Academic literature on the topic 'Aryl ligands'

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Journal articles on the topic "Aryl ligands"

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Shaughnessy, Kevin H. "Monodentate Trialkylphosphines: Privileged Ligands in Metal-catalyzed Crosscoupling Reactions." Current Organic Chemistry 24, no. 3 (2020): 231–64. http://dx.doi.org/10.2174/1385272824666200211114540.

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Phosphines are widely used ligands in transition metal-catalyzed reactions. Arylphosphines, such as triphenylphosphine, were among the first phosphines to show broad utility in catalysis. Beginning in the late 1990s, sterically demanding and electronrich trialkylphosphines began to receive attention as supporting ligands. These ligands were found to be particularly effective at promoting oxidative addition in cross-coupling of aryl halides. With electron-rich, sterically demanding ligands, such as tri-tertbutylphosphine, coupling of aryl bromides could be achieved at room temperature. More imp
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Kurtz, Daniel A., Badrinath Dhakal, Lauren T. McDonald, Gary S. Nichol, and Greg A. N. Felton. "Inter-ligand intramolecular through-space anisotropic shielding in a series of manganese carbonyl phosphorous compounds." Dalton Transactions 48, no. 39 (2019): 14926–35. http://dx.doi.org/10.1039/c9dt03100f.

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Vorontsova, J. E., R. O. Cherezov, B. A. Kuzin, and O. B. Simonova. "Aryl-hydrocarbon receptor as a potential target for anticancer therapy." Biomeditsinskaya Khimiya 64, no. 5 (2018): 397–415. http://dx.doi.org/10.18097/pbmc20186405397.

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Aryl-hydrocarbon receptor (Aryl Hydrocarbon Receptor, AHR) is a ligand-dependent transcription factor, whose functions are related to xenobiotic detoxification, response to inflammation, and maintenance of tissue homeostasis. Recent investigations suggest that AHR also plays an important role in the processes of carcinogenesis. Increased expression of AHR is observed in several types of tumors and tumor cell lines. In addition, it turned out that the composition of pharmaceutical drugs used in oncotherapy includes some ligands AHR. These facts allow us to consider an aryl-hydrocarbon receptor
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Park, Robin, Shreya Madhavaram, and Jong Dae Ji. "The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function." Cells 9, no. 10 (2020): 2294. http://dx.doi.org/10.3390/cells9102294.

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Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in bone remodeling through altering the interplay between bone-forming osteoblasts and bone-resorbing osteoclasts. While effects of AhR signaling in osteoblasts are well understood, the role and mechanism of AhR signaling in regulating osteoclastogenesis is not widely understood. AhR, when binding with exogenous ligands (environmental pollutants such as polycylic aryl hydrocarbon (PAH), dioxins) or endogenous ligand indoxyl-sulfate (IS), has dual functions that are mediated by the nature of the
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Haddad, Nizar, Chris Senanayake, Hari Mangunuru, et al. "Enantioselective Arylation of Oxindoles Using Modified BI-DIME Ligands." Synthesis 50, no. 22 (2018): 4435–43. http://dx.doi.org/10.1055/s-0036-1591590.

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The Pd-catalyzed 3-arylation of 2-oxindoles with aryl bromides, chlorides and triflates is found to proceed using i-Pr-BI-DIME and Me2-BI-DIME ligands. The mono-arylation of 3-unsubstituted oxindoles is accomplished using a Pd2(dba)3/i-Pr-BI-DIME catalyst system, and gives good yields of 3-aryloxindoles from aryl bromides and chlorides. The arylation of 3-substituted oxindoles is also possible using this catalyst/ligand system. The asymmetric arylation of 3-substituted oxindoles is accomplished using Me2-BI-DIME to furnish oxindoles bearing a quaternary C-3 stereocenter in enantiomeric ratios
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Vinci, Daniele, Nelson Martins, Ourida Saidi, John Bacsa, Amadeu Brigas, and Jianliang Xiao. "Ferrocenyl phosphine–oxazaphospholidine oxide ligands for the Suzuki–Miyaura coupling of hindered aryl bromides and chlorides." Canadian Journal of Chemistry 87, no. 1 (2009): 171–75. http://dx.doi.org/10.1139/v08-113.

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A series of ferrocenyl oxazaphospholidine phosphines that differ electronically and sterically were investigated as ligands for the Suzuki–Miyaura cross-coupling reactions. One of these compounds, 1, was shown to be highly effective in the coupling reactions of bulky aryl bromides with boronic acids when combined with Pd(OAc)2, while another, 2, was capable of coupling aryl chlorides with boronic acids. However, these ligands were less effective in asymmetric induction.Key words: Suzuki–Miyaura coupling, ferrocenyl phosphines, aryl bromides, aryl chlorides, palladium.
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Dietrich, Cornelia. "Antioxidant Functions of the Aryl Hydrocarbon Receptor." Stem Cells International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/7943495.

