Relevant bibliographies by topics / Asymmetric synthesis. Lactones

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  2. Dissertations / Theses
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Academic literature on the topic 'Asymmetric synthesis. Lactones'

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Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Asymmetric synthesis. Lactones"

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Mondon, M., and J. Gesson. "Asymmetric Synthesis of Styryl-Lactones." Current Organic Synthesis 3, no. 1 (February 1, 2006): 41–75. http://dx.doi.org/10.2174/157017906775473966.

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Shimotori, Yasutaka, Kazuki Sekine, and Tetsuo Miyakoshi. "Asymmetric synthesis ofδ-lactones with lipase catalyst." Flavour and Fragrance Journal 22, no. 6 (2007): 531–39. http://dx.doi.org/10.1002/ffj.1836.

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Wong, Leon S. M., Kathleen A. Turner, Jonathan M. White, Andrew B. Holmes, and John H. Ryan. "Asymmetric Synthesis of a Hydroxylated Nine-membered Lactone from Tartaric Acid using the Claisen Rearrangement." Australian Journal of Chemistry 63, no. 3 (2010): 529. http://dx.doi.org/10.1071/ch09637.

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The synthesis of a hydroxylated vinyl-appended lactone, in five synthetic steps from tartaric acid, is reported. The C2-symmetrical bis-vinyl diol 12 was converted into the ketene acetal 14 via methylenation of the cyclic carbonate 13 or thermal elimination of benzeneselenenic acid from the selenoxide 17. In both cases, the in situ generated ketene acetal 14 underwent spontaneous Claisen rearrangement to give the nine-membered lactone (+)-15. Lactones of this type are potentially advanced precursors to simplified eleutherobin analogues or other medium-ring lactone natural products.
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Li, Yanjun, and Taeko Izumi. "Asymmetric Synthesis of Chiral δ-lactones using BINAP-ruthenium(II) Complexes Hydrogenation Catalysts." Journal of Chemical Research 2002, no. 11 (November 2002): 567–69. http://dx.doi.org/10.3184/030823402103170790.

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Asymmetric hydrogenation of keto-acids was accomplished by catalytic amounts of BINAP-ruthenium complexes to afford the corresponding δ-lactones in high yields. The optical purity of the synthesised δ-lactones was determined by chiralcel (OD) in the 9–56% range.
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Yang, Jiaxin, Xiuxiu Li, Cai You, Shuailong Li, Yu-Qing Guan, Hui Lv, and Xumu Zhang. "Rhodium-catalyzed asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds." Organic & Biomolecular Chemistry 18, no. 5 (2020): 856–59. http://dx.doi.org/10.1039/c9ob02536g.

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Ray Choudhury, Abhijnan, and Santanu Mukherjee. "Deconjugated butenolide: a versatile building block for asymmetric catalysis." Chemical Society Reviews 49, no. 18 (2020): 6755–88. http://dx.doi.org/10.1039/c9cs00346k.

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Deconjugated butenolides have emerged as a popular synthon for the enantioselective synthesis of γ-lactones. This review provides a comprehensive overview on the catalytic asymmetric reactions of deconjugated butenolides reported till date.
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Nagao, Yoshimitsu, Toshiaki Tohjo, Masahito Ochiai, and Motoo Shiro. "Expeditious Asymmetric Synthesis of Optically Pure δ-Lactones Bearing Consecutive Three Asymmetric Centers." Chemistry Letters 21, no. 2 (February 1992): 335–38. http://dx.doi.org/10.1246/cl.1992.335.

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Marco, J. Alberto, and Miguel Carda. "Stereoselective Synthesis of Five Biologically Active, Naturally Occurring Medium and Large Ring Lactones." Natural Product Communications 6, no. 4 (April 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600411.

