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Relevant bibliographies by topics / Autoimmune Uveitis / Dissertations / Theses

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Dissertations / Theses on the topic 'Autoimmune Uveitis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Dua, Harminder Singh. "Immunomodulation of experimental autoimmune uveitis." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317710.

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Chronic posterior uveitis is a relatively common clinical disorder and an importance cause of visual impairment in young adults. Experimental autoimmune uveitis (EAU) and its associated experimental autoimmune pinealitis (EAP) induced by retinal autoantigens are predominantly CD4+ T cell mediated (auto) immune disease of the retina and uveal tract of the eye and the pineal gland respectively. EAU bears a close clinical and pathological resemblance to chronic posterior uveitis in humans and seves as a good animal model for the study of posterior uveitis. The EAU model was used to study means of

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2

Minas, Konstantinos. "New approaches to autoimmune therapy through gene analysis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted no access until May 19, 2011. Online version available for University member only until May 19, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25620.

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3

Read, Russell W. "The role of complement in experimental autoimmune uveitis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/read.pdf.

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4

Morgan, James. "Analysis of candidate retinal autoantigens in autoimmune uveitis." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415718.

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5

Zhao, Zi-Shan. "T cell effector mechanisms in experimental autoimmune uveitis (EAU)." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294788.

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6

Klaska, Izabela. "Dendritic cell-based therapy of experimental autoimmune uveoretinitis." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196130.

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Recently, there has been considerable interest in developing specific cell-based immunotherapies using dendritic cells (DCs). Here the mechanisms underlying the tolerogenic properties of DCs in the suppression of experimental autoimmune uveoretinitis (EAU), the mouse model of human sight threatening autoimmune uveitis, were examined. Immature DCs have the ability to promote immune tolerance to self antigens and to prevent the development of autoimmune disorders including EAU. However there is a risk that immature DCs placed in the inflammatory environment would undergo maturation and instead o

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7

Hoey, Sharon. "Cytokine-induced nitric oxide mediates tissue damage in experimental autoimmune uveitis." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602036.

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The large amounts of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) has been described as a double-edged sword eliciting pro- or anti inflammatory effects in different immune situations. The aim of this study was to investigate the role of NO in ocular inflammation. Rat RPE cells were shown to produce NO in vitro in response to inflammatory stimuli but in vivo the RPE expressed little or no iNOS enzyme in the normal Lewis rat eye. However, expression of the iNOS enzyme was closely associated with disease activity in experimental autoimmune uveoretinitis (EAU), a model

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8

Kaufmann, Ulrike. "Immunoregulation of monophasic and relapsing experimental autoimmune uveitis in the rat model." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-176686.

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9

Kaufmann, Ulrike [Verfasser], and Gerhild [Akademischer Betreuer] Wildner. "Immunoregulation of monophasic and relapsing experimental autoimmune uveitis in the rat model / Ulrike Kaufmann. Betreuer: Gerhild Wildner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/106287739X/34.

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10

Greiner, Kathrin Heike. "Medical treatment of autoimmune uveitis : clinical and laboratory investigations into new therapies for non-infectious posterior segment intraocular inflammation." Thesis, University of Aberdeen, 2004. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU486816.

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The studies in this thesis were aimed at developing new treatment concepts for PSII based on the understanding of the immunological mechanisms characterised in basic research. The intensity and prognosis of inflammatory disease determine the intensity of immunosuppressive therapy. In addition to clinical features, markers of effective immunosuppression are required to guide the immunosuppressive treatment in PSII patients, especially in those patients with opaque media. A secondary aim of this thesis was, hence, the evaluation of laboratory markers, notably CD4+ T cell phenotype markers, for t

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11

Liversidge, Janet. "Immunoregulatory mechanisms in experimental autoimmune uveitis : the role of major histocompatibility complex products, retinal pigment epithelial cells and mononuclear leucocytes." Thesis, University of Aberdeen, 1989. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU482352.

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In this study a possible role for RPE cells as local antigen presenting cells in immune inflammatory eye disease was investigated. In contrast to observations in the rat model of EAU however, Class II positive RPE cells were never observed in vivo in the guinea pig model of EAU but responses of RPE cells in vitro implied that these cells may have an immunoregulatory role in retinal autoimmunity. The T cell mediated nature of EAU was studied in the guinea pig model. The phenotype of inflammatory cells present in developing lesions was examined. Earliest choroidal infiltrates appeared to be Th c

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12

Judice, De Menezes Relva Lia. "Le rôle des récepteurs aux nucléotides P2Y2 dans le développement d'uvéites autoimmunes." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209265.

