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Journal articles on the topic 'Antioxidant defense system'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Chahal, Anterpreet, Adesh K. Saini, Anil Kumar Chhillar, and Reena V. Saini. "NATURAL ANTIOXIDANTS AS DEFENSE SYSTEM AGAINST CANCER." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 38. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24119.

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In living cells, the production of free radicals that comprise both reactive oxygen species (ROS) and reactive nitrogen species is highly regulated that help the cells to sustain redox homeostasis. Overproduction of ROS from mitochondrial electron transport chain leakage or excessive stimulation of xanthine oxidase and other oxidative enzymes leads to the uncontrolled production of free radicals leading to oxidative stress that can mediate damage to cell structures. This damage can be repaired by the antioxidant defense system. Antioxidants are capable of stabilizing, or deactivating, free rad

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Nikitina, O. A., M. A. Darenskaya, N. V. Semenova, and L. I. Kolesnikova. "Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination." Сибирский научный медицинский журнал 42, no. 3 (2022): 4–17. http://dx.doi.org/10.18699/ssmj20220301.

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An increase in peroxidation activity is considered as a nonspecific process characteristic of the pathogenesis of various diseases accompanied by antioxidant deficiency. As bioregulators that can increase defense, antioxidants are important links in a multi-stage system of regulation and coordination of various body functions. The structure and function of enzymes involved in the regulation of oxidative stress can be significantly affected by genetic polymorphism. To date, the role of genes encoding the activity of enzymes of the antioxidant system in the pathogenesis of many diseases remains

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Gao, Yan, Xuan Dong, Rongjin Wang, et al. "Exogenous Calcium Alleviates Oxidative Stress Caused by Salt Stress in Peanut Seedling Roots by Regulating the Antioxidant Enzyme System and Flavonoid Biosynthesis." Antioxidants 13, no. 2 (2024): 233. http://dx.doi.org/10.3390/antiox13020233.

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Soil salinity is one of the adversity stresses plants face, and antioxidant defense mechanisms play an essential role in plant resistance. We investigated the effects of exogenous calcium on the antioxidant defense system in peanut seedling roots that are under salt stress by using indices including the transcriptome and absolute quantitative metabolome of flavonoids. Under salt stress conditions, the antioxidant defense capacity of enzymatic systems was weakened and the antioxidant capacity of the linked AsA-GSH cycle was effectively inhibited. In contrast, the ascorbate biosynthesis pathway

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4

Antonova, Ekaterina Petrovna, Viktor Ilyukha, and Svetlana Sergina. "Antioxidant defense system in hibernating mammals." Principles of the Ecology 14, no. 2 (2015): 4–20. http://dx.doi.org/10.15393/j1.art.2015.3962.

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5

SATO, MASAO. "Biological Antioxidant Defense System and Metallothionein." Eisei kagaku 38, no. 3 (1992): 228–39. http://dx.doi.org/10.1248/jhs1956.38.228.

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Baharuddin, Baharuddin. "Antioxidant Protection Mechanisms in the Cardiovascular System." Asian Journal of Medicine and Health 22, no. 6 (2024): 140–46. http://dx.doi.org/10.9734/ajmah/2024/v22i61029.

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The cardiovascular system, consisting of the heart and blood vessels, plays a critical role in maintaining the consistency of blood flow to supply oxygen throughout the body. Changes in the dynamics of blood flow can occur with the progression of disease exposure. Reactive oxygen species (ROS) are a major trigger for cardiomyocyte and endothelial dysfunction. Therefore, an antioxidant defense system is essential for prevention. This review aims to provide insights into the primary mechanisms of antioxidants in their role as cardioprotective agents. The human body has at least five defense mech

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Dmochowska-Ślęzak, Kamila, Małgorzata Dmitryjuk, Ewa Zaobidna, and Krystyna Żółtowska. "The antioxidant defense system of Varroa destructor mites facilitates the infestation of Apis mellifera." Journal of Apicultural Science 60, no. 1 (2016): 163–66. http://dx.doi.org/10.1515/jas-2016-0010.

