effect, analgesic effect in the management of musculoskeletal pain and anti-depressant effect in depression management, cardio protective and neuroprotective effects in the cardiovascular system and central nervous system. Nrf2 is the factor responsible for enhancing the anti-oxidative effects of metformin. Metformin exerts its anti-proliferative effect through the suppression of tumor development and modifies the surroundings

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10

Samadarsi, Rohini, and Debjani Dutta. "Anti-oxidative effect of mangiferin-chitosan nanoparticles on oxidative stress-induced renal cells." International Journal of Biological Macromolecules 151 (May 2020): 36–46. http://dx.doi.org/10.1016/j.ijbiomac.2020.02.112.

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11

Fatima, Mahejabeen, and Syed Ibrahim Rizvi. "Anti Oxidative Effect of Black Tea Theaflavin on Erythrocytes Subjected to Oxidative Stress." National Academy Science Letters 38, no. 1 (2014): 25–28. http://dx.doi.org/10.1007/s40009-014-0285-9.

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12

Choi, Sang Yoon, and Kyung-Tack Kim. "Anti-oxidative and muscle cell protective effects of ginger extract according to the extraction conditions." Korean Journal of Food Preservation 29, no. 5 (2022): 762–67. http://dx.doi.org/10.11002/kjfp.2022.29.5.762.

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Ginger (Zingiber officinale Rosc.) root is known to have anti-oxidative effects. However, studies on the extraction conditions to obtain ginger extract (GE) with high antioxidant power have not yielded satisfactory results. Therefore, the effects of extraction temperature and time on the anti-oxidative effects of GE were investigated. The content of 6-gingerol and 6-shogaol in the GE was also analyzed. The results revealed that extraction carried out at 50°C for 5 h was optimal for maintaining the anti-oxidative activity of the GE. Further, GE obtained under these optimal conditions exhibited

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13

Sharma, Harsha, Ankita Joshi, Harsha Lad, and Deepak Bhatnagar. "ANTI-OXIDATIVE, ANTI-INFLAMMATORY AND ANTI-ATHEROSCLEROTIC EFFECT OF TAURINE ON HYPERCHOLESTEROLEMIA INDUCED ATHEROSCLEROTIC RATS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 3 (2018): 145. http://dx.doi.org/10.22159/ijpps.2018v10i3.24372.

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Objective: The present study evaluates the antioxidant, anti-inflammatory and anti-atherosclerotic potency of taurine (2-amino ethane sulfonic acid) when administered orally to hypercholesterolemia induced atherosclerotic rats.Methods: The experimental atherosclerosis was induced by feeding rats with an atherogenic diet comprising of the normal rat chow supplemented with 4 % cholesterol, 1 % cholic acid and 0.5 % thiouracil (CCT diet) for 20 d. Treatment with atorvastatin (10 mg/kg body weight) and taurine (2 % in drinking water) was given to atherosclerotic rats to study antioxidant enzymes (

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14

Kim, Suhn, and Hyeyoung Kim. "Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review." Nutrients 10, no. 9 (2018): 1137. http://dx.doi.org/10.3390/nu10091137.

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Oxidative stress is a major contributor to the pathogenesis of various human diseases as well as to the aging process. Mitochondria, as the center of cellular metabolism and major regulators of redox balance, play a critical role in disease development and progression. Mitochondrial dysfunction involving structural and metabolic impairment is prominent in oxidative stress-related diseases. Increased oxidative stress can damage mitochondria, and subsequent mitochondrial dysfunction generates excesses of mitochondrial reactive oxygen species that cause cellular damage. Mitochondrial dysfunction

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15

Alvarez-Arellano, Lourdes, Marcela Salazar-García, and Juan Carlos Corona. "Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases." Molecules 25, no. 23 (2020): 5597. http://dx.doi.org/10.3390/molecules25235597.

