Relevant bibliographies by topics / Anti–σ factor Interactions

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Anti–σ factor Interactions'

Author: Grafiati
Published: 6 September 2023
Last updated: 31 July 2025

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Journal articles on the topic "Anti–σ factor Interactions"

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Jamithireddy, Anil Kumar, Ashish Runthala та Balasubramanian Gopal. "Evaluation of specificity determinants in Mycobacterium tuberculosis σ/anti-σ factor interactions". Biochemical and Biophysical Research Communications 521, № 4 (2020): 900–906. http://dx.doi.org/10.1016/j.bbrc.2019.10.198.

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Shukla, Jinal, Radhika Gupta, Krishan Gopal Thakur, Rajesh Gokhale та B. Gopal. "Structural basis for the redox sensitivity of theMycobacterium tuberculosisSigK–RskA σ–anti-σ complex". Acta Crystallographica Section D Biological Crystallography 70, № 4 (2014): 1026–36. http://dx.doi.org/10.1107/s1399004714000121.

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The host–pathogen interactions inMycobacterium tuberculosisinfection are significantly influenced by redox stimuli and alterations in the levels of secreted antigens. The extracytoplasmic function (ECF) σ factor σKgoverns the transcription of the serodominant antigens MPT70 and MPT83. The cellular levels of σKare regulated by the membrane-associated anti-σK(RskA) that localizes σKin an inactive complex. The crystal structure ofM. tuberculosisσKin complex with the cytosolic domain of RskA (RskAcyto) revealed a disulfide bridge in the −35 promoter-interaction region of σK. Biochemical experiment
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Kwak, Min-Kyu, Han-Bong Ryu, Sung-Hyun Song, Jin-Won Lee та Sa-Ouk Kang. "Anti-σ factor YlaD regulates transcriptional activity of σ factor YlaC and sporulation via manganese-dependent redox-sensing molecular switch in Bacillus subtilis". Biochemical Journal 475, № 13 (2018): 2127–51. http://dx.doi.org/10.1042/bcj20170911.

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YlaD, a membrane-anchored anti-sigma (σ) factor of Bacillus subtilis, contains a HX3CXXC motif that functions as a redox-sensing domain and belongs to one of the zinc (Zn)-co-ordinated anti-σ factor families. Despite previously showing that the YlaC transcription is controlled by YlaD, experimental evidence of how the YlaC–YlaD interaction is affected by active cysteines and/or metal ions is lacking. Here, we showed that the Pyla promoter is autoregulated solely by YlaC. Moreover, reduced YlaD contained Zn and iron, while oxidized YlaD did not. Cysteine substitution in YlaD led to changes in i
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Anthony, Jennifer R., Jack D. Newman та Timothy J. Donohue. "Interactions Between the Rhodobacter sphaeroides ECF Sigma Factor, σ E , and its Anti-sigma Factor, ChrR". Journal of Molecular Biology 341, № 2 (2004): 345–60. http://dx.doi.org/10.1016/j.jmb.2004.06.018.

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Wettstadt, Sarah, Francisco J. Marcos-Torres, Joaquín R. Otero-Asman, Alicia García-Puente, Álvaro Ortega та María A. Llamas. "Bacterial TonB-dependent transducers interact with the anti-σ factor in absence of the inducing signal protecting it from proteolysis". PLOS Biology 22, № 12 (2024): e3002920. https://doi.org/10.1371/journal.pbio.3002920.

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Competitive bacteria like the human pathogen Pseudomonas aeruginosa can acquire iron from different iron carriers, which are usually internalized via outer membrane TonB-dependent receptors (TBDRs). Production of TBDRs is promoted by the presence of the substrate. This regulation often entails a signal transfer pathway known as cell-surface signaling (CSS) that involves the TBDR itself that also functions as transducer (and is thus referred to as TBDT), a cytoplasmic membrane-bound anti-σ factor, and an extracytoplasmic function σ (σECF) factor. TBDTs contain an extra N-terminal domain known a
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Cartagena, Alexis Jaramillo, Amy B. Banta, Nikhil Sathyan та ін. "Structural basis for transcription activation by Crl through tethering of σS and RNA polymerase". Proceedings of the National Academy of Sciences 116, № 38 (2019): 18923–27. http://dx.doi.org/10.1073/pnas.1910827116.

