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Dissertations / Theses on the topic 'Anti-Tubercular'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dauda, Khadijah Tolulope. "Metal complexes of anti-tubercular drugs." Thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/28427.

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There is a continuing need to improve anti-tubercular drugs due to the development of resistance towards existing drugs. In some cases, metal complexes are known to improve the bioavailability of drugs. Hence the present study looks at the use of metal complexes of anti-tubercular drugs to improve the permeability and bioavailability of the drugs. The anti-tubercular drugs isoniazid (ISO), ethambutol (EMB), para-aminosalicylic acid (PAS), rifampicin (RFN) and pyrazinecarboxamide (PZA) were used in this study. Since the solubility and hence permeability and bioavailability of the drugs depend o

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2

Nkanga, Christian Isalomboto. "Inhalable particulate systems for anti-tubercular drug delivery." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/37966.

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Tuberculosis (TB) is a deadly infectious microbial disease that is currently dominating public health concerns. Among the pharmacological issues in the management of TB are the poor bioavailability of some anti-TB drugs, mostly due to the fast first-pass metabolism, and high drug load needed for combination therapy. These result in a lengthy treatment with several adverse effects causing decreased patient compliance. These factors often lead to the therapeutic failure and promote the development of drug resistant strains, justifying the urgent need for new therapeutic strategies. Liposomes are

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3

Shah, Manish Bipin. "The development of novel quinols as anti-tubercular agents." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431861.

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4

Cox, Jonathan A. G. "Identifying the mode of action of novel anti-tubercular drugs." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6278/.

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The demand for novel antibiotics in the treatment of infections by \(Mycobacterium\) \(tuberculosis\) (\(M.\) \(tb\)), the causative agent of tuberculosis (TB) has reached new highs with the recent emergence of totally-drug resistant TB (TDR-TB). Efforts to develop antibiotics with revolutionary mechanisms of action, low minimal inhibitory concentrations (MICs) that will decrease the current drug burden and clear infection without compromising side effects has led to several collaborative efforts between pharmaceutical companies and academic institutions throughout the world. This interdiscipl

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5

Joseph, Laurelle Margaux. "Supramolecular derivatisation of new anti-tubercular and antimalarial drug leads." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/19974.

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The UCT Drug Discovery and Design Centre, H3D, provided anti-tubercular and antimalarial drug leads that display potent in vitro and in vivo activity, but with unfavourable physicochemical properties. The primary objective of this study was to prepare supramolecular derivatives of the drug leads in an attempt to improve their physicochemical properties. Any new solid forms were to be characterized by a variety of analytical techniques, including X-ray analysis, spectroscopic and thermal techniques. Where possible, such derivatives would be tested for any enhancement in the aqueous solubility o

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6

Odumosu, Patricia. "Evaluation of the plant extracts of an anti-tubercular herbal remedy." Thesis, University of Sunderland, 2012. http://sure.sunderland.ac.uk/3330/.

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Ximenia americana root bark (Olacaceae) and Pavetta crassipes (Rubiaceae) leaf used in Nigerian traditional medicine were tested individually against clinical isolate of Mycobacterium tuberculosis by Lowenstein - Jensen method. Crude aqueous extracts of X. americana and P. crassipes exhibited minimum inhibitory activity (MIC) of 100 μg/mL and 200 μg/mL respectively. Sequential screening with solvents of different polarities was used in evaluation tests to readily locate the source of the activity against tuberculosis and for conditions related to skin diseases since it was readily available. I

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7

Bensaber, Salah M. "The design and synthesis of thiolactomycin analogues as potential anti-tubercular agents." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501828.

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TB is the second leading cause of morbidity world wide caused by a single infectious organism. One third of the world's population are infected with the causative agent, Mycobacterium tuberculosis, and every year it kills 1.7 million people. There is an urgent need to find new Anti - TB that are efficacious, affordable and compatible with HIV and other Anti - TB used in developing countries, where the disease is prevalent. These drugs must also shorten treatment time and be active against resistant forms of the mycobacteria that will help increase patient compliance. One such lead compound whi

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8

Abuhammad, Areej. "Arylamine N-Acetyltransferases from mycobacteria : investigations of a potential target for anti-tubercular therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3f571661-7b51-4fa8-bf5e-2adff9269c59.

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Reactivation of latent infection is the major cause of tuberculosis (TB). Cholesterol is a critical carbon source during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids. Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the sterol-ring degradation and is essential for intracellular survival. NAT from M. tuberculosis (TBNAT) can utilise propionyl-CoA and therefore was proposed as a target for TB-drug development. Deleting the nat gene or inhibiting the NAT enzyme p

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9

Alsayed, Shahinda Sayed Rabie. "Design, Synthesis and Biological evaluation of Novel Indole2-carboxamide Derivatives as Anti-tubercular Agents." Thesis, Curtin University, 2021. http://hdl.handle.net/20.500.11937/88253.

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10

Singh, U. "Approach towards identification of anti-tubercular lead molecules by targeting mycobacterium tuberculosis glutamine synthetase." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2010. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3748.

