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Journal articles on the topic 'Asymptomatic course of the disease'

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1

Jo, Kyung-Il, Je Young Yeon, Seung-Chyul Hong, and Jong-Soo Kim. "Clinical Course of Asymptomatic Adult Moyamoya Disease." Cerebrovascular Diseases 37, no. 2 (2014): 94–101. http://dx.doi.org/10.1159/000356350.

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2

Karavaeva, Galina S. "Asymptomatic course of Forestier's disease (clinical case)." Tambov Medical Journal, no. 4 (2022): 53–59. http://dx.doi.org/10.20310/2782-5019-2022-4-4-53-59.

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Diffuse idiopathic skeletal hyperostosis, or Forestier's disease, is a rare disease of the musculoskeletal system, leading to calcification of ligaments and tendons and, as a consequence, to ankylosing due to bone proliferation in the places of the tendon and ligamentous apparatus of the spine. As radiation imaging shows, the disease features are uniform ossification of anterior longitudinal ligament, mainly of thoracic spine, as well as damage to entheses. The disease may be detected accidentally and not manifest itself for many years, or it may be asymptomatic. In some cases, Forestier's dis
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Tsukagoshi, Hiroyuki, Daisuke Shinoda, Mariko Saito, et al. "Relationships between Viral Load and the Clinical Course of COVID-19." Viruses 13, no. 2 (2021): 304. http://dx.doi.org/10.3390/v13020304.

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To predict the clinical outcome of coronavirus disease-2019 (COVID-19), we examined relationships among epidemiological data, viral load, and disease severity. We examined viral loads of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in fatal (15 cases), symptomatic/survived (133 cases), and asymptomatic cases (138 cases) using reverse transcription quantitative real-time PCR (RT-qPCR). We examined 5768 nasopharyngeal swabs (NPS) and attempted to detect the SARS-CoV-2 genome using RT-qPCR. Among them, the viral genome was detected using the method for the 370 NPS samples wit
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4

Kuroda, Satoshi, Nobuo Hashimoto, Takashi Yoshimoto, and Yoshinobu Iwasaki. "Radiological Findings, Clinical Course, and Outcome in Asymptomatic Moyamoya Disease." Stroke 38, no. 5 (2007): 1430–35. http://dx.doi.org/10.1161/strokeaha.106.478297.

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5

Kim, Cherry, Wooil Kim, Ji Hoon Jeon, et al. "COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load." PLOS ONE 16, no. 4 (2021): e0250358. http://dx.doi.org/10.1371/journal.pone.0250358.

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Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also i
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6

Bae, Seongman, Ji Yeun Kim, So Yun Lim, et al. "Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19." Viruses 13, no. 11 (2021): 2133. http://dx.doi.org/10.3390/v13112133.

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We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of t
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7

Mazurov, Vadim I., Roman A. Bashkinov, Alexandra Yu Fonturenko, et al. "Features of the course of rheumatoid arthritis and osteoarthritis in patients with asymptomatic hyperuricemia." HERALD of North-Western State Medical University named after I.I. Mechnikov 12, no. 3 (2020): 63–72. http://dx.doi.org/10.17816/mechnikov44234.

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Introduction. According to numerous studies, the prevalence of asymptomatic hyperuricemia has increased in most countries. Uric acid is an important biomarker of the cardiovascular system, and there are now quite a big number of sources indicating its role in the development of a some chronic metabolic conditions, cardiovascular disease and associated mortality. At present, there is no consensus on the need for urate-lowering therapy in patients with asymptomatic hyperuricemia. There is a limited number of studies examining the problem of asymptomatic hyperuricemia in patients with rheumatic d
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8

Hutchinson, Joseph. "The principles and pitfalls of screening in primary care." InnovAiT: Education and inspiration for general practice 14, no. 9 (2021): 572–77. http://dx.doi.org/10.1177/17557380211021117.

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Screening is the investigation of undiagnosed disease in asymptomatic patients. Asymptomatic disease tends to occur before symptomatic disease, meaning screening should identify disease earlier in its course. Early disease is usually easier to treat, with less morbidity and mortality. Therefore, in theory, screening should reduce morbidity and mortality from disease. The UK has a national population screening programme for specific diseases. Also, GPs regularly perform health screening such as the NHS health check. This must be evidence-based, so that the benefits outweigh harms, and the proce
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9

Parry, Arshed Hussain, Abdul Haseeb Wani, Mudasira Yaseen, Naveed Nazir Shah, and Khurshid Ahmad Dar. "Clinicoradiological course in coronavirus disease-19 (COVID-19) patients who are asymptomatic at admission." BJR|Open 2, no. 1 (2020): 20200033. http://dx.doi.org/10.1259/bjro.20200033.

