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Journal articles on the topic 'Anti-Tubercular'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Sreelatha, Motimi, Bachu Naveena, and Yadala Prapurna Chandra. "A Review Study on Safety and Efficacy on Second Line Anti Tubercular Drugs." International Journal of Experimental and Biomedical Research 2, no. 3 (2023): 132–38. http://dx.doi.org/10.26452/ijebr.v2i3.538.

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Due to intestinal dysbiosis brought on by second-line anti-tubercular medication therapy, the patient's resistance to MTB appears to have decreased. This is likely due to an impact on immune cell proliferation and autophagic processes. therefore adversely influencing the patients' treatment results. The objectives of review articles are the safety and efficacy on the second line anti tubercular drugs. The results of these review article in the year 2015 to 2020. The conversation of these review article is the safety and efficacy of second line anti tubercular drugs . The discussion of these st

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2

Yogesh, Joshi 1. *. Rohit Bangwal 1. Shalini Rawat 1. Dev Singh Jangpani 2. "DRUG-INDUCED HEPATOTOXICITY OF ANTI-TUBERCULAR DRUGS THERAPY: A CASE REPORT." Journal of Pharma Research 8, no. 5 (2019): 266–68. https://doi.org/10.5281/zenodo.2678008.

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<strong><em>ABSTRACT</em></strong> <strong><em>A</em></strong><em>ccording to WHO, one third of the population is affected by TB and 1 in 4 adult male deaths is attributed to TB. The first line anti-TB drugs are potentially hepatotoxic. The incidence rate of anti-TB drugs induced hepatotoxicity has found to be 2% to 28% in India. A case of 62 years old man, weighing 49 kg was brought to hospital with chief complains of coughing, loss of appetite vomiting, melaena, fever, gastritis since 3 days. He had a history of pulmonary koch’s 15 days back and was taking regular first line anti-tuber

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3

Chen, Wei, Pengmian Feng, and Fulei Nie. "iATP: A Sequence Based Method for Identifying Anti-tubercular Peptides." Medicinal Chemistry 16, no. 5 (2020): 620–25. http://dx.doi.org/10.2174/1573406415666191002152441.

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Background: Tuberculosis is one of the biggest threats to human health. Recent studies have demonstrated that anti-tubercular peptides are promising candidates for the discovery of new anti-tubercular drugs. Since experimental methods are still labor intensive, it is highly desirable to develop automatic computational methods to identify anti-tubercular peptides from the huge amount of natural and synthetic peptides. Hence, accurate and fast computational methods are highly needed. Methods and Results: In this study, a support vector machine based method was proposed to identify anti-tubercula

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4

Shrivastava, Rimjhim. "Anti-Tubercular Drugs Induced Hepatotoxicity." Annals of Pediatric Gastroenterology & Hepatology 3, no. 2 (2022): 1–3. http://dx.doi.org/10.5005/jp-journals-11009-0074.

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5

Kalani, Komal, Vinita Chaturvedi, Priyanka Trivedi, Sudeep Tondon, and Santosh Kumar Srivastava. "Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents." Current Topics in Medicinal Chemistry 19, no. 8 (2019): 594–99. http://dx.doi.org/10.2174/1568026619666190304142802.

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Background: Tuberculosis is one of the leading causes of mortality worldwide. Resistance against the frontline anti-tubercular drugs has worsened the already alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-tubercular agents possessing novel modes of action. Objective: Chemical transformation of dihydroartemisinin for anti-tubercular lead optimization. Methods: Dihydroartemisinin, a metabolite of artemisinin was chemically converted into eight acyl derivatives and were evaluated for anti-tubercular potential against H37R

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6

Bangwal, Rohit, Yogesh Joshi, and Jagdish Kumar Rawat. "HEPATITIS INDUCED BY ANTI-TUBERCULAR THERAPY AND CHRONIC ALCOHOLISM: A CASE REPORT." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 598–600. http://dx.doi.org/10.22270/jddt.v9i4.3205.