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Stereoselective syntheses of five naturally occurring, pharmacologically active medium and large ring lactones are described. Key synthetic methods used were, depending on the cases, olefin metatheses, asymmetric allylations and C-glycosidations.
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Gaikwad, Ravindra D., Monica D. Rane, and Sujata V. Bhat. "Asymmetric synthesis of (6R)-4-hydroxy-6-substituted-δ-lactones." Tetrahedron: Asymmetry 28, no. 1 (January 2017): 181–85. http://dx.doi.org/10.1016/j.tetasy.2016.12.006.

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Peed, Jennifer, Ignacio Periñán Domínguez, Iwan R. Davies, Matt Cheeseman, James E. Taylor, Gabriele Kociok-Köhn, and Steven D. Bull. "Asymmetric Synthesis of Chiral δ-Lactones Containing Multiple Contiguous Stereocenters." Organic Letters 13, no. 14 (July 15, 2011): 3592–95. http://dx.doi.org/10.1021/ol2012023.

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Dissertations / Theses on the topic "Asymmetric synthesis. Lactones"

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Wright, Edward Andrew. "π-Allyltricarbonyliron lactones in asymmetric synthesis." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621938.

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Edwards, M. I. "Asymmetric synthesis of lignan lactones from meso compounds." Thesis, Swansea University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636768.

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The purpose of this research was to form (2S, 3R)-2,3bis(3,4-dimethoxybenzyl) butyrolactone. A brief review of the main classes of lignans, their biosynthesis, biological activity and clinical utility is given in the first chapter. The main chemical synthesis routes to such compounds are also provided covering the six most commonly used routes including the Stobbe condensation. An overview of the use of meso compounds for the production of chiral synthons and use of the 'meso trick' to enhance yields during chiral induction to meso substrates are discussed in chapter two. Construction of the basic C18 lignan skeleton in chapter three is achieved via a double Stobbe condensation with preferential formation of the E-isomer at each stage. In the first step the Stobbe product is reduced to give the maleic anhydride. This resisted further reduction but reduction of the dimethyl maleate successfully gave the meso succinic anhydride with no d/l isomer formation. The formation of the target compound is described in chapter four. Reaction of the meso substrate with (+)-α-methylbenzylamine proceeded with chiral induction in 81% d.e. The use of chiral alcohols including 1-methol, 1-α phenyl ethylalcohol and S-(+)-methyl mandelate has also been examined showing widely varying diastereoselectivities. Conversion of (2S, 3R, αR)-N-(α-phenylethyl)- 2,3-bis(3,4-dimethoxybenzyl)butanedioic acid monoamide to the target dibenzyl butyrolactone has been readily achieved by reduction to the corresponding alcohol prior to lactonisation. Racemisation of (2S, 3R)-2,3-bis(3,4-dimethoxybenzyl) butyrolactone under basic conditions and comparison of the optical rotation values obtained with those in the literature allowed the absolute stereochemistry to be assigned. The attempted formation of picrostegane type lignans by non phenolic oxidative coupling is also described.
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Harsh, Philip R. "Applications of asymmetric allylation reactions towards natural product synthesis." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6029.

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Thesis (M.S.)--West Virginia University, 2008.
Title from document title page. Document formatted into pages; contains vi, 78 p. : ill. Includes abstract. Includes bibliographical references (p. 37-38).
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Oh, Seongho. "Optimization and extensions of the nucleophile catalyzed aldol-lactonization (NCAL) process for bicyclic beta-lactone synthesis: applications to piperidine, pyrrolidine, and gamma-lactam-fused beta-lactones." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3961.

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The intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process was optimized successfully. A variety of C9-acylated cinchona alkaloids were synthesized and used for NCAL reactions with non-activated aldehydes. New pyridinium salts, derivatives of Mukaiyama’s reagent, led to marked improvements in efficiency for the catalytic, asymmetric NCAL process while maintaining high enantioselectivity. Larger scale versions of the catalytic, asymmetric NCAL reaction were also developed allowing practical access to chiral bicyclic b-lactones. As an extension of the intramolecular NCAL process, pyrrolidine and piperidine fused blactones were synthesized. Simple g-lactam fused b-lactones were synthesized as a model study for omuralide, salinosporamide A, and derivative synthesis. Synthesis of asubstituted aldehyde acids was extensively studied but steric effects from both acid and amine moieties led to great difficulties in this approach.
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Soltani, Omid. "Photochemical preparations of salicylate/resorcylate esters/amides asymmetric synthesis of SCH 351448 /." Access to abstract only; dissertation is embargoed until after 5/16/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=168.