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Lors d’uvéite non infectieuse (UNI), des événements environnementaux vont provoquer une rupture de la tolérance immune périphérique et une activation des cellules résidentes oculaires. Plusieurs données attestent de l’importance du rôle joué par les signaux de danger lors de ces deux phases clefs d’activation pathologique. Si une place capitale a été donnée aux signaux de danger exogènes, notamment microbiens, l’importance des signaux de danger endogènes commence à émerger. A ce titre, les nucléotides constituent une famille importante de signaux de danger endogènes puisque en situation pathol

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13

Kezic, Jelena Marie. "A study of the monocyte-derived cell populations of the uveal tract and retina in homeostatic conditions and during the early stages of ocular autoimmune disease." University of Western Australia. School of Anatomy and Human Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0084.

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The eye contains closely related but widely different tissues, offering a unique opportunity to investigate the phenotype and function of monocyte-derived cell populations within functionally unique microenvironments in a single complex organ. The uveal tract and retina contain rich networks of immune cells that reside and traffic through the eye, these cells having been implicated in various ocular inflammatory processes and immune-mediated diseases. One such inflammatory condition is human posterior uveitis, an autoimmune disease mainly affecting the retina. As current treatments for posteri

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14

Makhoul, Maya. "Activation des cellules rétiniennes lors d'uvéites autoimmunes expérimentales: rôle des cytokines pro-inflammatoires et effet du transfert du gène SOCS1." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209688.

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Les uvéites non infectieuses sont considérées actuellement comme une des plus importantes cause de déficience visuelle dans la population des jeunes adultes. Les uvéites non infectieuses sont des atteintes inflammatoires de la rétine et de l’uvée et sont généralement considérées comme autoimmunes et initiées par la perte de la tolérance immune aux protéines rétiniennes. Elles sont orchestrées d’une part, systémiquement par deux sous populations lymphocytaires dont la signature cytokinique est l’IFNγ (Th1) et l’IL-17 (Th17) et d’autre part, localement, par l’activation du tissu rétinien. Néanmo

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15

Sheng-MinHsu and 許聖民. "Development of novel immune mechanism-based therapies for autoimmune uveitis using a mouse model of experimental autoimmune uveitis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/37795041565137983383.

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博士<br>國立成功大學<br>臨床醫學研究所<br>102<br>The purpose of this study is to ameliorate experimental autoimmune uveitis (EAU) in mice as an animal model with tolerogenic antigen presenting cells (TolAPC) or other drugs including proteasome inhibitor bortezomib and N-acetylcysteine and then to investigate the mechanisms. Uveitis refers to inflammation of the uveal tissues and can cause significant ocular morbidities in individuals with protracted diseases. Clinical courses refractory to conventional treatment with corticosteroids are not uncommon, and the adverse effects associated with steroids, such a

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16

Hung, Tun Ywin, and 洪敦筠. "Treatment of Experimental Autoimmune Uveitis by PD-L1 Intraocular Gene Therapy." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/30545904571516813818.

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碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>100<br>Uveitis is a chronic inflammatory eye disease category that affects the uvea and retina and results in vision loss. The inflammation appears to be mainly associated with activation of autoreactive T cells. Many studies have indicated that PD-1 and its ligands (such as PD-L1) negatively regulate immune responses, and interaction between PD-1 and PD-L1 plays a protective role in autoimmune diseases. Therefore, here we sought to develop a PD1-targeting approach to suppress experimental autoimmune uveitis (EAU). Successful construction of rAAV delivery PD-L1 con

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17

Chieh-YuLin and 林倢妤. "The roles of reactive oxygen species in experimental autoimmune uveitis in mice." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/abuqtk.

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18

Hong, Wei Hsin, and 洪薇馨. "Effects of Interleukin-17 on the Disease Development of Experimental Autoimmune Uveitis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/49726521003134008207.