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In bacteria, a primary σ-factor associates with the core RNA polymerase (RNAP) to control most transcription initiation, while alternative σ-factors are used to coordinate expression of additional regulons in response to environmental conditions. Many alternative σ-factors are negatively regulated by anti–σ-factors. In Escherichia coli, Salmonella enterica, and many other γ-proteobacteria, the transcription factor Crl positively regulates the alternative σS-regulon by promoting the association of σS with RNAP without interacting with promoter DNA. The molecular mechanism for Crl activity is un
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Thakur, Krishan Gopal, Anagha Madhusudan Joshi та B. Gopal. "Structural and Biophysical Studies on Two Promoter Recognition Domains of the Extra-cytoplasmic Function σ Factor σC from Mycobacterium tuberculosis". Journal of Biological Chemistry 282, № 7 (2006): 4711–18. http://dx.doi.org/10.1074/jbc.m606283200.

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σ factors are transcriptional regulatory proteins that bind to the RNA polymerase and dictate gene expression. The extracytoplasmic function (ECF) σ factors govern the environment dependent regulation of transcription. ECF σ factors have two domains σ2 and σ4 that recognize the -10 and -35 promoter elements. However, unlike the primary σ factor σA, the ECF σ factors lack σ3, a region that helps in the recognition of the extended -10 element and σ1.1, a domain involved in the autoinhibition of σA in the absence of core RNA polymerase. Mycobacterium tuberculosis σC is an ECF σ factor that is ess
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Karlinsey, Joyce E., and Kelly T. Hughes. "Genetic Transplantation: Salmonella enterica Serovar Typhimurium as a Host To Study Sigma Factor and Anti-Sigma Factor Interactions in GeneticallyIntractable Systems." Journal of Bacteriology 188, no. 1 (2006): 103–14. http://dx.doi.org/10.1128/jb.188.1.103-114.2006.

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ABSTRACT In Salmonella enterica serovar Typhimurium,σ 28 and anti-sigma factor FlgM are regulatory proteins crucial for flagellar biogenesis and motility. In this study, we used S. enterica serovar Typhimurium as an in vivo heterologous system to study σ28 and anti-σ28 interactions in organisms where genetic manipulation poses a significant challenge due to special growth requirements. The chromosomal copy of the S. enterica serovar Typhimurium σ28 structural gene fliA was exchanged with homologs of Aquifex aeolicus (an extreme thermophile) and Chlamydia trachomatis (an obligate intracellular
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Cavaliere, Paola, та Françoise Norel. "Recent advances in the characterization of Crl, the unconventional activator of the stress sigma factor σS/RpoS". Biomolecular Concepts 7, № 3 (2016): 197–204. http://dx.doi.org/10.1515/bmc-2016-0006.

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AbstractThe bacterial RNA polymerase (RNAP) holoenzyme is a multisubunit core enzyme associated with a σ factor that is required for promoter-specific transcription initiation. Besides a primary σ responsible for most of the gene expression during active growth, bacteria contain alternative σ factors that control adaptive responses. A recurring strategy in the control of σ factor activity is their sequestration by anti-sigma factors that occlude the RNAP binding determinants, reducing their activity. In contrast, the unconventional transcription factor Crl binds specifically to the alternative
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Ho, Khang, та Rasika M. Harshey. "Membrane-associated σ factors disrupt rRNA operon clustering in Escherichia coli". PLOS Biology 23, № 4 (2025): e3003113. https://doi.org/10.1371/journal.pbio.3003113.