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Anti-tubercular drugs induced hepatotoxicity, which is a serious problem and it was reported that worldwide 2-32% of TB patients experience drug induced hepatotoxicity (DIH) during the course of the treatment. A 65 year old male, 47 kg weight and chronic alcoholic was brought to a tertiary care hospital in semi-conscious condition with chief complains of vomiting, cough with expectoration, loss of appetite, shortness of breath, fever (on & off) since 4 days. He had a history of smear positive pulmonary koch’s 10 days back and was taking regular first line anti-tubercular drug therapy (Ison

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7

Mujeeb, Samar, Kuldeep Singh, Bhumika Yogi, Praveen Kumar, and Piyush Kumar. "Design, Synthesis and Anti-tubercular Evaluation of Some Novel Chroman-Hydrazone Derivatives." Asian Journal of Chemistry 35, no. 2 (2023): 483–92. http://dx.doi.org/10.14233/ajchem.2023.27002.

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The molecular docking, synthesis, spectral characterization and anti-tubercular evaluation of 10 novel N’-substituted-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbohydrazide derivatives (SM1-SM10) were reported. The structures of the synthesized derivatives were affirmed by spectroscopic studies such as FTIR, 1H NMR, 13C NMR and high resolution-mass spectrometry. Predicted ADME and toxicity investigations were accomplished to presume the pharmacokinetic parameters of the compounds. The synthesized compounds were evaluated for in vitro anti-tubercular activity against Mycobacterium tuberculosis H

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8

J., Madhusudhanan. "Investigation of Anti-tubercular Activity of Solanum Nigrum." Journal of Advanced Research in Dynamical and Control Systems 12, SP4 (2020): 1473–87. http://dx.doi.org/10.5373/jardcs/v12sp4/20201626.

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9

Mohiuddin, Md, and J. Ashraful Haq. "First Line Anti-Tubercular Drug Resistance Pattern of Mycobacterium Tuberculosis Isolated From Specialized Hospitals of Dhaka City." Ibrahim Medical College Journal 8, no. 2 (2016): 41–46. http://dx.doi.org/10.3329/imcj.v8i2.26677.

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The present study was undertaken to determine the drug resistance pattern of M. tuberculosis isolated from 225 pulmonary and 45 extrapulmonary tuberculosis cases. The samples were cultured on Lowenstein Jensen (L-J) media for isolation of M. tuberculosis. Drug resistance to first line anti tubercular drugsnamely isoniazid (INH), rifampicin (RIF), Ethambutol (ETH) and streptomycin (SM) were determined by indirect proportion method. The overall drug resistance of M. tuberculosis was 53.6% to any of the first line anti tubercular drugs. Rate of multi drug resistant tuberculosis (MDR-TB) among the

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10

Bangwal, Rohit, Mashud Mohd Essar Hussain, Saurabh Saklani, Prashant Mathur, and Yogesh Joshi. "Hepatotoxicity Induced by Anti-Tubercular Drugs Therapy: A Case Report." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 195–98. http://dx.doi.org/10.22270/jddt.v10i5-s.4463.

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Anti-tubercular therapy induced liver injury (ATTILI) is the most important risk for the past many years. Many pre-existing factors and conditions like persisting liver injury, female gender, alcohol abuse etc. are important risk factors for the ATT induce liver injury. I read many case reports and literature review for the drugs induce liver injury, and concluded the results, ATT drugs are the most responsible for the liver injury during the therapy periods. The present case was 42-year-old male patient and known case of pulmonary tuberculosis, patients were on the ATT drugs therapy in the la

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11

Bruiners, Natalie, Noton K. Dutta, Valentina Guerrini, et al. "The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis." Journal of Lipid Research 61, no. 12 (2020): 1617–28. http://dx.doi.org/10.1194/jlr.ra120000895.

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The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, the underlying molecular mechanisms are unknown. In this study, we used an in vitro macrophage infection model to investigate simvastatin’s anti-tubercular activity by systematically inhibiting each branch of the mevalonate pathway and evaluating the effects of the branch-specific inhibitors on mycobacterial growth. The anti-tubercular

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12

Srinivasarao, Singireddi, Adinarayana Nandikolla, Amaroju Suresh, et al. "Correction: Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents." RSC Advances 10, no. 32 (2020): 18907. http://dx.doi.org/10.1039/d0ra90059a.

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Correction for ‘Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents’ by Singireddi Srinivasarao et al., RSC Adv., 2020, 10, 12272–12288, DOI: 10.1039/D0RA01348J.