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Abstract Varroa destructor is a parasitic mite of the Western honey bee. The activity of five antioxidant enzymes of V. destructor were analysed. Glutathione content and total antioxidant status was also evaluated. Our results suggest that antioxidant enzymes constitute the main line of defense against ROS in V. destructor, whereas low-molecular-weight antioxidants play a limited role in the antioxidant system of mites.

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Virk, Tuba Latif, Qi Liu, Yuguo Yuan, Xianyu Xu, and Fenglei Chen. "Curcumin as Therapeutic Modulator of Impaired Antioxidant Defense System: Implications for Oxidative Stress-Associated Reproductive Dysfunction." Biology 14, no. 7 (2025): 750. https://doi.org/10.3390/biology14070750.

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One of the critical challenges in assisted reproductive technology (ART) is the inadequacy of effective regulation of reactive oxygen species. Simultaneously, the endogenous antioxidant defense system plays a significant role in combating oxidative stress across various physiological stages of embryonic development. However, these intrinsic defense systems alone are insufficient as they rely on exogenous antioxidants that interact synergistically to enhance and sustain antioxidant capacity. Considering the principal role of antioxidants in mitigating oxidative stress in oocyte growth, identify

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Afifi, Mohamed, and Ali Alkaladi. "Antioxidant system in Uromastyx philbyi during hibernation and activity periods." Open Life Sciences 9, no. 9 (2014): 864–68. http://dx.doi.org/10.2478/s11535-014-0318-x.

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AbstractHibernation is an extreme physiological state characterized by profound decreases in oxidative metabolism and body temperature during bouts of prolonged torpor, interrupted by brief periods of arousal with sudden increases in oxidative metabolism, with alterations in antioxidant defenses. We monitored the activities of antioxidant enzymes and oxidative stress during hibernation and activity in Uromastyx philbyi. 20 animals were used, 10 of which were collected in the hibernation season (group I) and the other 10 collected during the active period (group II). Blood, liver, brown adipose

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10

D.R., Aliyeva. "Antioxidants Eliminating Reactive Oxygen Species and Their Classification Forms." Journal of Life Sciences and Biomedicine 71, no. 1 (2016): 20–24. https://doi.org/10.5281/zenodo.7419309.

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Antioxidant Defense System (AOS) realizes the control over damaging effects of reactive oxygen species (ROS) in cells. Due to the powerful antioxidant system, plants can maintain control over the formation and detoxification of ROS under normal conditions. The components of this system are varied and numerous. A lot of materials about antioxidants have been accumulated recently and their classification is required. Unfortunately, there is still no standard classification of antioxidants. Available classification forms of antioxidants have been discussed in this paper

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11

Abazyan, B. N., A. G. Gevorgyan, and V. Rafayelyan. "The antioxidant defense system in late hypokinesia." Experimental Neurology 198, no. 2 (2006): 558. http://dx.doi.org/10.1016/j.expneurol.2006.02.017.

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12

Tajimuratovna, Babajanova Umida. "Associations between oxidative stress and antioxidant protection system in affective-respiratory paroxysm." International Journal of Medical Sciences And Clinical Research 5, no. 2 (2025): 13–15. https://doi.org/10.37547/ijmscr/volume05issue02-03.

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Affective-respiratory paroxysm (ARP) is an episodic loss of consciousness that occurs in children, and its mechanism is not fully understood. The aim of this study was to evaluate the state of oxidative stress and antioxidant defense system in children with ARP. The results show that the ARP group had higher levels of malondialdehyde (MDA) and reactive oxygen species (ROS), while the activity of antioxidant enzymes (SOD and GPx) was decreased. This indicates that the imbalance between oxidative stress and the antioxidant defense system may play an important role in the development of ARP. Ther

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13

Kovalyova, O. M., and T. M. Pasiieshvili. "Biological and medical value of antioxidant protection system of the human body." Medicine Today and Tomorrow 90, no. 1 (2021): 21–32. http://dx.doi.org/10.35339/msz.2021.90.01.03.

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The article is devoted to the antioxidant system of the human body in the context of biological and medical significance. The classification of antioxidants in terms of their physical and chemical properties, bioorganic compounds, biochemical effects, mechanisms of implementation of antioxidant protection is presented. The given processes of extreme radical oxidation and mechanisms of antioxidant defense in physiological and pathological conditions. The characteristics of the components of the glutathione system, namely glutathione and enzymes – glutathione peroxidase, glutathione reductase an

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Altaf, Sidra, Rao Zahid Abbas, Tayyaba Akhtar, et al. "Antioxidant rich medicinal plants as a potential candidate to treat gastric ulcer." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 5 (2023): 560–80. http://dx.doi.org/10.37360/blacpma.23.22.5.41.

