Relevant bibliographies by topics / APPswe mice

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'APPswe mice'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "APPswe mice"

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Fu, Lu, Yao Sun, Yongqing Guo, et al. "Progressive Spatial Memory Impairment, Brain Amyloid Deposition and Changes in Serum Amyloid Levels as a Function of Age in APPswe/PS1dE9 Mice." Current Alzheimer Research 15, no. 11 (2018): 1053–61. http://dx.doi.org/10.2174/1567205015666180709112327.

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Background: Mice co-expressing human amyloid precursor protein with the Swedish mutation (APPswe) and exon-9-deleted presenilin (PS1dE9) has become one of the most widely used mouse models for studying Alzheimer’s disease (AD) pathogenesis and preclinical studies of AD therapeutic approaches. Objective: In this study, we systematically investigated cognitive decline, amyloid-β (Aβ) deposition and cerebral or Aβ serum levels as well as the relationships among these measures in APPswe/PS1dE9 transgenic mice. Method: APPswe/PS1dE9 mice were separated into four equal age cohorts (4, 6, 9, and 12 m
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Rodriguez-Vieitez, Elena, Ruiqing Ni, Balázs Gulyás, et al. "Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study." Eur J Nucl Med Mol Imaging. 42, no. 7 (2015): 1119–32. https://doi.org/10.1007/s00259-015-3047-0.

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PURPOSE: Pathological studies suggest that neuroinflammation is exacerbated by increased beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and relationships between astrocytosis and Aβ deposition were examined using multitracer in vivo positron emission tomography (PET) imaging in an AD transgenic mouse model, followed by postmortem autoradiography and immunohistochemistry analysis. METHODS: PET imaging with the amyloid plaque tracer (11)C-AZD2184 and the astroglial tracer (11)C-deuterium-L-deprenyl ((11)C-DED) was carried out in APPswe mice
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Chen, Fang, Yingkun He, Pengwen Wang, et al. "Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice." International Journal of Immunopathology and Pharmacology 32 (January 1, 2018): 205873841878006. http://dx.doi.org/10.1177/2058738418780066.

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Reduced glucose utilization and deficient energy metabolism that occur in the early stages of Alzheimer’s disease correlate with impaired cognition, and this information is evidence that Alzheimer’s disease is a metabolic disease that is associated with brain insulin/insulin-like growth factor resistance. This research aimed to investigate the effects of Banxia Xiexin decoction (BXD) on cognitive deficits in APPswe/PS1dE9 double transgenic mice and verify the hypothesis that BXD treatment improves cognitive function via improving insulin signalling, glucose metabolism and synaptic plasticity i
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Lysikova, E. A., E. V. Kuzubova, A. I. Radchenko, et al. "APPswe/PS1dE9/Blg Transgenic Mouse Line for Modeling Cerebral Amyloid Angiopathy in Alzheimer’s Disease." Молекулярная биология 57, no. 1 (2023): 85–94. http://dx.doi.org/10.31857/s0026898423010081.

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Alzheimer’s disease (AD) is the most common proteinopathy, which is accompanied by a steady decrease in the patient’s cognitive functions with simultaneous accumulation of extracellular aggregates of amyloid β (Aβ) – amyloid plaques in the brain tissues and associated with neuroinflammation and neurodegeneration. Unlike humans and all other mammals, rats and mice have three amino acid substitutions in Aβ and do not reproduce the Alzheimer’s pathology. However, the appearance of amyloid plaques is observed in the brains of transgenic mice with the overexpression of human Aβ, which makes it poss
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Wang, Ruonan, Shijia Kang, Zirui Zhao, et al. "Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer’s Disease Models." International Journal of Molecular Sciences 25, no. 6 (2024): 3408. http://dx.doi.org/10.3390/ijms25063408.

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Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. The accumulation of amyloid-beta (Aβ) plaques is a distinctive pathological feature of AD patients. The aims of this study were to evaluate the therapeutic effect of chicoric acid (CA) on AD models and to explore its underlying mechanisms. APPswe/Ind SH-SY5Y cells and 5xFAD mice were treated with CA. Soluble Aβ1–42 and Aβ plaque levels were analyzed by ELISA and immunohistochemistry, respectively. Transcriptome sequencing was used to compare the changes in hippocampal gene expression profiles among the 5xFAD mou
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Stenzel, J., C. Rühlmann, T. Lindner, et al. "[18F]-florbetaben PET/CT Imaging in the Alzheimer’s Disease Mouse Model APPswe/PS1dE9." Current Alzheimer Research 16, no. 1 (2018): 49–55. http://dx.doi.org/10.2174/1567205015666181022095904.