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Chromosomal organization in Escherichia coli as examined by Hi-C methodology indicates that long-range interactions are sparse. Yet, spatial co-localization or “clustering” of 6/7 ribosomal RNA (rrn) operons distributed over half the 4.6 Mbp genome has been captured by two other methodologies—fluorescence microscopy and Mu transposition. Our current understanding of the mechanism of clustering is limited to mapping essential cis elements. To identify trans elements, we resorted to perturbing the system by chemical and physical means and observed that heat shock disrupts clustering. Levels of σ
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Dissertations / Theses on the topic "Anti–σ factor Interactions"

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Castro, Ana N. "The role of the anti-σ factor RsiV in stress response in Clostridium difficile and Bacillus subtilis". Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6069.

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Extra Cytoplasmic Function (ECF) σ factors are a diverse family of alternative σ factors that allow bacteria to sense and respond to changes in the environment. σV is an ECF σ factor found primarily in low GC Gram-positive bacteria and is required for lysozyme resistance in several opportunistic pathogens. In the absence of lysozyme, σV is inhibited by the anti-σ factor RsiV. In response to lysozyme, RsiV is degraded via the process of Regulated Intramembrane Proteolysis (RIP). RIP is initiated by cleavage of RsiV at site-1 which allows the intramembrane protease RasP to cleave RsiV within the
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Echeverry, Castano Estefania. "Novel neuroimmune interactions in the context of neuropathic pain and anti-inflammatory modulation with Transforming Growth Factor-ß1." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117099.

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Neuropathic pain is a debilitating problem affecting millions of people worldwide. This condition affects the quality of life and bears a substantial economic burden on society. Current drug treatments are often inadequate to treat this type of chronic pain, as they provide limited relief and are often accompanied with many undesired and difficult to manage side effects. It is imperative thus, to find new treatments that target alternative mechanisms from the currently approved drugs.The pathogenesis of neuropathic pain is very complex and involves structural, physiological and pharmacological
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Letourneur, Didier. "Polymères fonctionnels phosphorylés : interactions biospécifiques avec des protéines humaines, anticorps anti-adn, antiphospholipides et facteurs de transcription." Paris 13, 1988. http://www.theses.fr/1988PA132010.

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Des résines dérivées du polystyrene réticule ont été synthétisées. Ces polymères sont fonctionnalisés par des groupements chimiques analogues à ceux de l'adn et des phospholipides. L'affinité biospécifique de ces resines pour des protèines humaines qui admettent pour substrat l'adn et les phospholipides : anticorps anti adn, anti phospholipide, facteurs de transcription de l'adn. Les anticorps qui sont présents dans le sang des patients atteints de lupus érythemateux dissemine (l. E. D) ont montré une affinité spécifique tres élevée pour les dérivés fonctionnels du polystyrene;ces interactions
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Jamithireddy, Anil Kumar. "Biophysical Studies on Mycobacterium Tuberculosis σ Factor – Regulatory Protein Complexes". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4170.

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Adaptation to external environmental conditions is essential for the survival of a bacterial cell. Bacteria have thus evolved multiple mechanisms to sense environmental stimuli and to couple this information into an appropriate cellular response. The cellular response, in its simplest sense involves a change in the cellular content which is achieved by regulating gene expression. Gene expression in bacteria is primarily regulated at the first step, also referred to as transcription initiation. Extensive studies on this mechanism over the past two decades provide a molecular picture of this p
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Shukla, Jinal K. "Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK". Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3904.

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A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host suggests an adaptive mechanism in M. tuberculosis that can cope with a variety of environmental stresses and other host stimuli. Extensive genomic studies and analysis of knock-out phenotypes revealed elaborate cellular machinery in M. tuberculosis that ensures a rapid cellular response to host stimuli. Prominent amongst these are two-component systems and σ factors that ex
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Shukla, Jinal K. "Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK". Thesis, 2013. http://etd.iisc.ernet.in/2005/3904.