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Oxidative stress is a key cause of gastrointestinal disorders, primarily stomach ulcers. Multiple intrinsic and extrinsic mechanisms caused the body to produce reactive oxygen species (ROS). The body's antioxidant defense system protects against these reactive species. When the degree of ROS production exceeds the normal range, the body's natural defense system fails to neutralize these dangerous free radicals, necessitating need foran exogenous source of natural antioxidants. Natural herbal remedies have been widely employed as antioxidants to relieve oxidative stress in gastric ulcers. Polyp

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15

Vidović, Bojana. "Dietary antioxidants and health effects: What are their optimal intakes?" Arhiv za farmaciju 73, no. 4 (2023): 278–91. http://dx.doi.org/10.5937/arhfarm73-45552.

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A well-balanced diet provides many compounds with antioxidant properties, such as vitamins, minerals, provitamins (e.g., b-carotene), and phytochemicals (e.g., carotenoids, polyphenols, organosulfur compounds). In addition to direct antioxidants, foods indirectly support the endogenous defense system, by providing substrates for the synthesis of glutathione, antioxidant defense enzymes, metal-binding proteins, or modulators of redox-dependent signaling pathways. Epidemiological studies indicate that higher intakes and circulating concentrations of vitamins C, E, carotenoids, and flavonoids ref

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Isamukhamedova, Dildora Rakhmatillaevna. "THE EFFECT OF BIOLOGICALLY ACTIVE SUBSTANCES ON THE BODY'S ANTIOXIDANT SYSTEM DURING OXIDATIVE STRESS." American Journal of Advanced Scientific Research (AJASR) 2, no. 9 (2025): 149–53. https://doi.org/10.5281/zenodo.15235125.

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Oxidative stress plays a critical role in the pathogenesis of various chronicdiseases and aging processes. The body’s antioxidant defense system is responsiblefor maintaining redox balance and protecting cellular components from oxidativedamage. This study investigates the impact of biologically active substances (BAS),including vitamins, polyphenols, and other antioxidants, on the functionality andefficiency of the endogenous antioxidant system during oxidative stress. Utilizingboth in vivo and in vitro models, the study evaluates how BAS modulates oxidativemarkers and improves antioxid

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17

Wang, Haozheng, Xiaodong Xu, Runhai Chen, et al. "Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers." ACS Applied Materials & Interfaces 9, no. 44 (2017): 38313–22. http://dx.doi.org/10.1021/acsami.7b12395.

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18

Chen, K. M., H. J. Gong, S. M. Wang, and C. L. Zhang. "Antioxidant defense system in Phragmites communis Trin. ecotypes." Biologia plantarum 51, no. 4 (2007): 754–58. http://dx.doi.org/10.1007/s10535-007-0154-1.

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19

Il’ina, T. N., V. A. Ilyukha, I. V. Baishnikova, V. V. Belkin, S. N. Sergina, and E. P. Antonova. "Antioxidant defense system in tissues of semiaquatic mammals." Journal of Evolutionary Biochemistry and Physiology 53, no. 4 (2017): 282–88. http://dx.doi.org/10.1134/s0022093017040044.

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20

Bora, Kushal, Shankar Prasad Kanaujia, and Vikash Kumar Dubey. "Targeting antioxidant defense system enzymes for Leishmaniasis treatment." International Journal of Biological Macromolecules 316 (June 2025): 144650. https://doi.org/10.1016/j.ijbiomac.2025.144650.

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21

Lavryshyn, Y. Y., I. S. Varkholyak, T. V. Martyschuk, Z. А. Guta та L. B. Ivankiv. "БІОЛОГІЧНЕ ЗНАЧЕННЯ СИСТЕМИ АНТИОКСИДАНТНОГО ЗАХИСТУ ОРГАНІЗМУ ТВАРИН". Scientific Messenger of LNU of Veterinary Medicine and Biotechnology 18, № 2(66) (2016): 100–112. http://dx.doi.org/10.15421/nvlvet6622.

