Academic literature on the topic 'Antimalarials'

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Journal articles on the topic "Antimalarials"

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Kwofie, Samuel K., Emmanuel Broni, Bismark Dankwa, et al. "Review of Atypical Organometallic Compounds as Antimalarial Drugs." Journal of Chemistry 2020 (May 20, 2020): 1–9. http://dx.doi.org/10.1155/2020/9414093.

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Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in compa
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Esdaile, John M. "The Efficacy of Antimalarials in Systemic Lupus Erythematosus." Lupus 2, no. 1_suppl (1993): 3–8. http://dx.doi.org/10.1177/0961203393002001021.

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The use of antimalarial drugs to treat systemic lupus erythematosus (SLE) is reviewed regarding their value in SLE of mild-to-moderate disease activity, as corticosteroid-sparing agents, and as an adjunctive therapy in severe SLE. A retrospective controlled study of a variety of antimalarials and a randomized discontinuation trial of hydroxychloroquine support the considerable clinical belief that antimalarials are of benefit in mild-to-moderate SLE. Anecdotal reports and the opinion of experienced clinicians suggest that antimalarials permit the use of lower doses of corticosteroids. No contr
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Edgar, Muhindo. "Combating Malaria with Plant-Based Antimalarials: A Comparative Study." Research Output Journal of Public Health and Medicine 4, no. 2 (2024): 18–22. http://dx.doi.org/10.59298/rojphm/2024/421822.

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Malaria remains a leading global health threat, especially in low-income regions such as Sub-Saharan Africa, where traditional antimalarial treatments face increasing challenges due to drug resistance. Artemisinin-based combination therapies (ACTs) have long been the primary frontline treatment; however, escalating resistance in Plasmodium species has prompted researchers to investigate alternative solutions, including plant-derived antimalarials. This study examines the efficacy and safety of plant-based antimalarial compounds, particularly Artemisia annua, compared to synthetic drugs, consid
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Evans, Daniel R., Colleen R. Higgins, Sarah K. Laing, Phyllis Awor, and Sachiko Ozawa. "Poor-quality antimalarials further health inequities in Uganda." Health Policy and Planning 34, Supplement_3 (2019): iii36—iii47. http://dx.doi.org/10.1093/heapol/czz012.

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Abstract Substandard and falsified medications are a major threat to public health, directly increasing the risk of treatment failure, antimicrobial resistance, morbidity, mortality and health expenditures. While antimalarial medicines are one of the most common to be of poor quality in low- and middle-income countries, their distributional impact has not been examined. This study assessed the health equity impact of substandard and falsified antimalarials among children under five in Uganda. Using a probabilistic agent-based model of paediatric malaria infection (Substandard and Falsified Ant
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Agbo, Chinonyelum Emmanuel, Uzochukwu Emmanuel Chima, Sunday Chibueze Ogbobe, Faith Olanrewaju Omotayo, and Success Chekwubechukwu David. "Transdermal antimalarial drug delivery to improve poor adherence to antimalarials: A new light at the end of the tunnel." American Journal of Biopharmacy and Pharmaceutical Sciences 3 (December 2, 2023): 4. http://dx.doi.org/10.25259/ajbps_14_2023.

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Malaria, a perilous disease caused by Plasmodium parasites and characterized by a substantial mortality rate, has persistently posed as a global health challenge. Conventional antimalarial formulations, although effective, grapple with issues surrounding their bioavailability and palatability, and potentially hampering patient adherence and inadvertently fueling drug resistance and poor treatment outcomes. This paper meticulously delves into the predicaments associated with prevailing antimalarial delivery methods – oral, intravenous, and intramuscular. The paper navigates through the compelli
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Zieliński, Ewa, Marek Kowalczyk, Karolina Osowiecka, Łukasz Klepacki, Łukasz Dyśko, and Katarzyna Wojtysiak. "The Problem of Antimalarial-Drug Abuse by the Inhabitants of Ghana." Medicina 59, no. 2 (2023): 257. http://dx.doi.org/10.3390/medicina59020257.

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Introduction: Malaria is still a huge social and economic health problem in the world. It especially affects the developing countries of Africa. A particular problem is the misuse and abuse of over-the-counter antimalarials. This problem could lead to the emergence of drug-resistant strains and the subsequent elimination of more antimalarials from the list of effective antimalarials in Ghana. Methods: During the implementation of the study, an original questionnaire was used to collect data among Ghanaians on their knowledge of malaria, attitude towards antimalarials and their use of antimalar
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Opsenica, Igor, Dejan Opsenica, Milka Jadranin, et al. "On peroxide antimalarials." Journal of the Serbian Chemical Society 72, no. 12 (2007): 1181–90. http://dx.doi.org/10.2298/jsc0712181o.

