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Dissertations / Theses on the topic 'Aryl ligands'

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Published: 4 June 2021

Last updated: 5 February 2022

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1

Wall, Richard John. "Potency and species specificity of aryl hydrocarbon receptor ligands." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12798/.

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The aryl hydrocarbon receptor (AhR) binds a wide range of structurally diverse compounds such as halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls which are abundant in the environment. Activation of AhR leads to the regulation of a battery of xenobiotic enzymes including cytochrome P4501A1 (CYP1A1). The purely chlorinated compounds feature in the World Health Organisation’s (WHO) evaluation of dioxin-like compounds derived from a meta-analysis of previous potency data (toxic equivalency factors; TEFs), which is used to calculate the total toxic equivalence (TEQ). The first aim of thi

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2

Uiterweerd, Patrick Gerard Herman. "2,6-bis(dimethylamino)phenyl and 1-aza-2-phospha(V)allyl main group metal chemistry." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366076.

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3

Vuoti, S. (Sauli). "Syntheses and catalytic properties of palladium (II) complexes of various new aryl and aryl alkyl phosphane ligands." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514286483.

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Abstract Thirty three aryl and aryl alkyl phosphane ligands were prepared and characterized for catalytic purposes. The aryl groups in both types of ligands were modified with alkyl substituents (methyl, ethyl, isopropyl, cyclohexyl, phenyl) or hetero substituents (methoxy, N,N-dimethylaniline, thiomethyl). The alkyl groups directly attached to the phosphorous atom were ethyl, isopropyl or cyclohexyl. Mono- and in some cases also dinuclear palladium (II) complexes of the ligands were prepared and characterized. The syntheses of the palladium complexes are solvent-dependent and afford either mo

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4

Wahlström, Niklas. "Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-016-8/.

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5

Parks, Ashley Joan. "Modulation of the aryl hydrocarbon receptor by endogenous and exogenous ligands." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12830.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>This year it is estimated that over 34,000 American women will be diagnosed with triple-negative breast cancer (TNBC), an aggressive disease resistant to current targeted therapies. Consequently, development of

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6

Baker, Nicki A. "POLYCHLORINATED BIPHENYL LIGANDS OF THE ARYL HYDROCARBON RECEPTOR PROMOTE ADIPOCYTE-MEDIATED DIABETES." UKnowledge, 2013. http://uknowledge.uky.edu/nutrisci_etds/7.

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Numerous epidemiology studies suggest a correlation between exposures to polychlorinated biphenyls (PCBs) and the development and severity of type 2 diabetes (T2D); however, mechanisms remain largely unknown. Previous studies demonstrated that PCBs that are ligands of the aryl hydrocarbon receptor (AhR) promote the expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), that are linked to insulin resistance in adipocytes. To explore potential mechanisms linking PCB exposures to diabetes, we developed a mouse model of glucose and insulin intolerance induced by acute

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7

Savard, Didier. "The Versatile Chemistry of Aryl Substituted 1,2,4-triazole Ligands in Molecular Magnetism." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28677.

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The work presented in this thesis focuses on exploring the versatile chemistry of 4-aryl substituted 1,2,4-triazole derivatives. The ligands 4-(4'-nitrophenyl)-1,2,4-triazole (npt) and 4-(4'-carboxyphenyl)-1,2,4-triazole (Hcpt) were prepared following a modified known synthetic strategy. Reaction of either of these ligands with transition metal or lanthanide precursor salts resulted in two novel complexes, namely [FeII3(npt) 6(EtOH)4(H2O)2](ptol)6·4(EtOH) (1) and [DyIII4(mu3-OH) 2(mu3-O)2(cpt)6(MeOH)6(H 2O)]2·15,(MeOH) (5), and of five analogous compounds. In the case of 1, the s

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8

Zajdel, Pawel. "Novel Aryl-alkyl-piperazines with N-acylated amino acids as serotoninergic receptors ligands." Montpellier 1, 2006. http://www.theses.fr/2006MON13511.