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A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host suggests an adaptive mechanism in M. tuberculosis that can cope with a variety of environmental stresses and other host stimuli. Extensive genomic studies and analysis of knock-out phenotypes revealed elaborate cellular machinery in M. tuberculosis that ensures a rapid cellular response to host stimuli. Prominent amongst these are two-component systems and σ factors that ex
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Yunes, Sarah Ann. "The anti-cancer compound, Factor Quinolinone Inhibitor 1, inhibits stable kinetochore-microtubule attachment during mitotic progression." Thesis, 2020. https://hdl.handle.net/2144/41471.

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Factor Quinolinone Inhibitor 1 (FQI1), discovered as a small molecule inhibitor of the transcription factor LSF, causes cell death in many cancer cell lines and inhibits tumor growth in tumor xenografts and an endogenous hepatocellular carcinoma model in mice. Significantly, multiple animal studies have shown minimal to no toxicity after FQI1 treatment, making it a promising potential lead chemotherapeutic for multiple cancer types. In determining how FQI1 causes cancer cell death, it was previously shown that FQI1 treatment, like knockdown of LSF expression by siRNA, produced a mitotic arrest
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Gale, Alexander Douglas. "Interactions of viral and cellular Tumour Necrosis Factor Receptor molecules." Thesis, 2016. http://hdl.handle.net/10453/62384.

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University of Technology Sydney. Faculty of Science.<br>Tumour necrosis factor (TNF) is potent pro-inflammatory and anti-viral cytokine, acting via two cellular receptors, TNFR1 and TNFR2 that induces apoptosis and inflammation. Poxviruses encode homologues of TNF-receptors (viral TNFRs) that independently interact with both TNF, and simultaneously with cellular TNFRs, to subvert TNF-induced anti-viral apoptosis. The vTNFRs are expressed during poxvirus infection and are considered as bona fide virulence factors. The recently discovery of a “Pre-ligand Assembly Domain (PLAD)” within the N-term
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Botha, M. E. (Mariette). "Two-hybrid analysis and attempted expression of elongation factor 1α from the cattle tick, Rhipicephalus microplus". Diss., 2013. http://hdl.handle.net/2263/31568.

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Control of Rhipicephalus microplus is predominantly mediated by the application of acaricides, but the rapid acquisition of resistance by this species and environmental pollution resulting from discarded acaricides, necessitates the discovery of new control measures. Due to the fact that Rhipicephalus spp. are genetically diverse and often have more than one host, it has been difficult to identify a common protective vaccine candidate able to target all species of this genus. Only one anti-tick antigen, Bm86, has been commercialized to date and is sold as GAVAC® and GAVACPlus® in South America
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Books on the topic "Anti–σ factor Interactions"

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Shengelia, Revaz. Modern Economics. Universal, Georgia, 2021. http://dx.doi.org/10.36962/rsme012021.

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Economy and mankind are inextricably interlinked. Just as the economy or the production of material wealth is unimaginable without a man, so human existence and development are impossible without the wealth created in the economy. Shortly, both the goal and the means of achieving and realization of the economy are still the human resources. People have long ago noticed that it was the economy that created livelihoods, and the delays in their production led to the catastrophic events such as hunger, poverty, civil wars, social upheavals, revolutions, moral degeneration, and more. Therefore, the
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Book chapters on the topic "Anti–σ factor Interactions"

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Mandumpal Chacko, Sabu, and Priya Thambi Thekkekara. "Combined Effect of Metformin and Statin." In Metformin - Pharmacology and Drug Interactions. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100894.

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Diabetes mellitus (DM) is considered a risk factor for the development of coronary artery disease (CAD). Metformin, an anti-diabetic drug, has been shown to lower the cardiovascular events in pre-clinical and clinical studies. Many research articles suggests that metformin has a protective effect on CAD beyond its hypoglycemic effects. Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. Statins have been found to be a safe and effective approach to
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Stanley, Margaret A. "Virus-keratinocyte interactions the infectious cycle." In Human Papillornaviruses and Cervical Cancer. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198547969.003.0006.