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19

Hsu, Yung-Ray, and 許詠瑞. "Expression of microRNAs in the Eyes of Lewis Rats with Experimental Autoimmune Anterior Uveitis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/09911987421814979621.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>103<br>Purpose To determine the dynamic changes of NF-κB-related microRNAs and cytokines in the course of experimental autoimmune anterior uveitis (EAAU) and elucidate the possible immunopathogenesis. Materials and methods Uveitis was induced in Lewis rats with bovine melanin-associated antigen. The clinical scoring of the inflammatory activity of the anterior chamber and leukocyte quantification in aqueous humor was done. RNA extraction from iris/ciliary body, and popliteal lymph nodes was performed to reveal the dynamic changes of 8 target miRNAs (miR-155-5p, miR-1

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20

Lin, Jim, and 林峯安. "Expressions of Lymphotactin and Its Receptor, XCR, in Lewis Rats with Experimental Autoimmune Anterior Uveitis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/42160491669821960335.

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碩士<br>臺中健康暨管理學院<br>生物科技學系碩士班<br>94<br>Acute anterior uveitis (AAU) is the most common form of uveitis in humans and the exact mechanism of AAU has yet to be determined. We have successfully created an animal model of Experimental Autoimmune Anterior Uveitis (EAAU) in Lewis rat. In this experiment, we studied the expression of lymphotactin – a chemokine which attracts lymphocytes to inflammation sites in the EAAU. We observed that the leukocytes of aqueous humor increased with the severity of inflammation of iris/ciliary body. There were specific lymphotactin and its receptor messenger RNA expr

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21

Lo, Sheng Min, and 羅聖旻. "The TLR Signaling of Retinal Pigment Epithelial Cells Contributed to the Development of Experimental Autoimmune Uveitis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/2ernm3.

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22

i-mo, fang, and 方怡謨. "Expression of Chemokines, Their Receptors and Effect of NF-kB Inhibitor, Pyrrolidine Dithiocarbamate, on Experimental Autoimmune Anterior Uveitis." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/81499843460851245233.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>90<br>Uveitis is a major cause of visual impairment. The most frequent form of human uveitis is acute anterior uveitis (AAU) of unknown etiology which accounts for approximately 75% of all uveitis. The exact mechanism of AAU has yet to be determined, although autoimmune origin was thought to be the causes. AAU is a highly recurrent disease. With the frequency of recurrent and disease progression, it may result in secondary complications such as cataract, cystoid macular edema or glaucoma. Steroids remain the mainstay of therapy for uveitis. However, some, particular

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23

Klímová, Aneta. "Mechanismy patogeneze experimentální autoimunitní uveitidy a možnosti jejich ovlivnění." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-265174.

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Introduction:Uveitis in an ocular inflammation affecting mostly people of working age. Uveitis is responsible for severe visual impairment despite of expanding new therapeutics. The animal models of uveitis were established, because the wide clinical variability of uveitis limits the studies in human medicine. The goal our project was to establish a reproducible model of experimental autoimmune uveitis in Czech Republic, and further on this model to observe the frequency of CD3+ and F4/80+ cells in retina, to assess the influence of microbial environment on intensity of intraocular inflammatio

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24

Seidler, Štangová Petra. "Studium imunopatologických mechanismů autoimunitní uveitidy a definování nových terapeutických možností." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-415776.

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The aim of this work was to gain new knowledge about mechanisms of autoimmune uveitis and to test new therapeutic possibilities that have not yet been studied in uveitis or whose effect is questionable. The main emphasis was placed on the role of microorganisms in the process of uveitis. A mouse model of experimental autoimmune uveitis including a germ-free model was used to achieve the aims and samples of patients' intraocular fluids were analyzed. In the experimental model, the intensity of inflammation was evaluated in vivo clinically and post mortem histologically. The effect of immunomodu

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25

Šlemín, Johan. "Vliv střevní mikrobioty na slizniční a systémovou imunitu při experimentální autoimunitní uveitidě." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-447086.

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The use of probiotics has emerged in the last decades as a promising strategy when it comes to the treatment of inflammatory diseases. Through modulation of composition of the intestinal microbiota and the signalling it provides, probiotics can favourably tune the immune system. Beneficial effects of probiotic treatment have been documented in multiple animal inflammatory disease models. The effect of probiotic treatment on uveitis-a sight- threatening disease-has however not yet been described. In our study, we have tested two commercially available probiotics-Escherichia coli Nissle 1917 (Ec

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