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Ce travail présente des nouveaux composés ciblant les récepteurs sérotoninergiques. La première partie traite de la synthèse supposée d'une chimiothèque d'arylpiperazines. Plusieurs composés montrent une haute affinité pour 5-HT1A(K1=3-52nM). Des tests pharmacologiques pré-cliniques ont révélé des comportements de type agoniste complet ou partiel de 5-HT1A ou antagoniste 5-HT1A/5-HT2A. La synthèse supportée de 64 dérivés sulfonamide de la proline carboxamide est décrite, visant l'obtention d'antagonistes de 5-HT7. La dernière partie traite de la synthèse supportée sur lanternes BAL de dérivés

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9

Lücke, Sandra. "Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-851-8/.

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10

Grounds, Helen. "Investigations into the use of C-H activation for aryl-aryl bond formation : the synthesis of novel chiral ferrocene ligands for asymmetric catalysis." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478994.

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11

Tabey, Alexis. "Synthèse de nouveaux complexes aryl-palladium et aryl-or pour le marquage par du monoxyde de carbone de composés bioconjugués supportés et pour des réactions de couplages." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0025/document.

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L’essor de la chimie organométallique a permis de développer de nouvelles possibilités dans le domaine du diagnostic médical, en particulier pour la tomographie à émission de positrons (TEP). Ainsi, de nouvelles méthodologies ont été développées pour permettre la synthèse de bio-traceurs avec le marquage au 11C comme étape finale. Dans ce contexte, notre équipe a récemment développé une nouvelle méthodologie pour marquer une large variété de substrats dans des conditions standards de carbonylation et ces travaux de thèse présentent une nouvelle stratégie de synthèse impliquant la préformation

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12

Ng, Fei-yeung, and 吳飛洋. "Structure and properties of self-assembled coordination compounds: homoleptic d10-metal aryl/alkylacetylides, ruthenium n-heterocyclesand picolinates." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37878566.

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13

Lo, Chun Yu. "Synthesis and characterization of group 4 complexes and olefin polymerization catalysts supported by chelating v-aryl ligands /." access full-text access abstract and table of contents, 2009. http://libweb.cityu.edu.hk/cgi-bin/ezdb/thesis.pl?mphil-bch-b23750947f.pdf.

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Thesis (M.Phil.)--City University of Hong Kong, 2009.<br>"Submitted to Department of Biology and Chemistry in partial fulfillment of the requirements for the degree of Master of Philosophy." Includes bibliographical references.

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14

Ovesen, Jerald Lee. "Aryl Hydrocarbon Receptor Ligands of Widely Different Toxic Equivalency Factors Induce Similar Histone Marks in Target Gene Chromatin." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291408173.

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15

Barf, Tjeerd Andries. "The medicinal chemistry of aryl triflates as applied to 5-HT1A and 5-HT1D receptor ligands /." [S.l. : [Groningen] : s.n.] ; [University Library Groningen] [Host], 1996. http://irs.ub.rug.nl/ppn/152303871.

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16

Dyke, Alan. "Novel Câ‚‚-symmetric N,N-donor ligands and the anionic thia-Fries rearrangement of aryl triflates." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404435.

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17

Ng, Fei-yeung. "Structure and properties of self-assembled coordination compounds : homoleptic d10-metal aryl/alkylacetylides, ruthenium n-heterocycles and picolinates." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36587126.

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18

Houte, Henri. "Contribution à l'aménagement fonctionnel des tropolones, synthèse de 5-aryl-3,7-dihydroxytropolones et de tropolones O-alkylées : inhibiteurs potentiels de phosphatases." Rouen, 2002. http://www.theses.fr/2002ROUES018.

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Les propriétés chélatantes des tropolones vis-à-vis des ions métalliques en font des inhibiteurs potentiels de métalloenzymes ; c'est ainsi qu'il a été montré recemment que la 3,7-dihydroxytropolone pouvait mimer un groupement phosphate dans le site actif de l'inositol monophosphatase. L'éther tropolonique se positionne donc comme un analogue de l'inositol monophosphate dans lequel l'unité dihydroxytropolonique se comporterait comme un analogue organique de la fonction phosphate. Afin de conforter cette assertion et d'affiner la relation structure-activité, ce travail avait pour objectif ultim

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19

Zhang, Ye. "Development of amide-derived P,O-ligands for Suzuki cross-coupling of aryl chlorides and the asymmetric version /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202005%20ZHANG.

