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Dissertations / Theses on the topic 'Arrhythmic syndrome'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Raju, Hariharan. "Sudden arrhythmic death syndrome : underlying cardiological, pathological and genetic aetiology." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656852.

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BACKGROUND: Sudden arrhythmic death syndrome (SADS) describes sudden, premature and unexpected deaths, which remain unexplained despite autopsy. Approximately one-third of SADS relates to inherited conditions such as Brugada syndrome (BrS), long QT syndrome (LQT) and catecholaminergic polymorphic ventricular tachycardia (CPVT). AIMS: We aimed to evaluate clinical utility for novel histopathological and genetic molecular investigation following SADS. METHODS: SADS cases were investigated by: [1] morphometric analysis of picrosirius-red histological myocardial staining; [2] a novel enrichment (F

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2

Matthews, Gareth David Kingsley. "The rate-dependence of pro-arrhythmic properties in murine SCN5A+/- hearts modeling the Brugada syndrome." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648741.

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3

Сміян, Олександр Іванович, Александр Иванович Смиян, Oleksandr Ivanovych Smiian та ін. "Вегетативная регуляция сердечного ритма у детей с малыми аномалиями серца". Thesis, Издательство СумГУ, 2010. http://essuir.sumdu.edu.ua/handle/123456789/6127.

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4

Behr, Elijah Raphael. "Sudden arrhythmic death syndrome : an epidemiological and pathological phenomenon and its clinical and genetic implications." Thesis, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416571.

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5

Goldsworthy, Christopher. "Genetic testing for sudden arrhythmic death syndrome and the coroners' system of England and Wales." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/97980/.

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The author of this thesis examines how SADS is made and remade within interdisciplinary professional practice. Whilst recent sociological scholarship has followed the discourse of ‘molecularization’ when examining the construction of biomedical categories, I instead place the genetic as part of a broader clinical and medico-legal system. Whilst it is accepted that there are genetic aspects of SADS this does not reduce the usefulness of other disciplinary explanations in practice. This thesis is situated around the molecular autopsy, a technology simultaneously employed to identify the cause of

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6

Papadakis, Michael. "Sudden arrhythmic death syndrome in the UK : the experience of a tertiary cardiogenetics centre in South London." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/sudden-arrhythmic-death-syndrome-in-the-uk(6b89384a-1ba9-42a7-bc44-c58d65d2461a).html.

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Background: In a proportion of sudden cardiac deaths (SCD), no structural pathology can be identified and a diagnosis of sudden arrhythmic death syndrome (SADS) is advocated. Recognition of SADS is important since a significant proportion is attributed to inherited cardiac conditions, and evaluation of relatives may identify individuals at risk. Aims: The aims of the thesis are: To investigate the magnitude of SADS in young (≤35 years) and athletic individuals; To investigate the impact of expert cardiac pathology; To evaluate a large cohort of SADS families to ascertain: 1.The diagnostic yiel

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7

Bakshi, Ruchika. "Asymptomatic long QT syndrome : a qualitative exploration of adolescent and parent experiences of living with the risk of a sudden arrhythmic death." Thesis, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583261.

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The sudden death of a' child is a risk that families with Long O'T syndrome face. Preliminary research has shown that young people and their families with both Long O'T syndrome and asymptomatic Long O'T syndrome are at risk of developing psychological difficulties. To date however, the psychological processes that mediate the challenges associated with Long O'I syndrome within the context of adolescent development have not been fully explored. The present study conducted in-depth individual interviews with five young people aged between 12 and 15 years with a diagnosis of asymptomatic Long O'

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8

Gray, Belinda Ruth. "Clinical and Genetic Studies in Inherited Arrhythmia Syndromes." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15994.