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13

Rath, Goutam, Deepak Pradhan, Goutam Ghosh, and Amit K. Goyal. "Challenges and Opportunities of Nanotechnological based Approach for the Treatment of Tuberculosis." Current Pharmaceutical Design 27, no. 17 (2021): 2026–40. http://dx.doi.org/10.2174/1381612827666210226121359.

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Mycobacterium tuberculosis, because of its unique biochemical behavior and a complex host relationship, successfully evades the host immune system. Therefore, chemotherapy appears to be the first-line option for patients with tuberculosis. However, poor patient compliance with anti-tubercular treatment and variability in anti-tubercular drug pharmacokinetics are among the major driving factors for the emergence of drug resistance. The rising cases of extrapulmonary TB, cross-resistance patterns, high prevalence of tuberculosis and HIV co-infections make tuberculosis treatment more complicated

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14

Palikhey, Anjan, Dil Kapoor Kohar, Amit Kumar Shrivastava, et al. "Adherence to Anti-tubercular Agents in DOTS Center in Western Nepal." MedS Alliance Journal of Medicine and Medical Sciences 2, no. 3 (2022): 6–11. http://dx.doi.org/10.3126/mjmms.v2i3.47654.

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INTRODUCTION: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and is one of the major public health problems in developing countries like Nepal. Despite the availability of effective tuberculosis treatment regimens, patients must take a combination of anti-tubercular drugs for at least six months and may endure numerous side effects, making treatment compliance exceedingly difficult to maintain. The primary objective of the study was to assess the adherence rate to anti-tubercular agents and to find the prevalence of adverse drug reactions to the anti-tubercular ther

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15

Moumita, Hazra. "A Rational Pharmacotherapeutic Research Study on the Prescription Patterns of Anti-Tubercular Drugs Monotherapy or Combination Therapies in Multi Drug-Resistant Tuberculosis Patients at Tertiary Patientcare Hospitals." International Journal of Toxicological and Pharmacological Research 12, no. 3 (2022): 53–59. https://doi.org/10.5281/zenodo.12508804.

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<strong>Background: </strong>This rational pharmacotherapeutic appraisal study was conducted to assess the maintenance of the various aspects of rational pharmacotherapeutics, including appropriateness, efficacy, safety, availability, and ease of administration in prescribing different anti-tubercular drugs, like ofloxacin, delamanid or bedaquiline, which reflected upon the prescription percentages of these drugs, thus delineating the choice of drugs, treatment regimens and the routine prescription patterns of anti-tubercular monotherapy or combination therapies, among multi-drug resistan

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16

Polak, Żaneta, and Lucyna Kapka-Skrzypczak. "Anti-tubercular substances produced by plants." Journal of Pre-Clinical and Clinical Research 11, no. 2 (2017): 147–52. http://dx.doi.org/10.26444/jpccr/81231.

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17

Zaki, SyedAhmed, and Prithi Shenoy. "Paradoxical response to anti-tubercular treatment." Indian Journal of Pharmacology 43, no. 2 (2011): 210. http://dx.doi.org/10.4103/0253-7613.77377.

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18

Aggarwal, Ramesh, Shridhar Dwivedi, and Meenakshi Aggarwal. "Unfamiliar manifestations of anti-tubercular therapy." Journal of Family Medicine and Primary Care 3, no. 1 (2014): 72. http://dx.doi.org/10.4103/2249-4863.130327.

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19

Kadam Manish, S., Nagappa Anantha Naik, and Kishore Gnana Sam. "Recent Advances in Anti Tubercular Drugs." Journal of Pharmaceutical Research 9, no. 2 (2010): 39. http://dx.doi.org/10.18579/jpcrkc/2010/9/2/79482.

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20

M, Srikanth, Prasadarao M, Badrinath B, et al. "ANTI-TUBERCULAR ACTIVITY OF OXYSTELMA ESCULANTUM." International Research Journal of Pharmacy 8, no. 5 (2017): 73–76. http://dx.doi.org/10.7897/2230-8407.08577.

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21

Garg, Pankaj. "Irrational use of anti-tubercular therapy." Indian Journal of Pediatrics 72, no. 8 (2005): 713. http://dx.doi.org/10.1007/bf02724088.