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Objective: The study aimed to describe the clinical and imaging course of reverse transcriptase polymerase chain reaction) confirmed coronavirus disease (COVID-19) patients who are asymptomatic at admission. Methods: This was a retrospective observational study. Severe acute respiratory syndrome coronavisrus-2 (SARS-CoV-2) positive cases that were asymptomatic at admission were retrospectively enrolled. Specific clinical information, laboratory test results, chest CT imaging features and outcome data during hospital stay were collected and analyzed. Results: 137 non-consecutive asymptomatic pa
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10

Leonova, G. F. "Clinical characteristics of chronic hepatitis C in children with natural course of the disease." Kazan medical journal 95, no. 5 (2014): 757–62. http://dx.doi.org/10.17816/kmj2231.

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Aim. Identification of the clinical features of chronic hepatitis C in children with the natural course of the disease. Methods. Examined were 168 children with chronic hepatitis C in the age of 0-17 years. Features of chronic hepatitis C was determined by the manifestation of infection, duration of disease, route of infection, objective data, the results of clinical and laboratory, instrumental and morphological studies of the dynamics for the period 2000-2013. Results. Depending on the variant of the infection, all children were divided into two groups: those with asymptomatic (121 patients,
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11

Sitdikova, Dinara G., Irina B. Fatkullina, and Liana A. Galiullina. "Obstetric and perinatal aspects of asymptomatic bacteriuria in underage pregnant women." V.F.Snegirev Archives of Obstetrics and Gynecology 10, no. 1 (2023): 67–71. http://dx.doi.org/10.17816/2313-8726-2023-10-1-67-71.

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AIM: This study aimed to investigate the course of pregnancy in underage pregnant women with asymptomatic bacteriuria.
 MATERIALS AND METHODS: A retrospective, comparative analysis of the outpatient records of 70 underage pregnant women was performed. The mean age of the patients was 15.31.7 years. The main group included 35 patients with asymptomatic bacteriuria (AB), and the control group consisted of 35 patients without asymptomatic bacteriuria. The patients were monitored during the entire period of pregnancy and childbirth. Based on the conducted research, a combination of therapeuti
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12

Heidenreich, Axel, Silke Gillessen, Daniel Heinrich, et al. "Radium-223 (Ra-223) in asymptomatic metastatic castration-resistant prostate cancer (mCRPC) patients treated in an international early access program (iEAP)." Journal of Clinical Oncology 35, no. 6_suppl (2017): 158. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.158.

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158 Background: Ra-223, a targeted alpha therapy, is currently used to treat mCRPC patients (pts). To investigate Ra-223 when used early in the disease course, we analyzed safety and efficacy in mCRPC pts with no symptoms at baseline treated in an iEAP. Methods: This was a prospective, single-arm phase 3b study of mCRPC pts (malignant lymphadenopathy not exceeding 6 cm was allowed, visceral disease was excluded). Pts received Ra-223, 55 kBq/kg IV, every 4 weeks for up to 6 cycles. Co-primary endpoints were safety and overall survival (OS). Post hoc analyses were performed according to asymptom
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13

Tiwari, Subodh, Shruti Sharma, and Anita Verma. "Integrated therapy as a tool to help fight asymptomatic COVID-19: A case report." Integrative Medicine Case Reports 2, no. 2 (2021): 55. http://dx.doi.org/10.38205/imcr.020255.

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COVID-19 is a rapidly changing and evolving situation and is extremely challenging to the humankind since it is highly infectious. Around 80% of the COVID-19 patients are asymptomatic but still need special care so that they don’t develop any further serious complications in due course of infection. The aim of present case study was to assess the effect of integrated therapy of yoga and Ayurveda on vital parameters of a COVID-19 positive asymptomatic patient. He was found to be COVID-19 positive with ORF CT value of 29.85. He remained asymptomatic throughout the course of disease. Vital parame
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14

Martusevich, N., S. Duben, A. Aleshkevich, A. Dmitrieva, T. Bondar, and K. Gudkevich. "FRI0386 EARLY OSTEOARTHRITIS: IS ASYMPTOMATIC CLINICAL COURSE REAL?" Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 790.2–791. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6604.