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Oxidative stress is a crucial event underlying several pediatric neurological diseases, such as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Neuroprotective therapy with natural compounds used as antioxidants has the potential to delay, ameliorate or prevent several pediatric neurological diseases. The present review provides an overview of the most recent research outcomes following quercetin treatment for CNS tumors, ASD and ADHD as well as describes the potential in vitro and in vivo ameliorative effect on oxida

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Oviosun, Augustine, Anyanwu Godson Emeka, Ezinne Chidinma Oviosun, and Okwara Blasius Okechukwu. "Ameliorative effect of zingerone on cadmium-induced nephrotoxicity in adult wistar rats." International Journal of Plant Based Pharmaceuticals 4, no. 2 (2024): 118–24. https://doi.org/10.62313/ijpbp.2024.238.

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Exposure to heavy metals like cadmium has been reported to cause severe kidney damage through oxidative stress and inflammation. Zingerone is a bioactive compound present in ginger, it contains significant anti-oxidative and anti-inflammatory properties. This study aims to investigate the anti-oxidative and therapeutic role of zingerone on cadmium-induced nephrotoxicity. Thirty (30) adult male rats were divided into 6 groups (A-F) of 5 rats each (n = 5) randomly [A: normal control (normal saline), B: cadmium-exposed (5 mg/kg of cadmium only), C: zingerone-alone, D-F: 5 mg/kg of cadmium + 50 mg

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17

Shi, Jianan, Xiufang Peng, Junyi Huang, Mengyi Zhang, and Yuqin Wang. "Dihydromyricetin Alleviated Acetaminophen-Induced Acute Kidney Injury via Nrf2-Dependent Anti-Oxidative and Anti-Inflammatory Effects." International Journal of Molecular Sciences 26, no. 5 (2025): 2365. https://doi.org/10.3390/ijms26052365.

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Acute kidney injury (AKI) is a common side effect of acetaminophen (APAP) overdose. Dihydromyricetin (DHM) is the most abundant flavonoid in rattan tea, which has a wide range of pharmacological effects. In the current study, APAP-induced AKI models were established both in vivo and in vitro. The results showed that DHM pretreatment remarkably alleviated APAP-induced AKI by promoting antioxidant capacity through the nuclear factor erythroid-related factor 2 (Nrf2) signaling pathway in vivo. In addition, DHM reduced ROS production and mitochondrial dysfunction, thereby alleviating APAP-induced

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18

Nankar, Sunil A., Yogesh Bulani, Shyam S. Sharma, and Abhay H. Pande. "ApoE-Derived Peptides Attenuated Diabetes-Induced Oxidative Stress and Inflammation." Protein & Peptide Letters 27, no. 3 (2020): 193–200. http://dx.doi.org/10.2174/0929866526666191002112655.

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Background: Peptides derived from the apolipoproteins (apo-mimetic peptides) have emerged as a potential candidate for the treatment of various inflammatory conditions. Our previous results have shown that peptides derived from human apolipoprotein-E interact with various pro-inflammatory lipids and inhibit their inflammatory functions in cellular assays. Objective: In this study, two apoE-derived peptides were selected to investigate their antiinflammatory and anti-oxidative effects in streptozotocin-induced diabetic model of inflammation and oxidative stress. Methods: The peptides were injec

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19

Sun, Ying, Yu Lu, Christopher G. Engeland, Sara C. Gordon, and Herve Y. Sroussi. "The anti-oxidative, anti-inflammatory, and protective effect of S100A8 in endotoxemic mice." Molecular Immunology 53, no. 4 (2013): 443–49. http://dx.doi.org/10.1016/j.molimm.2012.10.002.

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20

PÂRVU, Alina Elena, Florinela CĂTOI, Sameera DEELAWAR, Darshana SARUP, and Marcel PÂRVU. "Anti-Inflammatory Effect of Allium ursinum." Notulae Scientia Biologicae 6, no. 1 (2014): 20–26. http://dx.doi.org/10.15835/nsb619252.