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Abstract There seems to be little doubt that infection with certain types of HPV, the so-called ‘oncogenic HPVs’ 16, 18, 31, 33, and 35, is the major but not the only risk factor in the subsequent development of cervical cancer (Schiffmann 1992). This has raised the possibility that if one could prevent infection with HPV or treat established HPV infections this would prevent the development of HPV-associated cancer and be an effective anti-cancer strategy. Other chapters in this book address the feasibility of this exercise from the immunological perspective but any understanding of the immun
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Mantovani, A., C. A. Dinarello, and P. Ghezzi. "Antibodies and soluble receptors." In Pharmacology of cytokines. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780198500438.003.0005.

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Abstract Antibodies and soluble receptors provide a strategy for capturing and blocking cytokines before they interact with their receptors. This strategy is conceptually simple. Interestingly, with the exception of serum therapy against toxins and poisons in a distinct though related area, agonist blockade has not received major attention in classical mainstream pharmacology. With the advent of the cytokine era, this picture has changed dramatically. Antibodies are the single anti-cytokine strategy that has been studied most in one human disease, with consistent results. Thus, in a way, anti-
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Sethi Chopra, Dimple, Abhishek Gupta, Dhandeep Singh, and Nirmal Singh. "Anti-Inflammatory Potential of Ginseng for Wound Healing." In Ginseng - Modern Aspects of the Famed Traditional Medicine. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.101167.

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The recovery of skin wounds is a complex biological process involving three basic mechanisms: inflammatory phase, re-epithelialization followed by granulation and tissue remodeling. The interactions between inflammatory cells, fibroblasts, and keratinocytes induce microenvironmental changes at the wound site. Tissue remodeling is initiated by matrix-producing proteins and protease enzymes and collagen fibers in the dermis. A saponin extracted from ginseng, known as ginsenoside, has been shown to accelerate neovascularization in burn wounds in mice. It also increases levels of vascular endothel
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Singh, Mhaveer, Sapna Salar, Rustam Ekbbal, and Dr Gaurav. "CHEMISTRY AND PHARMACOLOGY-BASED EXPLORATION OF NATURAL INGREDIENTS AS ANTI-INFLAMMATORY PHYTOPHARMACEUTICALS." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 9. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn9ch19.

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The abstract presents an overview of the Chemistry and pharmacology-based exploration of natural ingredients as anti-inflammatory phytopharmaceuticals. In the realm of pharmaceutical research, there is growing interest in harnessing the potential of natural ingredients for developing novel anti-inflammatory agents. This abstract delves into the synergy between chemistry and pharmacology to uncover the therapeutic potential of phytopharmaceuticals in combating inflammation. Natural ingredients sourced from plants have a rich history of medicinal use and are increasingly recognized for their ant
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Ozcan, Gul, and Hasan Korkaya. "The Role of HSP70 in Regulation of Breast Cancer Stem Cells and Apoptotic Pathway." In Cell Death Regulation in Pathology [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1009789.

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HSP70 is a molecular chaperone that plays a critical role in normal physiology of the cell and highly activated under pathological conditions such as cancer. It has been well established that HSP70 is implicated in breast cancer development and progression. Highly activated HSP70 has been linked to processes, such as cell proliferation, metastasis, drug resistance, and driving anti-apoptotic pathways. In the Luminal A subtype, HSP70 stabilizes the ESR1 (estrogen receptor 1) and PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) pathways, supporting cell survival, w
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Parijatham Kanchana, S., Prathi Satya Yasaswini, and Rajashekar Chikati. "In Silico Insights into CLEC4g, TD26, and NRF2 as Therapeutic targets in Hepatocellular Carcinoma." In Convergence of Technology & Biology - Transforming Life Sciences. Shanlax Publications, 2025. https://doi.org/10.34293/ctbtls.2025.ch011.