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22

Whittington, R. M. "Fatal hepatotoxicity of anti-tubercular chemotherapy." Lancet 338, no. 8774 (1991): 1083–84. http://dx.doi.org/10.1016/0140-6736(91)91943-o.

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23

Latheef, A. A. "SURVEILLANCE OF ANTI TUBERCULAR DRUG RESISTANCE." Journal of Nepal Medical Association 41, no. 144 (2003): 531–32. http://dx.doi.org/10.31729/jnma.726.

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24

GC, G., Basista Rijal, and A. P. Sharma. "SURVEILLANCE OF ANTI-TUBERCULAR DRUG RESISTANCE." Journal of Nepal Medical Association 41, no. 142 (2003): 311–13. http://dx.doi.org/10.31729/jnma.749.

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Tuberculosis is the leading cause of death in Nepal. Failure in early detection anddrug resistance are two most important problems in treatment and cure of thetuberculosis. The objective of the study was to assess the drug resistance pattern inMycobacterium tuberculosis isolated in Tribhuvan University teaching Hospital. Morethan 85% of isolates were sensitive to all the four drugs and 5.5% of isolates weremultidrug resistant. The drug resistant isolates were obtained more frequently frompreviously treated patients. More extensive studies should be carried out by independentorganizations to co

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25

Kishore, Navneet, Bhuwan B. Mishra, Vyasji Tripathi, and Vinod K. Tiwari. "Alkaloids as potential anti-tubercular agents." Fitoterapia 80, no. 3 (2009): 149–63. http://dx.doi.org/10.1016/j.fitote.2009.01.002.

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26

Nutan, Shriram Bhoi Ms. Monika Ola* Mrs. Rajveer Bhaskar Nilesh Suresh Sathe Vaibhav Ghansham kute Rajeshwari satish patil. "RIFAMPICIN: ANTI TUBERCULAR DRUG: AN OVERVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9585–95. https://doi.org/10.5281/zenodo.2842261.

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<em>The World Health Organization inspires the use of fixed dose combination (FDC) of rifampicin combination used with isoniazid, isoniazid with pyrazinamide or pyrazinamide with ethambutol for the treatment of tuberculosis. Hence, it’s used worldwide for reducing the risk of emerging drug resistance. Rifampicin is one of the potent and broad spectrum antibiotics against bacterial pathogen. It works by inhibits the DNA dependent RNA polymerase activity by forming stable complex with enzyme. Here, the polymorphic form of rifampicin is describe by thermal study of rifampicin. The thermal b

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27

B., Rajitha* B. Rashmitha S. Ashwini K. Neha N. Prasad M. Ashwini. "An Overview on Synthesis, Properties and Biological Activities of Imidazole and Its Derivatives." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2444–53. https://doi.org/10.5281/zenodo.15083575.

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Imidazole belongs to the class of five membered heterocyclic compounds which plays a major role in Medicinal Chemistry. It was synthesized by different methods using different chemicals. This article reviews different methods of synthesis, properties of imidazole, both its natural and synthetic derivatives and pharmacological activities. Imidazole shows wide variety of biological activities such as anti-tubercular activity, anti-inflammatory activity, antimicrobial activity, anthelmintic activity, anti-cancer activity etc., this article reflects on anti-tubercular activity, anti-inflammatory a

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28

Ega, D., Z. Attari, J. Mudgal, I. Bairy, S. Vishnuprasad, and G. K. Nampurath. "ANTI-TUBERCULAR ACTIVITY OF SYNTHESIZED NOVEL 2,5-DISUBSTITUTED-1,3,4-OXADIAZOLE DERIVATIVES." INDIAN DRUGS 52, no. 02 (2015): 40–44. http://dx.doi.org/10.53879/id.52.02.10107.

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A few novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and evaluated for antitubercular activity. The anti-tubercular activity was carried out as per the Rist and Grosset proportion method. Among the eight derivatives, the compounds substituted at ortho-position of the aromatic ring showed anti-tubercular activity comparable with the standard, isoniazid.

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29

Mahajan, Neetin, Tushar C. Patil, Sunny Sangma, and Kartik P. Pande. "Two rare cases of management of proximal phalanx spina ventosa." International Journal of Research in Orthopaedics 9, no. 3 (2023): 607–10. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20231192.