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The aim of the present study was to evaluate Allium ursinum leaves and flowers extract anti-inflammatory effect. Plant extract 1:1 (w:v) was prepared from A. ursinum leaves by a modified Squibb repercolation method. The in vivo anti-inflammatory effects were evaluated on a rat turpentine oil-induced inflammation (i.m. 6 mL/kg BW). The animals were randomly assigned to nine groups (n=8): negative control, inflammation, A. ursinum flower extract (AUF), A. ursinum leaves extract (AUL), indomethacin (INDO) (20 mg/kg BW), aminoguanidine (AG) (50 mg/kg b.w./d i.p.) as a selective NOS2 inhibitor, NG-

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21

Hong, Chong, Xu Wang, Jianjian Xu, Jianxing Guo, Houlin Peng, and Yan Zhang. "A Review: Pharmacological Effect of Natural Compounds in Diospyros kaki Leaves from the Perspective of Oxidative Stress." Molecules 29, no. 1 (2023): 215. http://dx.doi.org/10.3390/molecules29010215.

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Oxidative stress is caused by an imbalance between reactive oxygen species and antioxidant levels. Current research suggests that oxidative stress is one of the key factors in the development of many chronic diseases, and it has been a concern for many years. Many natural compounds have been studied for their special free-radical-scavenging properties. The major chemical constituents of the leaves of Diospyros kaki are flavonoids and triterpenoids, both of which are potential antioxidants that can prevent damage caused by reactive oxygen species or reactive nitrogen species and ameliorate dise

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Liu, Run-Ze, Wen-Jun Li, Juan-Juan Zhang, et al. "The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro." Marine Drugs 20, no. 11 (2022): 696. http://dx.doi.org/10.3390/md20110696.

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Phycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead to the induction of heme oxygenase 1 expression in vivo, thus achieving antioxidant and anti-inflammatory effects. Phycocyanin is bound internally with linear tetrapyrrole phycocyanobilin in a similar structure to bilirubin. We speculate that there is probably a way of inducing the expression of heme oxygenase 1, with which tissue oxidative stress and inflammation can be

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Wang, Shanshan, Qian Luo, and Peihong Fan. "Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator." International Journal of Molecular Sciences 20, no. 3 (2019): 507. http://dx.doi.org/10.3390/ijms20030507.

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Hemp seed (Fructus cannabis) is rich in lignanamides, and initial biological screening tests showed their potential anti-inflammatory and anti-oxidative capacity. This study investigated the possible effects and underlying mechanism of cannabisin F, a hempseed lignanamide, against inflammatory response and oxidative stress in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Cannabisin F suppressed the production and the mRNA levels of pro-inflammatory mediators such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in a concentration-dependent manner in LPS-stimulated BV2 mic

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Singh, Prabhakar, and Syed Ibrahim Rizvi. "Anti-Oxidative Effect of Curcumin Against Tert-Butylhydroperoxide Induced Oxidative Stress in Human Erythrocytes." Natural Products Journale 2, no. 1 (2012): 69–73. http://dx.doi.org/10.2174/2210315511202010069.

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25

Lanzarin, Germano A. B., Luís M. Félix, Sandra M. Monteiro, Jorge M. Ferreira, Paula A. Oliveira, and Carlos Venâncio. "Anti-Inflammatory, Anti-Oxidative and Anti-Apoptotic Effects of Thymol and 24-Epibrassinolide in Zebrafish Larvae." Antioxidants 12, no. 6 (2023): 1297. http://dx.doi.org/10.3390/antiox12061297.

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Thymol (THY) and 24-epibrassinolide (24-EPI) are two examples of plant-based products with promising therapeutic effects. In this study, we investigated the anti-inflammatory, antioxidant and anti-apoptotic effects of the THY and 24-EPI. We used zebrafish (Danio rerio) larvae transgenic line (Tg(mpxGFP)i114) to evaluate the recruitment of neutrophils as an inflammatory marker to the site of injury after tail fin amputation. In another experiment, wild-type AB larvae were exposed to a well known pro-inflammatory substance, copper (CuSO4), and then exposed for 4 h to THY, 24-EPI or diclofenac (D

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Jadhav, Ratnakar, and Yogesh A. Kulkarni. "Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats." Molecules 28, no. 1 (2023): 417. http://dx.doi.org/10.3390/molecules28010417.