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The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Binding of the ligand leads to dimerization of the AhR with aryl hydrocarbon receptor nuclear translocator (ARNT) and transcriptional activation of several xenobiotic phase I and phase II metabolizing enzymes. It is generally accepted that the toxic responses of polycyclic aromatic hy
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Puccetti, Matteo, Giuseppe Paolicelli, Vasileios Oikonomou, et al. "Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis." Mediators of Inflammation 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/1601486.

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Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a cytosolic, ligand-operated transcription factor that is involved in many biological processes, including development, cellular differentiation and proliferation, xenobiotic metabolism, and the immune response. Low-level activation of AhR by endogenous ligands is beneficial in the m
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Qiu, Canbin, Ken Yao, Xinghua Zhang та Hegui Gong. "Ni-catalyzed reductive coupling of α-halocarbonyl derivatives with vinyl bromides". Organic & Biomolecular Chemistry 14, № 48 (2016): 11332–35. http://dx.doi.org/10.1039/c6ob02269c.

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This work describes the vinylation of α-halo carbonyl compounds with vinyl bromides under Ni-catalyzed reductive coupling conditions. While aryl-conjugated vinyl bromides entail pyridine as the sole labile ligand, the alkyl-substituted vinyl bromides require both bipyridine and pyridine as the co-ligands.
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Berthelot-Bréhier, Anaïs, Armen Panossian, Françoise Colobert, and Frédéric R. Leroux. "Atroposelective synthesis of axially chiral P,S-ligands based on arynes." Organic Chemistry Frontiers 2, no. 6 (2015): 634–44. http://dx.doi.org/10.1039/c5qo00067j.

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Dissertations / Theses on the topic "Aryl ligands"

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Wall, Richard John. "Potency and species specificity of aryl hydrocarbon receptor ligands." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12798/.

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The aryl hydrocarbon receptor (AhR) binds a wide range of structurally diverse compounds such as halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls which are abundant in the environment. Activation of AhR leads to the regulation of a battery of xenobiotic enzymes including cytochrome P4501A1 (CYP1A1). The purely chlorinated compounds feature in the World Health Organisation’s (WHO) evaluation of dioxin-like compounds derived from a meta-analysis of previous potency data (toxic equivalency factors; TEFs), which is used to calculate the total toxic equivalence (TEQ). The first aim of thi
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Uiterweerd, Patrick Gerard Herman. "2,6-bis(dimethylamino)phenyl and 1-aza-2-phospha(V)allyl main group metal chemistry." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366076.

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Vuoti, S. (Sauli). "Syntheses and catalytic properties of palladium (II) complexes of various new aryl and aryl alkyl phosphane ligands." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514286483.

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Abstract Thirty three aryl and aryl alkyl phosphane ligands were prepared and characterized for catalytic purposes. The aryl groups in both types of ligands were modified with alkyl substituents (methyl, ethyl, isopropyl, cyclohexyl, phenyl) or hetero substituents (methoxy, N,N-dimethylaniline, thiomethyl). The alkyl groups directly attached to the phosphorous atom were ethyl, isopropyl or cyclohexyl. Mono- and in some cases also dinuclear palladium (II) complexes of the ligands were prepared and characterized. The syntheses of the palladium complexes are solvent-dependent and afford either mo
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Wahlström, Niklas. "Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-016-8/.

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Parks, Ashley Joan. "Modulation of the aryl hydrocarbon receptor by endogenous and exogenous ligands." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12830.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>This year it is estimated that over 34,000 American women will be diagnosed with triple-negative breast cancer (TNBC), an aggressive disease resistant to current targeted therapies. Consequently, development of
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Baker, Nicki A. "POLYCHLORINATED BIPHENYL LIGANDS OF THE ARYL HYDROCARBON RECEPTOR PROMOTE ADIPOCYTE-MEDIATED DIABETES." UKnowledge, 2013. http://uknowledge.uky.edu/nutrisci_etds/7.

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Numerous epidemiology studies suggest a correlation between exposures to polychlorinated biphenyls (PCBs) and the development and severity of type 2 diabetes (T2D); however, mechanisms remain largely unknown. Previous studies demonstrated that PCBs that are ligands of the aryl hydrocarbon receptor (AhR) promote the expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), that are linked to insulin resistance in adipocytes. To explore potential mechanisms linking PCB exposures to diabetes, we developed a mouse model of glucose and insulin intolerance induced by acute
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Savard, Didier. "The Versatile Chemistry of Aryl Substituted 1,2,4-triazole Ligands in Molecular Magnetism." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28677.

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The work presented in this thesis focuses on exploring the versatile chemistry of 4-aryl substituted 1,2,4-triazole derivatives. The ligands 4-(4'-nitrophenyl)-1,2,4-triazole (npt) and 4-(4'-carboxyphenyl)-1,2,4-triazole (Hcpt) were prepared following a modified known synthetic strategy. Reaction of either of these ligands with transition metal or lanthanide precursor salts resulted in two novel complexes, namely [FeII3(npt) 6(EtOH)4(H2O)2](ptol)6&middot;4(EtOH) (1) and [DyIII4(mu3-OH) 2(mu3-O)2(cpt)6(MeOH)6(H 2O)]2&middot;15,(MeOH) (5), and of five analogous compounds. In the case of 1, the s
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Zajdel, Pawel. "Novel Aryl-alkyl-piperazines with N-acylated amino acids as serotoninergic receptors ligands." Montpellier 1, 2006. http://www.theses.fr/2006MON13511.