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20

Milton, Edward J. "Pd catalysed C-C & C-O bond formation using bis-(dialkyl/diarylphosphino)ferrocene ligands." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/1022.

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A brief introduction explaining phosphine ligand properties, Pd catalysed cross-coupling reactions; the importance of the steps involved in the catalytic cycle (oxidative addition, transmetalation & reductive elimination), mechanistic studies and a comparison of various reactions will give an overview of important cross-coupling reactions and their limitations. The development of a “super-concentrated” (5M) Pd catalysed Kumada type coupling reaction has been developed for coupling a range of aryl bromide and chloride substrates with the Grignard reagents ((p-CF₃-C₆H₄)MgBr)) and PhMgBr in methy

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21

Abu-Rizq, Hana'A. "The effects of exogenous and endogenous ligands of the aryl hydrocarbon receptor on the activation of autoimmune diabetes." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-effects-of-exogenous-and-endogenous-ligands-of-the-aryl-hydrocarbon-receptor-on-the-activation-of-autoimmune-diabetes(485ca722-0673-4009-8ba3-faaf26434013).html.

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The aryl-hydrocarbon receptor (AhR) is an important receptor found in immune cells. It functions as a detector of environmental toxins, naturally occurring dietary products, and endogenous tryptophan derivatives for induction of gene transcription responses. Previous reports have implicated stimulation of AhR by various ligands in promoting T cell activation or regulatory function, with effects on autoimmune disease models. Also, effects of Ah toxins or natural products on increasing or suppressing inflammation and innate cytokine production, and dendritic cell function, have been reported. Di

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22

Benedict, Valerie. "The Effect of Endogenous Ligands of the Aryl Hydrocarbon Receptor on Antibody Expression in a Human B-Cell Model." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622126480271197.

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23

Chang, Xiaoqing. "Role of the aryl hydrocarbon receptor in the regulation of cell cycle progression in the absense of xenobiotic ligands." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1179423103.

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24

Chang, Xiaoqing. "Role of the Aryl Hydrocarbon Receptor in the Regulation of Cell Cycle Progression in the Absence of Xenobiotic Ligands." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179423103.

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25

Zhu, Chongwei. "Advances in the coordination chemistry of nitroaromatic phosphines : synthesis and supramolecular chemistry of alkyl/aryl carbo-benzene derivatives." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30281/document.

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Le manuscrit est divisé en six chapitres et deux parties indépendantes, la première étant consacrée à l'étude de l'effet de substituants nitro sur des ligands phosphines aromatiques (L). Une série de (N-phényl-benzimidazol-1-yl)diphénylphosphines substituées par 1 à 3 groupes nitro à différentes positions des noyaux N-phényle et benzimidazolyle, a été synthétisée, et comparée au parent non nitré et à l'homologue N-méthyl-benzimidazolium cationique. Dans les complexes trans-L2RhICl(CO) correspondants, des variations faibles mais systématiques de la fréquence d'élongation C=O IR et du déplacemen

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26

Buron, Christophe. "Les Diaminocarbènes : de nouveaux ligands pour les métaux de transition, les phosphinocarbènes : synthèse des premiers alkyl-et-aryl-carbènes stables." Toulouse 3, 2000. http://www.theses.fr/2000TOU30207.

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27

Mtongana, Sibusiso. "A multinuclear magnetic resonance spectroscopy study of E/Z configurational isomers of unsymmetrical N-alkyl-N-alkyl(aryl)-N'-acylthioureas of platinum(II) complexes." Thesis, Stellenbosch : Stellenbosch University, 2006. http://hdl.handle.net/10019.1/21893.

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Dissertation (PhD)--University of Stellenbosch, 2006.<br>ENGLISH ABSTRACT: The partial double bond character of the carbon-nitrogen bond of the (S)C-NRR’ moiety results in unsymmetrical dialkyl-substituted N-alkyl-N-alkyl(aryl)-N’-acylthioureas, R”C(O)NHC(S)NRR’ (HL) displaying E,Z configurational isomerism in solution. The isomerism manifests itself by the duplication of resonances of the N-alkyl groups in the 1H and 13C NMR spectra. In one class of these ligands where R and R’ groups are non-equivalent alkyl groups the isomerism is easily observable at 298 K in chloroform. In the other c

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28

Pialat, Amélie. "Formation de liaisons C-N et C-O par catalyse de coordination ou par oxydation à l'iode hypervalent." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20204/document.