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Hepatocellular carcinoma is the 6th most occurring cancer in the world it causes approximately 8,30,000 deaths every year making it one of the leading reasons for cancer related deaths. In this project, we performed molecular docking to investigate the binding affinities of anti-HCC agents with three selected proteins: C-type lectin domain family 4 member G (CLEC4G), TD26, and Nuclear factor erythroid 2-related factor 2 (NRF2). CLEC4G is involved in immune modulation within the liver, TD26 is involved in tumor progression, and NRF2 plays a crucial role in cellular defense mechanisms. Using HDo
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İnaç, Muhammet Raşit. "Exercise and Immunology." In Training and Physiological Research in Sports in a Digitalizing World. Özgür Yayınları, 2025. https://doi.org/10.58830/ozgur.pub798.c3385.

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This abstract provides a concise overview of the profound and multifaceted interactions between exercise and the human immune system, highlighting their significant implications for overall health and well-being. Regular physical activity is consistently demonstrated to exert a powerful immunomodulatory effect, leading to enhanced immune surveillance and improved host defense mechanisms. Moderate, consistent exercise is associated with beneficial adaptations, including increased natural killer cell activity, optimized cytokine profiles that balance pro- and anti-inflammatory responses, and imp
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Acharya, Sudeshna, Trisha Chakraborty, Rajat Nath, Anupam Das Talukdar, and Rahul Kanti Nath. "Computational Insights into Chrysin as a Potential EGFR Inhibitor for Targeted Therapy in Non-Small Cell Lung Cancer." In A Basic Handbook of Science, Technology and Innovation for Inclusive Development [Volume: 2], 2nd ed. International Academic Publishing House (IAPH), 2025. https://doi.org/10.52756/bhstiid.2025.e02.002.

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Lung cancer remains one of the primary contributors to cancer-related mortality, presenting a major challenge to human health, so it is necessary to explore the essential compound to inhibit lung cancer. It is a major health concern globally, accounting for approximately 1.8 million deaths annually and over 2.2 million new diagnoses each year. Approximately 85% of lung cancer cases are comprised of Non-small cell lung cancer (NSCLC). The high fatality rate is primarily attributed to late-stage diagnosis and treatment resistance. Targeting epidermal growth factor receptor (EGFR) has become a pr
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Conference papers on the topic "Anti–σ factor Interactions"

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Flemming, H. C. "New Aspects in Membrane Biofouling." In CORROSION 2000. NACE International, 2000. https://doi.org/10.5006/c2000-00307.

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Abstract Biofouling can be a limiting factor in the application of membranes in water treatment. Biofouling can be considered as excessive biofilm growth. This process starts with the adhesion of microorganisms wich happens immediately after contact of the raw water with the membrane. It can be assumed that virtually all membrane systems working with nonsterile water carry biofilms which influence the overall separation properties. Only if an individually given threshold of interference is met, "biofouling" occurs. A new anti-fouling strategy can be addressed as "biofilm management", limiting
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McDonnell, T., C. Wincup, V. Ripoll, et al. "PS5:99 Examining the modulatory effects of anti-serine protease antibodies upon factor xa, thrombin and complement interactions." In 11th European Lupus Meeting, Düsseldorf, Germany, 21–24 March 2018, Abstract presentations. Lupus Foundation of America, 2018. http://dx.doi.org/10.1136/lupus-2018-abstract.144.

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Wang, Changchang, Guoyu Wang, Mindi Zhang, and Qin Wu. "Wall-Pressure Fluctuations Inside Attached Cavitation." In ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65501.