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In the review of the literature it was generalized the data due to the classification and characterization of antioxidant protection system of animals body. This model combines a number of different by its nature substances. Each of the components of the antioxidant system operates in close relationship with its other structural elements, harmoniously, and in many cases complements and in many cases - enhances the action of each other. Glutathione system forms functional basis of antioxidant defense system, constituent elements of which has its own glutathione and enzymes, which catalyze the r

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22

Ilderbayev, Oralbek Z., Sergey V. Kashanskiy, Laura Ye Chulenbayeva, Masygut R. Mynzhanov, and Gulzhan O. Ilderbayeva. "Disorders of immune state parameters and lipid peroxidation under experimental exposure to radiation." Occupational Health and Industrial Ecology, no. 11 (February 18, 2019): 16–21. http://dx.doi.org/10.31089/1026-9428-2018-11-16-21.

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The article presents experimental data on the impact of high dose gamma-radiation exposure (6 Gy) on immune system, lipid oxidation products (LOPs) and antioxidant defense system (AODS) enzymes activity. The study revealed that high dose radiation exposure suppressed the cell-mediated immunity especially with respect to T-lymphocytes and their subpopulations as well as immune defense and adaptation mechanisms. Ionizing radiation exposure led to increase of conjugated lipid dienes and malondialdehyde (MDA), and to inhibition of catalase and glutathione peroxidise activity, thus promoting oxidat

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23

Gutyj, B. V., S. D. Mursjka, D. F. Hufrij, et al. "Influence of cadmium loading on the state of the antioxidant system in the organism of bulls." Biosystems Diversity 24, no. 1 (2016): 96–102. http://dx.doi.org/10.15421/011611.

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This article presents the results of research on the influence of cadmium loading on the state level of enzymatic and non-enzymatic antioxidant links of the antioxidant defense system of the organisms of young cattle, such as the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels, selenium, vitamins A and E. It was found that feeding bull calves with cadmium chloride at doses of 0.03 and 0.05 mg/kg of body weight helped to reduce both the enzymatic and non-enzymatic link of antioxidant protection (superoxide dismutase 31%, catalase 13%, glutathione peroxidas

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Mochida, Naoko, Yoko Matsumura, Masahiro Kitabatake, Toshihiro Ito, Shin-ichi Kayano, and Hiroe Kikuzaki. "Antioxidant Potential of Non-Extractable Fractions of Dried Persimmon (Diospyros kaki Thunb.) in Streptozotocin-Induced Diabetic Rats." Antioxidants 11, no. 8 (2022): 1555. http://dx.doi.org/10.3390/antiox11081555.

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Oxidative stress causes the progression of diabetes and its complications; thus, maintaining the balance between reactive oxygen species produced by hyperglycemia and the antioxidant defense system is important. We herein examined the antioxidant potential of non-extractable fractions of dried persimmon (NEP) against oxidative stress in diabetic rats. Rats with streptozotocin-induced type 1 diabetes (50 mg/kg body weight) were administered NEP for 9 weeks. Antioxidant enzyme activities and concentration of antioxidants in liver tissues were analyzed with a microplate reader. Extensor digitorum

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Kachungwa Lugata, James, Arth David Sol Valmoria Ortega, and Csaba Szabó. "The Role of Methionine Supplementation on Oxidative Stress and Antioxidant Status of Poultry-A Review." Agriculture 12, no. 10 (2022): 1701. http://dx.doi.org/10.3390/agriculture12101701.

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The physiological status of poultry can be disturbed by different stressors that may lead to oxidative stress conditions. Oxidative stress activates defense systems, which mitigates the adverse effects. Several lines of the poultry defense system exist, including enzyme systems such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and non-enzymatic antioxidants such as Glutathione (GSH). Methionine—a vital amino acid in poultry nutrition—plays a significant role in protein synthesis, transsulfuration, and transmethylation and is also involved in several biochemical

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Raza, Muhammad Asim, Malka Samra Malik, Muhammad Azam, and Muhammad Azam. "Impact of Natural Antioxidants on Biological Systems." Lahore Garrison University Journal of Life Sciences 4, no. 02 (2020): 139–62. http://dx.doi.org/10.54692/lgujls.2019.0402105.