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Inherited arrhythmia syndromes, or “ion channelopathies”, is a term encompassing a number of different diseases including long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome (BrS), short QT syndrome (SQTS) and idiopathic ventricular fibrillation (IVF). In inherited arrhythmia syndromes, ventricular arrhythmias originate due to abnormalities with intracellular ion channels, predominantly involving potassium, sodium and calcium handling, due to genetic mutations in genes encoding for channel proteins. The cellular abnormalities in these conditi

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9

Martin, Claire Adriana. "Mechanisms of arrhythmogenesis in a murine model of Brugada syndrome." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648347.

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10

Cross, Stephen. "Phenotypic heterogeneity in the Romano-Ward syndrome." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295289.

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The Romano-Ward syndrome is a familial disorder inherited as an autosomal dominant trait, the gene of which has been linked to the HLA locus on chromosome 6 or the Harvey-ras oncogene on chromosome 11. The genetic linkage, left and right ventricular function, and the integrity of the baroreflex were studied in subjects from two unrelated families with this condition. Neither family showed genetic linkage to either the HLA locus or to the Harvey-ras gene. Blood pool tomography was used to assess left and right ventricular function: left ventricular wall motion abnormalities were seen only in on

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11

Liu, Pak-yin Anthony, and 廖柏賢. "Genetic counseling in sudden arrhythmia death syndrome : the science and the art." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196059.

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Background: Sudden arrhythmia death syndrome (SADS) is a genotypically and phenotypically heterogeneous condition that might produce fatal ventricular arrhythmia in otherwise healthy individuals. Congenital long QT syndrome (LQTS) is the most common type of SADS with a frequency of 1 in 2500 individuals. Up to 13 genes have been shown to be associated with LQTS and genetic testing has a role in disease diagnosis, prognostication, treatment guidance, cascade testing, and reproductive counseling. Interdisciplinary care is the standard but such service is unavailable in Hong Kong. Objectives:

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12

MALERBA, NATASCIA. "Dissecting the IDDCA (Intellectual Developmental Disorder with Cardiac Arrhythmia) syndrome pathogenic mechanisms." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382262.

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La sindrome genetica rara da disabilità intellettiva e disturbo del ritmo cardiaco (acronimo: IDDCA, MIM # 617173) è una malattia multi-sistemica a trasmissione autosomica recessiva con esordio precoce, associata a varianti patogenetiche nel gene GNB5. Il quadro delle manifestazioni cliniche varia da una forma più grave caratterizzata da ritardo nello sviluppo psicomotorio, disabilità intellettiva, encefalopatia epilettica, anomalie visive e aritmie cardiache (IDDCA), a una forma più lieve associata al ritardo del linguaggio, disturbo da deficit di attenzione, deficit cognitivo, in presenza o

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13

FROSIO, ANTHONY. "FUNCTIONAL CHARACTERIZATION OF NEW SCN5A MUTATIONS ASSOCIATED WITH DIFFERENT PATTERNS OF ARRHYTHMIA." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/699108.

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During my Ph.D, I have been mainly involved in two projects regarding the role of pathological mutations of cardiac voltage-gated sodium channel (NaV1.5). In the first study I dealt with characterizing a new heterozygous mutation (S805L) found in a Brugada syndrome (BrS) patient, while in the second study, I functional characterized a compound heterozygous mutation (K1578N/ G1866fs) found in a two-year old patient affected by severe bradycardia and recurrent atrial flutter. Both lines of research were carried out using HEK293 cell as experimental model to express both Wild-Type and mutant mode

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14

Bartos, Daniel C. "Mechanistic Basis for Atrial and Ventricular Arrhythmias Caused by KCNQ1 Mutations." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/8.

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Cardiac arrhythmias are caused by a disruption of the normal initiation or propagation of electrical impulses in the heart. Hundreds of mutations in genes encoding ion channels or ion channel regulatory proteins are linked to congenital arrhythmia syndromes that increase the risk for sudden cardiac death. This dissertation focuses on how mutations in a gene (KCNQ1) that encodes a voltage-gated K+ ion channel (Kv7.1) can disrupt proper channel function and lead to abnormal repolarization of atrial and ventricular cardiomyocytes. In the heart, Kv7.1 coassembles with a regulatory protein to condu

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15

Chai, Shin Luen Chai. "Novel Genetic Modifiers in a Monogenic Cardiac Arrhythmia." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1516618028568975.

