Academic literature on the topic 'Antioxidant abuse'

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Journal articles on the topic "Antioxidant abuse"

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Berríos-Cárcamo, Pablo, Mauricio Quezada, María Elena Quintanilla, et al. "Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules." Antioxidants 9, no. 9 (2020): 830. http://dx.doi.org/10.3390/antiox9090830.

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Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, all drugs of abuse promote the activation of the brain reward system, with lasting neurobiological consequences that potentiate subsequent consumption. Recent evidence shows that the brain displays marked oxidative stress and neuroinflammation following chronic drug consumption. Brain oxidative stress and neuroinflammation disrupt glutamate homeostasis by impairing synaptic an
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Ige, A. O., D. T. Oluwole, M. O. Olaoye, and E. O. Adewoye. "Testicular function following oral exposure to Tramadol and Cannabis sativa ethanol extracts in male Wistar rats." Research Journal of Health Sciences 8, no. 2 (2020): 63–72. http://dx.doi.org/10.4314/rejhs.v8i2.2.

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Objective: Substance abuse is a global challenge. This study investigated the effects of two commonly abused substances, tramadol and/or Cannabis sativa ethanol extracts (ECS), on testicular function in Wistar male rats.Methods: Twenty-animals were equally divided into 4groups that received 0.9%NaCl (0.2ml), tramadol (40mg/kg), ECS (2mg/kg) and tramadol + ECS for 30days, respectively (daily p.o). Following anesthesia, blood samples were obtained and serum testosterone was determined. Testes and epididymis were harvested and weighed. Sperm motility, viability and counts were evaluated in the ep
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Saribal, Devrim, Fatma Sinem Hocaoglu-Emre, Fulya Karaman, Hasan Mırsal, and Mehmet Can Akyolcu. "Trace Element Levels and Oxidant/Antioxidant Status in Patients with Alcohol Abuse." Biological Trace Element Research 193, no. 1 (2019): 7–13. http://dx.doi.org/10.1007/s12011-019-01681-y.

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Ramirez, Servio H., Raghava Potula, Shongshan Fan, et al. "Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells." Journal of Cerebral Blood Flow & Metabolism 29, no. 12 (2009): 1933–45. http://dx.doi.org/10.1038/jcbfm.2009.112.

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Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high abuse liability and long-lasting neurotoxic effects. Recent studies in animal models have indicated that METH can induce impairment of the blood–brain barrier (BBB), thus suggesting that some of the neurotoxic effects resulting from METH abuse could be the outcome of barrier disruption. In this study, we provide evidence that METH alters BBB function through direct effects on endothelial cells and explore possible underlying mechanisms leading to endothelial injury. We report that METH increases BBB permeabi
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Duranti, Guglielmo, Roberta Ceci, Luigi Di Luigi, et al. "Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity." International Journal of Environmental Research and Public Health 18, no. 19 (2021): 9962. http://dx.doi.org/10.3390/ijerph18199962.

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Background: The phosphodiesterase type 5 inhibitor (PDE5I) tadalafil, in addition to its therapeutic role, has shown antioxidant effects in different in vivo models. Supplementation with antioxidants has received interest as a suitable tool for preventing or reducing exercise-related oxidative stress, possibly leading to the improvement of sport performance in athletes. However, the use/abuse of these substances must be evaluated not only within the context of amateur sport, but especially in competitions where elite athletes are more exposed to stressful physical practice. To date, very few h
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Arto, Sastha Sugih, and Reynatha C. A. Pangsibidang. "Review of natural antioxidant plants to overcome the neurotoxic effects of methamphetamine." Pharmacy Education 24, no. 6 (2024): 59–72. http://dx.doi.org/10.46542/pe.2024.246.5972.

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Background: Methamphetamine (METH) is a psychostimulant substance known for its substantial abuse potential and neurotoxic properties. METH is a second-line drug in certain conditions such as Attention Deficit Hyperactivity Disorder (ADHD), severe obesity, or narcolepsy. Objective: This study aims to compare natural plant antioxidants to overcome neurotoxicity caused by methamphetamine. Method: The authors used a literature review method and collected articles from "PubMed", "Google Scholar", "ScienceDirect", "Scopus" from 2010 - 2023 without excluding old works that are often cited and truste
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Baliño, Pablo, Ricard Romero-Cano, and María Muriach. "Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome." International Journal of Molecular Sciences 22, no. 2 (2021): 807. http://dx.doi.org/10.3390/ijms22020807.

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Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects of ethanol abuse and metabolic syndrome at a central level have not yet been elucidated in detail. Thus, this work aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Seven-week-old male control (B6.V-Lep
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Deka, Kamala, Anju Moni Rabha, and Mainak Roy. "Association of vitamin D and antioxidant enzyme levels in patients with delirium tremens: A case control study." Industrial Psychiatry Journal 33, no. 2 (2024): 285–91. https://doi.org/10.4103/ipj.ipj_25_24.

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Background: Global alcohol consumption poses a serious threat to humankind. It is estimated that between 5% and 7% of Indian adults struggle with alcohol abuse. Alcoholism is associated with a number of disorders, impacting different organ systems and nutritional status, including symptoms of withdrawal that can vary in severity from moderate symptoms to delirium tremens (DT). An increase in oxidative stress in the body is linked to alcohol withdrawal. Aim: This study aimed to evaluate the role of vitamins with antioxidant properties on oxidative stress caused by the severe alcohol withdrawal
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Sandoval, Cristian, Jorge Farías, Mauricio Zamorano, and Christian Herrera. "Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review." Antioxidants 11, no. 3 (2022): 564. http://dx.doi.org/10.3390/antiox11030564.