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Recent evidences indicate that there is a substantial increase in worldwide cases of dementia. Alzheimer’s disease is the leading cause of dementia and may contribute to 60–70% of cases. Quercetin is a unique bioflavonoid that has numerous therapeutic benefits such as anti-allergy, anti-ulcer, anti-inflammatory, anti-hypertensive, anti-cancer, immuno-modulatory, anti-infective, antioxidant, acetylcholinesterase inhibitory activity, neuroprotective effects, etc. In the present study, we evaluated the neuroprotective effect of orally administered quercetin with memantine in albino Wistar rats af

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Davydov, A. I., M. B. Khabarova, R. I. Chilova, V. A. Lebedev, and M. N. Shakhlamova. "Endometriosis and oxidative stress. Treatment rationale in endometriosis-associated infertility." Voprosy ginekologii, akušerstva i perinatologii 22, no. 1 (2023): 69–75. http://dx.doi.org/10.20953/1726-1678-2023-1-69-75.

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Oxidative stress, which reflects an imbalance between the manifestations of reactive oxygen species in the body and a biological system’s ability to readily detoxify the reactive intermediates, is of considerable importance among the mechanisms of endometriosis development. Disturbances in the redox state of cells can lead to toxic effects through the production of peroxides and free radicals. The data presented in this review indicate the necessity to include antioxidant agents capable of suppressing several important manifestations of oxidative stress in the complex of treatment measures for

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Eckert, Denise, Felicitas Rapp, Ayele T. Tsedeke, et al. "ROS- and Radiation Source-Dependent Modulation of Leukocyte Adhesion to Primary Microvascular Endothelial Cells." Cells 11, no. 1 (2021): 72. http://dx.doi.org/10.3390/cells11010072.

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Anti-inflammatory effects of low-dose irradiation often follow a non-linear dose–effect relationship. These characteristics were also described for the modulation of leukocyte adhesion to endothelial cells. Previous results further revealed a contribution of reactive oxygen species (ROS) and anti-oxidative factors to a reduced leukocyte adhesion. Here, we evaluated the expression of anti-oxidative enzymes and the transcription factor Nrf2 (Nuclear factor-erythroid-2-related factor 2), intracellular ROS content, and leukocyte adhesion in primary human microvascular endothelial cells (HMVEC) upo

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Finocchiaro, Concetta, Olivia Segre, Maurizio Fadda, et al. "Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study." British Journal of Nutrition 108, no. 2 (2011): 327–33. http://dx.doi.org/10.1017/s0007114511005551.

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PUFA from fish oil appear to have anti-inflammatory and anti-oxidative effects and improve nutritional status in cancer patients. With this as background, the aim of the present study was to investigate the effect of EPA plus DHA on inflammatory condition, and oxidative and nutritional status in patients with lung cancer. In our multicentre, randomised, double-blind trial, thirty-three patients with a diagnosis of advanced inoperable non-small-cell lung cancer and undergoing chemotherapy were divided into two groups, receiving four capsules/d containing 510 mg of EPA and 340 mg of DHA, or 850

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Cho, Young-Chang, Jiyoung Park, and Sayeon Cho. "Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation." International Journal of Molecular Sciences 21, no. 6 (2020): 2007. http://dx.doi.org/10.3390/ijms21062007.

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Various herbal extracts containing luteolin-7-O-glucuronide (L7Gn) have been traditionally used to treat inflammatory diseases. However, systemic studies aimed at elucidating the anti-inflammatory and anti-oxidative mechanisms of L7Gn in macrophages are insufficient. Herein, the anti-inflammatory and anti-oxidative effects of L7Gn and their underlying mechanisms of action in macrophages were explored. L7Gn inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages by transcriptional regulation of inducible NO synthase (iNOS) in a dose-dependent manner.

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Yang, Che-Hsueh, Yen-Chuan Ou, Chi-Chien Lin, et al. "Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review." Life 12, no. 7 (2022): 1029. http://dx.doi.org/10.3390/life12071029.

