Academic literature on the topic 'Auxiliary channels'

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Journal articles on the topic "Auxiliary channels"

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Dvorak, Nolan M., Paul A. Wadsworth, Pingyuan Wang, Jia Zhou, and Fernanda Laezza. "Development of Allosteric Modulators of Voltage-Gated Na+ Channels: A Novel Approach for an Old Target." Current Topics in Medicinal Chemistry 21, no. 10 (2021): 841–48. http://dx.doi.org/10.2174/1568026621666210525105359.

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Given their primacy in governing the action potential (AP) of excitable cells, voltage-gated Na+ (Nav) channels are important pharmacological targets of therapeutics for a diverse array of clinical indications. Despite historically being a traditional drug target, therapeutics targeting Nav channels lack isoform selectivity, giving rise to off-target side effects. To develop isoform-selective modulators of Nav channels with improved target-specificity, the identification and pharmacological targeting of allosteric sites that display structural divergence among Nav channel isoforms represents a
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Flockerzi, Veit, and Bernd Fakler. "TR(i)P Goes On: Auxiliary TRP Channel Subunits?" Circulation Research 134, no. 4 (2024): 346–50. http://dx.doi.org/10.1161/circresaha.123.323178.

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Transient receptor potential (TRP) cation channels are a diverse family of channels whose members play prominent roles as cellular sensors and effectors. The important role of TRP channels (and mechanosensitive piezo channels) in the complex interaction of our senses with the environment was underlined by the award of the Nobel Prize in Physiology or Medicine to 2 pioneers in this field, David Julius and Ardem Patapoutian. There are many competent and comprehensive reviews on many aspects of the TRP channels, and there is no intention to expand on them. Rather, after an introduction to the nom
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Hoshi, Toshinori, Rong Xu, Shangwei Hou, Stefan H. Heinemann, and Yutao Tian. "A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid." Journal of General Physiology 142, no. 5 (2013): 507–22. http://dx.doi.org/10.1085/jgp.201311061.

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Long-chain polyunsaturated omega-3 fatty acids such as docosahexaenoic acid (DHA) at nanomolar concentrations reversibly activate human large-conductance Ca2+- and voltage-gated K+ (Slo1 BK) channels containing auxiliary β1 or β4 subunits in cell-free patches. Here we examined the action of DHA on the Slo1 channel without any auxiliary subunit and sought to elucidate the biophysical mechanism and the molecular determinants of the DHA sensitivity. Measurements of ionic currents through human Slo1 (hSlo1) channels reveal that the stimulatory effect of DHA does not require activation of the volta
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Zhou, Zijing, Xiaonuo Ma, Yiechang Lin, et al. "MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels." Science 381, no. 6659 (2023): 799–804. http://dx.doi.org/10.1126/science.adh8190.

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Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel–binding proteins have emerged. In this work, we found that MyoD (myoblast determination)–family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2 interacting partners. These transcriptional regulators bind to PIEZO1/2 channels, regulating channel inactivation. Using single-particle cryogenic electron microscopy, we mapped the interaction site in MDFIC to a lipidated, C-terminal helix that
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Jones, Lisa P., Shao-kui Wei та David T. Yue. "Mechanism of Auxiliary Subunit Modulation of Neuronal α1E Calcium Channels". Journal of General Physiology 112, № 2 (1998): 125–43. http://dx.doi.org/10.1085/jgp.112.2.125.

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Voltage-gated calcium channels are composed of a main pore-forming α1 moiety, and one or more auxiliary subunits (β, α2δ) that modulate channel properties. Because modulatory properties may vary greatly with different channels, expression systems, and protocols, it is advantageous to study subunit regulation with a uniform experimental strategy. Here, in HEK 293 cells, we examine the expression and activation gating of α1E calcium channels in combination with a β (β1–β4) and/or the α2δ subunit, exploiting both ionic- and gating-current measurements. Furthermore, to explore whether more than on
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Jiao, Yunjing, Qijing Lin, Kun Yao, et al. "Design of High-Precision Parallel AWG Demodulation System." Micromachines 14, no. 9 (2023): 1662. http://dx.doi.org/10.3390/mi14091662.