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Background:Osteoarthritis (OA) is the leading cause of disability among all RMDs. Early diagnosis of OA is complicated. So, there is an absence of clear markers of the diagnosis of OA, and this issue is now being discussed.Objectives:The aim of this study is to examine relatively healthy individuals without symptoms in order to evaluate MR-markers of early OA of the knee.Methods:We included 29 relatively healthy individuals. 55,17% (n=16) were women. Median age was 35 (32-41) years. They didn’t have any complaints, according to the preliminary criteria of early OA, symptoms of OA (1), didn’t h
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15

RANTA, J., P. H. MÄKELÄ, A. TAKALA, and E. ARJAS. "Predicting the course of meningococcal disease outbreaks in closed subpopulations." Epidemiology and Infection 123, no. 3 (1999): 359–71. http://dx.doi.org/10.1017/s0950268899003039.

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A stochastic epidemic model was applied to meningococcal disease outbreaks in defined small populations such as military garrisons and schools. Meningococci are spread primarily by asymptomatic carriers and only a small proportion of those infected develop invasive disease. Bayesian predictions of numbers of invasive cases were developed, based on observed data using a stochastic epidemic model. We used additional data sets to model both disease probability and duration of carriage. Markov chain Monte Carlo sampling techniques were used to compute the full posterior distribution which summariz
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16

Klyushnikov, Sergey A. "Huntington’s disease." L.O. Badalyan Neurological Journal 1, no. 3 (2020): 139–58. http://dx.doi.org/10.17816/2686-8997-2020-1-3-139-158.

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Huntingtons disease is one of the most common hereditary neurodegenerative diseases, which remains practically incurable, inevitably leading to the disability of patients and premature death. A fairly wide prevalence in the world, the special severity of the course, the almost complete penetrance of the mutant gene, the peculiarity of clinical and genetic correlations in Huntingtons disease have attracted researchers specializing in neuroscience for many years. The study of the molecular neurobiology of Huntingtons disease over the past decades has largely contributed to significant progress i
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17

Soni, Priyanka, Laxman Kumar Soni, and K. C. Agarwal. "Clinico-radiological profile of COVID-19 in a tertiary care hospital of western Rajasthan." IP Indian Journal of Immunology and Respiratory Medicine 6, no. 3 (2021): 152–55. http://dx.doi.org/10.18231/j.ijirm.2021.033.

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Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection by COVID-19 can result in a range of clinical outcomes, from asymptomatic to severe life-threatening course or death. The purpose of our research was to evaluate the presentation of COVID19 disease based on the clinical and radiological characteristics of our population. 100 COVID19 patients recorded by RTPCR. Clinical, biochemical and radiological data from April-May, 2021. Of the 100 patients, in our study 66% wer
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18

Darchiya, O. V., E. G. Malayeva, I. A. Khudyakov, et al. "HEREDITARY CALCINOSIS OF ARTERIES WITH PERIARTHERIAL CALCINOSIS OF SOFT TISSUES." Health and Ecology Issues, no. 3 (September 28, 2017): 96–100. http://dx.doi.org/10.51523/2708-6011.2017-14-3-21.

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19

Abdel-Aziz, Mosaad, Nada M. Abdel-Aziz, Dina M. Abdel-Aziz, and Noha Azab. "Pediatric COVID-19 and the Factors That May Mitigate Its Clinical Course." Journal of Child Science 10, no. 01 (2020): e137-e140. http://dx.doi.org/10.1055/s-0040-1717077.

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AbstractThe clinical manifestations of novel coronavirus disease 2019 (COVID-19) vary from mild flu-like symptoms to severe fatal pneumonia. However, children with COVID-19 may be asymptomatic or may have mild clinical symptoms. The aim of this study was to investigate clinical features of pediatric COVID-19 and to search for the factors that may mitigate the disease course. We reviewed the literature to realize the clinical features, laboratory, and radiographic data that may be diagnostic for COVID-19 among children. Also, we studied the factors that may affect the clinical course of the dis
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20

Hidayat, Rachmat, and Patricia Wulandari. "Guidelines for the Management of COVID-19 (Coronavirus Disease 2019)." Journal of Anesthesiology and Clinical Research 3, no. 1 (2022): 301–8. http://dx.doi.org/10.37275/jacr.v3i1.241.

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The clinical manifestations of COVID-19 vary widely, ranging from asymptomatic/asymptomatic to very severe respiratory distress. Both the body's immune response, both the natural body's immune response and the adaptive body's immune response, play a very important role in the course of COVID-19. Most patients infected with SARS-CoV-2 show symptoms of the respiratory system such as fever, coughing, sneezing, and shortness of breath. The most common symptoms are fever, dry cough, fatigue, and anosmia or ageusia. The management of COVID-19 focuses on isolation, improving the immune system, and ha
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21

Wiecek, Sabina, Alicja Wojtyniak, Barbara Pindur, Magdalena Machnikowska-Sokołowska, Katarzyna Gruszczyńska, and Urszula Grzybowska-Chlebowczyk. "Analysis of the Clinical Course of Primary Sclerosing Cholangitis in Paediatric Population—Single Center Study." Medicina 57, no. 7 (2021): 663. http://dx.doi.org/10.3390/medicina57070663.

