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Relevant bibliographies by topics / Antitrypanosomal

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Academic literature on the topic 'Antitrypanosomal'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Antitrypanosomal"

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Dofuor, Aboagye Kwarteng, Temitayo Samson Ademolue, Cynthia Mmalebna Amisigo, Kwaku Kyeremeh, and Theresa Manful Gwira. "Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis." Molecules 26, no. 15 (2021): 4488. http://dx.doi.org/10.3390/molecules26154488.

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The search for novel antitrypanosomals and the investigation into their mode of action remain crucial due to the toxicity and resistance of commercially available antitrypanosomal drugs. In this study, two novel antitrypanosomals, tortodofuordioxamide (compound 2) and tortodofuorpyramide (compound 3), were chemically derived from the natural N-alkylamide tortozanthoxylamide (compound 1) through structural modification. The chemical structures of these compounds were confirmed through spectrometric and spectroscopic analysis, and their in vitro efficacy and possible mechanisms of action were, s

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O Igoli, John, Poorna Kantheti, and Rajeev K Singla. "Antitrypanosomal Activity of Extract Fractions of Cetraria Islandica." Indo Global Journal of Pharmaceutical Sciences 02, no. 04 (2012): 348–50. http://dx.doi.org/10.35652/igjps.2012.40.

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The antitrypanosomal activity of various extract fractions of C. islandica (Iceland moss) was evaluated by using the well-established Alamar blue™ 96 well microplate assay. The antitrypanosomal activity significantly increased with increasing amounts of fractions (from 10-20 µg/ml) and MIC of 12.5µg/ml were observed for certain fractions. The results obtained in the present study indicate that C. islandica is a potential source of natural antitrypanosomal agents. © 2011 IGJPS. All rights reserved.

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Steverding, Dietmar, and Kevin M. Tyler. "Novel antitrypanosomal agents." Expert Opinion on Investigational Drugs 14, no. 8 (2005): 939–55. http://dx.doi.org/10.1517/13543784.14.8.939.

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Sealey-Cardona, Marco, Simon Cammerer, Simon Jones, et al. "Kinetic Characterization of Squalene Synthase from Trypanosoma cruzi: Selective Inhibition by Quinuclidine Derivatives." Antimicrobial Agents and Chemotherapy 51, no. 6 (2007): 2123–29. http://dx.doi.org/10.1128/aac.01454-06.

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ABSTRACT The biosynthesis of sterols is a major route for the development of antitrypanosomals. Squalene synthase (SQS) catalyzes the first step committed to the biosynthesis of sterols within the isoprenoid pathway, and several inhibitors of the enzyme have selective antitrypanosomal activity both in vivo and in vitro. The enzyme from Trypanosoma cruzi is a 404-amino-acid protein with a clearly identifiable membrane-spanning region. In an effort to generate soluble recombinant enzyme, we have expressed in Escherichia coli several truncated versions of T. cruzi SQS with a His tag attached to t

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Kaminsky, R., E. Zweygarth, and E. De Clercq. "Antitrypanosomal Activity of Phosphonylmethoxyalkylpurines." Journal of Parasitology 80, no. 6 (1994): 1026. http://dx.doi.org/10.2307/3283453.

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Nenortas, Elizabeth, Christian Burri, and Theresa A. Shapiro. "Antitrypanosomal Activity of Fluoroquinolones." Antimicrobial Agents and Chemotherapy 43, no. 8 (1999): 2066–68. http://dx.doi.org/10.1128/aac.43.8.2066.

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ABSTRACT Six fluoroquinolones presently in clinical use and four investigational tetracyclic fluoroquinolones were tested for in vitro activity against bloodstream-form Trypanosoma brucei brucei. All compounds had measurable activity, but the tetracyclic analogs were most potent, with 50% effective concentrations in the low micromolar range. In general, trypanosomes were more susceptible than L1210 leukemia cells. Consistent with the notion that they target type II topoisomerase in trypanosomes, the fluoroquinolones promote the formation of protein-DNA covalent complexes.

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Scovill, John, Elizabeth Blank, Michael Konnick, Elizabeth Nenortas, and Theresa Shapiro. "Antitrypanosomal Activities of Tryptanthrins." Antimicrobial Agents and Chemotherapy 46, no. 3 (2002): 882–83. http://dx.doi.org/10.1128/aac.46.3.882-883.2002.

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ABSTRACT New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM.