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16

Adeniran, Ismail. "Biophysically detailed modelling of the functional impact of gene mutations associated with the 'short QT syndrome'." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/biophysically-detailed-modelling-of-the-functional-impact-of-gene-mutations-associated-with-the-short-qt-syndrome(f602c1f4-4290-469e-a66a-878198b17c7d).html.

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The recently identified genetic short QT syndrome is characterised by abbreviated QT intervals on the electrocardiogram, an increased risk of atrial and ventricular arrhythmias, and an increased risk of sudden death. Although the short QT syndrome has been suggested to provide a paradigm for increasing understanding of the role of potassium channels in ventricular fibrillation, the basis for arrhythmogenesis in the short QT syndrome is incompletely understood. There are no animal models that accurately reproduce a short QT phenotype, and whilst in vitro electrophysiology of short QT mutant cha

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17

Hoshi, Malcolm. "Unveiling Mechanisms Involved in Non-Traditional Cases of Inherited Cardiac Channelopathies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1434188844.

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18

Anttonen, O. (Olli). "Prevalence, prognosis and characteristics of subjects with short QT interval in an electrocardiogram." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514290077.

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Abstract Short QT syndrome is an inherited arrhythmia disorder characterized by a short QT interval, typical T-wave and ST-segment morphology and an increased risk of sudden cardiac death. The purpose of this thesis was to study the epidemiology and prognosis of the subjects with short QT intervals. Special attention was paid to the ECG changes that could illustrate the prognosis of subjects with short QT interval. The first study comprised a group of patients with short QT syndrome. We report clinical presentation, ECG morphology, the prevalence of genetic mutations and the results of thera

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19

Myers, Katherine Joyce. "Acceptability and Familiarity of Genetic Treatment Technologies: A Survey of Individuals with Sudden Arrhythmia Death Syndrome (SADS) Conditions." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1554993385165476.

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20

Shinlapawittayatorn, Krekwit. "Modulations of Sodium Channel Long QT and Brugada Syndrome Mutations by a Common Sodium Channel Polymorphism." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1315329659.

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21

Paech, Christian, Franziska Wagner, Philipp Suchowerskyj, and Michael Weidenbach. "The blue child – amiodarone-induced blue-gray skin syndrome and pulmonary mass in a child." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205291.

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Adverse effects of amiodarone are rarely seen in pediatric patients, but may occur if amiodarone is applied for long-term treatment. Two rather rare phenomena are blue-gray skin pigmentation and pulmonary mass. They represent important differential diagnoses from more common clinical complications like pneumonia and drug-induced toxic skin lesions.

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22

Siebert, Jost. "How might we create a more realistic ECG Training?" Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125680.

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Electrocardiography (ECG or EKG) is the process of recording the electrical activity of the heart over a period of time using electrodes placed on a patient’s body. These electrodes detect the tiny electrical changes on the skin that arise from the heart muscle depolarizing during each heartbeat. [1] It is necessary for the diagnosis and prompt initiation of therapy in patients with acute coronary syndromes (ACS) and is the most accurate means of diagnosing conduction disturbances and arrhythmias. [2]ECG is an irreplaceable diagnostic method in clinical practice. It offers great diagnostic val

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23

Takaki, Tadashi. "Optical recording of action potentials in human induced pluripotent stem cell-derived cardiac single cells and monolayers generated from long QT syndrome type 1 patients." Kyoto University, 2019. http://hdl.handle.net/2433/242346.

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24

Hirose, Sayako. "Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265195.

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25

SALA, LUCA. "Long QT Syndrome modelled with human induced pluripotent stem cells (hiPSc)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/55330.