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Background and Objectives: Primary sclerosing cholangitis (PSC) is a rare cholestatic disease of the liver of unknown etiology, severe course and poor prognosis. PSC most often co-occurs with inflammatory bowel diseases (IBD), especially with ulcerative colitis (UC). The aim of the study was the analysis of the clinical course of primary sclerosing cholangitis in children, hospitalized in the Gastroenterology Unit in Katowice. Materials and Methods: The analysis included 30 patients, aged from 7 to 18 years, 21/30 boys (70%) and 9/30 girls (30%), diagnosed with PSC in the years 2009–2019. The
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22

Tayama, Eiki, Satoshi Fujita, Tomohiro Ueda, et al. "Ventricular Septal Defect in an Octogenarian: A Case Report of VSD Surgical Repair Concomitant with Coronary Artery Bypass and Valvular Surgery." Case Reports in Cardiology 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/429569.

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Finding an untreated or asymptomatic large ventricular septal defect (VSD) in an elderly patient is uncommon. The present case was an 81-year-old man who suffered from acute myocardial infarction due to three-vessel coronary disease, mitral and tricuspid valve insufficiency, and high-flow perimembranous VSD (Qp/Qs 2.3). Although the patient was elderly and the VSD had been asymptomatic for a long time, we considered that high-flow VSD and valve diseases should be repaired simultaneously with coronary disease. Then, he underwent elective surgery, namely, VSD patch repair concomitant with corona
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23

Chumenko, Nikolay Leonidovich. "Memo on the procedure in case of asymptomatic or mild course of the disease COVID-19." Glavvrač (Chief Medical Officer), no. 3 (February 20, 2022): 41–46. http://dx.doi.org/10.33920/med-03-2203-04.

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SOGAZ-Med informs about the procedure of citizens' actions in case of asymptomatic or mild course of COVID-19 disease according to the memo of the Ministry of Health of the Russian Federation dated 27.01.2022.
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Van Kerckhove, Catherine, and Andrew Liu. "MASSIVE COVERT INFECTION OF HELPER T LYMPHOCYTES AND MACROPHAGES BY HIV DURING THE INCUBATION PERIOD OF AIDS." Pediatrics 96, no. 2 (1995): 403–4. http://dx.doi.org/10.1542/peds.96.2.403b.

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HIV virus is active in lymphoid tissues even during the asymptomatic stage of the disease. Therefore, a state of true microbiological latency does not exist during the course of HIV infection. The best way to fight HIV-1 disease, therefore, appears to be through prevention and early treatment.
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Van Kerckhove, Catherine, and Andrew Liu. "HIV INFECTION IS ACTIVE AND PROGRESSIVE IN LYMPHOID TISSUE DURING THE CLINICALLY LATENT STAGE OF DISEASE." Pediatrics 96, no. 2 (1995): 403. http://dx.doi.org/10.1542/peds.96.2.403a.

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HIV virus is active in lymphoid tissues even during the asymptomatic stage of the disease. Therefore, a state of true microbiological latency does not exist during the course of HIV infection. The best way to fight HIV-1 disease, therefore, appears to be through prevention and early treatment.
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26

Klimov, N. A., and O. V. Shamova. "Microbiota disorders in bacterial vaginosis and the possibility of personalized therapy of the disease with the use of probiotics (review)." Russian Journal for Personalized Medicine 2, no. 6 (2023): 78–90. http://dx.doi.org/10.18705/2782-3806-2022-2-6-78-90.

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The review presents data on the etiology and treatment of bacterial vaginosis. Bacterial vaginosis is caused by the replacement of a protective microbiota in a lower part of a female reproductive tract with the pathogenic one. This disease is widespread in a world, in some cases it is asymptomatic, but is accompanied by complications, which include chorioamnionitis, inflammatory diseases of the pelvic organs, cervicitis, premature birth. In some cases, the disease is characterized by a recurrent course that requires a personalized treatment.
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27

.Abdallah, Marawan Izzeldin A., Tarig Elhadi Elsidig, Farh Ahmed Elhassan Mohamed, Ghanem M. Mahjaf, and Mosab Nouraldein Mohammed Hamad. "Clinical Course of Asymptomatic and Mildly Symptomatic COVID-19 Patients Who had A Positive PCR Test in Multicenter in Khartoum." SAR Journal of Medicine 3, no. 3 (2022): 29–35. http://dx.doi.org/10.36346/sarjm.2022.v03i03.002.