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Background: Positron-emission-tomography (PET) using 18F labeled florbetaben allows noninvasive in vivo-assessment of amyloid-beta (Aβ), a pathological hallmark of Alzheimer’s disease (AD). In preclinical research, [<sup>18</sup>F]-florbetaben-PET has already been used to test the amyloid-lowering potential of new drugs, both in humans and in transgenic models of cerebral amyloidosis. The aim of this study was to characterize the spatial pattern of cerebral uptake of [<sup>18</sup>F]-florbetaben in the APPswe/ PS1dE9 mouse model of AD in comparison to histologically det
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Doméné, Aurélie, Chelsea Cavanagh, Guylène Page, et al. "Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer’s Disease versus Age-Matched Controls: A Presymptomatic Stage Study." International Journal of Alzheimer's Disease 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/5696241.

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Recent mouse studies of the presymptomatic stage of Alzheimer’s disease (AD) have suggested that proinflammatory changes, such as glial activation and cytokine induction, may occur already at this early stage through unknown mechanisms. Because TNFαcontributes to increased Aβproduction from the Aβprecursor protein (APP), we assessed a putative correlation between APP/Aβand TNFαduring the presymptomatic stage as well as early astrocyte activation in the hippocampus of 3-month-old APPswe/PS1dE9 mice. While Western blots revealed significant APP expression, Aβwas not detectable by Western blot or
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Tsay, Huey-Jen, Hui-Kang Liu, Yueh-Hsiung Kuo, et al. "EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways." International Journal of Molecular Sciences 22, no. 19 (2021): 10413. http://dx.doi.org/10.3390/ijms221910413.

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Alzheimer’s disease (AD) is characterized by the deposition of β-amyloid peptide (Aβ). There are currently no drugs that can successfully treat this disease. This study first explored the anti-inflammatory activity of seven components isolated from Antrodia cinnamonmea in BV2 cells and selected EK100 and antrodin C for in vivo research. APPswe/PS1dE9 mice were treated with EK100 and antrodin C for one month to evaluate the effect of these reagents on AD-like pathology by nesting behavior, immunohistochemistry, and immunoblotting. Ergosterol and ibuprofen were used as control. EK100 and antrodi
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Metaxas, Athanasios, Ramanan Vaitheeswaran, Katrine T. Jensen, et al. "Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 Month Old APPswe/PSEN1dE9 Mice." Current Alzheimer Research 15, no. 5 (2018): 420–28. http://dx.doi.org/10.2174/1567205014666171004113537.

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Background: Although mood and sleep disturbances are nearly universal among patients with Alzheimer's disease (AD), brain structures involved in non-cognitive processing remain under characterized in terms of AD pathology. Objectives: This study was designed to evaluate hallmarks of AD pathology in the brainstem of the APPswe/PS1dE9 mouse model of familial AD. Methods: Fresh-frozen sections from female, 12 month old, transgenic and control B6C3 mice (n=6/genotype) were examined for amyloid burden and neurofibrillary alterations, by using 6E10 immunohistochemistry and the Gallyas silver stain,
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Zamarbide, Marta, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, and Alberto Perez-Mediavilla. "Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer’s Disease Mouse Model." International Journal of Molecular Sciences 23, no. 7 (2022): 3533. http://dx.doi.org/10.3390/ijms23073533.

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The free fatty acid FFA3 receptor (FFA3R) belongs to the superfamily of G-protein-coupled receptors (GPCRs). In the intestine and adipose tissue, it is involved in the regulation of energy metabolism, but its function in the brain is unknown. We aimed, first, to investigate the expression of the receptor in the hippocampus of Alzheimer disease (AD) patients at different stages of the disease and, second, to assess whether genetic inactivation of the Ffar3 gene could affect the phenotypic features of the APPswe mouse model. The expression of transcripts for FFA receptors in postmortem human hip
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Dissertations / Theses on the topic "APPswe mice"

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Papadopoulos, Panayiota. "Mice co-expressing human APPSwe/Ind TGF-B1 as a tool for the identification of Alzheimer's disease therapies." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110363.