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Cardiac arrhythmias arise when the myocardium is electrically unstable. They represent a life-threatening phenomena with more than 300,000 people dying every year for arrhythmic sudden cardiac death (SCD) only in the United States. One of the most important and well described arrhythmic condition is the Long QT Syndrome (LQTS). LQTS is an heterogeneous disorder of myocardial repolarization characterized by a prolongation of QT interval on the electrocardiogram and clinically manifested with syncopal episodes and SCD. Mutations in 13 genes regulating cardiac action potential (AP) have been foun

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26

Fang, Fang. "Gain-of-function mutations in SCN5A gene lead to type-3 long QT syndrome." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1354056382.

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27

Doinoff, Cassandra. "Sex and Regional Differences in L-type Calcium Current Distribution in Adult Rabbit Right Ventricle: Influence Action Potential Duration and the Propensity for Cardiac Arrhythmia." Youngstown State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288359312.

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28

Margara, Francesca. "Elucidating the phenotypic variability of a single cardiac sodium channel mutation: a multiscale computational approach." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15563/.

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Descritta per la prima volta nel 1999, la mutazione SCN5A-1795insD compromette l'inattivazione veloce della corrente del sodio e ne riduce drasticamente il picco. Ciò si riflette in una insolita combinazione di sintomi tipici delle sindromi long-QT-tipo 3 e Brugada (BrS). Attualmente si registrano ancora numerose questioni irrisolte relative agli aspetti biofisici di questa condizione e alla variabilità fenotipica attraverso cui questa patologia si manifesta. Utilizzando un approccio computazionale e multi-scala abbiamo acquisito una conoscenza più approfondita circa questa condizione potenz

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29

Ziyadeh, Azza. "Nouveaux mécanismes contribuant à la variabilité phénotypique de mutations N- et C-terminales du canal sodique cardiaque." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-01037923.

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Les mutations du gène SCN5A, codant la sous-unité ? du canal Na+ cardiaque Nav1.5, sont responsables d'arythmies cardiaques héréditaires. La pénétrance incomplète observée dans ces maladies suggère l'existence d'autres facteurs modulant le phénotype associé à ces mutations. Dans ce travail de thèse, nous avons caractérisé deux mutations identifiées dans SCN5A. Le mutant R104W, identifié chez un patient atteint du syndrome de Brugada, est retenu dans le réticulum endoplasmique (RE), dégradé par le protéasome et abolit le courant Na+. Co-exprimé avec le canal sauvage, R104W conduit à la rétentio

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30

Hedley, Paula Louise. "Molecular and functional characterisation of Long QT Syndrome causing genes." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86480.

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Thesis (PhD)-- Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Ventricular arrhythmias are the most important cause of sudden cardiac death (SCD) among adults living in industrialised nations. Genetic factors have substantial effects in determining population-based risk for SCD and may also account for inter-individual variability in susceptibility. Great progress has been made in identifying genes underlying various Mendelian disorders associated with inherited arrhythmia susceptibility. The most well studied familial arrhythmia syndrome is the congenital long QT syndrome (LQTS) caused by

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31

Winbo, Annika. "Long QT syndrome in Sweden : founder effects and associated cardiac phenotypes." Doctoral thesis, Umeå universitet, Pediatrik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57724.

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Background: We aimed to increase the knowledge regarding the familial arrhythmogenic disorder Long QT Syndrome (LQTS) and its recessive variant Jervell and Lange-Nielsen Syndrome (JLNS) in Sweden, including prevalences and clinical phenotypes. A specific focus was directed towards two KCNQ1 mutations –p.Y111C and p.R518X- commonly identified in Swedish LQTS index cases. Methods: Cases and families with LQTS (p.Y111C or p.R518X) and JLNS were recruited via regional clinical practices, national referrals to the Clinical Genetics laboratory, Umeå University Hospital, and a national inventory. Mol

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32

Tran, Hoang V. "Ventricular Arrhythmias Complicating Coronary Artery Disease: Recent Trends, Risk Associated with Serum Glucose Levels, and Psychological Impact." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/980.