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Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synt
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Heppner, DG, PE Hallaway, GJ Kontoghiorghes, and JW Eaton. "Antimalarial properties of orally active iron chelators." Blood 72, no. 1 (1988): 358–61. http://dx.doi.org/10.1182/blood.v72.1.358.358.

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Abstract The appearance of widespread multiple drug resistance in human malaria has intensified the search for new antimalarial compounds. Metal chelators, especially those with high affinity for iron, represent one presently unexploited class of antimalarials. Unfortunately the use of previously identified chelators as antimalarials has been precluded by their toxicity and, in the case of desferrioxamine, the necessity for parenteral administration. The investigators now report that a new class of orally active iron chelators, namely the derivatives of alpha- ketohydroxypyridines (KHPs), are
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Heppner, DG, PE Hallaway, GJ Kontoghiorghes, and JW Eaton. "Antimalarial properties of orally active iron chelators." Blood 72, no. 1 (1988): 358–61. http://dx.doi.org/10.1182/blood.v72.1.358.bloodjournal721358.

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The appearance of widespread multiple drug resistance in human malaria has intensified the search for new antimalarial compounds. Metal chelators, especially those with high affinity for iron, represent one presently unexploited class of antimalarials. Unfortunately the use of previously identified chelators as antimalarials has been precluded by their toxicity and, in the case of desferrioxamine, the necessity for parenteral administration. The investigators now report that a new class of orally active iron chelators, namely the derivatives of alpha- ketohydroxypyridines (KHPs), are potent an
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Zheng, Dan, Tingting Liu, Shasha Yu, Zhilong Liu, Jing Wang, and Ying Wang. "Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives." Tropical Medicine and Infectious Disease 9, no. 9 (2024): 223. http://dx.doi.org/10.3390/tropicalmed9090223.

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Artemisinin is an endoperoxide sesquiterpene lactone isolated from Artemisia annua and is often used to treat malaria. Artemisinin’s peroxide bridge is the key structure behind its antimalarial action. Scientists have created dihydroartemisinin, artemether, artesunate, and other derivatives preserving artemisinin’s peroxide bridge to increase its clinical utility value. Artemisinin compounds exhibit excellent efficacy, quick action, and minimal toxicity in malaria treatment and have greatly contributed to malaria control. With the wide and unreasonable application of artemisinin-based medicine
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Dissertations / Theses on the topic "Antimalarials"

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Meurer, Michael. "Childhood Discoid Lupus erythematosus and Antimalarials." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135574.

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Al-Tayib, Yousuf A. "Oxidative hepatic metabolism of cinchona antimalarials." Thesis, University of Bradford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304177.

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Rajab, M. "Investigating calcium channel blockers as antimalarials." Thesis, University of Salford, 2018. http://usir.salford.ac.uk/47791/.

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The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford identified calcium channel blockers (CCBs) as potential antimalarial agents. A growing body of evidence has demonstrated the importance of calcium within the <I>Plasmodium</I> life cycle. Studies have shown CCBs and calmodulin inhibitors to exhibit antimalarial activity. The research carried out in this project aims to evaluate the antimalarial efficacy
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Meurer, Michael. "Childhood Discoid Lupus erythematosus and Antimalarials." Karger, 2003. https://tud.qucosa.de/id/qucosa%3A27661.

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Nicoleti, Nélio Henrique [UNESP]. "Estrutura eletrônica de materiais orgânicos: moléculas antimalariais de sulfonamidas e anilinoquinolinas." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/88499.

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Made available in DSpace on 2014-06-11T19:23:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-05-11Bitstream added on 2014-06-13T20:10:54Z : No. of bitstreams: 1 nicoleti_nh_me_bauru.pdf: 1244120 bytes, checksum: 82b0fc15919f6c3214248fe48efec3e6 (MD5)<br>Neste trabalho estudamos dois grupos de moléculas: as anilinoquinolinas e as sulfonamidas, inibidores do Plasmodium causador da malária, com o objetivo de correlacionar a estrutura eletrônica com a atividade antimalarial. Em nossas buscas utilizamos métodos empíricos e semi-empíricos para o estudo conformacional e obtenção dos descr
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Zindrou, Sherwan. "Molecular diagnosis of drug resistance in Plasmodium falciparum and virulence factors in Entamoeba histolytica /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4304-4/.

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Hayes, Daniel Joseph. "Developing age-based dosing regimens for antimalarials." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570625.

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Introduction. Age-based dosing of antimalarials is a widely used alternative to weight-based dosing practices. However, it is rarely taken into account in the drug development phase and standardized methods to devise age-based proxies that optimize the effectiveness and safety of antimalarial drugs do not exist. This has contributed to the variation in existing age-based regimens for antimalarials, at times resulting in poor, but widely-used regimens. Inaccurate dosing poses a threat to the individual (treatment failure, adverse effects) and the population (emergence and spread of resistance).
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Molyneaux, Carrie-Anne. "Antimalarials based on the arylpiperazine privileged substructure." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/6342.