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Tubercular dactylitis or spina ventosa is the tubercular infection of phalanges, metacarpals and metatarsals termed after cystic swelling of short tubular bones by tubercular infection. Here we presented two rare cases of spina ventosa in a 10 years old female and a 16 years old male patients. In both cases there was swelling of digits with stiffness. The radiographs were suggestive of chronic osteolytic infection with cortical destruction and diffuse sclerosis. We managed them with adequate surgical debridement, splintage and anti-tubercular therapy with good functional recovery. Spina ventos

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30

Prasai, Parikshit, Anjali Joshi, Santosh Poudel, Sarjan K.C., and Rabin Pahari. "Cecal Perforation Following Intraperitoneal Abscess after Anti-tubercular Therapy: A Case Report." Journal of Nepal Medical Association 61, no. 258 (2023): 175–78. http://dx.doi.org/10.31729/jnma.8042.

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Abdominal tuberculosis is defined as infection of gastrointestinal tract, peritoneum, abdominal solid organs, and/or abdominal lymphatics constituting approximately 12% of extra-pulmonary tuberculosis cases. Intestinal perforation is an acute presentation of abdominal tuberculosis. Intestinal perforation can occur before or at the beginning of anti-tubercular therapy. It is considered to be a paradoxical reaction if it occurs during or after treatment. Intestinal perforation is uncommon but serious and life-threatening as complication-mortality rate secondary to perforation are estimated to be

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31

SACHDEVA, Arora, Sachet DAWAR, Sunil NAGAR, and Deepali PARASHAR. "Lichenoid Skin Reaction in a Patient on Anti-Tubercular Drugs: a Rare Case Report Ruchi." Medicina Moderna - Modern Medicine 27, no. 4 (2020): 305–8. http://dx.doi.org/10.31689/rmm.2020.27.4.305.

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First line anti-tubercular drugs are known to cause various adverse drug reactions including cutaneous reactions. We report a rare case of anti-tubercular treatment (ATT) induced lichenoid skin reaction in a 58 years old female with no prior history of rashes. She was put on fi xed dose combination (FDC) tablets of fi rst line anti-tuberculosis drugs and developed reaction one month after initiation of therapy.

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32

Kumar, A., M. Maheshwari, and J. Biswas. "Paradoxical worsening of presumed tubercular serpiginous like choroiditis on anti-tubercular therapy." Journal of Clinical Research and Ophthalmology 6, no. 2 (2019): 028–30. http://dx.doi.org/10.17352/2455-1414.000060.

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33

Venugopala, Katharigatta N., Sandeep Chandrashekharappa, Melendhran Pillay, et al. "Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification." Medicinal Chemistry 15, no. 3 (2019): 311–26. http://dx.doi.org/10.2174/1573406414666180703121815.

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Background: Benzothiazole derivatives are known for anti-TB properties. Based on the known anti-TB benzothiazole pharmacophore, in the present study, we described the synthesis, structural elucidation, and anti-tubercular screening of a series of novel benzothiazole (BNTZ) derivatives (BNTZ 1–7 and BNTZ 8–13). Objective: The study aims to carry out the development of benzothiazole based anti-TB compounds. Methods: Title compounds are synthesized by microwave method and purified by column chromatography. Characterization of the compounds is achieved by FT-IR, NMR (1H and 13C), LCMS and elementa

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34

Sitaula, Sanjeeta, Ranju Kharel Sitaula, Shilu Thapa, Sameer Chapagain, and Hira Nath Dahal. "Ocular toxicity among patients taking anti-tubercular treatment." Nepalese Journal of Ophthalmology 14, no. 2 (2022): 4–15. http://dx.doi.org/10.3126/nepjoph.v14i2.42455.

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Introduction: Tuberculosis remains a major public health problem in Nepal and anti-tubercular drugs used for the treatment of pulmonary and extrapulmonary tuberculosis can be associated with ocular toxicity. This prospective study aimed to evaluate the incidence of ocular toxicity among patients receiving anti-tubercular therapy and to assess the change in visual functions and ocular imaging before and after use of anti-tubercular therapy. Materials and methods: A total of 89 eyes of 45 TB patients taking anti-tubercular therapy were enrolled. Detailed history and examination including best-co

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35

Xu, Zhi, Shijia Zhao, Zaosheng Lv, et al. "Benzofuran derivatives and their anti-tubercular, anti-bacterial activities." European Journal of Medicinal Chemistry 162 (January 2019): 266–76. http://dx.doi.org/10.1016/j.ejmech.2018.11.025.

