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1

Policy, Toronto Working Group on Cholesterol. Detection and management of asymptomatic hypercholesterolemia: A policy document. s.n., 1989.

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2

Engelken, Laura C. Community HIV prevention [course materials. University of California, Santa Cruz, 2001.

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3

Larry, Olsen, American Public Health Association, Centers for Disease Control and Prevention., and U.S. Department of Health & Human Services., eds. Communicable disease control: Self-study course SS3012. American Public Health Association, 1998.

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4

Centers for Disease Control (U.S.). Center for Professional Development & Training., ed. Communicable disease control, homestudy course 3012-G. 5th ed. Center for Professsional Development anhd Training, U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, 1986.

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5

Murphy, Robin. Homeopathic pediatric course: Topics and remedies. Davidson, 1985.

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6

Diana, Kuh, and Ben-Shlomo Yoav, eds. A life course approach to chronic disease epidemiology. 2nd ed. Oxford University Press, 2004.

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7

Centers for Disease Control (U.S.). Training and Laboratory Program Office. Division of Training., ed. Foodborne disease control: Self-study course 3016-G. 5th ed. U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, Training and Laboratory Program Office, Division of Training, 1988.

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8

Diana, Kuh, and Ben-Shlomo Yoav, eds. A life course approach to chronic disease epidemiology. Oxford University Press, 1997.

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9

Heartworm Symposium (1988 Leura, NSW). Heartworm Symposium: Refresher Course for Veterinarians, 5-7 July, 1988. Post Graduate Committee in Veterinary Science, University of Sydney, 1988.

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10

Dalgalarrondo, Sébastien. Sida: La course aux molécules. Editions de l'Ecole des hautes études en sciences sociales, 2004.

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11

Centers for Disease Control (U.S.). Training and Laboratory Program Office., ed. Self-study course 3014-G, waterborne disease control: Manual. U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, Training and Laboratory Program Office, 1987.

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12

Centers for Disease Control (U.S.). Training and Laboratory Program Office., ed. Self-study course 3014-G, waterborne disease control: Manual. U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, Training and Laboratory Program Office, 1987.

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13

Brian, Wisdom G., and Queen's University of Belfast. School of Biology and Biochemistry., eds. Proteins in disease and therapy: MB/BDS course, Year 2, Semester 1. School of Biology and Biochemistry, Queen's University of Belfast, 1997.

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14

Adair, Colin G. Gastrointestinal disease: The upper gastrointestinal tract : a self-study course for pharmacists. Edited by Mawhinney W. Michael, Morrow N. C, and Northern Ireland Centre for Postgraduate Pharmaceutical Education and Training. Northern Ireland Centre for Postgraduate Pharmaceutical Education and Training, 1994.

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15

Adair, Colin G. Gastrointestinal disease: The upper gastrointestinal tract : a self-study course for pharmacists. 2nd ed. Edited by Mawhinney W. Michael, Morrow N. C, and Northern Ireland Centre for Postgraduate Pharmaceutical Education and Training. Northern Ireland Centre for Postgraduate Pharmaceutical Education and Training, 1995.

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16

Larney, Sarah. Orientation on harm reduction: Three-hour training course : Participant manual. WHO, Western Pacific Region, 2007.

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17

Veraska, Don. 29 cases that set the course on AIDS/HIV: A plain English guide. Edited by Drymon Tom and Buraff Publications. Buraff Publications, 1992.

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18

Suinn, Richard M., and Gary R. VandenBos, eds. Cancer patients and their families: Readings on disease course, coping, and psychological interventions. American Psychological Association, 1999. http://dx.doi.org/10.1037/10338-000.

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19

1960-, Day Michael J., and Sellon Rance Kenneth 1959-, eds. Immunity & disease: The TG Hungerford refresher course for veterinarians, 14-18 June 1999. Post Graduate Foundation in Veterinary Science, University of Sydney, 1999.

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20

Western Australia. Environmental Health Service., ed. Busselton mosquito control course: Broadwater Beach Resort, Busselton, 7-11 September, 1998. Environmental Health Service, 1998.