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Abdeta, Debela, Nigatu Kebede, Mirutse Giday, Getachew Terefe, and Solomon Mequanente Abay. "In Vitro and In Vivo Antitrypanosomal Activities of Methanol Extract of Echinops kebericho Roots." Evidence-Based Complementary and Alternative Medicine 2020 (September 22, 2020): 1–6. http://dx.doi.org/10.1155/2020/8146756.

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Microbial resistance to the few conventional antitrypanosomal drugs, increasing resistance of vectors to insecticides, lack of effective vaccines, and adverse effects of the existing antitrypanosomal drugs justify the urgent need for effective, tolerable, and affordable drugs. We assessed antitrypanosomal effects of the hydromethanolic extract of Echinops kebericho Mesfin roots against Trypanosoma congolense field isolate using in vitro and in vivo techniques. Parasite load, packed cell volume (PCV), body weight, and rectal temperature in Swiss albino mice were assessed. This finding is part o

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Jesumoroti, Omobolanle J., Richard M. Beteck, and Lesetja J. Legoabe. "In-vitro Anti-trypanosomal and Cytotoxicity Evaluation of 3-methyl-3,4-dihydroquinazolin-2(1H)-one Derivatives." Drug Research 71, no. 06 (2021): 335–40. http://dx.doi.org/10.1055/a-1349-1256.

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Sleeping sickness, caused by trypanosomes, is a debilitating, neglected tropical disease wherein current treatments suffer from several drawbacks such as toxicity, low activity, and poor pharmacokinetic properties, and hence the need for alternative treatment is apparent. To this effect, we screened in vitro a library of 2-quinazolinone derivatives for antitrypanosomal activity against T.b. brucei and cytotoxicity against HeLa cells. Seven compounds having no overt cytotoxicity against HeLa cells exhibited antitrypanosomal activity in the range of 0.093–45 µM were identified. The activity data

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Nyunt, Khine Swe, Ahmed Elkhateeb, Yusuke Tosa, Kensuke Nabata, Ken Katakura, and Hideyuki Matsuura. "Isolation of Antitrypanosomal Compounds from Vitis repens, a Medicinal Plant of Myanmar." Natural Product Communications 7, no. 5 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700516.

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Bioactivity-guided fractionation of an ethanolic extract of Vitis repens led to the isolation of resveratrol (1), 11- O-acetyl bergenin (2), and stigmast-4-en-3-one (3). The compounds were examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Resveratrol showed antitrypanosomal activity with an IC50 value of 0.13 μM, whereas 11- O-acetyl bergenin and stigmast-4-en-3-one exhibited IC50 values of 0.17 and 0.15 μM, respectively.

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Dissertations / Theses on the topic "Antitrypanosomal"

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Clark, Rachel L. "The development of new broad spectrum antitrypanosomal agents." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415310.

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Golisade, Abolfasl. "Polymerunterstützte Synthese von antitrypanosomal und anti-Malaria-aktiven Adenosinderivaten." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964083248.

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Mungongo, Singfrid Gasper. "The design, synthesis and biological evaluation of novel antitrypanosomal drugs." Thesis, University of Sunderland, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284073.

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Skaf, Joseph [Verfasser], and Ulrike [Gutachter] Holzgrabe. "Antileishmanial and antitrypanosomal compounds from \(Achillea\) \(fragrantissima\) / Joseph Skaf ; Gutachter: Ulrike Holzgrabe." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1166560244/34.

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Zulu, Ayanda Ignatia. "Synthesis and evaluation of arylpyrrole-chalcone hybrids as antiplasmodial and antitrypanosomal agents." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/65268.

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Rathnam, Rajendra Prasad. "Synthesis and biological evaluation of 1,4-benzodiazepin-2-one analogues with antitrypanosomal activity." Thesis, University of Greenwich, 2010. http://gala.gre.ac.uk/8110/.

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The 1,4-benzodiazepin-2-one motif has been taken as a privileged skeleton for making antitrypanosomal agents. A library of over sixty 1,4-benzodiazepin-2-one derivatives has been synthesised employing novel synthetic routes. These derivatives were characterised spectroscopically, by mass spectrometry, and by combustion analysis. Five derivatives were characterised, in the solid state, by single crystal X-ray crystallography. Biological assays of the library of compounds against Trypanosoma brucei brucei (T. b brucei) revealed a range of trypanocidal activities. A first generation library activ

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He, Shanshan. "Neglected Tropical Disease Chemotherapy: Mechanistic Characterization of Antitrypanosomal Dihydroquinolines and Development of a High Throughput Antileishmanial Screening Assay." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337980540.