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Abstract This study experimentally investigates the statistics of wall-pressure fluctuations and their source inside attached cavitation under different cavity regimes. Experiments were conducted in the divergent section of a convergent-divergent channel at a constant Reynolds number of Re = 7.8 × 105 based on throat height, and different cavitation numbers σ = 1.18, 0.92, 0.82 and 0.78. Four high-frequency unsteady pressure transducers were flushed-mounted in the divergent section downstream the throat where cavitation develops to sample the unsteady pressure signals induced by cavity behavio
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Devine, D. V., and W. F. Rosse. "PLATELET FACTOR H REGULATES THE ACTIVITY OF THE ALTERNATIVE PATHWAY OF COMPLEMENT ON THE SURFACE OF NORMAL AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643979.

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Paroxysmal nocturnal hemoglobinuria (PNH)-is frequently complicated by thrombosis. It has been suggested that the abnormal interactions of PNH platelets with complement contribute to thrombosis. Using purified complement proteins, we have previously demonstrated that the platelets from some patients with PNH do not demonstrate elevated activity of C3bBb, the alternative pathway C3 amplification enzyme complex, even though they lack the C3bBb regulatory protein, decay accelerating factor (DAF). As measured by fluorescence flow cytometry, washed platelets from both normal donors and PNH patients
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Fulcher, C. A., R. A. Houghten, S. de Graaf Mahoney, J. R. Roberts, and T. S. Zimmerman. "SYNTHETIC PEPTIDE PROBES OF FACTOR VIII IMMUNOLOGY AND FUNCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644768.

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In order to develop specific immunologic reagents for mapping functionally important sites on FVIII, we have prepared rabbit polyclonal antibodies against synthetic peptides of FVIII derived from regions along the entire FVIII amino acid sequence. To date, a total of 70 peptides have been synthesized and characterized by amino acid and HPLC analysis. The peptides were coupled to keyhole limpet hemocyanin with glutaraldehyde as a linkage reagent and used to immunize rabbits. Antisera were tested by ELISA assay on polystyrene microtiter plates coated with either the peptide immunogen, or purifie
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Gewirtz, A., W. Y. Xu, B. Rucinski, and S. Niewiarowski. "SELECTIVE INHIBITION OF HUMAN MEGAKARYOCYTOPOIESIS IN VITRO BY HIGHLY PURIFIED PLATELET FACTOR 4." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644621.

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Platelet (plt) factor 4 (PF4) is an alpha granule protein which can modulate T lymphocyte function. T cells may help regulate megakaryocytopoiesis. Therefore, we hypothesized that T cell-PF4 interactions might play a role in autoregulating marrow megakaryocyte (MEG) production. To test this idea, we studied MEG colony formation in plasma clot cultures containing human serum derived solely from pit poor normal AB plasma, enriched hematopoietic progenitor cells (HPC), autologous T cells, and exogenous PF4. Highly purified PF4 (single band on SDS gel) was prepared from outdated human pits by a co
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Croccolo, Dario, Massimiliano De Agostinis, Stefano Fini, et al. "The Influence of Material, Hardness, Roughness and Surface Treatment on the Frictional Characteristics of the Underhead Contact in Socket-Head Screws." In ASME 2018 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/pvp2018-84530.

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The present paper aims at determining the effect of several design and manufacturing parameters on the frictional response of the underhead contact in a bolted joint comprising a socket-head M6 class 12.9 screw. The rationale of the research moves from the need to understand the frictional behavior of screw joints used in machine tools as a means to join roller monoguides with the moving carriages of three-axis tooling units. The experimentation takes into account different underhead materials (Steel, Cast Iron, Aluminum), different roughness levels (Ra = 0.8, 1.6, 3.2), different surface trea
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Schmid, Peter, and Emmanuel de Langre. "Transient Growth Before Coupled-Mode Flutter." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32200.