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Rabiller, Christine. "Nouvelles voies de synthèse de lactones bioactives." Nancy 1, 1994. http://www.theses.fr/1994NAN10339.

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La synthèse enantiospécifique de lactones bioactives, inhibitrices d'une part de l'hmgcoa réductase, et d'autre part des lipases pancréatiques a été entreprise. Dans une première partie, l'accès facile et rapide à des composés de structure didesoxy-2-4-hexopyranose, chiron clé pour la synthèse d'inhibiteurs de la biosynthèse du cholestérol, a été réalisé par transformation stéréospécifique du 1,6-anhydro-beta-d-glucopyranose obtenu par pyrolyse dans de bonnes conditions qui ont été mises au point dans ce travail. Dans la deuxième partie, l'application des méthodes de création de liaison carbone-carbone en c-2 et en c-6 sur un dérivé du glucose, a permis d'ouvrir deux nouvelles voies pour la préparation d'intermédiaires clés de la synthèse de la valilactone, le tetrahydrolipstatine et la tetrahydroexterastine, composes d'intérêt pharmacologique pour le traitement de l'obésité
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Olabisi, Ayodele O. Wimalasena Kandatege. "The chemistry of L-ascorbic acid derivatives in the asymmetric synthesis of C2- and C3-substituted aldono-gamma-lactones." Diss., Access through your commercial service, 2005. http://il.proquest.com/products_umi/dissertations/.

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Thesis (Ph.D.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry.
"August 2005." Title from PDF title page (viewed on February 6, 2007). Thesis adviser: Kandatege Wimalasena. Includes bibliographic references (leaves 144-163).
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Otto, Andreas. "Ringtransformationen an chiralena-Alkylidenlactonen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 1999. http://dx.doi.org/10.18452/14473.