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Ullah, Quadrat-A.-Eahsan, and Mohammad Abdul Quader. "Tubercular Dactylitis in a 5-Year Girl: A Case Report on Uncommon Presentation of Skeletal Tuberculosis." European Journal of Medical and Health Sciences 5, no. 5 (2023): 48–50. http://dx.doi.org/10.24018/ejmed.2023.5.5.1933.

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Tuberculosis of the spinal cord, which is known as tubercular spondylitis is the most manifested musculoskeletal TB. Tuberculosis also affects the hip joint, knee joint, wrist, and elbow joint in descending order. Tubercular Dactylitis is a less common form of extra-pulmonary tuberculosis, which involves the small bones of the hand and feet. Tuberculosis causes granuloma formation in short tubular bones resulting in spindle shaped swelling, which is Spina Ventosa. A5 years old Bangladeshi girl presented to the orthopaedics department with a history of pain-free gradual expansion of the middle

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Sri G, Navya, Feba Stanly, Georgina Sarah, Prasad Bali, and Varsha Dalal. "ATT-Therapy Induced DRESS: A Case Report." Journal of Drug Delivery and Therapeutics 11, no. 5-S (2021): 1–5. http://dx.doi.org/10.22270/jddt.v11i5-s.5060.

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A severe adverse reaction called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS syndrome), is usually described by eosinophilia, fever, swollen lymph nodes, severe skin rash and extensive systemic association. It is distinguished by a lengthy latency period, which is characteristic drug reaction with eosinophilia and systemic symptoms (DRESS). Formerly known as drug-induced delayed multi-organ hypersensitivity syndrome (DIDMOHS) or drug-induced hypersensitivity (DIHS). There are a variety of clinical symptoms associated with the syndrome yet it is still poorly understood. Drugs m

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38

Brhane, Yonas, Tesfaye Gabriel, Tigist Adane, Yemisrach Negash, Henok Mulugeta, and Mulugeta Ayele. "Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 3 (2019): 4524–30. http://dx.doi.org/10.37285/ijpsn.2019.12.3.2.

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Tuberculosis (TB) is a contagious infectious illness caused by species having a place with the Mycobacterium tuberculosis complex. The clinical management of tuberculosis still remains a difficult task. Treatment of TB with anti-tubercular drugs becomes the only option available. Hence, the goals of treatment are ensure cure without relapse, prevent death, impede transmission, and prevent emergence of drug resistant strains. This review describes the latest developments and innovative drug delivery strategies for treatment of TB in order to improve the therapeutic efficacy and reduce toxic eff

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39

Rasmi S Nair, Akhilesh K, and Emmanuel James. "Anti-tubercular drugs, predisposing factors and management of drug-induced hepatotoxicity: A concise and up-to-date." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3096–104. http://dx.doi.org/10.26452/ijrps.v11i3.2418.

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Tuberculosis remains a leading cause of death in developing countries. In India antitubercular treatment was effective from the 1950s and has been engaged for more than 50 years. Hepatotoxicity secondary to antitubercular drug treatment is a major threat to tuberculosis. Anti-tubercular drugs like isoniazid, rifampicin, and pyrazinamide are potentially hepatotoxic and their adverse reactions are based on dose or hypersensitivity. Hepatotoxicity can occur within a few weeks of initiating intensive phase and elevation of serum transaminase levels with signs and symptoms are considered as the dia

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T, Rajkumar, and Srinivasan N. "Microplate Alamar Blue assay for detecting anti-tubercular action of Albizia amara leaves." International Journal of Ayurvedic Medicine 14, no. 2 (2023): 437–41. http://dx.doi.org/10.47552/ijam.v14i2.3473.