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Currently, medication for benign prostate hyperplasia (BPH) and prostate cancer (PCa) are mainly based on modulating the hormone and nervous systems. However, side effects often affect patients, and might decrease their commitment to continuing the medication and lower their quality of life. Some studies have indicated that chronic inflammation might be the cause of BPH and PCa. Based on this hypothesis, the effect of phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, has been researched since 2010. Results from animal and in-vitro studies, obtained from databases, also indica

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Miazek, Krystian, Karolina Beton, Agnieszka Śliwińska та Beata Brożek-Płuska. "The Effect of β-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used". Biomolecules 12, № 8 (2022): 1087. http://dx.doi.org/10.3390/biom12081087.

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Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and functioning, and is associated with the development of numerous disorders. Naturally occurred anti-oxidant compounds reduce the oxidative stress in living organisms. In this review, antioxidant properties of β-carotene, tocopherols and ascorbic acid are presented based on in vitro, in vivo and populational studies. Firstly, environmental factors contributing to the OS occurrence and intracellular sources of Reactive Oxygen Species (ROS) generation, as well as ROS-mediated cellular structure degradation, ar

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Kondo, Tomomi, Akiko Nakashima, Tomoko Watanabe, et al. "Studies on the Anti-oxidative Stress Effect of Shiitake Mushroom." Nippon Shokuhin Kagaku Kogaku Kaishi 63, no. 5 (2016): 199–208. http://dx.doi.org/10.3136/nskkk.63.199.

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Park, Dong-Ju, Ju-Bin Kang, and Phil-Ok Koh. "Anti-oxidative effect of baicalin in lipopolysaccharide-induced hippocampus damage." Journal of the Preventive Veterinary Medicine 44, no. 3 (2020): 118–23. http://dx.doi.org/10.13041/jpvm.2020.44.3.118.

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Shinohara, Yuta, Tatsuya Usui, and Kazuaki Sasaki. "Possible Anti-Oxidative Effect of Juzen-taiho-to in Dogs." Proceedings for Annual Meeting of The Japanese Pharmacological Society 92 (2019): 2—O—50. http://dx.doi.org/10.1254/jpssuppl.92.0_2-o-50.

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36

Bao, Qi, Zihan Wang, Tingting Yang, et al. "Curcumin induces mitochondrial dysfunction-associated oxidative DNA damage in ovarian cancer cells." PLOS ONE 20, no. 3 (2025): e0319846. https://doi.org/10.1371/journal.pone.0319846.

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Resistance to chemotherapeutic agents is a critical challenge for the clinical management of ovarian cancer. While curcumin has been reported to possess anti-cancer properties, how it exerts its anti-neoplastic effect on ovarian cancer cells remains to be explored. We here characterized the fate of human ovarian cancer cell lines HO8910 and OVCAR3 treated with curcumin. Cell proliferation, cell death, mitochondrial function, oxidative damage and tumor formation in nude mice were examined. Significant inhibition of proliferation and induction of apoptosis were observed in ovarian cells treated

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Srivastava, Anup K., Subhasree Roy Choudhury, and Surajit Karmakar. "Melatonin/polydopamine nanostructures for collective neuroprotection-based Parkinson's disease therapy." Biomaterials Science 8, no. 5 (2020): 1345–63. http://dx.doi.org/10.1039/c9bm01602c.

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The bioinspired melatonin/polydopamine nanostructures confer superior neuroprotection in dopaminergic neurons via anti-oxidative, anti-inflammatory and anti-apoptotic effect in Parkinson's disease models.

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38

Qu, Hengxian, Longfei Zhang, Xiaoxiao Liu, et al. "Modulatory Effect of Limosilactobacillus fermentum grx08 on the Anti-Oxidative Stress Capacity of Liver, Heart, and Kidney in High-Fat Diet Rats." Fermentation 8, no. 11 (2022): 594. http://dx.doi.org/10.3390/fermentation8110594.