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21

W, Fogel Robert, and National Bureau of Economic Research., eds. Changes in the disparities in chronic disease during the course of the twentieth century. National Bureau of Economic Research, 2004.

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22

Centers for Disease Control (U.S.). Public Health Practice Program Office. Self-study course 3031-G: Reading and interpreting ; the HIV-1 Western Blot test. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Public Health Practice Program Office, 1990.

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23

Ives, Eli. Lectures on the diseases of children: The first American academic course in pediatrics. H.A. Pearson?, 1986.

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24

ACCORD (Umhlanga Rocks, South Africa), ed. Training of trainers course for women in peace making and negotiation (incorporating gender and HIV/AIDS). IGAD, 2004.

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25

Muganga, Jonathan. Information, education and communication (IEC) on "AIDS" in Uganda: Research paper on diploma training course of African communicators on primary health care. University of Tampere, Unit of Peace Research and Development Studies, 1988.

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26

Remmel, Triin. Primary biliary cirrhosis in Estonia: Epidemiology, clinical characterization and prognostication of the course of the disease. Tartu University Press, 1996.

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27

Cader, Sarah. Screening for neurological disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0355.

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Given the nature of some neurological diseases to become progressively disabling, early detection and treatment would be very welcome. However, screening for neurological illnesses in the general population has a number of problems. There are only a few neurological conditions that exist in a detectable asymptomatic state prior to development of clinical disease, and a small number of other conditions have early symptomatic stages before the full impact of the disease manifests. In addition, in many neurological conditions, there are no definitive treatments available. There are, of course, ma
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28

Banerjee, Amitava, and Kaleab Asrress. Screening for cardiovascular disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0351.

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Screening involves testing asymptomatic individuals who have risk factors, or individuals who are in the early stages of a disease, in order to decide whether further investigation, clinical intervention, or treatment is warranted. Therefore, screening is classically a primary prevention strategy which aims to capture disease early in its course, but it can also involve secondary prevention in individuals with established disease. In the words of Geoffrey Rose, screening is a ‘population’ strategy. Examples of screening programmes are blood pressure monitoring in primary care to screen for hyp
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29

Laureno, Robert. Asymptomatic Disease. Edited by Robert Laureno. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190607166.003.0008.

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This chapter on “Asymptomatic Disease” examines the discovery and management of asymptomatic neurologic diseases. Considered are carotid stenosis, berry aneurysm, arteriovenous malformation, and pseudotumor cerebri. Asymptomatic disease can be discovered by routine physical examination or by diagnostic tests that have been ordered for some unrelated reason. Discovery of asymptomatic disease is not always accidental; practitioners sometimes search for asymptomatic brain disease. Such testing can be prompted by the family history, the patient’s personal history, or the clinical situation. After
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30

Asymptomatic Coronary Artery Disease and Angina. Science Press, 1996.

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31

Asymptomatic Coronary Artery Disease and Angina. Science Press Ltd, 1995.

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32

Bergmann, Carsten, Nadina Ortiz-Brüchle, Valeska Frank, and Klaus Zerres. The child with renal cysts. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0305.

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Renal cysts of different aetiology are a common diagnosis in paediatric nephrology. The classification is usually based on the clinical picture, morphology, and family history. In syndromic forms, additional features have to be evaluated. Most common are cystic dysplastic kidneys with a broad phenotypic spectrum ranging from asymptomatic clinical courses in unilateral cases to severe, lethal manifestations in patients with considerable bilateral involvement. Simple cysts are rare. Polycystic kidneys are usually subdivided according to the mode of inheritance into autosomal recessive and autoso
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33

Hochman, Michael E. Screening for Coronary Artery Disease in Asymptomatic Patients with Diabetes. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190223700.003.0019.