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Albizia amara (Roxb.) B. Boivin has been used historically for the treatment of septicaemia, malignancy, delirium, and convulsions. A decoction made from the bark is used to treat rheumatism, hemorrhage, and some bleeding disorders during pregnancy, as well as stomach pain and nasal issues. Albizia has active ingredients like flavonoids, alkaloids, steroids, phenolic compounds, and tannins, according to early phytochemical screening. Flavonoids and phenolic compounds have been shown to play an important role in anti-tubercular activity in previous research. This led us to investigate whether o

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41

Gupta, Nandini, Divyanshu Sharma, and Darshan Parikh. "Tuberculous otomastoiditis: analysis of otological tuberculosis with intact tympanic membrane." International Journal of Otorhinolaryngology and Head and Neck Surgery 10, no. 1 (2024): 100–103. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20240067.

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In recent years extra pulmonary tuberculosis has more frequently been associated with mastoiditis in patients with immunodeficiency state. Although tuberculosis of the mastoid or otomastoiditis is a very rare complication of tuberculosis today, when occurs it may cause significant morbidity. Complications such as facial paralysis and permanent hearing loss may develop. Our purpose was to evaluate the differential findings of tuberculous otomastoiditis and evaluation of outcomes in patients undergoing surgery along with anti-tubercular therapy rather than patients receiving only anti-tubercular

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Chowdhury, Forhad Hossain, Nur Mohammad, Mohammod Raziul Haque, Zahed Hossain, Md Abdus Salam, and Mainul Haque Sarker. "Tubercular Lesions in Brain Parenchyma." Bangladesh Journal of Infectious Diseases 5, no. 2 (2019): 45–60. http://dx.doi.org/10.3329/bjid.v5i2.42151.

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Background: Preoperative neuro-radiological features of tuberculosis involving brain lesions may mimic neoplastic lesions of brain & skull base and post operative histopathological study or response to empirical anti-tubercular therapy brings the ultimate diagnosis. Objective: Here we present our experience of 76 cases of cerebral and cerebellar tuberculosis that was managed surgically with anti-tubercular drugs or medical treatment alone without histopathological confirmation. Methodology: All cases of brain parenchymal tuberculosis confirmed histopathologically after surgery

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Lal, Atil Kumar, Sudhir Shyam Kushwaha, Ajay Bharti, and Mahima Pandey. "Tuberculosis of sternoclavicular joint: a rare case report." International Journal of Research in Orthopaedics 6, no. 5 (2020): 1117. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20203739.

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<p>Osteoarticular tuberculosis comprises 10-15% of the all cases of extrapulmonary tuberculosis. Tubercular involvement of the sternoclavicular joint is very rare. We hereby present a rare case report of the 38 year old female with sternoclavicular joint tuberculosis with cold abscess. The diagnosis was confirmed by FNAC and on ZN staining AFB was isolated. Patient was managed successfully by the anti-tubercular therapy at the end of the treatment. So, a degree of suspicion of the tuberculosis at these rare sites along with investigation followed by anti-tubercular therapy leads to succe

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Babu, Aravinda, Kenchaiah Sunil, Ayyiliath Meleveetil Sajith, et al. "NMI-SO2Cl2-Mediated Amide Bond Formation: Facile Synthesis of Some Dihydrotriazolopyrimidine Amide Derivatives as Potential Anti-Inflammatory and Anti-Tubercular Agents." Pharmaceuticals 17, no. 5 (2024): 548. http://dx.doi.org/10.3390/ph17050548.

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Facile access to some novel biologically relevant dihydrotriazolopyrimidine carboxylic acid-derived amide analogues using NMI/SO2Cl2, and aromatic and aliphatic primary and secondary amines, is reported herein. The role of N-methylimidazole (NMI) as the base and sulfuryl chloride (SO2Cl2) as the coupling reagent has been effectively realized in accessing these molecules in good to excellent yields. The feasibility of the developed protocol has also been extended to the gram-scale synthesis of N-benzylbenzamide in a 75% yield from benzoic acid and benzyl amine. The newly synthesized compounds w

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Archana, S.* Dr. Sapna Shrikumar. "Phytosomal Formulation of Clerodendrum Infortunatum for Anti- Tubercular Activity and Development of a Therapeutic Suspension." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1051–66. https://doi.org/10.5281/zenodo.15183026.