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To explore the modulating effect of Limosilactobacillus fermentum (L. fermentum) grx08 on anti-oxidative stress in the liver, heart, and kidney of high-fat diet in rats, a low-fat diet as a control and a high-fat diet was used to induce oxidative stress injury in rats. L. fermentum grx08 and its heat-inactivated bacteria were used to intervene. The results showed that the high-fat diet had caused oxidative stress injury in the liver, heart, and kidney of rats. L. fermentum grx08 significantly reduced the serum levels of liver, heart, and kidney injury markers (ALT, AST, LDH, CK-MB, UA, and Cre

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Choudhary, Neha, Narinder Singh, Ajeet Pal Singh, and Amar Pal Singh. "Medicinal Uses of Maslinic Acid: A Review." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 237–40. http://dx.doi.org/10.22270/jddt.v11i2.4588.

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Maslinic Acid a characteristic compound of the triterpenoid bunch got from olive which forestalls the age of favorable to fiery cytokines and oxidative pressure, found in an assortment of common sources, going from home grown cures utilized in traditional medicine to consumable vegetables and organic products present in the Mediterranean eating routine. A few investigations have demonstrated that maslinic acid a wide scope of pharmacological effects such as Antimalarial Effect, Anti-Proliferative Activity, Antitumor Activity, Antifungal Activity, Antibacterial Activity, Anti-diabetic Effect, A

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Savaş, Hasan Basri, Mehmet Enes Sözen, and Elina Dinç. "The effect of tartrazine on angiogenesis and oxidative stress in the chorioallantoic membrane model." Biotech Studies 34, no. 1 (2025): 22–34. https://doi.org/10.38042/biotechstudies.1620369.

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Tartrazine is commonly preferred as a coloring agent in non-alcoholic beverages, fruit juices, jellies, cereals, and soups. This study aims to investigate the effects of tartrazine exposure on anti-angiogenesis and the oxidant-antioxidant balance. Three different tartrazine dose, a bevacizumab, and an empty pellet used to evaluate anti-angiogenic effects on the chorioallantoic membrane (CAM) model. Fluid samples were collected for measurements of total antioxidant capacity (TAC) and total oxidant status (TOS), from which the oxidative stress index (OSI) was calculated. The control group and 10

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Jeong, Hyeon Soo, Seung Eun Lee, Jin Tae Jeong, et al. "Comparison of Anti-oxidative and Anti-inflammatory Effect of Atractylodes Interspecific Hybrid Cultivar Roots." Korean Journal of Medicinal Crop Science 26, no. 5 (2018): 391–400. http://dx.doi.org/10.7783/kjmcs.2018.26.5.391.

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Han, Kyungsun, Jinghwa Wang, Dongwoo Lim, et al. "Anti-Oxidative and Anti-Obesity Effect of Combined Extract and Individual Extract of Samjunghwan." Journal of Korean Medicine for Obesity Research 14, no. 02 (2014): 47–54. http://dx.doi.org/10.15429/jkomor.2014.14.2.47.

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Kim, Jeong Mi, Dae Jung Kim, Tae Hyuk Kim, Hyun Sook Kim, and Myeon Choe. "Anti-Oxidative and Anti-Inflammatory Effect of Water Extract fromPerillae semenin RBL-2H3 Cells." Korean Journal of Nutrition 43, no. 4 (2010): 367. http://dx.doi.org/10.4163/kjn.2010.43.4.367.

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Ji, Joong-Gu. "Anti-Oxidative and Anti-inflammatory Effect of Combined Extract and Individual Extract of GamiSaengmaeksan." Korea Journal of Herbology 31, no. 1 (2016): 69–75. http://dx.doi.org/10.6116/kjh.2016.31.1.69.

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Nishikawa, Hirofumi, Jinsyo Tsutsumi, and Seiichi Kitani. "Anti-inflammatory and anti-oxidative effect of curcumin in connective tissue type mast cell." Journal of Functional Foods 5, no. 2 (2013): 763–72. http://dx.doi.org/10.1016/j.jff.2013.01.022.

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Pal, Dibya, Sajani Singha Roy, Shibani Das, and Debidas Ghosh. "Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach." Indian Journal of Biological Sciences 27 (June 2021): 30–38. http://dx.doi.org/10.62424/ijbs.2021.27.01.02.