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Ce travail présente des nouveaux composés ciblant les récepteurs sérotoninergiques. La première partie traite de la synthèse supposée d'une chimiothèque d'arylpiperazines. Plusieurs composés montrent une haute affinité pour 5-HT1A(K1=3-52nM). Des tests pharmacologiques pré-cliniques ont révélé des comportements de type agoniste complet ou partiel de 5-HT1A ou antagoniste 5-HT1A/5-HT2A. La synthèse supportée de 64 dérivés sulfonamide de la proline carboxamide est décrite, visant l'obtention d'antagonistes de 5-HT7. La dernière partie traite de la synthèse supportée sur lanternes BAL de dérivés
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Lücke, Sandra. "Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-851-8/.

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Grounds, Helen. "Investigations into the use of C-H activation for aryl-aryl bond formation : the synthesis of novel chiral ferrocene ligands for asymmetric catalysis." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478994.

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Books on the topic "Aryl ligands"

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Hestermann, Eli V. Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line. Massachusetts Institute of Technology, 2000.

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Book chapters on the topic "Aryl ligands"

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Romagnolo, Donato F., Stephanie C. Degner, and Ornella Selmin. "Aryl Hydrocarbon Receptor-Mediated Carcinogenesis and Modulation by Dietary Xenobiotic and Natural Ligands." In Bioactive Compounds and Cancer. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-627-6_32.

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Mehrotra, R. C., and B. S. Saraswat. "From Neutral Oxygen Donor Ligands [Ethers, Aldehydes, Ketones, Pyridine N-Oxides, Phosphine Oxides, Arsine Oxides, and Dialkyl(Aryl) Sulfoxides]." In Inorganic Reactions and Methods. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145203.ch8.

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Ponstingl, H., L. D. Barnes, C. Granzow, R. H. Himes, G. Maier, and G. Nasioulas. "Elucidating Ligand Binding Sites in Polypeptides by Photoaffinity Labeling with Aryl Azides." In Methods in Protein Sequence Analysis. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-5678-2_16.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_656.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_657.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_658.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_659.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_660.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_661.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(III) complex with tetradentate aryl substituted Schiff-base ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_662.

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Conference papers on the topic "Aryl ligands"

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Kottmann, R. Matthew, Thomas Thatcher, Katie Smolnycki, Elizabeth Lyda, Rick P. Phipps, and Patricia Sime. "Aryl Hydrocarbon Receptor Ligands Inhibit TGFb Induced Myofibroblast Differentiation." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2713.

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Kottmann, Robert M., Thomas H. Thatcher, Elizabeth Lyda, Amali Epa, Richard P. Phipps, and Patricia J. Sime. "Aryl Hydrocarbon Receptor Ligands Inhibit TGF² Induced Myofibroblast Differentiation." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1930.

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Romagnolo, Donato F., Ornella I. Selmin, and Andreas J. Papoutsis. "Abstract 1115: Epigenetic regulation of BRCA-1 by xenobiotic and dietary ligands of the aryl hydrocarbon receptor." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1115.

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Tsai, Ming-Ju, Po-Lin Kuo, Ya-Ling Hsu, Chi-Tun Lien, and Ming-Shyan Huang. "The Aryl Hydrocarbon Receptor (AhR) Ligands Increase Expression Of Matrix Metalloproteinase-1 And Interleukin-1² In Airway Epithelial Cells." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4663.

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Krinochkin, Alexey P., Dmitry S. Kopchuk, Sougata Santra, Grigory V. Zyryanov, Vladimir L. Rusinov, and Oleg N. Chupakhin. "Preparation of ligands for lanthanide cations based on 5-aryl-2,2′-bipyridine-6′-carboxylic acids with an extended conjugation system." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087364.

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Brantley, Eileen, Nicole Mavingire, Jonathan Wooten, and Petreena Campbell. "Abstract 1304: Aryl hydrocarbon receptor ligands 5F 203 and 3,3'-Diindolylmethane disrupt mammospheres derived from MCF-7 cells and induce tumor suppressor miR125b-2 expression." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1304.

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Brantley, Eileen, Nicole Mavingire, Jonathan Wooten, and Petreena Campbell. "Abstract 1304: Aryl hydrocarbon receptor ligands 5F 203 and 3,3'-Diindolylmethane disrupt mammospheres derived from MCF-7 cells and induce tumor suppressor miR125b-2 expression." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1304.

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Flaherty, Patrick T., Jane C. Cavanaugh, Mohit Gupta, et al. "Abstract 1963: Analysis of aryl substitution and intramolecular ligand H-bonding in selective inhibitors of the MEK5/ERK5 cascade." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1963.

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Reports on the topic "Aryl ligands"

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Johnston, Randy F. Electron Density Modulation of Catalytic Metal Centers by Substituted Aryl-Isocyanide Ligands. Defense Technical Information Center, 1989. http://dx.doi.org/10.21236/ada212875.

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