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Introduction: Ventricular arrhythmias (VAs) are common after an acute coronary syndrome (ACS) and are associated with worse clinical outcomes. However, little is known about recent trends in their occurrence, their association with serum glucose levels, and their psychological impact in ACS setting. Methods: We examined 25-year (1986-2011) trends in the incidence rates (IRs) and hospital case-fatality rates (CFRs) of VAs, and the association between serum glucose levels and VAs in patients with an acute myocardial infarction (AMI) in the Worcester Heart Attack Study. Lastly, we examined the re

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33

Ferrand, Marine. "Étude du canal sodique cardiaque dans un modèle murin de troubles du rythme pour une nouvelle approche thérapeutique." Electronic Thesis or Diss., Sorbonne université, 2025. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2025SORUS020.pdf.

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Les arythmies cardiaques héréditaires sont généralement causées par des mutations dans les gènes codant pour des canaux ioniques ou leurs protéines partenaires. Parmi ces gènes, SCN5A, qui code la sous-unité α du canal sodique cardiaque Nav1.5, joue un rôle central dans la régulation de l'excitabilité cardiaque. Les mutations perte-de-fonction de SCN5A sont impliquées dans environ 20 % des cas de SBr, une arythmie cardiaque rare caractérisée par un risque élevé de mort subite due à une fibrillation ventriculaire. Les options thérapeutiques actuelles du SBr, traitent les symptômes et présentent

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34

Michel, Cindy. "Caractérisation et modulation du substrat de repolarisation et de l’arythmogénicité dans le ventricule droit porcin." Thesis, Bordeaux, 2021. http://www.theses.fr/2021BORD0059.

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Le ventricule droit (VD), et notamment l’infundibulum pulmonaire, est l’origine anatomique de troubles du rythme ventriculaire en conditions idiopathiques ou pathologiques. La raison et les mécanismes par lesquels le VD apparait comme une origine préférentielle de ces arythmies, demeurent mal compris. Dans ce contexte, le rôle potentiel du substrat de repolarisation dans l’arythmogénicité de la région a été étudié. Ce substrat a été caractérisé fonctionnellement par cartographie optique de l’activité électrique de VD porcins isolés et perfusés, et sur le plan moléculaire par western blot. Les

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35

Ziyadeh, Azza. "Nouveaux mécanismes contribuant à la variabilité phénotypique de mutations N- et C-terminales du canal sodique cardiaque." Electronic Thesis or Diss., Paris 6, 2014. http://www.theses.fr/2014PA066070.

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Les mutations du gène SCN5A, codant la sous-unité ? du canal Na+ cardiaque Nav1.5, sont responsables d'arythmies cardiaques héréditaires. La pénétrance incomplète observée dans ces maladies suggère l'existence d'autres facteurs modulant le phénotype associé à ces mutations. Dans ce travail de thèse, nous avons caractérisé deux mutations identifiées dans SCN5A. Le mutant R104W, identifié chez un patient atteint du syndrome de Brugada, est retenu dans le réticulum endoplasmique (RE), dégradé par le protéasome et abolit le courant Na+. Co-exprimé avec le canal sauvage, R104W conduit à la rétentio

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36

Araújo, Cristiana Marques de. "Relação entre apnéia do sono, isquemia miocárdica, variabilidade da freqüência cardíaca e arritmias em portadores de doença arterial coronária." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-28012008-133700/.