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Here, we present a high-precision demodulation method that supports the arrayed waveguide grating (AWG) system, which includes a 1 × 8 AWG as the primary filter with a 0.5 nm channel spacing and a 1 × 4 AWG as the auxiliary filter with a 1 nm channel spacing. The high precision is achieved through an innovative method of decoupling three channels, involving two adjacent channels of the primary filter and one channel of the secondary auxiliary filter. Simulation results show that the AWGs have a good transmission spectrum with crosstalk below −24.8 dB, non-uniformities below 0.8 dB, insertion l
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Dvorak, Nolan M., Cynthia M. Tapia, Aditya K. Singh, et al. "Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation." International Journal of Molecular Sciences 22, no. 24 (2021): 13541. http://dx.doi.org/10.3390/ijms222413541.

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Voltage-gated Na+ (Nav) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Nav channel α subunit that have been described (Nav1.1-Nav1.9), Nav1.1, Nav1.2, and Nav1.6 are the primary isoforms expressed in the central nervous system (CNS). Crucially, these three CNS Nav channel isoforms display differential expression across neuronal cell types and diverge with respect to their subcellular distributions. Considering these differences in terms of their localization, the CNS Nav channel isoforms could represent promising targets for the developme
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Sinha, Ashish, Haodong Gu, Namwoon Kim, and Renu Emile. "Signaling effects and the role of culture: movies in international auxiliary channels." European Journal of Marketing 53, no. 10 (2019): 2146–72. http://dx.doi.org/10.1108/ejm-09-2017-0587.

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Purpose Given the high uncertainty in the quality perception of experiential products, manufacturers use signals to influence consumers’ decisions. In the movie industry, literature shows that performance of the main channel (e.g. cinema) strongly influences the performance of auxiliary channels (e.g. DVDs). The success of a movie in the home country is also to be resonated by its good performance in host countries. However, the cultural contingency of these success-breeds-success (SBS) effects has not been examined. This paper aims to test the influence of cultural values on the SBS effects a
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Brown, Austin L., Zhiwen Liao, and Miriam B. Goodman. "MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity." Journal of General Physiology 131, no. 6 (2008): 605–16. http://dx.doi.org/10.1085/jgp.200709910.

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The ion channel formed by the homologous proteins MEC-4 and MEC-10 forms the core of a sensory mechanotransduction channel in Caenorhabditis elegans. Although the products of other mec genes are key players in the biophysics of transduction, the mechanism by which they contribute to the properties of the channel is unknown. Here, we investigate the role of two auxiliary channel subunits, MEC-2 (stomatin-like) and MEC-6 (paraoxonase-like), by coexpressing them with constitutively active MEC-4/MEC-10 heteromeric channels in Xenopus oocytes. This work extends prior work demonstrating that MEC-2 a
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Williams, Brittany, Josue A. Lopez, J. Wesley Maddox, and Amy Lee. "Functional impact of a congenital stationary night blindness type 2 mutation depends on subunit composition of Cav1.4 Ca2+ channels." Journal of Biological Chemistry 295, no. 50 (2020): 17215–26. http://dx.doi.org/10.1074/jbc.ra120.014138.

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Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human
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Dissertations / Theses on the topic "Auxiliary channels"

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Yasuda, Takahiro. "Modulation of calcium channel function and toxin sensitivity by auxiliary subunits /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18052.pdf.

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Molinarolo, Steven. "Biochemical techniques for the study of voltage-gated sodium channel auxiliary subunits." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6217.

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Voltage-gated sodium channels auxiliary subunits evolutionary emerged nearly 500 million years ago during the Cambrian explosion. These subunits alter one the most important ion channels to electrical signaling, the voltage-gated sodium channels support the propagation of electric impulses in animals. The mechanism for the auxiliary subunits effects on the channels is poorly understand, as is the stoichiometry between the auxiliary subunit and the channel. The focus of my thesis is to generate assays and to use these approaches to understand the interactions different types of voltage-gated ch
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Robinson, Philip. "Targeting of voltage-gated calcium channels to lipid rafts : the role of auxiliary alpha2/delta-1 subunits." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/targeting-of-voltagegated-calcium-channels-to-lipid-rafts-the-role-of-auxiliary-alpha2delta1-subunits(db84049c-1445-4486-9e31-34fa4110daf6).html.

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Ca2+ entry through voltage-gated calcium channels (CaVs) triggers a range of physiological events, including synaptic neurotransmission and muscular excito-contraction coupling. CaVs are often localised to discrete membrane microdomains and are required to be targeted to such fine structures in order to perform their cellular functions. CaVs are multi-subunit protein complexes that consist of a core, pore-forming α1 subunit and auxiliary β and α2/δ subunits. The α2/δ subunit is required for the optimal cell surface expression and function of CaVs and is itself localised to cholesterol-rich mem
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Zhao, Juan. "Biophysical characterization of neuronal and skeletal muscle sodium channels, and their regulation by auxiliary beta subunits." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28793/28793.pdf.