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La fonctionnalisation directe de liaisons C-H offre une alternative plus économe en atomes et étapes que les traditionnelles méthodes de synthèse basées sur la transformation de molécules pré fonctionnalisées. Ainsi, les réactions d'amination intermoléculaire de liaisons C(sp3)-H avec des nitrènoïdes sont généralement effectuées avec des rendements et des régiosélectivités modérés et utilisent pour cela des catalyseurs coûteux. Dans ce contexte, nous avons créé de nouveaux systèmes bifonctionnels pour la formation de liaisons C-N aliphatiques catalysée par le cuivre et l'argent. Ces systèmes s

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29

Cui, Chunming. "Aluminum (I, II, III) Compounds with Multidentate Ligands: Syntheses, Reactivity, and Structures." Doctoral thesis, [S.l. : s.n.], 2001. http://webdoc.sub.gwdg.de/diss/2001/cui/cui.pdf.

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30

Al-Deeb, Omar A. A. "On the investigation of the synthesis, stereochemistry and structure-activity relationship of opioid ligands related to 4-aryl-1-methylpiperidines and phencyclidine." Thesis, University of Bath, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760592.

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31

Adongo, John. "Modification of Surfaces with Carboxymethylthio and Piperazinyl Chelating Ligands for Heavy Metal Trapping Applications." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19697.

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Die zwei Chelatbildner für Schwermetallionen, Carboxymethylthio- (CMT) und Piperazinyl- (PPz), wurden erfolgreich über die direkte kathodische Elektroreduktion ihres Aryl diazoniumsalzes auf Wasserstoff–terminiertes Silizium (Si-H)- und auf Gold (Au)-Substratoberflächen aus den Derivaten: 4-(Carboxymethylthio)benzenediazoniumsalz [4-CMTBD]+BF4- und 4-(Piperazinyl)benzenediazoniumsalz [4-PPzBD]+BF4- abgeschieden. Die elektrochemische Anbindung wurde unter Verwendung von zyklischer Voltammetrie (CV) und chronoamperometrie (CA) Techniken durchgeführt. Die IRSE-Spektren bestätigten die Anwesenheit

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32

Geyer, Roland [Verfasser], and Armin [Akademischer Betreuer] Buschauer. "Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships / Roland Geyer. Betreuer: Armin Buschauer." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1023276240/34.

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33

Larsson, Malin. "Computational methods for analyzing dioxin-like compounds and identifying potential aryl hydrocarbon receptor ligands : multivariate studies based on human and rodent in vitro data." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-139487.

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Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are omnipresent and persistent environmental pollutants. In particular, 29 congeners are of special concern, and these are usually referred to as dioxin-like compounds (DLCs). In the European Union, the risks associated with DLCs in food products are estimated by a weighted sum of the DLCs’ concentrations. These weights, also called toxic equivalency factors (TEFs), compare the DLCs’ potencies to the most toxic congener, 2,3,7,8-tetrachloro-dibenzo-p-dioxin (2378- TCDD). The toxicological effects of

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34

Neuville, Luc. "S nar inter- et intramoleculaire : approche vers la synthese totale de la teicoplanine synthese combinatoire de bibliotheques aryl-amines synthese de nouveaux ligands tri- et tetradentes." Paris 11, 1999. http://www.theses.fr/1999PA112246.

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Dans la premiere partie de ce travail, nous nous sommes interesses a la synthese de la teicoplanine, antibiotique, utilise dans le traitement d'infections bacteriennes. Par l'utilisation de deux reactions de substitution nucleophile aromatique (s nar) intamoleculaires sequentielles, un analogue bicyclique a 16 + 14 chainons de la partie est de la teicoplanine, comportant deux liaison ether-biaryl, a ete obtenu. Comme modele de la partie ouest de la teicoplanine, nous avons choisi de realiser un bicycle a 16 + 12 chainons, comprenant une liaison ether-biaryl (cycle a 16) et une liaison biaryliq

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35

Jiang, Tao. "Characterisation of recombinant aryl hydrocarbon receptor ligand binding domain." Thesis, University of Nottingham, 2004. http://eprints.nottingham.ac.uk/10401/.