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Background: While most people follow social distancing and are avoiding contact with anyone displaying flu-like symptoms, still asymptomatic patients are having positive SAR COV 2 test can transfer disease to others, as well as the outcome of their disease sill not well understood. Objective: To assess the clinical course of asymptomatic COVID-19 patients who had a positive PCR test in multicenter. Methods: This was a prospective cohort multicenter study conducted in the study was conducted in Khartoum State COVID-19 Centres. Namely Alia Hospital, Fedail, and Ministry of Health Laboratories du
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28

Wiecek, S., A. Wojtyniak, B. Pindur, and U. Grzybowska-Chlebowczyk. "P024 Evaluation of the clinical course of patients diagnosed with primary sclerosing cholangitis: single centre study." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S143. http://dx.doi.org/10.1093/ecco-jcc/jjz203.153.

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Abstract Background Primary sclerosing cholangitis (PSC) is a rare liver cholestatic disease with unknown aetiology, severe clinical course and poor prognosis. PSC most often co-occurs with inflammatory bowel diseases (IBD), especially ulcerative colitis (UC). The aim of the study. We aimed to analyse the clinical course of patients diagnosed with PSC hospitalised in the Department of Gastroenterology, Medical University of Silesia in Katowice in 2009–2018. Methods The analysis included 30 patients, aged from 7 to 18 years (mean age 13.5 years), 21/30 boys (70%) and 9/30 girls (30%), diagnosed
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29

Gąbka, Ilona, Weronika Dalmata, Karolina Gendek, et al. "Hashimoto's disease - the role of factors and diet in the course of the disease." Journal of Education, Health and Sport 17, no. 1 (2023): 153–64. http://dx.doi.org/10.12775/jehs.2023.17.01.014.

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Introduction: Hashimoto's disease is an autoimmune disorder that develops as a result of a pathological reaction of the patient's immune system, which consequently destroys the body's own healthy cells and tissues. Genetic, environmental and immunological factors influence its development. The disease may initially be asymptomatic. The exact aetiology of the disease is unknown. The worldwide incidence is approximately 10-12%.
 Purpose: This paper aims to present the influence of genetic factors, environmental factors, trace elements, and diet on the development and course of Hashimoto's d
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30

Swetha R, Abilasha R, and Dinesh Premavathy. "The Intriguing Course of Coronavirus and its Age Dependent Variation in the Disease Outcome - A Concise Update." International Journal of Research in Pharmaceutical Sciences 11, SPL1 (2020): 1075–78. http://dx.doi.org/10.26452/ijrps.v11ispl1.3527.

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Coronavirus is part of a family of enveloped positive-strand RNA viruses that infect mammals. COVID-19 pandemic which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] has affected hundreds of thousands of people worldwide with a rapid spreading and mutating strain of the virus. Morbidity and mortality of COVID-19 infections vary extensively from asymptomatic, mild to deadly and critical. Strangely, children were found to be protected from severe or deadly critical infections due to various reasons, on the other hand elderly with co-morbidities and immunocompromised adu
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Kaszyńska, Aleksandra, Tadeusz M. Zielonka, and Katarzyna Życińska. "A COUGH IN A PATIENT WITH CHOLANGITIS IN THE COURSE OF CAROLI’S DISEASE. CASE REPORT." Wiadomości Lekarskie 72, no. 2 (2019): 294–97. http://dx.doi.org/10.36740/wlek201902129.

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Cough may be a manifestation of pulmonary and extra-pulmonary diseases. However, rarely liver disease is suspected as a cause of acute cough. A case of a 34-year-old patient with diagnosed Caroli’s disease has been described, in which cough with fever was the main manifestation of cholangitis in the course of complications of the underlying disease. Caroli’s disease is a congenital pathology of intrahepatic bile ducts, causing their cysts to widen. It usually has an asymptomatic course, however it promotes infectious complications such as liver abscesses and recurrent cholangitis. The patient
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32

Bagin, S. A., Р. Е. Krainyukov, Z. Kh Shugushev, et al. "Medium-long-term results of carotid stenting in asymptomic stenosis of the carotid arteries." Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH) 11, no. 2 (2021): 18–27. http://dx.doi.org/10.20340/vmi-rvz.2021.2.clin.3.