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Les canaux Na dépendants du voltage sont responsables de la phase ascendante des potentiels d’action. Ils sont formés d’une sous-unité principale  et d’une ou plusieurs sous-unités secondaire . La sous-unité  seule est suffisante pour former un canal fonctionnel cependant, les sous-unités  modulent la location, l’expression ainsi que les propriétés fonctionnelles de la sous-unité . Ma thèse ce concentre sur 3 canaux Na neuronaux (Nav1.6, Nav1.7 et Nav1.8) ainsi qu’un canal sodique du muscle squelettique (Nav1.4). Les canaux Na neuronaux sont importants pour la propagation de l’influx élec
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Saponaro, A. C. "THE AUXILIARY SUBUNIT TRIP8B ANTAGONIZES THE BINDING OF CAMP TO HCN2 CHANNELS THROUGH AN ALLOSTERIC MECHANISM." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229903.

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In neurons, hyperpolarization-activated cyclic nucleotide-regulated (HCN1-4) channels are the molecular determinants of the Ih current, which controls several cognitive processes. Unique among the voltage-gated ion channel superfamily, HCN channels are modulated by the direct binding of cAMP to their cytoplasmic cyclic nucleotide binding domain (CNBD). Thus, cyclic nucleotide-dependent conformational changes of CNBD are determinant in the regulation of HCN channel opening. The rearrangements induced by cAMP in HCN CNBD are not yet elucidated, since for this protein is known only the cAMP-bound
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Zhou, Wei. "Structural and functional studies on the regulation of K+ channels by local anesthetics and intracellular auxiliary subunits /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3142460.

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Soubrane, Camille Hélène. "Identification of CACHD1 as a novel [alpha]2[delta]-like auxiliary subunit of Cav3 voltage-gated calcium channels." Thesis, University of Reading, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658003.

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The putative CACHD1 gene was identified following a systematic search for ligand-binding proteins as novel drug targets. The CACHD1 gene encodes CACHD1 and has a predicted protein structure similar to that of the [alpha]2[delta] family of voltage-gated Ca2+ channel (VGCC) auxiliary subunits, which modulates the biophysical properties and plasma membrane expression of VGCCs. On this basis, the hypothesis that CACHD1 represents a novel [alpha]2[delta]-like VGCC auxiliary subunit was tested.
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Terhag, Jan [Verfasser], Michael [Gutachter] Hollmann, and Guiscard Friedrich Aldous [Gutachter] Seebohm. "Auxiliary subunits of voltage-gated Calcium channels as modulators of ionotropic glutamate receptors / Jan Terhag ; Gutachter: Michael Hollmann, Guiscard Friedrich Aldous Seebohm." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/111670952X/34.

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Despang, Patrick Sebastian [Verfasser], Dirk [Akademischer Betreuer] Isbrandt та Markus [Akademischer Betreuer] Plomann. "Autism-related mutations of auxiliary Cavβ-subunits : electrophysiological characterization of effects on the function of voltage-gated calcium channels / Patrick Sebastian Despang ; Akademische Betreuer: Dirk Isbrandt, Markus Plomann". Köln : Deutsche Zentralbibliothek für Medizin, 2020. http://d-nb.info/1215226047/34.

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Stephani, Friederike Lene Brigitte [Verfasser]. "α2δ3 is the preferred auxiliary α2δ subunit of Cav2.1 channels in spiral ganglion neurons and is required for development of auditory nerve fiber synapses / Friederike Lene Brigitte Stephani". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1216877823/34.

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Book chapters on the topic "Auxiliary channels"

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Borowik, Sergej, and Henry M. Colecraft. "Voltage-Gated Calcium Channel Auxiliary β Subunits." In Voltage-Gated Calcium Channels. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08881-0_4.

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Obermair, Gerald J., and Bernhard E. Flucher. "Neuronal Functions of Auxiliary Calcium Channel Subunits." In Modulation of Presynaptic Calcium Channels. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6334-0_2.

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Matthes, Jan, and Stefan Herzig. "Auxiliary β-Subunits of L-Type Ca2+ Channels in Heart Failure." In Pathologies of Calcium Channels. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40282-1_14.

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Dolphin, Annette C., and Gerald J. Obermair. "Regulation of Calcium Channels and Synaptic Function by Auxiliary α2δ Subunits." In Voltage-Gated Calcium Channels. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08881-0_5.