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11

Marakalala, Mohlopheni Jackson. "Inhibition of a Mycothiol biosynthetic enzyme and a detoxification enzyme as anti-tubercular drug targets." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/2694.

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12

Bamuamba, Kapinga Benoit. "Pharmacognostic study of 5 medicinal plant species from Western Cape Province (South Africa) for anti-tubercular activity." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/4241.

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Includes bibliographical references (leaves 126-140).<br>In our search for new anti-tuberculosis lead molecules, five medicinal plant species, Olea capensis (L.l, Tulbaghia alliacea (L.), Inula graveolens (L.), Leyssera gnaphaloides (L.), and Buddleja saligna (L.) were collected in Cape Town and surrounding area and investigated for antimycobacterial activity following report of their therapeutic use in traditional medicine to treat infectious diseases such as tuberculosis. A bioassay guided fractionation of the acetone/water (4:1) crude extracts of O. capensis (leaves) and T. alliacea (rhizom

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13

Huang, Cheng-I., and 黃政議. "Chemical constituents and anti-tubercular activity fromthe leaves of Symplocos anomala." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/24650080868175986844.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>102<br>Symplocos anomala Brand (Symplocaceae) is a small tree. It distributes at Okinawa, Southeast Asia, Southern China, and Taiwan. Saponins, triterpenoids, flavonoids, lignans, phenols, alkaloids, sterols, and iridoids are widely occurred in Symplocos, which is the only genus in Symplocaceae. Approximately about 1,400 species of Formosan plants have been screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro. The methanolic extract of the leaves of this plant showed significant anti-tubercular activity in vitro. The chemical consti

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14

Lu, Ying-Chen, and 盧盈辰. "Chemical Constituents and Anti-tubercular Activity from the Unripe Pulp of Persea americana." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/60759555838546166920.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>99<br>Persea americana Mill. (Lauraceae) is an evergreen tree, distributed in tropical and subtropical regions around the world. Until now, the bark, leaves, fruits and seeds of P. americana have been extensively studied. Previous studies on this plant identified various classes of chemical constituents, such as monoterpenoids, sesquiterpenoids, triterpenoids, flavonoids, steroids, and carotenoids, and especially long-chain fatty alcohol derivatives. From the previous investigations, this plant showed numerous bioactivities, including cytotoxicity, antifungal, antiba

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15

Anand, Praveen. "Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3951.

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BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large number of protein structures have been determined at a high resolution using various experimental techniques such as X-ray crystallography, NMR, electron microscopy and made publicly available through the Protein Data Bank. In the recent years, comprehending function by studying a large number of related proteins is proving to be very fruitful for understanding their biologica

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16

Anand, Praveen. "Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery." Thesis, 2015. http://etd.iisc.ernet.in/2005/3951.

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BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large number of protein structures have been determined at a high resolution using various experimental techniques such as X-ray crystallography, NMR, electron microscopy and made publicly available through the Protein Data Bank. In the recent years, comprehending function by studying a large number of related proteins is proving to be very fruitful for understanding their biologica

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17

Padiadpu, Jyothi. "An Integrated Systems Biology Approach to Study Drug Resistance in Mycobacteria." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3750.

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Emergence of drug resistance is a major problem in the treatment of many diseases including tuberculosis. To tackle the problem, it is essential to obtain a global perspective of the molecular mechanisms by which bacteria acquire drug resistance. Systems biology approaches therefore become necessary. This work aims to understand pathways to drug resistance and strategies for inhibition of the resistant strains by using a combination of experimental genomics and computational molecular systems approaches. Laboratory evolution of Mycobacterium smegmatis MC2 155 by treatment with isoniazid (INH)

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18

Padiadpu, Jyothi. "An Integrated Systems Biology Approach to Study Drug Resistance in Mycobacteria." Thesis, 2015. http://etd.iisc.ernet.in/2005/3750.

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Emergence of drug resistance is a major problem in the treatment of many diseases including tuberculosis. To tackle the problem, it is essential to obtain a global perspective of the molecular mechanisms by which bacteria acquire drug resistance. Systems biology approaches therefore become necessary. This work aims to understand pathways to drug resistance and strategies for inhibition of the resistant strains by using a combination of experimental genomics and computational molecular systems approaches. Laboratory evolution of Mycobacterium smegmatis MC2 155 by treatment with isoniazid (INH)

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19

Chakraborti, Sohini. "Protein-small molecule interactions: Structural insights and applications in computational drug discovery." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5520.

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Deviation from normal healthy conditions, termed as disease, can often be triggered due to the malfunctioning of proteins. Modulating the functions of proteins by administering therapeutic agents (drugs) may alleviate the disease conditions. The majority of the drugs currently available in the market are small organic molecules due to their pharmacological and commercial advantages. These small molecule drugs interact with the protein targets through specific sites on the surface of the protein structure (binding sites). Thus, the structural data of protein-small molecule complexes forms a cru

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