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Elevated brain levels of amyloid-β (Aβ) and transforming growth factor- β1 (TGF-β1) are thought to contribute to the cognitive and cerebrovascular alterations of Alzheimer's disease (AD). Here, we sought to investigate the role of simultaneous increases of Aβ and TGF-β1 on cerebrovascular, neuronal, glial and mnemonic function using a bitransgenic mouse model concurrently overexpressing a mutated form of the human amyloid precursor protein (APPSwe,Ind) and a constitutively active form of TGF-β1 (A/T mice). In addition, we attempted to counter these deficits using three different pharmacologica
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Ahmad, Shakeel. "The impact of pesticides on apple mite communities." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422565.

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Laboratory, field and semi-field experiments have been carried out on the predatory mites Kampimodromus aberrans, Amblyseius andersoni, Typhlodromus pyri and Phytoseius finitimus in order to optimize biological control strategies against phytophagous mites in apple orchards. The first experiment concerned the augmentative releases of K. aberrans in organic and conventional apple orchards. The most frequent insecticides used in organic orchards were pyrethrins and spinosad, whereas neonicotinoids, OPs and IGRs were used in conventional orchards. K. aberrans releases were successful and predator
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Mobley, Kendrick Norman. "Gas exchange characteristics of apple and peach leaves as influenced by European red mite and twospotted spider mite." Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/52089.

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Three densities of European red mite (ERM) (<i>Panonychus ulmi</i> Koch) and twospotted spider mite (TSM) (<i>Tetranychus urticae</i> (Koch)) were maintained on greenhouse-grown 'Imperial Delicious' apple (<i>Malus domestica</i>) and 'Redhaven' peach (<i>Prunus persica</i>) leaves. As ERM- and TSM-days increased, apple leaf net photosynthesis (Pn), transpiration (Tr) , and chlorophyll content (TCHL) decreased linearly. TSM was more damaging to apple leaf gas exchange than ERM. Apple water use efficiency (WUE) declined similarly with increasing mite-days for both mite species. Apple specific le
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Villanueva, Ra Raúl Timoteo. "Ecology of the mite complex on apple and related pest management implications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq20708.pdf.

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Cuthbertson, Andrew Garnet Steen. "The role of the predatory mite Anystis baccarum in Bramley apple orchards." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326402.

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Rogers, Richard E. L. "Insect and mite monitoring in commercial apple orchards in Nova Scotia (1979-1985)." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65368.

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Ogura, Kasane. "Oral Administration of Apple Procyanidins Ameliorates Insulin Resistance via Suppression of Pro-inflammatory Cytokines Expression in Liver of Diabetic ob/ob Mice." Kyoto University, 2017. http://hdl.handle.net/2433/225979.

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Campbell, Richard John. "Effect of nitrogen fertilization on the physiological damage and subsequent recovery of mite-infested apple leaves /." This resource online, 1988. http://scholar.lib.vt.edu/theses/available/etd-04122010-083649/.

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Campbell, Richard J. "Effect of nitrogen fertilization on the physiological damage and subsequent recovery of mite-infested apple leaves." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/42042.

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Two experiments were conducted with field- and container-grown 'Delicious' apple trees to evaluate the effect of nitrogen fertilization on the physiology of apple leaves subjected to European red mite feeding, and the subsequent recovery of leaf function following mite removal. Nitrogen (N) fertilization affected the visual damage, and the photosynthetic response of 'Imperial Delicious' apple leaves to mite feeding. Visual damage occurred first, and remained greatest on the low N treatment throughout the experiment. High N trees exhibited a linear decline in Pn with increasing MD, in contras
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Fitzgerald, Jean D. "Resistance to organophosphorus insecticides in the predatory mite Typhlodromus pyri Scheuten (Acarina: Phytoseiidae), an important biocontrol agent in apple orchards." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298983.

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Books on the topic "APPswe mice"

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Butler, Stephen. The mouse and the apple. Frances Lincoln, 1994.