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ABSTRACT:Free radicals are the unstable electron-deficient species that reacts with different molecules to gain stability and to eliminate their unpaired condition. Antioxidant molecules neutralizes the free radicals by donating their electrons and inhibits the unwanted oxidative reactions in biological system. The imbalance between antioxidants and free radicals generated oxidative stress which leads to severe impairment of the biological systems. The purpose of the present review is to highlight the beneficial role of naturally occurring antioxidant systems in minimizing the damage and maint

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D.R.Aliyeva. "The Role Of Nonenzymatic Antioxidant Substances In The Plant Defense Against Stress." Journal of Life Sciences and Biomedicine 2017, no. 2 (2023): 21–31. https://doi.org/10.5281/zenodo.7908976.

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Plants are quite tolerant to the effects of oxidative stress formed due to adverse environmental conditions. It is attributed to strong defense mechanisms of plant cells. The complex multi-component antioxidant defense system (AOS) consists of low-molecular weight nonenzymatic antioxidant substances and high-molecular weight nonenzymatic enzymes. Nonenzymatic system is more complex and multifaceted. These substances express direct or indirect antioxidant effects as membrane-protectors, chaperones, signal-regulating compounds.

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Gutyj, B. V., D. F. Gufriy, V. Y. Binkevych, et al. "Influence of cadmium loading on glutathione system of antioxidant protection of the bullocks’bodies." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 92 (2018): 34–40. http://dx.doi.org/10.32718/nvlvet9207.

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It was presented the results of studies of the cadmium effect loading on the activity of the glutathione system of antioxidant protection in young cattle, namely on the activity of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, the level of reduced glutathion. It was established that feeding of cadmium chloride to bullocks at a dose of 0.03 and 0.05 mg/kg body weight contributed to a decrease in both the enzyme and non-enzyme link of the glutathione antioxidant defense system. The toxic effect of cadmium contributes to a change in stationary concentrations of

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29

Howden, Reuben. "Nrf2and Cardiovascular Defense." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/104308.

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The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction. The pleiotropic transcription factor, nuclear factor-erythroid (NF-E) 2-related factor 2 (Nrf2), regulates the expression of antioxidant enzymes and proteins through the antioxidant response element.Nrf2is an important component in antioxidant defenses in cardiovascular disea

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Kovalyova, O.M., N.D. Chukhrienko, T.M. Pasiieshvili, L.M. Pasiyeshvili, and N.M. Zhelezniakova. "The state of antioxidant defense system in young persons with gastroesophageal reflux disease and autoimmune thyroiditis." Medicni perspektivi 25, no. 4 (2020): 87–93. https://doi.org/10.26641/2307-0404.2020.4.221237.

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Aim of research was assessment of the levels of antioxidant biomarkers associated with mitochondrial function in young patients with gastroesophageal reflux disease (GERD) and autoimmune thyroiditis (AIT). This study included 165 patients of them 120 patients with GERD and AIT - the main group, 45 patients with isolated GERD - the comparison group. The examined contingent was presented by students aged 18 to 25 years. The control group consisted of 20 healthy individuals of corresponding gender, age and social status (students). Total antioxidant activity (TAS-TAC) was determined in blood seru

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Strilbytska, O., A. Zayachkivska, T. Strutynska, U. Semaniuk, A. Vaiserman, and O. Lushchak. "Dietary protein defines stress resistance, oxidative damages and antioxidant defense system in Drosophila melanogaster." Ukrainian Biochemical Journal 93, no. 5 (2021): 90–101. http://dx.doi.org/10.15407/ubj93.05.090.

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Ivanova, K. A., and V. E. Tsyganov. "ANTIOXIDANT DEFENSE SYSTEM IN SYMBIOTIC NODULES OF LEGUMES (review)." Sel'skokhozyaistvennaya Biologiya 52, no. 5 (2017): 878–94. http://dx.doi.org/10.15389/agrobiology.2017.5.878eng.