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Molinarolo, Steven, Daniele Granata, Vincenzo Carnevale, and Christopher A. Ahern. "Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits." In Voltage-gated Sodium Channels: Structure, Function and Channelopathies. Springer International Publishing, 2017. http://dx.doi.org/10.1007/164_2017_75.

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Weik, Martin H. "auxiliary channel." In Computer Science and Communications Dictionary. Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_1173.

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Ramachandran, Nitya, and P. Yogesh. "Modified Auxiliary Channel Diffie Hellman Encrypted Key Exchange Authentication Protocol." In Information Technology and Mobile Communication. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20573-6_74.

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Pietrobon, D. "Introduction." In Guidebook to Protein Toxins and Their Use in Cell Biology. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599555.003.0058.

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Abstract Voltage-gated Ca2+ channels are multisubunit complexes composed of a channel-forming and voltage-sensing a1 subunit and several regulatory and/or auxiliary subunits. They constitute a complex family of channels comprising a large number of different subtypes, which have in common a steep voltage dependence of open probability and a very high selectivity for Ca2+over Na+ and K+ ions in physiological solutions.
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Levitan, Irwin B., and Leonard K. Kaczmarek. "Diversity in the Structure and Function of Ion Channels." In The Neuron. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199773893.003.0007.

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Voltage clamp and patch clamp techniques are used to reveal heterogeneity of ion currents carried through voltage-dependent sodium, calcium, and potassium channels. Advances in channel molecular biology have made it clear that the diversity of ion channels is even greater than was suspected from these electrophysiological measurements. This diversity is achieved by several different mechanisms, including the existence of multiple genes for the pore-forming α‎ subunits of ion channels, alternative splicing of the messenger RNA transcribed from each individual gene, formation of heterotetramers
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Leidenheimer, N. J., J. E. Dildy-Mayfield, and R. A. Harris. "Effect of Ethanol on Voltage-Gated Ion Channels." In The Pharmacology of Alcohol and Alcohol Dependence. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195100945.003.0010.

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Abstract In this chapter we review the actions of ethanol on voltage-activated calcium, sodium, and potassium channels, as well as on calcium-activated potassium channels. These channels are critical for the control of neuronal excitability and are responsible for the propagation of nerve impulses and the regulation of neurotransmitter release. Because of their importance, these channels have been examined in detail with diverse techniques. Molecular biological approaches have helped elucidate their protein structure and have provided evidence for their heterogeneity and genetic diversity. Vol
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Conference papers on the topic "Auxiliary channels"

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Jiang, Ze-Kun, Li Wang, Chang-Shun Wang, Alexander S. Solntsev, and Xian-Min Jin. "Protection of optical channels and non-classical sources using dynamic modulation." In CLEO: Applications and Technology. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_at.2024.jth2a.220.

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A method for protecting optical channels and non-classical sources in integrated photonic systems using dynamic modulation is proposed, which provides higher design freedom and scalability than topological protection with the need for auxiliary waveguides.
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Jabir, M. V., N. Fajar R. Annafianto, I. A. Burenkov, A. Battou, and S. V. Polyakov. "Untraceable In-situ Channel Monitoring via Quantum Measurement." In CLEO: Applications and Technology. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_at.2024.jw2a.158.

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We demonstrate an in-situ scheme for monitoring conditions of a classical communications channel via regular data transmission, and with no auxiliary communication. Employing quantum state discrimination confidence, we experimentally observe amplitude and phase noise detection.
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Xing, Sixuan, Jianhong Xiang, Ying Wang, Liangang Qi, and Yu Zhong. "An Encoded Double Auxiliary Pilot Channel Estimation Method for Intrinsic Interference Cancellation in FBMC/OQAM Systems." In 2024 IEEE International Conference on Artificial Intelligence in Engineering and Technology (IICAIET). IEEE, 2024. http://dx.doi.org/10.1109/iicaiet62352.2024.10730122.

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Xue, Henfeng, Yang Zou, Zipeng Liang, et al. "Demonstration of High-Sensitivity Auxiliary Management and Control Channel Detection Based on Native 50G PON Modules." In 2024 Asia Communications and Photonics Conference (ACP) and International Conference on Information Photonics and Optical Communications (IPOC). IEEE, 2024. https://doi.org/10.1109/acp/ipoc63121.2024.10809442.

