Relevant bibliographies by topics / Antiviral agents Ribosomes

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Academic literature on the topic 'Antiviral agents Ribosomes'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Antiviral agents Ribosomes"

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Brunelle, Marie-Noëlle, Léa Brakier-Gingras, and Guy Lemay. "Replacement of Murine Leukemia Virus Readthrough Mechanism by Human Immunodeficiency Virus Frameshift Allows Synthesis of Viral Proteins and Virus Replication." Journal of Virology 77, no. 5 (2003): 3345–50. http://dx.doi.org/10.1128/jvi.77.5.3345-3350.2003.

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ABSTRACT Retroviruses use unusual recoding strategies to synthesize the Gag-Pol polyprotein precursor of viral enzymes. In human immunodeficiency virus, ribosomes translating full-length viral RNA can shift back by 1 nucleotide at a specific site defined by the presence of both a slippery sequence and a downstream stimulatory element made of an extensive secondary structure. This so-called frameshift mechanism could become a target for the development of novel antiviral strategies. A different recoding strategy is used by other retroviruses, such as murine leukemia viruses, to synthesize the G
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Dahari, Harel, Ruy M. Ribeiro, Charles M. Rice, and Alan S. Perelson. "Mathematical Modeling of Subgenomic Hepatitis C Virus Replication in Huh-7 Cells." Journal of Virology 81, no. 2 (2006): 750–60. http://dx.doi.org/10.1128/jvi.01304-06.

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ABSTRACT Cell-based hepatitis C virus (HCV) replicon systems have provided a means for understanding HCV replication mechanisms and for testing new antiviral agents. We describe here a mathematical model of HCV replication that assumes that the translation of the HCV polyprotein occurs in the cytoplasm, that HCV RNA synthesis occurs in vesicular-membrane structures, and that the strategy of replication involves a double-stranded RNA intermediate. Our results shed light on the intracellular dynamics of subgenomic HCV RNA replication from transfection to steady state within Huh-7 cells. We predi
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Tumer, Nilgun E., Bijal A. Parikh, Ping Li, and Jonathan D. Dinman. "The Pokeweed Antiviral Protein Specifically Inhibits Ty1-Directed +1 Ribosomal Frameshifting and Retrotransposition in Saccharomyces cerevisiae." Journal of Virology 72, no. 2 (1998): 1036–42. http://dx.doi.org/10.1128/jvi.72.2.1036-1042.1998.

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ABSTRACT Programmed ribosomal frameshifting is a molecular mechanism that is used by many RNA viruses to produce Gag-Pol fusion proteins. The efficiency of these frameshift events determines the ratio of viral Gag to Gag-Pol proteins available for viral particle morphogenesis, and changes in ribosomal frameshift efficiencies can severely inhibit virus propagation. Since ribosomal frameshifting occurs during the elongation phase of protein translation, it is reasonable to hypothesize that agents that affect the different steps in this process may also have an impact on programmed ribosomal fram
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Dinman, Jonathan D., Maria J. Ruiz-Echevarria, and Stuart W. Peltz. "Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents." Trends in Biotechnology 16, no. 4 (1998): 190–96. http://dx.doi.org/10.1016/s0167-7799(97)01167-0.

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Gunaseelan, Saravanan, Kai Zhi Wong, Nyo Min, et al. "Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection." Science Translational Medicine 11, no. 516 (2019): eaar5759. http://dx.doi.org/10.1126/scitranslmed.aar5759.

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Human enterovirus A71 (HEVA71) causes hand, foot, and mouth disease (HFMD) in young children and is considered a major neurotropic pathogen but lacks effective antivirals. To identify potential therapeutic agents against HFMD, we screened a 502-compound flavonoid library for compounds targeting the HEVA71 internal ribosome entry site (IRES) that facilitates translation of the HEVA71 genome and is vital for the production of HEVA71 viral particles. We validated hits using cell viability and viral plaque assays and found that prunin was the most potent inhibitor of HEVA71. Downstream assays affi
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Zhou, Rong, Zhao Kun Liu, Ye Ni Zhang, Jack Ho Wong, Tzi Bun Ng, and Fang Liu. "Research Progress of Bioactive Proteins from the Edible and Medicinal Mushrooms." Current Protein & Peptide Science 20, no. 3 (2019): 196–219. http://dx.doi.org/10.2174/1389203719666180613090710.