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This chapter, found in the chest pain section of the book, provides a succinct synopsis of a key study examining the use of computed tomography (CT) for screening asymptomatic patients with diabetes for coronary artery disease. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. The study showed that screening stress tests in patients with type 2 diabetes are abnormal 22% of the time. However, detecting these abnormalities does not appear to aid in patient management. In additi
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34

Hage, Fadi G., Ayman Farag, and Gilbert J. Zoghbi. Screening Asymptomatic Subjects. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0016.

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Cardiovascular disease is the leading cause of death in the United States and accounts for more deaths than all cancers combined. Many apparently healthy adults first present to the health system with a myocardial infarction or sudden cardiac death. It is therefore imperative to assess the risk of cardiovascular events among currently asymptomatic individuals to try and intervene early in the disease process to prevent future events. Risk factors for the development of coronary artery disease in particular, and cardiovascular disease in general, have been identified from epidemiological studie
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35

Zhou, Yongxia. Typical Imaging in Atypical Parkinson's, Schizophrenia, Epilepsy and Asymptomatic Alzheimer's Disease. Nova Science Publishers, Incorporated, 2021.

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36

Zhou, Yongxia. Typical Imaging in Atypical Parkinson's, Schizophrenia, Epilepsy and Asymptomatic Alzheimer's Disease. Nova Science Publishers, Incorporated, 2021.

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37

Reynard, John, and Ben Turney. Watchful waiting for stone disease. Edited by John Reynard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0020.

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Renal stones are highly prevalent and while many cause symptoms or are of a size that requires treatment even if asymptomatic, the natural history of stones suggests that treatment may not be necessary in all cases. Stone size, position, and number are related, to a degree, to the likelihood of a subsequent stone event such as stone migration causing ureteric colic or increase in stone size, but the predictive power of ‘natural history’ studies is limited by the small number of patients in these studies. In this chapter, the evidence for watchful and waiting for asymptomatic stone disease is e
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38

Brusse, Esther, Pascal Laforêt, and Ans T. van der Ploeg. Danon Disease. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0056.

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Danon disease, like Pompe disease, is a muscle disorder caused by a primary defect in lysosomal proteins. Danon disease (OMIM #300257) is an X-linked dominant disorder, with males being more severely affected than female carriers. In males, mean disease onset is in their early teens and in females in their late twenties. Clinical hallmarks are a severe cardiomyopathy, muscle weakness, and mild mental retardation. Retinal, liver, and pulmonary disease may also occur. Milder, sometimes isolated cardiac phenotypes without mental retardation are also described. Regular cardiac evaluation, even in
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39

Tribouilloy, Christophe, Patrizio Lancellotti, Ferande Peters, José Juan Gómez de Diego, and Luc A. Pierard. Heart valve disease (aortic valve disease): aortic regurgitation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0033.

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Echocardiography is the cornerstone examination for the assessment of aortic regurgitation (AR): it provides reliable evaluation of the aortic valve and allows diagnosis and identification of the mechanism of regurgitation. The specific aetiology of the disease can be identified in the majority of cases. A combination of quantitative and quantitative Doppler and two-dimensional (2D) echocardiographic parameters allows the evaluation of the severity of AR and determination of the haemodynamic and left ventricular function repercussions. Echocardiography allows the detection of associated lesion
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40

Prasad, Abhiram. Ischemic Heart Disease. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0045.

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Ischemic heart disease, principally myocardial infarction, causes approximately 1 of 3 deaths in the United States, or nearly 800,000 deaths annually. The substantial decrease in the death rate from acute myocardial infarction that has occurred since 1970 is attributed to efforts in primary prevention and new interventions in the treatment of myocardial infarction. The variable presentation of patients with coronary heart disease includes patients who are asymptomatic (with or without silent ischemia), patients who have stable or unstable angina or myocardial infarction, and patients with sudd
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41

Rigo, Fausto, Covadonga Fernández-Golfín, and Bruno Pinamonti. Dilated cardiomyopathy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0043.