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Ziel dieser Arbeit ist die Synthese neuer optisch aktiver Hydroxyalkylheterocyclen durch Ringtransformationen von chiralen -Alkylidenlactonen. Hierzu wurden letztere gezielten Additionen von Binucleophilen, 1,3-dipolaren Cycloadditionen, Cupratadditionen und Epoxidierungsreaktionen unterworfen. Die erhaltenen Produkte konnten durch weitere gezielte Folgereaktionen, Spaltungen oder Reaktionen mit Nucleophilen zu interessanten enantiomerenreinen Hydroxyalkylheterocyclen umgesetzt werden. Eine Deutung der acyclischen Seitendifferenzierung gelang mit Hilfe des antiperiplanaren Effektes und des inside alkoxy effects. Umsetzungen mit Hydrazinen führten in guten Ausbeuten zu trans-Hydroxyalkyl-3-pyrazolidinonen. Aus Nitromethan und -Alkylidenlactonen erhält man DBU-katalysiert Nitroethyllactone die sich unter hydrogenolytischen Reaktionsbedingungen zu trans-3-Hydroxyalkyl-2-pyrrolidinonen ringtransformieren lassen. Über o-Aminothiophenoladditionen und Ringtransformationen werden enantiomerenreine 3-(2-Hydroxyalkyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one erhalten, die neuartige Analoga der Pharmaka Dilthiazem und Thiazesim darstellen. Neue D1-Pyrazoline entstehen durch 1,3-dipolare Cycloadditionen von Diazoalkanen an -Alkylidenlactone. Durch photolytische Extrusion von Stickstoff werden neue chirale Cyclopropanderivate erhalten. Enantiomerenreine , -Diaminosäurederivate werden durch hydrogenolytische N-N-Bindungsspaltung der D1-Pyrazoline generiert. Über Epoxidierung der -Alkylidenlactone mittels Dimethyldioxiran und Umsetzung der erhaltenen Oxirane mit verschiedenen N- und S-Nucleophilen und anschließender Ringtransformation, ist ein Zugang zu Benzothiazepin-4(5H) -on, 1,5-Benzodiazepin-2-on, 1,4-Thiazepan-5-on, Thiomorpholin-2-on, 1-Phenyl-2-acetidion sowie über Lithium-Halogenaustausch-Reaktion zu 2-Hydroxy-2-hydroxyethyl- thiochromen-4-on erarbeitet worden. Mit Organokupferverbindungen gelingt hochregioselektiv die 1,4-Addition. Unter Bedingungen der Iodlactonisierung werden aus den Addukten neuartig substituierte -Butyro- und -Valerolactone erhalten.
The thesis is focused on the synthesis of new optically active hydroxyalkyl heterocycles by ring-chain-transformation of chiral -alkylidenlactones. The latter were subjected to specific additions of binucleophiles to 1,3-dipolare cycloadditions to addition of cuprates and to epoxidation. The product obtained could be further applied in the synthesis of interesting enantiomerically pure hydroxyalkyl heterocycles by specific reactions like ring-cleavage or reactions with nucleophiles. The acyclic side differentiation could be explained with the help of the antiperiplanar effect and the inside alkoxy effects. Reactions with hydrazines led to trans-hydroxyalkyl-3-pyrazolidinones in good yields. Nitroethyllactones were obtained from -alkylidenlactones and nitromethane under DBU-catalysis. In a following step they are ring-transformed into trans-3-hydroxyalkyl-2-pyrrolidinones by hydrogenation. Enantiomerically pure 2-hydroxyalkyl-2,3-dihydro-1,5-benzothiazepin-4-(5H)ones could be prepared by addition of o-aminothiophenol and following ring-chain-transformation. These compounds represent novel analogs of the drugs Dilthiazem™ and Thiazesim™. Novel D1-pyrazoline results from 1,3-dipolare cycloadditions of -alkylidenlactone with diazoalkanes. New chiral derivatives of cyclopropanes were obtained by photolytic extrusion of nitrogen. Enantiomerically pure ,-diaminoacid derivatives were generated by hydrogenolytic cleavage of the N-N-bond of the pyrazolines. Epoxidation of -alkylidenlactones with dimethyldioxirane and opening of the oxirane ring obtained by various N- and S-nucleophiles provided new methods for the synthesis of benzothiazepin-4(5H)-one, 1,5-benzodiazepin-2-one, 1,4-thiazepan-5-one, thiomorpholin-2-one and 1-phenyl-2-acetidione. 2-Hydroxy-2-hydroxyethyl-thiochromen-4-one could be obtained by lithium-halogens exchange reaction. The 1,4-additions of organocuprates to -alkylidenlactones succeeded with high regioselectivity. Novel substituted [gamma]-butyro- and -valerolactones were obtained by iodolactonisations of these adducts.
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Hamze, Khalil. "Baeyer-Villiger monooxygenases d'Acinetobacter : réactions biocatalysées et dédoublements cinétiques dynamiques." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4311/document.