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Medicinal plants are utilized in various formulations to treat a wide range of illnesses, includig diabetes.The present study focused on anti-diabetic and anti-oxidative effect of Aloe vera (L.) in an in-vitro model. Wistar strain albino rats with less than 350 mg/dl of fasting blood glucose level on the 7th day of Streptozotocin (STZ) injection were considered for this study and left for obverting a chronic state of diabetes. On the 29th day of STZ injection, rats were sacrificed and targeted tissues were incubated for 2 hours in an in-vitro medium with 1, 2, and 4 mg of Aloe vera (L.) hydro-

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Li, Xiaoling, Gregor Römer, Raphaela P. Kerindongo, et al. "Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species." International Journal of Molecular Sciences 22, no. 11 (2021): 6044. http://dx.doi.org/10.3390/ijms22116044.

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SGLT-2i’s exert direct anti-inflammatory and anti-oxidative effects on resting endothelial cells. However, endothelial cells are constantly exposed to mechanical forces such as cyclic stretch. Enhanced stretch increases the production of reactive oxygen species (ROS) and thereby impairs endothelial barrier function. We hypothesized that the SGLT-2i’s empagliflozin (EMPA), dapagliflozin (DAPA) and canagliflozin (CANA) exert an anti-oxidative effect and alleviate cyclic stretch-induced endothelial permeability in human coronary artery endothelial cells (HCAECs). HCAECs were pre-incubated with on

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Rascón-Cruz, Quintín, Tania Samanta Siqueiros-Cendón, Luis Ignacio Siañez-Estrada, et al. "Antioxidant Potential of Lactoferrin and Its Protective Effect on Health: An Overview." International Journal of Molecular Sciences 26, no. 1 (2024): 125. https://doi.org/10.3390/ijms26010125.

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Chronic diseases, including cardiovascular and neurodegenerative diseases and cancer, are significant global health challenges. Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, is a critical factor in the progression of these pathologies. Lactoferrin (Lf), a multifunctional iron-binding glycoprotein, has emerged as a promising therapeutic agent due to its potent antioxidant, anti-inflammatory, and iron-regulating properties. Lf plays a pivotal role in iron homeostasis by chelating iron, modulating its cellular uptake, an

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Risha, Engy F., Fatma M. Abdelhamid, Walaa F. Awadin, et al. "Biochemical and Histological Analyses of Taurine’s Therapeutic Triad: Antidiabetic, Antioxidant, and Anti-inflammatory Effects in Alloxan-induced Diabetic Rats." Journal of the Anatomical Society of India 74, no. 2 (2025): 92–103. https://doi.org/10.4103/jasi.jasi_9_25.

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Background: Diabetes mellitus poses a significant health challenge worldwide. Oxidative stress, altered lipid profile, and inflammation are linked to diabetic complications. Objective: This work aimed to assess the effects of taurine (TAU) in alloxan (ALX)-induced diabetes in rats, evaluating its antihyperglycemic, antidyslipidemic, antioxidant, and anti-inflammatory effects. In addition, evaluating the effect of TAU on hepatic, renal, and cardiac complications. Materials and Methods: Fifty rats were divided into four groups, control, TAU, ALX, and ALX + TAU. At the end of the experiment, bloo

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Oliveira, Sara, Tamaeh Monteiro-Alfredo, Rita Henriques, et al. "Improvement of Glycaemia and Endothelial Function by a New Low-Dose Curcuminoid in an Animal Model of Type 2 Diabetes." International Journal of Molecular Sciences 23, no. 10 (2022): 5652. http://dx.doi.org/10.3390/ijms23105652.

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Curcumin has been suggested as a promising treatment for metabolic diseases, but the high doses required limit its therapeutic use. In this study, a new curcuminoid is synthesised to increase curcumin anti-inflammatory and antioxidant potential and to achieve hypoglycaemic and protective vascular effects in type 2 diabetic rats in a lower dose. In vitro, the anti-inflammatory effect was determined through the Griess reaction, and the antioxidant activity through ABTS and TBARS assays. In vivo, Goto-Kakizaki rats were treated for 2 weeks with the equimolar dose of curcumin (40 mg/kg/day) or cur

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