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Introdução: É comum a associação entre apnéia do sono e a doença arterial coronária (DAC), devido a fatores predisponentes comuns como sexo masculino e obesidade. Entretanto, ainda não existe uma definição objetiva da relação entre apnéia e DAC. Objetivo: Avaliar se os episódios de isquemia miocárdica, a variabilidade da freqüência cardíaca (VFC) e as arritmias cardíacas de portadores de DAC sofrem alteração na presença da apnéia do sono. Métodos: Cinqüenta e três pacientes portadores de DAC foram submetidos à monitorização eletrocardiográfica ambulatorial de 48 horas e ao estudo do sono na pr

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37

Champ-Rigot, Laure. "Nouvelles perspectives diagnostiques et thérapeutiques dans la prise en charge rythmologique des patients en situation d'insuffisance cardiaque Rationale and Design for a Monocentric Prospective Study: Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction (SAPAAD Study) Usefulness of sleep apnea monitoring by pacemaker sensor in elderly patients with diastolic dysfunction : the SAPAAD Study Clinical outcomes after primary prevention defibrillator implantation are better predicted when the left ventricular ejection fraction is assessed by magnetic resonance imaging Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study Comparison between novel and standard high-density 3D electro-anatomical mapping systems for ablation of atrial tachycardia Safety and acute results of ultra-high density mapping to guide catheter ablation of atrial arrhythmias in heart failure patients Long-term clinical outcomes after catheter ablation of atrial arrhythmias guided by ultra-high density mapping system in heart failure patients." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC430.

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L’insuffisance cardiaque est un problème de santé publique dans les pays développés, touchant 1 à 2% de la population générale, mais dont la prévalence atteint 10% après 70 ans. Les progrès thérapeutiques ont permis d’améliorer le pronostic des patients, notamment ceux ayant une altération de la fonction systolique ventriculaire gauche. Les troubles du rythme sont fréquents et nécessitent une pris en charge particulière au cours des situations d’insuffisance cardiaque. Cependant, il reste des questions non résolues : comment améliorer l’efficacité du traitement de l’insuffisance cardiaque à fo

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38

Wilson, Mathew. "Athletes' heart and exercise related sudden cardiac death : across the age span." Thesis, University of Wolverhampton, 2010. http://hdl.handle.net/2436/122548.

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Background - Regular exercise reduces the risk of cardiovascular disease and subsequent sudden cardiac death (SCD). However, a small, but notable proportion of athletes die suddenly due to inherited or congenital disorders of the heart that predispose to malignant ventricular arrhythmias. Such tragedies are highly publicised, particularly when high-profile athletes are involved. To date, limited evidence for the efficacy of cardiovascular pre-participation screening exists outside of the Italian experience. Furthermore, limited data exists examining the impact of ethnicity on cardiac adaptatio

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Cano, García Jordi. "Prediction of the effects of drugs on cardiac activity using computer simulations." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/164094.

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[ES] Las enfermedades cardiovasculares siguen siendo la principal causa de muerte en Europa. Las arritmias cardíacas son una causa importante de muerte súbita, pero sus mecanismos son complejos. Esto denota la importancia de su estudio y prevención. La investigación sobre electrofisiología cardíaca ha demostrado que las anomalías eléctricas causadas por mutaciones que afectan a canales cardíacos pueden desencadenar arritmias. Sorprendentemente, se ha descubierto una gran variedad de fármacos proarrítmicos, incluidos aquellos que usamos para prevenirlas. Las indicaciones de uso de fármacos actu

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40

Morand, Jessica. "Dysfonction cardiovasculaire et arythmies ventriculaires de l’ischémie-reperfusion : effets délétères de l’hypoxie intermittente et protecteurs de la supplémentation en zinc." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV015/document.

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Le syndrome d’apnées obstructives du sommeil (SAOS) est associé à une forte morbi-mortalité cardiovasculaire. L’hypoxie intermittente (HI), conséquence majeure des apnées, est à l’origine d’un stress oxydant, d’une activation de HIF-1 (hypoxia inducible factor 1) et d’une expression d’endothéline (ET-1), tous impliqués dans les complications cardiovasculaires liées à l’HI.Dans un premier temps, nous avons démontré que l’HI augmentait l’incidence des arythmies ventriculaires létales associées à l’ischémie myocardique. Parmi les mécanismes potentiels impliqués, l’analyse spectrale de la variabil

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Robey, Seth Hamilton. "Mechanisms of Mutation-Specific Inhibition of Late Na+ Current in Long QT Syndrome Type 3." Thesis, 2017. https://doi.org/10.7916/D8CC1192.