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Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which mediates the toxicity of dioxin and related compounds, and has an important role in development. However, a structural basis for ligand binding to the AhR remains unclear and the study was hindered by the low abundance and inherited instability of the AhR. Based on a previously defined minimal ligand-binding domain (LBD, residues 230-421), in the present study a series of truncated LBD constructs were created and expressed in insect cells (Sf9) using a baculovirus expression system. An antibody was produced to an

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36

Peace, Richard John. "Bulky ligand systems containing pi-acidic aryl and carboranyl groups." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5388/.

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This thesis describes studies into the synthesis and coordination chemistry of ligands containing bulky π-acidic groups. Both π-acidic aryl and carboranyl groups have been investigated. Chapter One highlights electronic and structural aspects of ligands investigated and computational techniques employed. Chapter Two describes the synthesis of aromatic systems bearing nitrogen substituents and trifluoromethyl groups, with a view to their use in the synthesis of new ligands. The π -interaction between the nitrogen substituent and aromatic ring has been investigated and is found to vary considera

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37

Helaly, Ahmed. "Expression of the Caenorhabditis elegans aryl hydrocarbon receptor ligand binding domain." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/11929/.

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The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which mediates the potent toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. AhR is regulated by the ligand-binding domain (LBD) of the AhR, and so determining how the binding of ligand activates AhR is of considerable interest. However, there are no structural data on mammalian AhR LBDs, and expression of the mouse AhR LBD in E. coli yields insoluble protein. Expression in more complex systems, such as insect cells (Spodoptera frugiperda), yields soluble AhR LBD, but only ~10% of th

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38

Hammond, Roger C. "Kinetic studies directed towards the improvement of Sandmeyer reactions." Thesis, University of York, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296294.

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39

Martínez, Viviente Eloísa. "Síntesis, Caracterización y Reactividad de Complejos de Pd(II) con Ligandos Arilo Sustituidos en orto. Aplicaciones en Síntesis Orgánica." Doctoral thesis, Universidad de Murcia, 2001. http://hdl.handle.net/10803/108690.

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Se describe la síntesis de una serie de complejos de Pd(II) con ligandos arilo que contienen en orto los grupos vinilo (CH=CH2), formilo (CHO), acetilo (C(O)Me) y nitrilo (CN), sin sustituyentes adicionales, y se estudia su reactividad frente a moléculas insaturadas: alquinos, isocianuros y monóxido de carbono. De esta forma se obtienen compuestos orgánicos de interés, difíciles de preparar por otros métodos. La tesis contiene un capitulo dedicado a la investigación mediante Resonancia Magnética Nuclear del enlace C-Pd en estos complejos. El último capítulo describe la síntesis del primer lig

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40

Cheaib, Khaled. "Synthesis, characterization and photochemical properties of 3d transition metal supported by aroyl-hydrazone ligands." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAF062/document.

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Ce travail de thèse explorait certains aspects de la chimie de coordination de complexes moléculaires à bases de métaux 3d (Fe, Cu, Mn et Ni) supportés par des ligands azotés de type aroyle-hydrazone. Le travail de cette thèse était plus particulièrement centré sur le développement des nouveaux ligands et la photo chimie des complexes ferriques, afin d’élucider en particulier les mécanismes de la photo réduction qui valorise un brevet du laboratoire sur la production et le stockage d’énergie solaire via la photo réduction d’ions ferriques. Les complexes mis en jeu dans le processus ont été tot

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41

Mei, Han. "Homology modeling of aryl hydrocarbon receptor and its ligand-binding properties investigated by molecular dynamics simulation." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1289.

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42

Harrelson, John P. "A comparative study of cytochromes P450 2E1 and 2A6 : substrate dynamics, multiple ligand binding, and adduct formatioin by N-acetyl-m-aminophenol /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8166.

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43

Mtongana, Sibusiso. "A multinuclear (1H, 13C, 31P and 195Pt) magnetic resonance spectroscopy study of mixed ligand platinum(II) complexes with new N,N-dialkyl-N'-acyl(aroyl)thioureas as ligands." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52649.

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44

Ponnakanti, Himaja. "Soluble and Functional Overexpression of the Ligand Binding Domain of Mouse Aryl Hydrocarbon Receptor in E.Coli." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/260.