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L'oxydation de Baeyer-Villiger (BV) par voie enzymatique est une méthode efficace pour obtenir de lactones sous forme énantiomériquement pure. Les Baeyer-Villiger Monooxygénases (BVMO) sont ainsi capables d'oxyder de nombreux substrats avec une stéréospécificité remarquable.Nous avons recherché de nouvelles enzymes dans le génome de deux souches appartenant au genre Acinetobacter, A. baylyi ADP1 et A. baumannii AYE. Six gènes ont été clonés dans E. coli. Leur profil de substrat a été étudié en utilisant des cellules entières de ce microorganisme recombinant comme biocatalyseur. Quatre enzymes ont montré une spécificité de substrat similaire, avec une préférence pour les petites cétones cycliques et pour les substituants aryliques. Une de ces enzymes a permis le Dédoublement Cinétique Parallèle Régiodivergent d'une bicyclohepténone et la désymétrisation de cyclobutanones benzyliques avec, dans chaque cas, une énantiosélectivité intéressante car conduisant à des énantiomères rarement obtenus par réaction de BV enzymatique.Dans une seconde partie, des Dédoublements Cinétiques Dynamiques, associant réaction de BV enzymatique et racémisation in situ ont été réalisés avec des cellules entières d'E. coli produisant la Cyclohexanone Monooxygenase (CHMO) issue d'A. calcoaceticus. La racémisation de cyclohexanones α-substituées, habituellement difficilement racémisables, a été assurée par l'emploi de solutions tampons à base de sels de phosphate ou de glycine. Les -caprolactones correspondantes ont été isolées sous forme d'esters méthyliques hydroxylés quasi énantiopurs avec des rendements compris entre 70 et 80%
Enzyme-mediated Baeyer-Villiger oxidation is nowadays largely recognized as an efficient method to obtain highly optically active lactones. An increasing number of Baeyer-Villiger Monooxygenases from various sources has been found to oxidize a large range of substrates with a good to excellent stereospecificity.Firstly, in order to enlarge the scope of these biotransformations, the genome of two strains of the Acinetobacter genus, A.baylyi ADP1 and A.baumannii AYE was explored. Six genes were expressed in E. coli and the substrate profile of each enzyme was studied using whole cell biotransformations. Four enzymes showed close substrate specificity with a preference for small cyclic ketones and for arylic substituents. Interestingly, one enzyme led to a Kinetic Parallel Regiodivergent Resolution of a bicycloheptenone and desymmetrisation of benzylic cyclobutanones in an enantiocomplementary manner when compared to the most of already known enzymes.The second part of this work describes the implementation of Dynamic Kinetic Resolution processes combining enzymatic BV oxidation and in situ racemization of α-substituted cyclohexanones to afford corresponding lactones in more than 50% yield. Cyclohexanone Monooxygenase (CHMO) from another Acinetobacter strain, A. calcoaceticus, was selected and the reactions were carried out with whole cells of producing CHMO E. coli strain. The racemization of α-substituted cyclohexanones, usually slowly racemized under basic conditions, was ensured by the use of containing phosphate salts or glycine buffer solutions. Several corresponding -caprolactones were isolated after methylation as enantiopure hydroxy methyl esters in 70-80% yield
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David, Hamon Catherine. "Synthese asymetrique de lactones : application a la serie des acides meviniques, inhibiteurs de la biosynthese du cholesterol." Poitiers, 1988. http://www.theses.fr/1988POIT2203.

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La compactine et la mevinoline sont des inhibiteurs de l'hmg-coa reductase, enzyme qui transforme l'hmg-coa en acide mevalonique dans une des premieres etapes de la biosynthese du cholesterol. Ces inhibiteurs sont caracterises par un squelette decalinique lie a un systeme lactonique dont la presence est indispensable a l'activite biologique. La preparation d'analogues necessite de disposer d'un synthon chiral qui peut etre obtenu a partir d'un sucre de la serie d. Plusieurs methodes de desoxygenation en positions 2 et 4 a partir de sucres divers (glucose, mannose, galactose) ont ete etudiees. Elles reposent sur l'hydrogenolyse de derives halogenes ou soufres. C'est ainsi qu'en utilisant l'anhydro-1,6 d-glucose la lactone recherchee est tenue en seulement 6 etapes
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Books on the topic "Asymmetric synthesis. Lactones"

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Doran, Robert. Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1.

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Doran, Robert. Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Springer, 2016.

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Book chapters on the topic "Asymmetric synthesis. Lactones"

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Coulter, Matthew M., and Vy M. Dong. "Enantioselective Synthesis of Lactones via Rh-Catalyzed Ketone Hydroacylation." In Asymmetric Synthesis II, 279–84. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527652235.ch35.