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For centuries, mushrooms have been widely used as traditional Chinese medicine in Asia. Apart from polysaccharides and some small-molecule components, such as flavones, polyphenols and terpenes, mushrooms produce a large number of pharmaceutically active proteins, which have become popular sources of natural antitumor, antimicrobial, immunoenhancing agents. These bioactive proteins include lectins, laccases, Ribosome Inactivating Proteins (RIPs), nucleases, and Fungal Immunomodulatory Proteins (FIPs). The review is to summarize the characterstics of structure and bioactivities involved in anti
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Romero-López, Cristina, Raquel Díaz-González, Alicia Barroso-delJesus, and Alfredo Berzal-Herranz. "Inhibition of hepatitis C virus replication and internal ribosome entry site-dependent translation by an RNA molecule." Journal of General Virology 90, no. 7 (2009): 1659–69. http://dx.doi.org/10.1099/vir.0.008821-0.

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Hepatitis C virus (HCV) protein synthesis is mediated by a highly conserved internal ribosome entry site (IRES), mostly located at the 5′ untranslatable region (UTR) of the viral genome. The translation mechanism is different from that used by cellular cap-mRNAs, making IRESs an attractive target site for new antiviral drugs. The present work characterizes a chimeric RNA molecule (HH363-50) composed of two inhibitors: a hammerhead ribozyme targeting position 363 of the HCV genome and an aptamer directed towards the essential stem–loop structure in domain IV of the IRES region (which contains t
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Dmitriev, S. E., D. O. Vladimirov, and K. A. Lashkevich. "A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis." Biochemistry (Moscow) 85, no. 11 (2020): 1389–421. http://dx.doi.org/10.1134/s0006297920110097.

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Abstract Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor, antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small-molecule drugs is known that specifically inhibit protein synthesis in eukaryotic cells. Many of them are well-studied ribosome-targeting antibiotics that block translocation, the peptidyl transferase center or the polypeptide exit tunnel, modulate the binding of translation machinery components to the ribosome, and induce miscoding, premature termination or stop codon readthrough. Such inhibitors are wi
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Vivanco, Jorge M., and Nilgun E. Tumer. "Translation Inhibition of Capped and Uncapped Viral RNAs Mediated by Ribosome-Inactivating Proteins." Phytopathology® 93, no. 5 (2003): 588–95. http://dx.doi.org/10.1094/phyto.2003.93.5.588.

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Ribosome-inactivating proteins (RIPs) are N-glycosidases that remove specific purine residues from the sarcin/ricin (S/R) loop of the large rRNA and arrest protein synthesis at the translocation step. In addition to their enzymatic activity, RIPs have been reputed to be potent antiviral agents against many plant, animal, and human viruses. We recently showed that pokeweed antiviral protein (PAP), an RIP from pokeweed, inhibits translation in cell extracts by binding to the cap structure of eukaryotic mRNA and viral RNAs and depurinating these RNAs at multiple sites downstream of the cap struct
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Leardkamolkarn, V., and W. Sirigulpanit. "Establishment of a Stable Cell Line Coexpressing Dengue Virus-2 and Green Fluorescent Protein for Screening of Antiviral Compounds." Journal of Biomolecular Screening 17, no. 3 (2011): 283–92. http://dx.doi.org/10.1177/1087057111426903.

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This study aimed to generate a stable cell line harboring subgenomic dengue virus replicon and a green fluorescent gene (DENV/GFP) for a cell-based model to screen anti-DENV compounds. The gene-encoding envelope protein of DENV-2 was deleted and then replaced with fragments of the GFP gene and a foot-and-mouth-disease virus 2A–derived cleavage site. The human cytomegalovirus immediate early and antisense hepatitis delta virus ribozyme sequences were added at the 5′- and 3′-ends. An internal ribosome entry site and neomycin resistance genes were placed upstream and next to the NS1 gene. The rec
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Dissertations / Theses on the topic "Antiviral agents Ribosomes"

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Law, Kin Bon. "Mechanistic study of type I ribosome-inactivating protein as anti-influenza and anti-tumour agent." HKBU Institutional Repository, 2000. http://repository.hkbu.edu.hk/etd_ra/253.

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Wilsen, Kathleen L. (Kathleen Lucy). "Investigating the introduction of a broadspectrum antiviral mechanism into grapevine." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51803.

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Thesis (MSc)--University of Stellenbosch, 2000.<br>ENGLISH ABSTRACT: Ribosome inactivating proteins (RIPs) are potent toxins produced by a wide range of evolutionarily diverse plants. These toxins cause cell death by physically dismantling ribosomal RNA and shutting down protein synthesis. They also have a strong antiviral activity. Some believe that the antiviral property of RIPs is a function of ribosomal inactivation, others believe that the two properties are unrelated. RIPs are non-specific in their antiviral activity. Transgenic RIPexpressing plants are resistant to a wide spectru
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Mansouri, Sheila. "Mutations in the ribosomal protein L3 increase resistance to pokeweed antiviral protein in vivo /." 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR19730.

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Thesis (M.Sc.)--York University, 2006. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 95-103). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR19730
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Tung, Kelvin Winyen Chan. "Ribotoxicity of pokeweed antiviral protein." 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR32030.