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Langston, Laura. Mile-high apple pie. Bodley Head, 2004.

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V, Suteev, ed. That apple is mine! Holiday House, 2000.

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Stephen, Butler. The Mouse and the Apple. Francis Lincoln, 1994.

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Benjamin, A. H. Little Mouse and the big red apple. Tiger Tales, 2001.

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Benjamin, A. H. Little Mouse and the big red apple. Little Tiger Press, 2001.

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ill, Williamson Gwyneth 1965, ed. Little Mouse and the big red apple. Scholastic Inc., 2001.

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Bruno, Anthony. Bad apple: A novel. Delacorte Press, 1994.

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Kroll, Steven. The biggest apple ever. Cartwheel Books, 2011.

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Bono, Bill. Microsoft Multiplan: of mice and menus: Models for managing our business with the Apple Macintosh. Microsoft Press, 1985.

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Book chapters on the topic "APPswe mice"

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Hangay, George, Severiano F. Gayubo, Marjorie A. Hoy, et al. "Apple Rust Mite, Aculus Schlechtendali (Acarnia: Eriophyidae)." In Encyclopedia of Entomology. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_10314.

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Wollkind, David, and Bonni Dichone. "Temperature-Dependent Predator-Prey Mite Interaction on Apple Tree Foliage: Dynamical Systems Analysis." In Pulling Rabbits Out of Hats. CRC Press, 2021. http://dx.doi.org/10.1201/9781003195603-4.

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Sharma, Sangita, and S. P. Bhardwaj. "Effect of nitrogen, phosphorus, and potash levels on population fluctuation of European red mite, Panonychus ulmi, on apple." In Trends in Acarology. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9837-5_84.

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Heckmann, Rebecca, Sören Kock, and Lutz Gaspers. "Artificial Intelligence Supporting Sustainable and Individual Mobility: Development of an Algorithm for Mobility Planning and Choice of Means of Transport." In iCity. Transformative Research for the Livable, Intelligent, and Sustainable City. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92096-8_3.

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AbstractMobility planning is rarely individually tailored. Instead people have to make an active effort to adapt standard solutions to their requirements. Routing apps like Google Maps allow for personalization only by saving important places like home and a workplace but do not allow the user to influence the routing suggestions or choice of mode of transport based on preferences, limitations, or situation. It becomes even more difficult when different means of transport are to interact since most routing applications offer very little multimodal optimization aside from the last mile. Thus, t
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"First Development: From Apple Orchards to Building Lots." In Montreal's Square Mile. University of Toronto Press, 2024. https://doi.org/10.3138/9781487537456-005.

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"Unblock Me – Block mich frei." In Aktivieren mit Apps. Vincentz Network, 2022. http://dx.doi.org/10.1515/9783748606536-058.

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"Integrated Mite Management in Washington Apple Orchards." In Agricultural Acarology. CRC Press, 2011. http://dx.doi.org/10.1201/b10909-21.

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Rogovoy, Seth. "Brothers in Arms." In Within You Without You. Oxford University PressNew York, 2025. http://dx.doi.org/10.1093/oso/9780197627822.003.0033.

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Abstract Chapter 32 of Within You Without You, “Brothers in Arms,” examines George Harrison’s penchant for writing songs about the Beatles, during his years with the band and then in his subsequent solo career. While he was still in the group, songs that included “Savoy Truffle,” “I Me Mine,” and “Only a Northern Song” alluded to the internal dynamics among the band members. Harrison’s debut solo album, All Things Must Pass, included several songs that seemed to be addressed to his former bandmates, including “Run of the Mill,” “Isn’t It a Pity,” and “Apple Scruffs.” Sometimes the songs did li
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"An Increase in Aβ42 in the Prefrontal Cortex is Associated with a Reversal Learning Impairment in Alzheimer’s Disease Model Tg2576 APPsw Mice." In Advances in Alzheimer Research, edited by Jia-Min Zhuo, Annamalai Prakasam, Melissa E. Murray, et al. BENTHAM SCIENCE PUBLISHERS, 2013. http://dx.doi.org/10.2174/9781608054954113010006.