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Background: Tuberculosis (TB) continues to pose a significant global health challenge, necessitating the development of novel therapeutic approaches. Clerodendrum infortunatum, a medicinal plant with traditional therapeutic uses, contains bioactive constituents like flavonoids and terpenoids with known anti-tubercular properties. Phytosome technology offers a promising platform to enhance the bioavailability and efficacy of plant-derived compounds. Aim: This study aimed to formulate and evaluate phytosomes prepared from the ethanolic extract of Clerodendrum infortunatum leaves for anti-tubercu

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Chaskar, Pratip K., and Rakesh R. Somani. "EXPLORING NOVEL NCEs TARGETING InhA AS PROSPECTIVE KEY COMPOUNDS TO TREAT TUBERCULAR INFECTIONS: A COMPUTATIONAL APPROACH." INDIAN DRUGS 61, no. 09 (2024): 21–35. https://doi.org/10.53879/id.61.09.14685.

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The main goal of this research was to investigate unique molecules for potential anti-tubercular properties. These NCEs are targeted as inhibitors of InhA, a pivotal mediator in tubercular infections. This exploration was carried out through computational molecular docking. In lieu of prior research, we conducted an in silico analysis of various potential and reported anti-tubercular and anti-bacterial molecules. The objective was to determine their interaction patterns with InhA (PDB ID: 4TRN) using the AutoDock Vina software. Simulations of molecular docking were carried out using a grid cel

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Jain, Gaurav, and Saleem Naik. "An Unusual Case of Isolated Tubercular Splenic Abscess Treated with Anti Tubercular Drugs." New Indian Journal of Surgery 6, no. 3 (2015): 91–92. http://dx.doi.org/10.21088/nijs.0976.4747.6315.6.

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Rama Mohan Reddy, Gunapati, Usha Kiran Prayaga, and Sekhar Babu Bandar. "STEVENS-JOHNSON SYNDROME (SJS) AND TOXIC EPIDERMAL NECROLYSIS (TEN) ASSOCIATED WITH ANTI-TUBERCULAR DRUGS: A CASE REPORT." International Journal of Advanced Research 10, no. 06 (2022): 420–23. http://dx.doi.org/10.21474/ijar01/14905.

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Introduction: Steven-Johnson syndrome (SJS) is an acute reaction that typically involves the skin and mucous membranes which are characterized by damage and flaking of the skin, accompanied by pain, and can cause death. Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin reaction usually caused by medication,which is characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death.SJS and TEN are some of the rare side-effects from Drugs used in Anti-Tubercular Treatment.we repor

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Sinchana Bojamma P.K and Narne Akhil. "Rifampicin-Amlodipine Interaction: A Case Report of Hypertension Exacerbation." Journal of Pharmacovigilance and Drug Research 4, no. 1 (2023): 29–31. http://dx.doi.org/10.53411/jpadr.2023.4.1.6.

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Introduction: Rifampicin, a first-line anti-tubercular therapy drug, is a strong inducer of hepatic cytochrome P450 (CYP). Amlodipine and metoprolol, two anti-hypertensives that are CYP substrates, have the potential to interact pharmacologically with rifampicin. Therefore, individuals with hypertension receiving rifampicin-based anti-tubercular therapy are at risk for worsening hypertension. Case Details: We report a case of a 63-year-old female patient, who developed accelerated hypertension after initiating rifampicin. Later, up to four antihypertensive drugs were administered as part

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Wadhwa, Priyanka, Vaishnavi Modi, Arushi Suri, Krishna D. Barman, Varuna Mallya, and Tanvi Dev. "Ethambutol induced subacute cutaneous lupus erythematosus in an elderly female with co-morbidities." International Journal of Scientific Reports 10, no. 7 (2024): 255–57. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20241667.

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Papulosquamous lesions in an elderly female with multiple co-morbidities often pose diagnostic challenge. We present an interesting case of anti-tubercular treatment (ATT) induced sub-acute cutaneous lupus erythematosus. The patient presented with papulosquamous lesions in generalised distribution, which showed interface dermatitis on histopathology. The serology for anti-nuclear antibodies, anti-Ro and anti-La was positive. The rash resolved spontaneously after stopping all the suspected drugs. Oral provocation was performed with first line anti-tubercular drugs and ethambutol was found to be

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