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The mechanical contraction of the heart is tightly coupled to rapid and concerted electrical excitation of the cardiac muscle. This electrical activity is facilitated by a highly synchronized conduction system consisting of channels, pumps, and transporters that facilitate the flow of charged ions between cellular compartments, the cytoplasm, and the interstitial fluid between cells. The biophysical properties of these membrane proteins have been studied for many years, but their role in the generation of potentially lethal cardiac arrhythmias and their interactions with drugs remains an impor

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Fernandes, Diogo Filipe de Almeida Ferreira. "Adequation of the therapeutic profile, co-morbidities and personal habits of Brugada patients with ICD and its link to dysrhythmic events." Master's thesis, 2018. http://hdl.handle.net/10316/82021.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: A síndrome de Brugada é uma doença hereditária associada a um aumento do risco de morte súbita com possível necessidade de colocação de cardioversor-desfibrilhador implantável (CDI) de forma a interromper os eventos disrítmicos. Os nossos objetivos foram identificar possíveis desencadeadores de terapias apropriadas do CDI em doentes com síndrome de Brugada e avaliar se o perfil terapêutico passado e atual é adequado à doença.Métodos: Um total de 30 doentes com síndrome de Brugada submetidos a im

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Damke, Dierk [Verfasser]. "Der Effekt parasympathischer Stimulation auf die Entstehung von Arrhythmien beim langen QT-Syndrom-Typ 3 / vorgelegt von Dierk Damke." 2009. http://d-nb.info/999595466/34.

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Silva, José Diogo Ramalho e. "Drug-induced potentially fatal arrhythmias and sudden cardiac death: a clinical perspective of long QT, short QT and Brugada syndromes." Master's thesis, 2017. https://hdl.handle.net/10216/104358.

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Silva, José Diogo Ramalho e. "Drug-induced potentially fatal arrhythmias and sudden cardiac death: a clinical perspective of long QT, short QT and Brugada syndromes." Dissertação, 2017. https://hdl.handle.net/10216/104358.

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Rosa, João Pedro Borges. "Repolarização Precoce e Morte Súbita Cardíaca: qual a associação?" Master's thesis, 2017. http://hdl.handle.net/10316/81841.

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Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>O padrão de repolarização precoce é uma entidade eletrocardiográfica recentemente redefinida pela presença de uma elevação do ponto J ≥ 0,1 milivolts em pelo menos duas derivações contíguas inferiores e/ou laterais, apresentando-se como um entalhe ou empastamento na parte terminal do complexo QRS.Ainda que a definição utilizada até 2008 fosse diferente, existia algum consenso na literatura sobre o facto do padrão de repolarização precoce ser uma variante clinicamente benigna, pelo que aquando da sua id

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Junge, Marina. "Prozess- und Diagnosequalität in Präklinik und Notaufnahme des Universitätsklinikums Göttingen." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AFB1-1.

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Raad, Nour. "NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5E72-F.

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(10724028), Jason David Ummel. "NONINVASIVE MEASUREMENT OF HEARTRATE, RESPIRATORY RATE, AND BLOOD OXYGENATION THROUGH WEARABLE DEVICES." Thesis, 2021.

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<p>The last two decades have shown a boom in the field of wearable sensing technology. Particularly in the consumer industry, growing trends towards personalized health have pushed new devices to report many vital signs, with a demand for high accuracy and reliability. The most common technique used to gather these vitals is photoplethysmography or PPG. PPG devices are ideal for wearable applications as they are simple, power-efficient, and can be implemented on almost any area of the body. Traditionally PPGs were utilized for capturing just heart rate, however, recent advancements in hardware

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