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Includes bibliographical references (leaves 118-124).<br>Based on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain. In other studies, 8-hydroxy-2-(di-n-propylamino)tetralin (8-0H-DPAT) has been identified as a potential antimalarial agent for the inhibition of the 5-hydroxytryptamine type 1A receptor in Plasmodium falciparum. A number of arylpiperazines are also known to target this receptor in oth
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Tan, Bee San Fleckenstein Lawrence L. "Population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/442.

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Duraisingh, Manoj Theodore. "Characterisation of resistance to artemisinin in Plasmodium falciparum." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322662.

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Books on the topic "Antimalarials"

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Ciach, Michelle. Novel antimalarials and sensitizing agents. National Library of Canada, 2002.

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Silikas, Nikolaos. Rational drug design of protoberberine antimalarials. University of Manchester, 1995.

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Drugs for Neglected Diseases Initiative. The successful development of a fixed dose combination of artesunate plus amodiaquine antimalarial: Pioneering ways of working through innovative partnerships 2002-2015. DNDi, 2015.

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Silvia, Blair, ed. Plantas antimaláricas: Una revisión bibliográfica. Editorial Universidad de Antioquia, 1991.

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Kiang, Tony K. L., Kyle John Wilby, and Mary H. H. Ensom. Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-10527-7.

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Depoortere, Evelyn. Compliance to the combination of sulfadozine-pyrimethamine, and artesunate: Maheba Refugee Settlement, Zambia : final report. Epicentre, 2002.

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Jan, Bruce-Chwatt Leonard, ed. Chemotherapy of malaria. 2nd ed. World Health Organization, 1986.

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Vanuatu. Department of Health. Malaria Control Unit. Malaria handbooks for health workers in Vanuatu. Malaria Control Unit Department of Health, 1995.

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Li, Qigui. Antimalarial drugs: Age of the artemisinins. Nova Science, 2010.

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South Africa) TPS Drug Information Centre (Pretoria. Malaria prophylaxis: The South African viewpoint. Dept. of National Health and Population Development, 1993.

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Book chapters on the topic "Antimalarials"

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Tull, Thomas, and Mark Goodfield. "Antimalarials." In Handbook of Systemic Drug Treatment in Dermatology, 3rd ed. CRC Press, 2022. http://dx.doi.org/10.1201/9781003016786-7.

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Champagne, Trevor. "Antimalarials." In Litt's Drug Eruption & Reaction Manual, 31st ed. CRC Press, 2025. https://doi.org/10.1201/9781003569756-1507.

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Henry, David W. "Acridine Antimalarials." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch19.

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Stocks, Paul A., Kaylene J. Raynes, and Stephen A. Ward. "Novel Quinoline Antimalarials." In Antimalarial Chemotherapy. Humana Press, 2001. https://doi.org/10.1007/978-1-59259-111-4_13.

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Tilley, Leann, Paul Loria, and Mick Foley. "Chloroquine and Other Quinoline Antimalarials." In Antimalarial Chemotherapy. Humana Press, 2001. https://doi.org/10.1007/978-1-59259-111-4_6.

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Kiang, Tony K. L., Kyle John Wilby, and Mary H. H. Ensom. "Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials." In Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10527-7_6.

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Bhattacharjee, Mrinal K. "Antifungals, Antimalarials, and Antivirals." In Chemistry of Antibiotics and Related Drugs. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40746-3_8.

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Bhattacharjee, Mrinal K. "Antifungals, Antimalarials, and Antivirals." In Chemistry of Antibiotics and Related Drugs. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-07582-7_8.

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Kiang, Tony K. L., Kyle John Wilby, and Mary H. H. Ensom. "Pharmacokinetic Drug Interactions Affecting Antimalarials." In Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10527-7_4.

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Kiang, Tony K. L., Kyle John Wilby, and Mary H. H. Ensom. "Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials." In Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10527-7_3.

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Conference papers on the topic "Antimalarials"

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Dreve, Simina, Iren Kacso, Adriana Popa, et al. "Chitosan-based nanocarriers for antimalarials." In PROCESSES IN ISOTOPES AND MOLECULES (PIM 2011). AIP, 2012. http://dx.doi.org/10.1063/1.3681956.

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Desai, Krisha, Majid Zeidi, Hee Joo Kim, and Victoria P. Werth. "II-09 Immunologic properties of cutaneous lupus erythematosus (CLE) patients refractory to antimalarials compared to patients that respond to antimalarials." In LUPUS 21ST CENTURY 2018 CONFERENCE, Abstracts of the Fourth Biannual Scientific Meeting of the North and South American and Caribbean Lupus Community, Armonk, New York, USA, September 13 – 15, 2018. Lupus Foundation of America, 2018. http://dx.doi.org/10.1136/lupus-2018-lsm.108.