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Dilated cardiomyopathy (DCM) is characterized by a globally dilated and dysfunctioning left ventricle (LV). Therefore, echocardiographic diagnostic criteria for DCM are a LV end-diastolic diameter greater than 117% predicted value corrected for age and body surface area and a LV ejection fraction less than 45% (and/or fractional shortening less than 25%). Usually, the LV is also characterized by a normal or mildly increased wall thickness with eccentric hypertrophy and increased mass, a spherical geometry (the so-called LV remodelling), a dyssynchronous contraction (typically with left bundle
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42

Rafii, Michael S. Alzheimer’s Disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0016.

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Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and is characterized by a protracted asymptomatic phase estimated to begin approximately 15 to 20 years. Clinically, AD initially manifests itself by progressive memory impairment, specifically, a loss of episodic memory function characterized by impaired free recall that does not improve with cueing. This is followed by a gradual decline in other cognitive domains leading to functional dependency, which essentially defines the dementia phase of the illness and has been the cornerstone of diagnostic criteria. About 50% of
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43

The physiological responses of asymptomatic post-PTCA subjects with positive exercise tolerance tests. 1990.

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44

The physiological responses of asymptomatic post-PTCA subjects with positive exercise tolerance tests. 1991.

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45

Lleó, Alberto, and Rafael Blesa. Clinical course of Alzheimer’s disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198779803.003.0004.

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Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, with onset usually in late life, characterized by progressive cognitive impairment, a variety of behavioural symptoms, and impairment in the activities of daily living. The initial symptom in typical AD is episodic memory loss, which reflects hippocampal dysfunction. The memory deficits are very characteristic with low recall performance despite retrieval facilitations with cueing. These initial deficits can be identified by appropriate cognitive tests. Behavioural symptoms can be present at early stages of the disease (eve
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46

Lleo, Alberto, and Rafael Blesa. Clinical course of Alzheimer’s disease. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199569854.003.0002.

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• Alzheimer’s disease is an age-related neurodegenerative disorder, with onset usually in late life, characterized by cognitive impairment, a variety of behavioural symptoms, and restrictions in the activities of daily living• The initial symptom is episodic memory loss, in particular in delayed recall of visual and/or verbal material. Immediate and remote memory is usually preserved in early stages...
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47

Herrington, William G., Aron Chakera, and Christopher A. O’Callaghan. Diabetic renal disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0164.

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Diabetic nephropathy is kidney damage occurring as a result of diabetes mellitus. Overt diabetic nephropathy is defined as proteinuria greater than 0.5 g/day. Diabetic nephropathy has a complicated pathogenesis including glomerular hypertension with hyperfiltration and advanced glycation end products. Poor glycaemic control is associated with progression to microalbuminuria and overt diabetic nephropathy. The lifetime risk is fairly equivalent for type 1 and type 2 diabetes mellitus. Early disease is usually asymptomatic. Hyperglycaemia causes an osmotic diuresis and, thus, diabetes can presen
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48

Javaid, Kassim. Paget’s disease of bone. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0274.

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Paget’s disease of bone is an uncommon bone disorder with increased bone resorption and disorganized bone formation of woven bone. Its cause is unclear; there is a clear genetic component but additional environmental factors are important, given the reduction in severity and prevalence in the UK. Paget’s disease is usually asymptomatic and detected by an unexplained raised alkaline phosphatase on routine biochemistry. Symptoms include focal bone pain, including headache. Other symptoms include bone deformity and complications such as fracture and nerve conduction. Paget’s disease can sometimes
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49

Chakera, Aron, William G. Herrington, and Christopher A. O’Callaghan. Screening for kidney disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0353.

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Renal disease is common and, with routine reporting of estimated glomerular filtration rates, impairment of renal function is increasingly being recognized. As renal impairment is usually asymptomatic until very advanced, chronic kidney disease (CKD) guidelines have been developed to improve the identification and screening of at-risk populations. Target groups include patients with vascular risk factors (e.g. diabetes mellitus and hypertension); patients with certain multisystem diseases which can cause renal impairment; patients with urological conditions; patients on nephrotoxic medication;
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50

BIOLOGY OF HEALTH & DISEASE (Course U205). Open University, 1985.

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