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The article describes the experience of carotid stenting use in asymptomatic cerebral atherosclerosis. The study included 147 patients with unilateral asymptomatic carotid artery disease. The evaluation of mid-longterm results of carotid stenting in patients with asymptomatic stenosis was carried out in comparison with the use of conservative treatment in this category of patients (“optimal drug treatment”). In the course of the work, no significant intergroup difference was revealed in the incidence of adverse outcomes (TIA/stroke, death from stroke,) within a year from the moment of surgical
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33

Phillips, Peter. "Diarrhea in the HIV-Infected Patient." Canadian Journal of Infectious Diseases 5, suppl e (1994): 42E—48E. http://dx.doi.org/10.1155/1994/793045.

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Gastrointestinal manifeslations may be encountered throughout, the course of HIV disease. The problems range from asymptomatic hairy leukoplakia lo overwhelming diarrhea due to opportunistic infections such as cryptosporidiosis. Diarrheal disease is an important contributing factor to wasting in advanced HIV disease. Considerable progress has been made in recents years regarding our understanding or HIV-related diarrhea, including etiological agents, diagnostic methods and treatment.
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Bereznai, Benjamin, Anita Trauninger, Ilona György, et al. "Clinical manifestation, disease course and response to enzyme replacement therapy in Hungarian patients with Pompe’s disease." Orvosi Hetilap 152, no. 39 (2011): 1569–75. http://dx.doi.org/10.1556/oh.2011.29184.

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Pompe’s disease is an autosomal recessive disease caused by deficiency of acid-alpha-glucosidase. Aims and Methods: Authors analyzed the phenotype of 11 Hungarian patients with Pompe’s disease and evaluated clinical parameters and response to enzyme replacement therapy during a long-term follow-up in 8 patients. Results: One patient with atypical infantile form presented with cardiomyopathy and a very slow progression of motor deficits; after 2 years of enzyme replacement therapy no disability was present at the age 6 years. Another patient was asymptomatic at the age of 2.5 years. The adult o
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Nasyrova, Zarina Akbarovna. "THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS." journal of cardiorespiratory research 3, no. 3 (2022): 3. https://doi.org/10.5281/zenodo.7145914.

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In recent days, among patients with coronary artery disease, there have been frequent cases of asymptomatic and clinically pronounced hyperuricemia, which threaten the lives of patients with cardiovascular pathologies; therefore, interest in studying the course of hyperuricemia in patients with cardiovascular diseases is increasing. Objective: to study the relationship between the polymorphism of the -819 C/T locus (rs1800871) of the IL-10 gene and the progression of unstable angina in patients with neurosensory disorders.
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Chepurnenko, S. A., M. Yu Kostrykin, G. V. Shavkuta, and M. S. Chepurnenko. "Long-term asymptomatic course of large myxoma in the right atrium." Russian Journal of Cardiology and Cardiovascular Surgery 18, no. 3 (2025): 366. https://doi.org/10.17116/kardio202518031366.

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Myxoma arising from the right atrium accounts for 7—18% of all these tumors. Any myxoma is characterized by classic triad of symptoms with blood flow obstruction, constitutional signs and thromboembolic phenomena. We present a rare variant of asymptomatic course of large myxoma in the right atrium in a 65-year-old man. The tumor was discovered accidentally when the patient visited the clinic due to long-term uncontrollable paroxysm of atrial fibrillation. The neoplasm was attached to anterior wall of the right atrium and did not reach tricuspid annulus. There were no symptoms of blood flow obs
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37

Bijaylaxmi, Behera. "Unusual Presentation of COVID-19 as Atypical Kawasaki Disease in Children." International Journal of Research and Review 7, no. 6 (2020): 279–81. https://doi.org/10.5281/zenodo.3952332.

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Coronavirus disease 2019 has led to a global pandemic, infecting individuals of all ages. Although pediatric population appears to be less affected and maximum cases were asymptomatic, mild or moderate cases but recent reports are showing some worrisome course of this Pandemic. Children are having unusual presentations of a Kawasaki disease (KD)-like inflammatory syndrome associated with COVID-19.  
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38

Rumyantsev, Sergey N. "The Origin of Individual Differences in the Course and Severity of Diseases." Scientific World JOURNAL 6 (2006): 1674–704. http://dx.doi.org/10.1100/tsw.2006.278.

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Any disease manifests itself individually either by a bright or restricted spectrum of clinical signs and resultant clinical courses that range from asymptomatic to deadly, from acute to chronic, etc. Until recently, the origin of this kind of biodiversity was poorly investigated and understood, but advances in immunology — especially in identifying constitutional (genetic) mechanisms of immunity — have contributed to our understanding of the origin of individual diversity in diseases. Any disease destroys only focal areas in the affected organisms, and the amounts, sizes, and distribution of
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39

Vinogradova, Marina, Ekaterina Skvortsova, and Vsevolod Skvortsov. "Changes in the cardiovascular system in patients with diabetes mellitus." Vestnik of Saint Petersburg University. Medicine 19, no. 1 (2024): 4–13. http://dx.doi.org/10.21638/spbu11.2024.101.