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Silva, Gabriela D. da, Piero Bagnaresi, and Rodrigo L. O. R. Cunha. "Organoselenium functionalized nitrogen heterocycles: a proposition for new antimalarials." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20131014142313.

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Wang, F., W. Zhang, X. Feng, and L. Sun. "FRI0320 Antimalarials protective effects in systemic lupus erythematosus in china." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.3073.

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Cardoso, Isabella de Mello, Jannine Farias Bellini Leite, Luísa Camargo Thomé, et al. "Major OCT Findings in SLE Patients Using Antimalarials: A Prospective Study." In XLI Congresso Brasileiro de Reumatologia. Sociedade Brasileira de Reumatologia, 2024. https://doi.org/10.47660/cbr.2024.2166.

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Ma, Wenchuan, James Lutsko, Jeffrey Rimer, and Peter Vekilov. "Antagonistic Cooperativity between Antimalarials Controlling Hematin Crystallization by Attenuation of Step Pinning." In Goldschmidt2020. Geochemical Society, 2020. http://dx.doi.org/10.46427/gold2020.1689.

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Asghari-Khiavi, Mehdi, Jitraporn Vongsvivut, Adam Mechler, et al. "Vibrational Spectroscopy Study of the Interaction of Quinoline Antimalarials with Ferriprotoporphyrin IX." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482885.

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Canhão, H., JE Fonseca, JC Teixeira Costa, JA Pereira Silva, and M. Viana Queiroz. "FRI0107 Toxicity of antimalarials in the treatment of portuguese patients with systemic lupus erythematosus." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.142.

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DUBE, PRITAM, NITIN JAIN, and PRADEEP DESHMUKH. "Development of Triazine-4,6-diamines derivatives as potential Antimalarials: In-Silico Analysis." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04805.

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Pons-Estel, G., D. Wojdyla, M. Ugarte-Gil, et al. "192 Protective effect of antimalarials on the risk of damage accrual in systemic lupus erythematosus." In LUPUS 2017 & ACA 2017, (12th International Congress on SLE &, 7th Asian Congress on Autoimmunity). Lupus Foundation of America, 2017. http://dx.doi.org/10.1136/lupus-2017-000215.192.

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Reports on the topic "Antimalarials"

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Dhawan, B. N. Evaluation of New Antimalarials. Development of New Antimalarial Drugs. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada242409.

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Rayhim, Rayhana, and Jeannie S. Strobl. Augmentation of the Differentiation Response to Antitumor Antimalarials. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada432050.

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Murphy, Kevin. Design and Synthesis of Novel Chloroquine-based Antimalarials. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.2619.

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Avery, Mitchell A. Directed Synthesis of New Antimalarials Using Computer Aided Drug Design. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada303867.

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Avery, Mitchell A. Directed Synthesis of New Antimalarials using Computer Aided Drug Design. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada304919.

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San Pedro, Ekaterina Ellyce. A brief historical overview of the antimalarials chloroquine and artemisinin: An investigation into their mechanisms of action and discussion on the predicament of antimalarial drug resistance. Iowa State University, 2021. http://dx.doi.org/10.31274/cc-20240624-10.

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Ager, Arba L. Evaluation of Antimalarial Agents. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada382495.

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Basagoitia, Andrea. Do home- or community-based programmes for treating malaria improve health outcomes? SUPPORT, 2017. http://dx.doi.org/10.30846/170313.

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Prompt access to diagnosis and treatment with effective antimalarial drugs is a central component of malaria control. Home- or community-based programmes for managing malaria are one strategy that has been proposed to overcome the geographical barrier to malaria treatment. In these programmes people living in rural settings, such as mothers, volunteers, or community health workers, are trained to recognise fever and provide antimalarial medicines at a low cost or for free.
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Kokpol, Sirirat. Relationships between biological activity and molecular properties of artemisinin compounds. Chulalongkorn University, 2001. https://doi.org/10.58837/chula.res.2001.38.

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Relationships between biological activity and molecular properties of 68 antimalarial artemisinin compounds were investigated in the quantitative manner. All compounds were geometrically optimized at the HF/3-21G level. Totally 102 molecular properties covering hydrophobicity, polarizability, electronic, and steric parameters were calculated from the optimized structures. The activities against 2 different strains of malarial parasites, D-6 and W-2, were taken from the literatures. Statistical analyses were performed to find the relationships between the activities and the calculated molecular
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Hoffman, Marshall M. Design, Synthesis and Testing of Novel Antimalarial. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada452979.

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