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Transient growth of energy is known to occur even in stable dynamical systems due to the non-normality of the underlying linear operator. This has been the object of growing attention in the field of hydrodynamic stability, where linearly stable flows may be found to be strongly nonlinearly unstable as a consequence of transient growth. We apply these concepts to the generic case of coupled-mode flutter, which is a mechanism with important applications in the field of fluid-structure interactions. Using numerical and analytical approaches on a simple system with two degrees of freedom and anti
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Nachman, R. L., R. L. Silverstein, and A. S. Asch. "THROMBOSPONDIN: CELL BIOLOGY OF AN ADHESIVE GLYCOPROTEIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644653.

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Thrombospondin (TSP), a multifunctional 450 KD glycoprotein is a secretory product of thrombin stimulated platelets. It is a major component of the platelets alpha granule constituting approximately 3% of total platelet protein. Thrombospondin does not circulate in appreciable concentrations ∽0 100 ng/ml); however, the tissue distribution is broad. In addition to its expression on the membrane of activated platelets, the protein is synthesized by fibroblasts endothelial cells, glial cell smooth muscle cells alveolar pneumocytes mononuclear phagocytes and various tumor cells. TSP is a major con
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Marquerie, G., A. Duperray, G. Uzan, and R. Berthier. "BIOSYNTHETIC PATHWAYS OF THE PLATELET FIBRINOGEN RECEPTOR IN HUMAN MEGAKARYOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642954.

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Interaction between cells and between cells and extracellular matrices are critical for a number of biological processes, including organ development, cell differenciation, cell motility, and the inimune' response. These interactions are mediated by a family of adhesion receptors that recognize short sequences such as Arg-Gly-Asp (RGD). These receptors share similar structural properties. They are heterodimers composed of a and B subunits and sometime express common epitopes. This suggests that the structural and functional relationship of these receptors may result from the transcription of r
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Reports on the topic "Anti–σ factor Interactions"

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Evans, Donald L., Avigdor Eldar, Liliana Jaso-Friedmann, and Herve Bercovier. Streptococcus Iniae Infection in Trout and Tilapia: Host-Pathogen Interactions, the Immune Response Towards the Pathogen and Vaccine Formulation. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7586538.bard.

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The objectives of the BARD proposal were to determine the mechanisms of nonspecific cytotoxic cells (NCC) that are necessary to provide heightened innate resistance to infection and to identify the antigenic determinants in Streptococcus iniae that are best suited for vaccine development. Our central hypothesis was that anti-bacterial immunity in trout and tilapia can only be acquired by combining "innate" NCC responses with antibody responses to polysaccharide antigens. These Objectives were accomplished by experiments delineated by the following Specific Aims: Specific aim (SA) #1 (USA) "Clo
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Citovsky, Vitaly, and Yedidya Gafni. Viral and Host Cell Determinants of Nuclear Import and Export of the Tomato Yellow Leaf Curl Virus in Tomato Plants. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7585200.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. In Israel, where TYLCV epidemics have been recorded since the 1960' s, this viral disease is well known and has been of economic significance ever since. In recent years, TYLCV outbreaks also occurred in the "New World" - Cuba, The Dominican Republic, and in the USA, in Florida, Georgia and Louisiana. Thus, TYLCV substantially hinders tomato growth throughout the world. Surprisingly, however, little is known about the molecular mechanisms of TYLCV inter
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Yedidia, I., H. Senderowitz, and A. O. Charkowski. Small molecule cocktails designed to impair virulence targets in soft rot Erwinias. United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134165.bard.

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Chemical signaling between beneficial or pathogenic bacteria and plants is a central factor in determining the outcome of plant-microbe interactions. Pectobacterium and Dickeya (soft rot Erwinias) are the major cause of soft rot, stem rot, and blackleg formed on potato and ornamentals, currently with no effective control. Our major aim was to establish and study specific bacterial genes/proteins as targets for anti-virulence compounds, by combining drug design tools and bioinformatics with experimental work. The approach allowed us to identify and test compounds (small molecules) that specific
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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist bioph
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