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Several studies have shown that blood vitamin levels are low in alcoholic patients. In effect, alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many fatal diseases, such as cancer and liver cirrhosis. The alcohol effects in the liver can be prevented by antioxidant mechanisms, which induces enzymatic as well as other nonenzymatic pathways. The effectiveness of several antioxidants has been evaluated. However, these studies have been accompanied by uncertainty as mixed results were reported. Thus, the aim of the present review article was to examine the curren
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C.O, Akintayo, Olukiran O.S, Ayodele M.J, and Karga S.V. "Administration of Cannabinol and Alcohol Altered the Liver Enzymes, Lipid Profile and Antioxidant Status of Male Wistar Rats." Journal of Drug Metabolism & Toxicology 14, no. 1 (2023): 5. https://doi.org/10.35248/2157-7609.23.14.271.

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Background: Cannabis and alcohol increasingly gain legalized status in many countries, the popularity and prevalence of use continues to grow. Objective: This study was designed to investigate their effects on liver enzymes and lipid profile of rats. Methods: Twenty five male rats were divided into 5 groups; group 1 was given distilled water; groups 2, 3, 4 and 5 rats were treated with 5% methanol, 25% alcohol, 10 mg/kg of cannabinol, 25% alcohol and 10 mg/kg of cannabinol p.o for 8 weeks respectively. Statistical analysis was done using the ANOVA. Results: The serum concentrations of AST and
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Dissertations / Theses on the topic "Antioxidant abuse"

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Ащаулова, Г. А. "Антиоксидантна терапія в корекції оксидативного стресу у хворих на артеріальну гіпертензію та ожиріння на тлі цукрового діабету". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47146.

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Вступ. Артеріальна гіпертензія (АГ) і ожиріння (Ож) мають спільні нейрогуморальні патогенетичні механізми, що проявляються ремоделюванням серця та судинної стінки. Провідним механізмом є оксидантний стрес (ОС). Використання препаратів корегуючих антиоксидантні порушення, позитивно впливає на динаміку розвитку серцево-судинної патології. Мета роботи. Оцінка ступеня ОС і стану антиоксидантного захисту (АОЗ) у пацієнтів із АГ та Ож на тлі цукрового діабету (ЦД) в динаміці лікування із застосуванням мексидолу та L-аргініну.
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Books on the topic "Antioxidant abuse"

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Koottathep, Surangchit. Studies on chain-breaking antioxidants: 1. Use of the 'TRAP' assay to measure peroxyl-radical trapping properties in serum in rheumatoid-arthritis, alcohol abuse and malaria : 2. A modified HPLC method to analyse dehydro- and reduced ascorbic acid in blood. University of Birmingham, 1988.

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Book chapters on the topic "Antioxidant abuse"

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Odeleye, Olalekan E., and Ronald R. Watson. "Effects of Alcohol and Cocaine Abuse on the Antioxidant Systems, Nutritional Status, and Liver Damage." In Liver Pathology and Alcohol. Humana Press, 1991. http://dx.doi.org/10.1007/978-1-4612-0421-3_18.

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Nomer, Naciye Zeynep. "Myristica Fragrans Houtt." In Medicinal Spices. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359340.6.

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Myristica fragrans Houtt. is an evergreen tree that grows in humid areas. The tree is native to the Indonesian Maluku Islands, and over time, it began to be grown in different parts of the world. It has dark green leaves, yellow and bell-shaped flowers, and drupe fruit with a dark brown seed and red aril. The seed and aril are called nutmeg and mace separately. They are generally used as spices for their aromatic flavor. Nutmeg has been used in various countries for its stimulant, carminative, antiemetic, aphrodisiac, antidiarrheal, analgesic, and hallucinogenic effects. Various studies showed
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Dasgupta, Amitava, and Kimberly Klein. "Oxidative Stress Caused by Cigarette Smoking, Alcohol Abuse, and Drug Abuse." In Antioxidants in Food, Vitamins and Supplements. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-405872-9.00004-5.

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Reis da Silva, Tiago Manuel Horta. "Nutritional Powerhouses." In Drug Discovery and Antiaging Approaches for Human Longevity. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-9730-5.ch011.

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This chapter explores the role of natural compounds in mitigating age-related challenges such as loneliness, elder abuse, dehydration, falls risk, and incontinence. As ageing progresses, physiological and psychological vulnerabilities increase, necessitating targeted nutritional interventions to enhance overall well-being. The chapter examines bioactive compounds, including antioxidants, omega-3 fatty acids, and polyphenols, which support cognitive health, emotional resilience, and physical function. It also discusses hydration strategies, muscle-strengthening nutrients, and bladder-supportive
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Swamy, Jayashri Mahadev, Amogha K.R, Somnath R. Yadav, Junaid Sidiq, and Ganapathi Naik M. "HARNESSING THE POTENTIAL OF HERBAL BIOMEDICINES IN AQUACULTURE." In Futuristic Trends in Aquaculture. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurch193.

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Aquaculture a driving force in enhancing global prosperity and providing cheap source of protein. This has put pressure in the field resulting in use and abuse of antibiotics to counteract diseases caused due to intensification. Growing awareness of the adverse impacts of antibiotics has spurred a widespread shift towards natural products. The potentiality of various extracts from plants and animals as immunomodulators, appetite stimulants, anti-stress agents, antioxidants, antibacterial, antifungal, and antiviral agents is emphasised and proven with better results. These biomedicines also pla
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