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Maiwald, Franziska [Verfasser], and Conrad [Akademischer Betreuer] Kunick. "Synthese neuer 4-Azapaullone als potenziell antitrypanosomale Wirkstoffe / Franziska Maiwald ; Betreuer: Conrad Kunick." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175821853/34.

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Murebwayire, Sengabo. "Etudes des propriétés antiplasmodiales, antitrypanosomales et inhibitrices d'acétylcholinestérase de triclisia sacleuxii (Pierre) Diels "Menispermaceae"." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210506.

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Le paludisme, la maladie la plus dévastatrice des régions tropicales fait l’objet de nombreuses recherches ayant pour but de trouver des médicaments préventifs, du matériel de protection, de nouveaux traitements, des vaccins, …<p>Notre travail s’est inscrit dans la recherche des composés naturels actifs sur l’agent pathogène, le Plasmodium. Nos investigations phytochimiques et pharmacologiques ont porté sur Triclisia sacleuxii, une plante utilisée en médecine traditionnelle pour traiter diverses maladies dont deux parasitaires: la schistosomiase et l’ascardiose. Elle est aussi employée dans la

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Wendling, Ana Paula Barbosa. "Desempenho da pesquisa de anticorpos antiTrypanosoma cruzi, por citometria de fluxo, na monitoração precoce de cura pósterapêutica etiológica da doença de Chagas." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/ECJS-7GJN9A.

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Specific therapy of chronic Chagas disease aims mainly to reduce parasitemia, besides preventing and reducing symptoms. However, monitoring treatment efficacy still remains unclear due to the lack of laboratorial methods that could certify a complete parasitological cure. Currently, the cure criteria used by various researchers is based on repeated serological and parasitological negative tests. Several studies have shown that serology can remain positive for decades after specific therapeutics. The introduction of highly sensitive techniques such as specific antibodies detection by flow citom

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Book chapters on the topic "Antitrypanosomal"

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Alberti, Andrés Sánchez, Natacha Cerny, Augusto Bivona, and Silvia I. Cazorla. "Antitrypanosomal and Antileishmanial Activities." In Sesquiterpene Lactones. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78274-4_8.

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Nardella, Flore, Jean-Baptiste Gallé, Mélanie Bourjot, Bernard Weniger, and Catherine Vonthron-Sénécheau. "Antileishmanial and Antitrypanosomal Activities of Flavonoids." In Sustainable Development and Biodiversity. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67045-4_7.

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Valente, María, Antonio E. Vidal, and Dolores González Pacanowska. "Potential of Pyrimidine Metabolism for Antitrypanosomal Drug Discovery." In Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527694082.ch6.

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"Antitrypanosomal and Antileishmanial Targets." In Chemotherapeutic Targets in Parasites. Cambridge University Press, 2002. http://dx.doi.org/10.1017/cbo9780511546440.006.

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Meneguetti, Dionatas Ulises de Oliveira, Adila Costa de Jesus, Fernanda Portela Madeira, and Romeu Paulo Martins Silva. "ANTITRYPANOSOMAL ETHNOPHARMACOLOGY IN THE BRAZILIAN AMAZON." In Patologias: Doenças Parasitárias. Antonella Carvalho de Oliveira, 2019. http://dx.doi.org/10.22533/at.ed.9781918037.

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Kryshchyshyn, Anna, Danylo Kaminskyy, Philippe Grellier, and Roman Lesyk. "Thiazolidinone-Related Heterocyclic Compounds as Potential Antitrypanosomal Agents." In Azoles - Synthesis, Properties, Applications and Perspectives [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.91861.

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Man, Anthony, and Florencia Segal. "New Therapeutics for Chagas Disease: Charting a Course to Drug Approval." In Chagas Disease - From Cellular and Molecular Aspects of Trypanosoma cruzi-Host Interactions to the Clinical Intervention. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102891.

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Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinical drug development of a novel antitrypanosomal agent for Chagas disease. The various elements that contribute to a robust assessment of treatment effect including dose selection, choice of patient population, trial methodology, endpoint measures, and regulatory perspectives are discussed. The learni

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Taber, Douglass. "Complex Cyclic Ethers: (+)-Conocarpan (Hashimoto), (-)-Brevisamide (Satake/ Tachibana), (+)-Bruguierol A (Fañanás/ Rodríguez), (-)-Berkelic Acid (Snider), and (-)-Aigialomycin D (Harvey)." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0052.