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Hillas, Patrick J., Federico Soto del Alba, Julen Oyarzabal, Angela Wilks, and Paul R. Ortiz de Montellano. "The AhpC and AhpD Antioxidant Defense System ofMycobacterium tuberculosis." Journal of Biological Chemistry 275, no. 25 (2000): 18801–9. http://dx.doi.org/10.1074/jbc.m001001200.

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AMA, Hassan, and EM Mostafa. "Selenium invoked antioxidant defense system in Azolla caroliniana plant." Phyton 85, no. 1 (2016): 262–69. http://dx.doi.org/10.32604/phyton.2016.85.262.

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Virit, Osman, Abdurrahman Altindag, Mehmet Yumru, et al. "A Defect in the Antioxidant Defense System in Schizophrenia." Neuropsychobiology 60, no. 2 (2009): 87–93. http://dx.doi.org/10.1159/000239684.

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Yao, Jeffrey K., Daniel P. van Kammen, and Ravinder D. Reddy. "Neuroleptic effects on antioxidant defense system enzymes in schizophrenia." Schizophrenia Research 24, no. 1-2 (1997): 70–71. http://dx.doi.org/10.1016/s0920-9964(97)82196-2.

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Mukherjee, S., S. P. Mahadik, E. E. Correnti, and R. Scheffer. "The antioxidant defense system at the onset of psychosis." Biological Psychiatry 35, no. 9 (1994): 701. http://dx.doi.org/10.1016/0006-3223(94)90967-9.

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Asatiani, Nino, Tamar Kartvelishvili, Marina Abuladze, Lali Asanishvili, and Nelly Sapojnikova. "Chromium (VI) Can Activate and Impair Antioxidant Defense System." Biological Trace Element Research 142, no. 3 (2010): 388–97. http://dx.doi.org/10.1007/s12011-010-8806-y.

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Yıldırım, Ö. "Antioxidant Defense System in Cobalt Treated Diabetic Rat Lung." Biotechnology & Biotechnological Equipment 16, no. 1 (2002): 124–30. http://dx.doi.org/10.1080/13102818.2002.10819166.

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Astiz, Mariana, María J. T. de Alaniz, and Carlos Alberto Marra. "Antioxidant defense system in rats simultaneously intoxicated with agrochemicals." Environmental Toxicology and Pharmacology 28, no. 3 (2009): 465–73. http://dx.doi.org/10.1016/j.etap.2009.07.009.

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Kishi, Takeo, Takayuki Takahashi, Akinori Usui, and Tadashi Okamoto. "Ubiquinone redox cycle as a cellular antioxidant defense system." BioFactors 10, no. 2-3 (1999): 131–38. http://dx.doi.org/10.1002/biof.5520100208.

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Álvarez-Barrios, Ana, Lydia Álvarez, Montserrat García, Enol Artime, Rosario Pereiro, and Héctor González-Iglesias. "Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins." Antioxidants 10, no. 1 (2021): 89. http://dx.doi.org/10.3390/antiox10010089.

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The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, includi

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Álvarez-Barrios, Ana, Lydia Álvarez, Montserrat García, Enol Artime, Rosario Pereiro, and Héctor González-Iglesias. "Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins." Antioxidants 10, no. 1 (2021): 89. http://dx.doi.org/10.3390/antiox10010089.

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The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, includi

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Guliyev, M. R., R. R. Goyushova, and R. O. Baylarov. "SOME INDICATORS OF ANTIOXIDANT DEFENSE SYSTEM IN CHRONIC KIDNEY DISEASE." Biological Markers in Fundamental and Clinical Medicine (collection of abstracts) 3, no. 1 (2019): 17. http://dx.doi.org/10.29256/v.03.01.2019.escbm07.

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Rao, Muhammad Junaid, Mingzheng Duan, Caixia Zhou, et al. "Antioxidant Defense System in Plants: Reactive Oxygen Species Production, Signaling, and Scavenging During Abiotic Stress-Induced Oxidative Damage." Horticulturae 11, no. 5 (2025): 477. https://doi.org/10.3390/horticulturae11050477.