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In recent years, there have been serious changes in the close relationship between diabetes mellitus and cardiovascular diseases. From the early stages of insulin resistance and prediabetes to serious cardiac complications caused by diabetes. Coronary heart disease is the main cause of morbidity and mortality in diabetic patients, but not all diabetic patients have an equally high risk of heart attacks. More than a third of asymptomatic patients have no signs of coronary atherosclerosis and have a very low annual heart attack rate. Early detection of patients with subclinical coronary artery a
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40

Gruber, Sven, and Felix Beuschlein. "Hypokalemia and the Prevalence of Primary Aldosteronism." Hormone and Metabolic Research 52, no. 06 (2020): 347–56. http://dx.doi.org/10.1055/a-1134-4980.

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AbstractHypokalemia is closely linked with the pathophysiology of primary aldosteronism (PA). Although hypokalemic PA is less common than the normokalemic course of the disease, hypokalemia is of particular importance for the manifestation and development of comorbidities. Specifically, a growing body of evidence demonstrates that hypokalemia in PA patients is associated with a more severe disease course regarding cardiovascular and metabolic morbidity and mortality. It is also well appreciated that low potassium levels per se can promote or exacerbate hypertension. The spectrum of hypokalemia
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Matsuda, Ryosuke, Takayuki Morimoto, Yasuhiro Takeshima, et al. "COT-12 CLINICAL MANAGEMENT AND TIMING OF SURGICAL TREATMENT FOR ASYMPTOMATIC GLIOMA." Neuro-Oncology Advances 1, Supplement_2 (2019): ii42. http://dx.doi.org/10.1093/noajnl/vdz039.192.

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Abstract BACKGROUND In Japan, there are many cases where intracranial diseases are found accidentally due to the widespread use of MRI and brain check-up. Unruptured cerebral aneurysms and asymptomatic cerebral infarctions are often diagnosed, but asymptomatic glioma is rarely diagnosed. We analyzed the asymptomatic gliomas retrospectively among grade 2 or higher gliomas that had undergone diagnostic imaging or surgical treatment in our institution. MATERIAL AND METHODS Of 166 adults with grade 2 or higher grade glioma treated in our institution between 2007 and 2018, 15 cases were asymptomati
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42

Feehan, Amy K., Daniel Fort, Julia Garcia Diaz, et al. "453. Frequency of Symptoms and Asymptomatic SARS-CoV-2 Infection in New Orleans, Louisiana." Open Forum Infectious Diseases 7, Supplement_1 (2020): S293—S294. http://dx.doi.org/10.1093/ofid/ofaa439.646.

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Abstract Background Individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who do not report symptoms throughout the course of infection (asymptomatic) or those who are asymptomatic when they first contract the virus (presymptomatic) are a major public health concern. However, few prevalence studies to date have targeted the question of asymptomatic frequency within a community. Methods A stratified, random sample of subjects were sent to testing sites to complete a verbal consent, survey, nasopharyngeal swab, and blood draw. Swabs were tested for active viral s
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Dhungana, Sahadeb Prasad, and Sanjib Kumar Sharma. "Multi-Valvular Endocarditis with Underlying Rheumatic Heart Disease: A Case Report." Journal of Nobel Medical College 10, no. 1 (2021): 61–62. http://dx.doi.org/10.3126/jonmc.v10i1.37986.

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The clinical picture of infective endocarditis varies from the asymptomatic stage for a long duration to an acute fulminant course. A high index of suspicion is necessary whenever a patient presents with nonspecific symptoms and some peripheral clinical signs with a cardiac murmur. We report a case of sub-acute IE involving multiple left and right side cardiac valves with underlying rheumatic heart disease (RHD).
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44

Cheng, Xiaoting, Jialin Liu, Ning Li, et al. "Otolaryngology Providers Must Be Alert for Patients with Mild and Asymptomatic COVID-19." Otolaryngology–Head and Neck Surgery 162, no. 6 (2020): 809–10. http://dx.doi.org/10.1177/0194599820920649.

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More than half of COVID-19 patients are afebrile early in the disease course, yet mildly ill or asymptomatic patients can still spread SARS-CoV-2 with high efficiency. Atypically presenting patients may be seen in noninfectious disease settings such as otolaryngology, which is a specialty prone to occupational exposure. Otolaryngologists have been infected with COVID-19 at higher rates than other specialties in China and other countries. Otolaryngology providers should maintain high clinical suspicion for mild and asymptomatic COVID-19 patients. Protective strategies should be implemented incl
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AL Azkawi, Hanan, and Ibrahim AlAlwan. "Two Siblings with Familial Chylomicronemia Syndrome: Disease Course and Effectiveness of Early Treatment." Case Reports in Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/807434.