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The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor whose toxicity and carcinogenesis is mediated through various polyaromatic hydrocarbons and other environmental pollutants. The role of AhR in carcinogenesis is an area of concern due its altered levels in various tumors. AhR binds structurally diverse ligands and may elicit different responses upon ligand binding. The crystal structure of mouse AhR PAS-A domain was already obtained due to the robustness of mouse AhR in comparison to human. There is a possibility of overexpressing mouse AhR ligand binding

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45

Sudarga, Tjakraatmadja Airlangga Arya Janitra [Verfasser]. "Copper complexes with bpa- and phen-based ligands as artificial nucleases / Airlangga Arya Janitra Sudarga Tjakraatmadja." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1103486632/34.

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46

Odabas, Serhat. "Asymmetric Synthesis Of N-aryl Substituted Chiral 1,4-amino Alcohol Derivatives And Applications In Various Asymmetric Transformation Reactions." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608489/index.pdf.

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The asymmetric synthesis of N-aryl substituted chiral 1,4-aminoalcohols and their applications in asymmetric borane reduction and enantioselective diethylzinc addition to benzaldehyde reactions were performed starting from meso anhydride 51 that is the cycloadduct of cyclopentadiene and maleic anhydride. The desymmetrization of meso-anhydride 51 was achieved by using quinine or quinidine with very high enantiomeric excess value (up to 98% ee) and with high chemicalb yield. The quinine-mediated desymmetrization of meso-anhydride 51 with methanol gave (2S,3R)-(-)-cis-monoester 52. The hemiester

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47

Seaman, Lani Anne. "Investigation of the 6d and 5f Orbital Contributions in Actinide Complexes Containing Amide, Ketimide, Aryl, and Alkyl Metal-Ligand Bonds." University of California, Santa Barbara, 2013.

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48

Klopper, Reynhardt. "An investigation into the complex formation and potential solvent extraction of Os(IV/III) with N, N - dialkyl - N′- acyl(aroyl)thioureas." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2762.

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Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2006.<br>This study involved the preliminary investigation into the potential liquid-liquid extraction of Os(IV/III) from hydrochloric acid solutions with ligands of type N,N-dialkyl-N′-acyl(aroyl)thioureas (HL), and ultimate selective pre-concentration and separation of Os(IV/III) from the other platinum group metals. Investigations have also been focused towards understanding the speciation of Os(IV) in hydrochloric acid medium. A series of osmium complexes with ligands of type HL have been synthesised and characteris

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49

Amamou, Asma. "Le récepteur minéralocorticoide : une cible potentielle dans la fibrose intestinale ? Mineralocorticoid receptor antagonisl improves inflammation and fibrosis in chronic DSS colitis mouse model Neutrophil gelatinas-associated lipocalin (NGAL) is a mineralocorticoid receptor target involved in intestinal inflammation and fibrosis Inflammatory bowel diseases and food additives : to add fuel on the flames Dietary salt activates intestinal fibroblasts, thereby contributing to exacerbation of intestinal fibrosis Dietary aryl hydrocarbon receptor ligands have no anti-fibrotic properties in transforming growth factor-β1-stimulated human colonic fibroblasts Effet d'un régime riche en sel sur la fibrose intestinale dans un modèle murin de colite chronique Etude de l'interaction entre des dérivés du tryptophane et le récepteur aryl hydrocarbone dans un modèle in vitro de fibrose intestinale". Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR079.

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Les maladies inflammatoires chroniques de l’intestin (MICI) se développent chez des individus génétiquement prédisposés sous l’influence de facteurs environnementaux. La fibrose intestinale est une complication fréquente de ces MICI sans traitement spécifique, qui se caractérise par une accumulation de matrice extracellulaire synthétisée par les cellules mésenchymateuses. Le récepteur minéralocorticoïde (RM) est l’effecteur terminal du système hormonal rénineangiotensine-aldostérone (SRAA). Le RM et l’ensemble des composants du SRAA sont exprimés dans le tractus gastro-intestinal et leur expre

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50

Karim, Abdallah. "Réductions asymétriques d'oléfines et de cétones catalysées par des complexes du rhodium modifiés par de nouveaux ligands phosphorés aryle et alkyle AMPP Chiraux." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37598643x.

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