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Thesis (M. Sc.)--York University, 2007. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 92-98). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004 & res_dat=xri:pqdiss & rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation & rft_dat=xri:pqdiss:MR32030.
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Nourollahzadeh, Emad. "Effect of ribosomal conformation on activity of pokeweed antiviral protein in Saccharomyces cerevisiae /." 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR19667.

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Thesis (M.Sc.)--York University, 2006. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 118-125). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR19667
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Gandhi, Rikesh. "Pokeweed antiviral protein inhibits brome mosaic virus RNA3 accumulation and translation in Vivo /." 2005.

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Thesis (M.Sc.)--York University, 2005. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 88-93). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11797
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"Interaction study of ribosome-inactivating proteins (RIPs) and ribosomes and increasing the specificity of ricin A chain toward HIV-1 protease by protein engineering." 2012. http://library.cuhk.edu.hk/record=b5549526.

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核糖體抑活蛋白 (RIPs) 屬於糖苷酶的一種，能從23S或28S核糖體核糖核酸中的sarcin-ricin環(sarcin-ricin loop, SRL)移除一個特定的腺嘌呤，引致核糖體失效。由於核糖體蛋白協助RIP到達SRL，因此它們對RIP的核糖體特認性是極大的重要。雖然各RIPs的份子結構及催化活動非常相似，它們的核糖體特認性和效力存著很大的迥異。此外，現時還未能找出只有少數RIPs能同時抑制原核和真核生物的核糖體的原因。我們試圖從玉米核糖體抑活蛋白 (Maize RIP) 和真核生物的核糖體以及志賀毒素 (Shiga toxin) 和原核生物的核糖體的相互作用的研究中去解釋以上的現象。<br>我們發現Maize RIP提供一個前所未見的區域與核糖體蛋白P2結合，並展示RIPs的結構大大限制了它們與核糖體蛋白的相互作用的性質和強度，從而影響RIPs在核糖體上的效力。另外，我們發現志賀毒素跟細菌的核糖體的相互作用比跟真核生物核糖體的相互作用弱，並可能跟細菌核糖體蛋白L7/L10有交聯。我們在蓖麻毒蛋白 (Ricin) 的碳端 (C-terminus) 加上人類免疫缺陷病毒-(HIV-1) 蛋白酶特認的肽以增加 ricin 對HIV-1蛋白酶的特認性，並希望此研究結果有助於應用相類的策略到其他RIPs上。<br>Ribosome-inactivating proteins (
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"Maize ribosome-inactivating protein as an HIV-specific cytotoxin." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074900.

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In the future, the 25 as internal loop region of Pro-RIP can be modified for the optimized recognition of proteases of other HIV strains. This approach opens a new opportunity for the anti-HIV application of maize RIP and other related type III RIPs. A modified maize RIP may also be applied to target other viruses and pathogens, for examples, hepatitis C and malaria, which are dependent on pathogen-encoded proteases for replication.<br>In this study, we provide an account on the generation of HIV-1 protease-sensitive maize RIP variants by first incorporating the HIV-1 protease recognition sequ
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"Application and engineering of ribosome-inactivating proteins for targeting immunodeficiency virus." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291528.

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Ribosome-inactivating proteins (RIPs) are cytotoxins that remove a specific adenine from the sarcin-ricin loop (SRL) of large ribosomal RNA and in turn inhibit protein synthesis. Apart from N-glycosidase activity, some RIPs are found to possess antiviral activity and the suppression on human immunodeficiency virus (HIV) has been extensively studied.<br>Maize RIP stands out from other members for having an internal inactivation region and requires proteolytic removal to regain full activity. We have exploited the innate regulatory mechanism of maize RIP and increased its specificity towards HIV
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"Structural study of maize ribosome-inactivating protein and increasing its specificity towards HIV-1 protease." Thesis, 2009. http://library.cuhk.edu.hk/record=b6075321.

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As the first structural example of this class of proteins, crystals of Pro-RIP and MOD were grown and diffracted to 2.4 and 2.5 A respectively. The structures of the two proteins are solved and found to be highly similar, with main chain RMSD of 0.519. Each protein has two domains. The N-terminal domain consists of five alpha-helices and five-stranded mixed beta-sheet. The conserved active site residues Y94, Y130, E207, R210 and W241, similar to those of other RIPs, are located at the cleft between the N-terminal and C-terminal domains. In Pro-RIP, the 25-amino acid internal inactivation regio
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Book chapters on the topic "Antiviral agents Ribosomes"

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McGrath, M. S., K. C. Luk, H. D. Abrams, et al. "Antiviral Studies with Trichosanthin, A Plant Derived Single Chain Ribosome Inactivating Protein." In Natural Products as Antiviral Agents. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3414-3_9.

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