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Doran, Robert. "Asymmetric Synthesis of Tertiary α-Aryl Ketones by Decarboxylative Asymmetric Protonation." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 127–75. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_6.

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Doran, Robert. "Introduction to the Total Synthesis of Lactone-Containing Natural Products Using ZrCl4." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 1–11. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_1.

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Doran, Robert. "Asymmetric Synthesis of Both Enantiomers of a δ-Lactone Analogue of Muricatacin." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 35–56. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_3.

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Doran, Robert. "Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary α-Aryl Ketones." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 57–102. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_4.

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Doran, Robert. "Asymmetric Synthesis of the β-Methyl-Substituted Analogues of (+)-Tanikolide and (–)-Malyngolide." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 13–34. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_2.

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Doran, Robert. "A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 103–25. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_5.

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Reddy, M. Venkat Ram, Herbert C. Brown, and P. Veeraraghavan Ramachandran. "Syntheses of Chiral Lactones via Asymmetric Allylboration." In ACS Symposium Series, 220–34. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0783.ch016.

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Chen, S., E. C. Salo, and N. J. Kerrigan. "Asymmetric Synthesis of β-Lactones." In Lewis Base and Acid Catalysts, 1. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-204-00205.

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Lambert, Tristan H. "Construction of Stereochemical Arrays." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0045.

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The unprecedented enantioselective 1,8-addition of azlactone 1 to acylpyrrole 2 catalyzed by triaminophosphorane 3 was reported (J. Am. Chem. Soc. 2012, 134, 19370) by Takashi Ooi at Nagoya University. Tomislav Rovis at Colorado State University developed (Angew. Chem. Int. Ed. 2012, 51, 12330) the asymmetric oxidative hetero-Diels-Alder reaction of propionaldehyde (5) and ketone 6 to produce lactone 8, catalyzed by NHC catalyst 7 in the presence of phenazine. A related NHC catalyst 11 was utilized (Angew. Chem. Int. Ed. 2012, 51, 8276) by Xue-Wei Liu at Nanyang Technological University for the homoenolate addition of enal 9 to nitrodiene 10 to furnish 12 with high ee. The vinylogous conjugate addition of butenolide 13 to 15 to produce 16 with exquisite stereoselectivity was accomplished (Angew. Chem. Int. Ed. 2012, 51, 10069) by Kuo-Wei Huang at KAUST, Choon-Hong Tan at Henan University and Nanyang Technological University, and Zhiyong Jiang at Henan University. The enantioselective production of lactone 18 was achieved (J. Am. Chem. Soc. 2012, 134, 20197) by Jeffrey S. Johnson at the University of North Carolina at Chapel Hill by dynamic kinetic resolution (DKR) of α-keto ester 17. A related DKR strategy was employed (Org. Lett. 2012, 14, 6334) by Brinton Seashore-Ludlow at the KTH Royal Institute of Technology and Peter Somfai at Lund University in Sweden and the University of Tartu in Estonia for hydrogenation of α-amino-β-ketoester 19 to furnish aminoalcohol 21 with high Shigeki Matsunaga and Motomu Kanai at the University of Tokyo developed (Angew. Chem. Int. Ed. 2012, 51, 10275) a unique strategy for the selective production of the cross-aldol adduct 24 by in situ generation of an aldehyde enolate from allyloxyborane 23 under rhodium catalysis. The highly diastereoselective construction of adduct 26 bearing two adjacent quaternary stereocenters by ketone allylation with allyl sulfide 25 was reported (Angew. Chem. Int. Ed. 2012, 51, 7263) by Takeshi Takeda at the Tokyo University of Agriculture and Technology. Wen-Hao Hu at East China Normal University reported (Nature Chem. 2012, 4, 733) the enantioselective three-component coupling of diazoester 27, N-benzylindole (28), and imine 29 to furnish 31 under the action of Rh2(OAc)4 and phosphoric acid 30.
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