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( + )-Conocarpan 3, isolated from the wood of Conocarpus erectus , exhibits insecticidal, antifungal and antitrypanosomal activity. Shunichi Hashimoto of Hokkaido University developed (J. Org. Chem. 2009, 74 , 4418) a chiral Rh (II) carboxylate that effected the cyclization of 1 to 2, setting the absolute configuration of 3. The dinoflagellate Karenia brevis produces the brevetoxins, a family of complex polyethers. Recently, the first N-containing cyclic ether, (-)-Brevisamide 6, was isolated from K. brevis . Masayuki Satake and Kazuo Tachibana of the University of Tokyo, in their synthesis of

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Conference papers on the topic "Antitrypanosomal"

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Háznagy, M., M. Vágvölgyi, S. R. Krishnan, J. Gertsch, and A. Hunyadi. "Antitrypanosomal activity of semisyntetic enone-type derivatives." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759246.

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B. Háznagy, Márton, Máté Vágvölgyi, Sandhya R. Krishnan, Jürg Gertsch, and Attila Hunyadi. "Antitrypanosomal activity of natural and semi-synthetic ecdysteroids." In 4th International Symposium of Young Researchers on Medicinal Plants and Natural Product Research. Institute of Pharmacognosy, University of Szeged, Faculty of Pharmacy, 2023. http://dx.doi.org/10.14232/syrmpnpr.2023.10.

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VazquezRodriguez, Saleta, Maria João Matos, Roberto Figueroa Guíñez, et al. "Coumarin-chalcone Derivatives as Potential Antitrypanosomal and Antioxidant Compounds." In The 16th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2012. http://dx.doi.org/10.3390/ecsoc-16-01037.

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Adefolaju, Oluwaferanmi, and Abdulkadir Abubakar. "ANTITRYPANOSOMAL POTENTIAL OF BUCHHOLZIA CORIACEA SEED EXTRACTS IN MICE." In MOL2NET 2019, International Conference on Multidisciplinary Sciences, 5th edition. MDPI, 2019. http://dx.doi.org/10.3390/mol2net-05-06242.

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Kimani, Njogu, Josphat Matasyoh, Marcel Kaiser, Mauro Nogueira, Gustavo Trossini, and Thomas Schmidt. "An extended study on quantitative structure-antitrypanosomal activity relationships of sesquiterpene lactones." In 4th International Electronic Conference on Medicinal Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05591.

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Suckling, Colin J., Fraser Scott, Abedawn Khalaf, et al. "Minor Groove Binders for DNA as Antitrypanosomal Agents: the Veterinary Context." In 3rd International Electronic Conference on Medicinal Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04647.

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Soares, Ozildéia, Gabriela R. Hurtado, Luiz H. Viana, Sérgio de Albuquerque, and Adriano C. M. Baroni. "Synthesis of Isoxazolic analogues derivatives of Grandisin and Veraguensin neolignans with anti-leishmania and antitrypanosomal activities." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20139410384.

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Montero-Torres, Alina, María Vega, Yovani Marrero-Ponce, et al. "A Novel Non-Stochastic Quadratic Fingerprints-Based Approach for the “in silico” Discovery of New Antitrypanosomal Compounds." In The 9th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01663.

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Lago, J., S. Grecco, T. Costa-Silva, et al. "Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608157.

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Kimani, M., J. Matasyoh, M. Kaiser, R. Brun, and TJ Schmidt. "Antitrypanosomale Sesquiterpenlactone aus Vernonia cinerascens." In Phytotherapie 2017 „Von der Innovation zur Evidenz“. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1607128.

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Reports on the topic "Antitrypanosomal"

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Markovac, A., D. J. Dagli, R. L. Kalamas, G. S. Wu, A. B. Ash, and C. L. Stevens. Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs Treatment and Prophylaxis. Defense Technical Information Center, 1986. http://dx.doi.org/10.21236/adb110976.

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Markovac, A., D. J. Dagli, A. B. Ash, and C. L. Stevens. Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs, Treatment and Prophylaxis. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/adb121621.

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Markovac, A., D. J. Dagli, A. B. Ash, and C. L. Stevens. Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs, Treatment and Prophylaxis. Defense Technical Information Center, 1989. http://dx.doi.org/10.21236/adb145101.

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