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Lu, Ji, and Minjun Wu. "Research on Speech Enhancement of Vocal Music Auxiliary Teaching System Based on Time-Frequency Fusion and Multi-Channel Attention Mechanism." In 2024 8th Asian Conference on Artificial Intelligence Technology (ACAIT). IEEE, 2024. https://doi.org/10.1109/acait63902.2024.11022295.

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Fertonani, D., and T. M. Duman. "Upper Bounding the Deletion Channel Capacity by Auxiliary Memoryless Channels." In ICC 2009 - 2009 IEEE International Conference on Communications. IEEE, 2009. http://dx.doi.org/10.1109/icc.2009.5199553.

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Wu, Yiting, Chuansheng Yang, Chao Wang, Hongming Chen, and Qihong Ye. "Low-light image enhancement combining dehazing and auxiliary channels." In 3rd International Conference on Advanced Algorithms and Signal Image Processing (AASIP 2023), edited by Kannimuthu Subramaniam and Pavel Loskot. SPIE, 2023. http://dx.doi.org/10.1117/12.3005867.

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Wang, Shengde, Zhenqiang Yao, Hong Shen, and Guohu Luo. "Numerical Analysis on the Hydraulic Performance of the Auxiliary Impeller in Large Capacity Canned-Motor Pump." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-87285.

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A special structure named auxiliary impeller is designed in the large capacity canned-motor pump to improve the performance of inner loop cooling system. The structure is set on the rotor shaft using the center hole as the inlet conduit and four holes perpendicular to the center hole as the blade channels. The auxiliary impeller is driven by the rotor shaft of the motor and functions as a centrifugal pump. The inner coolant circulates in the clearance of the pump under the effect of centrifugal force generated by the impeller. In this paper, the output pressure of the auxiliary impeller at dif
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Li, Wenming, Fanghao Yang, Tamanna Alam, Benli Peng, Xiaopeng Qu, and Chen Li. "Enhanced Flow Boiling in Microchannels Using Auxiliary Channels and Multiple Micronozzles." In ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/mnhmt2016-6712.

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Flow boiling in an array of five parallel microchannels (W=200 μm, H=250 μm, L=10 mm) can be dramatically enhanced using self-excited and self-sustained high frequency two-phase oscillations induced by two-nozzle configuration. However, the effect of the two-phase oscillations is confined to the downstream of the microchannels. In this study, four-nozzle microchannel configuration is developed with an aim to extend mixing to the entire channel. Flow boiling in the four-nozzle microchannel is experimentally studied with deionized water over a mass flux range of 120 to 600 kg/m2 s. Overall avera
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Phung, Cao Vien, Anna Engelmann, Thomas Kuerner, and Admela Jukan. "Improving THz Quality-of-Transmission with Systematic RLNC and Auxiliary Channels." In 2020 IEEE International Conference on Communications Workshops (ICC Workshops). IEEE, 2020. http://dx.doi.org/10.1109/iccworkshops49005.2020.9145148.

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Reports on the topic "Auxiliary channels"

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Little, Charles, and David Biedenharn. Technical assessment of the Old, Mississippi, Atchafalaya, and Red (OMAR) Rivers : channel geometry analysis. Engineer Research and Development Center (U.S.), 2022. http://dx.doi.org/10.21079/11681/45147.

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The Old River Control Complex (ORCC) consists of the Low Sill, Auxiliary, and Overbank structures as features of the Old River Control Structure (ORCS) and the privately owned hydro-electric power plant. Operations of the ORCC manage the hydrologic connectivity between the Mississippi River and the Atchafalaya River/Red River systems. The morphology of the Old, the Mississippi, the Atchafalaya, and the Red Rivers (OMAR) has been influenced by the flow distribution at the ORCC, as well as the accompanying bed sediments. A geomorphic assessment of the OMAR is underway to understand the morpholog
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Pokryshen, Dmytro A., Evgeniy H. Prokofiev, and Albert A. Azaryan. Blogger and YouTube services at a distant course “Database management system Microsoft Access”. [б. в.], 2019. http://dx.doi.org/10.31812/123456789/3272.

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The article is devoted to the coverage of the course “Database management system Microsoft Access”, an educational blog review “The development of a creative child. ІCТ”, which is used as an auxiliary tool for promoting a course and teacher in the Internet, structural analysis of this blog is made. The channel location is set on YouTube video hosting and how it is used in the course on databases. Attention is drawn to the fact that theoretical and practical material is considered on real, implemented informational and analytical systems. To prepare students for the Olympiads and provide method
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