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There are no adequate data that evaluate the safety and effectiveness of lowering triglyceride levels in very young children. The authors report a family with two male siblings, 7 and 4 years old, affected by familial hyperchylomicronemia. The oldest was diagnosed at birth during evaluation of jaundice, and the youngest showed asymptomatic hypertriglyceridemia by 6 months of age. Due to high triglyceride levels, Gemfibrozil (a fibric acid derivative) was started at diagnosis. Close clinical followup and laboratory monitoring of these children showed no side effects from the drug, and the risk
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Agustiansyah, Patiyus, Rizal Sanif, Siti Nurmaini, Irfannuddin, and Legiran. "Screening for Cervical Cancer." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 3 (2021): 649–58. http://dx.doi.org/10.32539/bsm.v5i3.329.

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Screening is a public health intervention administered to a target populationwithout symptoms. Screening is not performed to diagnose a disease, but toidentify individuals with a higher likelihood of developing the disease itself or aprecursor to the disease. Not all diseases are suitable for screening programs. Thefollowing criteria help determine whether a disease is suitable for a screeningprogram: (1) The disease is bound to have serious consequences. (2) The diseasemust have a detectable preclinical and asymptomatic stage. (3) Treatment at thepreclinical stage should influence the long-te
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Pandit, Lekha, Sharik Mustafa, Ichiro Nakashima, Toshyuki Takahashi, and Kimhiko Kaneko. "MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response." Multiple Sclerosis Journal - Experimental, Translational and Clinical 4, no. 3 (2018): 205521731878782. http://dx.doi.org/10.1177/2055217318787829.

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Objectives We investigated the clinical characteristics and treatment response in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease and looked for evidence of subclinical disease. Methods We prospectively evaluated the frequency and pattern of relapse, tested afferent visual function and monitored treatment response in 42 south Asian patients from a single centre. Results Eighteen patients (42.9%) had monophasic and 24 (57.1%) a relapsing course. Disease duration was longer ( P<0.02) in those with a relapsing course. Median time to the second attack was prolonged ( P
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Dussias, N., L. Melotti, E. Mazzotta, et al. "P706 Monitoring asymptomatic patients with Crohn's disease: the role of intestinal ultrasound." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i837—i838. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0836.

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Abstract Background Intestinal Ultrasound (IUS) is a non-invasive, widely available technique that can rapidly evaluate bowel wall thickness and provide direct visualization of bowel vascularisation and motility. Studies have shown high concordance between ultrasound and MR enterography and endoscopy for disease location and activity, and fewer technical difficulties associated with IUS. While more is known about the role of IUS in evaluating response to pharmacologic treatment in CD patients, data regarding the monitoring of asymptomatic patients are scarce. Our objective was to study the imp
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Dmitrieva, Yu A., A. R. Miyanova, A. D. Gostyukhina, et al. "Celiac disease in children with diabetes: how not to miss it?" Experimental and Clinical Gastroenterology, no. 1 (January 17, 2025): 119–24. https://doi.org/10.31146/1682-8658-ecg-233-1-119-124.

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The pathogenesis of celiac disease is characterized by its frequent association with autoimmune diseases, in particular, with type 1 diabetes mellitus. Possible causes of the association include the presence of common genetic markers in patients, cross-reaction of autoantibodies and activated T-lymphocytes formed in celiac disease with the body’s own antigens, systemic effects of proinflammatory cytokines, and similar provoking environmental factors. Celiac disease associated with type 1 diabetes mellitus is characterized by a low-symptom or asymptomatic course, which leads to untimely diagnos
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50

Dai, Wei, Xinmiao Chen, Xiaoting Xu, et al. "Clinical Characteristics of Asymptomatic Patients with SARS-CoV-2 in Zhejiang: An Imperceptible Source of Infection." Canadian Respiratory Journal 2020 (September 19, 2020): 1–5. http://dx.doi.org/10.1155/2020/2045341.

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Objective. Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, was first identified in December 2019 in Wuhan, China, and has since spread globally, resulting in an ongoing pandemic. However, the study of asymptomatic patients is still rare, and the understanding of its potential transmission risk is still insufficient. In this study, epidemiological investigations were conducted in the Zhejiang province to understand the epidemiology and clinical characteristics of asymptomatic patients with COVID-19. Methods. This retrospective study was carried out on 22 asympto
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