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Plants face various abiotic stresses in their natural environments that trigger the production of reactive oxygen species (ROS), leading to oxidative stress and potential cellular damage. This comprehensive review examines the interplay between plant antioxidant defense systems and ROS under abiotic stress conditions. We discuss the major enzymatic antioxidants, including superoxide dismutase, catalase, reductases, and peroxidases, as well as non-enzymatic antioxidants, such as ascorbic acid, glutathione, polyphenols, and flavonoids, which play crucial roles in ROS detoxification. This review

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Khan, Adil, Muhammad Numan, Abdul Latif Khan, et al. "Melatonin: Awakening the Defense Mechanisms during Plant Oxidative Stress." Plants 9, no. 4 (2020): 407. http://dx.doi.org/10.3390/plants9040407.

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Melatonin is a multifunctional signaling molecule that is ubiquitously distributed in different parts of a plant and responsible for stimulating several physio-chemical responses to adverse environmental conditions. In this review, we show that, although plants are able to biosynthesize melatonin, the exogenous application of melatonin to various crops can improve plant growth and development in response to various abiotic and biotic stresses (e.g., drought, unfavorable temperatures, high salinity, heavy metal contamination, acid rain, and combined stresses) by regulating antioxidant machinery

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Hasanuzzaman, Mirza, Md Rakib Hossain Raihan, Abdul Awal Chowdhury Masud, et al. "Regulation of Reactive Oxygen Species and Antioxidant Defense in Plants under Salinity." International Journal of Molecular Sciences 22, no. 17 (2021): 9326. http://dx.doi.org/10.3390/ijms22179326.

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The generation of oxygen radicals and their derivatives, known as reactive oxygen species, (ROS) is a part of the signaling process in higher plants at lower concentrations, but at higher concentrations, those ROS cause oxidative stress. Salinity-induced osmotic stress and ionic stress trigger the overproduction of ROS and, ultimately, result in oxidative damage to cell organelles and membrane components, and at severe levels, they cause cell and plant death. The antioxidant defense system protects the plant from salt-induced oxidative damage by detoxifying the ROS and also by maintaining the

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A Zaki, Noor, and Ayoob O Alfalahi. "Methyl Jasmonate Improves Superoxide Dismutase Activity in Infected Sunflower Plants." E3S Web of Conferences 434 (2023): 03007. http://dx.doi.org/10.1051/e3sconf/202343403007.

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Methyl jasmonate (Meja) is a volatile phythormone that contributes many plant critical processes, especially under biotic and abiotic stresses. Thus, Meja found to effectively regulating the biosynthesis of other plant hormones and/or enzymes, like Superoxide Dismutase (SOD). However, Meja specifically affects the plant antioxidant defense system, particularly SOD activity are still an area of ongoing research. The current results pointed to a clear effect of the applied Meja concentration in shaping the entire response to the biotic oxidative stress resulted from the three pathogenic fungi Fu

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Zaki, Noor A., and Ayoob O. Alfalahi. "Methyl Jasmonate Modulates Peroxidase Activity in Sunflower Varieties Affected by Pathogenic Fungi." IOP Conference Series: Earth and Environmental Science 1262, no. 3 (2023): 032004. http://dx.doi.org/10.1088/1755-1315/1262/3/032004.

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Abstract Methyl jasmonate (Meja) is a volatile phythormone that contributes many plant critical processes, especially under biotic and abiotic stresses. Thus, Meja found to effectively regulating the biosynthesis of other plant hormones and/or enzymes, like preoxidase (POD). However, Meja specifically affects the plant antioxidant defense system, particularly POD activity are still an area of ongoing research. The current results pointed to a clear effect of the applied Meja concentration in shaping the entire response to the biotic oxidative stress resulted from the three pathogenic fungi Fus

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Murphy, Kelsey, Killian Llewellyn, Samuel Wakser, et al. "Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system." Journal of Biological Chemistry 293, no. 47 (2018): 18242–69. http://dx.doi.org/10.1074/jbc.ra117.001245.

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Oxidative stress triggers and exacerbates neurodegeneration in Alzheimer's disease (AD). Various antioxidants reduce oxidative stress, but these agents have little efficacy due to poor blood–brain barrier (BBB) permeability. Additionally, single-modal antioxidants are easily overwhelmed by global oxidative stress. Activating nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) and its downstream antioxidant system are considered very effective for reducing global oxidative stress. Thus far, only a few BBB-permeable agents activate the Nrf2-dependent antioxidant system. Here, we discovere

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