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Deng Yihan, Bürkle Thomas, Holm Jürgen, Zetz Erwin, and Denecke Kerstin. "Last Mile Towards Efficient Healthcare Delivery in Switzerland: eHealth Enabled Applications Could Speed Up the Care Process." In Studies in Health Technology and Informatics. IOS Press, 2018. https://doi.org/10.3233/978-1-61499-852-5-251.

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A precise and timely care delivery depends on an efficient triage performed by primary care providers and smooth collaboration with other medical specialities. In recent years telemedicine gained increasing importance for efficient care delivery. It's use, however, has been limited by legal issues, missing digital infrastructures, restricted support from health insurances and the digital divide in the population. A new era towards eHealth and telemedicine starts with the establishment of national eHealth regulations and laws. In Switzerland, a nation-wide digital infrastructure and electronic
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Conference papers on the topic "APPswe mice"

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Abd-Elrahman, Khaled, Tash-Lynn L. Colson та Stephen S. Ferguson. "A positive allosteric modulator of M1 Acetylcholine receptors improves cognitive deficits in male and female APPswe/PSEN1ΔE9 mice via divergent mechanisms". У ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.138300.

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Antoni, Agustika, Nicen Suherlin, and Sri Oktarina. "The Effect of Apple Guava Juice on Macrophages Level in Mice Wound on Fifth Day." In 1st International Conference on Health Sciences and Biotechnology (ICHB 2021). Atlantis Press, 2022. http://dx.doi.org/10.2991/ahsr.k.220303.003.

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Jidong Lv, De-an Zhao, Wei Ji, Yu Chen, and Ying Zhang. "Research on trunk and branch recognition method of apple harvesting robot." In 2012 International Conference on Measurement, Information and Control (MIC). IEEE, 2012. http://dx.doi.org/10.1109/mic.2012.6273345.

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Baranafe, Pelalgia, Herianus Lalel, and Ina Debora. "Antifertility Effect of Sugar Apple Seed Extract (Annona Squamosa) with Ethanol Solution in Female White Mice." In The 6th International Conference on Public Health 2019. Masters Program in Public Health, Graduate School, Universitas Sebelas Maret, 2019. http://dx.doi.org/10.26911/the6thicph.05.02.

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Wahab, Siti Norida. "Transforming Malaysian On-Demand Delivery Apps for Efficient Last-Mile Delivery: A SWOT Analysis." In 2021 International Conference on Data Analytics for Business and Industry (ICDABI). IEEE, 2021. http://dx.doi.org/10.1109/icdabi53623.2021.9655884.

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Abderrahim, Mohamed, Luis Condezo-Hoyos, Noemí León Roque, and Silvia M. Arribas. "Predicción del índice de fermentación de cacao (Theobroma cacao L.) mediante análisis de imagen y redes neuronales." In Actas de las XXXVII Jornadas de Automática 7, 8 y 9 de septiembre de 2016, Madrid. Universidade da Coruña, Servizo de Publicacións, 2022. http://dx.doi.org/10.17979/spudc.9788497498081.1156.

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En el presente estudio se desarrolló y validó un método de predicción del índice de fermentación de granos de cacao usando visión por computador y redes neuronales. El índice fermentación es un indicador de la calidad organoléptica de los granos procesados de cacao. Este control habitualmente se realiza en lotes de granos fermentados mediante la técnica Cut-Test que mide de manera subjetivamente el color. Se implementaron seis modelos de predicción empleando valores de RGB de la superficie y de la parte media de los granos de cacao y de los extractos alcalinos. El índice de fermentación de cac
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Reports on the topic "APPswe mice"

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Elmann, Anat, Orly Lazarov, Joel Kashman, and Rivka Ofir. therapeutic potential of a desert plant and its active compounds for Alzheimer's Disease. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7597913.bard.

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We chose to focus our investigations on the effect of the active forms, TTF and AcA, rather than the whole (crude) extract. 1. To establish cultivation program designed to develop lead cultivar/s (which will be selected from the different Af accessions) with the highest yield of the active compounds TTF and/or achillolide A (AcA). These cultivar/s will be the source for the purification of large amounts of the active compounds when needed in the future for functional foods/drug development. This task was completed. 2. To determine the effect of the Af extract, TTF and AcA on neuronal vulnerabi
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